LiteFold/InterPro · Datasets at Hugging Face

IPR019482

19,482

Interleukin-12 beta, central domain

IL-12_beta_cen-dom

Domain

1,397

false

This entry represents the central domain (domain 2) of the beta subunit (also known as subunit p40) interleukin-12 (IL-12). This domain is largely β-stranded with a fibronectin III-like structure. IL-12 is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with IL-12 sub...

[]

0

[ "PFAM" ]

[ "PF10420" ]

[ "IL12p40_C" ]

[ 1397 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6783783", "R-HSA-6785807", "R-HSA-9020591", "R-HSA-9020933", "R-MMU-9020591", "R-MMU-9020933", "R-SSC-9020591", "R-SSC-9020933" ]

[ "REACTOME:R-HSA-6783783", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-9020591", "REACTOME:R-HSA-9020933", "REACTOME:R-MMU-9020591", "REACTOME:R-MMU-9020933", "REACTOME:R-SSC-9020591", "REACTOME:R-SSC-9020933" ]

8

[ "1f42", "1f45", "3d85", "3d87", "3duh", "3hmx", "3qwr", "4grw", "5mj3", "5mj4", "5mxa", "5mzv", "5njd", "6sff", "6smc", "6sp3", "6uib", "6wdq", "7pur", "7r3n", "8cr5", "8cr6", "8cr8", "8odz", "8oe0", "8oe4", "8pb1", "8uui", "8xrp", "8yi7" ]

30

[ "PUB00024781", "PUB00044316" ]

[ "10899108", "15661020" ]

[ "Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.", "Defects in the interferon-gamma and interleukin-12 pathways." ]

[ 2000, 2005 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 1397 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 18, 11, 2, 4 ]

4

true

Domain

Interleukin-12 beta, central domain

IL-12_beta_cen-dom

6

IPR019485

19,485

V(D)J recombination-activating protein 1, Zinc finger

RAG1_Znf

Domain

14,030

false

The development of B and T cells depends on the rearrangement of variable (V), diversity (D), and joining (J) gene segments to produce mature Ig and T cell receptor coding regions. This rearrangement process, known as V(D)J recombination is initiated by the complex, multi-domain proteins RAG1 and RAG2. The RAG proteins...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF10426", "PS51765" ]

[ "zf-RAG1", "ZF_RAG1" ]

[ 13137, 13914 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "1rmd", "3jbw", "3jbx", "3jby", "6cg0", "6cij", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq", "6oer", "6oes", "6oet", "6v0v", "6xnx", "6xny", "6xnz", "9jpu", "9jpx", "9jqn"...

34

[ "PUB00030727", "PUB00077748", "PUB00077749" ]

[ "9228952", "14671314", "22796426" ]

[ "Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.", "Autoubiquitylation of the V(D)J recombinase protein RAG1.", "Characterization of RAG1 and IgM (mu chain) marking development of the immune system in red-spotted grouper (Epinephel...

[ 1997, 2003, 2012 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 14030 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 3, 3 ]

4

true

Domain

V(D)J recombination-activating protein 1, Zinc finger

RAG1_Znf

8

IPR019486

19,486

Argonaute hook domain

Argonaute_hook_dom

Domain

4,483

false

This entry represents a region called the argonaute hook [ ]. It has been shown to bind to the Piwi domain ( ) of argnonaute proteins.

[]

0

[ "PFAM" ]

[ "PF10427" ]

[ "Ago_hook" ]

[ 4483 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-426496", "R-DME-5578749", "R-HSA-1912408", "R-HSA-2559580", "R-HSA-2559585", "R-HSA-4086398", "R-HSA-426496", "R-HSA-5578749", "R-HSA-5628897", "R-HSA-5687128", "R-HSA-8853884", "R-HSA-8934593", "R-HSA-8936459", "R-HSA-8943723", "R-HSA-8948700", "R-HSA-8986944", "R-HSA-9018519...

[ "REACTOME:R-DME-426496", "REACTOME:R-DME-5578749", "REACTOME:R-HSA-1912408", "REACTOME:R-HSA-2559580", "REACTOME:R-HSA-2559585", "REACTOME:R-HSA-4086398", "REACTOME:R-HSA-426496", "REACTOME:R-HSA-5578749", "REACTOME:R-HSA-5628897", "REACTOME:R-HSA-5687128", "REACTOME:R-HSA-8853884", "REACTOME:...

27

[]

0

[ "PUB00044140" ]

[ "17891150" ]

[ "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain." ]

[ 2007 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 4483 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 1, 9, 11, 19 ]

5

true

Domain

Argonaute hook domain

Argonaute_hook_dom

4

IPR019487

19,487

RAM signalling pathway, SOG2

RAM_signalling_pathway_SOG2

Family

1,793

false

The RAM signalling pathway regulates Ace2p transcription factor activity and cellular morphogenesis in Saccharomyces cerevisiae (Baker's yeast), and is thought to be conserved amongst eukaryotes [ ].

[]

0

[ "PFAM" ]

[ "PF10428" ]

[ "SOG2" ]

[ 1793 ]

1

[ "REACTOME" ]

[ "R-SPO-983168" ]

[ "REACTOME:R-SPO-983168" ]

1

[]

0

[ "PUB00044493" ]

[ "12972564" ]

[ "RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1793 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Family

RAM signalling pathway, SOG2

RAM_signalling_pathway_SOG2

4

IPR019488

19,488

Nuclear pore RNA shuttling protein Mtr2

Nucl_pore_RNA_shuttling_Mtr2

Family

256

false

Mtr2 is a monomeric, dual-action, RNA-shuttle protein found in yeasts. Transport across the nuclear-cytoplasmic membrane is via the macro-molecular membrane-spanning nuclear pore complex, NPC. The pore is lined by a subset of NPC members called nucleoporins that present FG (Phe-Gly) receptors, characteristically GLFG a...

[]

0

[ "PFAM" ]

[ "PF10429" ]

[ "Mtr2" ]

[ 256 ]

1

[ "REACTOME" ]

[ "R-SCE-159236" ]

[ "REACTOME:R-SCE-159236" ]

1

[ "1of5", "1q40", "1q42", "4wwu", "8hbn", "8hfr" ]

6

[ "PUB00030110" ]

[ "14504280" ]

[ "The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export." ]

[ 2003 ]

1

[]

0

null

[ "Dikarya" ]

[ 256 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Nuclear pore RNA shuttling protein Mtr2

Nucl_pore_RNA_shuttling_Mtr2

2

IPR019489

19,489

Clp ATPase, C-terminal

Clp_ATPase_C

Domain

126,664

false

Most Clp ATPases form complexes with peptidase subunits and are involved in protein degradation, though some, such as ClpB, do not associate with peptidases and are involved in protein disaggregation [ ]. This entry represents the C-terminal domain of Clp ATPases, often referred to as the D2-small domain, which forms a...

[]

0

[ "PFAM", "SMART" ]

[ "PF10431", "SM01086" ]

[ "ClpB_D2-small", "ClpB_D2-small" ]

[ 114905, 125649 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9837999", "R-MMU-9837999", "R-RNO-9837999" ]

[ "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-9837999", "REACTOME:R-RNO-9837999" ]

3

[ "1do0", "1do2", "1e94", "1g3i", "1g41", "1g4a", "1g4b", "1hqy", "1ht1", "1ht2", "1im2", "1ksf", "1kyi", "1ofh", "1ofi", "1qvr", "1r6b", "1um8", "1yyf", "3hte", "3hws", "3j3r", "3j3s", "3j3t", "3j3u", "3pxi", "4ciu", "4d2q", "4d2u", "4d2x", "4fct", "4fcv"...

164

[ "PUB00030406", "PUB00045432" ]

[ "14567920", "16879409" ]

[ "The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state.", "A camel passes through the eye of a needle: protein unfolding activity of Clp ATPases." ]

[ 2003, 2006 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 55, 104883, 19854, 67, 1805 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 46, 3, 5, 3, 4, 5, 9, 4, 43, 16, 3, 2, 101 ]

13

true

Domain

Clp ATPase, C-terminal

Clp_ATPase_C

9

IPR019491

19,491

Lipoate protein ligase, C-terminal

Lipoate_protein_ligase_C

Domain

7,738

false

This is the C-terminal domain of a bacterial lipoate protein ligase [ ]. There is no conservation between this C terminus and that of vertebrate lipoate protein ligase C-termini, but both are associated with , further upstream. This C-terminal domain is more stable than and the hypothesis is that the C-terminal domain ...

[]

0

[ "PFAM" ]

[ "PF10437" ]

[ "Lip_prot_lig_C" ]

[ 7738 ]

1

[ "EC", "REACTOME" ]

[ "6.3.1.20", "R-PFA-9857492" ]

[ "EC:6.3.1.20", "REACTOME:R-PFA-9857492" ]

2

[ "1vqz", "1x2g", "1x2h", "3a7a", "3a7r", "3r07", "4tvw", "4tvy", "5iby", "5ich", "5icl", "5idh", "5ij6", "5t8u", "6jom", "8cri", "8crj", "8crl" ]

18

[ "PUB00038224" ]

[ "16043486" ]

[ "Crystal structure of lipoate-protein ligase A from Escherichia coli. Determination of the lipoic acid-binding site." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Edafosvirus sp.", "Eukaryota", "unclassified sequences" ]

[ 131, 7211, 1, 345, 50 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Lipoate protein ligase, C-terminal

Lipoate_protein_ligase_C

9

IPR019492

19,492

Cyclo-malto-dextrinase, C-terminal

Cyclo-malto-dextrinase_C

Domain

2,201

false

This domain is at the very C terminus of cyclo-malto-dextrinase proteins and consists of 8 β strands, is largely globular and appears to help stabilise the active sites created by upstream domains, , and . Cyclo-malto-dextrinases hydrolyse cyclodextrans to maltose and glucose and catalyse trans-glycosylation of oligosa...

[]

0

[ "PFAM" ]

[ "PF10438" ]

[ "Cyc-maltodext_C" ]

[ 2201 ]

1

[]

0

[ "1h3g", "3edd", "3ede", "3edf", "3edj", "3edk", "9fyz" ]

7

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2158, 10, 33 ]

3

[]

0

true

Domain

Cyclo-malto-dextrinase, C-terminal

Cyclo-malto-dextrinase_C

3

IPR019493

19,493

Bacteriocin, class IIb, lactacin-related

Bacteriocin_IIb_lactacin-rel

Family

723

false

Bacteriocins are proteinaceous toxins produced by bacteria to inhibit the growth of similar or closely related strains. The producer bacteria are protected from the effects of their own bacteriocins by production of a specific immunity protein which is co-transcribed with the genes encoding the bacteriocins, e.g. . The...

[ "GO:0042742" ]

[ "defense response to bacterium" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF10439" ]

[ "Bacteriocin_IIc" ]

[ 723 ]

1

[]

0

[]

0

[ "PUB00044165", "PUB00044166" ]

[ "17074857", "17298586" ]

[ "The blp bacteriocins of Streptococcus pneumoniae mediate intraspecies competition both in vitro and in vivo.", "Diversity of enterococcal bacteriocins and their grouping in a new classification scheme." ]

[ 2007, 2007 ]

2

[]

0

null

[ "Bacteria" ]

[ 723 ]

1

[]

0

true

Family

Bacteriocin, class IIb, lactacin-related

Bacteriocin_IIb_lactacin-rel

3

IPR019494

19,494

FIST, C-domain

FIST_C

Domain

10,022

false

This entry represents a novel sensory domain, designated FIST_C (short for F-box and intracellular signal transduction, C-terminal), which is present in signal transduction proteins from bacteria, archaea and eukaryotes. The chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino aci...

[]

0

[ "PFAM", "SMART" ]

[ "PF10442", "SM01204" ]

[ "FIST_C", "FIST_C" ]

[ 9629, 9714 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8951664", "R-HSA-983168", "R-MMU-8951664", "R-MMU-983168" ]

[ "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-8951664", "REACTOME:R-MMU-983168" ]

4

[ "8s7d", "8s7e", "8ua3", "8ua6" ]

4

[ "PUB00044261" ]

[ "17855421" ]

[ "FIST: a sensory domain for diverse signal transduction pathways in prokaryotes and ubiquitin signaling in eukaryotes." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 7762, 1923, 172, 165 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 1, 4, 2, 5 ]

5

true

Domain

FIST, C-domain

FIST_C

2

IPR019495

19,495

Exosome complex component CSL4, C-terminal

EXOSC1_C

Domain

4,152

false

Exosome is a complex of 3' --> 5' exoribonucleases that play a major role in diverse RNA processing and degradation pathways. The eukaryotic exosome complex contains 9 proteins. Six RNase PH domain containing proteins (Rrp41, Rrp42, Rrp43, Rrp45, Rrp46, and Mtr3) form a catalytic ring, three RNA binding domain containi...

[ "GO:0003723", "GO:0000178" ]

[ "RNA binding", "exosome (RNase complex)" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF10447" ]

[ "EXOSC1" ]

[ 4152 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-380994", "R-HSA-429958", "R-HSA-450385", "R-HSA-450513", "R-HSA-450604", "R-HSA-6791226", "R-HSA-9930044", "R-MMU-429958", "R-MMU-450385", "R-MMU-450513", "R-MMU-450604", "R-MMU-6791226", "R-MMU-9930044", "R-SCE-429958", "R-SCE-450385", "R-SCE-450513", "R-SCE-6791226", "R-SP...

[ "REACTOME:R-HSA-380994", "REACTOME:R-HSA-429958", "REACTOME:R-HSA-450385", "REACTOME:R-HSA-450513", "REACTOME:R-HSA-450604", "REACTOME:R-HSA-6791226", "REACTOME:R-HSA-9930044", "REACTOME:R-MMU-429958", "REACTOME:R-MMU-450385", "REACTOME:R-MMU-450513", "REACTOME:R-MMU-450604", "REACTOME:R-MMU-6...

19

[ "2ba1", "2nn6", "3m7n", "3m85", "4ifd", "4oo1", "5c0w", "5c0x", "5g06", "5jea", "5k36", "5okz", "5vzj", "6d6q", "6d6r", "6fsz", "6h25", "6lqs", "7ajt", "7aju", "7d4i", "8pel", "8qcf", "8r1o", "9g8m", "9g8n", "9g8o", "9g8p" ]

28

[ "PUB00035569", "PUB00045433", "PUB00045434" ]

[ "17174896", "10465791", "17173052" ]

[ "Reconstitution, activities, and structure of the eukaryotic RNA exosome.", "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.", "A single subunit, Dis3, is essentially responsible for yeast exosome core activity." ]

[ 2006, 1999, 2007 ]

3

[]

0

null

[ "Archaea", "Eukaryota", "metagenomes" ]

[ 67, 4083, 2 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 8, 1, 1, 5, 1, 1, 3, 2, 1, 1, 4 ]

11

true

Domain

Exosome complex component CSL4, C-terminal

EXOSC1_C

8

IPR019496

19,496

FMR1-interacting protein 1, conserved domain

NUFIP1_cons_dom

Domain

3,873

false

FMR1-interacting protein 1 (Nufip1) has been implicated in the assembly of the large subunit of the ribosome [ ] and in telomere maintenance [ ]. It is known to bind RNA [ ] and is phosphorylated upon DNA damage [ ]. This entry represents a conserved domain found within Nufip1. Some proteins containing this region also...

[]

0

[ "PFAM" ]

[ "PF10453" ]

[ "NUFIP1" ]

[ 3873 ]

1

[]

0

[ "2m3f", "4nut" ]

2

[ "PUB00044401", "PUB00044402", "PUB00044403", "PUB00044404" ]

[ "10567587", "16552446", "10556305", "17525332" ]

[ "Synthetic lethality with conditional dbp6 alleles identifies rsa1p, a nucleoplasmic protein involved in the assembly of 60S ribosomal subunits.", "Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.", "A novel RNA-binding nuclear protein th...

[ 1999, 2006, 1999, 2007 ]

4

[]

0

null

[ "Eukaryota" ]

[ 3873 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 3, 2, 3, 1, 1, 1, 4, 2, 1, 1, 6 ]

11

true

Domain

FMR1-interacting protein 1, conserved domain

NUFIP1_cons_dom

2

IPR019497

19,497

Sorting nexin protein, WASP-binding domain

Sorting_nexin_WASP-bd-dom

Domain

9,089

false

The C-terminal region of the Sorting nexin group of proteins appears to carry a BAR-like (Bin/amphiphysin/Rvs) domain. This domain is very diverse and the similarities with other BAR domains are few. In the Sorting nexins it is associated with , and in combination with PX appears to be necessary to bind WASP along with...

[]

0

[ "PFAM" ]

[ "PF10456" ]

[ "BAR_3_WASP_bdg" ]

[ 9089 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-432722", "R-CEL-8856828", "R-HSA-432722", "R-HSA-8856828", "R-MMU-432722", "R-MMU-8856828" ]

[ "REACTOME:R-CEL-432722", "REACTOME:R-CEL-8856828", "REACTOME:R-HSA-432722", "REACTOME:R-HSA-8856828", "REACTOME:R-MMU-432722", "REACTOME:R-MMU-8856828" ]

6

[ "2rai", "2raj", "2rak", "3dyt", "3dyu", "4akv" ]

6

[ "PUB00014978" ]

[ "14993925" ]

[ "The BAR-domain family of proteins: a case of bending and binding?" ]

[ 2004 ]

1

[]

[ "IPR037425", "IPR037427" ]

0

2

0

[ "Cohnella soli", "Eukaryota" ]

[ 1, 9088 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 10, 1, 17, 9, 12 ]

6

true

Domain

Sorting nexin protein, WASP-binding domain

Sorting_nexin_WASP-bd-dom

6

IPR019498

19,498

MENTAL domain

MENTAL

Domain

3,534

false

The following proteins share a conserved region called the MENTAL (MLN64 N-terminal) domain, composed of four transmembrane helices with three short intervening loops [ , , ]: Animal MLN64 (metastatic lymph node 64), a late endosomal membrane protein containing a carboxyl-terminal cholesterol binding START domain ( ). ...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF10457", "PS51439" ]

[ "MENTAL", "MENTAL" ]

[ 3528, 3165 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-196108", "R-HSA-196108", "R-MMU-196108" ]

[ "REACTOME:R-DRE-196108", "REACTOME:R-HSA-196108", "REACTOME:R-MMU-196108" ]

3

[]

0

[ "PUB00044355", "PUB00044356", "PUB00052616" ]

[ "12393907", "15718238", "16709157" ]

[ "MENTHO, a MLN64 homologue devoid of the START domain.", "Functional characterization of the MENTAL domain.", "MLN64 and MENTHO, two mediators of endosomal cholesterol transport." ]

[ 2002, 2005, 2006 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 3531 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 17, 7, 7 ]

6

true

Domain

MENTAL domain

MENTAL

8

IPR019500

19,500

Peptidase S46

Pep_S46

Family

5,678

false

Dipeptidyl aminopeptidase BII from Pseudoxanthomonas mexicana is a serine protease classified into clan PA, family S46. It is able to cleave a variety of dipeptides from the amino-terminus of substrate peptides [ ]. Another characterised member of the S46 family of dipeptidyl-peptidases from bacteria is dipeptidyl-pept...

[ "GO:0008239", "GO:0070009" ]

[ "dipeptidyl-peptidase activity", "serine-type aminopeptidase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PANTHER" ]

[ "PF10459", "PTHR38469" ]

[ "Peptidase_S46", "" ]

[ 5678, 5649 ]

2

[ "EC" ]

[ "3.4.14.-" ]

[ "EC:3.4.14.-" ]

1

[ "3woi", "3woj", "3wok", "3wol", "3wom", "3won", "3woo", "3wop", "3woq", "3wor", "4xzy", "4y01", "4y02", "4y04", "4y06", "5jwf", "5jwg", "5jwi", "5jxf", "5jxk", "5jxp", "5jy0", "5sdc", "5sdd", "5sde", "5sdf", "5sdg", "5sdh", "5sdi", "5sdj", "5sdk", "5sdl"...

47

[ "PUB00063575", "PUB00075339" ]

[ "11096098", "24637761" ]

[ "Porphyromonas gingivalis DPP-7 represents a novel type of dipeptidylpeptidase.", "Crystallization and preliminary X-ray crystallographic studies of dipeptidyl aminopeptidase BII from Pseudoxanthomonas mexicana WO24." ]

[ 2001, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Natronococcus amylolyticus DSM 10524", "metagenomes", "unclassified Caudoviricetes" ]

[ 5467, 60, 1, 147, 3 ]

5

[]

0

true

Family

Peptidase S46

Pep_S46

2

IPR019501

19,501

Peptidase M30, hyicolysin

Peptidase_M30_hyicolysin

Domain

255

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[]

0

[ "PFAM" ]

[ "PF10460" ]

[ "Peptidase_M30" ]

[ 255 ]

1

[]

0

[ "7bb8", "7bb9" ]

2

[ "PUB00003579", "PUB00063584" ]

[ "7674922", "8195076" ]

[ "Evolutionary families of metallopeptidases.", "Biochemical properties of a novel metalloprotease from Staphylococcus hyicus subsp. hyicus involved in extracellular lipase processing." ]

[ 1995, 1994 ]

2

[]

0

null

[ "Acidianus ambivalens", "Bacteria", "Ricinus communis", "hydrothermal vent metagenome" ]

[ 1, 252, 1, 1 ]

4

[]

0

true

Domain

Peptidase M30, hyicolysin

Peptidase_M30_hyicolysin

3

IPR019503

19,503

Peptidase M66 domain

Peptidase_M66_dom

Domain

581

false

The peptidase family M66 domain is a zinc metalloprotease found in: Enterohemorrhagic Escherichia coli (EHEC) neutral zinc metalloprotease StcE. Aeromonas hydrophila ToxR-regulated lipoprotein TagA. Vibrio cholerae ToxR-activated gene A lipoprotein TagA. The peptidase family M66 domain adopts a characteristic mixed α+β...

[ "GO:0004222" ]

[ "metalloendopeptidase activity" ]

[ "molecular_function" ]

1

[ "PROFILE" ]

[ "PS51694" ]

[ "PEPTIDASE_M66" ]

[ 581 ]

1

[ "EC", "METACYC" ]

[ "3.4.24.-", "PWY-8119" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119" ]

2

[ "3ujz" ]

1

[ "PUB00059544" ]

[ "22483117" ]

[ "Structural insight into the bacterial mucinase StcE essential to adhesion and immune evasion during enterohemorrhagic E. coli infection." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 535, 45, 1 ]

3

[]

0

true

Domain

Peptidase M66 domain

Peptidase_M66_dom

4

IPR019504

19,504

Peptidase U49, Lit peptidase

Peptidase_U49_Lit_pept

Family

601

false

This entry consists of peptidases belonging to MEROPS peptidase family U49 (Lit peptidase, clan U-). The peptidase families associated with clan U- have an unknown catalytic mechanism as the protein fold of the active site domain and the active site residues have not been reported. The Lit peptidase from Escherichia co...

[]

0

[ "PFAM" ]

[ "PF10463" ]

[ "Peptidase_U49" ]

[ 601 ]

1

[]

0

[]

0

[ "PUB00063593" ]

[ "15196039" ]

[ "Identification of essential residues within Lit, a cell death peptidase of Escherichia coli K-12." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Peduoviridae", "metagenomes" ]

[ 584, 3, 3, 2, 9 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Peptidase U49, Lit peptidase

Peptidase_U49_Lit_pept

8

IPR019505

19,505

Peptidase U40

Peptidase_U40

Family

37

false

Proteins in this entry include P5 murein endopeptidase from Pseudomonas phage phi6. P5 murein endopeptidase has lytic activity against several Gram-negative bacteria [ ]. It is thought that the enzyme cleaves the cell wall peptide bridge formed by meso-2,6-diaminopimelic acid and D-Alanine.

[]

0

[ "PFAM" ]

[ "PF10464" ]

[ "Peptidase_U40" ]

[ 37 ]

1

[]

0

[ "4dq5", "4dq7", "4dqj" ]

3

[ "PUB00088226" ]

[ "1390911" ]

[ "The lytic enzyme of the Pseudomonas phage phi 6. Purification and biochemical characterization." ]

[ 1992 ]

1

[]

0

null

[ "Orthocystovirus" ]

[ 37 ]

1

[]

0

true

Family

Peptidase U40

Peptidase_U40

1

IPR019507

19,507

Protease A inhibitor IA3

Pai3

Family

22

false

The IA3 polypeptide of Saccharomyces cerevisiae (also known as Pai3) is an 8kDa inhibitor of the vacuolar aspartic proteinase (proteinase A or saccharopepsin, MEROPS peptidase family A1). It belongs to MEROPS inhibitor family I34, clan JA. No other aspartic proteinase has been found to be inhibited by IA3, and at least...

[ "GO:0004866", "GO:0010951" ]

[ "endopeptidase inhibitor activity", "negative regulation of endopeptidase activity" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF10466" ]

[ "Inhibitor_I34" ]

[ 22 ]

1

[]

0

[ "1dp5", "1dpj", "1g0v" ]

3

[ "PUB00010637" ]

[ "11042188" ]

[ "The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae." ]

[ 2001 ]

1

[]

0

null

[ "Saccharomycetaceae" ]

[ 22 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Protease A inhibitor IA3

Pai3

2

IPR019508

19,508

Proteinase inhibitor I48, clitocypin

Prot_inh_I48_clitocypin

Family

169

false

Clitocypin binds and inhibits cysteine proteinases. It has no similarity to any other known cysteine proteinase inhibitors but bears some similarity to a lectin-like family of proteins from mushrooms [ ]. Insecticidal potential of clytocypins has been studied on colorado potato beetle, and thus, these are promising can...

[ "GO:0004869" ]

[ "cysteine-type endopeptidase inhibitor activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10467" ]

[ "Inhibitor_I48" ]

[ 169 ]

1

[]

0

[ "3h6r", "3h6s", "8ae4" ]

3

[ "PUB00044320", "PUB00099557" ]

[ "10748021", "26071808" ]

[ "Clitocypin, a new type of cysteine proteinase inhibitor from fruit bodies of mushroom clitocybe nebularis.", "Clitocypin, a fungal cysteine protease inhibitor, exerts its insecticidal effect on Colorado potato beetle larvae by inhibiting their digestive cysteine proteases." ]

[ 2000, 2015 ]

2

[]

0

null

[ "Agaricomycetes" ]

[ 169 ]

1

[]

0

true

Family

Proteinase inhibitor I48, clitocypin

Prot_inh_I48_clitocypin

6

IPR019509

19,509

Carboxypeptidase inhibitor I68

Carboxypeptidase_inhibitor_I68

Family

78

false

This entry represents a family of tick carboxypetidase inhibitors [ ]. They accelerates fibrinolysis and may contribute to the maintenance of host blood liquidity during feeding.

[ "GO:0008191", "GO:0007596", "GO:0010951" ]

[ "metalloendopeptidase inhibitor activity", "blood coagulation", "negative regulation of endopeptidase activity" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF10468" ]

[ "Inhibitor_I68" ]

[ 78 ]

1

[]

0

[ "1zlh", "1zli", "2jto", "2k2x", "2k2y", "2k2z", "3d4u", "3lms", "3osl" ]

9

[ "PUB00046979" ]

[ "15561703" ]

[ "A carboxypeptidase inhibitor from the tick Rhipicephalus bursa: isolation, cDNA cloning, recombinant expression, and characterization." ]

[ 2005 ]

1

[]

0

null

[ "Ixodoidea" ]

[ 78 ]

1

[]

0

true

Family

Carboxypeptidase inhibitor I68

Carboxypeptidase_inhibitor_I68

5

IPR019510

19,510

A-kinase anchor protein 7-like, phosphoesterase domain

AKAP7-like_phosphoesterase

Domain

7,788

false

This entry represents the phosphoesterase domain found in the cyclic AMP-dependent protein kinase A (PKA) anchor protein, AKAP7 (also known as AKAP18). This domain belongs to the 2H RNA-phosphoesterase family and contains two conserved His-x-Thr motifs which, from structural studies, it has been suggested to bind AMP a...

[]

0

[ "PFAM" ]

[ "PF10469" ]

[ "AKAP7_NLS" ]

[ 7788 ]

1

[ "REACTOME" ]

[ "R-HSA-112126" ]

[ "REACTOME:R-HSA-112126" ]

1

[ "2vfk", "2vfl", "2vfy", "3j4q", "3j4r", "5jj2", "6hiv", "6hiw", "6hiy", "7ane", "7aor", "7pub", "8tly", "8tuk" ]

14

[ "PUB00044142", "PUB00044143", "PUB00103503", "PUB00103506", "PUB00103510", "PUB00103512" ]

[ "12804576", "16483255", "29997253", "26924529", "27102985", "27487922" ]

[ "AKAP7gamma is a nuclear RI-binding AKAP.", "High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.", "RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage.", "Mu...

[ 2003, 2006, 2018, 2016, 2016, 2016 ]

6

[]

0

null

[ "Archaea", "Bacillus phage G", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 57, 1, 166, 7556, 8 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 20, 2, 15, 1, 17, 4, 1, 7, 10, 1, 10 ]

11

true

Domain

A-kinase anchor protein 7-like, phosphoesterase domain

AKAP7-like_phosphoesterase

3

IPR019511

19,511

A-kinase anchor protein 7, RI-RII subunit-binding domain

AKAP7_RI-RII-bd_dom

Domain

1,254

false

This entry represents the RI-RII subunit-binding domain found at the C-terminal of the cyclic AMP-dependent protein kinase A (PKA) anchor protein, AKAP7 (also known as AKAP18) [ ]. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its r...

[]

0

[ "PFAM" ]

[ "PF10470" ]

[ "AKAP7_RIRII_bdg" ]

[ 1254 ]

1

[]

0

[ "3j4q", "3j4r", "4zp3" ]

3

[ "PUB00044142", "PUB00044143", "PUB00103509", "PUB00103510" ]

[ "12804576", "16483255", "25653177", "27102985" ]

[ "AKAP7gamma is a nuclear RI-binding AKAP.", "High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.", "Hypothetical gene C18orf42 encodes a novel protein kinase A-binding protein.", "AKAP18:PKA-RIIα structure reveals crucial anchor points for recognit...

[ 2003, 2006, 2015, 2016 ]

4

[]

0

null

[ "Vertebrata" ]

[ 1254 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 3, 6 ]

4

true

Domain

A-kinase anchor protein 7, RI-RII subunit-binding domain

AKAP7_RI-RII-bd_dom

8

IPR019512

19,512

Protein phosphatase 1, regulatory subunit 15B, N-terminal

Prot_Pase1_reg-su15B_N

Domain

564

false

This entry represents the conserved N-terminal domain of the regulatory subunit (15B) of protein phosphatase 1 (also known as CReP, or the constitutive repressor of eIF2alpha phosphorylation). The CReP catalytic subunit functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In...

[]

0

[ "PFAM" ]

[ "PF10472" ]

[ "CReP_N" ]

[ 564 ]

1

[]

0

[]

0

[ "PUB00044212", "PUB00044213" ]

[ "14638860", "15355306" ]

[ "Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells.", "GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation." ]

[ 2003, 2005 ]

2

[]

0

null

[ "Euteleostomi" ]

[ 564 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 1, 3 ]

4

true

Domain

Protein phosphatase 1, regulatory subunit 15B, N-terminal

Prot_Pase1_reg-su15B_N

7

IPR019513

19,513

Centromere protein Cenp-F, leucine-rich repeat-containing domain

Centromere_CenpF_leu-rich_rpt

Domain

773

false

Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway [ , ]. There are several leucine-rich repeats along the sequence of LEK1 that are considered to be zippers, though they do not appear to b...

[ "GO:0008134", "GO:0042803", "GO:0070840" ]

[ "transcription factor binding", "protein homodimerization activity", "dynein complex binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PFAM" ]

[ "PF10473" ]

[ "CENP-F_leu_zip" ]

[ 773 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-156711", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025" ]

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-156711", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025" ]

7

[]

0

[ "PUB00044189", "PUB00044190" ]

[ "7542657", "14555653" ]

[ "CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.", "LEK1 is a potential inhibitor of pocket protein-mediated cellular processes." ]

[ 1995, 2004 ]

2

[]

0

null

[ "Bacteria", "Natronosalvus hydrolyticus", "Opisthokonta" ]

[ 119, 1, 653 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 4, 2 ]

4

true

Domain

Centromere protein Cenp-F, leucine-rich repeat-containing domain

Centromere_CenpF_leu-rich_rpt

9

IPR019514

19,514

Syndetin, C-terminal

Syndetin_C

Domain

3,575

false

The function of this domain is not known, but it is found at the C terminus of syndetin (VPS50), a unique component of the endosome-associated retrograde protein (EARP) complex. The EARP complex otherwise shares four of its five subunits with the Golgi-associated retrograde protein (GARP) complex. The EARP complex is l...

[]

0

[ "PFAM" ]

[ "PF10474" ]

[ "Syndetin_C" ]

[ 3575 ]

1

[]

0

[]

0

[ "PUB00077150" ]

[ "25799061" ]

[ "EARP is a multisubunit tethering complex involved in endocytic recycling." ]

[ 2015 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3575 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 4, 2, 5, 3, 4, 7, 15 ]

9

true

Domain

Syndetin, C-terminal

Syndetin_C

1

IPR019515

19,515

Vacuolar protein sorting-associated protein 54, N-terminal

VPS54_N

Domain

6,090

false

This entry represents a domain found in vacuolar protein sorting-associated protein 54 (VPS54), which acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). VPS54 is required to tether the complex to the TGN. However, it is not invo...

[]

0

[ "PFAM" ]

[ "PF10475" ]

[ "Vps54_N" ]

[ 6090 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6811440", "R-HSA-6811440", "R-MMU-6811440", "R-RNO-6811440" ]

[ "REACTOME:R-DME-6811440", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-6811440", "REACTOME:R-RNO-6811440" ]

4

[]

0

[ "PUB00077150" ]

[ "25799061" ]

[ "EARP is a multisubunit tethering complex involved in endocytic recycling." ]

[ 2015 ]

1

[]

0

null

[ "Eukaryota" ]

[ 6090 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 3, 5, 3, 12, 5, 4, 8, 19 ]

9

true

Domain

Vacuolar protein sorting-associated protein 54, N-terminal

VPS54_N

2

IPR019516

19,516

Glomulin/ALF4

Family

2,798

false

In the human adult, FKBP-12, also known as FAP68 or FK506-binding protein, (protein product of the gene glomulin) is expressed at high levels in skeletal muscle, heart, brain and kidney, and at low levels in smaller arteries and veins. The high expression of glomulin in murine vasculature suggests an important role in ...

[]

0

[ "PANTHER" ]

[ "PTHR15430" ]

[ "" ]

[ 2798 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-983168", "R-MMU-983168" ]

[ "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]

2

[ "4f52" ]

1

[ "PUB00044262", "PUB00044263", "PUB00044264", "PUB00053727" ]

[ "15053987", "11571281", "16278292", "14731255" ]

[ "Glomulin is predominantly expressed in vascular smooth muscle cells in the embryonic and adult mouse.", "Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor.", "In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin.", "Arabidopsis AL...

[ 2004, 2001, 2005, 2004 ]

4

[ "IPR013877" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2798 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 11, 7, 1, 4, 5, 3, 4, 1, 12 ]

9

true

Family

Glomulin/ALF4

6

IPR019517

19,517

Integrin binding protein, ICAP-1

Integrin-bd_ICAP-1

Family

1,261

false

ICAP-1 is a serine/threonine-rich protein that binds to the cytoplasmic domains of beta-1 integrins in a highly specific manner, binding to a NPXY sequence motif on the beta-1 integrin. The cytoplasmic domains of integrins are essential for cell adhesion, and the fact that phosphorylation of ICAP-1 by interaction with ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10480", "PTHR32055" ]

[ "ICAP-1_inte_bdg", "" ]

[ 1260, 1191 ]

2

[]

0

[ "4dx8", "4dx9", "4jif" ]

3

[ "PUB00044310", "PUB00044311", "PUB00044312" ]

[ "9281591", "11807099", "17567669" ]

[ "ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin.", "The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.", "Defective osteoblast functio...

[ 1997, 2002, 2007 ]

3

[]

0

null

[ "Metazoa" ]

[ 1261 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 13, 3, 4 ]

5

true

Family

Integrin binding protein, ICAP-1

Integrin-bd_ICAP-1

2

IPR019518

19,518

DNA endonuclease Ctp1, N-terminal

CtIP_N

Domain

1,784

false

CtIP is predominantly a nuclear protein that complexes with both BRCA1 and the BRCA1-associated RING domain protein (BARD1). At the protein level, CtIP expression varies with cell cycle progression in a pattern identical to that of BRCA1. Thus, the steady-state levels of CtIP polypeptides, which remain low in resting c...

[]

0

[ "PFAM" ]

[ "PF10482" ]

[ "CtIP_N" ]

[ 1784 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DRE-5693607", "R-HSA-5685938", "R-HSA-5685939", "R-HSA-5685942", "R-HSA-5693554", "R-HSA-5693568", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-8953750", "R-HSA-912446", "R-HSA-9701192", "R-HSA-9704331", "R-HSA-9704646", "R-HSA-9709570"...

[ "REACTOME:R-DRE-5693607", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685939", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693554", "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-5693579", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473", "REACTOME:...

36

[ "4d2h", "7bgf" ]

2

[ "PUB00044218", "PUB00044219" ]

[ "18007598", "17936710" ]

[ "A novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 gene.", "Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination." ]

[ 2007, 2007 ]

2

[]

0

null

[ "Desulfobacula toluolica (strain DSM 7467 / Tol2)", "Opisthokonta" ]

[ 1, 1783 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 10, 9, 7 ]

4

true

Domain

DNA endonuclease Ctp1, N-terminal

CtIP_N

5

IPR019519

19,519

Elongator complex protein 5

Elp5

Family

3,853

false

Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The human Elongator six-subunit complex, known as holo-Elongator, has histone acetyltransferase activity directed against histone H3 and H4 [ , ]. It consists of two subcomplexes, a core subcomplex (ELP1-3), and an accessory subcomplex (ELP4-6) [ ...

[ "GO:0002098", "GO:0033588" ]

[ "tRNA wobble uridine modification", "elongator holoenzyme complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF10483", "PTHR15641" ]

[ "Elong_Iki1", "" ]

[ 3287, 3752 ]

2

[ "REACTOME" ]

[ "R-HSA-3214847" ]

[ "REACTOME:R-HSA-3214847" ]

1

[ "4a8j", "4ejs", "8asv", "8at6" ]

4

[ "PUB00008616", "PUB00019998", "PUB00043577", "PUB00043578", "PUB00074321", "PUB00074325", "PUB00086633", "PUB00086635" ]

[ "10024884", "11689709", "11904415", "15769872", "11714725", "22556426", "22889844", "23165209" ]

[ "Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.", "Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae.", "Elongator is a histone H3 and H4 acetyltransferase im...

[ 1999, 2001, 2002, 2005, 2002, 2012, 2012, 2012 ]

8

[]

0

null

[ "Candidatus Methanofastidiosum methylothiophilum", "Eukaryota" ]

[ 1, 3852 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 12, 3, 1, 2, 5, 1, 1, 9 ]

12

true

Family

Elongator complex protein 5

Elp5

1

IPR019522

19,522

Phosphoinositide 3-kinase regulatory subunit 5/6

PIK3R5/6

Family

2,912

false

Phosphoinositide 3-kinase regulatory subunit5/6 are regulatory subunits of the PI3K gamma complex. Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways [ ].

[ "GO:0046935", "GO:0005944" ]

[ "1-phosphatidylinositol-3-kinase regulator activity", "phosphatidylinositol 3-kinase complex, class IB" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF10486", "PTHR15593" ]

[ "PI3K_1B_p101", "" ]

[ 2853, 2890 ]

2

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1758", "R-DDI-114604", "R-DDI-1660499", "R-DDI-392451", "R-HSA-114604", "R-HSA-1257604", "R-HSA-1660499", "R-HSA-2219530", "R-HSA-389357", "R-HSA-392451", "R-HSA-6811558", "R-HSA-9027276", "R-HSA-9927354", "R-MMU-114604", "R-MMU-1257604", "R-MMU-1660499", "R-MMU-389357", "R...

[ "GP:GenProp1758", "REACTOME:R-DDI-114604", "REACTOME:R-DDI-1660499", "REACTOME:R-DDI-392451", "REACTOME:R-HSA-114604", "REACTOME:R-HSA-1257604", "REACTOME:R-HSA-1660499", "REACTOME:R-HSA-2219530", "REACTOME:R-HSA-389357", "REACTOME:R-HSA-392451", "REACTOME:R-HSA-6811558", "REACTOME:R-HSA-90272...

21

[ "7mez", "8aj8", "8so9", "8soa", "8sob", "8soc", "8sod", "8soe" ]

8

[ "PUB00044437" ]

[ "11395417" ]

[ "Synthesis and function of 3-phosphorylated inositol lipids." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 2911, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 17, 10, 3, 11 ]

4

true

Family

Phosphoinositide 3-kinase regulatory subunit 5/6

PIK3R5/6

8

IPR019523

19,523

Protein phosphatase 1, regulatory subunit 15A/B, C-terminal

Prot_Pase1_reg-su15A/B_C

Domain

1,496

false

This entry represents the conserved C terminus of the regulatory subunit (15A and 15B) of protein phosphatase 1. This C-terminal domain appears to be a binding region for the catalytic subunit (PP1C) of protein phosphatase-1, which may in some circumstances also be retroviral in origin since it is found in both herpes ...

[]

0

[ "PFAM" ]

[ "PF10488" ]

[ "PP1c_bdg" ]

[ 1496 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2173788", "R-HSA-9648895" ]

[ "REACTOME:R-HSA-2173788", "REACTOME:R-HSA-9648895" ]

2

[ "4v0u", "4v0v", "4v0w", "4v0x", "7nzm", "9nb9" ]

6

[ "PUB00044212" ]

[ "14638860" ]

[ "Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells." ]

[ 2003 ]

1

[]

0

null

[ "Bilateria", "Viruses" ]

[ 1451, 45 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 8, 4, 7 ]

4

true

Domain

Protein phosphatase 1, regulatory subunit 15A/B, C-terminal

Prot_Pase1_reg-su15A/B_C

4

IPR019524

19,524

Beta-soilenoid domain, diatom-type

B-solenoid_diatom-type

Domain

93

false

This entry represents a domain found mainly in diatom proteins and is predicted to adopt a β-solenoid domain.

[]

0

[ "PANTHER" ]

[ "PTHR22534" ]

[ "" ]

[ 93 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 93 ]

1

[ "Homo sapiens" ]

[ 1 ]

1

true

Domain

Beta-soilenoid domain, diatom-type

B-solenoid_diatom-type

7

IPR019525

19,525

Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain

Nrf1_NLS/DNA-bd_dimer

Domain

2,676

false

Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for...

[]

0

[ "PFAM" ]

[ "PF10491" ]

[ "Nrf1_DNA-bind" ]

[ 2676 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1989781", "R-HSA-2151201", "R-HSA-9841251" ]

[ "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-9841251" ]

3

[ "8k3d", "8k4l" ]

2

[ "PUB00044398", "PUB00044399", "PUB00044400" ]

[ "10656923", "11069771", "11278998" ]

[ "Coding sequence, chromosomal localization, and expression pattern of Nrf1: the mouse homolog of Drosophila erect wing.", "Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila.", "Conserved regions of the Drosophila erect wing pr...

[ 2000, 2000, 2001 ]

3

[]

0

null

[ "Metazoa" ]

[ 2676 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 9, 2, 12, 10 ]

5

true

Domain

Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain

Nrf1_NLS/DNA-bd_dimer

5

IPR019527

19,527

RZZ complex, subunit KNTC1/ROD, C-terminal

RZZ-complex_KNTC1/ROD_C

Domain

1,827

false

Rod, the Rough deal protein (also known as Kinetochore-associated protein 1) displays a dynamic intracellular staining pattern, localising first to kinetochores in pro-metaphase, but moving to kinetochore microtubules at metaphase. Early in anaphase the protein is once again restricted to the kinetochores, where it per...

[]

0

[ "PFAM" ]

[ "PF10493" ]

[ "Rod_C" ]

[ 1827 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R-MMU-9648025" ]

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-MMU-5663220", "REACTOME:R-MMU-68877", "REACTOME:R-MM...

12

[ "7qpg" ]

1

[ "PUB00044468", "PUB00044469", "PUB00044470" ]

[ "10523511", "14711415", "15824131" ]

[ "The rough deal protein is a new kinetochore component required for accurate chromosome segregation in Drosophila.", "In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis.", "ZW10 links mitotic checkpoint signaling to the structural kinetochore." ]

[ 1999, 2004, 2005 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1827 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 6, 2, 3 ]

5

true

Domain

RZZ complex, subunit KNTC1/ROD, C-terminal

RZZ-complex_KNTC1/ROD_C

9

IPR019528

19,528

Pericentrin/AKAP-450 centrosomal targeting domain

PACT_domain

Domain

5,473

false

This entry represents a coiled-coil region close to the C terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C ...

[]

0

[ "PFAM" ]

[ "PF10495" ]

[ "PACT_coil_coil" ]

[ 5473 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5576890", "R-HSA-5576893", "R-HSA-5620912", "R-HSA-6802952", "R-HSA-8854518", "R-HSA-9613829", "R-HSA-9615710", "R-HSA-9646399", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-MMU-380284", ...

[ "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5576890", "REACTOME:R-HSA-5576893", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-6802952", "REACTOME:R-HSA-8854518", "REACTOME:R-HSA-9613829", "REACTOME:R-...

23

[]

0

[ "PUB00044416" ]

[ "11263498" ]

[ "The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5473 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 36, 14, 22, 8, 1, 13, 1 ]

7

true

Domain

Pericentrin/AKAP-450 centrosomal targeting domain

PACT_domain

6

IPR019530

19,530

Intra-flagellar transport protein 57

Intra-flagellar_transport_57

Family

2,455

false

Eukaryotic cilia and flagella are specialised organelles found at the periphery of cells of diverse organisms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bi-directional movement of large protein particles between the base and the di...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10498", "PTHR16011" ]

[ "IFT57", "" ]

[ 2428, 2313 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5620924", "R-DME-5610787", "R-DRE-5610787", "R-HSA-5610787", "R-HSA-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-XTR-5610787" ]

[ "REACTOME:R-CEL-5620924", "REACTOME:R-DME-5610787", "REACTOME:R-DRE-5610787", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5620924", "REACTOME:R-XTR-5610787" ]

8

[ "8bd7", "8ruy" ]

2

[ "PUB00044313" ]

[ "15955805" ]

[ "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2455 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 4, 3, 2 ]

6

true

Family

Intra-flagellar transport protein 57

Intra-flagellar_transport_57

9

IPR019531

19,531

Peroxisomal membrane protein 4

Pmp4

Family

2,869

false

Peroxisomes are single membrane bound organelles, present in practically all eukaryotic cells, and involved in a variety of metabolic pathways; the deduced protein is extremely basic, a characteristic of many other peroxisomal intrinsic membrane proteins. They carry two short stretches of hydrophobic residues shown to ...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF013674", "PTHR15460" ]

[ "PXMP4", "" ]

[ 2151, 2869 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9603798", "R-MMU-9603798", "R-RNO-9603798" ]

[ "REACTOME:R-HSA-9603798", "REACTOME:R-MMU-9603798", "REACTOME:R-RNO-9603798" ]

3

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2869 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 1, 4, 2, 1, 2 ]

6

true

Family

Peroxisomal membrane protein 4

Pmp4

8

IPR019533

19,533

Peptidase S26

Peptidase_S26

Domain

77,321

false

This entry represents a domain found in some members of the S26A family of serine endopeptidases. Peptidases S26A (signal peptidase I) removes the hydrophobic, N-terminal signal peptides as proteins are translocated across membranes. The type I signal peptidases are unique serine proteases that utilize a serine/lysine ...

[ "GO:0004252", "GO:0006465" ]

[ "serine-type endopeptidase activity", "signal peptide processing" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "CDD" ]

[ "PF10502", "cd06530" ]

[ "Peptidase_S26", "S26_SPase_I" ]

[ 64429, 70671 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.21.89", "R-BTA-422085", "R-BTA-9768727", "R-CFA-422085", "R-CFA-9768727", "R-HSA-1799339", "R-HSA-381771", "R-HSA-400511", "R-HSA-422085", "R-HSA-9760173", "R-HSA-9768727", "R-HSA-9828806", "R-MMU-422085", "R-MMU-9768727", "R-RNO-422085", "R-RNO-9768727" ]

[ "EC:3.4.21.89", "REACTOME:R-BTA-422085", "REACTOME:R-BTA-9768727", "REACTOME:R-CFA-422085", "REACTOME:R-CFA-9768727", "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-381771", "REACTOME:R-HSA-400511", "REACTOME:R-HSA-422085", "REACTOME:R-HSA-9760173", "REACTOME:R-HSA-9768727", "REACTOME:R-HSA-9828806...

16

[ "1b12", "1kn9", "1t7d", "3iiq", "3s04", "4k8w", "4me8", "4n31", "4nv4", "4wvg", "4wvh", "4wvi", "4wvj", "6b88", "7p2p", "7p2q" ]

16

[ "PUB00003576", "PUB00096998" ]

[ "7845208", "15546672" ]

[ "Families of serine peptidases.", "Type I signal peptidases of Gram-positive bacteria." ]

[ 1994, 2004 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 1877, 55646, 18672, 15, 7, 1104 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 45, 4, 6, 7, 1, 22, 12, 3, 33, 24, 2, 3, 90 ]

13

true

Domain

Peptidase S26

Peptidase_S26

7

IPR019534

19,534

Protein of unknown function DUF2452

DUF2452

Family

1,858

false

This entry contains proteins that have no known function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10504", "PTHR14553" ]

[ "DUF2452", "" ]

[ 1858, 1220 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 681, 1157, 10, 10 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 1, 1, 4 ]

6

true

Family

Protein of unknown function DUF2452

DUF2452

2

IPR019535

19,535

Little elongation complex subunit 2 , C-terminal

ICE2_C

Domain

1,820

false

This entry represents the C-terminal of little elongation complex subunit 2 (ICE2, also known as NARG2). ICE2 is a component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III [ , ]. This C-terminal domain belongs to the PD-(D...

[ "GO:0008023" ]

[ "transcription elongation factor complex" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF10505" ]

[ "NARG2_C" ]

[ 1820 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

2

[]

0

[ "PUB00066699", "PUB00072917", "PUB00072918" ]

[ "22638584", "23932780", "22195968" ]

[ "Sequence, structure and functional diversity of PD-(D/E)XK phosphodiesterase superfamily.", "The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.", "The little elongation complex regulates small nuclear RNA transcription." ]

[ 2012, 2013, 2011 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1820 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 1, 5 ]

5

true

Domain

Little elongation complex subunit 2 , C-terminal

ICE2_C

4

IPR019536

19,536

Harmonin-binding protein USHBP1, PDZ-binding domain

USHBP1_PDZ-bd

Domain

2,370

false

The entry represents the PDZ-binding domain of Harmonin-binding protein USHBP1 (also known as MCC2, mutated in colon cancer-2). USHBP1 has high homology to tumour suppressor MCC1 (mutated in colon cancer-1). MCC2 protein binds the first PDZ domain of AIE-75 (also known as Harmonin) with its C-terminal amino acids -DTFL...

[]

0

[ "PFAM" ]

[ "PF10506" ]

[ "USHBP1_PDZ-bd" ]

[ 2370 ]

1

[]

0

[]

0

[ "PUB00045022", "PUB00045023" ]

[ "11311560", "15219944" ]

[ "Interaction of MCC2, a novel homologue of MCC tumor suppressor, with PDZ-domain Protein AIE-75.", "Expression of AIE-75 PDZ-domain protein induces G2/M cell cycle arrest in human colorectal adenocarcinoma SW480 cells." ]

[ 2001, 2004 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 2370 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 17, 6, 10, 4, 10 ]

5

true

Domain

Harmonin-binding protein USHBP1, PDZ-binding domain

USHBP1_PDZ-bd

2

IPR019538

19,538

26S proteasome non-ATPase regulatory subunit 5

PSMD5

Family

3,146

false

The 26S proteasome is an enzymatic complex that degrades ubiquitinated proteins in eukaryotic cells. 26S proteasome non-ATPase regulatory subunit 5 (PSMD5) is one of a number of chaperones that are involved in the assembly of the proteasome. The chaperones dissociate before 26S proteasome formation is complete [ ]. TNF...

[ "GO:0043248" ]

[ "proteasome assembly" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10508", "PTHR13554" ]

[ "Proteasom_PSMB", "" ]

[ 2960, 2961 ]

2

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp2012", "R-DME-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-SPO-9907900" ]

[ "GP:GenProp2012", "REACTOME:R-DME-9907900", "REACTOME:R-HSA-9907900", "REACTOME:R-MMU-9907900", "REACTOME:R-SPO-9907900" ]

5

[]

0

[ "PUB00055592", "PUB00072163" ]

[ "19490896", "22921402" ]

[ "Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.", "Role of S5b/PSMD5 in proteasome inhibition caused by TNF-α/NFκB in higher eukaryotes." ]

[ 2009, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3146 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 7, 1, 3, 8, 4, 3, 2, 6, 1, 9 ]

10

true

Family

26S proteasome non-ATPase regulatory subunit 5

PSMD5

9

IPR019539

19,539

Galactokinase, N-terminal domain

GalKase_N

Domain

22,540

false

This entry represents an N-terminal conserved domain found in all galactokinases, irrespective of how many other ATP binding sites, etc that they carry [ ]. The function of this domain appears to be to bind galactose [ ], and it is normally located at the N terminus of these enzymes [ ]. It is associated with and . Whi...

[]

0

[ "PFAM" ]

[ "PF10509" ]

[ "GalKase_gal_bdg" ]

[ 22540 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1.6", "GenProp1330", "PWY-3821", "PWY-6317", "PWY-6527", "R-BTA-70370", "R-CFA-70370", "R-HSA-5609976", "R-HSA-70370", "R-MMU-70370" ]

[ "EC:2.7.1.6", "GP:GenProp1330", "METACYC:PWY-3821", "METACYC:PWY-6317", "METACYC:PWY-6527", "REACTOME:R-BTA-70370", "REACTOME:R-CFA-70370", "REACTOME:R-HSA-5609976", "REACTOME:R-HSA-70370", "REACTOME:R-MMU-70370" ]

10

[ "1pie", "1s4e", "1wuu", "2a2c", "2a2d", "2aj4", "2cz9", "2dei", "2dej", "3v2u", "3v5r", "6gr2", "6q3w", "6q3x", "6q8z", "6q90", "6q91", "6qje", "6tep", "6teq", "6ter", "6zfh", "6zgv", "6zgw", "6zgx", "6zgy", "6zgz", "6zh0", "7ozx", "7rcl", "7rcm", "7s49"...

33

[ "PUB00015835", "PUB00044187", "PUB00044277", "PUB00094344" ]

[ "12796487", "10359639", "15526155", "10344205" ]

[ "Molecular structure of galactokinase.", "The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core.", "Galactokinase: structure, function and role in type II galactosemia.", "The arabinose kinase, ARA1, gene of Arabidopsis is a novel me...

[ 2003, 1999, 2004, 1999 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctmP19", "unclassified sequences" ]

[ 338, 14621, 7355, 1, 225 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 13, 1, 2, 1, 1, 17, 12, 1, 4, 13, 2, 1, 21 ]

13

true

Domain

Galactokinase, N-terminal domain

GalKase_N

2

IPR019540

19,540

Phosphatidylinositol-glycan biosynthesis class S protein

PtdIno-glycan_biosynth_class_S

Family

4,679

false

Phosphatidylinositol-glycan biosynthesis class S protein (PIG-S, also known as Gpi17 in budding yeasts) is one of several key, core components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that adds GPIs to newly synthesized proteins [ ]. Mammalian GPI transamidase consists of at least five components...

[ "GO:0016255", "GO:0042765" ]

[ "attachment of GPI anchor to protein", "GPI-anchor transamidase complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF10510", "PTHR21072" ]

[ "PIG-S", "" ]

[ 4667, 4486 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-162791", "R-MMU-162791", "R-RNO-162791" ]

[ "REACTOME:R-HSA-162791", "REACTOME:R-MMU-162791", "REACTOME:R-RNO-162791" ]

3

[ "7w72", "7wld", "8imx", "8imy" ]

4

[ "PUB00009845", "PUB00044439" ]

[ "11598210", "14660601" ]

[ "The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p.", "A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase." ]

[ 2001, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4679 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 4, 3, 26, 5, 1, 5, 2, 1, 2, 4 ]

12

true

Family

Phosphatidylinositol-glycan biosynthesis class S protein

PtdIno-glycan_biosynth_class_S

9

IPR019541

19,541

Trappin protein transglutaminase-binding repeat

Trappin_transglut-bd_rpt

Repeat

536

false

Trappin-2,a protease inhibitor, has a unique N-terminal domain that enables it to become cross-linked to extracellular matrix proteins by transglutaminase [ ]. This domain contains several repeated motifs (represented by this entry) with the consensus sequence Gly-Gln-Asp-Pro-Val-Lys, and these together can anchor the ...

[]

0

[ "PFAM" ]

[ "PF10511" ]

[ "Cementoin" ]

[ 536 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6803157", "R-HSA-6809371", "R-SSC-6803157", "R-SSC-6809371" ]

[ "REACTOME:R-HSA-6803157", "REACTOME:R-HSA-6809371", "REACTOME:R-SSC-6803157", "REACTOME:R-SSC-6809371" ]

4

[]

0

[ "PUB00044187", "PUB00044188" ]

[ "10359639", "17964057" ]

[ "The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core.", "Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family." ]

[ 1999, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Lymphocystis disease virus 2" ]

[ 59, 475, 2 ]

3

[ "Homo sapiens" ]

[ 1 ]

1

true

Repeat

Trappin protein transglutaminase-binding repeat

Trappin_transglut-bd_rpt

3

IPR019543

19,543

Beta-amyloid precursor protein C-terminal

APP_amyloid_C

Domain

6,278

false

This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into ...

[]

0

[ "PFAM" ]

[ "PF10515" ]

[ "APP_amyloid" ]

[ 6278 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-114608", "R-CEL-3000178", "R-CEL-381426", "R-CEL-416476", "R-CEL-8957275", "R-CEL-9609523", "R-DME-114608", "R-DME-3000178", "R-DME-381426", "R-DME-416476", "R-DME-8957275", "R-DME-9609523", "R-DME-9837999", "R-HSA-114608", "R-HSA-3000178", "R-HSA-381426", "R-HSA-416476", "R...

[ "REACTOME:R-CEL-114608", "REACTOME:R-CEL-3000178", "REACTOME:R-CEL-381426", "REACTOME:R-CEL-416476", "REACTOME:R-CEL-8957275", "REACTOME:R-CEL-9609523", "REACTOME:R-DME-114608", "REACTOME:R-DME-3000178", "REACTOME:R-DME-381426", "REACTOME:R-DME-416476", "REACTOME:R-DME-8957275", "REACTOME:R-DM...

67

[ "1x11", "2lp1", "2roz", "2ysz", "2yt0", "2yt1", "3dxc", "3dxd", "3dxe", "3sv1", "6itu", "6iyc", "8kew", "8kf1", "8kf3", "8kf4", "8kf5", "8kf6", "8otf", "8x52", "8x54" ]

21

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 6278 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 16, 6, 22, 20, 17 ]

6

true

Domain

Beta-amyloid precursor protein C-terminal

APP_amyloid_C

8

IPR019544

19,544

Tetratricopeptide, SHNi-TPR domain

Tetratricopeptide_SHNi-TPR_dom

Domain

4,120

false

The tetratrico peptide repeat region (TPR) is a structural motif present in a wide range of proteins [ , , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes [ ]. The TPR motif consists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed...

[]

0

[ "PFAM" ]

[ "PF10516" ]

[ "SHNi-TPR" ]

[ 4120 ]

1

[]

0

[ "7v1k", "7v1l", "7v1m", "7v6p", "7v6q", "7w5m" ]

6

[ "PUB00001313", "PUB00005443", "PUB00005695", "PUB00014195", "PUB00044489" ]

[ "9482716", "7667876", "1882418", "14659697", "18158900" ]

[ "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.", "Tetratrico peptide repeat interactions: to TPR or not to TPR?", "The TPR snap helix: a novel protein repeat motif from mitosis to transcription.", "TPR proteins: the versati...

[ 1998, 1995, 1991, 2003, 2007 ]

5

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 24, 4096 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6, 2, 4, 10, 3, 1, 4, 6, 1 ]

9

true

Domain

Tetratricopeptide, SHNi-TPR domain

Tetratricopeptide_SHNi-TPR_dom

5

IPR019545

19,545

DM13 domain

DM13_domain

Domain

6,067

false

The DM13 domain has been identified in animal proteins containing a DOMON domain likely to function as cytochromes involved in as yet unidentified redox reactions potentially related to protein hydroxylation or oxidative cross-linking. However, it is also found in bacteria. The DM13 domain contains a nearly absolutely ...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF10517", "PS51549", "SM00686" ]

[ "DM13", "DM13", "DM13" ]

[ 5669, 6041, 2725 ]

3

[]

0

[]

0

[ "PUB00044228" ]

[ "17878204" ]

[ "The DOMON domains are involved in heme and sugar recognition." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Nitrosopumivirus cobalaminus", "ecological metagenomes" ]

[ 47, 3063, 2945, 1, 11 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Drosophila melanogaster", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 4, 8, 5, 6 ]

5

true

Domain

DM13 domain

DM13_domain

6

IPR019546

19,546

Twin-arginine translocation pathway, signal sequence, bacterial/archaeal

TAT_signal_bac_arc

Conserved_site

70,736

false

The twin-arginine translocation (Tat) pathway serves the role of transporting folded proteins across energy-transducing membranes [ ]. Homologues of the genes that encode the transport apparatus occur in archaea, bacteria, chloroplasts, and plant mitochondria [ ]. In bacteria, the Tat pathway catalyses the export of pr...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF10518", "TIGR01409" ]

[ "TAT_signal", "TAT_signal_seq" ]

[ 8970, 67682 ]

2

[ "GP" ]

[ "GenProp0127" ]

[ "GP:GenProp0127" ]

1

[ "1h2a", "1hfe", "1zrt", "2fyn", "2ivf", "2pq4", "2qjk", "2qjp", "2qjy", "2vpw", "2vpx", "2vpy", "2vpz", "2wpn", "2yiu", "3sbp", "3sbq", "3sbr", "5f75", "5jsh", "5jsk", "5jsu", "5jsy", "5jt1", "5kkz", "5kli", "6i3q", "6nhh", "6nin", "6rkz", "6rl0", "6rrp"...

94

[ "PUB00043729", "PUB00043730", "PUB00043731", "PUB00043732", "PUB00043733", "PUB00043734", "PUB00043735" ]

[ "16322447", "12029389", "16092521", "16756481", "15546663", "15802249", "12427925" ]

[ "Protein translocation across biological membranes.", "Sequence and phylogenetic analyses of the twin-arginine targeting (Tat) protein export system.", "Sec-dependent protein translocation across biological membranes: evolutionary conservation of an essential protein transport pathway (review).", "The bacteri...

[ 2005, 2002, 2005, 2006, 2004, 2005, 2002 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2391, 66827, 289, 5, 1224 ]

5

[ "Escherichia coli (strain K12)" ]

[ 9 ]

1

true

Conserved_site

Twin-arginine translocation pathway, signal sequence, bacterial/archaeal

TAT_signal_bac_arc

6

IPR019547

19,547

Lipid desaturase domain

Lipid_desat

Domain

4,771

false

This entry represents lipid desaturase domains. The TMEM189 protein is a plasmanylethanolamine desaturase enzyme [ , ]. It was previously described as the B domain or probable localisation domain of the transmembrane protein TMEM189 [ ] which in some mammals is fused with Kua ubiquitin-conjugation E2 enzyme proteins [ ...

[]

0

[ "PFAM" ]

[ "PF10520" ]

[ "Lipid_desat" ]

[ 4771 ]

1

[]

0

[]

0

[ "PUB00044324", "PUB00072486", "PUB00072488", "PUB00098459", "PUB00098460" ]

[ "11076860", "20420830", "19682287", "32209662", "31604315" ]

[ "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene.", "Recruitment of Uev1B to Hrs-containing endosomes and its effect on endosomal trafficking.", "FATTY ACID DESATURASE4 of Arabidopsis encodes a protein distinct from characterized fatty acid desaturases.", ...

[ 2000, 2010, 2009, 2020, 2019 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 276, 4440, 36, 19 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 13, 1, 3, 1, 3, 2, 2, 4, 3 ]

9

true

Domain

Lipid desaturase domain

Lipid_desat

4

IPR019548

19,548

CTF transcription factor/nuclear factor 1, N-terminal

CTF/NFI_DNA-bd_N

Domain

9,482

false

Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [ , , ] (also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initia...

[]

0

[ "PFAM" ]

[ "PF10524" ]

[ "NfI_DNAbd_pre-N" ]

[ 9482 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-73980", "R-HSA-749476" ]

[ "REACTOME:R-HSA-73980", "REACTOME:R-HSA-749476" ]

2

[ "7qqd", "7qqe", "9qky" ]

3

[ "PUB00000833", "PUB00001922", "PUB00004374", "PUB00004597", "PUB00097185", "PUB00097186" ]

[ "2504497", "8543151", "2339052", "6216480", "19584245", "28962832" ]

[ "The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain.", "A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.", "Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with h...

[ 1989, 1995, 1990, 1982, 2009, 2017 ]

6

[]

0

null

[ "Metazoa" ]

[ 9482 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 138, 2, 46, 28, 40 ]

6

true

Domain

CTF transcription factor/nuclear factor 1, N-terminal

CTF/NFI_DNA-bd_N

2

IPR019549

19,549

Homeobox engrailed, C-terminal

Homeobox-engrailed_C-terminal

Domain

2,333

false

Homeodomain proteins are transcription factors that share a related DNA-binding homeodomain [ ]. The homeodomain was initially identified in Drosophila melanogaster (Fruit fly) homeotic and segmentation proteins, but is well conserved throughout metazoans [ , ]. The homeodomain binds DNA through a helix-turn-helix (HTH...

[]

0

[ "PFAM" ]

[ "PF10525" ]

[ "Engrail_1_C_sig" ]

[ 2333 ]

1

[]

0

[]

0

[ "PUB00000591", "PUB00003347", "PUB00004373", "PUB00005101", "PUB00005390", "PUB00010002", "PUB00013192", "PUB00013193", "PUB00013194" ]

[ "2568852", "7707374", "1970866", "2884726", "1357790", "12445403", "10377888", "12215502", "9739097" ]

[ "The structure and function of the homeodomain.", "The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance.", "Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a.", "Homeo boxes in the study of development.", "T...

[ 1989, 1995, 1990, 1987, 1992, 2002, 1999, 2002, 1998 ]

9

[]

0

null

[ "Bilateria" ]

[ 2333 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 5, 2, 3, 4 ]

5

true

Domain

Homeobox engrailed, C-terminal

Homeobox-engrailed_C-terminal

5

IPR019552

19,552

Histidine-rich calcium-binding

Hist_rich_Ca-bd

Repeat

218

false

This entry represents a histidine-rich calcium-binding repeat which appears in proteins called histidine-rich-calcium binding proteins (HRC). HRC is a high capacity, low affinity Ca2+-binding protein, residing in the lumen of the sarcoplasmic reticulum. HRC binds directly to triadin. This binding interaction occurs bet...

[]

0

[ "PFAM" ]

[ "PF10529" ]

[ "Hist_rich_Ca-bd" ]

[ 218 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-381426", "R-HSA-8957275" ]

[ "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275" ]

2

[]

0

[ "PUB00044302" ]

[ "15777620" ]

[ "Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein." ]

[ 2005 ]

1

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 2, 216 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 4, 6 ]

3

true

Repeat

Histidine-rich calcium-binding

Hist_rich_Ca-bd

3

IPR019553

19,553

Spider toxin CSTX, Knottin scaffold

Spider_toxin_CSTX_knottin

Family

468

false

Spider toxins of the CSTX family are ion channel toxins containing an inhibitor cystine knot (ICK) structural motif or Knottin scaffold. The four disulphide bonds present in the CSTX spider toxin family are arranged in the following pattern: 1-4, 2-5, 3-8 and 6-7. CSTX-1 is the most important component of Cupiennius sa...

[ "GO:0090729" ]

[ "toxin activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10530" ]

[ "Toxin_35" ]

[ 468 ]

1

[]

0

[ "2mzf", "2mzg" ]

2

[ "PUB00044520", "PUB00085657", "PUB00097256", "PUB00097257", "PUB00097258" ]

[ "17517422", "20657014", "32290562", "22613721", "24717175" ]

[ "CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons.", "Novel class of spider toxin: active principle from the yellow sac spider Cheiracanthium punctorium venom is a unique two-domain polypeptide.", "Neurotoxin Merging: A...

[ 2007, 2010, 2020, 2012, 2014 ]

5

[]

0

null

[ "Araneomorphae" ]

[ 468 ]

1

[]

0

true

Family

Spider toxin CSTX, Knottin scaffold

Spider_toxin_CSTX_knottin

7

IPR019554

19,554

Soluble ligand binding domain

Soluble_ligand-bd

Domain

42,144

false

The soluble ligand-binding β-grasp domain (SLBB) contains a β-grasp fold. They are found in a diverse set of proteins that include the animal vitamin B12 uptake proteins; transcobalamin, intrinsic factor and the bacterial polysaccharide export proteins [ ]. Some proteins may be part of a membrane complex involved in el...

[]

0

[ "PFAM" ]

[ "PF10531" ]

[ "SLBB" ]

[ 42144 ]

1

[]

0

[ "2fug", "2ybb", "3i9v", "3iam", "3ias", "3m9s", "4hea", "6hl2", "6hl3", "6hl4", "6hla", "6hli", "6hlj", "6hlm", "6i0d", "6i1p", "6q8o", "6q8w", "6q8x", "6q9c", "6q9g", "6q9j", "6q9k", "6r7p", "6saq", "6ttl", "6y11", "6ziy", "6zjl", "6zjn", "6zjy", "7e5z"...

87

[ "PUB00044948" ]

[ "17250770" ]

[ "A novel superfamily containing the beta-grasp fold involved in binding diverse soluble ligands." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 81, 41022, 48, 993 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Soluble ligand binding domain

Soluble_ligand-bd

4

IPR019559

19,559

Cullin, neddylation domain

Cullin_neddylation_domain

Domain

26,104

false

This is the neddylation site of cullin proteins, which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which...

[]

0

[ "PFAM", "SMART" ]

[ "PF10557", "SM00884" ]

[ "Cullin_Nedd8", "Cullin_Nedd8" ]

[ 24445, 26055 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "GenProp1311", "GenProp1754", "R-CEL-110314", "R-CEL-1234176", "R-CEL-187577", "R-CEL-195253", "R-CEL-2565942", "R-CEL-4641258", "R-CEL-5632684", "R-CEL-5696394", "R-CEL-5696395", "R-CEL-5696400", "R-CEL-6781823", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-68949", "R-CEL-69231", "R-C...

[ "GP:GenProp1311", "GP:GenProp1754", "REACTOME:R-CEL-110314", "REACTOME:R-CEL-1234176", "REACTOME:R-CEL-187577", "REACTOME:R-CEL-195253", "REACTOME:R-CEL-2565942", "REACTOME:R-CEL-4641258", "REACTOME:R-CEL-5632684", "REACTOME:R-CEL-5696394", "REACTOME:R-CEL-5696395", "REACTOME:R-CEL-5696400", ...

198

[ "1iuy", "1ldj", "1ldk", "1u6g", "2do7", "2hye", "3dpl", "3dqv", "3o2p", "3o6b", "3rtr", "3tdu", "3tdz", "4a0c", "4a0k", "4a0l", "4p5o", "5n4w", "5v89", "6r6h", "6r7f", "6r7i", "6r7n", "6ttu", "6v9i", "7b5l", "7b5m", "7b5n", "7b5r", "7b5s", "7okq", "7oni"...

106

[ "PUB00044220" ]

[ "15021886" ]

[ "Nedd8 on cullin: building an expressway to protein destruction." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota", "Viruses", "metagenomes" ]

[ 26099, 2, 3 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 23, 9, 30, 11, 47, 26, 3, 20, 40, 3, 3, 51 ]

12

true

Domain

Cullin, neddylation domain

Cullin_neddylation_domain

6

IPR019560

19,560

Mitochondrial 18kDa protein

Mitochondrial_18_kDa_protein_

Family

3,207

false

This family of proteins are mitochondrial 18kDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis [ ]. Over expression studies suggest that MTP18 is required for mitochondrial ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10558", "PTHR11001" ]

[ "MTP18", "" ]

[ 3143, 3160 ]

2

[]

0

[]

0

[ "PUB00044383", "PUB00044384" ]

[ "15155745", "15985469" ]

[ "Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis.", "The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells." ]

[ 2004, 2005 ]

2

[]

0

null

[ "Eukaryota", "Viruses" ]

[ 3178, 29 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 2, 1, 4, 2, 1, 4 ]

7

true

Family

Mitochondrial 18kDa protein

Mitochondrial_18_kDa_protein_

7

IPR019561

19,561

Translocon Sec61/SecY, plug domain

Translocon_Sec61/SecY_plug_dom

Domain

8,549

false

The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side. The plug is unlikely to be important for sealing the translocation pore in yeast but...

[]

0

[ "PFAM" ]

[ "PF10559" ]

[ "Plug_translocon" ]

[ 8549 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-1236974", "R-HSA-1799339" ]

[ "REACTOME:R-HSA-1236974", "REACTOME:R-HSA-1799339" ]

2

[ "1rh5", "1rhz", "2ww9", "2wwa", "2wwb", "3bo0", "3bo1", "3dkn", "3j7q", "3j7r", "3jc2", "3mp7", "4cg5", "4cg6", "4cg7", "4v4n", "4v7i", "5a6u", "6ftg", "6fti", "6ftj", "6n3q", "6nd1", "6r7q", "6w6l", "6z3t", "7aft", "7kah", "7kai", "7kaj", "7kak", "7kal"...

68

[ "PUB00044440" ]

[ "16822836" ]

[ "The plug domain of yeast Sec61p is important for efficient protein translocation, but is not essential for cell viability." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 865, 4, 7642, 38 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 2, 3, 2, 19, 6, 1, 15, 9, 2, 2, 15 ]

12

true

Domain

Translocon Sec61/SecY, plug domain

Translocon_Sec61/SecY_plug_dom

3

IPR019562

19,562

Micronemal adhesive repeat, sialic-acid binding

Micronemal-adhesive-rpt_sia-bd

Repeat

184

false

This entry represents a novel carbohydrate-binding domain found on micronemal proteins. Micronemal proteins (MICs) are released onto the parasite surface just before invasion of host cells and play important roles in host cell recognition, attachment and penetration. Toxoplasma gondii can infect and replicate within al...

[]

0

[ "PFAM" ]

[ "PF10564" ]

[ "MAR_sialic_bdg" ]

[ 184 ]

1

[]

0

[ "2jh1", "2jh7", "2jhd", "2lbo", "3f53", "3f5a", "3f5e" ]

7

[ "PUB00044345", "PUB00044346" ]

[ "17491595", "18203663" ]

[ "Atomic resolution insight into host cell recognition by Toxoplasma gondii.", "MARveling at parasite invasion." ]

[ 2007, 2008 ]

2

[]

0

null

[ "Eukaryota" ]

[ 184 ]

1

[]

0

true

Repeat

Micronemal adhesive repeat, sialic-acid binding

Micronemal-adhesive-rpt_sia-bd

9

IPR019563

19,563

Glycosyl-hydrolase 97, catalytic domain

GH97_catalytic

Domain

9,203

false

Proteins containing this domain include the aglycoside hydrolase family 97 enzyme, SusB protein, from Bacteroides thetaiotaomicron. SusB has three domains: the N-terminal, catalytic, and C-terminal domains. This entry represents the catalytic domain that consists of a complete (β/α)8-barrel or TIM-barrel. The N- and C-...

[]

0

[ "PFAM" ]

[ "PF10566" ]

[ "Glyco_hydro_97" ]

[ 9203 ]

1

[]

0

[ "2d73", "2jka", "2jke", "2jkp", "2zq0", "3a24", "3wfa", "5e1q", "5hq4", "5hqa", "5hqb", "5hqc", "5xfm", "8wg0", "8wg1", "8wg2", "9bs5" ]

17

[ "PUB00047951", "PUB00052647" ]

[ "18848471", "18981178" ]

[ "Divergence of catalytic mechanism within a glycosidase family provides insight into evolution of carbohydrate metabolism by human gut flora.", "Structural and functional analysis of a glycoside hydrolase family 97 enzyme from Bacteroides thetaiotaomicron." ]

[ 2008, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Siphoviridae sp. ctYaH2", "unclassified sequences" ]

[ 8900, 59, 148, 1, 95 ]

5

[]

0

true

Domain

Glycosyl-hydrolase 97, catalytic domain

GH97_catalytic

9

IPR019564

19,564

Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain

Sam37/metaxin_N

Domain

6,239

false

Sam37 (also known as TOM37) is a component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as β-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex [ ]. It has homology wit...

[ "GO:0001401" ]

[ "SAM complex" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF10568" ]

[ "Tom37" ]

[ 6239 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-9013404", "R-DME-9013404", "R-HSA-1268020", "R-HSA-8949613", "R-HSA-9013404", "R-MMU-9013404", "R-SSC-9013404" ]

[ "REACTOME:R-CEL-9013404", "REACTOME:R-DME-9013404", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-8949613", "REACTOME:R-HSA-9013404", "REACTOME:R-MMU-9013404", "REACTOME:R-SSC-9013404" ]

7

[ "6wuh", "6wuj", "6wul", "6wum", "6wut", "7btw", "7btx", "7bty", "7e4h", "7e4i", "7vku" ]

11

[ "PUB00044518", "PUB00045326", "PUB00062990" ]

[ "17981999", "9045676", "12891361" ]

[ "Functional definition of outer membrane proteins involved in preprotein import into mitochondria.", "Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion.", "Machinery for protein sorting and assembly in the mitochondrial outer membrane." ]

[ 2007, 1997, 2003 ]

3

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 6238, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 5, 10, 6, 16, 1, 14, 1, 1 ]

9

true

Domain

Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain

Sam37/metaxin_N

9

IPR019566

19,566

Myelin protein P0, C-terminal

MYP0_C

Domain

350

false

The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. Myelin protein P0 (MYP0), is a major component of the myelin sheath in peripheral nerves [ ]. It comprises a an immunoglobulin (Ig)-like extracellula...

[]

0

[ "PFAM" ]

[ "PF10570" ]

[ "Myelin-PO_C" ]

[ 350 ]

1

[ "REACTOME" ]

[ "R-HSA-9619665" ]

[ "REACTOME:R-HSA-9619665" ]

1

[]

0

[ "PUB00000799", "PUB00002447", "PUB00065458", "PUB00078620", "PUB00099903", "PUB00099904", "PUB00099905", "PUB00099908", "PUB00099911" ]

[ "2578885", "2435734", "21971831", "17502419", "30679613", "18337304", "10545037", "30755303", "31173589" ]

[ "Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin.", "Complete amino acid sequence of PO protein in bovine peripheral nerve myelin.", "Crystal structure of the extracellular domain of human myelin protein zero.", "Myelin protein zero/P0 phosphorylation and function r...

[ 1985, 1987, 2012, 2007, 2019, 2008, 1999, 2019, 2019 ]

9

[]

0

null

[ "Gnathostomata" ]

[ 350 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 3, 6 ]

3

true

Domain

Myelin protein P0, C-terminal

MYP0_C

1

IPR019568

19,568

Rapsyn, myristoylation/linker region, N-terminal

Rapsyn_myristoylation/link_N

Domain

1,532

false

Neuromuscular junction formation relies upon the clustering of acetylcholine receptors and other proteins in the muscle membrane. Rapsyn (receptor-associated protein of the synapse) is a peripheral membrane protein that is selectively concentrated at the neuromuscular junction (NMJ) and is essential for the formation o...

[ "GO:0033130", "GO:0043495", "GO:0007268" ]

[ "acetylcholine receptor binding", "protein-membrane adaptor activity", "chemical synaptic transmission" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF10579" ]

[ "Rapsyn_N" ]

[ 1532 ]

1

[]

0

[]

0

[ "PUB00044454", "PUB00073773" ]

[ "15730871", "19344765" ]

[ "Deletion of N-terminal rapsyn domains disrupts clustering and has dominant negative effects on clustering of full-length rapsyn.", "Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding." ]

[ 2005, 2009 ]

2

[]

0

null

[ "Bacteria", "Eumetazoa" ]

[ 20, 1512 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 8, 3, 5 ]

6

true

Domain

Rapsyn, myristoylation/linker region, N-terminal

Rapsyn_myristoylation/link_N

1

IPR019570

19,570

Connexin, cysteine-rich domain

Connexin_CCC

Domain

20,479

false

This entry represents the cysteine rich domain of the connexins. Two sets of nomenclature have been used to identify the connexins. The first, and most commonly used, classifies the connexin molecules according to molecular weight, such as connexin43 (abbreviated to Cx43), indicating a connexin of molecular weight clos...

[]

0

[ "SMART" ]

[ "SM01089" ]

[ "Connexin_CCC" ]

[ 20479 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-112303", "R-BTA-190704", "R-BTA-190840", "R-BTA-190861", "R-BTA-190872", "R-BTA-190873", "R-BTA-191650", "R-BTA-196025", "R-BTA-9013406", "R-CFA-190861", "R-DRE-190840", "R-DRE-190861", "R-DRE-191650", "R-DRE-9013406", "R-GGA-112303", "R-GGA-190861", "R-GGA-190872", "R-HSA-1...

[ "REACTOME:R-BTA-112303", "REACTOME:R-BTA-190704", "REACTOME:R-BTA-190840", "REACTOME:R-BTA-190861", "REACTOME:R-BTA-190872", "REACTOME:R-BTA-190873", "REACTOME:R-BTA-191650", "REACTOME:R-BTA-196025", "REACTOME:R-BTA-9013406", "REACTOME:R-CFA-190861", "REACTOME:R-DRE-190840", "REACTOME:R-DRE-19...

52

[ "2zw3", "3iz1", "3iz2", "5er7", "5era", "6l3t", "6l3u", "6l3v", "6mhq", "6mhy", "6uvr", "6uvs", "6uvt", "7f92", "7f93", "7f94", "7jjp", "7jkc", "7jlw", "7jm9", "7jmc", "7jmd", "7jn0", "7jn1", "7qeo", "7qeq", "7qer", "7qes", "7qet", "7qeu", "7qev", "7qew"...

84

[ "PUB00000087", "PUB00000926", "PUB00005237", "PUB00005511", "PUB00005532", "PUB00005545", "PUB00005549" ]

[ "8811187", "8608591", "1320430", "9861669", "9769729", "7685944", "7570999" ]

[ "Connexins, connexons, and intercellular communication.", "The gap junction communication channel.", "Molecular biology and genetics of gap junction channels.", "Diverse functions of vertebrate gap junctions.", "Innexins: a family of invertebrate gap-junction proteins.", "Gap junctions in the brain: where...

[ 1996, 1996, 1992, 1998, 1998, 1993, 1995 ]

7

[]

0

null

[ "Bilateria" ]

[ 20479 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 91, 78, 51, 63 ]

4

true

Domain

Connexin, cysteine-rich domain

Connexin_CCC

1

IPR019571

19,571

Involucrin, N-terminal

Involucrin_N

Domain

175

false

Involucrin [ , ] is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an...

[]

0

[ "PFAM" ]

[ "PF10583" ]

[ "Involucrin_N" ]

[ 175 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6809371", "R-HSA-9725554" ]

[ "REACTOME:R-HSA-6809371", "REACTOME:R-HSA-9725554" ]

2

[]

0

[ "PUB00003188", "PUB00003634", "PUB00003636", "PUB00044321" ]

[ "8098344", "1359382", "8277848", "16982614" ]

[ "Involucrin--structure and role in envelope assembly.", "Consecutive actions of different gene-altering mechanisms in the evolution of involucrin.", "The involucrin genes of the mouse and the rat: study of their shared repeats.", "Apigenin inhibition of involucrin gene expression is associated with a specific...

[ 1993, 1992, 1993, 2006 ]

4

[]

0

null

[ "Eutheria" ]

[ 175 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 3 ]

3

true

Domain

Involucrin, N-terminal

Involucrin_N

9

IPR019574

19,574

NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding

NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd

Domain

30,620

false

This entry represents the iron-sulphur binding domain of the G subunit. This domain consists of just two α-helices separated by a loop region that coordinates a [4Fe-4S] cluster through an unusual H-x(3)-C-x(2)-C-x(5)-C motif that includes one His and three Cys residues [ , , ]. This domain is found in the G subunit (o...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF10588", "PS51839", "SM00929" ]

[ "NADH-G_4Fe-4S_3", "4FE4S_HC3", "NADH-G_4Fe-4S_3" ]

[ 30227, 30386, 30371 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.1.1", "R-BTA-611105", "R-BTA-6799198", "R-BTA-9837999", "R-DDI-6799198", "R-DDI-9837999", "R-DME-611105", "R-DME-6799198", "R-DME-9837999", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-MMU-611105", "R-MMU-6799198", "R-MMU-9837999", "R-RNO-611105", "R-RNO-6799198", "R-RNO...

[ "EC:7.1.1", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-9837999", "REACTOME:R-DDI-6799198", "REACTOME:R-DDI-9837999", "REACTOME:R-DME-611105", "REACTOME:R-DME-6799198", "REACTOME:R-DME-9837999", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9837999",...

18

[ "1c4a", "1c4c", "1feh", "2fug", "2ybb", "3c8y", "3i9v", "3iam", "3ias", "3m9s", "4hea", "4xdc", "4xdd", "5byq", "5byr", "5bys", "5gpn", "5gup", "5la3", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5oef", "5xf9", "5xfa", "5xtb", "5xtd", "5xth", "5xti", "6g2j"...

369

[ "PUB00005074", "PUB00043561", "PUB00045437", "PUB00053330", "PUB00087088", "PUB00087089", "PUB00155460" ]

[ "1470679", "10940377", "18394423", "9756865", "10694885", "18603533", "6822536" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I).", "Structural analysis of th...

[ 1992, 2000, 2008, 1998, 2000, 2008, 1983 ]

7

[]

[ "IPR055150" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 281, 24752, 4962, 625 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 7, 1, 1, 4, 1, 5, 3, 1, 2, 3, 8 ]

11

true

Domain

NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding

NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd

4

IPR019575

19,575

NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain

Nuop51_4Fe4S-bd

Domain

32,455

false

This entry represents the iron-sulphur binding domain of NADH-ubiquinone oxidoreductase 51kDa subunit from NADH:ubiquinone oxidoreductase. Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 51kDa (in mammals), which is the second largest subunit of complex I [ ]. The 51k...

[ "GO:0051539" ]

[ "4 iron, 4 sulfur cluster binding" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF10589", "SM00928" ]

[ "NADH_4Fe-4S", "NADH_4Fe-4S" ]

[ 32430, 31514 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.1.1", "R-DDI-6799198", "R-DDI-9837999", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-MMU-611105", "R-MMU-6799198", "R-MMU-9837999", "R-SPO-9837999" ]

[ "EC:7.1.1", "REACTOME:R-DDI-6799198", "REACTOME:R-DDI-9837999", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198", "REACTOME:R-MMU-9837999", "REACTOME:R-SPO-9837999" ]

10

[ "2fug", "2ybb", "3i9v", "3iam", "3ias", "3m9s", "4hea", "4wz7", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xf9", "5xfa", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6h8k", "6hl2", "6hl3", "6hl4", "6hla", "6hli", "6hlj", "6hlm"...

381

[ "PUB00001392", "PUB00005074", "PUB00040815", "PUB00043561", "PUB00045437", "PUB00071848" ]

[ "2029890", "1470679", "16469879", "10940377", "18394423", "12600193" ]

[ "The respiratory-chain NADH dehydrogenase (complex I) of mitochondria.", "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.", "The respiratory complex I of bacteria, archaea and eukarya and its modul...

[ 1991, 1992, 2006, 2000, 2008, 2003 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 269, 26480, 4838, 868 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 2, 1, 1, 7, 1, 7, 3, 1, 4, 4, 1, 10 ]

12

true

Domain

NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain

Nuop51_4Fe4S-bd

5

IPR019576

19,576

Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal

Pyridoxamine_oxidase_dimer_C

Domain

22,332

false

Pyridoxamine 5'-phosphate oxidase ( ) is an enzyme that is involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. It oxidizes pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P. The enzyme requires the presence of flavin mononucleotide (FMN) as a cofactor, although there is ...

[]

0

[ "PFAM" ]

[ "PF10590" ]

[ "PNP_phzG_C" ]

[ 22332 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.4.3.5", "PWY-7204", "PWY-7282", "R-BTA-964975", "R-CEL-964975", "R-DDI-964975", "R-HSA-964975", "R-MMU-964975", "R-RNO-964975", "R-SCE-964975", "R-SPO-964975" ]

[ "EC:1.4.3.5", "METACYC:PWY-7204", "METACYC:PWY-7282", "REACTOME:R-BTA-964975", "REACTOME:R-CEL-964975", "REACTOME:R-DDI-964975", "REACTOME:R-HSA-964975", "REACTOME:R-MMU-964975", "REACTOME:R-RNO-964975", "REACTOME:R-SCE-964975", "REACTOME:R-SPO-964975" ]

11

[ "1ci0", "1dnl", "1g76", "1g77", "1g78", "1g79", "1jnw", "1nrg", "1t9m", "1ty9", "1wv4", "2a2j", "3hy8", "4hms", "4hmt", "4hmu", "4hmv", "4hmw", "4hmx", "6h00", "6ylz", "6ymh", "8qyt", "8qyw", "8ros" ]

25

[ "PUB00001735", "PUB00002199", "PUB00002264", "PUB00024258", "PUB00055044", "PUB00081964", "PUB00155385" ]

[ "8586283", "1356963", "7896706", "10903950", "20675471", "26327315", "23897464" ]

[ "Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium. Pseudomonas aureofaciens 30-84.", "Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations.", "Sterol uptake induced by an impairment ...

[ 1995, 1992, 1995, 2000, 2010, 2015, 2013 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 17655, 4350, 5, 322 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 3, 1, 1, 2, 1, 6, 1, 1, 5, 2, 1, 1, 3 ]

13

true

Domain

Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal

Pyridoxamine_oxidase_dimer_C

2

IPR019577

19,577

SPARC/Testican, calcium-binding domain

SPARC/Testican_Ca-bd-dom

Domain

10,988

false

This entry represents the calcium-binding domain found in SPARC (Secreted Protein Acidic and Rich in Cysteine) and Testican (also known as SPOCK; or SParc/Osteonectin, Cwcv and Kazal-like domains) proteins. SPARC proteins are down-regulated in various tumours and may have a tumour-suppressor function [ , ]. Testican-3 ...

[ "GO:0005509" ]

[ "calcium ion binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10591" ]

[ "SPARC_Ca_bdg" ]

[ 10988 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114608", "R-BTA-3000178", "R-BTA-3000497", "R-CEL-114608", "R-CEL-3000178", "R-CEL-381426", "R-CEL-8957275", "R-HSA-114608", "R-HSA-1251985", "R-HSA-1592389", "R-HSA-3000178", "R-HSA-3000497", "R-HSA-381426", "R-HSA-8957275", "R-MMU-114608", "R-MMU-1592389", "R-MMU-3000178", ...

[ "REACTOME:R-BTA-114608", "REACTOME:R-BTA-3000178", "REACTOME:R-BTA-3000497", "REACTOME:R-CEL-114608", "REACTOME:R-CEL-3000178", "REACTOME:R-CEL-381426", "REACTOME:R-CEL-8957275", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-1251985", "REACTOME:R-HSA-1592389", "REACTOME:R-HSA-3000178", "REACTOME:R-...

28

[ "1bmo", "1nub", "1sra", "2v53", "7kbu" ]

5

[ "PUB00044495", "PUB00045267", "PUB00045268", "PUB00045269" ]

[ "16121393", "17325739", "18459035", "19144404" ]

[ "The C-terminal Ca2+-binding domain of SPARC confers anti-spreading activity to human urothelial cells.", "Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer.", "The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host.", "Testican 3 expre...

[ 2006, 2007, 2008, 2009 ]

4

[]

[ "IPR037640" ]

0

1

0

[ "Bacteria", "Eukaryota", "hydrocarbon metagenome" ]

[ 37, 10950, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 73, 8, 26, 30, 36 ]

6

true

Domain

SPARC/Testican, calcium-binding domain

SPARC/Testican_Ca-bd-dom

7

IPR019579

19,579

Protein FAM161A/B

FAM161A/B

Family

3,042

false

This entry includes the animal proteins FAM161A and FAM16B. Protein FAM161A is involved in ciliogenesis and associated with retinal cilipathaties [ ].

[]

0

[ "PFAM" ]

[ "PF10595" ]

[ "FAM161A_B" ]

[ 3042 ]

1

[]

0

[]

0

[ "PUB00076262" ]

[ "22940612" ]

[ "FAM161A, associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies." ]

[ 2012 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3042 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 4, 7, 10 ]

4

true

Family

Protein FAM161A/B

FAM161A/B

7

IPR019580

19,580

Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding

Prp8_U6-snRNA-bd

Domain

4,897

false

This entry represents the interacting site for U6-snRNA, which is part of U4/U6. U5 tri-snRNPs complex of the spliceosome is a prime candidate for the role of cofactor in the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that partici...

[ "GO:0017070" ]

[ "U6 snRNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10596" ]

[ "U6-snRNA_bdg" ]

[ 4897 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-72163", "R-CEL-72165", "R-DDI-72163", "R-HSA-72163", "R-HSA-72165", "R-MMU-72163", "R-MMU-72165", "R-SPO-72163" ]

[ "REACTOME:R-CEL-72163", "REACTOME:R-CEL-72165", "REACTOME:R-DDI-72163", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72165", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72165", "REACTOME:R-SPO-72163" ]

8

[ "3jb9", "3jcm", "3jcr", "3zef", "4i43", "5gan", "5gap", "5gm6", "5gmk", "5lj3", "5lj5", "5lqw", "5mps", "5mq0", "5mqf", "5nrl", "5o9z", "5wsg", "5xjc", "5y88", "5ylz", "5yzg", "5z56", "5z57", "5z58", "5zwm", "5zwo", "6ah0", "6ahd", "6bk8", "6exn", "6ff4"...

103

[ "PUB00044474" ]

[ "16431982" ]

[ "Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4897 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 1, 2, 8, 1, 1, 7, 3, 1, 1, 26 ]

12

true

Domain

Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding

Prp8_U6-snRNA-bd

4

IPR019581

19,581

Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding

Prp8_U5-snRNA-bd

Domain

4,836

false

The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [ ]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhap...

[ "GO:0030623" ]

[ "U5 snRNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10597" ]

[ "U5_2-snRNA_bdg" ]

[ 4836 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-72163", "R-CEL-72165", "R-DDI-72163", "R-HSA-72163", "R-HSA-72165", "R-MMU-72163", "R-MMU-72165", "R-SPO-72163" ]

[ "REACTOME:R-CEL-72163", "REACTOME:R-CEL-72165", "REACTOME:R-DDI-72163", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72165", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72165", "REACTOME:R-SPO-72163" ]

8

[ "3jb9", "3jcm", "3jcr", "3zef", "4i43", "5gan", "5gap", "5gm6", "5gmk", "5lj3", "5lj5", "5lqw", "5mps", "5mq0", "5mqf", "5nrl", "5o9z", "5wsg", "5xjc", "5y88", "5ylz", "5yzg", "5z56", "5z57", "5z58", "5zwm", "5zwo", "6ah0", "6ahd", "6bk8", "6exn", "6ff4"...

103

[ "PUB00044474" ]

[ "16431982" ]

[ "Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4836 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 1, 2, 5, 1, 1, 7, 3, 1, 1, 27 ]

12

true

Domain

Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding

Prp8_U5-snRNA-bd

3

IPR019582

19,582

RNA recognition motif, spliceosomal PrP8

RRM_spliceosomal_PrP8

Domain

4,799

false

The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is the pre-mRNA-processing-splicing factor 8 (PrP8) which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that o...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10598" ]

[ "RRM_4" ]

[ 4799 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-72163", "R-CEL-72165", "R-DDI-72163", "R-HSA-72163", "R-HSA-72165", "R-MMU-72163", "R-MMU-72165", "R-SPO-72163" ]

[ "REACTOME:R-CEL-72163", "REACTOME:R-CEL-72165", "REACTOME:R-DDI-72163", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72165", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72165", "REACTOME:R-SPO-72163" ]

8

[ "3jb9", "3jcm", "3jcr", "3zef", "4i43", "5gan", "5gap", "5gm6", "5gmk", "5lj3", "5lj5", "5lqw", "5mps", "5mq0", "5mqf", "5nrl", "5o9z", "5wsg", "5xjc", "5y88", "5ylz", "5yzg", "5z56", "5z57", "5z58", "5zwm", "5zwo", "6ah0", "6ahd", "6bk8", "6exn", "6ff4"...

103

[ "PUB00044473", "PUB00044474" ]

[ "15840809", "16431982" ]

[ "Prp8 protein: at the heart of the spliceosome.", "Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome." ]

[ 2005, 2006 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4799 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 1, 2, 5, 3, 1, 4, 3, 1, 1, 25 ]

12

true

Domain

RNA recognition motif, spliceosomal PrP8

RRM_spliceosomal_PrP8

9

IPR019583

19,583

Disks large homolog 1-4, PDZ-associated domain

DLG1-4_PDZ_assoc

Domain

10,138

false

This domain is found between the second and third PDZ domains ( ) of Disks large homolog 1-4 (DLG1-4) and similar sequences from vertebrates. Members of this group are involved in synaptic plasticity associated with NMDA receptor signalling [ ].

[]

0

[ "PFAM" ]

[ "PF10600" ]

[ "PDZ_assoc" ]

[ 10138 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CFA-399719", "R-CFA-438066", "R-CFA-451308", "R-CFA-5673001", "R-CFA-8849932", "R-DRE-438066", "R-DRE-8849932", "R-HSA-1236394", "R-HSA-399719", "R-HSA-438066", "R-HSA-442982", "R-HSA-447038", "R-HSA-451308", "R-HSA-5625900", "R-HSA-5673001", "R-HSA-5682910", "R-HSA-6794361", "R...

[ "REACTOME:R-CFA-399719", "REACTOME:R-CFA-438066", "REACTOME:R-CFA-451308", "REACTOME:R-CFA-5673001", "REACTOME:R-CFA-8849932", "REACTOME:R-DRE-438066", "REACTOME:R-DRE-8849932", "REACTOME:R-HSA-1236394", "REACTOME:R-HSA-399719", "REACTOME:R-HSA-438066", "REACTOME:R-HSA-442982", "REACTOME:R-HSA...

39

[ "2xkx", "8cn3" ]

2

[ "PUB00103858" ]

[ "26334723" ]

[ "Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5." ]

[ 2015 ]

1

[]

0

null

[ "Bilateria" ]

[ 10138 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 192, 62, 25, 40 ]

4

true

Domain

Disks large homolog 1-4, PDZ-associated domain

DLG1-4_PDZ_assoc

4

IPR019585

19,585

26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1

Rpn7/CSN1

Family

11,422

false

This entry includes 26S proteasome regulatory subunit Rpn7 and COP9 signalosome complex subunit 1 (Csn1) and fungal CSN11. The 26S proteasome plays a major role in ATP-dependent degradation of ubiquitinated proteins. Substrate specificity is conferred by the regulatory particle (RP), which can dissociate into stable li...

[]

0

[ "PANTHER" ]

[ "PTHR14145" ]

[ "" ]

[ 11422 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1234176", "R-CEL-1236978", "R-CEL-187577", "R-CEL-195253", "R-CEL-349425", "R-CEL-350562", "R-CEL-382556", "R-CEL-4608870", "R-CEL-4641258", "R-CEL-5632684", "R-CEL-5687128", "R-CEL-5689603", "R-CEL-5689880", "R-CEL-5696394", "R-CEL-6781823", "R-CEL-6798695", "R-CEL-68949", ...

[ "REACTOME:R-CEL-1234176", "REACTOME:R-CEL-1236978", "REACTOME:R-CEL-187577", "REACTOME:R-CEL-195253", "REACTOME:R-CEL-349425", "REACTOME:R-CEL-350562", "REACTOME:R-CEL-382556", "REACTOME:R-CEL-4608870", "REACTOME:R-CEL-4641258", "REACTOME:R-CEL-5632684", "REACTOME:R-CEL-5687128", "REACTOME:R-C...

273

[ "3jck", "3jco", "3jcp", "4cr2", "4cr3", "4cr4", "4d10", "4d18", "4lct", "4wsn", "5a5b", "5gjq", "5gjr", "5l4k", "5ln3", "5m32", "5mpb", "5mpc", "5mpd", "5mpe", "5t0c", "5t0g", "5t0h", "5t0i", "5t0j", "5vfp", "5vfq", "5vfr", "5vfs", "5vft", "5vfu", "5vgz"...

123

[ "PUB00034668", "PUB00045323", "PUB00045324" ]

[ "9741626", "15102831", "11114242" ]

[ "A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.", "Rpn7 Is required for the structural integrity of the 26 S proteasome of Saccharomyces cerevisiae.", "The subunit 1 of the COP9 signalosome suppresses gene expression ...

[ 1998, 2004, 2001 ]

3

[]

0

null

[ "Eukaryota" ]

[ 11422 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 2, 5, 3, 26, 8, 2, 6, 13, 2, 2, 13 ]

12

true

Family

26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1

Rpn7/CSN1

5

IPR019588

19,588

Metabotropic glutamate receptor, Homer-binding domain

Metabotropic_Glu_rcpt_Homer-bd

Domain

2,572

false

This entry represents the proline-rich region of metabotropic glutamate receptor proteins that bind Homer-related synaptic proteins. Metabotropic glutamate receptors function as receptors for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messeng...

[]

0

[ "PFAM", "SMART" ]

[ "PF10606", "SM01229" ]

[ "GluR_Homer-bdg", "GluR_Homer-bdg" ]

[ 2553, 2568 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-416476", "R-HSA-420499", "R-HSA-6794361", "R-HSA-9717207", "R-MMU-416476", "R-MMU-420499", "R-MMU-6794361", "R-RNO-416476", "R-RNO-420499", "R-RNO-6794361" ]

[ "REACTOME:R-HSA-416476", "REACTOME:R-HSA-420499", "REACTOME:R-HSA-6794361", "REACTOME:R-HSA-9717207", "REACTOME:R-MMU-416476", "REACTOME:R-MMU-420499", "REACTOME:R-MMU-6794361", "REACTOME:R-RNO-416476", "REACTOME:R-RNO-420499", "REACTOME:R-RNO-6794361" ]

10

[]

0

[ "PUB00044281", "PUB00044282" ]

[ "9808459", "18184796" ]

[ "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.", "Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation." ]

[ 1998, 2008 ]

2

[]

0

null

[ "Vertebrata" ]

[ 2572 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 4, 7, 9 ]

4

true

Domain

Metabotropic glutamate receptor, Homer-binding domain

Metabotropic_Glu_rcpt_Homer-bd

3

IPR019591

19,591

Mrp/NBP35 ATP-binding protein

Mrp/NBP35_ATP-bd

Family

39,528

false

This entry contains cytosolic Fe-S cluster assembling factors NBP35 and CFD1. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Nucleotide binding and hydrolysis seems to be critical for loading of Fe-S clusters onto CF...

[ "GO:0005524", "GO:0051536", "GO:0140663", "GO:0016226" ]

[ "ATP binding", "iron-sulfur cluster binding", "ATP-dependent FeS chaperone activity", "iron-sulfur cluster assembly" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "HAMAP", "PANTHER", "CDD" ]

[ "MF_02040", "PTHR23264", "cd02037" ]

[ "Mrp_NBP35", "", "Mrp_NBP35" ]

[ 37464, 9654, 39010 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6799198", "R-DME-6799198", "R-HSA-2564830", "R-HSA-6799198", "R-MMU-6799198" ]

[ "REACTOME:R-DDI-6799198", "REACTOME:R-DME-6799198", "REACTOME:R-HSA-2564830", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-6799198" ]

5

[ "2ph1", "3kb1", "3vx3", "5aun", "5auo", "5aup", "5auq", "6g2g", "6oby", "8zkc" ]

10

[ "PUB00009818", "PUB00044419", "PUB00045429", "PUB00045430", "PUB00070336", "PUB00070338", "PUB00080686" ]

[ "10198001", "15728363", "15667273", "15660135", "19114487", "18573874", "15601724" ]

[ "mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis.", "The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery.", "Nar1p, a conserved eukaryotic protein with sim...

[ 1999, 2005, 2005, 2005, 2009, 2008, 2005 ]

7

[ "IPR033756" ]

[ "IPR028600", "IPR028601", "IPR044304" ]

1

3

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 1280, 23729, 13814, 1, 704 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 9, 1, 8, 3, 1, 19, 14, 3, 7, 13, 2, 2, 29 ]

13

true

Family

Mrp/NBP35 ATP-binding protein

Mrp/NBP35_ATP-bd

6

IPR019592

19,592

Protein of unknown function DUF2469

DUF2469

Family

4,216

false

This entry represents a group of proteins often found in Actinomycetes species, clustered with signal peptidase and/or RNAse-HII.

[]

0

[ "PFAM" ]

[ "PF10611" ]

[ "DUF2469" ]

[ 4216 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Puccinia triticina (isolate 1-1 / race 1 (BBBD))", "metagenomes" ]

[ 4152, 1, 63 ]

3

[]

0

true

Family

Protein of unknown function DUF2469

DUF2469

3

IPR019593

19,593

Spore coat protein Z/Y

Spore_coat_protein_Z/Y

Family

1,289

false

This entry represents proteins spore coat proteins Z (aka CotZ) and Y (aka CotY). They belong to a cysteine-rich spore coat family and are necessary for the assembly of intact exosporium.

[]

0

[ "PFAM" ]

[ "PF10612" ]

[ "Spore-coat_CotZ" ]

[ 1289 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 1287, 2 ]

2

[]

0

true

Family

Spore coat protein Z/Y

Spore_coat_protein_Z/Y

3

IPR019594

19,594

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

Glu/Gly-bd

Domain

55,053

false

This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and binds L-glutamate and glycine in the ionotropic glutamate receptor NMDA [ , ]. It is found in association with .

[ "GO:0015276", "GO:0016020" ]

[ "ligand-gated monoatomic ion channel activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "SMART" ]

[ "PF10613", "SM00918" ]

[ "Lig_chan-Glu_bd", "Lig_chan-Glu_bd" ]

[ 54540, 42318 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-204005", "R-CEL-399710", "R-CEL-438066", "R-CEL-5694530", "R-CEL-8849932", "R-CFA-3928662", "R-CFA-438066", "R-CFA-5673001", "R-CFA-8849932", "R-CFA-9609736", "R-DME-204005", "R-DME-3928662", "R-DME-399710", "R-DME-416993", "R-DME-438066", "R-DME-5694530", "R-DME-8849932", "...

[ "REACTOME:R-CEL-204005", "REACTOME:R-CEL-399710", "REACTOME:R-CEL-438066", "REACTOME:R-CEL-5694530", "REACTOME:R-CEL-8849932", "REACTOME:R-CFA-3928662", "REACTOME:R-CFA-438066", "REACTOME:R-CFA-5673001", "REACTOME:R-CFA-8849932", "REACTOME:R-CFA-9609736", "REACTOME:R-DME-204005", "REACTOME:R-D...

63

[ "1ftj", "1ftk", "1ftl", "1ftm", "1fto", "1fw0", "1gr2", "1lb8", "1lb9", "1lbb", "1lbc", "1m5b", "1m5c", "1m5d", "1m5e", "1m5f", "1mm6", "1mm7", "1mqd", "1mqg", "1mqh", "1mqi", "1mqj", "1ms7", "1mxu", "1mxv", "1mxw", "1mxx", "1mxy", "1mxz", "1my0", "1my1"...

774

[ "PUB00044334", "PUB00044397", "PUB00072710" ]

[ "10465381", "8428958", "20808886" ]

[ "Subunit- and site-specific pharmacology of the NMDA receptor channel.", "Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.", "Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction." ]

[ 1999, 1993, 2010 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 247, 54805, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 108, 20, 236, 50, 102, 73, 45, 104, 56 ]

9

true

Domain

Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

Glu/Gly-bd

7

IPR019595

19,595

Domain of unknown function DUF2470

DUF2470

Domain

9,410

false

This entry represents an uncharacterised domain that can be found in a group of putative haem-iron utilisation proteins, such as HugZ from H. pylori and non-canonical heme oxygenase HOZ form Arabidopsis. HOZ is a dimeric β-barrel protein that binds to heme and catalyses its degradation to produce biliverdin [ ]. This d...

[]

0

[ "PFAM" ]

[ "PF10615" ]

[ "DUF2470" ]

[ 9410 ]

1

[]

0

[ "2arz", "3gas", "3swj", "4n7r", "5bnc", "5che", "5yjl", "6m09", "6m0a", "8fm6", "8gbk", "8gdw", "8gf4", "8zxq", "8zxr", "9bl1" ]

16

[ "PUB00075508", "PUB00075509", "PUB00075510", "PUB00155388" ]

[ "24753615", "22180625", "20657737", "33284325" ]

[ "Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein.", "An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts.", "Arabidopsis thaliana PGR7 encodes a conserved chloroplast protein that is necessary for eff...

[ 2014, 2011, 2010, 2020 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 5979, 3411, 20 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 23, 1, 6, 24 ]

4

true

Domain

Domain of unknown function DUF2470

DUF2470

1

IPR019596

19,596

Bacteriophage Mu, GpM, tail tube

Phage_Mu_GpM_tail_tub

Family

1,574

false

This entry is represented by Bacteriophage Mu, GpM tail tube protein. Bacteriophage Mu has an eicosahedral head and contractile tail. The tail is composed of an outer sheath and an inner tube.

[]

0

[ "PFAM" ]

[ "PF10618" ]

[ "Tail_tube" ]

[ 1574 ]

1

[]

0

[ "9khy", "9ki1", "9lj8" ]

3

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 1553, 11, 4, 6 ]

4

[]

0

true

Family

Bacteriophage Mu, GpM, tail tube

Phage_Mu_GpM_tail_tub

1

IPR019597

19,597

Energy-converting hydrogenase B, subunit P

Energy-convert_hydgase-B_suP

Family

100

false

Ehb (energy-converting hydrogenase B) is an methanogenic archaeal enzyme that functions in one of the metabolic pathways involved in methanol reduction to methane. This entry contains subunit P of Ehb.

[]

0

[ "PFAM" ]

[ "PF10622" ]

[ "Ehbp" ]

[ 100 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "bioreactor metagenome" ]

[ 99, 1 ]

2

[]

0

true

Family

Energy-converting hydrogenase B, subunit P

Energy-convert_hydgase-B_suP

4

IPR019598

19,598

Universal stress protein B

Universal_stress_protein_B

Family

1,304

false

Universal stress protein B (UspB) in Escherichia coli is a 14kDa protein which is predicted to be an integral membrane protein. Over expression of UspB results in cell death in stationary phase, and mutants of UspB are sensitive to ethanol exposure during stationary phase [ ].

[]

0

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01088", "NF003435", "PF10625" ]

[ "UspB", "PRK04960.1", "UspB" ]

[ 1014, 1273, 1304 ]

3

[]

0

[]

0

[ "PUB00044527" ]

[ "9829921" ]

[ "uspB, a new sigmaS-regulated gene in Escherichia coli which is required for stationary-phase resistance to ethanol." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria" ]

[ 1304 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Universal stress protein B

Universal_stress_protein_B

2

IPR019600

19,600

Hemin uptake protein HemP

Hemin_uptake_protein_HemP

Family

4,308

false

This entry represents bacterial proteins that are involved in the uptake of the iron source hemin [ ].

[]

0

[ "PFAM" ]

[ "PF10636" ]

[ "hemP" ]

[ 4308 ]

1

[]

0

[ "2jra", "2loj", "4ynx" ]

3

[ "PUB00044299" ]

[ "1425573" ]

[ "Hemin uptake system of Yersinia enterocolitica: similarities with other TonB-dependent systems in gram-negative bacteria." ]

[ 1992 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4284, 3, 21 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Hemin uptake protein HemP

Hemin_uptake_protein_HemP

9

IPR019601

19,601

Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain

Oxoglutarate/Fe-dep_Oase_C

Domain

3,762

false

This entry represents the C-terminal degradation domain of oxoglutarate and iron-dependent oxygenase (Ofd1), the domain being conserved from yeasts to humans. Ofd1 is a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N (the N-terminal transcription factor domain of Sr...

[ "GO:0005506", "GO:0016706", "GO:0031418" ]

[ "iron ion binding", "2-oxoglutarate-dependent dioxygenase activity", "L-ascorbic acid binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PFAM" ]

[ "PF10637" ]

[ "Ofd1_CTDD" ]

[ 3762 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "1.14.11.-", "PWY-102", "PWY-1187", "PWY-5035", "PWY-5036", "PWY-5047", "PWY-5070", "PWY-5349", "PWY-6085", "PWY-6086", "PWY-6495", "PWY-6682", "PWY-6915", "PWY-6919", "PWY-7150", "PWY-7151", "PWY-7232", "PWY-7274", "PWY-7298", "PWY-7398", "PWY-7419", "PWY-7517", "PWY-764...

[ "EC:1.14.11.-", "METACYC:PWY-102", "METACYC:PWY-1187", "METACYC:PWY-5035", "METACYC:PWY-5036", "METACYC:PWY-5047", "METACYC:PWY-5070", "METACYC:PWY-5349", "METACYC:PWY-6085", "METACYC:PWY-6086", "METACYC:PWY-6495", "METACYC:PWY-6682", "METACYC:PWY-6915", "METACYC:PWY-6919", "METACYC:PWY-...

41

[ "3kt1", "3kt4", "3kt7", "3mgu", "4nhk", "4nhl", "4nhm", "4nhx", "4nhy", "6e0t" ]

10

[ "PUB00044413", "PUB00045331", "PUB00093654" ]

[ "18418381", "19158663", "25728928" ]

[ "Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member.", "Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast.", "Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of pro...

[ 2008, 2009, 2015 ]

3

[]

0

null

[ "Eukaryota", "Methanobacteriati", "marine metagenome" ]

[ 3752, 7, 3 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 1, 3, 2, 1, 8, 1, 1 ]

9

true

Domain

Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain

Oxoglutarate/Fe-dep_Oase_C

3

IPR019602

19,602

mRNA capping enzyme catalytic subunit, RNA triphosphatase domain, virus

MCEL_TPase

Domain

171

false

mRNA-capping enzyme catalytic subunit from Vaccinia virus (MCEL, also known as mRNA-capping enzyme D1 subunit) catalyses the hydrolysis of the 5' triphosphate end of the pre-mRNA, the capping of the resulting diphosphate RNA end with GMP and the methylation of the GpppN cap [1-3]. It consists of an N-terminal RNA triph...

[ "GO:0004484", "GO:0004651" ]

[ "mRNA guanylyltransferase activity", "polynucleotide 5'-phosphatase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF10640" ]

[ "MCEL_TPase" ]

[ 171 ]

1

[ "EC", "EC", "EC", "METACYC" ]

[ "2.1.1.56", "2.7.7.50", "3.6.1.74", "PWY-7375" ]

[ "EC:2.1.1.56", "EC:2.7.7.50", "EC:3.6.1.74", "METACYC:PWY-7375" ]

4

[ "4ckb", "4ckc", "4cke", "6rfl", "6rie", "8p0j", "8p0k", "8p0n", "8rqk", "9fq6" ]

10

[ "PUB00044442", "PUB00044443", "PUB00044444", "PUB00100699" ]

[ "8227060", "8662635", "17989694", "24607143" ]

[ "Identification of the vaccinia virus mRNA guanyltransferase active site lysine.", "Domain structure of the vaccinia virus mRNA capping enzyme. Expression in Escherichia coli of a subdomain possessing the RNA 5'-triphosphatase and guanylyltransferase activities and a kinetic comparison to the full-size enzyme.", ...

[ 1993, 1996, 2007, 2014 ]

4

[]

0

null

[ "Poxviridae" ]

[ 171 ]

1

[]

0

true

Domain

mRNA capping enzyme catalytic subunit, RNA triphosphatase domain, virus

MCEL_TPase

1

IPR019603

19,603

Mitochondrial outer membrane translocase complex, subunit Tom5

Tom5

Family

1,114

false

This entry represents a short family of yeast proteins. Tom5 is one of three very small translocases of the mitochondrial outer membrane. Tom5 links mitochondrial preprotein receptors to the general import pore [ ]. Although Tom5 has allegedly been identified in vertebrates this could not be confirmed.

[]

0

[ "PFAM" ]

[ "PF10642" ]

[ "Tom5" ]

[ 1114 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5205685", "R-HSA-1268020", "R-HSA-5205685", "R-MMU-5205685" ]

[ "REACTOME:R-BTA-5205685", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-5205685", "REACTOME:R-MMU-5205685" ]

4

[ "6jnf", "6ucu", "6ucv", "7ck6", "7cp9", "7e4i", "7vby", "7vc4", "7vd2", "7vdd", "8b4i", "8hco", "8w5j", "8w5k", "8xdn", "8xkw", "8xkx", "8xky", "8xva", "9eih", "9eii", "9eij", "9etm", "9i6b", "9i7p", "9i7s", "9i7t", "9j99", "9jxv" ]

29

[ "PUB00044519" ]

[ "9217162" ]

[ "Tom5 functionally links mitochondrial preprotein receptors to the general import pore." ]

[ 1997 ]

1

[]

[ "IPR029179" ]

0

1

0

[ "Opisthokonta" ]

[ 1114 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2, 1, 1, 2, 1, 1 ]

8

true

Family

Mitochondrial outer membrane translocase complex, subunit Tom5

Tom5

5

IPR019604

19,604

Photosystem P840 reaction-centre, cytochrome c-551

Cytochrome-c551

Family

29

false

A photosynthetic reaction-centre complex is found in certain green sulphur bacteria such as Chlorobium vibrioforme, which are anaerobic photoautotrophic organisms. The primary electron donor is P840, a probable B-Chl a dimer, and the primary electron acceptor is a B-Chl monomer. On the donor side, c-type cytochromes ar...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10643", "PIRSF000009" ]

[ "Cytochrome-c551", "Cytochrome_c551" ]

[ 29, 20 ]

2

[]

0

[ "3a9f", "7uea", "7ueb", "7z6q", "8gwa" ]

5

[ "PUB00043528" ]

[ "1383218" ]

[ "A membrane-bound monoheme cytochrome c551 of a novel type is the immediate electron donor to P840 of the Chlorobium vibrioforme photosynthetic reaction center complex." ]

[ 1992 ]

1

[]

0

null

[ "Pseudomonadati" ]

[ 29 ]

1

[]

0

true

Family

Photosystem P840 reaction-centre, cytochrome c-551

Cytochrome-c551

2

IPR019605

19,605

Misato Segment II tubulin-like domain

Misato_II_tubulin-like

Domain

3,423

false

The misato protein contains three distinct, conserved domains, segments I, II and III and is involved in the regulation of mitochondrial distribution and morphology [ ]. This entry represents misato segment II. Segments I and III are common to tubulins ( ), but segment II aligns with myosin heavy chain sequences from D...

[]

0

[ "PFAM" ]

[ "PF10644" ]

[ "Misat_Tub_SegII" ]

[ 3423 ]

1

[]

0

[]

0

[ "PUB00044363", "PUB00045444" ]

[ "9144213", "17349998" ]

[ "An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs.", "Human Misato regulates mitochondrial distribution and morphology." ]

[ 1997, 2007 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3423 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 6, 2, 2, 5, 2, 1, 6, 3, 1, 1, 6 ]

11

true

Domain

Misato Segment II tubulin-like domain

Misato_II_tubulin-like

2

IPR019606

19,606

GerMN domain

GerMN

Domain

11,010

false

The GerMN domain is a region of approximately 100 residues that is found, duplicated, in the Bacillus GerM protein and is implicated in both sporulation and spore germination. It is also found in lipoprotein LpqB. The domain is present in a number of different bacterial species both alone and in association with other ...

[]

0

[ "PFAM", "SMART" ]

[ "PF10646", "SM00909" ]

[ "Germane", "Germane" ]

[ 10907, 9280 ]

2

[]

0

[ "5j7r", "6gz8", "6gzb" ]

3

[ "PUB00104902" ]

[ "20233304" ]

[ "A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "unclassified sequences" ]

[ 10793, 1, 4, 212 ]

4

[]

0

true

Domain

GerMN domain

GerMN

7

IPR019607

19,607

Putative zinc-finger domain

Putative_zinc-finger_domain

Domain

3,009

false

This domain is conserved in fungi and might be a zinc-finger domain as it contains three conserved Cs and an H in the C-x8-C-x5-C-x3-H conformation typical of a zinc-finger.

[]

0

[ "PFAM" ]

[ "PF10650" ]

[ "zf-C3H1" ]

[ 3009 ]

1

[ "REACTOME" ]

[ "R-HSA-9930044" ]

[ "REACTOME:R-HSA-9930044" ]

1

[ "6yfv", "6ygu" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3009 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Ze...

[ 8, 1, 3, 1, 3, 2, 2, 3, 1, 33 ]

10

true

Domain

Putative zinc-finger domain

Putative_zinc-finger_domain

5

IPR019608

19,608

Photosystem I P840 reaction centre protein PscD

PSI_P840_PscD

Family

25

false

Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitti...

[]

0

[ "PFAM" ]

[ "PF10657" ]

[ "RC-P840_PscD" ]

[ 25 ]

1

[]

0

[ "6m32", "7uea", "7ueb", "7z6q", "8gwa" ]

5

[ "PUB00043529", "PUB00152828" ]

[ "11687219", "33846594" ]

[ "The reaction center of green sulfur bacteria(1).", "Structural insights into photosystem II assembly." ]

[ 2001, 2021 ]

2

[]

0

null

[ "Chlorobiales" ]

[ 25 ]

1

[]

0

true

Family

Photosystem I P840 reaction centre protein PscD

PSI_P840_PscD

2

IPR019610

19,610

Iron sulphur domain-containing, mitoNEET, N-terminal

FeS-contain_mitoNEET_N

Domain

2,114

false

The CDGSH iron sulphur domain are a group of iron-sulphur (Fe-S) clusters and a unique 39 amino acid CDGSH domain [C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H].

[ "GO:0051537", "GO:0043231" ]

[ "2 iron, 2 sulfur cluster binding", "intracellular membrane-bounded organelle" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF10660" ]

[ "MitoNEET_N" ]

[ 2114 ]

1

[]

0

[]

0

[ "PUB00035840", "PUB00042908", "PUB00044559" ]

[ "17376863", "17766440", "17584744" ]

[ "MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.", "MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone.", "The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster." ]

[ 2007, 2007, 2007 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2114 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 5, 3, 9 ]

5

true

Domain

Iron sulphur domain-containing, mitoNEET, N-terminal

FeS-contain_mitoNEET_N

7

IPR019612

19,612

Minor capsid protein, putative

Minor_capsid_put

Family

509

false

This entry represents a putative minor capsid (or tail-knob) protein from a number of bacteriophages.

[]

0

[ "PFAM" ]

[ "PF10665" ]

[ "Minor_capsid_1" ]

[ 509 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 451, 58 ]

2

[]

0

true

Family

Minor capsid protein, putative

Minor_capsid_put

8

IPR019613

19,613

Protein of unknown function DUF4198

DUF4198

Family

6,467

false

This family, which includes Haemophilus influenzae protein HI_1624, is functionally uncharacterised. Some family members were previously annotated as prokaryotic transmembrane nickel uptake transporters, NikM. This has been shown to be incorrect, as the proteins matched do not exhibit transmembrane properties, nor do t...

[]

0

[ "PFAM" ]

[ "PF10670" ]

[ "DUF4198" ]

[ 6467 ]

1

[]

0

[ "9gcb" ]

1

[ "PUB00035607" ]

[ "16352848" ]

[ "Comparative and functional genomic analysis of prokaryotic nickel and cobalt uptake transporters: evidence for a novel group of ATP-binding cassette transporters." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 66, 6332, 7, 62 ]

4

[]

0

true

Family

Protein of unknown function DUF4198

DUF4198

3

IPR019614

19,614

S-adenosylmethionine-dependent methyltransferase

SAM-dep_methyl-trfase

Domain

25,031

false

Members of this entry are S-adenosylmethionine-dependent methyltransferases from gammaproteobacterial species. The diversity in the roles of methylation is matched by the almost bewildering number of methyltransferase enzymes that catalyse the methylation reaction. Although several classes of methyltransferase enzymes ...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10672" ]

[ "Methyltrans_SAM" ]

[ 25031 ]

1

[ "EC", "EC", "EC" ]

[ "2.1.1", "2.1.1.173", "2.1.1.264" ]

[ "EC:2.1.1", "EC:2.1.1.173", "EC:2.1.1.264" ]

3

[ "1wxw", "1wxx", "2as0", "2b78", "2cww", "2igt", "3c0k", "3ldf", "3v8v", "3v97", "3vse", "4dmg" ]

12

[ "PUB00045304" ]

[ "16545107" ]

[ "S-adenosylmethionine: jack of all trades and master of everything?" ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 76, 23844, 2, 900, 209 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 2, 3, 6 ]

4

true

Domain

S-adenosylmethionine-dependent methyltransferase

SAM-dep_methyl-trfase

3