Datasets:
LiteFold
/
InterPro

Dataset card Data Studio Files
xet
 Community
interpro_id
string
interpro_numeric_id
int64
name
string
short_name
string
entry_type
string
protein_count
int64
is_llm
bool
is_llm_reviewed
bool
abstract
string
go_ids
list
go_terms
list
go_categories
list
go_count
int64
member_databases
list
member_accessions
list
member_names
list
member_protein_counts
list
member_count
int64
external_databases
list
external_accessions
list
external_xrefs
list
external_xref_count
int64
pdb_ids
list
structure_count
int64
publication_ids
list
pubmed_ids
list
publication_titles
list
publication_years
list
publication_count
int64
parent_ids
list
child_ids
list
parent_count
int64
child_count
int64
tree_depth
float64
taxonomy_names
list
taxonomy_protein_counts
list
taxonomy_count
int64
key_species_names
list
key_species_protein_counts
list
key_species_count
int64
in_entry_list
bool
entry_list_type
string
entry_list_name
string
names_dat_name
string
short_names_dat_name
string
split_bucket
int64
IPR020280
20,280
Microcin V bacteriocin
MccV
Family
76
false
false
Members of this family are bacterial microcin-V peptides MccV, also known as colicin V. MccV was the first antibiotic substance reported to be produced by E. coli. This antibacterial agent was initially named colicin V (ColV). However, on account of several characteristics (low molecular mass, non-inducible production,...
[]
[]
[]
0
[ "PFAM" ]
[ "PF17508" ]
[ "MccV" ]
[ 76 ]
1
[]
[]
[]
0
[ "9nn6" ]
1
[ "PUB00085274" ]
[ "17653356" ]
[ "Microcins, gene-encoded antibacterial peptides from enterobacteria." ]
[ 2007 ]
1
[]
[]
0
0
null
[ "Bacteria" ]
[ 76 ]
1
[]
[]
0
true
Family
Microcin V bacteriocin
Microcin V bacteriocin
MccV
2
IPR020282
20,282
Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
Avpi1/C8orf4_dom
Domain
1,509
false
false
This entry includes arginine vasopressin-induced protein 1 (Avpi1) and C8orf4 protein. Avpi1 is thought to be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling [ ]. C8orf4, also known as transcriptional and immune response regulator (TCIM) or thyroid cancer 1 (TC-1), p...
[]
[]
[]
0
[ "PFAM" ]
[ "PF15063" ]
[ "TC1" ]
[ 1509 ]
1
[]
[]
[]
0
[]
0
[ "PUB00045971", "PUB00076422", "PUB00076423" ]
[ "12356727", "25985737", "25869879" ]
[ "A novel vasopressin-induced transcript promotes MAP kinase activation and ENaC downregulation.", "C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling.", "The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and th...
[ 2002, 2015, 2015 ]
3
[]
[]
0
0
null
[ "Vertebrata" ]
[ 1509 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 2, 3, 5 ]
4
true
Domain
Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
Avpi1/C8orf4_dom
2
IPR020285
20,285
Superinfection exclusion gene product 17
Gp17
Family
224
false
false
This protein, also known as Gp17, protects the P22 phage from the superinfection exclusion system of other prophages, such as fels-2 [ ]. Gp17 found in other bacteriophages such as SPP1 (siphophage SPP1, a lytic Bacillus subtilis phage) has been identified as a tail completion protein adopting an α/β fold, and found to...
[]
[]
[]
0
[ "PFAM" ]
[ "PF17420" ]
[ "GP17" ]
[ 224 ]
1
[]
[]
[]
0
[]
0
[ "PUB00045976", "PUB00082607" ]
[ "2738922", "22072538" ]
[ "Genetic structure of the bacteriophage P22 PL operon.", "Solution structure of gp17 from the Siphoviridae bacteriophage SPP1: insights into its role in virion assembly." ]
[ 1989, 2012 ]
2
[]
[]
0
0
null
[ "Bacteria", "Viruses", "metagenomes" ]
[ 114, 96, 14 ]
3
[]
[]
0
true
Family
Superinfection exclusion gene product 17
Superinfection exclusion gene product 17
Gp17
3
IPR020287
20,287
Tail sheath protein, C-terminal domain
Tail_sheath_C
Domain
14,033
false
false
This entry represents the C-terminal domain in a variety of phage tail sheath proteins, including Tail sheath protein from Bacteriophage T4 [ ] and Cis2 from Halogeometricum borinquense (Hbor_38820, , [ ]) [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF17482" ]
[ "Phage_sheath_1C" ]
[ 14033 ]
1
[]
[]
[]
0
[ "3hxl", "3j2m", "3j2n", "3j9q", "3j9r", "3lml", "6gkw", "6j0b", "6j0c", "6j0n", "6pyt", "6rao", "6rap", "6rbn", "6rc8", "6rgl", "6u5b", "6u5f", "6u5j", "6u5k", "7adz", "7ae0", "7aeb", "7aef", "7aek", "7b5h", "7b5i", "8bky", "8bl4", "8v3t", "8v3w", "8v3x"...
55
[ "PUB00052010", "PUB00057611", "PUB00160456" ]
[ "19229296", "22153511", "39546591" ]
[ "The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria.", "Structural conservation of the myoviridae phage tail sheath protein fold.", "Archaeal type six secretion system mediates contact-dependent antagonism." ]
[ 2009, 2011, 2024 ]
3
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]
[ 70, 12872, 41, 963, 87 ]
5
[]
[]
0
true
Domain
Tail sheath protein, C-terminal domain
Tail sheath protein, C-terminal domain
Tail_sheath_C
6
IPR020288
20,288
Contractile injection system sheath initiator
Sheath_initiator
Family
4,360
false
false
This entry represents the sheath initiator protein found in contractile injection systems like diffocins, pyocins, and phage tail-like particles. The sheath initiator acts as an intermediate between the baseplate triplex and the first layer of the sheath, and between the tube tail and hub. It has a critical role in tra...
[]
[]
[]
0
[ "PFAM" ]
[ "PF10934" ]
[ "Sheath_initiator" ]
[ 4360 ]
1
[]
[]
[]
0
[ "7kh1", "7yfz", "8env", "8eon", "8v3w", "8v41", "8v43", "9b45", "9cuy", "9euf", "9eug", "9euh", "9eui", "9euj", "9euk", "9g8s", "9gb2", "9mjn" ]
18
[ "PUB00160016" ]
[ "39152109" ]
[ "Atomic structures of a bacteriocin targeting Gram-positive bacteria." ]
[ 2024 ]
1
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]
[ 20, 3372, 10, 932, 26 ]
5
[]
[]
0
true
Family
Contractile injection system sheath initiator
Contractile injection system sheath initiator
Sheath_initiator
5
IPR020290
20,290
Gene product 88
Gp88
Domain
731
false
false
The proteins in this entry are uncharacterised, mainly found in bacteria and phage. These domains for a partial TIM-barrel fold.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17338" ]
[ "GP88" ]
[ 731 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Sphagnum jensenii", "Viruses", "metagenomes" ]
[ 16, 307, 1, 341, 66 ]
5
[]
[]
0
true
Domain
Gene product 88
Gene product 88
Gp88
4
IPR020293
20,293
Accessory recombination function protein
Arf
Family
86
false
false
Members of this family are found in Caudovirales such as Salmonella virus P22. Family members have a recombination accessory function [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF17585" ]
[ "Phage_Arf" ]
[ 86 ]
1
[]
[]
[]
0
[]
0
[ "PUB00045974", "PUB00085216" ]
[ "1827223", "25742714" ]
[ "Bacteriophage P22 accessory recombination function.", "Bacteriophage lambda: Early pioneer and still relevant." ]
[ 1991, 2015 ]
2
[]
[]
0
0
null
[ "Enterobacterales", "Lederbergvirus" ]
[ 77, 9 ]
2
[]
[]
0
true
Family
Accessory recombination function protein
Accessory recombination function protein
Arf
9
IPR020295
20,295
Protein of unknown function DUF2737
DUF2737
Family
622
false
false
The proteins in this entry are uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF10930" ]
[ "DUF2737" ]
[ 622 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Pseudomonadati", "Viruses" ]
[ 493, 129 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF2737
Protein of unknown function DUF2737
DUF2737
5
IPR020296
20,296
Sporulation protein Cse60
Spore_Cse60
Family
758
false
false
Cse60 is expressed during sporulation in Bacillus subtilis. Transcription commences around 2h after the start of sporulation and had an absolute requirement for the transcription factor sigmaE. Maximal expression of cse60 further depended on the DNA-binding protein SpoIIID. Cse60 is an acidic product of only 60 residue...
[]
[]
[]
0
[ "PFAM" ]
[ "PF10957" ]
[ "Spore_Cse60" ]
[ 758 ]
1
[]
[]
[]
0
[]
0
[ "PUB00045975" ]
[ "8990290" ]
[ "cse15, cse60, and csk22 are new members of mother-cell-specific sporulation regulons in Bacillus subtilis." ]
[ 1997 ]
1
[]
[]
0
0
null
[ "Bacteria", "Candidatus Nitrosocosmicus", "Caudoviricetes", "Pentapetalae", "metagenomes" ]
[ 726, 3, 25, 2, 2 ]
5
[]
[]
0
true
Family
Sporulation protein Cse60
Sporulation protein Cse60
Spore_Cse60
6
IPR020298
20,298
Kil protein, bacteriophage P22-type
Kil_phage_P22-type
Family
174
false
false
The bacteriophage P22 kil gene, like lambda kil, kills the host cell when it is expressed. The two kil genes, although analogous in cell killing and map location, have no sequence homology. The functions of the P22 and lambda kil genes are not known; however, P22 kil is essential for lytic growth in the absence of abc....
[]
[]
[]
0
[ "PFAM" ]
[ "PF17519" ]
[ "DUF5444" ]
[ 174 ]
1
[]
[]
[]
0
[]
0
[ "PUB00045976" ]
[ "2738922" ]
[ "Genetic structure of the bacteriophage P22 PL operon." ]
[ 1989 ]
1
[]
[]
0
0
null
[ "Enterobacterales", "Lederbergvirus" ]
[ 165, 9 ]
2
[]
[]
0
true
Family
Kil protein, bacteriophage P22-type
Kil protein, bacteriophage P22-type
Kil_phage_P22-type
6
IPR020300
20,300
Protein of unknown function DUF2644
DUF2644
Family
307
false
false
This is a family of proteins of unknown function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF10841" ]
[ "DUF2644" ]
[ 307 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Caudoviricetes", "Pseudomonadota" ]
[ 9, 298 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF2644
Protein of unknown function DUF2644
DUF2644
8
IPR020302
20,302
Uncharacterized YnfE-like
YnfE-like
Family
60
false
false
This is a family of unknown function found in Bacillus.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17452" ]
[ "YnfE" ]
[ 60 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillaceae" ]
[ 60 ]
1
[]
[]
0
true
Family
Uncharacterized YnfE-like
Uncharacterized YnfE-like
YnfE-like
6
IPR020303
20,303
Protein of unknown function DUF5495
DUF5495
Family
190
false
false
This entry represents Uncharacterized 9.8 kDa protein in Gp55-nrdG intergenic region and similar uncharacterised viral proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17599" ]
[ "DUF5495" ]
[ 190 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Viruses" ]
[ 190 ]
1
[]
[]
0
true
Family
Protein of unknown function DUF5495
Protein of unknown function DUF5495
DUF5495
5
IPR020306
20,306
Mite allergen, group 5/21
Mite_allergen_group-5/21
Family
46
false
false
This entry contains mite allergens Der p 5 [ ] and Blo t 5 [ ], belonging to the mite group 5 allergen family, Blo t 21 [ ] and Der f 21 belonging to group 21. Mite allergens causes an allergic reaction in humans [ ]. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Der p 5 bi...
[]
[]
[]
0
[ "PFAM" ]
[ "PF11642" ]
[ "Blo-t-5" ]
[ 46 ]
1
[]
[]
[]
0
[ "2jmh", "2jrk", "2lm9", "2mey", "3mq1", "5ynx", "5yny", "9had" ]
8
[ "PUB00046006", "PUB00046007", "PUB00046008", "PUB00046009" ]
[ "18520154", "18684949", "17445876", "17504089" ]
[ "Characterization of folded recombinant Der p 5, a potential diagnostic marker allergen for house dust mite allergy.", "Nuclear magnetic resonance structure and IgE epitopes of Blo t 5, a major dust mite allergen.", "Identification and characterization of a novel allergen from Blomia tropicalis: Blo t 21.", "...
[ 2008, 2008, 2007, 2007 ]
4
[]
[]
0
0
null
[ "Acariformes" ]
[ 46 ]
1
[]
[]
0
true
Family
Mite allergen, group 5/21
Mite allergen, group 5/21
Mite_allergen_group-5/21
8
IPR020308
20,308
Uncharacterised protein family, Ynq1
Uncharacterised_Ynq1
Family
607
false
false
This entry represents a group of uncharacterised proteins, such as the 9.3kDa protein YNQ1 from the nqo2 3'region in Paracoccus denitrificans. They have no known function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17272" ]
[ "DUF5337" ]
[ 607 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Pseudomonadota", "ecological metagenomes" ]
[ 603, 4 ]
2
[]
[]
0
true
Family
Uncharacterised protein family, Ynq1
Uncharacterised protein family, Ynq1
Uncharacterised_Ynq1
5
IPR020309
20,309
Small integral membrane protein 14
Smim-14
Family
1,616
false
false
This entry represents Small integral membrane protein 14 (Smim-14) proteins found in animals. The function of this protein has not been characterised. Smim-14 is predicted to act upstream of or within blastocyst hatching and to be located in the endoplasmic reticulum membrane.
[]
[]
[]
0
[ "PFAM", "PANTHER" ]
[ "PF11027", "PTHR31019" ]
[ "DUF2615", "" ]
[ 1616, 1538 ]
2
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1616 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 2, 2, 4, 4, 14 ]
6
true
Family
Small integral membrane protein 14
Small integral membrane protein 14
Smim-14
1
IPR020311
20,311
Uncharacterised protein family, Rv0898c
Uncharacterised_Rv0898c
Family
1,938
false
false
This entry contains proteins with no known function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF10944" ]
[ "DUF2630" ]
[ 1938 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "freshwater metagenome" ]
[ 1936, 2 ]
2
[]
[]
0
true
Family
Uncharacterised protein family, Rv0898c
Uncharacterised protein family, Rv0898c
Uncharacterised_Rv0898c
4
IPR020312
20,312
Protein of unknown function DUF5497
DUF5497
Family
21
false
false
This is a family of unknown function found in Alphabaculovirus. It includes the ECORI-T site protein ETS, which was identified as a 1.7-kb transcript from the coding region within the EcoRI T fragment (29.0 to 30.1 map units) in Autographa californica nuclear polyhedrosis virus (AcMNPV) [ ]. This protein is produced as...
[]
[]
[]
0
[ "PFAM" ]
[ "PF17601" ]
[ "DUF5497" ]
[ 21 ]
1
[]
[]
[]
0
[]
0
[ "PUB00052322" ]
[ "3292791" ]
[ "Characterization of an early gene accelerating expression of late genes of the baculovirus Autographa californica nuclear polyhedrosis virus." ]
[ 1988 ]
1
[]
[]
0
0
null
[ "Alphabaculovirus" ]
[ 21 ]
1
[]
[]
0
true
Family
Protein of unknown function DUF5497
Protein of unknown function DUF5497
DUF5497
4
IPR020313
20,313
Double-stranded DNA-binding protein
Double-stranded_DNA-bd
Family
342
false
false
DsbA is a double stranded binding protein found in bacteriophage T4 which is involved in transcriptional regulation. DsbA, along with other viral proteins, interacts with the host RNA polymerase core enzyme enabling initiation of transcription. DsbA acts as an enhancer protein of late genes in vitro. The protein consis...
[]
[]
[]
0
[ "PFAM" ]
[ "PF11126" ]
[ "Phage_DsbA" ]
[ 342 ]
1
[]
[]
[]
0
[]
0
[ "PUB00053255" ]
[ "9504717" ]
[ "Overexpression and structural characterization of the phage T4 protein DsbA." ]
[ 1998 ]
1
[]
[]
0
0
null
[ "Flagellimonas marina", "Viruses", "metagenomes" ]
[ 1, 338, 3 ]
3
[]
[]
0
true
Family
Double-stranded DNA-binding protein
Double-stranded DNA-binding protein
Double-stranded_DNA-bd
7
IPR020317
20,317
Uncharacterised protein family YjbD
Uncharacterised_YjbD
Family
956
false
false
This entry contains proteins with no known function.
[]
[]
[]
0
[ "NCBIFAM", "PFAM" ]
[ "NF007808", "PF11656" ]
[ "PRK10515.1", "DUF3811" ]
[ 813, 956 ]
2
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria" ]
[ 956 ]
1
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Family
Uncharacterised protein family YjbD
Uncharacterised protein family YjbD
Uncharacterised_YjbD
6
IPR020320
20,320
Swinepox virus, C2
Swinepox_virus_C2
Family
18
false
false
This entry is represented by Swinepox virus, C2; it is a family of uncharacterised viral proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17421" ]
[ "DUF5409" ]
[ 18 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Chordopoxvirinae" ]
[ 18 ]
1
[]
[]
0
true
Family
Swinepox virus, C2
Swinepox virus, C2
Swinepox_virus_C2
2
IPR020323
20,323
Protein of unknown function DUF2716
DUF2716
Family
567
false
false
This entry represents a group of uncharacterised proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF10898" ]
[ "DUF2716" ]
[ 567 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "freshwater metagenome" ]
[ 566, 1 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF2716
Protein of unknown function DUF2716
DUF2716
2
IPR020325
20,325
Uncharacterised protein family 16.1kDa
Uncharacterised_16.1kDa
Family
68
false
false
This entry contains uncharacterised proteins from the cpeY 3'-region. They have no known function, but are found in the phycobilisome.
[]
[]
[]
0
[ "PFAM" ]
[ "PF10847" ]
[ "DUF2656" ]
[ 68 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria" ]
[ 68 ]
1
[]
[]
0
true
Family
Uncharacterised protein family 16.1kDa
Uncharacterised protein family 16.1kDa
Uncharacterised_16.1kDa
6
IPR020335
20,335
Probable scaffold protein Gp13, bacteriophage T7
Phage_T7_Gp13
Family
539
false
false
Gp13 may act as an organiser for the correct association of several proteins in the surrounding of the head-tail connector protein gp8 [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF11090" ]
[ "Phage_T7_Gp13" ]
[ 539 ]
1
[]
[]
[]
0
[]
0
[ "PUB00055981" ]
[ "16054667" ]
[ "Changes in bacteriophage T7 virion structure at the initiation of infection." ]
[ 2005 ]
1
[]
[]
0
0
null
[ "Bacteria", "Viruses" ]
[ 60, 479 ]
2
[]
[]
0
true
Family
Probable scaffold protein Gp13, bacteriophage T7
Probable scaffold protein Gp13, bacteriophage T7
Phage_T7_Gp13
2
IPR020338
20,338
SMN complex, gem-associated protein 7
SMN_gemin7
Family
1,190
false
false
Gem-associated protein 7 (Gemin7) is a component of the survival of motor neuron complex, which functions in the assembly of spliceosomal small nuclear ribonucleoproteins. Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, especially SmE [ ]. Gem-associated protein 7 is found in...
[ "GO:0034719" ]
[ "SMN-Sm protein complex" ]
[ "cellular_component" ]
1
[ "PFAM", "PANTHER", "CDD" ]
[ "PF11095", "PTHR14679", "cd11677" ]
[ "Gemin7", "", "Gemin7" ]
[ 1186, 980, 562 ]
3
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-BTA-191859", "R-HSA-191859", "R-HSA-9754678", "R-MMU-191859" ]
[ "REACTOME:R-BTA-191859", "REACTOME:R-HSA-191859", "REACTOME:R-HSA-9754678", "REACTOME:R-MMU-191859" ]
4
[ "1y96", "7bbl" ]
2
[ "PUB00045980" ]
[ "12065586" ]
[ "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex." ]
[ 2002 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1190 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 2, 1, 1, 3, 7, 1 ]
6
true
Family
SMN complex, gem-associated protein 7
SMN complex, gem-associated protein 7
SMN_gemin7
7
IPR020339
20,339
Ciliary microtubule inner protein 1-like
C20orf85-like
Family
1,605
false
false
Uncharacterised protein C20orf85, also known as Ciliary microtubule inner protein 1 (CIMIP1) is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary...
[]
[]
[]
0
[ "PFAM", "PANTHER" ]
[ "PF14945", "PTHR31909" ]
[ "LLC1", "" ]
[ 1572, 1197 ]
2
[]
[]
[]
0
[ "8otz", "8snb", "9fqr" ]
3
[ "PUB00069933" ]
[ "17304513" ]
[ "Inactivation of LLC1 gene in nonsmall cell lung cancer." ]
[ 2007 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1605 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 2, 4, 6 ]
4
true
Family
Ciliary microtubule inner protein 1-like
Ciliary microtubule inner protein 1-like
C20orf85-like
4
IPR020342
20,342
Bacteriophage T4, Gp16, DNA-packaging
Phage_T4_Gp16_DNA-pack
Family
534
false
false
This entry represents the DNA-packaging protein Gp16 found in Enterobacteria phage T4 (Bacteriophage T4). Double-stranded DNA packaging in bacteriophages is driven by a molecular motor. The phage T4 motor is composed of the small terminase protein, Gpl6 (18kDa), the large terminase protein, Gp17 (70kDa), and the dodeca...
[]
[]
[]
0
[ "PFAM" ]
[ "PF11053" ]
[ "DNA_Packaging" ]
[ 534 ]
1
[]
[]
[]
0
[ "3txq", "3txs" ]
2
[ "PUB00045983", "PUB00045984", "PUB00045985" ]
[ "16513134", "18627466", "9013596" ]
[ "A critical coiled coil motif in the small terminase, gp16, from bacteriophage T4: insights into DNA packaging initiation and assembly of packaging motor.", "The headful packaging nuclease of bacteriophage T4.", "Purification and characterization of the small subunit of phage T4 terminase, gp16, required for DN...
[ 2006, 2008, 1997 ]
3
[]
[]
0
0
null
[ "Bacteroidota", "Marine Group I thaumarchaeote", "Viruses", "marine metagenome" ]
[ 2, 2, 516, 14 ]
4
[]
[]
0
true
Family
Bacteriophage T4, Gp16, DNA-packaging
Bacteriophage T4, Gp16, DNA-packaging
Phage_T4_Gp16_DNA-pack
6
IPR020343
20,343
Viral CC chemokine-like protein FPV060
Chemokine_CC_FPV060
Family
25
false
false
Members of this family found in Fowlpox virus are CC chemokine-like proteins. Fpv060 contains the conserved pattern of four cysteine residues similar to the CC chemokine family. Fpv060 also contains more cysteines in the mature protein than cellular chemokines, and one predicted trans-membrane region. In vitro studies ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF17614" ]
[ "FPV060" ]
[ 25 ]
1
[]
[]
[]
0
[]
0
[ "PUB00085211" ]
[ "15931460" ]
[ "In vitro expression and analysis of secreted fowlpox virus CC chemokine-like proteins Fpv060, Fpv061, Fpv116 and Fpv121." ]
[ 2005 ]
1
[]
[]
0
0
null
[ "Avipoxvirus" ]
[ 25 ]
1
[]
[]
0
true
Family
Viral CC chemokine-like protein FPV060
Viral CC chemokine-like protein FPV060
Chemokine_CC_FPV060
9
IPR020346
20,346
Uncharacterised protein family 15.3kDa
Uncharacterised_15.3kDa
Family
357
false
false
This entry contains proteins with no known function from the frxC 3'-region.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17265" ]
[ "DUF5331" ]
[ 357 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Cyanobacteriota" ]
[ 357 ]
1
[]
[]
0
true
Family
Uncharacterised protein family 15.3kDa
Uncharacterised protein family 15.3kDa
Uncharacterised_15.3kDa
4
IPR020347
20,347
Ribonucleases P/MRP protein subunit Pop8
Pop8
Family
1,061
false
false
Pop8 is a component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. It is also a component of Ribonuclease MRP, which cleaves pre-rRNA sequences [ ]. Ribonuclease P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7...
[ "GO:0008033", "GO:0000172", "GO:0005655" ]
[ "tRNA processing", "ribonuclease MRP complex", "nucleolar ribonuclease P complex" ]
[ "biological_process", "cellular_component", "cellular_component" ]
3
[ "PANTHER" ]
[ "PTHR28173" ]
[ "" ]
[ 1061 ]
1
[]
[]
[]
0
[ "6agb", "6ah3", "6w6v", "7c79", "7c7a" ]
5
[ "PUB00045988", "PUB00100655" ]
[ "9620854", "30262633" ]
[ "Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP.", "Structural insight into precursor tRNA processing by yeast ribonuclease P." ]
[ 1998, 2018 ]
2
[]
[]
0
0
null
[ "Opisthokonta" ]
[ 1061 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1, 1 ]
3
true
Family
Ribonucleases P/MRP protein subunit Pop8
Ribonucleases P/MRP protein subunit Pop8
Pop8
4
IPR020348
20,348
Uncharacterised protein family YvaD
Uncharacterised_YvaD
Family
391
false
false
This entry contains membrane proteins with no known function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17314" ]
[ "DUF5360" ]
[ 391 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "freshwater metagenome" ]
[ 389, 2 ]
2
[]
[]
0
true
Family
Uncharacterised protein family YvaD
Uncharacterised protein family YvaD
Uncharacterised_YvaD
4
IPR020349
20,349
Uncharacterised protein family 14.7kDa
Uncharacterised_14.7kDa
Family
599
false
false
This entry contains proteins with no known functions from the nqo3 5'region.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17267" ]
[ "DUF5333" ]
[ 599 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "marine sediment metagenome" ]
[ 597, 2 ]
2
[]
[]
0
true
Family
Uncharacterised protein family 14.7kDa
Uncharacterised protein family 14.7kDa
Uncharacterised_14.7kDa
3
IPR020350
20,350
Chemokine-like protein TAFA
Chemokine-like_TAFA
Family
5,799
false
false
This family is composed of five highly homologous small secreted proteins, TAFA1-5. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The FAM19/TAFA proteins are predominantly expressed in specific regions of the brain, a...
[]
[]
[]
0
[ "PFAM" ]
[ "PF12020" ]
[ "TAFA" ]
[ 5799 ]
1
[]
[]
[]
0
[]
0
[ "PUB00045989", "PUB00090824", "PUB00092771" ]
[ "15028294", "29453251", "30137205" ]
[ "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain.", "Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.", "Tafa-2 plays an essential role in neuronal survival and neurobiological function in mice."...
[ 2004, 2018, 2018 ]
3
[]
[ "IPR040329" ]
0
1
0
[ "Chordata" ]
[ 5799 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 26, 11, 7, 18 ]
4
true
Family
Chemokine-like protein TAFA
Chemokine-like protein TAFA
Chemokine-like_TAFA
5
IPR020351
20,351
Phage tail assemb.y chaperone protein, TAC
Phage_TAC_9
Family
119
false
false
This is a family of putative phage tail assembly chaperone proteins largely from Haemophilus and Xylella species [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF10876" ]
[ "Phage_TAC_9" ]
[ 119 ]
1
[]
[]
[]
0
[]
0
[ "PUB00075454" ]
[ "23542344" ]
[ "A conserved spiral structure for highly diverged phage tail assembly chaperones." ]
[ 2013 ]
1
[]
[]
0
0
null
[ "Caudoviricetes", "Lolium multiflorum", "Pseudomonadati", "plant metagenome" ]
[ 26, 1, 91, 1 ]
4
[]
[]
0
true
Family
Phage tail assemb.y chaperone protein, TAC
Phage tail assemb.y chaperone protein, TAC
Phage_TAC_9
3
IPR020353
20,353
mRNA interferase toxin YafO
Toxin_YafO
Family
621
false
false
YafO is a toxin which inhibits protein synthesis. It acts as a ribosome-dependent mRNA interferase. It forms part of a type II toxin-antitoxin system, where the YafN protein acts as an antitoxin [ , , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF13957" ]
[ "YafO_toxin" ]
[ 621 ]
1
[]
[]
[]
0
[]
0
[ "PUB00054169", "PUB00058200", "PUB00058201" ]
[ "19943910", "19617347", "19837801" ]
[ "Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses.", "Characterization of YafO, an Escherichia coli toxin.", "An SOS-regulated type 2 toxin-antitoxin system." ]
[ 2010, 2009, 2009 ]
3
[]
[]
0
0
null
[ "Bacteria", "Pseudomonas phage YMC11/02/R656", "hydrothermal vent metagenome" ]
[ 618, 1, 2 ]
3
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Family
mRNA interferase toxin YafO
mRNA interferase toxin YafO
Toxin_YafO
9
IPR020354
20,354
Competence, DNA-entry nuclease inhibitor, ComJ
Competence_nuclease_inhibitor
Family
501
false
false
Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use compone...
[]
[]
[]
0
[ "PFAM" ]
[ "PF11033" ]
[ "ComJ" ]
[ 501 ]
1
[]
[]
[]
0
[ "4mqd" ]
1
[ "PUB00052314", "PUB00052316" ]
[ "2841296", "8901420" ]
[ "Transformation in Bacillus subtilis: involvement of the 17-kilodalton DNA-entry nuclease and the competence-specific 18-kilodalton protein.", "Who's competent and when: regulation of natural genetic competence in bacteria." ]
[ 1988, 1996 ]
2
[]
[]
0
0
null
[ "Bacteria", "Physcomitrium patens" ]
[ 500, 1 ]
2
[]
[]
0
true
Family
Competence, DNA-entry nuclease inhibitor, ComJ
Competence, DNA-entry nuclease inhibitor, ComJ
Competence_nuclease_inhibitor
6
IPR020356
20,356
Poxvirus T3C
Poxvirus_T3C
Family
28
false
false
This entry contains proteins with no known function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF10918" ]
[ "DUF2718" ]
[ 28 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Chordopoxvirinae", "Papaver atlanticum" ]
[ 27, 1 ]
2
[]
[]
0
true
Family
Poxvirus T3C
Poxvirus T3C
Poxvirus_T3C
1
IPR020357
20,357
Transcription regulator CaiF/GrlA
Tscrpt_reg_CaiF/GrlA
Family
1,920
false
false
This is a family of transcriptional regulators that includes CaiF and GrlA. CaiF is a specific carnitine-sensitive transcription regulator [ ]. CaiF and CRP, a cyclic AMP receptor protein, are required to activate the cai and fix operons, which are involved in anaerobic carnitine metabolism [ ]. GrlA is encoded within ...
[ "GO:0006351" ]
[ "DNA-templated transcription" ]
[ "biological_process" ]
1
[ "PFAM" ]
[ "PF07180" ]
[ "CaiF_GrlA" ]
[ 1920 ]
1
[]
[]
[]
0
[ "4kt5" ]
1
[ "PUB00053440", "PUB00076312", "PUB00077941" ]
[ "10564497", "24092262", "8631699" ]
[ "Positive co-regulation of the Escherichia coli carnitine pathway cai and fix operons by CRP and the CaiF activator.", "Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes.", "Identification and characterization of the caiF gene encoding a potential transcriptional activator of carni...
[ 1999, 2013, 1996 ]
3
[]
[]
0
0
null
[ "Bacteria", "metagenomes" ]
[ 1917, 3 ]
2
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Family
Transcription regulator CaiF/GrlA
Transcription regulator CaiF/GrlA
Tscrpt_reg_CaiF/GrlA
9
IPR020359
20,359
Biofilm regulator BssR
Biofilm_regulator_BssR
Family
732
false
false
This entry represents Biofilm regulator, BssR (from the gene also known as yliH). It represses Escherichia coli biofilm formation in M9C glu and LB glu media but not in M9C and LB media. It may act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake ...
[]
[]
[]
0
[ "NCBIFAM", "PFAM" ]
[ "NF008959", "PF10799" ]
[ "PRK12302.1", "YliH" ]
[ 621, 732 ]
2
[]
[]
[]
0
[]
0
[ "PUB00044175", "PUB00053950", "PUB00075860" ]
[ "16597943", "14731270", "14727089" ]
[ "YliH (BssR) and YceP (BssS) regulate Escherichia coli K-12 biofilm formation by influencing cell signaling.", "Global impact of mature biofilm lifestyle on Escherichia coli K-12 gene expression.", "Gene expression in Escherichia coli biofilms." ]
[ 2006, 2004, 2004 ]
3
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "human gut metagenome" ]
[ 727, 3, 2 ]
3
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Family
Biofilm regulator BssR
Biofilm regulator BssR
Biofilm_regulator_BssR
3
IPR020360
20,360
Uncharacterised protein family alr2393
Uncharacterised_alr2393
Family
201
false
false
Proteins of this family are components of cyanobacterial septal junctions (microplasmodesmata) in heterocyst-forming cyanobacteria. This entry includes Uncharacterized protein alr2393.
[]
[]
[]
0
[ "NCBIFAM", "PFAM" ]
[ "NF037953", "PF17310" ]
[ "frad", "DUF5357" ]
[ 108, 201 ]
2
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria" ]
[ 201 ]
1
[]
[]
0
true
Family
Uncharacterised protein family alr2393
Uncharacterised protein family alr2393
Uncharacterised_alr2393
7
IPR020362
20,362
Tail accessory factor GP4
Tail_accessory_Gp4
Family
525
false
false
The tail complex in bacteriophage P22, and related phages, mediates host cell attachment and DNA injection. Tail assembly is a complex event that is essential for the retention and stabilisation of the newly packaged DNA within the capsid. This process involves the sequential addition of three tail accessory factors (G...
[]
[]
[]
0
[ "PFAM" ]
[ "PF11650" ]
[ "P22_Tail-4" ]
[ 525 ]
1
[]
[]
[]
0
[ "4v4k", "5gai", "5vgt", "7sfs", "7sp4", "7spu", "8eao", "8eb7", "8tvu", "8u10", "8u11", "9jg6" ]
12
[ "PUB00056238", "PUB00056239", "PUB00088229" ]
[ "21310457", "16970964", "14763988" ]
[ "Evolution of mosaically related tailed bacteriophage genomes seen through the lens of phage P22 virion assembly.", "Binding-induced stabilization and assembly of the phage P22 tail accessory factor gp4.", "Peptidoglycan hydrolytic activities associated with bacteriophage virions." ]
[ 2011, 2006, 2004 ]
3
[]
[]
0
0
null
[ "Caudoviricetes", "Eukaryota", "Pseudomonadota", "metagenomes" ]
[ 53, 2, 466, 4 ]
4
[]
[]
0
true
Family
Tail accessory factor GP4
Tail accessory factor GP4
Tail_accessory_Gp4
3
IPR020363
20,363
Uncharacterised protein family YbgS
Uncharacterised_YbgS
Family
888
false
false
This entry contains proteins with no known function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13985" ]
[ "YbgS" ]
[ 888 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Pseudomonadati", "metagenomes" ]
[ 885, 3 ]
2
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Family
Uncharacterised protein family YbgS
Uncharacterised protein family YbgS
Uncharacterised_YbgS
9
IPR020366
20,366
INO80 complex subunit Ies5
Ies5
Family
58
false
false
This entry represents the INO80 subunit 5 or Ies5, which has been shown to associate with the INO80 chromatin-remodelling complex under low-salt conditions [ ], though its function is unknown. The INO80 complex is involved in chromatin-remodelling by promoting the repositioning (sliding) or eviction of nucleosomes from...
[ "GO:0031011" ]
[ "Ino80 complex" ]
[ "cellular_component" ]
1
[ "PFAM" ]
[ "PF17335" ]
[ "IES5" ]
[ 58 ]
1
[]
[]
[]
0
[]
0
[ "PUB00052329", "PUB00052330", "PUB00052413", "PUB00052414", "PUB00052415", "PUB00052416", "PUB00052417" ]
[ "19234524", "19424290", "12887900", "19062292", "18376411", "17471029", "17721549" ]
[ "YEATS domain proteins: a diverse family with many links to chromatin modification and transcription.", "Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes.", "Involvement of actin-related proteins in ATP-dependent chromatin remodeling.", "The INO80 chromatin remodeling complex in transc...
[ 2009, 2009, 2003, 2009, 2008, 2007, 2007 ]
7
[]
[]
0
0
null
[ "Saccharomycetes" ]
[ 58 ]
1
[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]
[ 1 ]
1
true
Family
INO80 complex subunit Ies5
INO80 complex subunit Ies5
Ies5
1
IPR020367
20,367
Host transcription inhibitor Alc
Host_transcript_inhib_Alc
Family
282
false
false
Bacteriophage T4 infection rapidly shuts down transcription in the host cell and any other phages that may be present. This is accomplished by specifically blocking transcription of cytosine-containing DNA. T4 is protected from this as its DNA contains a substituted base, hydroxymethylcytosine, in place of the usual cy...
[ "GO:0039653" ]
[ "symbiont-mediated suppression of host transcription" ]
[ "biological_process" ]
1
[ "PFAM" ]
[ "PF17527" ]
[ "ALC" ]
[ 282 ]
1
[]
[]
[]
0
[]
0
[ "PUB00056236", "PUB00056237" ]
[ "6389256", "3782028" ]
[ "Identification and characterization of the alc gene product of bacteriophage T4.", "Molecular proof that bacteriophage T4 alc and unf genes are the same gene." ]
[ 1984, 1986 ]
2
[]
[]
0
0
null
[ "Viruses" ]
[ 282 ]
1
[]
[]
0
true
Family
Host transcription inhibitor Alc
Host transcription inhibitor Alc
Host_transcript_inhib_Alc
7
IPR020369
20,369
Mobilisation protein B
Mobilisation_protein_B
Family
43
false
false
Mobilization protein B (MobB) contains a putative membrane-spanning domain, and might be involved in anchoring or presenting MobA, and the covalently-linked plasmid DNA, to the conjugative pore for subsequent export. In agreement with this, MobB has been shown to be associated with the membrane. Deletion of the membran...
[]
[]
[]
0
[ "PFAM" ]
[ "PF17511" ]
[ "Mobilization_B" ]
[ 43 ]
1
[]
[]
[]
0
[]
0
[ "PUB00085271", "PUB00085272" ]
[ "19465049", "21622757" ]
[ "Replication and conjugative mobilization of broad host-range IncQ plasmids.", "Functional organization of MobB, a small protein required for efficient conjugal transfer of plasmid R1162." ]
[ 2009, 2011 ]
2
[]
[]
0
0
null
[ "Bacteria", "uncultured prokaryote" ]
[ 42, 1 ]
2
[]
[]
0
true
Family
Mobilisation protein B
Mobilisation protein B
Mobilisation_protein_B
5
IPR020372
20,372
Competence operon G protein 7, ComGG
Competence_ComGG
Family
619
false
false
This entry represents comG operon protein 7, ComGG. It is required for DNA-binding during transformation of competent bacterial cells [ ]. About half of pre-ComGG is present as a peripheral membrane protein and the other half as an integral protein. Upon partial processing, ComGG is translocated to a position outside t...
[]
[]
[]
0
[ "PFAM" ]
[ "PF14173" ]
[ "ComGG" ]
[ 619 ]
1
[]
[]
[]
0
[]
0
[ "PUB00045992", "PUB00045993", "PUB00052316", "PUB00067657" ]
[ "9422590", "9723928", "8901420", "2507524" ]
[ "All seven comG open reading frames are required for DNA binding during transformation of competent Bacillus subtilis.", "Cell surface localization and processing of the ComG proteins, required for DNA binding during transformation of Bacillus subtilis.", "Who's competent and when: regulation of natural genetic...
[ 1998, 1998, 1996, 1989 ]
4
[]
[]
0
0
null
[ "Bacillales" ]
[ 619 ]
1
[]
[]
0
true
Family
Competence operon G protein 7, ComGG
Competence operon G protein 7, ComGG
Competence_ComGG
9
IPR020376
20,376
Uncharacterised protein family F46C5.1
Uncharacterised_F46C5.1
Family
80
false
false
This entry contains membrane proteins with no known function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17351" ]
[ "DUF5380" ]
[ 80 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Rhabditina" ]
[ 80 ]
1
[ "Caenorhabditis elegans" ]
[ 2 ]
1
true
Family
Uncharacterised protein family F46C5.1
Uncharacterised protein family F46C5.1
Uncharacterised_F46C5.1
2
IPR020377
20,377
Uncharacterised protein family LpqV
Uncharacterised_LpqV
Family
335
false
false
This entry contains putative lipoproteins proteins with no known function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17301" ]
[ "LpqV" ]
[ 335 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Mycobacteriales" ]
[ 335 ]
1
[]
[]
0
true
Family
Uncharacterised protein family LpqV
Uncharacterised protein family LpqV
Uncharacterised_LpqV
8
IPR020378
20,378
Protein of unknown function DUF4186
DUF4186
Family
1,986
false
false
This protein family is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13811" ]
[ "DUF4186" ]
[ 1986 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "Pithovirus LCPAC001", "metagenomes" ]
[ 21, 1953, 2, 1, 9 ]
5
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Family
Protein of unknown function DUF4186
Protein of unknown function DUF4186
DUF4186
2
IPR020379
20,379
Protein of unknown function DUF5448
DUF5448
Family
158
false
false
This is a family of unknown function found in Gammaproteobacteria.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17526" ]
[ "DUF5448" ]
[ 158 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Enterobacterales", "Viruses" ]
[ 148, 10 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF5448
Protein of unknown function DUF5448
DUF5448
3
IPR020380
20,380
Uncharacterised protein family MJ1658
Uncharacterised_MJ1658
Family
54
false
false
This entry includes Uncharacterized protein MJ1658 and related uncharacterised proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF17393" ]
[ "DUF5402" ]
[ 54 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Methanobacteriota" ]
[ 54 ]
1
[]
[]
0
true
Family
Uncharacterised protein family MJ1658
Uncharacterised protein family MJ1658
Uncharacterised_MJ1658
3
IPR020382
20,382
Androgenic gland hormone
AGH
Family
18
false
false
This family contains members such as the androgenic gland hormone (AGH) of the woodlouse, Armadillidium vulgare. AGH is a heterodimeric glycopeptide synthesized and secreted from androgenic glands. It is responsible for sex differentiation in crustaceans and contains 4 disulfide bonds [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF17558" ]
[ "AGH" ]
[ 18 ]
1
[]
[]
[]
0
[]
0
[ "PUB00085230" ]
[ "20092253" ]
[ "Correct disulfide pairing is required for the biological activity of crustacean androgenic gland hormone (AGH): synthetic studies of AGH." ]
[ 2010 ]
1
[]
[]
0
0
null
[ "Eumalacostraca" ]
[ 18 ]
1
[]
[]
0
true
Family
Androgenic gland hormone
Androgenic gland hormone
AGH
8
IPR020383
20,383
MinK-related peptide, potassium channel accessory subunit protein 4
MPS4
Family
4
false
false
This entry represents MinK-related peptide, potassium channel accessory subunit protein 4 from Caenorhabditis elegans (MPS4) and similar proteins found in nematodes. MinK-related peptides (MiRPs or KCNEs) are single-transmembrane proteins that associate with pore-forming ion-channel sub-units to form stable complexes w...
[]
[]
[]
0
[ "PFAM" ]
[ "PF17523" ]
[ "MPS-4" ]
[ 4 ]
1
[]
[]
[]
0
[]
0
[ "PUB00085263", "PUB00085264" ]
[ "12533541", "25347290" ]
[ "A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans.", "Solution NMR of MPS-1 reveals a random coil cytosolic domain structure." ]
[ 2003, 2014 ]
2
[]
[]
0
0
null
[ "Caenorhabditis" ]
[ 4 ]
1
[ "Caenorhabditis elegans" ]
[ 1 ]
1
true
Family
MinK-related peptide, potassium channel accessory subunit protein 4
MinK-related peptide, potassium channel accessory subunit protein 4
MPS4
5
IPR020386
20,386
Uncharacterised protein family YehE
Uncharacterised_YehE
Family
622
false
false
This entry contains proteins with no known function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF10836" ]
[ "DUF2574" ]
[ 622 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Enterobacteriaceae", "Puccinia striiformis f. sp. tritici PST-78" ]
[ 621, 1 ]
2
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Family
Uncharacterised protein family YehE
Uncharacterised protein family YehE
Uncharacterised_YehE
8
IPR020387
20,387
Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf112
AcMNPV_Orf112
Family
58
false
false
This entry is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf112; it is a family of uncharacterised viral proteins. This entry also represents the N-terminal region of Fowlpox virus (FPV) FPV217. The protein family is uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF10860" ]
[ "DUF2661" ]
[ 58 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Viruses" ]
[ 58 ]
1
[]
[]
0
true
Family
Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf112
Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf112
AcMNPV_Orf112
7
IPR020390
20,390
Uncharacterised protein family YqhV
Uncharacterised_YqhV
Family
1,033
false
false
This bacterial family of proteins has no known function. This family includes the B. subtilis YqhV protein which is found just upstream of the SpoIIIA operon, suggesting it may play a role in sporulation or its regulation [1]. The protein is composed of three hydrophobic α-helices that may form transmembrane helices [ ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF10942" ]
[ "DUF2619" ]
[ 1033 ]
1
[]
[]
[]
0
[]
0
[ "PUB00034563", "PUB00152806" ]
[ "15383836", "17693505" ]
[ "The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis.", "Essential internal promoter in the spoIIIA locus of Bacillus subtilis." ]
[ 2004, 2007 ]
2
[]
[]
0
0
null
[ "Bacillota", "anaerobic digester metagenome" ]
[ 1032, 1 ]
2
[]
[]
0
true
Family
Uncharacterised protein family YqhV
Uncharacterised protein family YqhV
Uncharacterised_YqhV
8
IPR020392
20,392
Pancreatic hormone-like, conserved site
Pancreatic_hormone-like_CS
Conserved_site
2,417
false
false
This entry represents a conserved region corresponding to the C-terminal end of the active peptide. This entry represents a group of animal proteins, including Pancreatic hormone [ ], also known as Pancreatic polypeptide is a peptide (PP), which is synthesized in pancreatic islets of Langherhans and acts as a regulator...
[]
[]
[]
0
[ "PROSITE" ]
[ "PS00265" ]
[ "PANCREATIC_HORMONE_1" ]
[ 2417 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-BTA-375276", "R-BTA-418594", "R-DRE-375276", "R-DRE-418594", "R-GGA-375276", "R-GGA-418594", "R-HSA-375276", "R-HSA-418594", "R-HSA-9615017", "R-MMU-375276", "R-MMU-418594", "R-RNO-375276", "R-RNO-418594" ]
[ "REACTOME:R-BTA-375276", "REACTOME:R-BTA-418594", "REACTOME:R-DRE-375276", "REACTOME:R-DRE-418594", "REACTOME:R-GGA-375276", "REACTOME:R-GGA-418594", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-418594", "REACTOME:R-HSA-9615017", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-37...
13
[ "1bba", "1f8p", "1k8v", "1ljv", "1ppt", "1qbf", "1ron", "1ru5", "1ruu", "1tz4", "1tz5", "2bf9", "2dez", "2df0", "2h3s", "2h3t", "2h4b", "2l60", "2na5", "2oon", "2oop", "2rlk", "7rt9", "7rta", "7vgx", "7x9a", "7x9b", "7x9c", "7yon", "7yoo", "8k6m", "8k6n"...
37
[ "PUB00001432", "PUB00001581", "PUB00003973", "PUB00004503", "PUB00004504", "PUB00004595", "PUB00004634", "PUB00087297", "PUB00087298" ]
[ "1459125", "2599092", "6107857", "2067973", "1620652", "6953409", "3031687", "2070789", "20631207" ]
[ "Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine-tyrosine from the brain and gastrointestinal tract of teleost fish.", "Sheep neuropeptide Y. A third structural type of a highly conserved peptide.", "Hormone families: pancreatic hormones and homologous growth factors.", "Neu...
[ 1992, 1989, 1980, 1991, 1992, 1982, 1987, 1991, 2010 ]
9
[]
[]
0
0
null
[ "Bacteria", "Eukaryota" ]
[ 18, 2399 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 4, 4, 7, 9 ]
4
true
Conserved_site
Pancreatic hormone-like, conserved site
Pancreatic hormone-like, conserved site
Pancreatic_hormone-like_CS
5
IPR020393
20,393
Uncharacterised protein family YusU
Uncharacterised_YusU
Family
517
false
false
This entry contains proteins with no known function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF10835" ]
[ "DUF2573" ]
[ 517 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillales" ]
[ 517 ]
1
[]
[]
0
true
Family
Uncharacterised protein family YusU
Uncharacterised protein family YusU
Uncharacterised_YusU
6
IPR020394
20,394
Uncharacterised protein family, FAM23-like, transmembrane
Uncharacterised_FAM23-like_TM
Family
555
false
false
This entry represents a group of uncharacterised transmembrane proteins that are members of the FAM23 family of proteins.
[]
[]
[]
0
[ "PANTHER" ]
[ "PTHR31453" ]
[ "" ]
[ 555 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bilateria" ]
[ 555 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 5, 2, 1, 2 ]
4
true
Family
Uncharacterised protein family, FAM23-like, transmembrane
Uncharacterised protein family, FAM23-like, transmembrane
Uncharacterised_FAM23-like_TM
2
IPR020396
20,396
NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
NADH_UbQ_OxRdtase_CS
Conserved_site
28,408
false
false
Respiratory-chain NADH dehydrogenase ( ) (also known as complex I or NADH-ubiquinone oxidoreductase) is an oligomeric enzymatic complex located in the inner mitochondrial membrane which also seems to exist in the chloroplast and in cyanobacteria (as a NADH-plastoquinone oxidoreductase). Among the 25 to 30 polypeptide s...
[ "GO:0016651" ]
[ "oxidoreductase activity, acting on NAD(P)H" ]
[ "molecular_function" ]
1
[ "PROSITE" ]
[ "PS00542" ]
[ "COMPLEX1_30K" ]
[ 28408 ]
1
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "7.1.1.-", "R-DDI-6799198", "R-DDI-9013408", "R-DME-611105", "R-DME-6799198", "R-DME-9013408", "R-DME-9837999", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9013408", "R-HSA-9837999", "R-MMU-611105", "R-MMU-6799198", "R-MMU-9013408", "R-MMU-9837999" ]
[ "EC:7.1.1.-", "REACTOME:R-DDI-6799198", "REACTOME:R-DDI-9013408", "REACTOME:R-DME-611105", "REACTOME:R-DME-6799198", "REACTOME:R-DME-9013408", "REACTOME:R-DME-9837999", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9013408", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-611105...
15
[ "2fug", "2ybb", "3i9v", "3iam", "3ias", "3m9s", "4hea", "4wz7", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6h8k", "6hum", "6i0d", "6i1p", "6khi", "6khj", "6l7o", "6l7p", "6nbq", "6nbx"...
327
[ "PUB00001392", "PUB00097437" ]
[ "2029890", "27398308" ]
[ "The respiratory-chain NADH dehydrogenase (complex I) of mitochondria.", "Characterization of the Nqo5 subunit of bacterial complex I in the isolated state." ]
[ 1991, 2016 ]
2
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 755, 9417, 17922, 314 ]
4
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...
[ 9, 1, 1, 1, 1, 3, 1, 1, 7, 5, 4 ]
11
true
Conserved_site
NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site
NADH_UbQ_OxRdtase_CS
7
IPR020399
20,399
T-cell receptor-associated transmembrane adapter 1
T-cell_rcpt-assoc_TM_adapter-1
Family
536
false
false
This entry represents T-cell receptor-associated transmembrane adapter 1. It is thought to stabilise the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells [ ].
[]
[]
[]
0
[ "PANTHER" ]
[ "PTHR15951" ]
[ "" ]
[ 536 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-1257604", "R-HSA-202424", "R-HSA-2219530", "R-HSA-6811558", "R-MMU-1257604", "R-MMU-202424", "R-MMU-6811558" ]
[ "REACTOME:R-HSA-1257604", "REACTOME:R-HSA-202424", "REACTOME:R-HSA-2219530", "REACTOME:R-HSA-6811558", "REACTOME:R-MMU-1257604", "REACTOME:R-MMU-202424", "REACTOME:R-MMU-6811558" ]
7
[]
0
[ "PUB00046001" ]
[ "11390434" ]
[ "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain." ]
[ 2001 ]
1
[]
[]
0
0
null
[ "Gnathostomata" ]
[ 536 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 2, 3, 3 ]
4
true
Family
T-cell receptor-associated transmembrane adapter 1
T-cell receptor-associated transmembrane adapter 1
T-cell_rcpt-assoc_TM_adapter-1
8
IPR020400
20,400
Cecropin/Sarcotoxins/Aedesins
CecC/Srx/CECD
Family
369
false
false
This entry represents antimicrobial peptides such as Cecropins, Sarcotoxins and Aedesins from insects. Cecropins [ , , ] are potent antibacterial proteins that constitute a main part of the cell-free immunity of insects. Cecropins are small proteins of about 35 amino acid residues active against both Gram-positive and ...
[ "GO:0019731", "GO:0005576" ]
[ "antibacterial humoral response", "extracellular region" ]
[ "biological_process", "cellular_component" ]
2
[ "PANTHER" ]
[ "PTHR38329" ]
[ "" ]
[ 369 ]
1
[]
[]
[]
0
[ "2mmm" ]
1
[ "PUB00000112", "PUB00000851", "PUB00001402" ]
[ "3318666", "2015623", "1915368" ]
[ "Cell-free immunity in insects.", "Antibacterial peptides: key components needed in immunity.", "Cell-free immunity in Cecropia. A model system for antibacterial proteins." ]
[ 1987, 1991, 1991 ]
3
[ "IPR000875" ]
[]
1
0
1
[ "Endopterygota" ]
[ 369 ]
1
[ "Drosophila melanogaster" ]
[ 7 ]
1
true
Family
Cecropin/Sarcotoxins/Aedesins
Cecropin/Sarcotoxins/Aedesins
CecC/Srx/CECD
1
IPR020401
20,401
mRNA transport factor GFD1
mRNA_transport_factor_GFD1
Family
60
false
false
This entry represents the mRNA transport factor GFD1. GFD1 is a coiled-coiled protein of unknown function, which was identified as a high-copy suppressor of mutant alleles of ATP-dependent RNA helicase DBP5, which is involved in mRNA export from the nucleus. It may also play an important role in a late stage of NAB2-mR...
[]
[]
[]
0
[ "PFAM" ]
[ "PF17331" ]
[ "GFD1" ]
[ 60 ]
1
[]
[]
[]
0
[ "3lcn" ]
1
[ "PUB00046002" ]
[ "15208322" ]
[ "Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function." ]
[ 2004 ]
1
[]
[]
0
0
null
[ "Saccharomycetes" ]
[ 60 ]
1
[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]
[ 1 ]
1
true
Family
mRNA transport factor GFD1
mRNA transport factor GFD1
mRNA_transport_factor_GFD1
7
IPR020403
20,403
Equine arteritis virus envelope glycoprotein 5
EAV_Gp5
Family
454
false
false
Arteriviruses encode four envelope proteins, GL, GS, M and N. GL envelope glycoprotein is heterogenously glycosylated with N-acetyllactosamine in a cell-type-specific manner. The GL glycoprotein expresses the neutralization determinants [ ]. This entry is specific for the GL envelope glycoproteins from equine arteritis...
[]
[]
[]
0
[ "PFAM" ]
[ "PF15981" ]
[ "EAV_GP5" ]
[ 454 ]
1
[]
[]
[]
0
[]
0
[ "PUB00005612" ]
[ "8553578" ]
[ "Phylogenetic analysis of open reading frame 5 of field isolates of equine arteritis virus and identification of conserved and nonconserved regions in the GL envelope glycoprotein." ]
[ 1995 ]
1
[]
[]
0
0
null
[ "Equine arteritis virus" ]
[ 454 ]
1
[]
[]
0
true
Family
Equine arteritis virus envelope glycoprotein 5
Equine arteritis virus envelope glycoprotein 5
EAV_Gp5
4
IPR020406
20,406
Epidermin biosynthesis protein EpiC
Epidermin_biosynth_EpiC
Family
8
false
false
The LanC-like protein superfamily encompasses a highly divergent group of peptide-modifying enzymes, including the eukaryotic and bacterial lanthionine synthetase C-like proteins (LanC) [ , , ]; subtilin biosynthesis protein SpaC from Bacillus subtilis [ , ]; epidermin biosynthesis protein EpiC from Staphylococcus epid...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01954" ]
[ "EPICPROTEIN" ]
[ 8 ]
1
[]
[]
[]
0
[]
0
[ "PUB00002161", "PUB00008599", "PUB00011680", "PUB00018966", "PUB00035552", "PUB00040886", "PUB00046016", "PUB00046017", "PUB00046018", "PUB00046021", "PUB00046022", "PUB00046023", "PUB00046024", "PUB00046025", "PUB00046051" ]
[ "1735728", "1539969", "8161176", "1740156", "17347412", "16527981", "11474189", "10944443", "12566319", "1482192", "9512664", "18086512", "17894782", "8631710", "7689965" ]
[ "The subtilin gene of Bacillus subtilis ATCC 6633 is encoded in an operon that contains a homolog of the hemolysin B transport protein.", "Analysis of genes involved in biosynthesis of the lantibiotic subtilin.", "Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3.", "Analysis of genes in...
[ 1992, 1992, 1994, 1992, 2007, 2006, 2001, 2000, 2003, 1992, 1998, 2008, 2007, 1996, 1993 ]
15
[ "IPR033889" ]
[]
1
0
1
[ "Staphylococcus" ]
[ 8 ]
1
[]
[]
0
true
Family
Epidermin biosynthesis protein EpiC
Epidermin biosynthesis protein EpiC
Epidermin_biosynth_EpiC
6
IPR020408
20,408
Nerve growth factor-like
Nerve_growth_factor-like
Family
14,901
false
false
During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells [ ]. Such cells control their degree of innervation (...
[]
[]
[]
0
[ "PIRSF", "PANTHER" ]
[ "PIRSF001789", "PTHR11589" ]
[ "NGF", "" ]
[ 13723, 14901 ]
2
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-BTA-1257604", "R-BTA-6811558", "R-BTA-9026527", "R-BTA-9028731", "R-BTA-9032759", "R-BTA-9034013", "R-BTA-9034793", "R-BTA-9603381", "R-DRE-167060", "R-DRE-170984", "R-DRE-205017", "R-DRE-209543", "R-DRE-209563", "R-GGA-1257604", "R-GGA-6811558", "R-GGA-9026527", "R-GGA-9028731", ...
[ "REACTOME:R-BTA-1257604", "REACTOME:R-BTA-6811558", "REACTOME:R-BTA-9026527", "REACTOME:R-BTA-9028731", "REACTOME:R-BTA-9032759", "REACTOME:R-BTA-9034013", "REACTOME:R-BTA-9034793", "REACTOME:R-BTA-9603381", "REACTOME:R-DRE-167060", "REACTOME:R-DRE-170984", "REACTOME:R-DRE-205017", "REACTOME:R...
102
[ "1b8k", "1b8m", "1b98", "1bet", "1bnd", "1btg", "1hcf", "1nt3", "1sg1", "1sgf", "1www", "2ifg", "3buk", "3ij2", "4eax", "4ec7", "4edw", "4edx", "4efv", "4xpj", "4zbn", "5jz7", "5lsd", "6ffy", "6xuo", "6yw8", "9fik" ]
27
[ "PUB00000638", "PUB00001187", "PUB00001600", "PUB00005102", "PUB00005408", "PUB00043579", "PUB00043580" ]
[ "1477101", "2369898", "1995338", "3589669", "8488558", "2236018", "8527932" ]
[ "Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli.", "Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.", "Amino acid sequences of nerve growth factors derived from cobra venoms.", "Recruitment of enzymes as lens s...
[ 1992, 1990, 1991, 1987, 1993, 1990, 1995 ]
7
[]
[ "IPR015578", "IPR020425", "IPR020430", "IPR020431", "IPR020432" ]
0
5
0
[ "Avipoxvirus", "Bilateria" ]
[ 10, 14891 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 25, 14, 14, 24 ]
4
true
Family
Nerve growth factor-like
Nerve growth factor-like
Nerve_growth_factor-like
3
IPR020410
20,410
Interleukin-15, fish
IL-15_fish
Family
105
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-15 (IL-15) has a variety of biological functions, including stimulation and maintenance of cell...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01949" ]
[ "INTLKN15FISH" ]
[ 105 ]
1
[]
[]
[]
0
[]
0
[ "PUB00019742", "PUB00046028", "PUB00046029" ]
[ "10689297", "10784451", "17641013" ]
[ "The emerging role of IL-15 in NK-cell development.", "Control of homeostasis of CD8+ memory T cells by opposing cytokines.", "Molecular and functional characterization of IL-15 in rainbow trout Oncorhynchus mykiss: a potent inducer of IFN-gamma expression in spleen leukocytes." ]
[ 2000, 2000, 2007 ]
3
[ "IPR020439" ]
[]
1
0
1
[ "Clupeocephala" ]
[ 105 ]
1
[ "Danio rerio" ]
[ 1 ]
1
true
Family
Interleukin-15, fish
Interleukin-15, fish
IL-15_fish
5
IPR020411
20,411
Tumour necrosis factor receptor 1B
TNFR_1B
Family
551
false
false
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain- a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a...
[ "GO:0005031", "GO:0016020" ]
[ "tumor necrosis factor receptor activity", "membrane" ]
[ "molecular_function", "cellular_component" ]
2
[ "PRINTS" ]
[ "PR01919" ]
[ "TNFACTORR1B" ]
[ 551 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-5668541", "R-HSA-5669034", "R-HSA-6783783", "R-HSA-6785807", "R-HSA-6798695", "R-MMU-5668541", "R-MMU-5669034", "R-MMU-6798695", "R-RNO-5668541", "R-RNO-5669034", "R-RNO-6798695" ]
[ "REACTOME:R-HSA-5668541", "REACTOME:R-HSA-5669034", "REACTOME:R-HSA-6783783", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-5668541", "REACTOME:R-MMU-5669034", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-5668541", "REACTOME:R-RNO-5669034", "REACTOME:R-RNO-6798695" ]
11
[]
0
[ "PUB00000892", "PUB00046030", "PUB00046031", "PUB00046032", "PUB00046033", "PUB00046034", "PUB00046035" ]
[ "8387891", "7917108", "15500863", "11239407", "9826575", "9826574", "8661109" ]
[ "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.", "Tumor necrosis factor receptor superfamily members and their ligands.", "Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.", "The TNF ...
[ 1993, 1994, 2004, 2001, 1998, 1998, 1996 ]
7
[]
[]
0
0
null
[ "Amniota" ]
[ 551 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 4, 9 ]
3
true
Family
Tumour necrosis factor receptor 1B
Tumour necrosis factor receptor 1B
TNFR_1B
3
IPR020412
20,412
Interleukin-11, mammalian
IL-11_mml
Family
185
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increas...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01943" ]
[ "INTLKN11MAML" ]
[ 185 ]
1
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-6788467", "R-MMU-6788467", "R-RNO-6788467" ]
[ "REACTOME:R-HSA-6788467", "REACTOME:R-MMU-6788467", "REACTOME:R-RNO-6788467" ]
3
[ "4mhl", "6o4o", "8dps", "8dpt", "8dpu", "8dpv", "8dpw", "8qy4" ]
8
[ "PUB00013131", "PUB00046036", "PUB00046037", "PUB00046038" ]
[ "9416001", "15992047", "15720388", "16003467" ]
[ "Interleukin-11.", "The therapeutic utility of Interleukin-11 in the treatment of inflammatory disease.", "Cloning and expression of the first nonmammalian interleukin-11 gene in rainbow trout Oncorhynchus mykiss.", "Multiple and highly divergent IL-11 genes in teleost fish." ]
[ 1997, 1998, 2005, 2005 ]
4
[ "IPR020438" ]
[]
1
0
1
[ "Amniota" ]
[ 185 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 4, 5 ]
3
true
Family
Interleukin-11, mammalian
Interleukin-11, mammalian
IL-11_mml
6
IPR020413
20,413
Tumour necrosis factor receptor 9
TNFR_9
Family
186
false
false
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of ...
[ "GO:0038023", "GO:0006915", "GO:0008285", "GO:0009897" ]
[ "signaling receptor activity", "apoptotic process", "negative regulation of cell population proliferation", "external side of plasma membrane" ]
[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]
4
[ "PRINTS" ]
[ "PR01924" ]
[ "TNFACTORR9" ]
[ 186 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-5669034", "R-MMU-5669034" ]
[ "REACTOME:R-HSA-5669034", "REACTOME:R-MMU-5669034" ]
2
[]
0
[ "PUB00000892", "PUB00046030", "PUB00046031", "PUB00046032", "PUB00046033", "PUB00046034", "PUB00046039" ]
[ "8387891", "7917108", "15500863", "11239407", "9826575", "9826574", "8639902" ]
[ "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.", "Tumor necrosis factor receptor superfamily members and their ligands.", "Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.", "The TNF ...
[ 1993, 1994, 2004, 2001, 1998, 1998, 1996 ]
7
[]
[]
0
0
null
[ "Mammalia" ]
[ 186 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 3, 3 ]
3
true
Family
Tumour necrosis factor receptor 9
Tumour necrosis factor receptor 9
TNFR_9
8
IPR020415
20,415
Interleukin-34
IL-34
Family
977
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. This entry represents interleukin-34 (IL-34), it was identified via functional screening of a library of se...
[ "GO:0005157", "GO:0001934", "GO:0008284", "GO:0005615" ]
[ "macrophage colony-stimulating factor receptor binding", "positive regulation of protein phosphorylation", "positive regulation of cell population proliferation", "extracellular space" ]
[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]
4
[ "PFAM", "PRINTS", "PANTHER" ]
[ "PF15036", "PR01938", "PTHR28606" ]
[ "IL34", "INTRLEUKIN34", "" ]
[ 976, 741, 973 ]
3
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-BTA-449836", "R-HSA-449836", "R-HSA-9680350", "R-MMU-449836", "R-RNO-449836" ]
[ "REACTOME:R-BTA-449836", "REACTOME:R-HSA-449836", "REACTOME:R-HSA-9680350", "REACTOME:R-MMU-449836", "REACTOME:R-RNO-449836" ]
5
[ "4dkc", "4dkd", "4dke", "4dkf", "4exn", "4exp" ]
6
[ "PUB00046040" ]
[ "18467591" ]
[ "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome." ]
[ 2008 ]
1
[]
[]
0
0
null
[ "Gnathostomata" ]
[ 977 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 2, 1, 5 ]
4
true
Family
Interleukin-34
Interleukin-34
IL-34
2
IPR020416
20,416
Tumour necrosis factor receptor 8
TNFR_8
Family
231
false
false
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of ...
[ "GO:0004888", "GO:0007165" ]
[ "transmembrane signaling receptor activity", "signal transduction" ]
[ "molecular_function", "biological_process" ]
2
[ "PRINTS" ]
[ "PR01923" ]
[ "TNFACTORR8" ]
[ 231 ]
1
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-5669034", "R-MMU-5669034", "R-RNO-5669034" ]
[ "REACTOME:R-HSA-5669034", "REACTOME:R-MMU-5669034", "REACTOME:R-RNO-5669034" ]
3
[]
0
[ "PUB00000892", "PUB00046030", "PUB00046031", "PUB00046032", "PUB00046033", "PUB00046034", "PUB00046041", "PUB00046042" ]
[ "8387891", "7917108", "15500863", "11239407", "9826575", "9826574", "9826579", "10569134" ]
[ "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.", "Tumor necrosis factor receptor superfamily members and their ligands.", "Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.", "The TNF ...
[ 1993, 1994, 2004, 2001, 1998, 1998, 1998, 1999 ]
8
[]
[]
0
0
null
[ "Eutheria" ]
[ 231 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 2, 4 ]
3
true
Family
Tumour necrosis factor receptor 8
Tumour necrosis factor receptor 8
TNFR_8
5
IPR020419
20,419
Tumour necrosis factor receptor 1A
TNFR_1A
Family
280
false
false
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of ...
[ "GO:0005031", "GO:0006693", "GO:0006954", "GO:0033209" ]
[ "tumor necrosis factor receptor activity", "prostaglandin metabolic process", "inflammatory response", "tumor necrosis factor-mediated signaling pathway" ]
[ "molecular_function", "biological_process", "biological_process", "biological_process" ]
4
[ "PRINTS" ]
[ "PR01918" ]
[ "TNFACTORR1A" ]
[ 280 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-5357786", "R-HSA-5357905", "R-HSA-5357956", "R-HSA-5626978", "R-HSA-5669034", "R-HSA-6783783", "R-HSA-75893", "R-MMU-5357786", "R-MMU-5357905", "R-MMU-5357956", "R-MMU-5626978", "R-MMU-5669034", "R-MMU-75893", "R-RNO-5357786", "R-RNO-5357905", "R-RNO-5357956", "R-RNO-5626978",...
[ "REACTOME:R-HSA-5357786", "REACTOME:R-HSA-5357905", "REACTOME:R-HSA-5357956", "REACTOME:R-HSA-5626978", "REACTOME:R-HSA-5669034", "REACTOME:R-HSA-6783783", "REACTOME:R-HSA-75893", "REACTOME:R-MMU-5357786", "REACTOME:R-MMU-5357905", "REACTOME:R-MMU-5357956", "REACTOME:R-MMU-5626978", "REACTOME:...
19
[ "1ext", "1ft4", "1ncf", "1tnr", "7kp7", "7kp8", "7kpb", "8zui" ]
8
[ "PUB00000892", "PUB00013325", "PUB00046030", "PUB00046031", "PUB00046032", "PUB00046033", "PUB00046034" ]
[ "8387891", "12887920", "7917108", "15500863", "11239407", "9826575", "9826574" ]
[ "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.", "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.", "Tumor necrosis factor receptor superfamily members and their ligands.", "Assembly of post-re...
[ 1993, 2003, 1994, 2004, 2001, 1998, 1998 ]
7
[]
[]
0
0
null
[ "Euteleostomi" ]
[ 280 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 4, 7, 4 ]
3
true
Family
Tumour necrosis factor receptor 1A
Tumour necrosis factor receptor 1A
TNFR_1A
3
IPR020421
20,421
Interleukin-19
IL-19
Family
175
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. This entry represents interleukin-19.
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01934" ]
[ "INTRLEUKIN19" ]
[ 175 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-8854691", "R-MMU-8854691" ]
[ "REACTOME:R-HSA-8854691", "REACTOME:R-MMU-8854691" ]
2
[ "1n1f" ]
1
[ "PUB00027532", "PUB00046044" ]
[ "12403790", "11929132" ]
[ "Crystal structure of interleukin-19 defines a new subfamily of helical cytokines.", "The interleukin-10 family of cytokines." ]
[ 2003, 2002 ]
2
[ "IPR020443" ]
[]
1
0
1
[ "Boreoeutheria" ]
[ 175 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 3, 2 ]
3
true
Family
Interleukin-19
Interleukin-19
IL-19
3
IPR020422
20,422
Dual specificity protein phosphatase domain
TYR_PHOSPHATASE_DUAL_dom
Domain
88,863
false
false
Tyrosine specific protein phosphatases (PTPases) ( ) contain two conserved cysteines, the second one has been shown to be absolutely required for activity. This entry represents the PTPase domain that centre on the active site cysteine. A number of conserved residues in its immediate vicinity have also been shown to be...
[ "GO:0006470" ]
[ "protein dephosphorylation" ]
[ "biological_process" ]
1
[ "PROFILE", "SMART" ]
[ "PS50054", "SM00195" ]
[ "TYR_PHOSPHATASE_DUAL", "DSPc" ]
[ 81694, 76435 ]
2
[ "EC", "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...
[ "3.1.3", "3.1.3.48", "R-BTA-112409", "R-BTA-202670", "R-BTA-5675221", "R-CEL-112409", "R-CEL-202670", "R-CEL-5675221", "R-CEL-5687128", "R-CEL-72086", "R-CEL-77075", "R-DDI-112409", "R-DDI-202670", "R-DDI-5675221", "R-DDI-8873719", "R-DME-112409", "R-DME-202670", "R-DME-5675221", ...
[ "EC:3.1.3", "EC:3.1.3.48", "REACTOME:R-BTA-112409", "REACTOME:R-BTA-202670", "REACTOME:R-BTA-5675221", "REACTOME:R-CEL-112409", "REACTOME:R-CEL-202670", "REACTOME:R-CEL-5675221", "REACTOME:R-CEL-5687128", "REACTOME:R-CEL-72086", "REACTOME:R-CEL-77075", "REACTOME:R-DDI-112409", "REACTOME:R-DD...
54
[ "1fpz", "1fq1", "1i9s", "1i9t", "1j4x", "1m3g", "1mkp", "1ohc", "1ohd", "1ohe", "1r6h", "1rxd", "1v3a", "1vhr", "1wrm", "1x24", "1xm2", "1xri", "1yn9", "1yz4", "1zck", "1zcl", "1zzw", "2c46", "2dxp", "2e0t", "2esb", "2g6z", "2gwo", "2hcm", "2hxp", "2i6i"...
185
[ "PUB00005219", "PUB00005456", "PUB00056893", "PUB00056895", "PUB00056896", "PUB00081637", "PUB00081644", "PUB00081645", "PUB00081646", "PUB00081649" ]
[ "8650541", "8987394", "19228121", "17057753", "15186772", "7961745", "8154323", "7601801", "8701088", "9571625" ]
[ "Crystal structure of the dual specificity protein phosphatase VHR.", "Structure and function of the protein tyrosine phosphatases.", "Dual-specificity phosphatases: critical regulators with diverse cellular targets.", "Protein tyrosine phosphatases: from genes, to function, to disease.", "Protein tyrosine ...
[ 1996, 1996, 2009, 2006, 2004, 1994, 1994, 1995, 1996, 1998 ]
10
[ "IPR000387" ]
[ "IPR044506", "IPR047949", "IPR049573" ]
1
3
0
[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]
[ 301, 3100, 84895, 390, 177 ]
5
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...
[ 73, 23, 210, 30, 1, 113, 104, 7, 54, 153, 9, 4, 128 ]
13
true
Domain
Dual specificity protein phosphatase domain
Dual specificity protein phosphatase domain
TYR_PHOSPHATASE_DUAL_dom
5
IPR020423
20,423
Interleukin-10, conserved site
IL-10_CS
Conserved_site
1,444
false
false
Interleukin 10 (IL-10) is a secreted 17-21kDa protein that is non- glycosylated in humans but exists as a non-covalent homodimer. IL-10 is secreted by some types of T-lymphocyte, B-lymphocytes and macrophages late after antigen activation. Generally, IL-10 inhibits T-cell and natural killer cell synthesis of other cyto...
[]
[]
[]
0
[ "PROSITE" ]
[ "PS00520" ]
[ "INTERLEUKIN_10" ]
[ 1444 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-6783783", "R-HSA-6785807", "R-HSA-8854691", "R-HSA-8950505", "R-HSA-9609690", "R-HSA-9610379", "R-HSA-9662834", "R-HSA-9664323", "R-HSA-9725370", "R-MMU-6783783", "R-MMU-8854691", "R-RNO-6783783", "R-RNO-8854691", "R-SSC-6783783" ]
[ "REACTOME:R-HSA-6783783", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-8854691", "REACTOME:R-HSA-8950505", "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379", "REACTOME:R-HSA-9662834", "REACTOME:R-HSA-9664323", "REACTOME:R-HSA-9725370", "REACTOME:R-MMU-6783783", "REACTOME:R-MMU-8854691", "REACTOM...
14
[ "1ilk", "1inr", "1j7v", "1lk3", "1lqs", "1m4r", "1n1f", "1vlk", "1y6k", "1y6m", "1y6n", "1ykb", "2h24", "2ilk", "3dgc", "3dlq", "3g9v", "3q1s", "4doh", "4x51", "6df3", "6gg1", "6weo", "6x93", "8sve" ]
25
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Gnathostomata", "Viruses" ]
[ 1268, 176 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 18, 14, 16 ]
4
true
Conserved_site
Interleukin-10, conserved site
Interleukin-10, conserved site
IL-10_CS
8
IPR020427
20,427
Interleukin-11A, fish
IL-11A_fish
Family
202
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increas...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01945" ]
[ "IL11AFISH" ]
[ 202 ]
1
[]
[]
[]
0
[]
0
[ "PUB00013131", "PUB00046036", "PUB00046037", "PUB00046038", "PUB00046050" ]
[ "9416001", "15992047", "15720388", "16003467", "18538848" ]
[ "Interleukin-11.", "The therapeutic utility of Interleukin-11 in the treatment of inflammatory disease.", "Cloning and expression of the first nonmammalian interleukin-11 gene in rainbow trout Oncorhynchus mykiss.", "Multiple and highly divergent IL-11 genes in teleost fish.", "Teleostean IL11b exhibits com...
[ 1997, 1998, 2005, 2005, 2008 ]
5
[ "IPR022356" ]
[]
1
0
1
[ "Clupeocephala" ]
[ 202 ]
1
[ "Danio rerio" ]
[ 1 ]
1
true
Family
Interleukin-11A, fish
Interleukin-11A, fish
IL-11A_fish
4
IPR020428
20,428
Atypical dual-specificity phosphatase Siw14-like, plant and fungi
PFA-DSPs
Family
4,013
false
false
This entry represent a group of atypical dual-specificity phosphatases from plant and fungi. Proteins in this entry include Siw14 and related proteins [ ]. Siw14 is a inositol pyrophosphate phosphatase that modulates inositol pyrophosphate metabolism by dephosphorylating the IP7isoform 5PP-IP5to IP6 [ ]. This entry als...
[ "GO:0016791" ]
[ "phosphatase activity" ]
[ "molecular_function" ]
1
[ "PRINTS" ]
[ "PR01911" ]
[ "PFDSPHPHTASE" ]
[ 4013 ]
1
[]
[]
[]
0
[ "1xri", "2q47", "6byf", "6e3b", "7mod", "7moe", "7mof", "7mog", "7moh", "7moi", "7moj", "7mok", "7mol", "7mom" ]
14
[ "PUB00088170", "PUB00088172" ]
[ "26828065", "21409566" ]
[ "A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 PROTEIN SELECTIVELY CLEAVES THE β-PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP5).", "Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms." ]
[ 2016, 2011 ]
2
[ "IPR004861" ]
[]
1
0
1
[ "Eukaryota" ]
[ 4013 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]
[ 26, 9, 1, 23 ]
4
true
Family
Atypical dual-specificity phosphatase Siw14-like, plant and fungi
Atypical dual-specificity phosphatase Siw14-like, plant and fungi
PFA-DSPs
6
IPR020430
20,430
Brain-derived neurotrophic factor
Brain-der_neurotrophic_factor
Family
7,430
false
false
During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells [ ]. Such cells control their degree of innervation (...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01912" ]
[ "BDNFACTOR" ]
[ 7430 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-BTA-1257604", "R-BTA-6811558", "R-BTA-9026527", "R-BTA-9028731", "R-BTA-9032759", "R-GGA-1257604", "R-GGA-6811558", "R-GGA-9026527", "R-GGA-9028731", "R-GGA-9032759", "R-HSA-1257604", "R-HSA-2219530", "R-HSA-6811558", "R-HSA-9022702", "R-HSA-9024909", "R-HSA-9026519", "R-HSA-90265...
[ "REACTOME:R-BTA-1257604", "REACTOME:R-BTA-6811558", "REACTOME:R-BTA-9026527", "REACTOME:R-BTA-9028731", "REACTOME:R-BTA-9032759", "REACTOME:R-GGA-1257604", "REACTOME:R-GGA-6811558", "REACTOME:R-GGA-9026527", "REACTOME:R-GGA-9028731", "REACTOME:R-GGA-9032759", "REACTOME:R-HSA-1257604", "REACTOM...
38
[ "1b8m", "1bnd" ]
2
[ "PUB00000638", "PUB00001187", "PUB00001600", "PUB00046054", "PUB00046055", "PUB00046056", "PUB00046057", "PUB00046058" ]
[ "1477101", "2369898", "1995338", "7188352", "16843677", "9517463", "16632412", "17949819" ]
[ "Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli.", "Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.", "Amino acid sequences of nerve growth factors derived from cobra venoms.", "Purification of a new neurotroph...
[ 1992, 1990, 1991, 1982, 2006, 1997, 2006, 2008 ]
8
[ "IPR020408" ]
[]
1
0
1
[ "Gnathostomata" ]
[ 7430 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 8, 6, 8, 10 ]
4
true
Family
Brain-derived neurotrophic factor
Brain-derived neurotrophic factor
Brain-der_neurotrophic_factor
5
IPR020432
20,432
Neurotrophin-4
Neurotrophin-4
Family
165
false
false
During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells [ ]. Such cells control their degree of innervation (...
[ "GO:0008083", "GO:0005576" ]
[ "growth factor activity", "extracellular region" ]
[ "molecular_function", "cellular_component" ]
2
[ "PRINTS" ]
[ "PR01915" ]
[ "NEUROTROPHN4" ]
[ 165 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-1257604", "R-HSA-2219530", "R-HSA-6811558", "R-HSA-9026357", "R-HSA-9026519", "R-HSA-9026527", "R-HSA-9028335", "R-HSA-9028731", "R-MMU-1257604", "R-MMU-6811558", "R-MMU-9026527", "R-MMU-9028731", "R-RNO-1257604", "R-RNO-6811558", "R-RNO-9026527", "R-RNO-9028731" ]
[ "REACTOME:R-HSA-1257604", "REACTOME:R-HSA-2219530", "REACTOME:R-HSA-6811558", "REACTOME:R-HSA-9026357", "REACTOME:R-HSA-9026519", "REACTOME:R-HSA-9026527", "REACTOME:R-HSA-9028335", "REACTOME:R-HSA-9028731", "REACTOME:R-MMU-1257604", "REACTOME:R-MMU-6811558", "REACTOME:R-MMU-9026527", "REACTOM...
16
[]
0
[ "PUB00000638", "PUB00001187", "PUB00001600", "PUB00046059", "PUB00046060" ]
[ "1477101", "2369898", "1995338", "10869436", "18063676" ]
[ "Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli.", "Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.", "Amino acid sequences of nerve growth factors derived from cobra venoms.", "Deficient long-term memory and l...
[ 1992, 1990, 1991, 2000, 2008 ]
5
[ "IPR020408" ]
[]
1
0
1
[ "Tetrapoda" ]
[ 165 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 2, 3 ]
3
true
Family
Neurotrophin-4
Neurotrophin-4
Neurotrophin-4
7
IPR020433
20,433
Venom nerve growth factor
Venom_nerve_growth_factor
Family
485
false
false
During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells [ ]. Such cells control their degree of innervation (...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01917" ]
[ "VENOMNGF" ]
[ 485 ]
1
[]
[]
[]
0
[]
0
[ "PUB00000638", "PUB00001187", "PUB00001600", "PUB00046061", "PUB00046062", "PUB00046063" ]
[ "1477101", "2369898", "1995338", "8843580", "14529729", "11288731" ]
[ "Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli.", "Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.", "Amino acid sequences of nerve growth factors derived from cobra venoms.", "Nerve growth factors from snake ...
[ 1992, 1990, 1991, 1996, 2003, 2001 ]
6
[ "IPR020425" ]
[]
1
0
1
[ "Squamata" ]
[ 485 ]
1
[]
[]
0
true
Family
Venom nerve growth factor
Venom nerve growth factor
Venom_nerve_growth_factor
3
IPR020435
20,435
Tumour necrosis factor receptor 5
TNFR_5
Family
767
false
false
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of ...
[ "GO:0038023", "GO:0042113", "GO:0050776", "GO:0009897" ]
[ "signaling receptor activity", "B cell activation", "regulation of immune response", "external side of plasma membrane" ]
[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]
4
[ "PRINTS" ]
[ "PR01922" ]
[ "TNFACTORR5" ]
[ 767 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-BTA-198933", "R-BTA-5668541", "R-BTA-5676594", "R-HSA-198933", "R-HSA-5668541", "R-HSA-5676594", "R-MMU-198933", "R-MMU-5668541", "R-MMU-5676594", "R-SSC-198933", "R-SSC-5668541", "R-SSC-5676594" ]
[ "REACTOME:R-BTA-198933", "REACTOME:R-BTA-5668541", "REACTOME:R-BTA-5676594", "REACTOME:R-HSA-198933", "REACTOME:R-HSA-5668541", "REACTOME:R-HSA-5676594", "REACTOME:R-MMU-198933", "REACTOME:R-MMU-5668541", "REACTOME:R-MMU-5676594", "REACTOME:R-SSC-198933", "REACTOME:R-SSC-5668541", "REACTOME:R-...
12
[ "3qd6", "5dmi", "5dmj", "5ihl", "6fax", "6pe8", "6pe9", "7p3i", "8yx1", "8yx9" ]
10
[ "PUB00000892", "PUB00046030", "PUB00046031", "PUB00046032", "PUB00046033", "PUB00046034", "PUB00046066" ]
[ "8387891", "7917108", "15500863", "11239407", "9826575", "9826574", "10647992" ]
[ "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.", "Tumor necrosis factor receptor superfamily members and their ligands.", "Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.", "The TNF ...
[ 1993, 1994, 2004, 2001, 1998, 1998, 2000 ]
7
[]
[]
0
0
null
[ "Gnathostomata" ]
[ 767 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 9, 1, 10 ]
3
true
Family
Tumour necrosis factor receptor 5
Tumour necrosis factor receptor 5
TNFR_5
6
IPR020436
20,436
Somatomedin B domain, chordata
SMB_chordata
Domain
5,094
false
false
This entry includes chordates proteins. Somatomedin B (SMB), a serum factor of unknown function, is a small cysteine-rich peptide, derived proteolytically from the N terminus of the cell-substrate adhesion protein vitronectin [ ]. Cys-rich somatomedin B-like domains are found in a number of proteins [ ], including ecto...
[ "GO:0005044", "GO:0030247", "GO:0006955" ]
[ "scavenger receptor activity", "polysaccharide binding", "immune response" ]
[ "molecular_function", "molecular_function", "biological_process" ]
3
[ "PRINTS" ]
[ "PR00022" ]
[ "SOMATOMEDINB" ]
[ 5094 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-196843", "R-HSA-199220", "R-HSA-2129379", "R-HSA-216083", "R-HSA-3000170", "R-HSA-3000178", "R-HSA-977606", "R-HSA-9925563", "R-MMU-196843", "R-MMU-2129379", "R-MMU-216083", "R-MMU-3000170", "R-MMU-3000178", "R-MMU-977606", "R-RNO-196843", "R-SSC-2129379", "R-SSC-216083", "R...
[ "REACTOME:R-HSA-196843", "REACTOME:R-HSA-199220", "REACTOME:R-HSA-2129379", "REACTOME:R-HSA-216083", "REACTOME:R-HSA-3000170", "REACTOME:R-HSA-3000178", "REACTOME:R-HSA-977606", "REACTOME:R-HSA-9925563", "REACTOME:R-MMU-196843", "REACTOME:R-MMU-2129379", "REACTOME:R-MMU-216083", "REACTOME:R-MM...
20
[ "1oc0", "1s4g", "1ssu", "2jq8", "2xr9", "2xrg", "3bt1", "3bt2", "3nkm", "3nkn", "3nko", "3nkp", "3nkq", "3nkr", "3wav", "3waw", "3wax", "3way", "4gtw", "4gtx", "4gty", "4gtz", "4k24", "4zg6", "4zg9", "4zga", "5dlt", "5dlv", "5dlw", "5hrt", "5ijq", "5ijs"...
271
[ "PUB00000196", "PUB00000290", "PUB00004746", "PUB00015354", "PUB00015355", "PUB00015356" ]
[ "1710108", "2447940", "1647027", "12533192", "15157085", "12808446" ]
[ "Homology of placental protein 11 and pea seed albumin 2 with vitronectin.", "Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the \"pexin\" family and a model for their evolution.", "Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity ...
[ 1991, 1987, 1991, 2003, 2004, 2003 ]
6
[ "IPR001212" ]
[]
1
0
1
[ "Eukaryota" ]
[ 5094 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 22, 16, 14, 29 ]
4
true
Domain
Somatomedin B domain, chordata
Somatomedin B domain, chordata
SMB_chordata
7
IPR020437
20,437
Nerve growth factor, beta subunit, mammalian
Nerve_growth_factor_bsu_mml
Family
225
false
false
During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells [ ]. Such cells control their degree of innervation (...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01925" ]
[ "MAMLNGFBETA" ]
[ 225 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-HSA-167021", "R-HSA-167044", "R-HSA-167060", "R-HSA-170968", "R-HSA-170984", "R-HSA-177504", "R-HSA-187042", "R-HSA-187706", "R-HSA-193648", "R-HSA-193670", "R-HSA-193681", "R-HSA-198203", "R-HSA-198745", "R-HSA-205017", "R-HSA-205025", "R-HSA-205043", "R-HSA-209543", "R-HSA-209...
[ "REACTOME:R-HSA-167021", "REACTOME:R-HSA-167044", "REACTOME:R-HSA-167060", "REACTOME:R-HSA-170968", "REACTOME:R-HSA-170984", "REACTOME:R-HSA-177504", "REACTOME:R-HSA-187042", "REACTOME:R-HSA-187706", "REACTOME:R-HSA-193648", "REACTOME:R-HSA-193670", "REACTOME:R-HSA-193681", "REACTOME:R-HSA-198...
43
[ "3ij2", "6xuo" ]
2
[ "PUB00000638", "PUB00001187", "PUB00001600", "PUB00046045", "PUB00046046", "PUB00046047", "PUB00046062", "PUB00046067" ]
[ "1477101", "2369898", "1995338", "1055377", "11437236", "15260993", "14529729", "14976160" ]
[ "Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli.", "Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.", "Amino acid sequences of nerve growth factors derived from cobra venoms.", "Crystallization of nerve growth ...
[ 1992, 1990, 1991, 1975, 2001, 2004, 2003, 2004 ]
8
[ "IPR020425" ]
[]
1
0
1
[ "Eutheria" ]
[ 225 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 3, 6 ]
3
true
Family
Nerve growth factor, beta subunit, mammalian
Nerve growth factor, beta subunit, mammalian
Nerve_growth_factor_bsu_mml
8
IPR020438
20,438
Interleukin-11
IL-11
Family
695
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increas...
[]
[]
[]
0
[ "PFAM", "PRINTS", "PANTHER" ]
[ "PF07400", "PR01927", "PTHR16922" ]
[ "IL11", "INTRLEUKIN11", "" ]
[ 695, 413, 664 ]
3
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-6788467", "R-MMU-6788467", "R-RNO-6788467" ]
[ "REACTOME:R-HSA-6788467", "REACTOME:R-MMU-6788467", "REACTOME:R-RNO-6788467" ]
3
[ "4mhl", "6o4o", "8dps", "8dpt", "8dpu", "8dpv", "8dpw", "8qy4" ]
8
[ "PUB00013131", "PUB00046036" ]
[ "9416001", "15992047" ]
[ "Interleukin-11.", "The therapeutic utility of Interleukin-11 in the treatment of inflammatory disease." ]
[ 1997, 1998 ]
2
[]
[ "IPR020412", "IPR022356" ]
0
2
0
[ "Gnathostomata" ]
[ 695 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 3, 4, 5 ]
4
true
Family
Interleukin-11
Interleukin-11
IL-11
6
IPR020439
20,439
Interleukin-15
IL-15
Family
928
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-15 (IL-15) has a variety of biological functions, including stimulation and maintenance of cell...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01930" ]
[ "INTRLEUKIN15" ]
[ 928 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-BTA-8983432", "R-HSA-8983432", "R-MMU-8983432", "R-RNO-8983432" ]
[ "REACTOME:R-BTA-8983432", "REACTOME:R-HSA-8983432", "REACTOME:R-MMU-8983432", "REACTOME:R-RNO-8983432" ]
4
[ "2psm", "2xqb", "2z3q", "2z3r", "4gs7" ]
5
[ "PUB00019742", "PUB00046028" ]
[ "10689297", "10784451" ]
[ "The emerging role of IL-15 in NK-cell development.", "Control of homeostasis of CD8+ memory T cells by opposing cytokines." ]
[ 2000, 2000 ]
2
[ "IPR003443" ]
[ "IPR020410", "IPR020451", "IPR020466" ]
1
3
0
[ "Gnathostomata" ]
[ 928 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 1, 3, 3 ]
4
true
Family
Interleukin-15
Interleukin-15
IL-15
2
IPR020440
20,440
Interleukin-17, chordata
IL-17_chr
Family
3,840
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-17 (IL-17) is a potent proinflammatory cytokine produced by activated memory T cells [ ]. The I...
[ "GO:0005125", "GO:0006954", "GO:0005576" ]
[ "cytokine activity", "inflammatory response", "extracellular region" ]
[ "molecular_function", "biological_process", "cellular_component" ]
3
[ "PRINTS" ]
[ "PR01932" ]
[ "INTRLEUKIN17" ]
[ 3840 ]
1
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-448424", "R-HSA-6785807", "R-HSA-9705671" ]
[ "REACTOME:R-HSA-448424", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-9705671" ]
3
[ "1jpy", "2vxs", "3jvf", "4hr9", "4hsa", "4qhu", "5hhv", "5hhx", "5hi3", "5hi4", "5hi5", "5n7w", "5n92", "5nan", "5vb9", "6hg4", "6hg9", "6hgo", "6ppg", "6wio", "6wir", "7ama", "7amg", "7uwm", "7uwn", "7wkx", "7z2m", "7zan", "8b7w", "8cdg", "8dy1", "8dy5"...
48
[ "PUB00012254", "PUB00046068" ]
[ "11781375", "15485625" ]
[ "IL-17: prototype member of an emerging cytokine family.", "Interleukin-17 family members and inflammation." ]
[ 2002, 2004 ]
2
[ "IPR010345" ]
[]
1
0
1
[ "Bilateria", "Saimiriine herpesvirus 2" ]
[ 3837, 3 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 4, 8, 11, 14 ]
4
true
Family
Interleukin-17, chordata
Interleukin-17, chordata
IL-17_chr
8
IPR020442
20,442
Interleukin-20
IL-20
Family
138
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-20 (IL-20) belongs to the family of IL-10-related cytokines, which includes IL-10, -19, -20, -2...
[ "GO:0005102" ]
[ "signaling receptor binding" ]
[ "molecular_function" ]
1
[ "PRINTS" ]
[ "PR01935" ]
[ "INTRLEUKIN20" ]
[ 138 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-8854691", "R-MMU-8854691" ]
[ "REACTOME:R-HSA-8854691", "REACTOME:R-MMU-8854691" ]
2
[]
0
[ "PUB00027532", "PUB00046044", "PUB00046072" ]
[ "12403790", "11929132", "17878297" ]
[ "Crystal structure of interleukin-19 defines a new subfamily of helical cytokines.", "The interleukin-10 family of cytokines.", "IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs." ]
[ 2003, 2002, 2007 ]
3
[ "IPR020443" ]
[]
1
0
1
[ "Euteleostomi" ]
[ 138 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 2, 3, 3 ]
3
true
Family
Interleukin-20
Interleukin-20
IL-20
2
IPR020443
20,443
Interleukin-10/19/20/24/26
IL-10/19/20/24/26
Family
3,101
false
false
This entry represents the interleukin-10, interleukin-19, interleukin-20, interleukin-24 and interleukin-26 family. Interleukin-10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T cells. Structura...
[]
[]
[]
0
[ "PFAM", "PANTHER", "SMART" ]
[ "PF00726", "PTHR48482", "SM00188" ]
[ "IL10", "", "IL10" ]
[ 2698, 3068, 1452 ]
3
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "R-GGA-6783783", "R-HSA-6783783", "R-HSA-6785807", "R-HSA-8854691", "R-HSA-8950505", "R-HSA-9609690", "R-HSA-9610379", "R-HSA-9662834", "R-HSA-9664323", "R-HSA-9725370", "R-MMU-6783783", "R-MMU-8854691", "R-RNO-6783783", "R-RNO-8854691", "R-SSC-6783783" ]
[ "REACTOME:R-GGA-6783783", "REACTOME:R-HSA-6783783", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-8854691", "REACTOME:R-HSA-8950505", "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379", "REACTOME:R-HSA-9662834", "REACTOME:R-HSA-9664323", "REACTOME:R-HSA-9725370", "REACTOME:R-MMU-6783783", "REACTOM...
15
[ "1ilk", "1inr", "1j7v", "1lk3", "1lqs", "1n1f", "1vlk", "1y6k", "1y6m", "1y6n", "2h24", "2ilk", "4doh", "4x51", "6df3", "6gg1", "6x93", "8sve" ]
18
[ "PUB00004497", "PUB00005262" ]
[ "8545104", "8590020" ]
[ "Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.", "Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma." ]
[ 1995, 1995 ]
2
[]
[ "IPR000098", "IPR020421", "IPR020442", "IPR020444" ]
0
4
0
[ "Gnathostomata", "Viruses" ]
[ 2871, 230 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 5, 15, 14, 12 ]
4
true
Family
Interleukin-10/19/20/24/26
Interleukin-10/19/20/24/26
IL-10/19/20/24/26
7
IPR020444
20,444
Interleukin-24
IL-24
Family
902
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-24 (IL-24, also known as melanoma differentiation-associated gene-7) belongs to the family of I...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01937" ]
[ "INTRLEUKIN24" ]
[ 902 ]
1
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-8854691", "R-MMU-8854691", "R-RNO-8854691" ]
[ "REACTOME:R-HSA-8854691", "REACTOME:R-MMU-8854691", "REACTOME:R-RNO-8854691" ]
3
[ "4doh", "6df3", "6gg1" ]
3
[ "PUB00046044", "PUB00046070", "PUB00046071" ]
[ "11929132", "15667561", "14508078" ]
[ "The interleukin-10 family of cytokines.", "Interleukin-24 and its receptors.", "mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic." ]
[ 2002, 2005, 2003 ]
3
[ "IPR020443" ]
[]
1
0
1
[ "Gnathostomata", "Tanapox virus" ]
[ 900, 2 ]
2
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 2, 3, 5 ]
4
true
Family
Interleukin-24
Interleukin-24
IL-24
7
IPR020445
20,445
Tumour necrosis factor receptor 4
TNFR_4
Family
606
false
false
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type I transmembrane proteins. Family members are defined based on similarity in their extracellular domain, a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a...
[ "GO:0005031", "GO:0006954" ]
[ "tumor necrosis factor receptor activity", "inflammatory response" ]
[ "molecular_function", "biological_process" ]
2
[ "PRINTS", "PANTHER" ]
[ "PR01921", "PTHR47881" ]
[ "TNFACTORR4", "" ]
[ 163, 606 ]
2
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-5669034", "R-MMU-5669034", "R-RNO-5669034" ]
[ "REACTOME:R-HSA-5669034", "REACTOME:R-MMU-5669034", "REACTOME:R-RNO-5669034" ]
3
[ "2hev", "2hey", "6ogx", "6okm", "6okn", "7yk4", "8ag1" ]
7
[ "PUB00000892", "PUB00046030", "PUB00046031", "PUB00046032", "PUB00046033", "PUB00046034", "PUB00046065" ]
[ "8387891", "7917108", "15500863", "11239407", "9826575", "9826574", "9122217" ]
[ "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.", "Tumor necrosis factor receptor superfamily members and their ligands.", "Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.", "The TNF ...
[ 1993, 1994, 2004, 2001, 1998, 1998, 1997 ]
7
[]
[]
0
0
null
[ "Bilateria" ]
[ 606 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 11, 2, 2 ]
3
true
Family
Tumour necrosis factor receptor 4
Tumour necrosis factor receptor 4
TNFR_4
7
IPR020446
20,446
NT-3 growth factor receptor NTRK3
NTRK3
Family
1,182
false
false
Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kin...
[ "GO:0004714", "GO:0005030", "GO:0006468", "GO:0007169", "GO:0005886" ]
[ "transmembrane receptor protein tyrosine kinase activity", "neurotrophin receptor activity", "protein phosphorylation", "cell surface receptor protein tyrosine kinase signaling pathway", "plasma membrane" ]
[ "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]
5
[ "PRINTS" ]
[ "PR01942" ]
[ "NTKRECEPTOR3" ]
[ 1182 ]
1
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...
[ "2.7.10.1", "R-GGA-1257604", "R-GGA-388844", "R-GGA-6811558", "R-GGA-9034013", "R-GGA-9034793", "R-GGA-9603381", "R-HSA-1257604", "R-HSA-2219530", "R-HSA-388844", "R-HSA-6811558", "R-HSA-9034013", "R-HSA-9034015", "R-HSA-9034793", "R-HSA-9034864", "R-HSA-9603381", "R-HSA-9603505", ...
[ "EC:2.7.10.1", "REACTOME:R-GGA-1257604", "REACTOME:R-GGA-388844", "REACTOME:R-GGA-6811558", "REACTOME:R-GGA-9034013", "REACTOME:R-GGA-9034793", "REACTOME:R-GGA-9603381", "REACTOME:R-HSA-1257604", "REACTOME:R-HSA-2219530", "REACTOME:R-HSA-388844", "REACTOME:R-HSA-6811558", "REACTOME:R-HSA-90340...
29
[ "1wwc" ]
1
[ "PUB00046048", "PUB00046049", "PUB00046073", "PUB00046074" ]
[ "7605062", "11520916", "8223273", "12424382" ]
[ "Functional interactions of neurotrophins and neurotrophin receptors.", "Neurotrophins: roles in neuronal development and function.", "trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.", "The neurotrophin receptor p75NTR as a positive modula...
[ 1995, 2001, 1993, 2002 ]
4
[ "IPR020777" ]
[]
1
0
1
[ "Euteleostomi" ]
[ 1182 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 10, 5, 4 ]
3
true
Family
NT-3 growth factor receptor NTRK3
NT-3 growth factor receptor NTRK3
NTRK3
2
IPR020447
20,447
Interleukin-9
IL-9
Family
343
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-9 (IL-9) is expressed primarily by activated T cells [ ]. The growth factor and anti apoptotic ...
[]
[]
[]
0
[ "PFAM", "PRINTS", "PANTHER" ]
[ "PF27789", "PR01926", "PTHR16926" ]
[ "IL-9", "INTERLEUKIN9", "" ]
[ 343, 156, 333 ]
3
[ "REACTOME", "REACTOME" ]
[ "R-HSA-8985947", "R-MMU-8985947" ]
[ "REACTOME:R-HSA-8985947", "REACTOME:R-MMU-8985947" ]
2
[ "7ox1", "7ox2", "7ox3", "7ox4", "7ox5", "7ox6", "7xcb" ]
7
[ "PUB00046075", "PUB00046076", "PUB00046077" ]
[ "15210765", "15621723", "11070175" ]
[ "Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines.", "IL-9 and its receptor: from signal transduction to tumorigenesis.", "IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyp...
[ 2004, 2004, 2000 ]
3
[]
[]
0
0
null
[ "Tetrapoda" ]
[ 343 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 3, 1, 2 ]
3
true
Family
Interleukin-9
Interleukin-9
IL-9
7
IPR020449
20,449
Transcription regulator HTH, AraC- type, HTH domain
Tscrpt_reg_AraC-type_HTH
Domain
195,749
false
false
Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including AppY, EnvY, ExsA, FapR, MmsR, RhaR, R...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR00032" ]
[ "HTHARAC" ]
[ 195749 ]
1
[]
[]
[]
0
[ "1d5y", "2k9s", "3gbg", "3lsg", "3mkl", "3oio", "3oou", "4fe4", "4fe7", "4mlo", "5suw", "5sux", "6p7r", "6p7t", "6pb9", "6swi", "6xiu", "6xiv", "7bef", "7beg", "7r3w", "7vwy", "7vwz", "7w5w", "7w5x", "7w5y", "8vrq", "8vst", "9ca5", "9ca6", "9gfp" ]
31
[ "PUB00002138", "PUB00002154", "PUB00002721" ]
[ "1708380", "1655713", "1339433" ]
[ "Two divergently transcribed genes, soxR and soxS, control a superoxide response regulon of Escherichia coli.", "Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa.", "Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding ...
[ 1991, 1991, 1992 ]
3
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]
[ 194734, 126, 21, 10, 858 ]
5
[ "Escherichia coli (strain K12)" ]
[ 29 ]
1
true
Domain
Transcription regulator HTH, AraC- type, HTH domain
Transcription regulator HTH, AraC- type, HTH domain
Tscrpt_reg_AraC-type_HTH
8
IPR020450
20,450
Interleukin-16
IL-16
Family
910
false
false
This entry represents human interleukin-16 (IL-16) and similar sequences mainly found in mammals and aves. Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. ...
[ "GO:0005125" ]
[ "cytokine activity" ]
[ "molecular_function" ]
1
[ "PRINTS" ]
[ "PR01931" ]
[ "INTRLEUKIN16" ]
[ 910 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-449836", "R-MMU-449836" ]
[ "REACTOME:R-HSA-449836", "REACTOME:R-MMU-449836" ]
2
[ "1x6d" ]
1
[ "PUB00046078", "PUB00046079", "PUB00155303", "PUB00155304" ]
[ "7910967", "16881862", "16271292", "16387589" ]
[ "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.", "Not-so-sweet sixteen: the role of IL-16 in infectious and immune-mediated inflammatory diseases.", "Increased levels of bioactive IL-16 correlate with disease activity during relap...
[ 1994, 2006, 2005, 2006 ]
4
[ "IPR055287" ]
[]
1
0
1
[ "Bilateria" ]
[ 910 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 10, 2, 6 ]
3
true
Family
Interleukin-16
Interleukin-16
IL-16
8
IPR020451
20,451
Interleukin-15, avian
IL-15_avian
Family
333
false
false
Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-15 (IL-15) has a variety of biological functions, including stimulation and maintenance of cell...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01948" ]
[ "INTLKN15BIRD" ]
[ 333 ]
1
[]
[]
[]
0
[]
0
[ "PUB00019742", "PUB00046028", "PUB00046080" ]
[ "10689297", "10784451", "11587737" ]
[ "The emerging role of IL-15 in NK-cell development.", "Control of homeostasis of CD8+ memory T cells by opposing cytokines.", "Molecular, cellular, and functional characterization of chicken cytokines homologous to mammalian IL-15 and IL-2." ]
[ 2000, 2000, 2001 ]
3
[ "IPR020439" ]
[]
1
0
1
[ "Archelosauria" ]
[ 333 ]
1
[]
[]
0
true
Family
Interleukin-15, avian
Interleukin-15, avian
IL-15_avian
6
IPR020452
20,452
Subtilin biosynthesis protein SpaC
Subtilin_biosynthesis_SpaC
Family
54
false
false
The LanC-like protein superfamily encompasses a highly divergent group of peptide-modifying enzymes, including the eukaryotic and bacterial lanthionine synthetase C-like proteins (LanC) [ , , ]; subtilin biosynthesis protein SpaC from Bacillus subtilis [ , ]; epidermin biosynthesis protein EpiC from Staphylococcus epid...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR01953" ]
[ "SPACPROTEIN" ]
[ 54 ]
1
[]
[]
[]
0
[ "8byk" ]
1
[ "PUB00002161", "PUB00008599", "PUB00011680", "PUB00018966", "PUB00035552", "PUB00040886", "PUB00046016", "PUB00046017", "PUB00046018", "PUB00046021", "PUB00046022", "PUB00046023", "PUB00046024", "PUB00046051", "PUB00046081" ]
[ "1735728", "1539969", "8161176", "1740156", "17347412", "16527981", "11474189", "10944443", "12566319", "1482192", "9512664", "18086512", "17894782", "7689965", "14622008" ]
[ "The subtilin gene of Bacillus subtilis ATCC 6633 is encoded in an operon that contains a homolog of the hemolysin B transport protein.", "Analysis of genes involved in biosynthesis of the lantibiotic subtilin.", "Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3.", "Analysis of genes in...
[ 1992, 1992, 1994, 1992, 2007, 2006, 2001, 2000, 2003, 1992, 1998, 2008, 2007, 1993, 2003 ]
15
[ "IPR033889" ]
[]
1
0
1
[ "Bacillota" ]
[ 54 ]
1
[]
[]
0
true
Family
Subtilin biosynthesis protein SpaC
Subtilin biosynthesis protein SpaC
Subtilin_biosynthesis_SpaC
8
IPR020453
20,453
Interleukin-22
IL-22
Family
865
false
false
This entry represents interleukin-22. Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.
[ "GO:0005576" ]
[ "extracellular region" ]
[ "cellular_component" ]
1
[ "PFAM", "PIRSF", "PRINTS", "PANTHER" ]
[ "PF14565", "PIRSF037726", "PR01936", "PTHR48488" ]
[ "IL22", "Interleukin-22", "INTRLEUKIN22", "" ]
[ 815, 14, 626, 812 ]
4
[ "REACTOME", "REACTOME", "REACTOME" ]
[ "R-HSA-8854691", "R-HSA-9725370", "R-MMU-8854691" ]
[ "REACTOME:R-HSA-8854691", "REACTOME:R-HSA-9725370", "REACTOME:R-MMU-8854691" ]
3
[ "1m4r", "1ykb", "3dgc", "3dlq", "3g9v", "3q1s", "6weo" ]
7
[ "PUB00046044", "PUB00046082", "PUB00046083" ]
[ "11929132", "15308104", "18264109" ]
[ "The interleukin-10 family of cytokines.", "IL-22 increases the innate immunity of tissues.", "Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens." ]
[ 2002, 2004, 2008 ]
3
[]
[]
0
0
null
[ "Gnathostomata" ]
[ 865 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 5, 5, 4 ]
3
true
Family
Interleukin-22
Interleukin-22
IL-22
8
IPR020454
20,454
Diacylglycerol/phorbol-ester binding
DAG/PE-bd
Domain
38,012
false
false
This entry represents the N-terminal region of PKC, known as C1. It has been shown to bind PE and DAG in a phospholipid and zinc-dependent fashion [ ]. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential...
[]
[]
[]
0
[ "PRINTS" ]
[ "PR00008" ]
[ "DAGPEDOMAIN" ]
[ 38012 ]
1
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...
[ "2.7.11.13", "R-BTA-114516", "R-BTA-1169091", "R-BTA-416993", "R-BTA-4419969", "R-BTA-5099900", "R-BTA-5218921", "R-BTA-5668599", "R-BTA-76005", "R-CEL-111465", "R-CEL-111933", "R-CEL-114508", "R-CEL-114516", "R-CEL-1169091", "R-CEL-1433559", "R-CEL-1489509", "R-CEL-1660661", "R-CE...
[ "EC:2.7.11.13", "REACTOME:R-BTA-114516", "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-416993", "REACTOME:R-BTA-4419969", "REACTOME:R-BTA-5099900", "REACTOME:R-BTA-5218921", "REACTOME:R-BTA-5668599", "REACTOME:R-BTA-76005", "REACTOME:R-CEL-111465", "REACTOME:R-CEL-111933", "REACTOME:R-CEL-114508",...
268
[ "1faq", "1far", "1ptq", "1ptr", "1tbn", "1tbo", "1xa6", "1y8f", "2e73", "2eli", "2enn", "2enz", "2yuu", "3cxl", "3pfq", "3uej", "3uey", "3uff", "3ugd", "3ugi", "3ugl", "4fkd", "4l9m", "6nyb", "6pts", "6ptw", "6q0j", "6q0k", "6q0t", "6ra0", "6uan", "6uwa"...
78
[ "PUB00001427", "PUB00004685" ]
[ "1396661", "2500657" ]
[ "The protein kinase C family.", "Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence." ]
[ 1992, 1989 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 38012 ]
1
[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 28, 99, 30, 132, 82, 1, 123, 1 ]
8
true
Domain
Diacylglycerol/phorbol-ester binding
Diacylglycerol/phorbol-ester binding
DAG/PE-bd
1
IPR020455
20,455
BDNF/NT-3 growth factors receptor NTRK2
NTRK2
Family
1,081
false
false
Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kin...
[ "GO:0004714", "GO:0005030", "GO:0006468", "GO:0007169", "GO:0005886" ]
[ "transmembrane receptor protein tyrosine kinase activity", "neurotrophin receptor activity", "protein phosphorylation", "cell surface receptor protein tyrosine kinase signaling pathway", "plasma membrane" ]
[ "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]
5
[ "PRINTS" ]
[ "PR01941" ]
[ "NTKRECEPTOR2" ]
[ 1081 ]
1
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...
[ "2.7.10.1", "R-GGA-1257604", "R-GGA-6811558", "R-GGA-9026527", "R-GGA-9028731", "R-GGA-9032759", "R-HSA-1257604", "R-HSA-187024", "R-HSA-2219530", "R-HSA-6811558", "R-HSA-9024909", "R-HSA-9025046", "R-HSA-9026357", "R-HSA-9026519", "R-HSA-9026527", "R-HSA-9028335", "R-HSA-9028731", ...
[ "EC:2.7.10.1", "REACTOME:R-GGA-1257604", "REACTOME:R-GGA-6811558", "REACTOME:R-GGA-9026527", "REACTOME:R-GGA-9028731", "REACTOME:R-GGA-9032759", "REACTOME:R-HSA-1257604", "REACTOME:R-HSA-187024", "REACTOME:R-HSA-2219530", "REACTOME:R-HSA-6811558", "REACTOME:R-HSA-9024909", "REACTOME:R-HSA-9025...
30
[ "1hcf", "1wwb", "5mo9" ]
3
[ "PUB00046048", "PUB00046049", "PUB00046084", "PUB00046085", "PUB00046086" ]
[ "7605062", "11520916", "17192812", "11836532", "12719654" ]
[ "Functional interactions of neurotrophins and neurotrophin receptors.", "Neurotrophins: roles in neuronal development and function.", "Transcriptional regulation of Trk family neurotrophin receptors.", "TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum.", "Brain-d...
[ 1995, 2001, 2007, 2002, 2003 ]
5
[ "IPR020777" ]
[]
1
0
1
[ "Euteleostomi" ]
[ 1081 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 14, 7, 7 ]
3
true
Family
BDNF/NT-3 growth factors receptor NTRK2
BDNF/NT-3 growth factors receptor NTRK2
NTRK2
2