LiteFold/InterPro · Datasets at Hugging Face

IPR022422

22,422

Protein import receptor MAS20, metazoan

MAS20_rcpt_metazoan

Family

2,217

false

Virtually all mitochondrial precursors are imported via the same mechanism [ ]: precursors first bind to receptors on the mitochondrial surface, then insert into the translocation channel in the outer membrane. Many outer-membrane proteins participate in the early stages of import, 4 of which (MAS20, MAS22, MAS37 and M...

[ "GO:0006605", "GO:0006886", "GO:0005742" ]

[ "protein targeting", "intracellular protein transport", "mitochondrial outer membrane translocase complex" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01989" ]

[ "EUOM20RECPTR" ]

[ 2217 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5205685", "R-BTA-5689880", "R-CEL-5205685", "R-CEL-5689880", "R-DRE-5205685", "R-DRE-5689880", "R-HSA-1268020", "R-HSA-5205685", "R-HSA-5689880", "R-MMU-5205685", "R-MMU-5689880", "R-RNO-5205685", "R-RNO-5689880", "R-XTR-5205685", "R-XTR-5689880" ]

[ "REACTOME:R-BTA-5205685", "REACTOME:R-BTA-5689880", "REACTOME:R-CEL-5205685", "REACTOME:R-CEL-5689880", "REACTOME:R-DRE-5205685", "REACTOME:R-DRE-5689880", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-5205685", "REACTOME:R-HSA-5689880", "REACTOME:R-MMU-5205685", "REACTOME:R-MMU-5689880", "REACTOM...

15

[ "1om2", "2v1s", "2v1t", "3awr", "3ax2", "3ax3", "3ax5", "7vby", "7vc9", "8uy3", "8xva", "9eih", "9eii", "9eij", "9j79", "9j7a", "9j7b", "9jce" ]

18

[ "PUB00002838", "PUB00005448", "PUB00022363", "PUB00053684" ]

[ "8163528", "7709435", "10721992", "7589431" ]

[ "Mitochondrial Mas70p signal anchor sequence. Mutations in the transmembrane domain that disrupt dimerization but not targeting or membrane insertion.", "The protein import receptor of mitochondria.", "Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20.", "Identific...

[ 1994, 1995, 2000, 1995 ]

4

[ "IPR002056" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2217 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 4, 2, 4, 6 ]

6

true

Family

Protein import receptor MAS20, metazoan

MAS20_rcpt_metazoan

4

IPR022423

22,423

Neurohypophysial hormone, conserved site

Neurohypophysial_hormone_CS

Conserved_site

2,037

false

Oxytocin (or ocytocin) and vasopressin [ ] are small (nine amino acid residues), structurally and functionally related neurohypophysial peptide hormones. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland while vasopressin has a direct antidiuretic action on the kidney and also caus...

[ "GO:0005185", "GO:0005576" ]

[ "neurohypophyseal hormone activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PROSITE" ]

[ "PF00220", "PS00264" ]

[ "Hormone_4", "NEUROHYPOPHYS_HORM" ]

[ 1407, 2034 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-388479", "R-BTA-416476", "R-HSA-1368108", "R-HSA-388479", "R-HSA-416476", "R-HSA-418555", "R-HSA-432040", "R-HSA-5619099", "R-HSA-879518", "R-HSA-8856825", "R-HSA-8856828", "R-HSA-9036092", "R-MMU-388479", "R-MMU-416476", "R-MMU-418555", "R-MMU-432040", "R-MMU-879518", "R-MM...

[ "REACTOME:R-BTA-388479", "REACTOME:R-BTA-416476", "REACTOME:R-HSA-1368108", "REACTOME:R-HSA-388479", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-418555", "REACTOME:R-HSA-432040", "REACTOME:R-HSA-5619099", "REACTOME:R-HSA-879518", "REACTOME:R-HSA-8856825", "REACTOME:R-HSA-8856828", "REACTOME:R-HSA...

32

[ "1jk4", "1npo", "1xy1", "1xy2", "1yf4", "2mgo", "7bb6", "7bb7", "7dw9", "7kh0", "7ofg", "7otd", "7qvm", "7r0c", "7ryc" ]

15

[ "PUB00000683", "PUB00002048" ]

[ "3147712", "7591488" ]

[ "Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors.", "A new neurohypophysial peptide, seritocin ([Ser5,Ile8]-oxytocin), identified in a dryness-resistant African toad, Bufo regularis." ]

[ 1988, 1995 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 32, 2005 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 6, 3 ]

4

true

Conserved_site

Neurohypophysial hormone, conserved site

Neurohypophysial_hormone_CS

5

IPR022424

22,424

Translation initiation factor 2, gamma subunit

TIF2_gsu

Family

923

false

This entry represents the gamma subunit of archaeal translation initiation factor 2, it is found in all known archaea. eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [ ].

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_00119", "TIGR03680" ]

[ "eIF_2_gamma", "eif2g_arch" ]

[ 687, 923 ]

2

[ "EC" ]

[ "3.6.5.3" ]

[ "EC:3.6.5.3" ]

1

[ "1kjz", "1kk0", "1kk1", "1kk2", "1kk3", "1s0u", "2aho", "2d74", "2dcu", "2plf", "2pmd", "2qmu", "2qn6", "3cw2", "3i1f", "3pen", "3qsy", "3sjz", "3v11", "4m0l", "4m2l", "4m4s", "4m53", "4nbs", "4qfm", "4qhy", "4rcy", "4rcz", "4rd0", "4rd1", "4rd2", "4rd3"...

44

[ "PUB00049070" ]

[ "18000047" ]

[ "Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 893, 2, 5, 23 ]

4

[]

0

true

Family

Translation initiation factor 2, gamma subunit

TIF2_gsu

3

IPR022425

22,425

Flagellar export ATPase FliI, clade 2

FliI_clade2

Family

2,492

false

Members of this protein family are the FliI protein of bacterial flagellum systems. FliI is an ATPase that acts to drive protein export for flagellar biosynthesis [ ]. The most closely related family is the YscN family of bacterial type III secretion systems. This entry represents one (of three) segment of the FliI fam...

[ "GO:0016887", "GO:0044780", "GO:0071973" ]

[ "ATP hydrolysis activity", "bacterial-type flagellum assembly", "bacterial-type flagellum-dependent cell motility" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR03497" ]

[ "FliI_clade2" ]

[ 2492 ]

1

[ "GP" ]

[ "GenProp0879" ]

[ "GP:GenProp0879" ]

1

[]

0

[ "PUB00067606" ]

[ "1828465" ]

[ "The flaA locus of Bacillus subtilis is part of a large operon coding for flagellar structures, motility functions, and an ATPase-like polypeptide." ]

[ 1991 ]

1

[ "IPR005714" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 2476, 16 ]

2

[]

0

true

Family

Flagellar export ATPase FliI, clade 2

FliI_clade2

8

IPR022426

22,426

Flagellum-specific ATP synthase FliI, clade 3

FliI_clade3

Family

1,633

false

This family represent the bacterial flagellum-specific ATP synthase, FliI, which is needed for flagellar assembly. FliI is part of the flagellar type III protein export apparatus acting as an ATPase to drive protein export for flagellar biosynthesis [ , , ]. When FliI is not engaged in flagellar protein export, FliH, a...

[ "GO:0016887", "GO:0044781", "GO:0009288", "GO:0030257" ]

[ "ATP hydrolysis activity", "bacterial-type flagellum organization", "bacterial-type flagellum", "type III protein secretion system complex" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR03498" ]

[ "FliI_clade3" ]

[ 1633 ]

1

[ "EC", "GP", "METACYC" ]

[ "7.1.2.2", "GenProp0879", "PWY-7980" ]

[ "EC:7.1.2.2", "GP:GenProp0879", "METACYC:PWY-7980" ]

3

[]

0

[ "PUB00034694", "PUB00060934", "PUB00060935", "PUB00060936", "PUB00060937", "PUB00060938", "PUB00060939" ]

[ "17012787", "8943245", "10998179", "19889085", "12180917", "9286988", "9231413" ]

[ "Crystallization and preliminary X-ray analysis of Salmonella FliI, the ATPase component of the type III flagellar protein-export apparatus.", "Enzymatic characterization of FliI. An ATPase involved in flagellar assembly in Salmonella typhimurium.", "FliH, a soluble component of the type III flagellar export ap...

[ 2006, 1996, 2000, 2009, 2002, 1997, 1997 ]

7

[ "IPR005714" ]

[]

1

0

1

[ "Arthropoda", "Bacteria", "metagenomes" ]

[ 2, 1622, 9 ]

3

[]

0

true

Family

Flagellum-specific ATP synthase FliI, clade 3

FliI_clade3

6

IPR022427

22,427

Uncharacterised protein MJ0570, ATP-binding

MJ0570_ATP-bd

Family

910

false

This entry represents possible ATP binding proteins from Archaea, including the uncharacterised protein MJ0570 from Methanocaldococcus jannaschii and PF0828 from Pyrococcus furiosus ( , ). This protein consists of an N-terminal possible metal-binding domain followed by a possible C-terminal ABC transporter, ATP-binding...

[]

0

[ "NCBIFAM" ]

[ "TIGR03679" ]

[ "arCOG00187" ]

[ 910 ]

1

[]

0

[ "2d13", "3rjz", "3rk0", "3rk1" ]

4

[ "PUB00045375", "PUB00057618", "PUB00063482" ]

[ "18042280", "22102225", "23013770" ]

[ "Clusters of orthologous genes for 41 archaeal genomes and implications for evolutionary genomics of archaea.", "A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding.", "Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis...

[ 2007, 2011, 2012 ]

3

[ "IPR030662" ]

[ "IPR005237" ]

1

0

[ "Archaea", "Candidatus Segetimicrobium genomatis", "Eukaryota", "ecological metagenomes" ]

[ 869, 1, 19, 21 ]

4

[]

0

true

Family

Uncharacterised protein MJ0570, ATP-binding

MJ0570_ATP-bd

6

IPR022429

22,429

Alanine-tRNA ligase, archaea

Ala-tRNA_lgiase_arc

Family

962

false

Alanine-tRNA ligase catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). It also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. This family of alanine-tRNA liga...

[ "GO:0000166", "GO:0006419", "GO:0005737" ]

[ "nucleotide binding", "alanyl-tRNA aminoacylation", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_00036_A", "TIGR03683" ]

[ "Ala_tRNA_synth_A", "A-tRNA_syn_arch" ]

[ 944, 915 ]

2

[ "EC" ]

[ "6.1.1.7" ]

[ "EC:6.1.1.7" ]

1

[ "2ztg", "2zze", "2zzf", "2zzg", "3wqy", "3wqz" ]

6

[ "PUB00000386", "PUB00000723", "PUB00004391", "PUB00005365", "PUB00006477", "PUB00007191", "PUB00007363", "PUB00079872", "PUB00079873" ]

[ "8364025", "8274143", "1852601", "2053131", "10673435", "2203971", "10447505", "10704480", "12458790" ]

[ "Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.", "The aminoacyl-tRNA synthetase family: modules at work.", "Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.", "Classes of aminoacyl-tRNA synthetases and the establ...

[ 1993, 1993, 1991, 1991, 2000, 1990, 1999, 2000, 2002 ]

9

[ "IPR002318" ]

[]

1

0

1

[ "Archaea", "Candidatus Rhodobacter oscarellae", "Eukaryota", "unclassified sequences" ]

[ 899, 1, 47, 15 ]

4

[]

0

true

Family

Alanine-tRNA ligase, archaea

Ala-tRNA_lgiase_arc

3

IPR022430

22,430

Conserved hypothetical protein CHP03684

CHP03684

Family

829

false

This universal archaeal protein [ ] contains a C-terminal PUA domain possibly associated with RNA-binding.

[]

0

[ "NCBIFAM" ]

[ "TIGR03684" ]

[ "arCOG00985" ]

[ 829 ]

1

[]

0

[ "1q7h", "1zs7", "2cx0", "2cx1", "3d79" ]

5

[ "PUB00045375" ]

[ "18042280" ]

[ "Clusters of orthologous genes for 41 archaeal genomes and implications for evolutionary genomics of archaea." ]

[ 2007 ]

1

[ "IPR016437" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 807, 2, 20 ]

3

[]

0

true

Family

Conserved hypothetical protein CHP03684

CHP03684

1

IPR022431

22,431

Cyclic dehypoxanthine futalosine synthase

Cyclic_DHFL_synthase_mqnC

Family

3,584

false

Members of this protein family are involved in menaquinone biosynthesis by an alternate pathway via futalosine [ , ].

[ "GO:0009234" ]

[ "menaquinone biosynthetic process" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_00992", "TIGR03699" ]

[ "MqnC", "menaquin_MqnC" ]

[ 3224, 3549 ]

2

[ "GP" ]

[ "GenProp0829" ]

[ "GP:GenProp0829" ]

1

[]

0

[ "PUB00045374", "PUB00074049" ]

[ "18801996", "23763543" ]

[ "An alternative menaquinone biosynthetic pathway operating in microorganisms.", "In vitro reconstitution of the radical S-adenosylmethionine enzyme MqnC involved in the biosynthesis of futalosine-derived menaquinone." ]

[ 2008, 2013 ]

2

[ "IPR034405" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 116, 3413, 6, 49 ]

4

[]

0

true

Family

Cyclic dehypoxanthine futalosine synthase

Cyclic_DHFL_synthase_mqnC

7

IPR022432

22,432

Aminodeoxyfutalosine synthase

MqnE

Family

3,464

false

Members of this protein family are aminofutalosine synthases (MqnE, ) and are involved in menaquinone biosynthesis. The Thermus thermophilus family member, MqnE, has been experimentally characterised as a a radical SAM enzyme that catalyses the addition of the adenosyl radical to the double bond of 3-[(1 -carboxyvinyl)...

[ "GO:0009234" ]

[ "menaquinone biosynthetic process" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_00993", "TIGR03700" ]

[ "MqnE", "mena_SCO4494" ]

[ 3312, 3431 ]

2

[ "GP" ]

[ "GenProp0829" ]

[ "GP:GenProp0829" ]

1

[ "6xi9", "6xig" ]

2

[ "PUB00074152", "PUB00098897" ]

[ "24083939", "32627538" ]

[ "Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme.", "Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis." ]

[ 2013, 2020 ]

2

[ "IPR020050" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "ecological metagenomes" ]

[ 3406, 3, 13, 42 ]

4

[]

0

true

Family

Aminodeoxyfutalosine synthase

MqnE

1

IPR022433

22,433

Lipid kinase YegS

Lip_kinase_YegS

Family

2,673

false

Members of this protein family are designated YegS, an apparent lipid kinase family in the Proteobacteria. The crystal structure of YegS has been reported and been shown to be a lipid kinase with phosphatidylglycerol kinase activity. The crystal structure reveals a two-domain protein with significant structural similar...

[ "GO:0001727", "GO:0046872" ]

[ "lipid kinase activity", "metal ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "NCBIFAM", "NCBIFAM" ]

[ "MF_01377", "NF009602", "TIGR03702" ]

[ "YegS", "PRK13054.1", "lip_kinase_YegS" ]

[ 2397, 2668, 2285 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.-", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-6626", "PWY-6682", "PWY-6955", "PWY-7077", "PWY-7321", "PWY-7740", "PWY-7769", "PWY-7886", "PWY-7948", "PWY-7975", "PWY-8129", "PWY-8324", "PWY-8367", "PWY-8392", "PWY-8393", "PWY-8394", "PWY-8402" ]

[ "EC:2.7.1.-", "METACYC:PWY-5129", "METACYC:PWY-6322", "METACYC:PWY-6369", "METACYC:PWY-6626", "METACYC:PWY-6682", "METACYC:PWY-6955", "METACYC:PWY-7077", "METACYC:PWY-7321", "METACYC:PWY-7740", "METACYC:PWY-7769", "METACYC:PWY-7886", "METACYC:PWY-7948", "METACYC:PWY-7975", "METACYC:PWY-8...

21

[ "2bon", "2jgr", "2p1r" ]

3

[ "PUB00039707" ]

[ "17351295" ]

[ "Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site." ]

[ 2007 ]

1

[ "IPR005218" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2661, 6, 6 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Lipid kinase YegS

Lip_kinase_YegS

8

IPR022434

22,434

ABC transporter, LPXTG-anchor lipoprotein, actinobacteria

ABC_LPXTG_lipo_actinobac

Family

484

false

Members of this protein family are ABC transporter permease subunits as identified by , but additionally contain the Actinobacterial insert domain described by . Some homologues (lacking the insert) have been described as transporters of manganese or of chelated iron. Members of this family typically are found along wi...

[]

0

[ "NCBIFAM" ]

[ "TIGR03772" ]

[ "anch_rpt_subst" ]

[ 484 ]

1

[ "GP" ]

[ "GenProp0857" ]

[ "GP:GenProp0857" ]

1

[]

0

[]

0

[ "IPR006129" ]

[]

1

0

1

[ "Actinomycetota" ]

[ 484 ]

1

[]

0

true

Family

ABC transporter, LPXTG-anchor lipoprotein, actinobacteria

ABC_LPXTG_lipo_actinobac

3

IPR022435

22,435

Surface-anchored repeat, actinobacteria

Surface-anchored_actinobac

Repeat

2,311

false

This entry describes a region that occurs from one to three times in proteins from Actinobacteria, some of which have LPXTG-type sortase recognition motifs for covalent attachment to the Gram-positive cell wall. The region is now recognized as a "choice-of-anchor" domain, since multiple members can be found anchored by...

[]

0

[ "NCBIFAM" ]

[ "TIGR03769" ]

[ "P_ac_wall_RPT" ]

[ 2311 ]

1

[ "GP" ]

[ "GenProp0857" ]

[ "GP:GenProp0857" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Siphoviridae sp. ctJyX12" ]

[ 2310, 1 ]

2

[]

0

true

Repeat

Surface-anchored repeat, actinobacteria

Surface-anchored_actinobac

7

IPR022436

22,436

Rickettsia palindromic element RPE2

RPE2

Domain

161

false

This entry describes a family, family 2, of Rickettsia palindromic elements (RPE2). The elements spread within a genome as selfish genetic elements, inserting into genes creating additional coding regions that do not disrupt the reading frame. This model finds RPE-encoded regions in several Rickettsial species and, so ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03774" ]

[ "RPE2" ]

[ 161 ]

1

[ "GP" ]

[ "GenProp0476" ]

[ "GP:GenProp0476" ]

1

[]

0

[]

0

[]

0

null

[ "Pseudolycoriella hygida", "Rickettsieae" ]

[ 2, 159 ]

2

[]

0

true

Domain

Rickettsia palindromic element RPE2

RPE2

5

IPR022437

22,437

Rickettsia palindromic element RPE3

RPE3

Domain

180

false

This entry represents family 3 of Rickettsia palindromic elements (RPE3). These elements spread within a genome as selfish genetic elements, inserting into genes creating additional coding regions that do not disrupt the reading frame (ORF), but are expressed as part of the proteins encoded by them [ , , ]. Members of ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03775" ]

[ "RPE3" ]

[ 180 ]

1

[ "GP" ]

[ "GenProp0476" ]

[ "GP:GenProp0476" ]

1

[]

0

[ "PUB00017620", "PUB00100111", "PUB00100112" ]

[ "11030655", "12575994", "11997347" ]

[ "Selfish DNA in protein-coding genes of Rickettsia.", "The insertion of palindromic repeats in the evolution of proteins.", "Protein coding palindromes are a unique but recurrent feature in Rickettsia." ]

[ 2000, 2003, 2002 ]

3

[]

0

null

[ "Oppiella nova", "Rickettsia" ]

[ 1, 179 ]

2

[]

0

true

Domain

Rickettsia palindromic element RPE3

RPE3

4

IPR022438

22,438

Rickettsia palindromic element 5

RPE5

Domain

148

false

This entry represents family 5 of Rickettsia palindromic elements (RPE5). These elements spread within a genome as selfish genetic elements, inserting into genes creating additional coding regions that do not disrupt the reading frame (ORF), but are expressed as part of the proteins encoded by them [ , , ]. Members of ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03776" ]

[ "RPE5" ]

[ 148 ]

1

[ "GP" ]

[ "GenProp0476" ]

[ "GP:GenProp0476" ]

1

[]

0

[ "PUB00017620", "PUB00100111", "PUB00100112" ]

[ "11030655", "12575994", "11997347" ]

[ "Selfish DNA in protein-coding genes of Rickettsia.", "The insertion of palindromic repeats in the evolution of proteins.", "Protein coding palindromes are a unique but recurrent feature in Rickettsia." ]

[ 2000, 2003, 2002 ]

3

[]

0

null

[ "Rickettsia" ]

[ 148 ]

1

[]

0

true

Domain

Rickettsia palindromic element 5

RPE5

4

IPR022439

22,439

Rickettsia palindromic element RPE4

RPE4

Domain

192

false

This entry represents Rickettsia palindromic element RPE4, a palindromic element found in several Rickettsial species. The elements spread within a genome as selfish genetic elements, inserting into genes creating additional coding regions that do not disrupt the reading frame.

[]

0

[ "NCBIFAM" ]

[ "TIGR03777" ]

[ "RPE4" ]

[ 192 ]

1

[ "GP" ]

[ "GenProp0476" ]

[ "GP:GenProp0476" ]

1

[]

0

[]

0

[]

0

null

[ "Pseudomonadota" ]

[ 192 ]

1

[]

0

true

Domain

Rickettsia palindromic element RPE4

RPE4

2

IPR022440

22,440

Conserved hypothetical protein CHP03788

CHP03788

Family

839

false

Members of this protein family are restricted to the Proteobacteria. Each contains a C-terminal sortase-recognition motif, transmembrane domain, and basic residues cluster at the the C terminus, and is encoded adjacent to a sortase gene. This protein is frequently the only sortase target in its genome, which is as unus...

[]

0

[ "NCBIFAM" ]

[ "TIGR03788" ]

[ "marine_srt_targ" ]

[ 839 ]

1

[ "GP" ]

[ "GenProp0859" ]

[ "GP:GenProp0859" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 821, 18 ]

2

[]

0

true

Family

Conserved hypothetical protein CHP03788

CHP03788

8

IPR022441

22,441

Parallel beta-helix repeat-2

Para_beta_helix_rpt-2

Repeat

14,081

false

This model represents a tandem pair of an approximately 22-amino acid (each) repeat homologous to the β-strand repeats that stack in a right-handed parallel β-helix in the periplasmic C-5 mannuronan epimerase, AlgA, of Pseudomonas aeruginosa. A homology domain consisting of a longer tandem array of these repeats is des...

[]

0

[ "NCBIFAM" ]

[ "TIGR03804" ]

[ "para_beta_helix" ]

[ 14081 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-8951664", "R-CEL-983168", "R-HSA-8951664", "R-HSA-983168", "R-MMU-8951664", "R-MMU-983168", "R-RNO-8951664", "R-RNO-983168" ]

[ "REACTOME:R-CEL-8951664", "REACTOME:R-CEL-983168", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-8951664", "REACTOME:R-MMU-983168", "REACTOME:R-RNO-8951664", "REACTOME:R-RNO-983168" ]

8

[ "3zpp", "4nk6", "4nk8", "4ozy", "4ozz", "5z9t", "6a40", "6itg", "7bz0", "7o0y", "7o10", "7o11", "7o12", "7o13", "7o14", "7o15", "7o16", "7o17", "7osf", "7osg", "7osh", "7osi", "7osj", "7qba", "7znq" ]

25

[ "PUB00007977" ]

[ "11852237" ]

[ "CASH--a beta-helix domain widespread among carbohydrate-binding proteins." ]

[ 2002 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1891, 7089, 4375, 26, 700 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 7, 2, 9, 6, 10 ]

6

true

Repeat

Parallel beta-helix repeat-2

Para_beta_helix_rpt-2

6

IPR022442

22,442

SO_2930-like, beta-helix domain

SO_2930-like_dom

Domain

1,225

false

This entry represents a domain found in a group of uncharacterised diheme c-type cytochrome proteins that contain repeats associated with the formation of a right-handed helical stack of parallel β-strands, homologous to those found in a number of carbohydrate-binding proteins and sugar hydrolases. Each repeat is expec...

[]

0

[ "NCBIFAM" ]

[ "TIGR03805" ]

[ "beta_helix_1" ]

[ 1225 ]

1

[]

0

[]

0

[ "PUB00106780" ]

[ "23811511" ]

[ "Combined genomics and experimental analyses of respiratory characteristics of Shewanella putrefaciens W3-18-1." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1184, 3, 38 ]

3

[]

0

true

Domain

SO_2930-like, beta-helix domain

SO_2930-like_dom

3

IPR022444

22,444

Cofactor-binding repeat, putative

Cofactor-bd_rpt

Repeat

659

false

This entry describes a small repeat found in a family of proteins that crosses the plasma membrane by twin-arginine translation, which usually signifies the presence of a bound cofactor. This repeat shows similarity to the β-helical repeat, in which three β-strands per repeat wind once per repeat around in a right-hand...

[]

0

[ "NCBIFAM" ]

[ "TIGR03807" ]

[ "RR_fam_repeat" ]

[ 659 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 631, 22, 6 ]

3

[]

0

true

Repeat

Cofactor-binding repeat, putative

Cofactor-bd_rpt

3

IPR022445

22,445

Sortase, proteobacterial type

Sortase_proteobact_type

Family

837

false

This entry represents the GN class sortase, which includes sortase enzymes, cysteine transpeptidases involved in protein sorting activities, from Gram-negative bacteria, mainly proteobacteria, in a dedicated system with apparently only one target protein, a member of . Many of these sortases appear to contain a signal ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03784" ]

[ "marine_sortase" ]

[ 837 ]

1

[ "GP" ]

[ "GenProp0859" ]

[ "GP:GenProp0859" ]

1

[]

0

[ "PUB00053707" ]

[ "15102780" ]

[ "A comparative genome analysis identifies distinct sorting pathways in gram-positive bacteria." ]

[ 2004 ]

1

[ "IPR041999" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 815, 22 ]

2

[]

0

true

Family

Sortase, proteobacterial type

Sortase_proteobact_type

8

IPR022446

22,446

N5-glutamine methyltransferase, putative

MeTrfrase_put

Family

2,710

false

This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine si...

[]

0

[ "NCBIFAM" ]

[ "TIGR03704" ]

[ "PrmC_rel_meth" ]

[ 2710 ]

1

[]

0

[]

0

[]

0

[ "IPR004556" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 2703, 7 ]

2

[]

0

true

Family

N5-glutamine methyltransferase, putative

MeTrfrase_put

3

IPR022447

22,447

Lysine-2,3-aminomutase-related

Lys_aminomutase-rel

Family

1,309

false

Members of this protein form a distinctive clade, homologous to lysine-2,3-aminomutase (of Bacillus, Clostridium, and methanogenic archaea) and likely similar in function. Members of this family are found in Rhodopseudomonas, Caulobacter vibrioides, Bradyrhizobium, etc.

[]

0

[ "NCBIFAM" ]

[ "TIGR03822" ]

[ "AblA_like_2" ]

[ 1309 ]

1

[]

0

[]

0

[]

0

[ "IPR003739" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 1306, 3 ]

2

[]

0

true

Family

Lysine-2,3-aminomutase-related

Lys_aminomutase-rel

9

IPR022448

22,448

Quinoprotein dehydrogenase-associated

Quinoprotein_dehydrogenase

Family

1,328

false

Proteins in this entry are found in known methanotrophs and a range of PQQ-biosynthesising species. Interpretation of evidence by homology and by direct experimental work suggest two different roles. By homology, these proteins appear to be the periplasmic substrate-binding protein of an ABC transport family. However, ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03871" ]

[ "ABC_peri_MoxJ_2" ]

[ 1328 ]

1

[ "GP" ]

[ "GenProp1101" ]

[ "GP:GenProp1101" ]

1

[ "6onp" ]

1

[ "PUB00085835" ]

[ "3114231" ]

[ "Isolation and nucleotide sequence of the methanol dehydrogenase structural gene from Paracoccus denitrificans." ]

[ 1987 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1316, 2, 10 ]

3

[]

0

true

Family

Quinoprotein dehydrogenase-associated

Quinoprotein_dehydrogenase

6

IPR022450

22,450

tRNA N6-adenosine threonylcarbamoyltransferase, TsaD

TsaD

Family

29,681

false

This entry represents the TsaD protein family that is widely distributed. TsaD and its archaeal homologue Kae1 belong to the Kae1/TsaD family ( ), a conserved protein family with unknown function. This entry includes bacterial TsaD and its homologues, such as Qri7 (localize to the mitochondria) from budding yeast [ ]. ...

[ "GO:0002949" ]

[ "tRNA threonylcarbamoyladenosine modification" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_01445", "TIGR03723" ]

[ "TsaD", "T6A_TsaD_YgjD" ]

[ 29504, 27129 ]

2

[ "EC", "GP", "GP", "GP", "REACTOME" ]

[ "2.3.1.234", "GenProp1060", "GenProp1171", "GenProp1570", "R-HSA-6787450" ]

[ "EC:2.3.1.234", "GP:GenProp1060", "GP:GenProp1171", "GP:GenProp1570", "REACTOME:R-HSA-6787450" ]

5

[ "3wuh", "3zet", "3zeu", "4k25", "4wq4", "4wq5", "4ydu", "6n9a", "6nak", "6nbj", "6s84", "6z81", "8iey", "8ifx" ]

14

[ "PUB00002152", "PUB00035406", "PUB00035445", "PUB00047751", "PUB00059911", "PUB00059913", "PUB00059914", "PUB00059916", "PUB00063355", "PUB00101388" ]

[ "1885539", "16564010", "16874308", "17766251", "21285948", "15837383", "17237169", "19578062", "22378793", "32047918" ]

[ "Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene.", "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.", "Yeast homolog of a cancer-testis antigen defines a new transcription complex.", "An archaeal orthologue ...

[ 1991, 2006, 2006, 2007, 2011, 2005, 2007, 2009, 2012, 2020 ]

10

[ "IPR017861" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Peduoviridae", "unclassified sequences" ]

[ 25935, 3268, 2, 476 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 2, 1, 1, 2, 1, 1, 2, 1, 4, 4, 1, 1, 2 ]

13

true

Family

tRNA N6-adenosine threonylcarbamoyltransferase, TsaD

TsaD

4

IPR022451

22,451

Conserved hypothetical protein CHP03829, YokU

CHP03829_YokU

Family

549

false

Members of this protein family occur in various species of the genus Bacillus, always next to the gene (kamA or ablA) for lysine 2,3-aminomutase. Members have a pair of CXXC motifs, and share homology to the amino-terminal region of a family of putative transcription factors for which the C-terminal is modeled by , a h...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF14122", "TIGR03829" ]

[ "YokU", "YokU_near_AblA" ]

[ 549, 459 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 546, 3 ]

2

[]

0

true

Family

Conserved hypothetical protein CHP03829, YokU

CHP03829_YokU

4

IPR022453

22,453

Zinc finger, MqsA-type

Znf_MqsA-type

Domain

3,011

false

This entry describes a small domain with two copies of a putative zinc-binding motif CXXC (usually CXXCG). Most member proteins consist largely of this domain or else carry an additional C-terminal helix-turn-helix domain, resembling that of the phage protein Cro. This domain is found in Antitoxin MqsA and Uncharacteri...

[]

0

[ "NCBIFAM" ]

[ "TIGR03831" ]

[ "YgiT_finger" ]

[ 3011 ]

1

[]

0

[ "2kz8", "3ga8", "3gn5", "3hi2", "3o9x" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 113, 2791, 7, 9, 91 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Zinc finger, MqsA-type

Znf_MqsA-type

7

IPR022454

22,454

Conserved hypothetical protein CHP03883, F420 biosynthesis associated

CHP03883_F420-assoc

Family

3,793

false

This entry represents proteins found in coenzyme F420 biosynthesizing species of the Actinobacterial, Chloroflexi and Archaeal lineages. The few organisms having genes within this family and lacking F420 biosynthesis may either have an undiscovered F420 transporter, or may represent F420-to-FMN revertants. This family ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03883" ]

[ "DUF2342_F420" ]

[ 3793 ]

1

[ "GP" ]

[ "GenProp0002" ]

[ "GP:GenProp0002" ]

1

[ "3cmn" ]

1

[]

0

[ "IPR018766" ]

[]

1

0

1

[ "Bacteria", "Halobacteriales", "metagenomes" ]

[ 3431, 309, 53 ]

3

[]

0

true

Family

Conserved hypothetical protein CHP03883, F420 biosynthesis associated

CHP03883_F420-assoc

9

IPR022456

22,456

PQQ-dependent catabolism-associated beta-propeller protein

PQQ_b_propeller

Family

1,963

false

Members of this protein family contain a variable number of repeats each of the YVTN family β-propeller repeat. Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.

[]

0

[ "NCBIFAM" ]

[ "TIGR03866" ]

[ "PQQ_ABC_repeats" ]

[ 1963 ]

1

[ "GP" ]

[ "GenProp0895" ]

[ "GP:GenProp0895" ]

1

[]

0

[]

0

[ "IPR019405" ]

[]

1

0

1

[ "Bacteria", "Durusdinium trenchii", "ecological metagenomes" ]

[ 1953, 2, 8 ]

3

[]

0

true

Family

PQQ-dependent catabolism-associated beta-propeller protein

PQQ_b_propeller

7

IPR022457

22,457

Aspartate-alanine antiporter

Asp_Ala_antiprt

Family

1,895

false

This entry represents the aspartate/alanine antiporter and some other uncharacterised transporters. Asparate-alanine anti-transporter (AspT) is encoded next to the gene for aspartate 4-decarboxylase (AspD), which converts asparate to alanine, releasing CO2. The exchange of Asp for Ala is electrogenic, so the AspD/AspT ...

[ "GO:0022857", "GO:0016020" ]

[ "transmembrane transporter activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR03802" ]

[ "Asp_Ala_antiprt" ]

[ 1895 ]

1

[ "GP" ]

[ "GenProp0867" ]

[ "GP:GenProp0867" ]

1

[ "8xw5", "8y1x", "9oqy", "9vdc", "9veb" ]

5

[ "PUB00062345", "PUB00062346", "PUB00062348", "PUB00062349", "PUB00062350" ]

[ "21719707", "19181816", "17660287", "15670744", "17158863" ]

[ "Substrate specificity of the aspartate:alanine antiporter (AspT) of Tetragenococcus halophilus in reconstituted liposomes.", "Structural and functional importance of transmembrane domain 3 (TM3) in the aspartate:alanine antiporter AspT: topology and function of the residues of TM3 and oligomerization of AspT.", ...

[ 2011, 2009, 2007, 2005, 2007 ]

5

[]

0

null

[ "Bacteria" ]

[ 1895 ]

1

[]

0

true

Family

Aspartate-alanine antiporter

Asp_Ala_antiprt

8

IPR022459

22,459

Lysine-2,3-aminomutase

Lysine_aminomutase

Family

1,704

false

This entry describes lysine-2,3-aminomutase as found along with beta-lysine acetyltransferase in a two-enzyme pathway for making the compatible solute N-epsilon-acetyl-beta-lysine. This compatible solute, or osmolyte, is known to protect a number of methanogenic archaea against salt stress. The proteins matched by this...

[]

0

[ "SFLD", "NCBIFAM" ]

[ "SFLDF00283", "TIGR03820" ]

[ "L-lysine_2_3-aminomutase_(LAM-", "lys_2_3_AblA" ]

[ 1692, 1483 ]

2

[ "EC", "GP" ]

[ "5.4.3.2", "GenProp0878" ]

[ "EC:5.4.3.2", "GP:GenProp0878" ]

2

[ "2a5h" ]

1

[]

0

[ "IPR003739" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Carpediemonas membranifera", "ecological metagenomes" ]

[ 108, 1568, 2, 26 ]

4

[]

0

true

Family

Lysine-2,3-aminomutase

Lysine_aminomutase

5

IPR022460

22,460

Conserved hyptotheical flavoprotein, PP4765

Flavoprotein_PP4765

Family

5,130

false

This entry describes a sharply distinctive clade of proteins within the larger family of flavoproteins. Their function is unknown.

[]

0

[ "NCBIFAM" ]

[ "TIGR03862" ]

[ "flavo_PP4765" ]

[ 5130 ]

1

[]

0

[]

0

[]

0

[ "IPR004792" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5085, 8, 37 ]

3

[]

0

true

Family

Conserved hyptotheical flavoprotein, PP4765

Flavoprotein_PP4765

8

IPR022461

22,461

Arginine/ornithine antiporter

Arg/Orn_antiprt_ArcD

Family

2,168

false

This entry represents Arginine/ornithine antiporter from Pseudomonas aeruginosa and similar bacterial proteins. ArcD catalyses an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway [ ]. This exchanger occurs with the generation of ATP and ...

[ "GO:0043858", "GO:0006527", "GO:1903826", "GO:0005886" ]

[ "arginine:ornithine antiporter activity", "L-arginine catabolic process", "L-arginine transmembrane transport", "plasma membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR03810" ]

[ "arg_ornith_anti" ]

[ 2168 ]

1

[ "GP" ]

[ "GenProp0639" ]

[ "GP:GenProp0639" ]

1

[]

0

[ "PUB00100061" ]

[ "1311296" ]

[ "arcD, the first gene of the arc operon for anaerobic arginine catabolism in Pseudomonas aeruginosa, encodes an arginine-ornithine exchanger." ]

[ 1992 ]

1

[ "IPR004754" ]

[]

1

0

1

[ "Bacteria", "leotiomyceta", "metagenomes" ]

[ 2164, 2, 2 ]

3

[]

0

true

Family

Arginine/ornithine antiporter

Arg/Orn_antiprt_ArcD

8

IPR022462

22,462

Lysine-2,3-aminomutase-like

EpmB

Family

4,221

false

Members of this radical SAM protein subfamily, including yjeK in E. coli, form a distinctive clade, homologous to lysine-2,3-aminomutase of Bacillus, Clostridium, and methanogenic archaea. Members of this family are found in E. coli, Buchnera, Yersinia, etc. The gene symbol is now reassigned as EpmB (Elongation factor ...

[]

0

[ "SFLD", "NCBIFAM" ]

[ "SFLDF00314", "TIGR03821" ]

[ "L-lysine_2_3-aminomutase_(yjeK", "EFP_modif_epmB" ]

[ 4191, 4180 ]

2

[ "EC", "GP", "METACYC" ]

[ "5.4.3.-", "GenProp0988", "PWY-7570" ]

[ "EC:5.4.3.-", "GP:GenProp0988", "METACYC:PWY-7570" ]

3

[]

0

[ "PUB00074048" ]

[ "22128152" ]

[ "Post-translational modification by β-lysylation is required for activity of Escherichia coli elongation factor P (EF-P)." ]

[ 2012 ]

1

[ "IPR003739" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4171, 4, 46 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Lysine-2,3-aminomutase-like

EpmB

8

IPR022463

22,463

Fructose 1-phosphate kinase

1-PFruKinase

Family

10,179

false

Fructose 1-phosphate kinase (also known as 1-phosphofructokinase) acts in concert with the fructose-specific phosphotransferase system (PTS), which phosphorylates fructose during transport to fructose-1-phosphate. The action of 1-phosphofructokinase results in beta-D-fructose-1,6-bisphosphate and is an entry point into...

[ "GO:0008662" ]

[ "1-phosphofructokinase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03828" ]

[ "pfkB" ]

[ 10179 ]

1

[ "EC", "GP" ]

[ "2.7.1.56", "GenProp0693" ]

[ "EC:2.7.1.56", "GP:GenProp0693" ]

2

[ "2abq", "2jg5" ]

2

[ "PUB00060540" ]

[ "22493022" ]

[ "Fructose degradation in the haloarchaeon Haloferax volcanii involves a bacterial type phosphoenolpyruvate-dependent phosphotransferase system, fructose-1-phosphate kinase, and class II fructose-1,6-bisphosphate aldolase." ]

[ 2012 ]

1

[ "IPR017583" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 10126, 4, 32, 17 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Fructose 1-phosphate kinase

1-PFruKinase

5

IPR022464

22,464

Streptococcal pilin isopeptide linkage domain

Strep_pil_isopept_link

Domain

1,807

false

This entry describes a domain that occurs once in the major pilin of Streptococcus pyogenes, Spy0128, but in higher copy numbers in other streptococcal and related bacteria proteins. The domain occurs nine times in a surface-anchored protein of Bifidobacterium longum. All members of this family have LPXTG-type sortase ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF12892", "TIGR03786" ]

[ "FctA", "strep_pil_rpt" ]

[ 1698, 1505 ]

2

[]

0

[ "3b2m", "3gld", "3gle", "3klq", "5ttd", "6bbt", "6bbw", "6n0a", "7f7y", "8f5n", "8f70", "8k6t" ]

12

[ "PUB00056245" ]

[ "19497855" ]

[ "Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Culter alburnus", "unclassified sequences" ]

[ 1801, 2, 4 ]

3

[]

0

true

Domain

Streptococcal pilin isopeptide linkage domain

Strep_pil_isopept_link

5

IPR022465

22,465

Terminal organelle assembly protein TopJ

Termin_org_TopJ

Family

8

false

This entry describes TopJ (MG_200, CbpA), a DnaJ homologue and probable assembly protein of the Mycoplasma terminal organelle. The terminal organelle is involved in both cytadherence and gliding motility [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR03835" ]

[ "termin_org_DnaJ" ]

[ 8 ]

1

[]

0

[]

0

[ "PUB00062401" ]

[ "19183275" ]

[ "Mycoplasma pneumoniae J-domain protein required for terminal organelle function." ]

[ 2009 ]

1

[]

0

null

[ "Mycoplasmoides" ]

[ 8 ]

1

[]

0

true

Family

Terminal organelle assembly protein TopJ

Termin_org_TopJ

7

IPR022466

22,466

Enriched in aromatic and glycine residues box

EAGR_box

Domain

46

false

The EAGR box, Enriched in Aromatic and Glycine Residues, is found in three different proteins of the Mycoplasma genitalium terminal organelle, which acts in both cytadherence and gliding motility. The presence of this domain in a genome predicts the Mycoplasma-type terminal organelle structure, gliding motility, and cy...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF16713", "TIGR03834" ]

[ "EAGR_box", "EAGR_box" ]

[ 46, 41 ]

2

[]

0

[ "4dcz" ]

1

[ "PUB00088228" ]

[ "22925012" ]

[ "The EAGR box structure: a motif involved in mycoplasma motility." ]

[ 2012 ]

1

[]

0

null

[ "Mycoplasmatota" ]

[ 46 ]

1

[]

0

true

Domain

Enriched in aromatic and glycine residues box

EAGR_box

2

IPR022467

22,467

ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system

ABC_transprt_ATP-bd_su_PQQ

Family

1,621

false

Members of this protein family are the ATP-binding subunit of an ABC transporter system that is associated with PQQ biosynthesis and PQQ-dependent alcohol dehydrogenases. While this family shows homology to several efflux ABC transporter subunits, the presence of a periplasmic substrate-binding protein and association ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03864" ]

[ "PQQ_ABC_ATP" ]

[ 1621 ]

1

[ "GP" ]

[ "GenProp0895" ]

[ "GP:GenProp0895" ]

1

[]

0

[]

0

[]

0

null

[ "Pseudomonadota", "ecological metagenomes" ]

[ 1612, 9 ]

2

[]

0

true

Family

ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system

ABC_transprt_ATP-bd_su_PQQ

6

IPR022468

22,468

Phosphonatase-like hydrolase

PhnX-like

Family

1,437

false

This clade of sequences are the closest homologues to the PhnX enzyme, phosphonoacetaldehyde (Pald) hydrolase (phosphonatase, ). This phosphonatase-like enzyme and PhnX itself are members of the haloacid dehalogenase (HAD) superfamily having a a number of distinctive features that set them apart from typical HAD enzyme...

[]

0

[ "NCBIFAM" ]

[ "TIGR03351" ]

[ "PhnX-like" ]

[ 1437 ]

1

[ "GP" ]

[ "GenProp0736" ]

[ "GP:GenProp0736" ]

1

[]

0

[ "PUB00042854", "PUB00042855" ]

[ "17070898", "17123828" ]

[ "Diversification of function in the haloacid dehalogenase enzyme superfamily: The role of the cap domain in hydrolytic phosphoruscarbon bond cleavage.", "Detection and identification of Bacteriovorax stolpii UKi2 Sphingophosphonolipid molecular species." ]

[ 2006, 2007 ]

2

[]

0

null

[ "Bacteria", "Durusdinium trenchii" ]

[ 1435, 2 ]

2

[]

0

true

Family

Phosphonatase-like hydrolase

PhnX-like

8

IPR022469

22,469

6-pyruvoyl tetrahydropterin synthase, histidine active site

PTPS_His_AS

Active_site

1,396

false

6-pyruvoyl tetrahydropterin synthase ( ) (PTPS) [ ] catalyzes the second step in the biosynthesis of tetrahydrobiopterin (BH4); a complex rearrangement of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. PTPS is a small protein of about 145 residues and forms a homooligomeric complex of two trimers a...

[ "GO:0003874", "GO:0006729" ]

[ "6-pyruvoyltetrahydropterin synthase activity", "tetrahydrobiopterin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PROSITE" ]

[ "PS00988" ]

[ "PTPS_2" ]

[ 1396 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.2.3.12", "PWY-5663", "PWY-6983", "PWY-7442", "R-DME-1474151", "R-HSA-1474151", "R-MMU-1474151", "R-RNO-1474151" ]

[ "EC:4.2.3.12", "METACYC:PWY-5663", "METACYC:PWY-6983", "METACYC:PWY-7442", "REACTOME:R-DME-1474151", "REACTOME:R-HSA-1474151", "REACTOME:R-MMU-1474151", "REACTOME:R-RNO-1474151" ]

8

[ "1b66", "1b6z", "1gtq", "3i2b" ]

4

[ "PUB00001245" ]

[ "8137809" ]

[ "Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis." ]

[ 1994 ]

1

[]

0

null

[ "Eukaryota", "Pseudovibrio axinellae" ]

[ 1395, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 5, 2, 7 ]

5

true

Active_site

6-pyruvoyl tetrahydropterin synthase, histidine active site

PTPS_His_AS

3

IPR022470

22,470

6-pyruvoyl tetrahydropterin synthase, cysteine active site

PTPS_Cys_AS

Active_site

1,577

false

6-pyruvoyl tetrahydropterin synthase ( ) (PTPS) [ ] catalyzes the second step in the biosynthesis of tetrahydrobiopterin (BH4); a complex rearrangement of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. PTPS is a small protein of about 145 residues and forms a homooligomeric complex of two trimers a...

[ "GO:0003874", "GO:0006729" ]

[ "6-pyruvoyltetrahydropterin synthase activity", "tetrahydrobiopterin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PROSITE" ]

[ "PS00987" ]

[ "PTPS_1" ]

[ 1577 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.2.3.12", "PWY-5663", "PWY-6983", "PWY-7442", "R-CEL-1474151", "R-DME-1474151", "R-HSA-1474151", "R-MMU-1474151", "R-RNO-1474151" ]

[ "EC:4.2.3.12", "METACYC:PWY-5663", "METACYC:PWY-6983", "METACYC:PWY-7442", "REACTOME:R-CEL-1474151", "REACTOME:R-DME-1474151", "REACTOME:R-HSA-1474151", "REACTOME:R-MMU-1474151", "REACTOME:R-RNO-1474151" ]

9

[ "1b66", "1b6z", "1gtq", "2g64", "3i2b" ]

5

[ "PUB00001245" ]

[ "8137809" ]

[ "Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 165, 1399, 13 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 6, 1, 5 ]

6

true

Active_site

6-pyruvoyl tetrahydropterin synthase, cysteine active site

PTPS_Cys_AS

5

IPR022471

22,471

Cysteine desulphurase, catalytic subunit, CsdA

Cys_desulphurase_CdsA

Family

1,878

false

In Escherichia coli, three cysteine desulfurases (IscS, SufS, and CsdA) initiate the delivery of sulfur for various biological processes such as the biogenesis of Fe-S clusters. CsdA is part of the Csd system. This protein, found in Escherichia coli, Yersinia pestis, Photorhabdus luminescens, and related species, is re...

[ "GO:0031071", "GO:0016226" ]

[ "cysteine desulfurase activity", "iron-sulfur cluster assembly" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03392" ]

[ "FeS_syn_CsdA" ]

[ 1878 ]

1

[ "GP", "GP" ]

[ "GenProp0739", "GenProp1174" ]

[ "GP:GenProp0739", "GP:GenProp1174" ]

2

[ "4lw2", "4lw4", "5ft4", "5ft5", "5ft6", "5ft8" ]

6

[ "PUB00043102", "PUB00078775" ]

[ "15901727", "23913692" ]

[ "Analysis of the heteromeric CsdA-CsdE cysteine desulfurase, assisting Fe-S cluster biogenesis in Escherichia coli.", "Structural changes during cysteine desulfurase CsdA and sulfur acceptor CsdE interactions provide insight into the trans-persulfuration." ]

[ 2005, 2013 ]

2

[ "IPR010970" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 1875, 3 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cysteine desulphurase, catalytic subunit, CsdA

Cys_desulphurase_CdsA

5

IPR022472

22,472

VPLPA-CTERM sorting domain

VPLPA-CTERM

Domain

1,869

false

A probable protein export sorting signal, PEP-CTERM, has been described previously [ ]. It is predicted to interact with a putative transpeptidase we designate exosortase. This entry describes a variant with conserved motif VPLPA, rather than VPEP. It appears to be the recognition sequences for exosortase D. This varia...

[]

0

[ "NCBIFAM" ]

[ "TIGR03370" ]

[ "VPLPA-CTERM" ]

[ 1869 ]

1

[]

0

[]

0

[ "PUB00034422", "PUB00060405" ]

[ "16930487", "22037399" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.", "Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification." ]

[ 2006, 2012 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1799, 8, 62 ]

3

[]

0

true

Domain

VPLPA-CTERM sorting domain

VPLPA-CTERM

5

IPR022473

22,473

ABC transporter, Choline, ATP-binding subunit

ABC_trnsptr_Choline_ATP-bd

Family

2,250

false

Members of this protein family are the ATP-binding subunit of a three-protein transporter. This family belongs, more broadly, to the family of proline and glycine-betaine transporters, but members have been identified by direct characterisation and by bioinformatic means as choline transporters. Many species have sever...

[ "GO:0015220", "GO:0015871", "GO:0055052" ]

[ "choline transmembrane transporter activity", "choline transport", "ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR03415" ]

[ "ABC_choXWV_ATP" ]

[ 2250 ]

1

[ "GP" ]

[ "GenProp0748" ]

[ "GP:GenProp0748" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Effrenium voratum", "ecological metagenomes" ]

[ 2244, 1, 5 ]

3

[]

0

true

Family

ABC transporter, Choline, ATP-binding subunit

ABC_trnsptr_Choline_ATP-bd

6

IPR022474

22,474

Thiopurine S-methyltransferase, Se/Te detoxification

Thiopur_S-MeTfrase_Se/Te_detox

Family

2,706

false

Members of this family are thiopurine S-methyltransferase from a branch in which at least some member proteins can perform selenium methylation as a means to detoxify selenium, or perform a related detoxification of tellurium [ , ]. Note that the EC number definition does not specify a particular thiopurine, but rather...

[ "GO:0008119", "GO:0010038", "GO:0032259" ]

[ "thiopurine S-methyltransferase activity", "response to metal ion", "methylation" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR03840" ]

[ "TMPT_Se_Te" ]

[ 2706 ]

1

[ "EC" ]

[ "2.1.1.67" ]

[ "EC:2.1.1.67" ]

1

[ "1pjz" ]

1

[ "PUB00056781", "PUB00058177" ]

[ "9565678", "15658983" ]

[ "A tellurite-resistance genetic determinant from phytopathogenic pseudomonads encodes a thiopurine methyltransferase: evidence of a widely-conserved family of methyltransferases.", "Freshwater selenium-methylating bacterial thiopurine methyltransferases: diversity and molecular phylogeny." ]

[ 1998, 2005 ]

2

[ "IPR025835" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2662, 3, 41 ]

3

[]

0

true

Family

Thiopurine S-methyltransferase, Se/Te detoxification

Thiopur_S-MeTfrase_Se/Te_detox

6

IPR022475

22,475

Uncharacterised protein family UPF0273, KaiC-like

UPF0273_KaiC-like

Family

158

false

Members of this family contain a single copy of the KaiC domain that occurs in two copies of the circadian clock protein kinase KaiC itself. Members occur primarily in archaea and in Thermotogales.

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01076", "TIGR03877" ]

[ "UPF0273", "thermo_KaiC_1" ]

[ 156, 158 ]

2

[]

0

[ "2dr3" ]

1

[]

0

[]

0

null

[ "Archaea", "Thermotogales" ]

[ 150, 8 ]

2

[]

0

true

Family

Uncharacterised protein family UPF0273, KaiC-like

UPF0273_KaiC-like

6

IPR022476

22,476

Spore protein YabP/YqfC

Spore_YabP/YqfC

Family

4,969

false

Members of this protein family are the YabP and YqfC proteins of the bacterial sporulation program, as found in Bacillus subtilis, Clostridium tetani, and other spore-forming members of the Firmicutes. The structure of a fragment of the Spore protein YabP from Desulfitobacterium hafniense has been resolved using NMR sp...

[]

0

[ "PFAM" ]

[ "PF07873" ]

[ "YabP" ]

[ 4969 ]

1

[]

0

[ "2ks0", "2kyi", "3ipf" ]

3

[ "PUB00099797" ]

[ "21904870" ]

[ "Solution NMR structure of Dsy0195 homodimer from Desulfitobacterium hafniense: first structure representative of the YabP domain family of proteins involved in spore coat assembly." ]

[ 2011 ]

1

[]

[ "IPR012504", "IPR022477" ]

0

2

0

[ "Bacteria", "Phytophthora kernoviae 00238/432", "Siphoviridae sp. ctjdk2", "metagenomes" ]

[ 4920, 1, 1, 47 ]

4

[]

0

true

Family

Spore protein YabP/YqfC

Spore_YabP/YqfC

1

IPR022477

22,477

Sporulation protein YqfC

Spore_YqfC

Family

1,672

false

This small protein, designated YqfC in Bacillus subtilis, is both restricted to and universal in sporulating species of the Firmcutes, such as Bacillus subtilis and Clostridium perfringens. It is part of the sigma(E)-controlled regulon, and its mutation leads to a sporulation defect [ ]. This protein is uncharacterised...

[]

0

[ "NCBIFAM" ]

[ "TIGR02856" ]

[ "spore_yqfC" ]

[ 1672 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[ "PUB00012907" ]

[ "12662922" ]

[ "The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis." ]

[ 2003 ]

1

[ "IPR022476" ]

[]

1

0

1

[ "Bacillota", "Phytophthora kernoviae 00238/432", "ecological metagenomes" ]

[ 1663, 1, 8 ]

3

[]

0

true

Family

Sporulation protein YqfC

Spore_YqfC

4

IPR022478

22,478

ABC transporter, substrate-binding protein, PQQ-dependent alcohol dehydrogenase system

ABC_transptr_sub-bd_PQQ

Family

1,708

false

Members of this protein family are putative substrate-binding proteins of an ABC transporter family that associates, in gene neighbourhood and phylogenomic profile, with pyrroloquinoline-quinone (PQQ)-dependent degradation of certain alcohols, such as 2-phenylethanol in Pseudomonas putida U.

[]

0

[ "NCBIFAM" ]

[ "TIGR03863" ]

[ "PQQ_ABC_bind" ]

[ 1708 ]

1

[ "GP" ]

[ "GenProp0895" ]

[ "GP:GenProp0895" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Durusdinium trenchii", "ecological metagenomes" ]

[ 1701, 2, 5 ]

3

[]

0

true

Family

ABC transporter, substrate-binding protein, PQQ-dependent alcohol dehydrogenase system

ABC_transptr_sub-bd_PQQ

7

IPR022479

22,479

Coenzyme PQQ synthesis D, bacteria

PqqD_bac

Family

4,114

false

This entry identifies PqqD, a protein involved in the final steps of the biosynthesis of pyrroloquinoline quinone, coenzyme PQQ [ ].

[ "GO:0048038", "GO:0018189" ]

[ "quinone binding", "pyrroloquinoline quinone biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00655", "TIGR03859" ]

[ "PQQ_syn_PqqD", "PQQ_PqqD" ]

[ 1797, 4114 ]

2

[ "GP" ]

[ "GenProp0170" ]

[ "GP:GenProp0170" ]

1

[ "3g2b", "5sxy", "5vrd" ]

3

[ "PUB00053708" ]

[ "17223081" ]

[ "Factors required for the catalytic reaction of PqqC/D which produces pyrroloquinoline quinone." ]

[ 2007 ]

1

[ "IPR008792" ]

[]

1

0

1

[ "Acidianus ambivalens", "Bacteria", "Geodia barretti", "metagenomes" ]

[ 1, 4092, 1, 20 ]

4

[]

0

true

Family

Coenzyme PQQ synthesis D, bacteria

PqqD_bac

8

IPR022480

22,480

F420-dependent oxidoreductase, MSMEG2906

F420_MSMEG2906

Family

1,803

false

This entry describes a small family of enzymes in the bacterial luciferase-like monooxygenase family, which includes F420-dependent enzymes such as N5,N10-methylenetetrahydromethanopterin reductase as well as FMN-dependent enzymes. All members of this family are from species that produce coenzyme F420; SIMBAL analysis ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03856" ]

[ "F420_MSMEG_2906" ]

[ 1803 ]

1

[ "GP" ]

[ "GenProp0002" ]

[ "GP:GenProp0002" ]

1

[]

0

[]

0

[ "IPR050172" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 1780, 23 ]

2

[]

0

true

Family

F420-dependent oxidoreductase, MSMEG2906

F420_MSMEG2906

2

IPR022481

22,481

Large ribosomal subunit protein eL8, archaea

Ribosomal_eL8_arc

Family

899

false

This entry specifically identifies the archaeal version of the large ribosomal complex eL8 protein, previously designated L7Ae. These are multifunctional RNA-binding proteins that recognises the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs [ ]. It interacts with protein L15e. Ribosomes are the ...

[ "GO:0003723", "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "RNA binding", "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "HAMAP", "NCBIFAM" ]

[ "MF_00326", "TIGR03677" ]

[ "Ribosomal_eL8", "eL8_ribo" ]

[ 881, 899 ]

2

[]

0

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1pxw", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1ra4", "1rlg", "1s72", "1sds", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm"...

161

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00037490" ]

[ "11297922", "11290319", "11114498", "16008351" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "The crystal structure of the Methanocaldococcus jannaschii multifunctional L7Ae RNA-binding protein reveals an induced-fit interaction with the box C/D RNAs." ]

[ 2001, 2001, 2000, 2005 ]

4

[ "IPR018492" ]

[]

1

0

1

[ "Archaea", "Geodia barretti", "ecological metagenomes" ]

[ 876, 1, 22 ]

3

[]

0

true

Family

Large ribosomal subunit protein eL8, archaea

Ribosomal_eL8_arc

6

IPR022482

22,482

Proteasome ATPase

Proteasome_ATPase

Family

4,072

false

In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an ε-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacte...

[ "GO:0016887", "GO:0010498", "GO:0019941", "GO:0000502" ]

[ "ATP hydrolysis activity", "proteasomal protein catabolic process", "modification-dependent protein catabolic process", "proteasome complex" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "HAMAP", "NCBIFAM" ]

[ "MF_02112", "TIGR03689" ]

[ "ARC_ATPase", "pup_AAA" ]

[ 3825, 4069 ]

2

[ "GP" ]

[ "GenProp0833" ]

[ "GP:GenProp0833" ]

1

[ "5kwa", "5kzf", "7ljf", "7px9", "7pxa", "7pxb", "7pxc", "7pxd", "8d6x", "8d6y" ]

10

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3995, 3, 74 ]

3

[]

0

true

Family

Proteasome ATPase

Proteasome_ATPase

6

IPR022483

22,483

Proteasome subunit beta, actinobacteria

PSB_actinobac

Family

3,603

false

Threonine peptidases are characterised by a threonine nucleophile at the N terminus of the mature enzyme. The threonine peptidases belong to clan PB or are unassigned, clan T-. The type example for this clan is the archaean proteasome beta component of Thermoplasma acidophilum. This entry represents Proteasome subunit ...

[ "GO:0004298", "GO:0010498", "GO:0005839" ]

[ "threonine-type endopeptidase activity", "proteasomal protein catabolic process", "proteasome core complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_02113_B", "TIGR03690" ]

[ "Proteasome_B_B", "20S_bact_beta" ]

[ 3292, 3602 ]

2

[ "EC", "GP" ]

[ "3.4.25.1", "GenProp0834" ]

[ "EC:3.4.25.1", "GP:GenProp0834" ]

2

[ "1q5q", "1q5r", "2fhg", "2fhh", "2h6j", "2jay", "3h6f", "3h6i", "3hf9", "3hfa", "3krd", "3mfe", "3mi0", "3mka", "5lzp", "5tho", "5trg", "5trr", "5trs", "5try", "5ts0", "6bgl", "6bgo", "6ocw", "6ocz", "6ode", "6wnk", "7pxa", "7pxc", "7pxd", "8d6v", "8d6w"...

40

[ "PUB00014621", "PUB00100063", "PUB00100064", "PUB00100065", "PUB00100066", "PUB00100067", "PUB00100068" ]

[ "9765579", "20711362", "33468462", "34179091", "18059281", "17082771", "16468985" ]

[ "The 20S proteasome of Streptomyces coelicolor.", "The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.", "The Pup-Proteasome System Protects Mycobacteria from Antimicrobial Antifolates.", "Survival in Host...

[ 1998, 2010, 2021, 2021, 2007, 2006, 2006 ]

7

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3534, 69 ]

2

[]

0

true

Family

Proteasome subunit beta, actinobacteria

PSB_actinobac

6

IPR022484

22,484

PEP-CTERM/exosortase system-associated acyltransferase, predicted

PEP-CTERM/exosrtase_acylTfrase

Family

844

false

Members of this protein family are restricted to bacterial species with the PEP-CTERM/exosortase system predicted to act in exopolysaccharide-associated protein targeting [ ]. Different sequence analysis methodologies reveal relationships to the acyltransferase family that includes N-acyl-L-homoserine lactone synthetas...

[]

0

[ "NCBIFAM" ]

[ "TIGR03694" ]

[ "exosort_acyl" ]

[ 844 ]

1

[]

0

[]

0

[ "PUB00034422" ]

[ "16930487" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Palpitomonas bilix", "ecological metagenomes" ]

[ 833, 2, 9 ]

3

[]

0

true

Family

PEP-CTERM/exosortase system-associated acyltransferase, predicted

PEP-CTERM/exosrtase_acylTfrase

5

IPR022485

22,485

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

SHCHC_synthase_MenH

Family

4,710

false

This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) [ ]. Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC sy...

[ "GO:0070205", "GO:0009234" ]

[ "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity", "menaquinone biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01660", "TIGR03695" ]

[ "MenH", "menH_SHCHC" ]

[ 4622, 4430 ]

2

[ "EC", "GP", "GP", "METACYC" ]

[ "4.2.99.20", "GenProp0058", "GenProp1560", "PWY-5837" ]

[ "EC:4.2.99.20", "GP:GenProp0058", "GP:GenProp1560", "METACYC:PWY-5837" ]

4

[ "1r3d", "2xmz", "4gdm", "4gec", "4geg", "4mxd", "4myd", "4mys" ]

8

[ "PUB00057514" ]

[ "18284213" ]

[ "Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4320, 358, 32 ]

3

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 1, 2, 1 ]

3

true

Family

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

SHCHC_synthase_MenH

2

IPR022486

22,486

Polyphosphate kinase 2, PA0141

PPK2_PA0141

Family

12,390

false

Members of this protein family are designated polyphosphate kinase 2 (PPK2) after the characterised protein in Pseudomonas aeruginosa [ ]. This family comprises one of three well-separated clades in the larger family described by Pfam model . GDP-polyphosphate phosphotransferase, also known as Polyphosphate kinase PPK2...

[ "GO:0008976", "GO:0006793" ]

[ "polyphosphate kinase activity", "phosphorus metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03707" ]

[ "PPK2_P_aer" ]

[ 12390 ]

1

[ "EC", "GP", "METACYC", "METACYC" ]

[ "2.7.4.-", "GenProp0840", "PWY-5107", "PWY-7039" ]

[ "EC:2.7.4.-", "GP:GenProp0840", "METACYC:PWY-5107", "METACYC:PWY-7039" ]

4

[ "3czq", "4yeg", "5ll0", "5llb", "5llf", "6dzg" ]

6

[ "PUB00020170" ]

[ "12482933" ]

[ "Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes", "uncultured marine phage" ]

[ 12192, 29, 50, 118, 1 ]

5

[]

0

true

Family

Polyphosphate kinase 2, PA0141

PPK2_PA0141

1

IPR022487

22,487

L-aspartate dehydrogenase, archaeal

Asp_DH_arc

Family

615

false

This entry represents L-aspartate dehydrogenase, as shown for the NADP-dependent enzyme TM_1643 of Thermotoga maritima. Members lack homology to NadB, the aspartate oxidase ( ) of most mesophilic bacteria (described by ), which this enzyme replaces in the generation of oxaloacetate from aspartate for the NAD biosynthet...

[ "GO:0033735" ]

[ "aspartate dehydrogenase [NAD(P)+] activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03855" ]

[ "NAD_NadX" ]

[ 615 ]

1

[ "EC", "GP" ]

[ "1.4.1.21", "GenProp0057" ]

[ "EC:1.4.1.21", "GP:GenProp0057" ]

2

[ "1h2h", "1j5p", "2dc1" ]

3

[]

0

[ "IPR020626" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Geodia barretti", "ecological metagenomes" ]

[ 344, 257, 1, 13 ]

4

[]

0

true

Family

L-aspartate dehydrogenase, archaeal

Asp_DH_arc

5

IPR022488

22,488

Polyphosphate kinase-2-related

PPK2-related

Domain

24,516

false

Inorganic polyphosphate (polyP) plays a role in metabolism and regulation and has been proposed to serve as a energy source in a pre-ATP world. In prokaryotes, the synthesis and utilisation of polyP are catalysed by PPK1, PPK2 and polyphosphatases. PPK2s can be subdivided into three classes: class I preferentially phos...

[]

0

[ "PFAM" ]

[ "PF03976" ]

[ "PPK2" ]

[ 24516 ]

1

[ "EC", "GP", "METACYC", "METACYC" ]

[ "2.7.4.-", "GenProp0840", "PWY-5107", "PWY-7039" ]

[ "EC:2.7.4.-", "GP:GenProp0840", "METACYC:PWY-5107", "METACYC:PWY-7039" ]

4

[ "3czp", "3czq", "3rhf", "4yeg", "5lc9", "5lcd", "5ld1", "5ldb", "5ll0", "5llb", "5llf", "5maq", "5o6k", "5o6m", "6an9", "6ang", "6anh", "6aqe", "6aqn", "6au0", "6b18", "6dzg", "7bmm", "7nmj", "7plj", "9gia", "9gp9", "9h8j", "9h8k", "9h8l", "9igq", "9igr"...

32

[ "PUB00020169", "PUB00020170", "PUB00051190", "PUB00099676" ]

[ "12486232", "12482933", "19001261", "29531036" ]

[ "A polyphosphate kinase (PPK2) widely conserved in bacteria.", "Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP.", "Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria.", "Substrate recognition and mechanism revealed by ligand-bound p...

[ 2002, 2002, 2008, 2018 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 165, 23960, 78, 2, 311 ]

5

[]

0

true

Domain

Polyphosphate kinase-2-related

PPK2-related

4

IPR022490

22,490

Protein translocase subunit SecA2

SecA2

Family

698

false

Members of this protein family are homologous to SecA and part of the accessory Sec system. This system, including both five core proteins for export and a variable number of proteins for glycosylation, operates in certain Gram-positive pathogens for the maturation and delivery of serine-rich glycoproteins such as the ...

[ "GO:0015450", "GO:0015031" ]

[ "protein-transporting ATPase activity", "protein transport" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03714" ]

[ "secA2" ]

[ 698 ]

1

[ "EC" ]

[ "7.4.2.8" ]

[ "EC:7.4.2.8" ]

1

[]

0

[ "PUB00070738", "PUB00070739" ]

[ "12010500", "23000954" ]

[ "An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets.", "Emerging themes in SecA2-mediated protein export." ]

[ 2002, 2012 ]

2

[ "IPR000185" ]

[]

1

0

1

[ "Bacillati", "human gut metagenome" ]

[ 697, 1 ]

2

[]

0

true

Family

Protein translocase subunit SecA2

SecA2

5

IPR022492

22,492

Phosphomutase MSMEG4193, putative

Phosphomutase_MSMEG4193_put

Family

3,370

false

This entry represents a three-gene system broadly conserved among the Actinobacteria which includes MSMEG_4193 and homologues. Another member of the trio is a probable kinase, related to phosphatidylinositol kinases; that context supports the hypothesis that this protein acts as a phosphomutase.

[]

0

[ "NCBIFAM" ]

[ "TIGR03848" ]

[ "MSMEG_4193" ]

[ 3370 ]

1

[ "GP" ]

[ "GenProp0894" ]

[ "GP:GenProp0894" ]

1

[]

0

[]

0

[ "IPR013078" ]

[]

1

0

1

[ "Bacillati", "metagenomes" ]

[ 3253, 117 ]

2

[]

0

true

Family

Phosphomutase MSMEG4193, putative

Phosphomutase_MSMEG4193_put

4

IPR022493

22,493

Integral membrane YkoY

CHP03716_TM_YkoY

Family

3,990

false

This entry represents a group of proteins that are commonly preceded by a structured RNA element called the yybP-ykoY leader, or SraF, which may precede one or several genes in a genome. Members of this highly hydrophobic protein family often are preceded by a yybP-ykoY leader, which may serve as a riboswitch. From the...

[]

0

[ "NCBIFAM" ]

[ "TIGR03716" ]

[ "R_switched_YkoY" ]

[ 3990 ]

1

[]

0

[]

0

[ "PUB00053669" ]

[ "15096624" ]

[ "New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control." ]

[ 2004 ]

1

[ "IPR005496" ]

[]

1

0

1

[ "Bacteria", "Sar", "Siminovitchvirus", "metagenomes" ]

[ 3975, 7, 3, 5 ]

4

[]

0

true

Family

Integral membrane YkoY

CHP03716_TM_YkoY

8

IPR022494

22,494

Sulfopyruvate decarboxylase, beta subunit

Sulfopyruvate_deCO2ase_bsu

Domain

646

false

Nearly every member of this entry is the beta subunit, or else the C-terminal region, of sulfopyruvate decarboxylase, in an archaeal species capable of coenzyme M biosynthesis. However, the enzyme also occurs in Roseovarius nubinhibens ISM in a degradative pathway, where the resulting sulfoacetaldehyde is desulfonated ...

[ "GO:0003824", "GO:0030976" ]

[ "catalytic activity", "thiamine pyrophosphate binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR03846", "cd03372" ]

[ "sulfopy_beta", "TPP_ComE" ]

[ 381, 626 ]

2

[ "EC", "GP", "METACYC", "METACYC" ]

[ "4.1.1.79", "GenProp0891", "PWY-6637", "PWY-6643" ]

[ "EC:4.1.1.79", "GP:GenProp0891", "METACYC:PWY-6637", "METACYC:PWY-6643" ]

4

[]

0

[ "PUB00010733", "PUB00053709" ]

[ "10940029", "19581363" ]

[ "Identification of the gene encoding sulfopyruvate decarboxylase, an enzyme involved in biosynthesis of coenzyme M.", "Bifurcated degradative pathway of 3-sulfolactate in Roseovarius nubinhibens ISM via sulfoacetaldehyde acetyltransferase and (S)-cysteate sulfolyase." ]

[ 2000, 2009 ]

2

[ "IPR011766" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriati", "ecological metagenomes" ]

[ 417, 213, 16 ]

3

[]

0

true

Domain

Sulfopyruvate decarboxylase, beta subunit

Sulfopyruvate_deCO2ase_bsu

9

IPR022495

22,495

Serine/threonine-protein kinase Bud32

Bud32

Family

4,202

false

Serine/threonine-protein kinase Bud32 is conserved from Archaea to human. In many Archaeal genomes, Kae1 and Bud32 are fused [ ]. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex (composed of Bud32, Kae1, Cgi121, Pcc1 and Gon7), an apparently ancient protein kinase-containing mol...

[ "GO:0004674" ]

[ "protein serine/threonine kinase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03724" ]

[ "arch_bud32" ]

[ 4202 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-HSA-6782315", "R-HSA-6804756", "R-MMU-6804756" ]

[ "EC:2.7.11.1", "REACTOME:R-HSA-6782315", "REACTOME:R-HSA-6804756", "REACTOME:R-MMU-6804756" ]

4

[ "2vwb", "3en9", "3enh", "4ww5", "4ww7", "4ww9", "4wwa", "6wqx", "7sza", "7szb", "7szc", "7szd", "8k20", "8unk", "8up5", "9d85" ]

16

[ "PUB00059772", "PUB00059910", "PUB00060558", "PUB00106776" ]

[ "19172740", "21183954", "19143597", "34614169" ]

[ "Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex.", "The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.", "The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably ...

[ 2008, 2011, 2009, 2021 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 940, 3, 3231, 28 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 6, 1, 1, 1, 2, 3, 3, 4, 1, 1, 4 ]

11

true

Family

Serine/threonine-protein kinase Bud32

Bud32

4

IPR022496

22,496

tRNA threonylcarbamoyl adenosine modification protein TsaB

T6A_TsaB

Family

25,012

false

TsaB, previously known as YeaZ, has been shown to be involved in N6-threonylcarbamoyladenonsine (t(6)A) biosynthesis, together with YgjD (TsaD), YrdC (TsaC), and YjeE (TsaE) [ , ].

[ "GO:0002949" ]

[ "tRNA threonylcarbamoyladenosine modification" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR03725" ]

[ "T6A_YeaZ" ]

[ 25012 ]

1

[ "GP", "GP", "GP" ]

[ "GenProp1060", "GenProp1171", "GenProp1570" ]

[ "GP:GenProp1060", "GP:GenProp1171", "GP:GenProp1570" ]

3

[ "1okj", "2a6a", "2gel", "2gem", "3r6m", "3zet", "3zeu", "4wq4", "4wq5", "4y0w", "4ydu", "5br9", "6n9a", "6nak", "6s84", "6z81" ]

16

[ "PUB00063355", "PUB00063366" ]

[ "22378793", "23072323" ]

[ "Biosynthesis of threonylcarbamoyl adenosine (t6A), a universal tRNA nucleoside.", "Mechanism of N6-Threonylcarbamoyladenonsine (t(6)A) Biosynthesis: Isolation and Characterization of the Intermediate Threonylcarbamoyl-AMP." ]

[ 2012, 2012 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 24464, 33, 515 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

tRNA threonylcarbamoyl adenosine modification protein TsaB

T6A_TsaB

6

IPR022497

22,497

ABC transporter, urea permease, UrtC

ABC_trnspt_urea_permease_UrtC

Family

27

false

Members of this protein family are ABC transporter permease subunits restricted to the Archaea. Several lines of evidence suggest this protein is functionally analogous, as well as homologous, to the UrtC subunit of the Corynebacterium glutamicum urea transporter. All members of the operon show sequence similarity to u...

[]

0

[ "NCBIFAM" ]

[ "TIGR03727" ]

[ "urea_t_UrtC_arc" ]

[ 27 ]

1

[ "GP" ]

[ "GenProp0743" ]

[ "GP:GenProp0743" ]

1

[]

0

[]

0

[ "IPR001851" ]

[]

1

0

1

[ "Halobacteriales" ]

[ 27 ]

1

[]

0

true

Family

ABC transporter, urea permease, UrtC

ABC_trnspt_urea_permease_UrtC

1

IPR022498

22,498

Tungstate ABC transporter, substrate-binding protein WtpA

ABC_trnspt_W-bd_WtpA

Family

285

false

Members of this protein family are tungstate (and, more weakly, molybdate) binding proteins of tungstate(/molybdate) ABC transporters, as first characterised in Pyrococcus furiosus. Note that this family is homologous to molybdate transporters, and that at least one other family of tungstate transporter binding protein...

[ "GO:1901359" ]

[ "tungstate binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03730" ]

[ "tungstate_WtpA" ]

[ 285 ]

1

[]

0

[ "2onk", "2onr", "2ons", "3cfx", "3cfz", "3cg1", "3cg3", "3cij", "3k6u", "3k6v", "3k6w", "3k6x" ]

12

[ "PUB00071925", "PUB00071938" ]

[ "18310026", "8003968" ]

[ "Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acidic amino acid uptake: biochemical properties and regulation by the Aau two-component system.", "Sequence relationships between integral inner membrane proteins of binding protein-dependent transport systems: evolution by recurren...

[ 2008, 1994 ]

2

[ "IPR050682" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 184, 95, 6 ]

3

[]

0

true

Family

Tungstate ABC transporter, substrate-binding protein WtpA

ABC_trnspt_W-bd_WtpA

7

IPR022499

22,499

ParB-related, ThiF-related cassette, protein A

PRTRC_protein-A

Family

294

false

A novel genetic system characterised by six major proteins, included a ParB homologue and a ThiF homologue, is designated PRTRC, or ParB-Related,ThiF-Related Cassette. It is often found on plasmids. This protein family is designated protein A.

[]

0

[ "NCBIFAM" ]

[ "TIGR03735" ]

[ "PRTRC_A" ]

[ 294 ]

1

[ "GP" ]

[ "GenProp0854" ]

[ "GP:GenProp0854" ]

1

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "Ralstonia phage Dina", "ecological metagenomes" ]

[ 290, 1, 3 ]

3

[]

0

true

Family

ParB-related, ThiF-related cassette, protein A

PRTRC_protein-A

8

IPR022500

22,500

ParB-related, ThiF-related cassette, ThiF

PRTRC_ThiF

Family

1,230

false

A novel genetic system characterised by six major proteins, included a ParB homologue and a ThiF homologue, is designated PRTRC, or ParB-Related,ThiF-Related Cassette. This family is the PRTRC system ThiF family protein.

[]

0

[ "NCBIFAM" ]

[ "TIGR03736" ]

[ "PRTRC_ThiF" ]

[ 1230 ]

1

[ "GP" ]

[ "GenProp0854" ]

[ "GP:GenProp0854" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 1219, 2, 9 ]

3

[]

0

true

Family

ParB-related, ThiF-related cassette, ThiF

PRTRC_ThiF

1

IPR022501

22,501

Gallidermin ABC transporter, ATP-binding subunit

ABC_Gallidermin_ATP-bd

Family

986

false

Entry represents the family of all lantibiotics related to gallidermin, including epidermin, mutatin, and nisin. This protein family describes the ATP-binding subunit of a gallidermin/epidermin class lantibiotic protection transporter. It is largely restricted to gallidermin-family lantibiotic biosynthesis and export c...

[]

0

[ "NCBIFAM" ]

[ "TIGR03740" ]

[ "galliderm_ABC" ]

[ 986 ]

1

[ "GP" ]

[ "GenProp0853" ]

[ "GP:GenProp0853" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 986 ]

1

[]

0

true

Family

Gallidermin ABC transporter, ATP-binding subunit

ABC_Gallidermin_ATP-bd

8

IPR022502

22,502

Sulfopyruvate decarboxylase, alpha subunit

Sulfopyruvate_deCO2ase_alpha

Domain

357

false

This entry represents the alpha subunit, or the N-terminal region, of sulfopyruvate decarboxylase, an enzyme of coenzyme M biosynthesis. Coenzyme M is found almost exclusively in the methanogenic archaea. However, the enzyme also occurs in Roseovarius nubinhibens ISM in a degradative pathway, where the resulting sulfoa...

[ "GO:0030976", "GO:0050545" ]

[ "thiamine pyrophosphate binding", "sulfopyruvate decarboxylase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR03845" ]

[ "sulfopyru_alph" ]

[ 357 ]

1

[ "EC", "GP", "METACYC", "METACYC" ]

[ "4.1.1.79", "GenProp0891", "PWY-6637", "PWY-6643" ]

[ "EC:4.1.1.79", "GP:GenProp0891", "METACYC:PWY-6637", "METACYC:PWY-6643" ]

4

[]

0

[ "PUB00010733", "PUB00053709" ]

[ "10940029", "19581363" ]

[ "Identification of the gene encoding sulfopyruvate decarboxylase, an enzyme involved in biosynthesis of coenzyme M.", "Bifurcated degradative pathway of 3-sulfolactate in Roseovarius nubinhibens ISM via sulfoacetaldehyde acetyltransferase and (S)-cysteate sulfolyase." ]

[ 2000, 2009 ]

2

[ "IPR012001" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriati", "ecological metagenomes" ]

[ 118, 222, 17 ]

3

[]

0

true

Domain

Sulfopyruvate decarboxylase, alpha subunit

Sulfopyruvate_deCO2ase_alpha

1

IPR022503

22,503

Conjugative coupling factor TraG/TraD, PFGI-1

Conj_coupling_TraG/TraD_PFGI-1

Family

1,783

false

Members of this family are assigned by homology to the TraD family of conjugative coupling factor. This particular clade serves as a marker for an extended gene region that occurs occasionally on plasmids, including the toluene catabolism TOL plasmid. More commonly, the gene region is chromosomal, flanked by various ma...

[]

0

[ "NCBIFAM" ]

[ "TIGR03754" ]

[ "conj_TOL_TraD" ]

[ 1783 ]

1

[ "GP" ]

[ "GenProp0855" ]

[ "GP:GenProp0855" ]

1

[]

0

[]

0

[ "IPR022458" ]

[]

1

0

1

[ "Eukaryota", "Pseudomonadota", "metagenomes" ]

[ 2, 1763, 18 ]

3

[]

0

true

Family

Conjugative coupling factor TraG/TraD, PFGI-1

Conj_coupling_TraG/TraD_PFGI-1

4

IPR022504

22,504

Exosortase, archaea

Exosortase_arc

Family

39

false

Members of this family are archaeal homologues to bacterial PEP-CTERM-sorting protein exosortase ( ) [ ]. Members of this family are found in species with an archaeal variant sorting motif, PEF-CTE ( ). They are found in the thermoacidophilic Aciduliprofundum boonei, the mesophilic psychromethanogens Methanosarcina maz...

[]

0

[ "NCBIFAM" ]

[ "TIGR03762" ]

[ "archaeo_artC" ]

[ 39 ]

1

[ "GP" ]

[ "GenProp0979" ]

[ "GP:GenProp0979" ]

1

[]

0

[ "PUB00060405" ]

[ "22037399" ]

[ "Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification." ]

[ 2012 ]

1

[ "IPR019127" ]

[]

1

0

1

[ "Methanobacteriati" ]

[ 39 ]

1

[]

0

true

Family

Exosortase, archaea

Exosortase_arc

9

IPR022505

22,505

Exosortase, cyanobacteria

Exosortase_cyanobac

Family

163

false

The predicted protein-sorting transpeptidase that we call exosortase (see ) has distinct subclasses that associated with different types of exopolysaccharide production loci and/or different taxonomic lineages. We designate this relatively divergent cyanobacterial type to be type 3. We propose the gene symbol xrtC. Thi...

[]

0

[ "NCBIFAM" ]

[ "TIGR03763" ]

[ "cyanoexo_CrtA" ]

[ 163 ]

1

[ "GP" ]

[ "GenProp0987" ]

[ "GP:GenProp0987" ]

1

[]

0

[]

0

[ "IPR019127" ]

[]

1

0

1

[ "Cyanophyceae" ]

[ 163 ]

1

[]

0

true

Family

Exosortase, cyanobacteria

Exosortase_cyanobac

7

IPR022506

22,506

Metallophosphoesterase, PPA1498

Metallophosphoesterase_PPA1498

Family

1,148

false

This entry describes a small collection of probable metallophosphoresterases, related to but with long inserts separating some of the shared motifs such that the homology is apparent only through multiple sequence alignment. Members of this protein family, in general, have a Sec-independent TAT (twin-arginine transloca...

[]

0

[ "NCBIFAM" ]

[ "TIGR03767" ]

[ "P_acnes_RR" ]

[ 1148 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1124, 24 ]

2

[]

0

true

Family

Metallophosphoesterase, PPA1498

Metallophosphoesterase_PPA1498

1

IPR022508

22,508

ABC transporter, anchored repeat-type, ATP-binding subunit

ABC_trspt_anch-rpt_ATP-bd

Family

457

false

This protein family is the ATP-binding cassette subunit of binding protein-dependent ABC transporter complex that strictly co-occurs with . TIGRFAMs model describes a protein domain that occurs singly or as one of up to three repeats in proteins of a number of Actinobacteria, including Propionibacterium acnes KPA171202...

[]

0

[ "NCBIFAM" ]

[ "TIGR03771" ]

[ "anch_rpt_ABC" ]

[ 457 ]

1

[ "GP" ]

[ "GenProp0857" ]

[ "GP:GenProp0857" ]

1

[]

0

[]

0

[]

0

null

[ "Actinomycetota" ]

[ 457 ]

1

[]

0

true

Family

ABC transporter, anchored repeat-type, ATP-binding subunit

ABC_trspt_anch-rpt_ATP-bd

9

IPR022509

22,509

Conjugation system ATPase, TraG

Conjugation_ATPase_TraG

Family

3,535

false

Members of this family include the predicted ATPase, TraG, encoded by transfer region genes of conjugative transposons of Bacteroides, such as CTnDOT, found on the main chromosome. Members also include TraG homologues residing on plasmids in Bacteroides. The protein family is related to the conjugative transfer system ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03783" ]

[ "Bac_Flav_CT_G" ]

[ 3535 ]

1

[ "GP" ]

[ "GenProp0858" ]

[ "GP:GenProp0858" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3474, 3, 58 ]

3

[]

0

true

Family

Conjugation system ATPase, TraG

Conjugation_ATPase_TraG

3

IPR022510

22,510

Sortase system, histidine kinase

Sortase_His-kinase

Family

345

false

This histidine kinase protein is paired with an adjacent response regulator ( ) gene. It co-occurs with a variant sortase enzyme ( ), usually in the same gene neighbourhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein ( ). Sortases and LPXTG p...

[]

0

[ "NCBIFAM" ]

[ "TIGR03785" ]

[ "marine_sort_HK" ]

[ 345 ]

1

[ "GP" ]

[ "GenProp0859" ]

[ "GP:GenProp0859" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 333, 12 ]

2

[]

0

true

Family

Sortase system, histidine kinase

Sortase_His-kinase

9

IPR022511

22,511

Proteobacterial sortase system peptidoglycan-associated protein

PdsO

Family

287

false

A newly defined histidine kinase ( ) and response regulator ( ) gene pair occurs exclusively in Proteobacteria, mostly of marine origin, nearly all of which contain a subfamily 6 sortase ( ) and its single dedicated target protein ( ) adjacent to to the sortase. This protein family shows up in only in those species wit...

[]

0

[ "NCBIFAM" ]

[ "TIGR03789" ]

[ "pdsO" ]

[ 287 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 285, 2 ]

2

[]

0

true

Family

Proteobacterial sortase system peptidoglycan-associated protein

PdsO

1

IPR022512

22,512

Conserved hypothetical protein CHP03792

CHP03792

Family

288

false

Members of this family are found predominantly in Cyanobacteria. These proteins are small, with around 100-150 amino acids. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "TIGR03792" ]

[ "" ]

[ 288 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 269, 5, 14 ]

3

[]

0

true

Family

Conserved hypothetical protein CHP03792

CHP03792

1

IPR022513

22,513

NHLP leader peptide domain

TOMM_pelo

Domain

872

false

This entry represents a domain that is conserved among a large number of putative thiazole/oxazole-modified microcins (TOMM), including PoyA from Bacterium symbiont subsp. Theonella swinhoei. As a leader peptide domain, it is likely to be removed from the mature product. This domain is unusual in several ways. First, i...

[]

0

[ "NCBIFAM" ]

[ "TIGR03793" ]

[ "leader_NHLP" ]

[ 872 ]

1

[ "GP" ]

[ "GenProp0861" ]

[ "GP:GenProp0861" ]

1

[ "8tb1", "9cjx" ]

2

[ "PUB00055015", "PUB00074064" ]

[ "20500830", "22983711" ]

[ "Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family.", "Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides." ]

[ 2010, 2012 ]

2

[ "IPR004232" ]

[]

1

0

1

[ "Bacteria", "Methanosarcina", "marine sediment metagenome" ]

[ 869, 2, 1 ]

3

[]

0

true

Domain

NHLP leader peptide domain

TOMM_pelo

7

IPR022514

22,514

NHPM bacteriocin system ABC transporter, peptidase/ATP-binding protein

NHPM_micro_ABC1

Family

1,310

false

This protein describes an multidomain ABC transporter subunit that is one of three protein families associated with some regularity with a distinctive family of putative bacteriocins. It includes a bacteriocin-processing peptidase domain at the N terminus. describes a conserved propeptide region for this bacteriocin fa...

[]

0

[ "NCBIFAM" ]

[ "TIGR03796" ]

[ "NHLM_micro_ABC1" ]

[ 1310 ]

1

[ "GP" ]

[ "GenProp0861" ]

[ "GP:GenProp0861" ]

1

[]

0

[]

0

[ "IPR039421" ]

[]

1

0

1

[ "Bacteria", "Methanoplanus endosymbiosus", "ecological metagenomes" ]

[ 1304, 1, 5 ]

3

[]

0

true

Family

NHPM bacteriocin system ABC transporter, peptidase/ATP-binding protein

NHPM_micro_ABC1

3

IPR022515

22,515

NHPM bacteriocin system ABC transporter, ATP-binding protein

NHPM_micro_ABC2

Family

1,232

false

Members of this protein family are ABC transporter ATP-binding subunits, part of a three-gene putative bacteriocin transport operon. The other subunits include another ATP-binding subunit ( ), which has an N-terminal propeptide cleavage domain, and an HlyD homologue ( ). In a number of genomes, a conserved propeptide s...

[]

0

[ "NCBIFAM" ]

[ "TIGR03797" ]

[ "NHLM_micro_ABC2" ]

[ 1232 ]

1

[ "GP" ]

[ "GenProp0861" ]

[ "GP:GenProp0861" ]

1

[]

0

[]

0

[ "IPR039421" ]

[]

1

0

1

[ "Bacteria", "Darwinula stevensoni", "Methanoplanus endosymbiosus", "ecological metagenomes" ]

[ 1227, 1, 1, 3 ]

4

[]

0

true

Family

NHPM bacteriocin system ABC transporter, ATP-binding protein

NHPM_micro_ABC2

6

IPR022516

22,516

Nif11-like leader peptide

CHP03798_Ocin

Domain

1,073

false

This entry describes a conserved, fairly long (about 65 residue) leader peptide region for a family of putative ribosomal natural products (RNP) of small size. Members of the seed alignment (most sequences scoring better than 54 bits to the HMMER 2 model) tend to have the Gly-Gly motif as the last two residues of the m...

[]

0

[ "NCBIFAM" ]

[ "TIGR03798" ]

[ "leader_Nif11" ]

[ 1073 ]

1

[ "GP" ]

[ "GenProp0861" ]

[ "GP:GenProp0861" ]

1

[]

0

[ "PUB00055015", "PUB00074065" ]

[ "20500830", "22574919" ]

[ "Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family.", "Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria." ]

[ 2010, 2012 ]

2

[ "IPR012903" ]

[]

1

0

1

[ "Bacteria", "Methanoplanus endosymbiosus", "ecological metagenomes" ]

[ 1044, 5, 24 ]

3

[]

0

true

Domain

Nif11-like leader peptide

CHP03798_Ocin

3

IPR022517

22,517

Aspartate 1-decarboxylase, pyridoxal-dependent

Asp_decarboxylase_pyridox

Family

995

false

This enzyme is proposed here to be a form of aspartate 1-decarboxylase, pyridoxal-dependent, that represents a non-orthologous displacement to the more widely distributed pyruvoyl-dependent form ( ). Aspartate 1-decarboxylase makes beta-alanine, used usually in pathothenate biosynthesis, by decarboxylation from asparat...

[]

0

[ "NCBIFAM" ]

[ "TIGR03799" ]

[ "NOD_PanD_pyr" ]

[ 995 ]

1

[ "GP" ]

[ "GenProp0124" ]

[ "GP:GenProp0124" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 993, 2 ]

2

[]

0

true

Family

Aspartate 1-decarboxylase, pyridoxal-dependent

Asp_decarboxylase_pyridox

2

IPR022518

22,518

Aspartate 4-decarboxylase

Aspartate_4-decarboxylase

Family

1,855

false

This enzyme, aspartate 4-decarboxylase ( ), removes the side-chain carboxylate from L-aspartate, converting it to L-alanine plus carbon dioxide. It is a PLP-dependent enzyme, homologous to aspartate aminotransferase ( ).

[]

0

[ "NCBIFAM" ]

[ "TIGR03801" ]

[ "asp_4_decarbox" ]

[ 1855 ]

1

[ "GP" ]

[ "GenProp0867" ]

[ "GP:GenProp0867" ]

1

[ "2zy2", "2zy3", "2zy4", "2zy5", "3f6t", "3fdd" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 1817, 24, 4, 10 ]

4

[]

0

true

Family

Aspartate 4-decarboxylase

Aspartate_4-decarboxylase

7

IPR022519

22,519

Gloeobacter/Verrucomicrobia repeat

Gloeo/Verruco_rpt

Repeat

444

false

This entry describes a repeat originally found in proteins from some species of Verrucomicrobia (such as Chthoniobacter flavus) and in four different proteins of Gloeobacter violaceus PCC7421. In the Verrucomicrobial species, the repeat region is followed by a PEP-CTE protein-sorting signal, suggesting an extracellular...

[]

0

[ "NCBIFAM" ]

[ "TIGR03803" ]

[ "Gloeo_Verruco" ]

[ 444 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "Pithovirus LCPAC304", "metagenomes" ]

[ 402, 30, 1, 11 ]

4

[]

0

true

Repeat

Gloeobacter/Verrucomicrobia repeat

Gloeo/Verruco_rpt

1

IPR022520

22,520

Putative glutamate/gamma-aminobutyrate antiporter

Glu/GABA_antiporter_put

Family

491

false

Members of this protein family (GadC) are antiporters thought to import glutamine and export gamma-aminobutyrate as part of an acid resistance system, although glutamate might also be transported. Some members are found adjacent to a glutamate decarboxylase (GadB), which converts glutamate (Glu) to gamma-aminobutyrate ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03813" ]

[ "put_Glu_GABA_T" ]

[ 491 ]

1

[]

0

[]

0

[]

0

[ "IPR002293" ]

[]

1

0

1

[ "Bacteria", "gut metagenome" ]

[ 490, 1 ]

2

[]

0

true

Family

Putative glutamate/gamma-aminobutyrate antiporter

Glu/GABA_antiporter_put

3

IPR022521

22,521

Rv3660c

Family

3,211

false

Rv3660c from Mycobacterium tuberculosis (Septum site determining protein, Ssd) plays a role in septum formation [ , ]. Members of this protein family belong to the MinD/ParA family of P-loop NTPases, and in particular show homology to the CpaE family of pilus assembly proteins [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR03815" ]

[ "CpaE_hom_Actino" ]

[ 3211 ]

1

[]

0

[]

0

[ "PUB00053710", "PUB00059195", "PUB00135927" ]

[ "12370432", "16735741", "21504606" ]

[ "Identification of a localization factor for the polar positioning of bacterial structural and regulatory proteins.", "Identification of cell cycle regulators in Mycobacterium tuberculosis by inhibition of septum formation and global transcriptional analysis.", "Mycobacterium tuberculosis septum site determinin...

[ 2002, 2006, 2011 ]

3

[]

0

null

[ "Bacteria", "Pleodorina starrii", "metagenomes" ]

[ 3183, 1, 27 ]

3

[]

0

true

Family

Rv3660c

6

IPR022522

22,522

Flagellar motor stator, MotA

Flagellar_motor_stator_MotA

Family

7,131

false

The MotA protein, along with its partner MotB, comprises the stator complex of the bacterial flagellar motor. MotAB span the cytoplasmic membrane and undergo conformational changes powered by the translocation of protons. These conformational changes in turn are communicated to the rotor assembly, producing torque [ , ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03818" ]

[ "MotA1" ]

[ 7131 ]

1

[ "GP" ]

[ "GenProp0877" ]

[ "GP:GenProp0877" ]

1

[]

0

[ "PUB00053711", "PUB00099519" ]

[ "19683537", "32929189" ]

[ "Role of a conserved prolyl residue (Pro173) of MotA in the mechanochemical reaction cycle of the proton-driven flagellar motor of Salmonella.", "Structures of the stator complex that drives rotation of the bacterial flagellum." ]

[ 2009, 2020 ]

2

[ "IPR047055" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7070, 6, 55 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar motor stator, MotA

Flagellar_motor_stator_MotA

5

IPR022523

22,523

Flagellar regulator, FliZ

Flagellar_regulator_FliZ

Family

1,125

false

FliZ is involved in the regulation of flagellar assembly [ ] and possibly also the down-regulation of the motile phenotype [ ]. FliZ interacts with the flagellar translational activator FlhCD complex.

[]

0

[ "NCBIFAM" ]

[ "TIGR03823" ]

[ "FliZ" ]

[ 1125 ]

1

[]

0

[]

0

[ "PUB00053712", "PUB00053713" ]

[ "18469103", "18765794" ]

[ "FliZ Is a posttranslational activator of FlhD4C2-dependent flagellar gene expression.", "Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli." ]

[ 2008, 2008 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 1123, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar regulator, FliZ

Flagellar_regulator_FliZ

9

IPR022524

22,524

Flagellar assembly FliH, Bacilli

FliH_Bacilli

Family

824

false

This entry represents a bacillus clade of FliH proteins. Sequences in this entry are observed in flagellar operons in an analogous position relative to other flagellar operon genes.

[]

0

[ "NCBIFAM" ]

[ "TIGR03825" ]

[ "FliH_bacil" ]

[ 824 ]

1

[ "GP" ]

[ "GenProp0879" ]

[ "GP:GenProp0879" ]

1

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 824 ]

1

[]

0

true

Family

Flagellar assembly FliH, Bacilli

FliH_Bacilli

8

IPR022525

22,525

Beta-lysine N-acetyltransferase

GNAT_AblB

Family

1,094

false

Members of this protein family are GNAT family acetyltransferases, based on a seed alignment in which every member is associated with a lysine 2,3-aminomutase family protein, usually as the adjacent gene. This family includes AblB, the enzyme beta-lysine acetyltransferase that completes the two-step synthesis of the os...

[ "GO:0008080" ]

[ "N-acetyltransferase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03827" ]

[ "GNAT_ablB" ]

[ 1094 ]

1

[ "EC", "GP" ]

[ "2.3.1.264", "GenProp0878" ]

[ "EC:2.3.1.264", "GP:GenProp0878" ]

2

[]

0

[ "PUB00094540" ]

[ "14532061" ]

[ "Lysine-2,3-aminomutase and beta-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of Nepsilon-acetyl-beta-lysine and growth at high salinity." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Carpediemonas membranifera", "Methanobacteriota", "ecological metagenomes" ]

[ 975, 2, 108, 9 ]

4

[]

0

true

Family

Beta-lysine N-acetyltransferase

GNAT_AblB

2

IPR022527

22,527

Sucrose phosphorylase

Sucrose_phospho

Family

1,737

false

This family includes glycoside phosphorylases that act on alpha-glucosides. Characterised representatives from Streptococcus mutans and Bifidobacterium adolescentis are sucrose phosphorylases. In the forward direction, sucrose phosphorylase uses phosphate to cleave sucrose into D-fructose + alpha-D-glucose 1-phosphate ...

[ "GO:0004645", "GO:0005975" ]

[ "1,4-alpha-oligoglucan phosphorylase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR03852", "cd11355" ]

[ "sucrose_gtfA", "AmyAc_Sucrose_phosphorylase" ]

[ 1737, 1269 ]

2

[ "EC", "METACYC" ]

[ "2.4.1.7", "PWY-5384" ]

[ "EC:2.4.1.7", "METACYC:PWY-5384" ]

2

[ "1r7a", "2gdu", "2gdv", "5c8b", "5m9x", "5man", "5mb2", "6fme", "6s9v", "7qqi", "7qqj", "7xdq", "7xdr", "7znp", "9j1u", "9j24", "9j25" ]

17

[ "PUB00080588", "PUB00089256" ]

[ "1537846", "29470619" ]

[ "A binding protein-dependent transport system in Streptococcus mutans responsible for multiple sugar metabolism.", "Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase." ]

[ 1992, 2018 ]

2

[ "IPR016377" ]

[]

1

0

1

[ "Bacteria", "Viridiplantae", "ecological metagenomes" ]

[ 1710, 19, 8 ]

3

[]

0

true

Family

Sucrose phosphorylase

Sucrose_phospho

9

IPR022528

22,528

6-phosphogluconolactonase, YbhE-like

6PGL_YbhE-like

Family

1,479

false

This entry refers to the 6-phosphogluconolactonase YbhE type proteins found mainly in enterobacteriaceae organisms. 6-phosphogluconolactonases (6PGL) are cytosolic enzymes found in all organisms that catalyse the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose phosp...

[ "GO:0017057", "GO:0005975", "GO:0006098" ]

[ "6-phosphogluconolactonase activity", "carbohydrate metabolic process", "pentose-phosphate shunt" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01605", "NF008258" ]

[ "6P_gluconolactonase", "PRK11028.1" ]

[ 1314, 1478 ]

2

[ "EC", "METACYC" ]

[ "3.1.1.31", "PWY-8004" ]

[ "EC:3.1.1.31", "METACYC:PWY-8004" ]

2

[ "1ri6", "6nau" ]

2

[ "PUB00017646", "PUB00051612", "PUB00053730", "PUB00158686", "PUB00160401", "PUB00160402" ]

[ "10869070", "19345229", "15576773", "25613812", "1719698", "35858355" ]

[ "The Pseudomonas aeruginosa devB/SOL homolog, pgl, is a member of the hex regulon and encodes 6-phosphogluconolactonase.", "Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation.", "Identification of the Escherichia col...

[ 2000, 2009, 2004, 2015, 1991, 2022 ]

6

[ "IPR019405" ]

[]

1

0

1

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 1478, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

6-phosphogluconolactonase, YbhE-like

6PGL_YbhE-like

4

IPR022529

22,529

Protein of unknown function DUF3530

DUF3530

Family

1,743

false

This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 272 to 336 amino acids in length. These proteins are distantly related to alpa/beta hydrolases so they may act as enzymes.

[]

0

[ "PFAM" ]

[ "PF12048" ]

[ "DUF3530" ]

[ 1743 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Mesangiospermae", "ecological metagenomes" ]

[ 1694, 2, 47 ]

3

[]

0

true

Family

Protein of unknown function DUF3530

DUF3530

5

IPR022531

22,531

RNA-directed RNA polymerase L, PA-C-like domain

L_PA-C-like

Domain

1,016

false

This domain is found in RNA-directed RNA polymerase L from Bunyavirales. This has been described as the PA-C like domain, which forms a narrow and positively charged cleft with the thumb domain, where the 3' RNA is likely bound [ ].

[]

0

[ "PFAM" ]

[ "PF12603" ]

[ "L_PA-C-like" ]

[ 1016 ]

1

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[ "6l42", "6y6k", "7alp", "7eei", "8as6", "8as7", "8asb", "8asd", "8asg", "8r6u", "8r6w", "8r6y", "9qtb" ]

13

[ "PUB00101134" ]

[ "32313945" ]

[ "Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein." ]

[ 2020 ]

1

[]

0

null

[ "Eumetazoa", "Viruses" ]

[ 7, 1009 ]

2

[]

0

true

Domain

RNA-directed RNA polymerase L, PA-C-like domain

L_PA-C-like

1

IPR022532

22,532

Domain of unknown function DUF3696, C-terminal

DUF3696

Domain

1,438

false

This domain is found in bacteria and archaea, and is approximately 50 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF12476" ]

[ "DUF3696" ]

[ 1438 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Metazoa", "metagenomes" ]

[ 13, 1391, 3, 31 ]

4

[]

0

true

Domain

Domain of unknown function DUF3696, C-terminal

DUF3696

6