interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR022305 | 22,305 | Sortase system response regulator | Response_regulator | Family | 646 | false | false | This entry describes a group of DNA-binding response regulator proteins that associate with histidine kinase ( ) to form a two-component system. This system co-occurs with a proteobacterial variant form of the protein sorting transpeptidase called sortase ( ), and a single target protein for the sortase. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03787"
] | [
"marine_sort_RR"
] | [
646
] | 1 | [
"GP"
] | [
"GenProp0859"
] | [
"GP:GenProp0859"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR039420"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"ecological metagenomes"
] | [
631,
15
] | 2 | [] | [] | 0 | true | Family | Sortase system response regulator | Sortase system response regulator | Response_regulator | 1 |
IPR022307 | 22,307 | DEAD/DEAH-box helicase, putative, actinobacteria | Helicase_put_actinobac | Family | 3,485 | false | false | A conserved gene neighbourhood widely spread in the Actinobacteria contains this uncharacterised DEAH-box family helicase. The operons are similar to operons encoding type II secretion and pilus formation proteins. The context suggests that this helicase may play a role in conjugal transfer of DNA. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03817"
] | [
"DECH_helic"
] | [
3485
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Pleodorina starrii",
"metagenomes"
] | [
3459,
1,
25
] | 3 | [] | [] | 0 | true | Family | DEAD/DEAH-box helicase, putative, actinobacteria | DEAD/DEAH-box helicase, putative, actinobacteria | Helicase_put_actinobac | 7 |
IPR022308 | 22,308 | Synaptic vesicle protein SV2 | SV2 | Family | 3,348 | false | false | SV2 proteins are abundant synaptic vesicle proteins expressed in two major (SV2A and SV2B) and one minor isoform (SV2C) that resemble transporter proteins. SV2B knockout mice are phenotypically normal while SV2A-and SV2A/SV2B double knockout mice exhibit severe seizures and die postnatally. Without SV2 proteins, presyn... | [
"GO:0007268",
"GO:0016020"
] | [
"chemical synaptic transmission",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01299"
] | [
"synapt_SV2"
] | [
3348
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5250955",
"R-HSA-5250968",
"R-HSA-5250981",
"R-HSA-5250992"
] | [
"REACTOME:R-HSA-5250955",
"REACTOME:R-HSA-5250968",
"REACTOME:R-HSA-5250981",
"REACTOME:R-HSA-5250992"
] | 4 | [
"8jlc",
"8jlf",
"8jlh",
"8jli",
"8js8",
"8js9",
"8k77",
"8uo8",
"8uo9",
"8uoa",
"8yf0",
"8yf1",
"9f1r",
"9f2b",
"9f2j",
"9f2y",
"9f3c",
"9fyq",
"9fyr",
"9ntc",
"9pc9",
"9pcb"
] | 22 | [
"PUB00007920"
] | [
"10624962"
] | [
"SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release."
] | [
1999
] | 1 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Chordata"
] | [
3348
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
5,
5,
11
] | 4 | true | Family | Synaptic vesicle protein SV2 | Synaptic vesicle protein SV2 | SV2 | 6 |
IPR022309 | 22,309 | Ribosomal protein eS8/ribosomal biogenesis NSA2 | Ribosomal_Se8/biogenesis_NSA2 | Family | 13,423 | false | false | This entry represents the small ribosomal subunit protein eS8 from archaea and eukaryotes [ , ], which consists of a number of proteins with either about 220 amino acids (in eukaryotes) or about 125 amino acids (in archaea). This entry also contains proteins annotated as NSA2, which are though to be involved in ribosom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01201"
] | [
"Ribosomal_S8e"
] | [
13423
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72649",
"R-CEL-72689",
"R-CEL-72695",
"R-CEL-72702",
"R-CEL-72706",
"R-CEL-975956",
... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72695",
"REACTOME:R-BTA-72702",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-179933... | 92 | [
"2kco",
"2kcp",
"2kcy",
"2mvf",
"3j6x",
"3j6y",
"3j77",
"3j78",
"3j7a",
"3j7p",
"3j7r",
"3j80",
"3j81",
"3jag",
"3jah",
"3jai",
"3jaj",
"3jam",
"3jan",
"3jap",
"3jbn",
"3jbo",
"3jbp",
"3jct",
"4bts",
"4d5l",
"4d61",
"4kzx",
"4kzy",
"4kzz",
"4u3m",
"4u3n"... | 724 | [
"PUB00003471",
"PUB00110894"
] | [
"7662106",
"23636399"
] | [
"Amino acid sequence of the ribosomal protein HS23 from the halophilic Haloarcula marismortui and homology studies to other ribosomal proteins.",
"Structures of the human and Drosophila 80S ribosome."
] | [
1995,
2013
] | 2 | [] | [
"IPR001047",
"IPR039411"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
895,
8,
12483,
37
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
3,
4,
3,
7,
10,
2,
6,
11,
3,
3,
39
] | 12 | true | Family | Ribosomal protein eS8/ribosomal biogenesis NSA2 | Ribosomal protein eS8/ribosomal biogenesis NSA2 | Ribosomal_Se8/biogenesis_NSA2 | 1 |
IPR022310 | 22,310 | NAD/GMP synthase | NAD/GMP_synthase | Domain | 65,161 | false | false | NAD+ synthase ( ) catalyzes the last step in the biosynthesis of nicotinamide adenine dinucleotide and is induced by stress factors such as heat shock and glucose limitation. The three-dimensional structure of NH3-dependent NAD+ synthetase from Bacillus subtilis, in its free form and in complex with ATP shows that the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02540"
] | [
"NAD_synthase"
] | [
65161
] | 1 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"6.3.5.2",
"GenProp1650",
"PWY-7221",
"R-BTA-196807",
"R-CEL-73817",
"R-CEL-9748787",
"R-DDI-196807",
"R-DDI-73817",
"R-DDI-9748787",
"R-DME-196807",
"R-HSA-196807",
"R-HSA-73817",
"R-HSA-9748787",
"R-MMU-196807",
"R-MMU-73817",
"R-MMU-9748787",
"R-PFA-73817",
"R-PFA-9748787",
"R... | [
"EC:6.3.5.2",
"GP:GenProp1650",
"METACYC:PWY-7221",
"REACTOME:R-BTA-196807",
"REACTOME:R-CEL-73817",
"REACTOME:R-CEL-9748787",
"REACTOME:R-DDI-196807",
"REACTOME:R-DDI-73817",
"REACTOME:R-DDI-9748787",
"REACTOME:R-DME-196807",
"REACTOME:R-HSA-196807",
"REACTOME:R-HSA-73817",
"REACTOME:R-HSA-... | 25 | [
"1ee1",
"1fyd",
"1gpm",
"1ifx",
"1ih8",
"1kqp",
"1nsy",
"1wxe",
"1wxf",
"1wxg",
"1wxh",
"1wxi",
"1xng",
"1xnh",
"2dpl",
"2e18",
"2nsy",
"2pz8",
"2pza",
"2pzb",
"2vxo",
"3a4i",
"3dla",
"3dpi",
"3fiu",
"3hmq",
"3ilv",
"3n05",
"3p52",
"3q4g",
"3sdb",
"3seq"... | 75 | [
"PUB00008175"
] | [
"8895556"
] | [
"Crystal structure of NH3-dependent NAD+ synthetase from Bacillus subtilis."
] | [
1996
] | 1 | [] | [
"IPR025777"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2290,
52133,
9362,
24,
1352
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
3,
4,
2,
5,
2,
7,
4,
2,
3,
13,
2,
1,
19
] | 13 | true | Domain | NAD/GMP synthase | NAD/GMP synthase | NAD/GMP_synthase | 3 |
IPR022312 | 22,312 | DNA polymerase family X | DNA_pol_X | Family | 11,292 | false | false | Family X DNA polymerases (PolX) are involved in DNA repair, being evolutionarily conserved in prokaryotes, eukaryotes and archaea. All DNA polymerases from this family are single-subunit enzymes, lacking the 3'-5' exonuclease activity and displaying very low processivity during primer extension reactions [ ]. Proteins ... | [
"GO:0003677",
"GO:0003887",
"GO:0006281"
] | [
"DNA binding",
"DNA-directed DNA polymerase activity",
"DNA repair"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS",
"PANTHER"
] | [
"PR00869",
"PTHR11276"
] | [
"DNAPOLX",
""
] | [
9306,
10817
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.7",
"R-BTA-110362",
"R-BTA-110373",
"R-BTA-110381",
"R-BTA-5649702",
"R-BTA-5651801",
"R-BTA-5689880",
"R-BTA-73930",
"R-DRE-110362",
"R-DRE-110373",
"R-DRE-5649702",
"R-DRE-73930",
"R-HSA-110362",
"R-HSA-110373",
"R-HSA-110381",
"R-HSA-5649702",
"R-HSA-5651801",
"R-HSA-5689... | [
"EC:2.7.7.7",
"REACTOME:R-BTA-110362",
"REACTOME:R-BTA-110373",
"REACTOME:R-BTA-110381",
"REACTOME:R-BTA-5649702",
"REACTOME:R-BTA-5651801",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-73930",
"REACTOME:R-DRE-110362",
"REACTOME:R-DRE-110373",
"REACTOME:R-DRE-5649702",
"REACTOME:R-DRE-73930",
"... | 36 | [
"1bno",
"1bnp",
"1bpb",
"1bpd",
"1bpe",
"1bpx",
"1bpy",
"1bpz",
"1dk2",
"1dk3",
"1huo",
"1huz",
"1jaj",
"1jms",
"1jn3",
"1jqr",
"1kdh",
"1kej",
"1mq2",
"1mq3",
"1nom",
"1nzp",
"1rpl",
"1rzt",
"1tv9",
"1tva",
"1xsl",
"1xsn",
"1xsp",
"1zjm",
"1zjn",
"1zqa"... | 743 | [
"PUB00004647",
"PUB00004955",
"PUB00039714",
"PUB00097985",
"PUB00097986",
"PUB00097987",
"PUB00097988",
"PUB00097989"
] | [
"3479792",
"2196557",
"7516580",
"16120966",
"15588842",
"30005324",
"28811466",
"27481934"
] | [
"Bacteriophage PRD1 DNA polymerase: evolution of DNA polymerases.",
"An attempt to unify the structure of polymerases.",
"Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP.",
"Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe."... | [
1987,
1990,
1994,
2005,
2004,
2018,
2017,
2016
] | 8 | [] | [
"IPR001726",
"IPR002008"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
25,
840,
10020,
97,
310
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
5,
12,
38,
9,
2,
2,
15,
1,
1,
9
] | 10 | true | Family | DNA polymerase family X | DNA polymerase family X | DNA_pol_X | 1 |
IPR022313 | 22,313 | Phenylalanine/histidine ammonia-lyases, active site | Phe/His_NH3-lyase_AS | Active_site | 23,774 | false | false | This entry represents the active site of phenylalanine ammonia-lyase (PAL; ) and the mechanistically related protein histidine ammonia lyase (HAL; ). Both contain a catalytic Ala-Ser-Gly triad that is post-translationally cyclised [ ]. PAL is a key biosynthetic catalyst in phenylpropanoid assembly in plants and fungi, ... | [
"GO:0016841"
] | [
"ammonia-lyase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00488"
] | [
"PAL_HISTIDASE"
] | [
23774
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.3.1",
"4.3.1.3",
"PWY-5028",
"PWY-5030",
"R-BTA-70921",
"R-CEL-70921",
"R-DDI-70921",
"R-HSA-70921",
"R-MMU-70921",
"R-RNO-70921"
] | [
"EC:4.3.1",
"EC:4.3.1.3",
"METACYC:PWY-5028",
"METACYC:PWY-5030",
"REACTOME:R-BTA-70921",
"REACTOME:R-CEL-70921",
"REACTOME:R-DDI-70921",
"REACTOME:R-HSA-70921",
"REACTOME:R-MMU-70921",
"REACTOME:R-RNO-70921"
] | 10 | [
"1b8f",
"1eb4",
"1gk2",
"1gkj",
"1gkm",
"1t6j",
"1t6p",
"1w27",
"1y2m",
"2nyf",
"2nyn",
"2o6y",
"2o78",
"2o7b",
"2o7d",
"2o7e",
"2o7f",
"2ohy",
"2qve",
"2rjr",
"2rjs",
"2yii",
"3czo",
"3kdy",
"3kdz",
"3nz4",
"4baa",
"4bab",
"4c5r",
"4c5s",
"4c5u",
"4c6g"... | 43 | [
"PUB00000402",
"PUB00001676",
"PUB00002585",
"PUB00002875",
"PUB00031359",
"PUB00035855"
] | [
"8204579",
"8050576",
"2120224",
"7961661",
"15350127",
"16478474"
] | [
"Identification of serine-143 as the most likely precursor of dehydroalanine in the active site of histidine ammonia-lyase. A study of the overexpressed enzyme by site-directed mutagenesis.",
"Serine-202 is the putative precursor of the active site dehydroalanine of phenylalanine ammonia lyase. Site-directed muta... | [
1994,
1994,
1990,
1994,
2004,
2006
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae",
"unclassified sequences"
] | [
212,
16544,
6820,
2,
196
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
13,
1,
7,
3,
3,
21,
2,
40
] | 8 | true | Active_site | Phenylalanine/histidine ammonia-lyases, active site | Phenylalanine/histidine ammonia-lyases, active site | Phe/His_NH3-lyase_AS | 5 |
IPR022314 | 22,314 | Tyrosine 2,3-aminomutase, putative | Tyr_aminomutase | Family | 135 | false | false | This entry includes tyrosine 2,3-aminomutase and histidine ammonia-lyase. It is variable from member to member as to whether the (R)-beta-Tyr or (S)-beta-Tyr is the preferred product from L-Tyr. This enzyme tends to occur in secondary metabolite biosynthesis systems, as in the production of chondramides in Chondromyces... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03832"
] | [
"Tyr_2_3_mutase"
] | [
135
] | 1 | [
"EC",
"EC"
] | [
"4.3.1.23",
"5.4.3.6"
] | [
"EC:4.3.1.23",
"EC:5.4.3.6"
] | 2 | [
"2ohy",
"2qve",
"2rjr",
"2rjs",
"3kdy",
"3kdz"
] | 6 | [] | [] | [] | [] | 0 | [
"IPR001106"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
135
] | 1 | [] | [] | 0 | true | Family | Tyrosine 2,3-aminomutase, putative | Tyrosine 2,3-aminomutase, putative | Tyr_aminomutase | 3 |
IPR022315 | 22,315 | F420-dependent oxidoreductase-predicted, CPS4043 | F420_OxRdatse_CPS4043_pred | Family | 2,071 | false | false | This entry represents a group of putative F420-dependent oxidoreductases, fairly closely related to 5,10-methylenetetrahydromethanopterin reductase (mer, ). A fairly deep split (to about 40 % sequence identity) in the present family separates a strictly Actinobacterial clade from an alpha/beta/gamma-proteobacterial cla... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03842"
] | [
"F420_CPS_4043"
] | [
2071
] | 1 | [
"GP"
] | [
"GenProp0002"
] | [
"GP:GenProp0002"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"ecological metagenomes"
] | [
2039,
2,
30
] | 3 | [] | [] | 0 | true | Family | F420-dependent oxidoreductase-predicted, CPS4043 | F420-dependent oxidoreductase-predicted, CPS4043 | F420_OxRdatse_CPS4043_pred | 1 |
IPR022316 | 22,316 | Tumour necrosis factor receptor 12 | TNFR_12 | Family | 415 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of ... | [
"GO:0005515",
"GO:0043065",
"GO:0005886"
] | [
"protein binding",
"positive regulation of apoptotic process",
"plasma membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS",
"PANTHER",
"CDD"
] | [
"PF12191",
"PR01962",
"PTHR32037",
"cd13413"
] | [
"stn_TNFRSF12A",
"TNFACTORR12",
"",
"TNFRSF12A"
] | [
409,
242,
348,
149
] | 4 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5668541",
"R-HSA-5676594",
"R-MMU-5668541",
"R-MMU-5676594"
] | [
"REACTOME:R-HSA-5668541",
"REACTOME:R-HSA-5676594",
"REACTOME:R-MMU-5668541",
"REACTOME:R-MMU-5676594"
] | 4 | [
"2eqp",
"2kmz",
"2kn0",
"2rpj"
] | 4 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046034",
"PUB00053596",
"PUB00082433",
"PUB00082434"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826574",
"11728344",
"24478772",
"18404150"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
2001,
2014,
2008
] | 8 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
415
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
3,
5
] | 4 | true | Family | Tumour necrosis factor receptor 12 | Tumour necrosis factor receptor 12 | TNFR_12 | 7 |
IPR022317 | 22,317 | Tumour necrosis factor receptor 13B | TNFR_13B | Family | 828 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a... | [
"GO:0005886"
] | [
"plasma membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS",
"PANTHER",
"CDD"
] | [
"PR01963",
"PTHR15511",
"cd13415"
] | [
"TNFACTORR13B",
"",
"TNFRSF13B"
] | [
621,
828,
210
] | 3 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5669034",
"R-MMU-5669034"
] | [
"REACTOME:R-HSA-5669034",
"REACTOME:R-MMU-5669034"
] | 2 | [
"1xu1",
"1xut"
] | 2 | [
"PUB00000892",
"PUB00033576",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053598"
] | [
"8387891",
"10801128",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"16007086"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-... | [
1993,
2000,
1994,
2004,
2001,
1998,
1998,
2005
] | 8 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
828
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
6,
2
] | 4 | true | Family | Tumour necrosis factor receptor 13B | Tumour necrosis factor receptor 13B | TNFR_13B | 2 |
IPR022319 | 22,319 | Tumour necrosis factor receptor 27 | TNFR_27 | Family | 571 | false | false | TNF receptor 27 (also known as ectodysplasin A2 receptor (EDA2R) and ectodysplasin receptor, x-linked (XEDAR)) is highly expressed during embryogenesis [ ], and has been implicated in the development of ectodermal appendages, such as hair follicles, teeth and sweat glands [ ]. Although it lacks a death domain, the rece... | [
"GO:0005031",
"GO:0033209",
"GO:0005886"
] | [
"tumor necrosis factor receptor activity",
"tumor necrosis factor-mediated signaling pathway",
"plasma membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01973"
] | [
"TNFACTORR27"
] | [
571
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5669034",
"R-MMU-5669034"
] | [
"REACTOME:R-HSA-5669034",
"REACTOME:R-MMU-5669034"
] | 2 | [] | 0 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053600",
"PUB00053601"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"15280356",
"17362907"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
1998,
2004,
2007
] | 8 | [
"IPR047526"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
571
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3
] | 3 | true | Family | Tumour necrosis factor receptor 27 | Tumour necrosis factor receptor 27 | TNFR_27 | 9 |
IPR022320 | 22,320 | Tumour necrosis factor receptor 17 | TNFR_17 | Family | 340 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of ... | [
"GO:0038023",
"GO:0033209"
] | [
"signaling receptor activity",
"tumor necrosis factor-mediated signaling pathway"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PRINTS",
"CDD"
] | [
"PIRSF011859",
"PR01967",
"cd13414"
] | [
"BCMA_Tall-1_bd",
"TNFACTORR17",
"TNFRSF17"
] | [
9,
336,
197
] | 3 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5669034",
"R-MMU-5669034"
] | [
"REACTOME:R-HSA-5669034",
"REACTOME:R-MMU-5669034"
] | 2 | [] | 0 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046034",
"PUB00053608",
"PUB00053609"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826574",
"14764606",
"8165126"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
2004,
1994
] | 7 | [
"IPR043521"
] | [] | 1 | 0 | 1 | [
"Tetrapoda"
] | [
340
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2
] | 3 | true | Family | Tumour necrosis factor receptor 17 | Tumour necrosis factor receptor 17 | TNFR_17 | 5 |
IPR022321 | 22,321 | Insulin-like growth factor-binding protein family 1-6, chordata | IGFBP_1-6_chordata | Family | 5,958 | false | false | Insulin-like growth factors (IGFs)-I and -II are small secreted peptides that stimulate the survival, and promote the proliferation and differentiation, of many cell types [ ]. In biological fluids, these growth factors are usually bound to IGF-binding proteins (IGFBPs), which regulate their availability and activity b... | [
"GO:0005520",
"GO:0005576"
] | [
"insulin-like growth factor binding",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01976"
] | [
"IGFBPFAMILY"
] | [
5958
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-381426",
"R-BTA-6803211",
"R-BTA-8957275",
"R-DRE-381426",
"R-HSA-380994",
"R-HSA-381426",
"R-HSA-6803211",
"R-HSA-8957275",
"R-HSA-9615017",
"R-MMU-381426",
"R-MMU-6803211",
"R-MMU-8957275",
"R-RNO-381426",
"R-RNO-6803211",
"R-RNO-8957275",
"R-SSC-381426",
"R-XTR-381426"
] | [
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-6803211",
"REACTOME:R-BTA-8957275",
"REACTOME:R-DRE-381426",
"REACTOME:R-HSA-380994",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-6803211",
"REACTOME:R-HSA-8957275",
"REACTOME:R-HSA-9615017",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-6803211",
"REACTOME:R-M... | 17 | [
"1boe",
"1h59",
"1rmj",
"1wqj",
"1zt3",
"1zt5",
"2dsp",
"2dsq",
"2dsr",
"2h7t",
"7ufg",
"7wrq"
] | 12 | [
"PUB00053602",
"PUB00053603",
"PUB00053604",
"PUB00053605",
"PUB00053606",
"PUB00053607"
] | [
"8874492",
"10605625",
"7504671",
"7499327",
"7544787",
"9115291"
] | [
"Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors.",
"The insulin-like growth factor-binding protein (IGFBP) superfamily.",
"Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.",
"Heparin modula... | [
1996,
1999,
1993,
1995,
1995,
1997
] | 6 | [] | [
"IPR012210",
"IPR012211",
"IPR012213",
"IPR022322",
"IPR022326",
"IPR022327"
] | 0 | 6 | 0 | [
"Bilateria"
] | [
5958
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
31,
15,
20
] | 4 | true | Family | Insulin-like growth factor-binding protein family 1-6, chordata | Insulin-like growth factor-binding protein family 1-6, chordata | IGFBP_1-6_chordata | 2 |
IPR022322 | 22,322 | Insulin-like growth factor-binding protein 1 | IGFBP1 | Family | 1,058 | false | false | Insulin-like growth factors (IGFs)-I and -II are small secreted peptides that stimulate the survival, and promote the proliferation and differentiation, of many cell types [ ]. In biological fluids, these growth factors are usually bound to IGF binding proteins (IGFBPs), which regulate their availability and activity b... | [
"GO:0005520",
"GO:0005576"
] | [
"insulin-like growth factor binding",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01977"
] | [
"IGFBPFAMILY1"
] | [
1058
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-381426",
"R-BTA-8957275",
"R-HSA-380994",
"R-HSA-381426",
"R-HSA-8957275",
"R-HSA-9615017",
"R-MMU-381426",
"R-MMU-8957275",
"R-RNO-381426",
"R-RNO-8957275"
] | [
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-HSA-380994",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275",
"REACTOME:R-HSA-9615017",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-8957275",
"REACTOME:R-RNO-381426",
"REACTOME:R-RNO-8957275"
] | 10 | [
"1zt3",
"1zt5",
"2dsq"
] | 3 | [
"PUB00053602",
"PUB00053603",
"PUB00053604",
"PUB00053605",
"PUB00053606",
"PUB00053607",
"PUB00053610",
"PUB00053611"
] | [
"8874492",
"10605625",
"7504671",
"7499327",
"7544787",
"9115291",
"7505470",
"12511596"
] | [
"Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors.",
"The insulin-like growth factor-binding protein (IGFBP) superfamily.",
"Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.",
"Heparin modula... | [
1996,
1999,
1993,
1995,
1995,
1997,
1993,
2003
] | 8 | [
"IPR022321"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
1058
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
5,
1,
3
] | 4 | true | Family | Insulin-like growth factor-binding protein 1 | Insulin-like growth factor-binding protein 1 | IGFBP1 | 7 |
IPR022323 | 22,323 | Tumour necrosis factor receptor 11 | TNFR_11 | Family | 776 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01961"
] | [
"TNFACTORR11"
] | [
776
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5669034",
"R-HSA-5668541",
"R-HSA-5669034",
"R-HSA-5676594",
"R-MMU-5668541",
"R-MMU-5669034",
"R-MMU-5676594",
"R-RNO-5669034"
] | [
"REACTOME:R-BTA-5669034",
"REACTOME:R-HSA-5668541",
"REACTOME:R-HSA-5669034",
"REACTOME:R-HSA-5676594",
"REACTOME:R-MMU-5668541",
"REACTOME:R-MMU-5669034",
"REACTOME:R-MMU-5676594",
"REACTOME:R-RNO-5669034"
] | 8 | [
"3urf",
"4e4d"
] | 2 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053612",
"PUB00053613"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"9878548",
"11485016"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
1998,
1998,
2001
] | 8 | [] | [
"IPR017371"
] | 0 | 1 | 0 | [
"Gnathostomata"
] | [
776
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
5
] | 3 | true | Family | Tumour necrosis factor receptor 11 | Tumour necrosis factor receptor 11 | TNFR_11 | 4 |
IPR022324 | 22,324 | Bacilysin exporter BacE, putative | Bacilysin_exporter_BacE_put | Family | 6,473 | false | false | The so-called putative bacilysin exporter, bacE, part of the bacilysin biosynthesis operon, has been shown to be involved in self-protection to bacilysin [ ] by permitting efflux of this antibiotic. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR01988"
] | [
"EXPORTERBACE"
] | [
6473
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007278",
"PUB00007279",
"PUB00053614"
] | [
"9529885",
"9868370",
"15609023"
] | [
"Major facilitator superfamily.",
"Sugar transporters from bacteria, parasites and mammals: structure-activity relationships.",
"bac genes for recombinant bacilysin and anticapsin production in Bacillus host strains."
] | [
1998,
1998,
2005
] | 3 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
57,
6235,
92,
89
] | 4 | [] | [] | 0 | true | Family | Bacilysin exporter BacE, putative | Bacilysin exporter BacE, putative | Bacilysin_exporter_BacE_put | 8 |
IPR022325 | 22,325 | Tumour necrosis factor receptor 16 | TNFR_16 | Family | 1,085 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01966"
] | [
"TNFACTORR16"
] | [
1085
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-GGA-193692",
"R-GGA-205017",
"R-GGA-205043",
"R-GGA-209543",
"R-GGA-209560",
"R-GGA-209563",
"R-HSA-193634",
"R-HSA-193648",
"R-HSA-193670",
"R-HSA-193681",
"R-HSA-193692",
"R-HSA-205017",
"R-HSA-205025",
"R-HSA-205043",
"R-HSA-209543",
"R-HSA-209560",
"R-HSA-209563",
"R-MMU-193... | [
"REACTOME:R-GGA-193692",
"REACTOME:R-GGA-205017",
"REACTOME:R-GGA-205043",
"REACTOME:R-GGA-209543",
"REACTOME:R-GGA-209560",
"REACTOME:R-GGA-209563",
"REACTOME:R-HSA-193634",
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-193670",
"REACTOME:R-HSA-193681",
"REACTOME:R-HSA-193692",
"REACTOME:R-HSA-205... | 33 | [
"1sg1",
"3buk",
"3ij2"
] | 3 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053615",
"PUB00053616"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"18199491",
"17716721"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
1998,
2008,
2007
] | 8 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1085
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
2,
4
] | 4 | true | Family | Tumour necrosis factor receptor 16 | Tumour necrosis factor receptor 16 | TNFR_16 | 4 |
IPR022326 | 22,326 | Insulin-like growth factor-binding protein 6 | IGFBP-6 | Family | 414 | false | false | Insulin-like growth factors (IGFs)-I and -II are small secreted peptides that stimulate the survival, and promote the proliferation and differentiation, of many cell types [ ]. In biological fluids, these growth factors are usually bound to IGF binding proteins (IGFBPs), which regulate their availability and activity b... | [
"GO:0005520",
"GO:0005576"
] | [
"insulin-like growth factor binding",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01982"
] | [
"IGFBPFAMILY6"
] | [
414
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-381426",
"R-MMU-381426",
"R-RNO-381426"
] | [
"REACTOME:R-HSA-381426",
"REACTOME:R-MMU-381426",
"REACTOME:R-RNO-381426"
] | 3 | [
"1rmj"
] | 1 | [
"PUB00053602",
"PUB00053603",
"PUB00053604",
"PUB00053605",
"PUB00053606",
"PUB00053607",
"PUB00053617"
] | [
"8874492",
"10605625",
"7504671",
"7499327",
"7544787",
"9115291",
"10980619"
] | [
"Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors.",
"The insulin-like growth factor-binding protein (IGFBP) superfamily.",
"Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.",
"Heparin modula... | [
1996,
1999,
1993,
1995,
1995,
1997,
2000
] | 7 | [
"IPR022321"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
414
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
1,
2
] | 4 | true | Family | Insulin-like growth factor-binding protein 6 | Insulin-like growth factor-binding protein 6 | IGFBP-6 | 8 |
IPR022327 | 22,327 | Insulin-like growth factor-binding protein 4 | IGFBP-4 | Family | 747 | false | false | Insulin-like growth factors (IGFs)-I and -II are small secreted peptides that stimulate the survival, and promote the proliferation and differentiation, of many cell types [ ]. In biological fluids, these growth factors are usually bound to IGF binding proteins (IGFBPs), which regulate their availability and activity b... | [
"GO:0005520",
"GO:0005576"
] | [
"insulin-like growth factor binding",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01980"
] | [
"IGFBPFAMILY4"
] | [
747
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-381426",
"R-BTA-8957275",
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-8957275",
"R-RNO-381426",
"R-RNO-8957275"
] | [
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-8957275",
"REACTOME:R-RNO-381426",
"REACTOME:R-RNO-8957275"
] | 8 | [] | 0 | [
"PUB00053602",
"PUB00053603",
"PUB00053604",
"PUB00053605",
"PUB00053606",
"PUB00053607",
"PUB00053618"
] | [
"8874492",
"10605625",
"7504671",
"7499327",
"7544787",
"9115291",
"18528331"
] | [
"Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors.",
"The insulin-like growth factor-binding protein (IGFBP) superfamily.",
"Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.",
"Heparin modula... | [
1996,
1999,
1993,
1995,
1995,
1997,
2008
] | 7 | [
"IPR022321"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
747
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
4
] | 3 | true | Family | Insulin-like growth factor-binding protein 4 | Insulin-like growth factor-binding protein 4 | IGFBP-4 | 1 |
IPR022328 | 22,328 | Tumour necrosis factor receptor 7 | TNFR_7 | Family | 247 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a... | [
"GO:0004888",
"GO:0043066",
"GO:0045579",
"GO:0045582"
] | [
"transmembrane signaling receptor activity",
"negative regulation of apoptotic process",
"positive regulation of B cell differentiation",
"positive regulation of T cell differentiation"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process"
] | 4 | [
"PRINTS"
] | [
"PR01960"
] | [
"TNFACTORR7"
] | [
247
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5669034",
"R-MMU-5669034"
] | [
"REACTOME:R-HSA-5669034",
"REACTOME:R-MMU-5669034"
] | 2 | [] | 0 | [
"PUB00000892",
"PUB00011475",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053619"
] | [
"8387891",
"9177220",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"11062504"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.",
"Tumor necrosis factor receptor superfamily members and thei... | [
1993,
1997,
1994,
2004,
2001,
1998,
1998,
2000
] | 8 | [] | [] | 0 | 0 | null | [
"Eutheria"
] | [
247
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
6
] | 3 | true | Family | Tumour necrosis factor receptor 7 | Tumour necrosis factor receptor 7 | TNFR_7 | 9 |
IPR022329 | 22,329 | Tumour necrosis factor receptor 25 | TNFR_25 | Family | 969 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain- a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a... | [] | [] | [] | 0 | [
"PRINTS",
"PANTHER"
] | [
"PR01972",
"PTHR47220"
] | [
"TNFACTORR25",
""
] | [
590,
966
] | 2 | [
"REACTOME"
] | [
"R-HSA-5669034"
] | [
"REACTOME:R-HSA-5669034"
] | 1 | [] | 0 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053629",
"PUB00053630"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"9615223",
"11313471"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
1998,
1998,
2001
] | 8 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
969
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
3,
5
] | 3 | true | Family | Tumour necrosis factor receptor 25 | Tumour necrosis factor receptor 25 | TNFR_25 | 5 |
IPR022330 | 22,330 | Tumour necrosis factor receptor 21 | TNFR_21 | Family | 1,039 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a... | [] | [] | [] | 0 | [
"PRINTS",
"PANTHER"
] | [
"PR01971",
"PTHR46921"
] | [
"TNFACTORR21",
""
] | [
946,
1039
] | 2 | [
"REACTOME"
] | [
"R-HSA-1989781"
] | [
"REACTOME:R-HSA-1989781"
] | 1 | [
"2dbh",
"3qo4",
"3u3p",
"3u3q",
"3u3s",
"3u3t",
"3u3v",
"4yn0"
] | 8 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053620",
"PUB00082372",
"PUB00153341"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"19760075",
"21463639",
"34012073"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
1998,
2009,
2011,
2021
] | 9 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1039
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
3,
1
] | 4 | true | Family | Tumour necrosis factor receptor 21 | Tumour necrosis factor receptor 21 | TNFR_21 | 2 |
IPR022332 | 22,332 | Tumour necrosis factor receptor 14 | TNFR_14 | Family | 256 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01965"
] | [
"TNFACTORR14"
] | [
256
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5669034",
"R-HSA-9927353",
"R-MMU-5669034",
"R-MMU-9927353"
] | [
"REACTOME:R-HSA-5669034",
"REACTOME:R-HSA-9927353",
"REACTOME:R-MMU-5669034",
"REACTOME:R-MMU-9927353"
] | 4 | [
"1jma",
"2aw2",
"3wvt",
"4fhq",
"4rsu",
"5t2q",
"5t2r",
"6ng3",
"7msg",
"7msj"
] | 10 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053628"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"8898196"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
1998,
1996
] | 7 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
256
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
7,
3
] | 3 | true | Family | Tumour necrosis factor receptor 14 | Tumour necrosis factor receptor 14 | TNFR_14 | 1 |
IPR022334 | 22,334 | Insulin-like growth factor II | IGF2 | Family | 1,206 | false | false | The IGFs, or somatomedins, play a key role in pre-adolescent mammalian growth. IGF2 appears to be induced by placental lactogen and is thought to play a role in foetal development [ ]. The insulin/IGF/relaxin superfamily is an ancient family of functionally diverse proteins [ ]. The 3D structures of a number of family ... | [
"GO:0008083",
"GO:0005615"
] | [
"growth factor activity",
"extracellular space"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR02006"
] | [
"INSLNLIKEGF2"
] | [
1206
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-2404192",
"R-BTA-2428928",
"R-BTA-2428933",
"R-BTA-381426",
"R-GGA-114608",
"R-GGA-2404192",
"R-GGA-2428928",
"R-GGA-2428933",
"R-GGA-381426",
"R-HSA-114608",
"R-HSA-2404192",
"R-HSA-2428928",
"R-HSA-2428933",
"R-HSA-381426",
"R-MMU-114608",
"R-MMU-2404192",
... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-2404192",
"REACTOME:R-BTA-2428928",
"REACTOME:R-BTA-2428933",
"REACTOME:R-BTA-381426",
"REACTOME:R-GGA-114608",
"REACTOME:R-GGA-2404192",
"REACTOME:R-GGA-2428928",
"REACTOME:R-GGA-2428933",
"REACTOME:R-GGA-381426",
"REACTOME:R-HSA-114608",
"REACTOME:R-H... | 30 | [
"1igl",
"2l29",
"2v5p",
"3e4z",
"3kr3",
"5l3l",
"5l3m",
"5l3n",
"6um2",
"6vwg",
"6vwi",
"8u4c",
"8u4e",
"8vjb",
"8vjc",
"8ysz"
] | 16 | [
"PUB00003970",
"PUB00003972",
"PUB00003973",
"PUB00023078",
"PUB00037375",
"PUB00053639",
"PUB00053640",
"PUB00053641",
"PUB00053642",
"PUB00053643",
"PUB00096674"
] | [
"503234",
"6243748",
"6107857",
"2036417",
"9141131",
"10601981",
"8735594",
"8683595",
"1319992",
"6382022",
"30747102"
] | [
"Nucleotide sequence of a cDNA clone encoding human preproinsulin.",
"Sequence of the human insulin gene.",
"Hormone families: pancreatic hormones and homologous growth factors.",
"Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.",... | [
1979,
1980,
1980,
1991,
1997,
1999,
1996,
1996,
1992,
1984,
2019
] | 11 | [
"IPR022350"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1206
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
2,
9
] | 4 | true | Family | Insulin-like growth factor II | Insulin-like growth factor II | IGF2 | 2 |
IPR022335 | 22,335 | G protein-coupled receptor 153 | GPR153 | Family | 544 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004930",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01992"
] | [
"GPR153"
] | [
544
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053632",
"PUB00053633",
"PUB00053634",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00063901",
"PUB00063902"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"9445485",
"9074930",
"8723724",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"15777626",
"21981325"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its synt... | [
1990,
1988,
1993,
1994,
1998,
1997,
1996,
2003,
1994,
2005,
2009,
2006,
2013,
2005,
2011
] | 15 | [
"IPR022347"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
544
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
2,
3
] | 4 | true | Family | G protein-coupled receptor 153 | G protein-coupled receptor 153 | GPR153 | 9 |
IPR022336 | 22,336 | Neurogenic locus notch homolog protein 2 | Notch_2 | Family | 881 | false | false | Notch cell surface receptors are large, single-pass type-1 transmembrane proteins found in a diverse range of metazoan species, from human to Caenorhabditis species. The fruit fly, Drosophila melanogaster, possesses only one Notch protein, whereas in C.elegans, two receptors have been found; by contrast, four Notch par... | [
"GO:0038023",
"GO:0006355",
"GO:0006915",
"GO:0007219",
"GO:0071228",
"GO:0043235"
] | [
"signaling receptor activity",
"regulation of DNA-templated transcription",
"apoptotic process",
"Notch signaling pathway",
"cellular response to tumor cell",
"receptor complex"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 6 | [
"PRINTS"
] | [
"PR01985"
] | [
"NOTCH2"
] | [
881
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1912399",
"R-HSA-1912408",
"R-HSA-1912420",
"R-HSA-2197563",
"R-HSA-2979096",
"R-HSA-350054",
"R-HSA-5083630",
"R-HSA-9013695"
] | [
"REACTOME:R-HSA-1912399",
"REACTOME:R-HSA-1912408",
"REACTOME:R-HSA-1912420",
"REACTOME:R-HSA-2197563",
"REACTOME:R-HSA-2979096",
"REACTOME:R-HSA-350054",
"REACTOME:R-HSA-5083630",
"REACTOME:R-HSA-9013695"
] | 8 | [] | 0 | [
"PUB00013432",
"PUB00053622",
"PUB00053623",
"PUB00053624",
"PUB00053625",
"PUB00053626",
"PUB00053638",
"PUB00076422",
"PUB00100055",
"PUB00100056",
"PUB00100057",
"PUB00100058",
"PUB00100059"
] | [
"10221902",
"19379690",
"12354787",
"11101851",
"12668592",
"16429119",
"10206645",
"25985737",
"18710934",
"29149593",
"10393120",
"21378989",
"21378985"
] | [
"Notch signaling: cell fate control and signal integration in development.",
"The canonical Notch signaling pathway: unfolding the activation mechanism.",
"The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.",
"MAML1, a human homologue... | [
1999,
2009,
2002,
2000,
2003,
2006,
1999,
2015,
2008,
2017,
1999,
2011,
2011
] | 13 | [
"IPR008297"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
881
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
3,
5
] | 4 | true | Family | Neurogenic locus notch homolog protein 2 | Neurogenic locus notch homolog protein 2 | Notch_2 | 1 |
IPR022337 | 22,337 | Inositol monophosphatase SuhB-like | Inositol_monophosphatase_SuhB | Family | 12,253 | false | false | This entry represents a group of inositol monophosphatases (IMPases) mainly from bacteria. E. coli SuhB is part of the rRNA transcription anti-termination complex (rrnTAC) that prevents rho-dependent termination. The rrnTAC consists of Nus factors A, B, E and G, ribosomal protein S4 and inositol mono-phosphatase SuhB. ... | [
"GO:0008934"
] | [
"inositol monophosphate 1-phosphatase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01959"
] | [
"SBIMPHPHTASE"
] | [
12253
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.1.3.25",
"PWY-2301",
"PWY-4702",
"PWY-6363"
] | [
"EC:3.1.3.25",
"METACYC:PWY-2301",
"METACYC:PWY-4702",
"METACYC:PWY-6363"
] | 4 | [
"2pcr",
"2qfl",
"3luz",
"3lv0",
"5zhh",
"6ib7",
"6ib8",
"6tqn",
"6tqo",
"8wdq",
"8wip",
"9j90",
"9jfc",
"9mmi"
] | 14 | [
"PUB00000822",
"PUB00004864",
"PUB00026064",
"PUB00032773",
"PUB00046132",
"PUB00053644",
"PUB00053645",
"PUB00095608",
"PUB00095610"
] | [
"2553271",
"7761465",
"8068621",
"15858264",
"10822345",
"10747806",
"8002619",
"17652087",
"31020314"
] | [
"Neural and developmental actions of lithium: a unifying hypothesis.",
"Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure.",
"Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catal... | [
1989,
1995,
1994,
2005,
2000,
2000,
1995,
2007,
2019
] | 9 | [
"IPR033942"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"unclassified sequences"
] | [
11997,
5,
72,
179
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Inositol monophosphatase SuhB-like | Inositol monophosphatase SuhB-like | Inositol_monophosphatase_SuhB | 6 |
IPR022338 | 22,338 | Tumour necrosis factor receptor 13C | TNFR_13C | Family | 344 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of a... | [
"GO:0038023",
"GO:0033209"
] | [
"signaling receptor activity",
"tumor necrosis factor-mediated signaling pathway"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR01964"
] | [
"TNFACTORR13C"
] | [
344
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5668541",
"R-HSA-5676594",
"R-MMU-5668541",
"R-MMU-5676594"
] | [
"REACTOME:R-HSA-5668541",
"REACTOME:R-HSA-5676594",
"REACTOME:R-MMU-5668541",
"REACTOME:R-MMU-5676594"
] | 4 | [
"8zuk"
] | 1 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053646",
"PUB00053647"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"11509692",
"17073941"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
1998,
2001,
2007
] | 8 | [
"IPR043521"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
344
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
5,
1
] | 3 | true | Family | Tumour necrosis factor receptor 13C | Tumour necrosis factor receptor 13C | TNFR_13C | 3 |
IPR022339 | 22,339 | MHC class II-associated invariant chain | MHC_II-assoc_invar_chain | Family | 1,121 | false | false | The CD74 antigen (also known as H-2 class II histocompatibility antigen gamma chain, MHC class II-associated invariant chain, Ia antigen-associated invariant chain, or Ii) plays a key role in MHC class II antigen processing: it stabilises peptide-free class II alpha/beta heterodimers in a nonameric (α-β-gamma)3 complex... | [
"GO:0042289",
"GO:0019882",
"GO:0016020"
] | [
"MHC class II protein binding",
"antigen processing and presentation",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01990"
] | [
"CD74ANTIGEN"
] | [
1121
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-202733",
"R-HSA-2132295",
"R-HSA-9925563",
"R-MMU-202733",
"R-MMU-2132295",
"R-RNO-202733",
"R-RNO-2132295"
] | [
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-2132295",
"REACTOME:R-HSA-9925563",
"REACTOME:R-MMU-202733",
"REACTOME:R-MMU-2132295",
"REACTOME:R-RNO-202733",
"REACTOME:R-RNO-2132295"
] | 7 | [
"1iie",
"8vrw",
"8vsp"
] | 3 | [
"PUB00011780"
] | [
"9843486"
] | [
"Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Pseudomonadati"
] | [
1119,
2
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
9
] | 3 | true | Family | MHC class II-associated invariant chain | MHC class II-associated invariant chain | MHC_II-assoc_invar_chain | 2 |
IPR022340 | 22,340 | G protein-coupled receptor GCR1 putative | GPCR_GCR1_put | Family | 1,103 | false | false | Heterotrimeric G protein-mediated signalling via activated 7-transmembrane (7TM) serpentine receptors is well known in a range of organisms, but evidence for the existence of this pathway in plants has been elusive. Over the years, however, evidence that G proteins are involved in signal transduction in plants has been... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02000"
] | [
"GCR1PLANT"
] | [
1103
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053651",
"PUB00053652"
] | [
"9370348",
"9512416"
] | [
"Cloning of a putative G-protein-coupled receptor from Arabidopsis thaliana.",
"A higher plant seven-transmembrane receptor that influences sensitivity to cytokinins."
] | [
1997,
1998
] | 2 | [
"IPR022343"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1103
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
2,
9
] | 3 | true | Family | G protein-coupled receptor GCR1 putative | G protein-coupled receptor GCR1 putative | GPCR_GCR1_put | 8 |
IPR022341 | 22,341 | Insulin-like growth factor I | IGF-I | Family | 1,724 | false | false | The IGFs, or somatomedins, play a key role in pre-adolescent mammalian growth. IGFI expression is regulated by growth hormone and mediates post-natal growth [ ]. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency), an autosomal recessive disorder characterised by growth retardatio... | [
"GO:0008083",
"GO:0005615"
] | [
"growth factor activity",
"extracellular space"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR02005"
] | [
"INSLNLIKEGF1"
] | [
1724
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-2404192",
"R-BTA-2428928",
"R-BTA-2428933",
"R-BTA-381426",
"R-BTA-422085",
"R-CFA-114608",
"R-CFA-2404192",
"R-CFA-2428928",
"R-CFA-2428933",
"R-CFA-381426",
"R-CFA-422085",
"R-GGA-114608",
"R-GGA-2404192",
"R-GGA-2428928",
"R-GGA-2428933",
"R-GGA-381426",
"... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-2404192",
"REACTOME:R-BTA-2428928",
"REACTOME:R-BTA-2428933",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-422085",
"REACTOME:R-CFA-114608",
"REACTOME:R-CFA-2404192",
"REACTOME:R-CFA-2428928",
"REACTOME:R-CFA-2428933",
"REACTOME:R-CFA-381426",
"REACTOME:R-C... | 42 | [
"1bqt",
"1gzr",
"1gzy",
"1gzz",
"1h02",
"1h59",
"1imx",
"1pmx",
"1wqj",
"2dsp",
"2dsq",
"2dsr",
"2gf1",
"3gf1",
"3lri",
"4xss",
"5u8q",
"6ff3",
"6pyh",
"6rva",
"7s0q",
"7wrq",
"7yrr",
"8eyr",
"8x06",
"8x2m",
"8xjs",
"8xk1",
"8xkm",
"8xkr"
] | 30 | [
"PUB00003970",
"PUB00003972",
"PUB00003973",
"PUB00023078",
"PUB00037375",
"PUB00053639",
"PUB00053640",
"PUB00053641",
"PUB00053642",
"PUB00053643",
"PUB00053653",
"PUB00096674"
] | [
"503234",
"6243748",
"6107857",
"2036417",
"9141131",
"10601981",
"8735594",
"8683595",
"1319992",
"6382022",
"8857020",
"30747102"
] | [
"Nucleotide sequence of a cDNA clone encoding human preproinsulin.",
"Sequence of the human insulin gene.",
"Hormone families: pancreatic hormones and homologous growth factors.",
"Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.",... | [
1979,
1980,
1980,
1991,
1997,
1999,
1996,
1996,
1992,
1984,
1996,
2019
] | 12 | [
"IPR022350"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1724
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
8,
14
] | 4 | true | Family | Insulin-like growth factor I | Insulin-like growth factor I | IGF-I | 7 |
IPR022342 | 22,342 | Tumour necrosis factor receptor 19 | TNFR_19 | Family | 925 | false | false | TNF receptor 19, also known as toxicity and JNK inducer (TAJ) and TROY, is highly expressed during embryonic development, where it may act as a regulator of cell activation and cell death [ ]. In adult tissues, the receptor is expressed in the central nervous system, and may mediate the inhibitory effects of myelin upo... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01969"
] | [
"TNFACTORR19"
] | [
925
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053654",
"PUB00053655"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"10809768",
"15694321"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
1998,
2000,
2005
] | 8 | [
"IPR047526"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
925
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
3,
2
] | 4 | true | Family | Tumour necrosis factor receptor 19 | Tumour necrosis factor receptor 19 | TNFR_19 | 8 |
IPR022343 | 22,343 | GCR1-cAMP receptor | GCR1-cAMP_receptor | Family | 3,738 | false | false | Heterotrimeric G protein-mediated signalling via activated 7-transmembrane (7TM) serpentine receptors is well known in a range of organisms, but evidence for the existence of this pathway in plants has been elusive. Over the years, however, evidence that G proteins are involved in signal transduction in plants has been... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02001"
] | [
"GCR1CAMPR"
] | [
3738
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001912",
"PUB00001913",
"PUB00005114",
"PUB00053651",
"PUB00053652"
] | [
"8436297",
"8382181",
"3047871",
"9370348",
"9512416"
] | [
"CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum.",
"Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development.",
"A chemoattractant receptor controls developme... | [
1993,
1993,
1988,
1997,
1998
] | 5 | [] | [
"IPR022340"
] | 0 | 1 | 0 | [
"Eukaryota"
] | [
3738
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
7,
2,
7,
4,
2,
2,
9
] | 8 | true | Family | GCR1-cAMP receptor | GCR1-cAMP receptor | GCR1-cAMP_receptor | 6 |
IPR022344 | 22,344 | Gene transfer agent, major tail protein | GTA_major-tail | Family | 1,743 | false | false | Gene transfer agents belong to a group of unusual genetic exchange elements [ ]. GTAs are unusual in the sense they have the structure of a small tailed phage, which do not possess typical phage traits such as host cell lysis and infectious transmission of the GTA genes. In the Rhodobacter capsulatus GTA the GTA partic... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01996"
] | [
"MTP1FAMILY"
] | [
1743
] | 1 | [] | [] | [] | 0 | [
"6tba",
"6te9",
"6tea",
"6teb",
"6toa",
"6tsv",
"6tui"
] | 7 | [
"PUB00055430",
"PUB00055431"
] | [
"11382219",
"12399927"
] | [
"The gene transfer agent of Rhodobacter capsulatus and \"constitutive transduction\" in prokaryotes.",
"Evolutionary implications of phylogenetic analyses of the gene transfer agent (GTA) of Rhodobacter capsulatus."
] | [
2001,
2002
] | 2 | [
"IPR011855"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Ecdysozoa",
"Viruses",
"metagenomes"
] | [
1713,
2,
11,
17
] | 4 | [] | [] | 0 | true | Family | Gene transfer agent, major tail protein | Gene transfer agent, major tail protein | GTA_major-tail | 2 |
IPR022345 | 22,345 | Bacteriophage 69, Orf23, major tail protein | Phage_69_Orf23_MTP | Family | 572 | false | false | This entry is represented by Bacteriophage 69, Orf23, the major tail protein. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01997"
] | [
"MTP2FAMILY"
] | [
572
] | 1 | [] | [] | [] | 0 | [
"6v8i",
"9mu2",
"9mu3"
] | 3 | [] | [] | [] | [] | 0 | [
"IPR011855"
] | [
"IPR022363"
] | 1 | 1 | 0 | [
"Bacteria",
"Viruses",
"metagenomes"
] | [
446,
124,
2
] | 3 | [] | [] | 0 | true | Family | Bacteriophage 69, Orf23, major tail protein | Bacteriophage 69, Orf23, major tail protein | Phage_69_Orf23_MTP | 4 |
IPR022346 | 22,346 | General secretion pathway, GspH | T2SS_GspH | Domain | 12,663 | false | false | GspH is involved in bacterial type II export systems [ ]. Like all pilins, GspH has an N terminus α helix [ ]. This helix is followed by nine β strands forming two β sheets, one of five antiparallel strands and one of four antiparallel strands [ ]. GspH is a minor pseudopilin; it is expressed much less than other pseud... | [
"GO:0015628",
"GO:0015627"
] | [
"protein secretion by the type II secretion system",
"type II protein secretion system complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF12019"
] | [
"GspH"
] | [
12663
] | 1 | [] | [] | [] | 0 | [
"2knq",
"2qv8",
"4dq9",
"4ipu",
"4ipv",
"7qyi"
] | 6 | [
"PUB00049160"
] | [
"18241884"
] | [
"Structure of the minor pseudopilin EpsH from the Type 2 secretion system of Vibrio cholerae."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
12469,
11,
183
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | General secretion pathway, GspH | General secretion pathway, GspH | T2SS_GspH | 7 |
IPR022347 | 22,347 | G protein-coupled receptor 153/162 | GCR_153/162 | Family | 1,325 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004930",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"PANTHER"
] | [
"PR01991",
"PTHR16518"
] | [
"GPR153GPR162",
""
] | [
1217,
1315
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053632",
"PUB00053633",
"PUB00053634",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00063901",
"PUB00063902"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"9445485",
"9074930",
"8723724",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"15777626",
"21981325"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its synt... | [
1990,
1988,
1993,
1994,
1998,
1997,
1996,
2003,
1994,
2005,
2009,
2006,
2013,
2005,
2011
] | 15 | [
"IPR000276"
] | [
"IPR022335",
"IPR022348"
] | 1 | 2 | 0 | [
"Bacteria",
"Bilateria"
] | [
9,
1316
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
9,
4,
6
] | 4 | true | Family | G protein-coupled receptor 153/162 | G protein-coupled receptor 153/162 | GCR_153/162 | 1 |
IPR022348 | 22,348 | G protein-coupled receptor 162 | GPR162 | Family | 659 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0004930",
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01993"
] | [
"GPR162"
] | [
659
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053632",
"PUB00053633",
"PUB00053634",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00063901",
"PUB00063902"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"9445485",
"9074930",
"8723724",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"15777626",
"21981325"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its synt... | [
1990,
1988,
1993,
1994,
1998,
1997,
1996,
2003,
1994,
2005,
2009,
2006,
2013,
2005,
2011
] | 15 | [
"IPR022347"
] | [] | 1 | 0 | 1 | [
"Actinomycetes",
"Eukaryota",
"uncultured Caudovirales phage"
] | [
2,
656,
1
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
2,
3
] | 3 | true | Family | G protein-coupled receptor 162 | G protein-coupled receptor 162 | GPR162 | 8 |
IPR022350 | 22,350 | Insulin-like growth factor IGF-1/2 | IGF-1/2 | Family | 2,889 | false | false | This entry represents insulin-like growth factors, IGF-1/2, found in animals. IGF-1 and IGF-2 are peptide hormones structurally similar to insulin and play essential roles in growth and development. Both IGFs bind to IGF receptors, primarily IGF-1R, activating intracellular signaling pathways that regulate cell surviva... | [
"GO:0005179",
"GO:0008083",
"GO:0005615"
] | [
"hormone activity",
"growth factor activity",
"extracellular space"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR02002"
] | [
"INSLNLIKEGF"
] | [
2889
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-2404192",
"R-BTA-2428928",
"R-BTA-2428933",
"R-BTA-381426",
"R-BTA-422085",
"R-CFA-114608",
"R-CFA-2404192",
"R-CFA-2428928",
"R-CFA-2428933",
"R-CFA-381426",
"R-CFA-422085",
"R-GGA-114608",
"R-GGA-2404192",
"R-GGA-2428928",
"R-GGA-2428933",
"R-GGA-381426",
"... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-2404192",
"REACTOME:R-BTA-2428928",
"REACTOME:R-BTA-2428933",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-422085",
"REACTOME:R-CFA-114608",
"REACTOME:R-CFA-2404192",
"REACTOME:R-CFA-2428928",
"REACTOME:R-CFA-2428933",
"REACTOME:R-CFA-381426",
"REACTOME:R-C... | 42 | [
"1bqt",
"1gzr",
"1gzy",
"1gzz",
"1h02",
"1h59",
"1igl",
"1imx",
"1pmx",
"1wqj",
"2dsp",
"2dsq",
"2dsr",
"2gf1",
"2l29",
"2v5p",
"3e4z",
"3gf1",
"3kr3",
"3lri",
"4xss",
"5l3l",
"5l3m",
"5l3n",
"5u8q",
"6ff3",
"6pyh",
"6rva",
"6um2",
"6vwg",
"6vwi",
"7s0q"... | 46 | [
"PUB00003970",
"PUB00003972",
"PUB00003973",
"PUB00023078",
"PUB00037375",
"PUB00053639",
"PUB00053640",
"PUB00053641",
"PUB00053642",
"PUB00053643",
"PUB00053653",
"PUB00096674",
"PUB00160367",
"PUB00160368"
] | [
"503234",
"6243748",
"6107857",
"2036417",
"9141131",
"10601981",
"8735594",
"8683595",
"1319992",
"6382022",
"8857020",
"30747102",
"1713219",
"23382729"
] | [
"Nucleotide sequence of a cDNA clone encoding human preproinsulin.",
"Sequence of the human insulin gene.",
"Hormone families: pancreatic hormones and homologous growth factors.",
"Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.",... | [
1979,
1980,
1980,
1991,
1997,
1999,
1996,
1996,
1992,
1984,
1996,
2019,
1991,
2013
] | 14 | [
"IPR022352"
] | [
"IPR022334",
"IPR022341"
] | 1 | 2 | 0 | [
"Bilateria"
] | [
2889
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
10,
11,
22
] | 4 | true | Family | Insulin-like growth factor IGF-1/2 | Insulin-like growth factor IGF-1/2 | IGF-1/2 | 4 |
IPR022352 | 22,352 | Insulin/IGF/relaxin | Ins/IGF/rlx | Family | 6,912 | false | false | The insulin/IGF/relaxin superfamily is an ancient family of functionally diverse proteins [ ]. The 3D structures of a number of family members have been determined [ , , ]. The fold comprises two polypeptide chains (A and B) linked by two disulphide bonds: all share a conserved arrangement of four cysteines in their A ... | [
"GO:0005179"
] | [
"hormone activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00276"
] | [
"INSULINFAMLY"
] | [
6912
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-2404192",
"R-BTA-2428928",
"R-BTA-2428933",
"R-BTA-381426",
"R-BTA-422085",
"R-CFA-114608",
"R-CFA-2404192",
"R-CFA-2428928",
"R-CFA-2428933",
"R-CFA-264876",
"R-CFA-381426",
"R-CFA-422085",
"R-CFA-6807878",
"R-CFA-6811558",
"R-CFA-74713",
"R-CFA-74749",
"R-C... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-2404192",
"REACTOME:R-BTA-2428928",
"REACTOME:R-BTA-2428933",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-422085",
"REACTOME:R-CFA-114608",
"REACTOME:R-CFA-2404192",
"REACTOME:R-CFA-2428928",
"REACTOME:R-CFA-2428933",
"REACTOME:R-CFA-264876",
"REACTOME:R-C... | 113 | [
"1b9g",
"1bqt",
"1efe",
"1gzr",
"1gzy",
"1gzz",
"1h02",
"1h59",
"1igl",
"1imx",
"1pmx",
"1sju",
"1tgr",
"1wqj",
"1zei",
"2dsp",
"2dsq",
"2dsr",
"2gf1",
"2jzq",
"2kqp",
"2l29",
"2lwz",
"2v5p",
"3e4z",
"3gf1",
"3kr3",
"3lri",
"4xss",
"5l3l",
"5l3m",
"5l3n"... | 87 | [
"PUB00003970",
"PUB00003972",
"PUB00003973",
"PUB00023078",
"PUB00037375",
"PUB00053639",
"PUB00053640",
"PUB00053641",
"PUB00053642",
"PUB00096674"
] | [
"503234",
"6243748",
"6107857",
"2036417",
"9141131",
"10601981",
"8735594",
"8683595",
"1319992",
"30747102"
] | [
"Nucleotide sequence of a cDNA clone encoding human preproinsulin.",
"Sequence of the human insulin gene.",
"Hormone families: pancreatic hormones and homologous growth factors.",
"Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.",... | [
1979,
1980,
1980,
1991,
1997,
1999,
1996,
1996,
1992,
2019
] | 10 | [] | [
"IPR004825",
"IPR017097",
"IPR022350"
] | 0 | 3 | 0 | [
"Alphairidovirinae",
"Brevibacillus brevis",
"Eukaryota"
] | [
2,
1,
6909
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
17,
16,
18,
19,
33
] | 6 | true | Family | Insulin/IGF/relaxin | Insulin/IGF/relaxin | Ins/IGF/rlx | 4 |
IPR022353 | 22,353 | Insulin, conserved site | Insulin_CS | Conserved_site | 8,903 | false | false | This entry describes the insulin and insulin related family signature pattern The pattern is represented by the following sequence: C-C-{P}-{P}-x-C-[STDNEKPI]-x(3)-[LIVMFS]-x(3)-C. Insulin is found in many animals, and is involved in the regulation of normal glucose homeostasis. It also has other specific physiological... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00262"
] | [
"INSULIN"
] | [
8903
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-2404192",
"R-BTA-2428928",
"R-BTA-2428933",
"R-BTA-381426",
"R-BTA-418555",
"R-BTA-422085",
"R-BTA-444821",
"R-CFA-114608",
"R-CFA-2404192",
"R-CFA-2428928",
"R-CFA-2428933",
"R-CFA-264876",
"R-CFA-381426",
"R-CFA-422085",
"R-CFA-444821",
"R-CFA-6807878",
"R-... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-2404192",
"REACTOME:R-BTA-2428928",
"REACTOME:R-BTA-2428933",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-418555",
"REACTOME:R-BTA-422085",
"REACTOME:R-BTA-444821",
"REACTOME:R-CFA-114608",
"REACTOME:R-CFA-2404192",
"REACTOME:R-CFA-2428928",
"REACTOME:R-CF... | 116 | [
"1a7f",
"1ai0",
"1aiy",
"1aph",
"1b17",
"1b18",
"1b19",
"1b2a",
"1b2b",
"1b2c",
"1b2d",
"1b2e",
"1b2f",
"1b2g",
"1b9e",
"1b9g",
"1ben",
"1bom",
"1bon",
"1bph",
"1bqt",
"1bzv",
"1cph",
"1dei",
"1dph",
"1efe",
"1ev3",
"1ev6",
"1evr",
"1fu2",
"1fub",
"1g7a"... | 511 | [
"PUB00003970",
"PUB00003972",
"PUB00003973",
"PUB00023078",
"PUB00037375",
"PUB00053639",
"PUB00053640",
"PUB00053641",
"PUB00053642",
"PUB00096674"
] | [
"503234",
"6243748",
"6107857",
"2036417",
"9141131",
"10601981",
"8735594",
"8683595",
"1319992",
"30747102"
] | [
"Nucleotide sequence of a cDNA clone encoding human preproinsulin.",
"Sequence of the human insulin gene.",
"Hormone families: pancreatic hormones and homologous growth factors.",
"Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.",... | [
1979,
1980,
1980,
1991,
1997,
1999,
1996,
1996,
1992,
2019
] | 10 | [] | [] | 0 | 0 | null | [
"Brevibacillus brevis",
"Eukaryota",
"Singapore grouper iridovirus",
"viral metagenome"
] | [
1,
8899,
2,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
18,
16,
21,
23,
39
] | 6 | true | Conserved_site | Insulin, conserved site | Insulin, conserved site | Insulin_CS | 8 |
IPR022354 | 22,354 | Pheromone-binding protein Gp-9 | Pheromone-bd_protein_Gp-9 | Family | 96 | false | false | The fire ant, Solenopsis invicta, exists in either monogyne or polygyne social forms: the former contains a single reproductive queen, the latter multiple queens. These social behavioural differences are associated with variation at gene Gp-9, colonies bearing only the B allelic variant being monogyne, those bearing bo... | [
"GO:0035176",
"GO:0005615"
] | [
"social behavior",
"extracellular space"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR02007"
] | [
"ODORANTBPGP9"
] | [
96
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053657",
"PUB00053658",
"PUB00053659",
"PUB00053660"
] | [
"15987877",
"15612031",
"11711637",
"17987107"
] | [
"Molecular evolutionary analyses of the odorant-binding protein gene Gp-9 in fire ants and other Solenopsis species.",
"To b or not to b: a pheromone-binding protein regulates colony social organization in fire ants.",
"Identification of a major gene regulating complex social behavior.",
"Molecular variation ... | [
2005,
2005,
2002,
2007
] | 4 | [
"IPR006170"
] | [] | 1 | 0 | 1 | [
"Formicidae"
] | [
96
] | 1 | [] | [] | 0 | true | Family | Pheromone-binding protein Gp-9 | Pheromone-binding protein Gp-9 | Pheromone-bd_protein_Gp-9 | 7 |
IPR022355 | 22,355 | Neurogenic locus Notch 4 | Notch_4 | Family | 335 | false | false | Notch cell surface receptors are large, single-pass type-1 transmembrane proteins found in a diverse range of metazoan species, from human to Caenorhabditis species. The fruit fly, Drosophila melanogaster, possesses only one Notch protein, whereas in C.elegans, two receptors have been found; by contrast, four Notch par... | [
"GO:0038023",
"GO:0006355",
"GO:0007219"
] | [
"signaling receptor activity",
"regulation of DNA-templated transcription",
"Notch signaling pathway"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR01987"
] | [
"NOTCH4"
] | [
335
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1912399",
"R-HSA-1912408",
"R-HSA-1912420",
"R-HSA-350054",
"R-HSA-5083630",
"R-HSA-9013695",
"R-HSA-9013700",
"R-HSA-9604323",
"R-MMU-1912420",
"R-MMU-350054",
"R-MMU-9013700",
"R-MMU-9604323"
] | [
"REACTOME:R-HSA-1912399",
"REACTOME:R-HSA-1912408",
"REACTOME:R-HSA-1912420",
"REACTOME:R-HSA-350054",
"REACTOME:R-HSA-5083630",
"REACTOME:R-HSA-9013695",
"REACTOME:R-HSA-9013700",
"REACTOME:R-HSA-9604323",
"REACTOME:R-MMU-1912420",
"REACTOME:R-MMU-350054",
"REACTOME:R-MMU-9013700",
"REACTOME:... | 12 | [] | 0 | [
"PUB00013432",
"PUB00053622",
"PUB00053623",
"PUB00053624",
"PUB00053625",
"PUB00053626",
"PUB00053638",
"PUB00053661"
] | [
"10221902",
"19379690",
"12354787",
"11101851",
"12668592",
"16429119",
"10206645",
"9189758"
] | [
"Notch signaling: cell fate control and signal integration in development.",
"The canonical Notch signaling pathway: unfolding the activation mechanism.",
"The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.",
"MAML1, a human homologue... | [
1999,
2009,
2002,
2000,
2003,
2006,
1999,
1997
] | 8 | [
"IPR008297"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
335
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
2,
8
] | 3 | true | Family | Neurogenic locus Notch 4 | Neurogenic locus Notch 4 | Notch_4 | 3 |
IPR022357 | 22,357 | Major intrinsic protein, conserved site | MIP_CS | Conserved_site | 60,790 | false | false | This entry represents a conserved region which is located in the cytoplasmic loop between the second and third transmembrane regions of MIP family members. The major intrinsic protein (MIP) family is large and diverse, possessing over 100 members that form transmembrane channels. These channel proteins function in wate... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00221"
] | [
"MIP"
] | [
60790
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1237044",
"R-BTA-1247673",
"R-BTA-432040",
"R-BTA-432047",
"R-CFA-1237044",
"R-CFA-1247673",
"R-CFA-432040",
"R-CFA-432047",
"R-DDI-1237044",
"R-DDI-1247673",
"R-DDI-432040",
"R-DDI-432047",
"R-DME-1237044",
"R-DME-1247673",
"R-DME-432040",
"R-DME-432047",
"R-GGA-432047",
"R... | [
"REACTOME:R-BTA-1237044",
"REACTOME:R-BTA-1247673",
"REACTOME:R-BTA-432040",
"REACTOME:R-BTA-432047",
"REACTOME:R-CFA-1237044",
"REACTOME:R-CFA-1247673",
"REACTOME:R-CFA-432040",
"REACTOME:R-CFA-432047",
"REACTOME:R-DDI-1237044",
"REACTOME:R-DDI-1247673",
"REACTOME:R-DDI-432040",
"REACTOME:R-D... | 43 | [
"1fqy",
"1fx8",
"1h6i",
"1ih5",
"1j4n",
"1lda",
"1ldf",
"1ldi",
"1rc2",
"1sor",
"1ymg",
"1z98",
"2abm",
"2b5f",
"2b6o",
"2b6p",
"2c32",
"2d57",
"2evu",
"2f2b",
"2o9d",
"2o9e",
"2o9f",
"2o9g",
"2w1p",
"2w2e",
"2zz9",
"3cll",
"3cn5",
"3cn6",
"3d9s",
"3gd8"... | 81 | [
"PUB00005368",
"PUB00025063",
"PUB00028718",
"PUB00053662"
] | [
"1715617",
"11039922",
"11780053",
"10957645"
] | [
"Tandem sequence repeats in transmembrane channel proteins.",
"Structure of a glycerol-conducting channel and the basis for its selectivity.",
"Structural basis of water-specific transport through the AQP1 water channel.",
"Crystallization and preliminary X-ray crystallographic analysis of water channel AQP1.... | [
1991,
2000,
2001,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudovirales sp. ctTqA28",
"Eukaryota",
"metagenomes"
] | [
436,
24739,
1,
35356,
258
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
117,
12,
18,
19,
2,
42,
28,
1,
71,
38,
3,
1,
192
] | 13 | true | Conserved_site | Major intrinsic protein, conserved site | Major intrinsic protein, conserved site | MIP_CS | 3 |
IPR022359 | 22,359 | Aminoglycoside phosphotransferase, bacteria | Aminoglycoside_PTrfase_bact | Domain | 15 | false | false | This entry includes enzymes found in the rumen bacterium Fibrobacter succinogenes subsp succinogenes S85. They are homologous to the aminoglycoside phosphotransferase enzyme family associated with resistance to aminoglycoside antibiotics. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR02172"
] | [
"Fb_sc_TIGR02172"
] | [
15
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR002575"
] | [] | 1 | 0 | 1 | [
"FCB group"
] | [
15
] | 1 | [] | [] | 0 | true | Domain | Aminoglycoside phosphotransferase, bacteria | Aminoglycoside phosphotransferase, bacteria | Aminoglycoside_PTrfase_bact | 4 |
IPR022361 | 22,361 | Tumour necrosis factor receptor 11A | TNFR_11A | Family | 671 | false | false | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [ ]. The cysteines allow formation of ... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01974"
] | [
"TNFACTORR11A"
] | [
671
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5668541",
"R-HSA-5676594",
"R-MMU-5668541",
"R-MMU-5676594"
] | [
"REACTOME:R-HSA-5668541",
"REACTOME:R-HSA-5676594",
"REACTOME:R-MMU-5668541",
"REACTOME:R-MMU-5676594"
] | 4 | [] | 0 | [
"PUB00000892",
"PUB00046030",
"PUB00046031",
"PUB00046032",
"PUB00046033",
"PUB00046034",
"PUB00053612",
"PUB00053613",
"PUB00053663"
] | [
"8387891",
"7917108",
"15500863",
"11239407",
"9826575",
"9826574",
"9878548",
"11485016",
"19416721"
] | [
"Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.",
"Tumor necrosis factor receptor superfamily members and their ligands.",
"Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.",
"The TNF ... | [
1993,
1994,
2004,
2001,
1998,
1998,
1998,
2001,
2009
] | 9 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
671
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2
] | 3 | true | Family | Tumour necrosis factor receptor 11A | Tumour necrosis factor receptor 11A | TNFR_11A | 3 |
IPR022362 | 22,362 | Neurogenic locus notch homolog protein 1 | Notch_1 | Family | 1,814 | false | false | Notch cell surface receptors are large, single-pass type-1 transmembrane proteins found in a diverse range of metazoan species, from human to Caenorhabditis species. The fruit fly, Drosophila melanogaster, possesses only one Notch protein, whereas in C.elegans, two receptors have been found; by contrast, four Notch par... | [
"GO:0038023",
"GO:0006355",
"GO:0007219"
] | [
"signaling receptor activity",
"regulation of DNA-templated transcription",
"Notch signaling pathway"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR01984"
] | [
"NOTCH1"
] | [
1814
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1912399",
"R-HSA-1912408",
"R-HSA-1912420",
"R-HSA-210744",
"R-HSA-2122947",
"R-HSA-2122948",
"R-HSA-2644606",
"R-HSA-2644607",
"R-HSA-2660826",
"R-HSA-2691232",
"R-HSA-2894862",
"R-HSA-350054",
"R-HSA-5083630",
"R-HSA-8941856",
"R-HSA-9013508",
"R-HSA-9013695",
"R-HSA-9793380... | [
"REACTOME:R-HSA-1912399",
"REACTOME:R-HSA-1912408",
"REACTOME:R-HSA-1912420",
"REACTOME:R-HSA-210744",
"REACTOME:R-HSA-2122947",
"REACTOME:R-HSA-2122948",
"REACTOME:R-HSA-2644606",
"REACTOME:R-HSA-2644607",
"REACTOME:R-HSA-2660826",
"REACTOME:R-HSA-2691232",
"REACTOME:R-HSA-2894862",
"REACTOME... | 31 | [] | 0 | [
"PUB00013432",
"PUB00053622",
"PUB00053623",
"PUB00053624",
"PUB00053625",
"PUB00053626",
"PUB00053638",
"PUB00053664"
] | [
"10221902",
"19379690",
"12354787",
"11101851",
"12668592",
"16429119",
"10206645",
"15145534"
] | [
"Notch signaling: cell fate control and signal integration in development.",
"The canonical Notch signaling pathway: unfolding the activation mechanism.",
"The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.",
"MAML1, a human homologue... | [
1999,
2009,
2002,
2000,
2003,
2006,
1999,
2004
] | 8 | [
"IPR008297"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1814
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
6,
1,
2
] | 4 | true | Family | Neurogenic locus notch homolog protein 1 | Neurogenic locus notch homolog protein 1 | Notch_1 | 9 |
IPR022363 | 22,363 | Bacteriophage TP901-1, major tail protein | Phage_TP901-1_major-tail | Family | 42 | false | false | Two major structural proteins from the lactococcal temperate bacteriophage TP901-1 have been sequenced: the Major Head Protein (MHP) and the Major Tail Protein (MTP) [ ]. Homologues of the major tail protein have since been found in Staphylococcus, Streptococcus and Lactobacillus phages. The sequences are fairly short,... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01999"
] | [
"MTP2LACTO"
] | [
42
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015485"
] | [
"8610457"
] | [
"A genomic region of lactococcal temperate bacteriophage TP901-1 encoding major virion proteins."
] | [
1996
] | 1 | [
"IPR022345"
] | [] | 1 | 0 | 1 | [
"Bacillota",
"Caudoviricetes"
] | [
32,
10
] | 2 | [] | [] | 0 | true | Family | Bacteriophage TP901-1, major tail protein | Bacteriophage TP901-1, major tail protein | Phage_TP901-1_major-tail | 9 |
IPR022365 | 22,365 | Clathrin, heavy chain, propeller repeat | Clathrin_H-chain_propeller_rpt | Repeat | 7,678 | false | false | This entry represents the propeller repeat found in clathrin heavy chains. The N terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a β propeller [ ]. Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi appa... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01394"
] | [
"Clathrin_propel"
] | [
7678
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-177504",
"R-BTA-190873",
"R-BTA-196025",
"R-BTA-2132295",
"R-BTA-432720",
"R-BTA-432722",
"R-BTA-437239",
"R-BTA-5099900",
"R-BTA-5140745",
"R-BTA-8856825",
"R-BTA-8856828",
"R-BTA-8866427",
"R-BTA-8964038",
"R-BTA-9013420",
"R-BTA-9013424",
"R-CEL-190873",
"R-CEL-196025",
"... | [
"REACTOME:R-BTA-177504",
"REACTOME:R-BTA-190873",
"REACTOME:R-BTA-196025",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-432720",
"REACTOME:R-BTA-432722",
"REACTOME:R-BTA-437239",
"REACTOME:R-BTA-5099900",
"REACTOME:R-BTA-5140745",
"REACTOME:R-BTA-8856825",
"REACTOME:R-BTA-8856828",
"REACTOME:R-BT... | 114 | [
"1bpo",
"1c9i",
"1c9l",
"1utc",
"1xi4",
"1xi5",
"2xzg",
"3gc3",
"3gd1",
"3iyv",
"4g55",
"5m5r",
"5m5s",
"5m5t",
"5m5u",
"5m5v",
"5m61",
"5ods",
"6e4l",
"6qnn",
"6qnp",
"6sct",
"6wcj",
"6yai",
"7bn1",
"7bn2",
"7om8",
"7zx4",
"9c0y",
"9c0z",
"9ex5",
"9exf"... | 36 | [
"PUB00000964",
"PUB00035753",
"PUB00035765",
"PUB00035769",
"PUB00035906",
"PUB00035907",
"PUB00035908",
"PUB00035909"
] | [
"9827808",
"17449236",
"11598180",
"15261670",
"15752139",
"16806884",
"16734666",
"16699812"
] | [
"Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.",
"Do different endocytic pathways make different synaptic vesicles?",
"Adaptins: the final recount.",
"COP and clathrin-coated vesicle budding: different pathways, common approaches.",
"New faces of the familiar c... | [
1998,
2007,
2001,
2004,
2005,
2006,
2006,
2006
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7678
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
9,
2,
24,
6,
1,
6,
7,
1,
1,
122
] | 12 | true | Repeat | Clathrin, heavy chain, propeller repeat | Clathrin, heavy chain, propeller repeat | Clathrin_H-chain_propeller_rpt | 1 |
IPR022367 | 22,367 | 2-oxoacid:acceptor oxidoreductase, alpha subunit | 2-oxoacid/accept_OxRdtase_asu | Family | 8,697 | false | false | This entry represents the alpha subunit of 2-oxoacid:acceptor oxidoreductases, which catalyse CoA-dependent oxidative decarboxylation of 2-oxoacids. Proteins in this family contain a thiamine diphosphate (TPP) binding domain typical of flavodoxin/ferredoxin oxidoreductases ( ), and an N-terminal domain similar to the g... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03710"
] | [
"OAFO_sf"
] | [
8697
] | 1 | [
"EC",
"GP"
] | [
"1.2.7.11",
"GenProp0842"
] | [
"EC:1.2.7.11",
"GP:GenProp0842"
] | 2 | [
"5b46",
"5b47",
"5b48",
"6n2n",
"6n2o"
] | 5 | [
"PUB00053665",
"PUB00053666",
"PUB00053667",
"PUB00053668",
"PUB00074309",
"PUB00074310",
"PUB00074311"
] | [
"8902625",
"11401501",
"8655524",
"15184674",
"6266826",
"6266827",
"1555599"
] | [
"2-oxoacid:ferredoxin oxidoreductase from the thermoacidophilic archaeon, Sulfolobus sp. strain 7.",
"The genes for anabolic 2-oxoglutarate: ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6.",
"Purification and characterization of 2-oxoglutarate:ferredoxin oxidoreductase from a thermophilic, obl... | [
1996,
2001,
1996,
2004,
1981,
1981,
1992
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1137,
7342,
17,
201
] | 4 | [] | [] | 0 | true | Family | 2-oxoacid:acceptor oxidoreductase, alpha subunit | 2-oxoacid:acceptor oxidoreductase, alpha subunit | 2-oxoacid/accept_OxRdtase_asu | 2 |
IPR022368 | 22,368 | Putative thiazole-containing bacteriocin maturation protein | Thiazole_bacteriocin_mat_put | Family | 547 | false | false | Members of this protein family are found in a three-gene operon in Bacillus anthracis and related Bacillus species, where the other two genes are clearly identified with maturation of a putative thiazole-containing bacteriocin precursor. While there is no detectable pairwise sequence similarity between members of this ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03693"
] | [
"ocin_ThiF_like"
] | [
547
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillales"
] | [
547
] | 1 | [] | [] | 0 | true | Family | Putative thiazole-containing bacteriocin maturation protein | Putative thiazole-containing bacteriocin maturation protein | Thiazole_bacteriocin_mat_put | 9 |
IPR022369 | 22,369 | Integral membrane protein TerC, riboswitch-linked | Integral_membrane_TerC_rswitch | Family | 16,249 | false | false | This entry represents a subset of TerC proteins which are mostly encoded on genes preceded by a structured RNA element known as the yybP-ykoY leader. The yybP-ykoY leader (also known as SraF) may function in the regulation of these genes as riboswitch [ ]. This entry also includes the putative membrane-bound redox modu... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM"
] | [
"TIGR03718"
] | [
"R_switched_Alx"
] | [
16249
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008408",
"PUB00009923",
"PUB00053669",
"PUB00076704",
"PUB00085185"
] | [
"10069007",
"12107143",
"15096624",
"18429937",
"24612058"
] | [
"In vivo and in vitro cloning and phenotype characterization of tellurite resistance determinant conferred by plasmid pTE53 of a clinical isolate of Escherichia coli.",
"pH-dependent expression of periplasmic proteins and amino acid catabolism in Escherichia coli.",
"New RNA motifs suggest an expanded scope for... | [
1998,
2002,
2004,
2008,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
30,
15278,
38,
705,
198
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
1,
2,
7
] | 4 | true | Family | Integral membrane protein TerC, riboswitch-linked | Integral membrane protein TerC, riboswitch-linked | Integral_membrane_TerC_rswitch | 3 |
IPR022370 | 22,370 | Phosphosulpholactate synthase | Arch_ComA | Family | 83 | false | false | This entry represents the ComA (Coenzyme M biosynthesis A) protein and phosphosulpholactate synthase in methanogenic archaea. The ComABC pathway is one of at least two pathways to the intermediate sulphopyruvate. Coenzyme M occurs rarely and sporadically outside of the archaea. | [
"GO:0043817",
"GO:0019295"
] | [
"phosphosulfolactate synthase activity",
"coenzyme M biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR03849"
] | [
"arch_ComA"
] | [
83
] | 1 | [] | [] | [] | 0 | [
"1qwg",
"9cm1"
] | 2 | [] | [] | [] | [] | 0 | [
"IPR003830"
] | [] | 1 | 0 | 1 | [
"Methanomada group",
"bioreactor metagenome"
] | [
82,
1
] | 2 | [] | [] | 0 | true | Family | Phosphosulpholactate synthase | Phosphosulpholactate synthase | Arch_ComA | 4 |
IPR022371 | 22,371 | Exopolyphosphatase | Exopolyphosphatase | Domain | 6,594 | false | false | Exopolyphosphatases (Ppx) is involved in the degradation of inorganic polyphosphates [ ] and belongs to the same family as the guanosine pentaphosphate phosphatase [ ]. | [
"GO:0004309",
"GO:0006793"
] | [
"exopolyphosphatase activity",
"phosphorus metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR03706"
] | [
"exo_poly_only"
] | [
6594
] | 1 | [
"EC",
"GP"
] | [
"3.6.1",
"GenProp0840"
] | [
"EC:3.6.1",
"GP:GenProp0840"
] | 2 | [
"1u6z",
"2flo",
"3hi0",
"8jgw",
"8jgx"
] | 5 | [
"PUB00008176",
"PUB00073652"
] | [
"8212131",
"8380170"
] | [
"Exopolyphosphate phosphatase and guanosine pentaphosphate phosphatase belong to the sugar kinase/actin/hsp 70 superfamily.",
"An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon."
] | [
1993,
1993
] | 2 | [
"IPR003695"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
6549,
4,
41
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Exopolyphosphatase | Exopolyphosphatase | Exopolyphosphatase | 9 |
IPR022372 | 22,372 | Accessory secretory system protein Asp1 | Accessory_SS_Asp1 | Family | 1,037 | false | false | This entry represents Asp1 which, along with SecY2 and SecA2, is part of the accessory secretory protein system [ , ]. This system is involved in the export of serine-rich glycoproteins important for virulence in a number of Gram-positive species, including Streptococcus gordonii and Staphylococcus aureus. This protein... | [
"GO:0015031"
] | [
"protein transport"
] | [
"biological_process"
] | 1 | [
"PFAM",
"NCBIFAM"
] | [
"PF16993",
"TIGR03713"
] | [
"Asp1",
"acc_sec_asp1"
] | [
1037,
767
] | 2 | [] | [] | [] | 0 | [
"5vae",
"5vaf",
"6lnw",
"6oyc"
] | 4 | [
"PUB00053479",
"PUB00098563"
] | [
"18621893",
"32037091"
] | [
"Characterization of the accessory Sec system of Staphylococcus aureus.",
"Structural and functional insights into the Asp1/2/3 complex mediated secretion of pneumococcal serine-rich repeat protein PsrP."
] | [
2008,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
1036,
1
] | 2 | [] | [] | 0 | true | Family | Accessory secretory system protein Asp1 | Accessory secretory system protein Asp1 | Accessory_SS_Asp1 | 5 |
IPR022373 | 22,373 | KaiC domain-containing protein | KaiC_containing | Family | 143 | false | false | This entry represents KaiC domain-containing proteins that occur across a broad taxonomic range (Euryarchaeota, Aquificae, Dictyoglomi, Epsilonproteobacteria, and Firmicutes), but exclusively in thermophiles. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03878"
] | [
"thermo_KaiC_2"
] | [
143
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriati"
] | [
128,
15
] | 2 | [] | [] | 0 | true | Family | KaiC domain-containing protein | KaiC domain-containing protein | KaiC_containing | 1 |
IPR022374 | 22,374 | Energy-dependent translational throttle protein EttA | EttA | Family | 17,261 | false | false | ABC-F proteins compose one of the most widely distributed branches of the ATP-binding cassette (ABC) superfamily. EttA/YjjK is the most prevalent eubacterial ABC-F protein. Its role consists in gating ribosome entry into the translation elongation cycle through a nucleotide-dependent interaction sensitive to ATP/ADP ra... | [
"GO:0045900"
] | [
"negative regulation of translational elongation"
] | [
"biological_process"
] | 1 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_00847",
"PTHR43858",
"TIGR03719"
] | [
"EttA",
"",
"ABC_ABC_ChvD"
] | [
16298,
17261,
16295
] | 3 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.6.1.-",
"PWY-5757",
"PWY-6147",
"PWY-6383",
"PWY-6797",
"PWY-7206",
"PWY-7419",
"PWY-7539",
"PWY-7719",
"PWY-7821",
"PWY-8289"
] | [
"EC:3.6.1.-",
"METACYC:PWY-5757",
"METACYC:PWY-6147",
"METACYC:PWY-6383",
"METACYC:PWY-6797",
"METACYC:PWY-7206",
"METACYC:PWY-7419",
"METACYC:PWY-7539",
"METACYC:PWY-7719",
"METACYC:PWY-7821",
"METACYC:PWY-8289"
] | 11 | [
"3j5s",
"4fin",
"7msc",
"7msh",
"7msm",
"7msz",
"7mu0",
"9nl5",
"9nlb",
"9nle"
] | 10 | [
"PUB00086945",
"PUB00086976"
] | [
"24389466",
"24389465"
] | [
"The ABC-F protein EttA gates ribosome entry into the translation elongation cycle.",
"EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics."
] | [
2014,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
16508,
355,
398
] | 3 | [
"Escherichia coli (strain K12)",
"Zea mays"
] | [
1,
1
] | 2 | true | Family | Energy-dependent translational throttle protein EttA | Energy-dependent translational throttle protein EttA | EttA | 7 |
IPR022377 | 22,377 | Small hydrophilic plant seed protein, conserved site | Sm_Hydphi_plant_seed_CS | Conserved_site | 795 | false | false | This entry represents a conserved site in hydrophilic plant seed proteins that are structurally related: Arabidopsis thaliana proteins GEA1 and GEA6 Cotton late embryogenesis abundant (LEA) protein D-19 Carrot EMB-1 protein Barley LEA proteins B19.1A, B19.1B, B19.3 and B19.4 Maize late embryogenesis abundant protein Em... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00431"
] | [
"SMALL_HYDR_PLANT_SEED"
] | [
795
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003758",
"PUB00015278"
] | [
"8492809",
"12231998"
] | [
"Two different Em-like genes are expressed in Arabidopsis thaliana seeds during maturation.",
"Molecular Responses to Water Deficit."
] | [
1993,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
795
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
1,
5
] | 3 | true | Conserved_site | Small hydrophilic plant seed protein, conserved site | Small hydrophilic plant seed protein, conserved site | Sm_Hydphi_plant_seed_CS | 2 |
IPR022378 | 22,378 | F420-dependent oxidoreductase-predicted, MSMEG2249 | F420_OxRdatse_MSMEG2249_pred | Family | 812 | false | false | Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H and Rhodopseudomonas palustris HaA2. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxy... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03857"
] | [
"F420_MSMEG_2249"
] | [
812
] | 1 | [
"GP"
] | [
"GenProp0002"
] | [
"GP:GenProp0002"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Symbiodinium pilosum",
"freshwater metagenome"
] | [
773,
2,
37
] | 3 | [] | [] | 0 | true | Family | F420-dependent oxidoreductase-predicted, MSMEG2249 | F420-dependent oxidoreductase-predicted, MSMEG2249 | F420_OxRdatse_MSMEG2249_pred | 3 |
IPR022379 | 22,379 | 11-S seed storage protein, conserved site | 11S_seedstore_CS | Conserved_site | 1,632 | false | false | Plant seed storage proteins, whose principal function appears to be the major nitrogen source for the developing plant, can be classified, on the basis of their structure, into different families. 11-S are non-glycosylated proteins which form hexameric structures [ , ]. Each of the subunits in the hexamer is itself com... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00305"
] | [
"11S_SEED_STORAGE"
] | [
1632
] | 1 | [] | [] | [] | 0 | [
"1fxz",
"1od5",
"1ucx",
"1ud1",
"2d5f",
"2d5h",
"2e9q",
"2evx",
"3c3v",
"3ehk",
"3fz3",
"3kgl",
"3ksc",
"3qac",
"5gyl",
"5wxu",
"6b4s",
"8uai",
"9v45",
"9v4f"
] | 20 | [
"PUB00001358",
"PUB00004572"
] | [
"2450746",
"16666210"
] | [
"Nucleotide sequence of cloned cDNA coding for pumpkin 11-S globulin beta subunit.",
"Molecular Characterization of Oat Seed Globulins."
] | [
1988,
1988
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
1630
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica"
] | [
13,
32
] | 2 | true | Conserved_site | 11-S seed storage protein, conserved site | 11-S seed storage protein, conserved site | 11S_seedstore_CS | 3 |
IPR022380 | 22,380 | Glutamyl-Q tRNA(Asp) synthetase | Glu-Q_tRNA(Asp)_Synthase | Family | 8,210 | false | false | This protein resembles a shortened glutamyl-tRNA ligase, but its purpose is to modify tRNA(Asp) at a queuosine position in the anticodon rather than to charge a tRNA with its cognate amino acid [ , ]. It catalyses the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate o... | [
"GO:0000166",
"GO:0004812",
"GO:0008270",
"GO:0006400",
"GO:0006424"
] | [
"nucleotide binding",
"aminoacyl-tRNA ligase activity",
"zinc ion binding",
"tRNA modification",
"glutamyl-tRNA aminoacylation"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 5 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01428",
"TIGR03838"
] | [
"Glu_Q_tRNA_synth",
"queuosine_YadB"
] | [
7728,
8009
] | 2 | [
"EC"
] | [
"6.1.1.-"
] | [
"EC:6.1.1.-"
] | 1 | [
"1nzj",
"4a91"
] | 2 | [
"PUB00050376",
"PUB00053672",
"PUB00053673",
"PUB00100052",
"PUB00100054"
] | [
"18602926",
"16164993",
"15096612",
"15096594",
"24505021"
] | [
"Crystal structure of glutamyl-queuosine tRNAAsp synthetase complexed with L-glutamate: structural elements mediating tRNA-independent activation of glutamate and glutamylation of tRNAAsp anticodon.",
"Glu-Q-tRNA(Asp) synthetase coded by the yadB gene, a new paralog of aminoacyl-tRNA synthetase that glutamylates ... | [
2008,
2005,
2004,
2004,
2014
] | 5 | [
"IPR049940"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8110,
6,
94
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Glutamyl-Q tRNA(Asp) synthetase | Glutamyl-Q tRNA(Asp) synthetase | Glu-Q_tRNA(Asp)_Synthase | 3 |
IPR022381 | 22,381 | Uncharacterised protein family MG067 | Uncharacterised_MG067 | Family | 524 | false | false | Mycoplasma genitalium has the smallest known genome of any free-living organism. Its complete genome sequence has been determined by whole genome random sequencing and assembly. Only 470 putative coding regions were identified, including genes for DNA replication, transcription and translation, DNA repair, cellular tra... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR00840"
] | [
"Y06768FAMILY"
] | [
524
] | 1 | [] | [] | [] | 0 | [
"7adk"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mycoplasmatota"
] | [
524
] | 1 | [] | [] | 0 | true | Family | Uncharacterised protein family MG067 | Uncharacterised protein family MG067 | Uncharacterised_MG067 | 8 |
IPR022382 | 22,382 | Mycoplasma immunoglobulin protease | MIP_domain | Domain | 866 | false | false | This is the serine protease domain of MIP (Mycoplasma immunoglobulin protease), a protein that is related to pathogenicity of animal and human pathogenic Mycoplasmas [ , , ]. This protein functions together with the Ig binding protein M (MIB) to evade host Ig-mediated defense against the MIB-MIP system, which is a nove... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01732"
] | [
"Mycop_pep_DUF31"
] | [
866
] | 1 | [] | [] | [] | 0 | [
"7adk"
] | 1 | [
"PUB00098027",
"PUB00098028",
"PUB00098029",
"PUB00151017"
] | [
"32373096",
"31497004",
"31540994",
"33674316"
] | [
"Characterization of an Immunoglobulin Binding Protein (IbpM) From Mycoplasma pneumoniae.",
"Subversion of the Immune Response by Human Pathogenic Mycoplasmas.",
"Proteases as Secreted Exoproteins in Mycoplasmas from Ruminant Lungs and Their Impact on Surface-Exposed Proteins.",
"The mycoplasma surface protei... | [
2020,
2019,
2019,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
866
] | 1 | [] | [] | 0 | true | Domain | Mycoplasma immunoglobulin protease | Mycoplasma immunoglobulin protease | MIP_domain | 2 |
IPR022383 | 22,383 | Lactate/malate dehydrogenase, C-terminal | Lactate/malate_DH_C | Domain | 63,311 | false | false | This entry represents the C-terminal, and is thought to be an is an unusual α+β fold. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis [ ]. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. L... | [
"GO:0016616"
] | [
"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02866"
] | [
"Ldh_1_C"
] | [
63311
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"1.1.1",
"1.1.1.37",
"PWY-1622",
"PWY-5392",
"PWY-561",
"PWY-5690",
"PWY-6728",
"PWY-6969",
"PWY-7115",
"PWY-7383",
"PWY-8086",
"R-BTA-70268",
"R-BTA-71403",
"R-BTA-9837999",
"R-BTA-9856872",
"R-BTA-9861718",
"R-CEL-70268",
"R-CEL-71403",
"R-CEL-9837999",
"R-CEL-9856872",
"R-... | [
"EC:1.1.1",
"EC:1.1.1.37",
"METACYC:PWY-1622",
"METACYC:PWY-5392",
"METACYC:PWY-561",
"METACYC:PWY-5690",
"METACYC:PWY-6728",
"METACYC:PWY-6969",
"METACYC:PWY-7115",
"METACYC:PWY-7383",
"METACYC:PWY-8086",
"REACTOME:R-BTA-70268",
"REACTOME:R-BTA-71403",
"REACTOME:R-BTA-9837999",
"REACTOM... | 53 | [
"1a5z",
"1b8p",
"1b8u",
"1b8v",
"1bdm",
"1bmd",
"1ceq",
"1cet",
"1civ",
"1d3a",
"1emd",
"1ez4",
"1guy",
"1guz",
"1gv0",
"1gv1",
"1hlp",
"1hye",
"1hyg",
"1hyh",
"1i0z",
"1i10",
"1ib6",
"1ie3",
"1iz9",
"1ldb",
"1ldg",
"1ldm",
"1ldn",
"1llc",
"1lld",
"1lth"... | 328 | [
"PUB00025866",
"PUB00027386"
] | [
"11276087",
"8117664"
] | [
"Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.",
"Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases."
] | [
2001,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
863,
32514,
29357,
2,
575
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
51,
4,
35,
13,
2,
42,
26,
3,
33,
35,
3,
2,
71
] | 13 | true | Domain | Lactate/malate dehydrogenase, C-terminal | Lactate/malate dehydrogenase, C-terminal | Lactate/malate_DH_C | 7 |
IPR022384 | 22,384 | Formiminotransferase catalytic domain superfamily | FormiminoTrfase_cat_dom_sf | Homologous_superfamily | 5,242 | false | false | This entry represents the formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD), which forms a homodimer, with each protomer being comprised of two subdomains. Each subdomain has the structure consisting of an α/β sandwich with antiparallel β-sheet in the form (β-α-β)x2. Tetrahydrofolate (THF)-... | [
"GO:0005542",
"GO:0016740"
] | [
"folic acid binding",
"transferase activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"SSF"
] | [
"SSF55116"
] | [
""
] | [
5242
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.2.5",
"PWY-5030",
"R-DDI-70921",
"R-HSA-70921",
"R-MMU-70921",
"R-RNO-70921"
] | [
"EC:2.1.2.5",
"METACYC:PWY-5030",
"REACTOME:R-DDI-70921",
"REACTOME:R-HSA-70921",
"REACTOME:R-MMU-70921",
"REACTOME:R-RNO-70921"
] | 6 | [
"1qd1",
"1tt9",
"2pfd"
] | 3 | [
"PUB00007432",
"PUB00015609"
] | [
"10673422",
"12815595"
] | [
"The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme.",
"The molecular basis of glutamate formiminotransferase deficiency."
] | [
2000,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
38,
1763,
3260,
181
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
22,
7,
1,
10,
2,
40
] | 7 | true | Homologous_superfamily | Formiminotransferase catalytic domain superfamily | Formiminotransferase catalytic domain superfamily | FormiminoTrfase_cat_dom_sf | 9 |
IPR022385 | 22,385 | Rhs repeat-associated core | Rhs_assc_core | Domain | 51,763 | false | false | This entry represents a conserved unique core sequence shared by large numbers of proteins. It is occasionally found in the Archaea, including Methanosarcina barkeri) but commonly found in the bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03696"
] | [
"Rhs_assc_core"
] | [
51763
] | 1 | [] | [] | [] | 0 | [
"4igl",
"4o9x",
"5kis",
"6cmx",
"6fay",
"6fb3",
"6h6e",
"6h6f",
"6h6g",
"6l7i",
"6ska",
"6ske",
"6sue",
"6suf",
"6sup",
"6suq",
"6u08",
"7bam",
"7ban",
"7bao",
"7pq5",
"7q97",
"8cp6",
"8fjp",
"8h8a",
"8h8b",
"8h8c",
"8qja",
"8qjb",
"8qjc",
"8qjd",
"8r50"... | 36 | [
"PUB00070343",
"PUB00070351"
] | [
"23913273",
"22841666"
] | [
"The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device.",
"Teneurin protein family: an emerging role in human tumorigenesis and drug resistance."
] | [
2013,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
70,
43978,
6,
7402,
307
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
138,
1,
8,
12,
10,
29
] | 6 | true | Domain | Rhs repeat-associated core | Rhs repeat-associated core | Rhs_assc_core | 4 |
IPR022386 | 22,386 | Carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein | Chitin_NgcE | Family | 1,987 | false | false | Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-bi... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03851"
] | [
"chitin_NgcE"
] | [
1987
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00071925",
"PUB00071938",
"PUB00085824"
] | [
"18310026",
"8003968",
"16428842"
] | [
"Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acidic amino acid uptake: biochemical properties and regulation by the Aau two-component system.",
"Sequence relationships between integral inner membrane proteins of binding protein-dependent transport systems: evolution by recurren... | [
2008,
1994,
2006
] | 3 | [
"IPR006059"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
1987
] | 1 | [] | [] | 0 | true | Family | Carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein | Carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein | Chitin_NgcE | 5 |
IPR022387 | 22,387 | Carbohydrate ABC transporter substrate-binding, CPR0540 | Bind_CPR0540 | Family | 512 | false | false | Members of this protein are the substrate-binding protein of a predicted carbohydrate transporter operon, together with permease subunits of ABC transporter homology families. This substrate-binding protein frequently co-occurs in genomes with a family of disaccharide phosphorylases, , suggesting that the molecule tran... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03850"
] | [
"bind_CPR_0540"
] | [
512
] | 1 | [] | [] | [] | 0 | [
"9h0n",
"9h0o",
"9h0p"
] | 3 | [
"PUB00071925",
"PUB00071938"
] | [
"18310026",
"8003968"
] | [
"Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acidic amino acid uptake: biochemical properties and regulation by the Aau two-component system.",
"Sequence relationships between integral inner membrane proteins of binding protein-dependent transport systems: evolution by recurren... | [
2008,
1994
] | 2 | [
"IPR006059"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"metagenomes"
] | [
510,
2
] | 2 | [] | [] | 0 | true | Family | Carbohydrate ABC transporter substrate-binding, CPR0540 | Carbohydrate ABC transporter substrate-binding, CPR0540 | Bind_CPR0540 | 9 |
IPR022389 | 22,389 | ParB-related, ThiF-related cassette, protein D | PRTRC_protein-D | Family | 224 | false | false | A novel genetic system, often found on plasmids, encodes six major proteins, included a ParB homologue and a ThiF homologue, and is designated PRTRC (ParB-Related, ThiF-Related Cassette). This entry represents PRTRC system protein D. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03739"
] | [
"PRTRC_D"
] | [
224
] | 1 | [
"GP"
] | [
"GenProp0854"
] | [
"GP:GenProp0854"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gibberella intermedia",
"Pseudomonadota",
"ecological metagenomes"
] | [
2,
219,
3
] | 3 | [] | [] | 0 | true | Family | ParB-related, ThiF-related cassette, protein D | ParB-related, ThiF-related cassette, protein D | PRTRC_protein-D | 1 |
IPR022390 | 22,390 | 4-hydroxybenzoate decarboxylase subunit C | HBDC | Family | 2,590 | false | false | This entry represents a group of bacterial archaeal decarboxylases, including the 4-hydroxybenzoate decarboxylase subunit C (also known as HBDC) from Chlamydophila pneumoniae AR39. HBDC catalyses the reversible decarboxylation of 4-hydroxybenzoate [ ]. | [
"GO:0016831"
] | [
"carboxy-lyase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR03701"
] | [
"mena_SCO4490"
] | [
2590
] | 1 | [
"GP"
] | [
"GenProp0829"
] | [
"GP:GenProp0829"
] | 1 | [] | 0 | [
"PUB00077014"
] | [
"17211544"
] | [
"Purification and characterization of a 4-hydroxybenzoate decarboxylase from Chlamydophila pneumoniae AR39."
] | [
2007
] | 1 | [
"IPR002830"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Geodia barretti",
"unclassified sequences"
] | [
104,
2418,
15,
53
] | 4 | [] | [] | 0 | true | Family | 4-hydroxybenzoate decarboxylase subunit C | 4-hydroxybenzoate decarboxylase subunit C | HBDC | 1 |
IPR022391 | 22,391 | Integrating conjugative element relaxase, PFGI-1 class | ICE_relaxase_PFGI-1 | Domain | 2,010 | false | false | Proteins in this entry are the TraI putative relaxases required for transfer by a subclass of integrating conjugative elements (ICE) as found in Pseudomonas fluorescens Pf-5, and understood from study of two related ICE, SXT and R391. There is no homology detected to the similarly named TraI relaxase of the F plasmid. ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03760"
] | [
"ICE_TraI_Pfluor"
] | [
2010
] | 1 | [
"GP"
] | [
"GenProp0855"
] | [
"GP:GenProp0855"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR011119"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1986,
5,
19
] | 3 | [] | [] | 0 | true | Domain | Integrating conjugative element relaxase, PFGI-1 class | Integrating conjugative element relaxase, PFGI-1 class | ICE_relaxase_PFGI-1 | 6 |
IPR022392 | 22,392 | Anchored repeat-type ABC transporter, permease subunit | Anch_rpt-typ_ABC_trnsprt_perm | Family | 481 | false | false | This entry represents the permease subunit of a binding protein-dependent ABC transporter complex. The gene encoding this subunit is strictly associated with an adjacent gene encoding a sunbstrate binding protein containing the domain. Homologous permease subunits outside the scope of this family include manganese tran... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03770"
] | [
"anch_rpt_perm"
] | [
481
] | 1 | [
"GP"
] | [
"GenProp0857"
] | [
"GP:GenProp0857"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR001626"
] | [] | 1 | 0 | 1 | [
"Actinomycetota"
] | [
481
] | 1 | [] | [] | 0 | true | Family | Anchored repeat-type ABC transporter, permease subunit | Anchored repeat-type ABC transporter, permease subunit | Anch_rpt-typ_ABC_trnsprt_perm | 4 |
IPR022393 | 22,393 | Conjugative transposon, TraJ | Conjugative_transposon_TraJ | Family | 2,256 | false | false | Proteins in this entry are designated TraJ and are found in a proposed transfer region of a class of conjugative transposon found primarily in the Bacteroides lineage. They are related to conjugation system proteins in the Proteobacteria, including TrbL of Agrobacterium Ti plasmids and VirB6. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03782"
] | [
"Bac_Flav_CT_J"
] | [
2256
] | 1 | [
"GP"
] | [
"GenProp0858"
] | [
"GP:GenProp0858"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
2229,
27
] | 2 | [] | [] | 0 | true | Family | Conjugative transposon, TraJ | Conjugative transposon, TraJ | Conjugative_transposon_TraJ | 1 |
IPR022394 | 22,394 | Methylamine utilisation protein, MauG | Methylamine_utilis_MauG | Family | 25 | false | false | This entry represents methylamine utilisation protein, MauG, as found in Methylobacterium extorquens and related species. This protein is involved in methylamine metabolism and is required to complete the maturation of the tryptophan tryptophylquinone (TTQ) cofactor in the methylamine dehydrogenase light (beta) chain [... | [
"GO:0005509",
"GO:0016491",
"GO:0020037",
"GO:0030416"
] | [
"calcium ion binding",
"oxidoreductase activity",
"heme binding",
"methylamine metabolic process"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 4 | [
"NCBIFAM"
] | [
"TIGR03791"
] | [
"TTQ_mauG"
] | [
25
] | 1 | [
"GP"
] | [
"GenProp0860"
] | [
"GP:GenProp0860"
] | 1 | [] | 0 | [
"PUB00060310",
"PUB00060317"
] | [
"21128656",
"19196017"
] | [
"The Tightly Bound Calcium of MauG Is Required for Tryptophan Tryptophylquinone Cofactor Biosynthesis.",
"Kinetic mechanism for the initial steps in MauG-dependent tryptophan tryptophylquinone biosynthesis."
] | [
2010,
2009
] | 2 | [
"IPR026259"
] | [] | 1 | 0 | 1 | [
"Pseudomonadota"
] | [
25
] | 1 | [] | [] | 0 | true | Family | Methylamine utilisation protein, MauG | Methylamine utilisation protein, MauG | Methylamine_utilis_MauG | 4 |
IPR022395 | 22,395 | Conserved hypothetical protein CHP03773, ABC transporter-like | CHP03773_ABC_transptr-like | Family | 365 | false | false | Members of this protein family occur in genomes that contain a three-gene ABC transporter operon associated with the presence of domain . That domain occurs as a single-copy insert in the substrate-binding protein, and occurs in two or more copies in members of this protein family. Members of this family typically are ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03773"
] | [
"anch_rpt_wall"
] | [
365
] | 1 | [
"GP"
] | [
"GenProp0857"
] | [
"GP:GenProp0857"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetota"
] | [
365
] | 1 | [] | [] | 0 | true | Family | Conserved hypothetical protein CHP03773, ABC transporter-like | Conserved hypothetical protein CHP03773, ABC transporter-like | CHP03773_ABC_transptr-like | 9 |
IPR022396 | 22,396 | ParB-related, ThiF-related cassette, ParB | PRTRC_ParB | Family | 333 | false | false | A novel genetic system characterised by six major proteins, included a ParB homologue and a ThiF homologue, is designated PRTRC, or ParB-Related,ThiF-Related Cassette. It is often found on plasmids. In this entry the members are related to ParB. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03734"
] | [
"PRTRC_parB"
] | [
333
] | 1 | [
"GP"
] | [
"GenProp0854"
] | [
"GP:GenProp0854"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"Ricinus communis",
"ecological metagenomes"
] | [
328,
1,
4
] | 3 | [] | [] | 0 | true | Family | ParB-related, ThiF-related cassette, ParB | ParB-related, ThiF-related cassette, ParB | PRTRC_ParB | 1 |
IPR022397 | 22,397 | Tyrosine decarboxylase, bacteria | Tyrosine_deCO2ase_bac | Family | 270 | false | false | Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [ , , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of a... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03811"
] | [
"tyr_de_CO2_Ent"
] | [
270
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"4.1.1.-",
"4.1.1.25",
"PWY-3385",
"PWY-3542",
"PWY-3581",
"PWY-5113",
"PWY-5163",
"PWY-5254",
"PWY-5474",
"PWY-5706",
"PWY-5826",
"PWY-5870",
"PWY-5871",
"PWY-5872",
"PWY-5873",
"PWY-5956",
"PWY-6055",
"PWY-6133",
"PWY-6262",
"PWY-6309",
"PWY-6322",
"PWY-6340",
"PWY-6627... | [
"EC:4.1.1.-",
"EC:4.1.1.25",
"METACYC:PWY-3385",
"METACYC:PWY-3542",
"METACYC:PWY-3581",
"METACYC:PWY-5113",
"METACYC:PWY-5163",
"METACYC:PWY-5254",
"METACYC:PWY-5474",
"METACYC:PWY-5706",
"METACYC:PWY-5826",
"METACYC:PWY-5870",
"METACYC:PWY-5871",
"METACYC:PWY-5872",
"METACYC:PWY-5873",... | 51 | [
"5hsi",
"5hsj",
"7cwx",
"7cwy",
"7cwz",
"7cx0",
"7cx1"
] | 7 | [
"PUB00001452",
"PUB00002358",
"PUB00003414",
"PUB00004715",
"PUB00006322",
"PUB00035504",
"PUB00035505",
"PUB00035506",
"PUB00035507",
"PUB00035508",
"PUB00053677",
"PUB00076906",
"PUB00094543"
] | [
"8181483",
"8889823",
"2124279",
"2300558",
"7748903",
"15581583",
"8690703",
"15189147",
"17109392",
"16763894",
"12089039",
"24415726",
"16766535"
] | [
"Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases.",
"Functionally important residues of aromatic L-amino acid decarboxylase probed by sequence alignment and site-directed mutagenesis.",
"Prokaryotic and eukaryotic pyridoxal-dependent decarboxylases are homologous.",
... | [
1994,
1996,
1990,
1990,
1995,
2005,
1995,
2004,
2006,
2006,
2002,
2014,
2006
] | 13 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
270
] | 1 | [] | [] | 0 | true | Family | Tyrosine decarboxylase, bacteria | Tyrosine decarboxylase, bacteria | Tyrosine_deCO2ase_bac | 8 |
IPR022398 | 22,398 | Peptidase S8, subtilisin, His-active site | Peptidase_S8_His-AS | Active_site | 89,474 | false | false | This entry represents the conserved sequence around the His active site of Subtilisin-like proteases. Subtilases [ ] are an extensive family of serine proteases belonging to the MEROPS peptidase family S8 (subtilisin, clan SB). Members of this family have a catalytic triad in the order Asp, His and Ser in the sequence,... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00137"
] | [
"SUBTILASE_HIS"
] | [
89474
] | 1 | [
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"3.4.21",
"3.4.21.-",
"PWY-7884",
"R-CEL-1592389",
"R-CEL-186797",
"R-CEL-2173789",
"R-CEL-2173796",
"R-CEL-983168",
"R-DDI-1369007",
"R-DDI-159418",
"R-DDI-193368",
"R-DDI-382556",
"R-DDI-9754706",
"R-DDI-9757110",
"R-DME-1592389",
"R-DME-186797",
"R-DME-2173789",
"R-DME-2173796",... | [
"EC:3.4.21",
"EC:3.4.21.-",
"METACYC:PWY-7884",
"REACTOME:R-CEL-1592389",
"REACTOME:R-CEL-186797",
"REACTOME:R-CEL-2173789",
"REACTOME:R-CEL-2173796",
"REACTOME:R-CEL-983168",
"REACTOME:R-DDI-1369007",
"REACTOME:R-DDI-159418",
"REACTOME:R-DDI-193368",
"REACTOME:R-DDI-382556",
"REACTOME:R-DDI... | 102 | [
"1a2q",
"1af4",
"1ah2",
"1ak9",
"1aqn",
"1au9",
"1av7",
"1avt",
"1be6",
"1be8",
"1bfk",
"1bfu",
"1bh6",
"1bjr",
"1c3l",
"1c9j",
"1c9m",
"1c9n",
"1cnm",
"1cse",
"1dbi",
"1dui",
"1ea7",
"1egq",
"1gci",
"1gns",
"1gnv",
"1ht3",
"1iav",
"1ic6",
"1jea",
"1lw6"... | 509 | [
"PUB00004957"
] | [
"1798697"
] | [
"Homology modelling and protein engineering strategy of subtilases, the family of subtilisin-like serine proteinases."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1383,
47310,
40241,
39,
501
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
57,
5,
27,
13,
31,
32,
4,
20,
34,
4,
4,
10
] | 12 | true | Active_site | Peptidase S8, subtilisin, His-active site | Peptidase S8, subtilisin, His-active site | Peptidase_S8_His-AS | 4 |
IPR022399 | 22,399 | TadA-like conjugal transfer-associated ATPase | TadA-like_ATPase | Family | 3,943 | false | false | This protein family represent a group of putative conjugal transfer-associated TadA-like ATPases associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer [ , ]. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03819"
] | [
"heli_sec_ATPase"
] | [
3943
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00067502",
"PUB00106782"
] | [
"11029439",
"18554329"
] | [
"Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea.",
"The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis."
] | [
2000,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viridiplantae",
"metagenomes"
] | [
3919,
2,
22
] | 3 | [] | [] | 0 | true | Family | TadA-like conjugal transfer-associated ATPase | TadA-like conjugal transfer-associated ATPase | TadA-like_ATPase | 2 |
IPR022400 | 22,400 | Adhesin P1 | Adhesin_P1 | Family | 101 | false | false | Members of this protein family are the major adhesin of the Mycoplasma terminal organelle. The protein is called adhesin P1 and is found in Mycoplasma genitalium, Mycoplasma pneumoniae and Mycoplasma gallisepticum. A conserved C-terminal region is shared by additional paralogs in M. pneumoniae and M. gallisepticum. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03839"
] | [
"termin_org_P1"
] | [
101
] | 1 | [] | [] | [] | 0 | [
"6rc9",
"6rut",
"6s3u",
"6yrk",
"7bwm",
"8pbx",
"8pby",
"8pbz",
"8pc0",
"8pc1",
"8ror"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mycoplasmoides"
] | [
101
] | 1 | [] | [] | 0 | true | Family | Adhesin P1 | Adhesin P1 | Adhesin_P1 | 9 |
IPR022401 | 22,401 | Cysteate synthase | Cysteate_synthase | Family | 301 | false | false | This entry represents cysteate synthase, an enzyme of alternate pathway to sulphopyruvate, a precursor of coenzyme M [ ]. | [
"GO:0016765"
] | [
"transferase activity, transferring alkyl or aryl (other than methyl) groups"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_02109",
"TIGR03844"
] | [
"Cya_synthase",
"cysteate_syn"
] | [
71,
301
] | 2 | [
"EC",
"GP",
"METACYC"
] | [
"2.5.1.76",
"GenProp0893",
"PWY-6643"
] | [
"EC:2.5.1.76",
"GP:GenProp0893",
"METACYC:PWY-6643"
] | 3 | [
"9k3c",
"9k3o"
] | 2 | [
"PUB00053897"
] | [
"19761441"
] | [
"Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriati",
"ecological metagenomes"
] | [
162,
124,
15
] | 3 | [] | [] | 0 | true | Family | Cysteate synthase | Cysteate synthase | Cysteate_synthase | 3 |
IPR022402 | 22,402 | F420-dependent oxidoreductase-predicted, MSMEG3544 | F420_OxRdatse_MSMEG3544_pred | Family | 406 | false | false | Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H and Rhodopseudomonas palustris HaA2. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxy... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03854"
] | [
"F420_MSMEG_3544"
] | [
406
] | 1 | [
"GP"
] | [
"GenProp0002"
] | [
"GP:GenProp0002"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"freshwater metagenome"
] | [
404,
2
] | 2 | [] | [] | 0 | true | Family | F420-dependent oxidoreductase-predicted, MSMEG3544 | F420-dependent oxidoreductase-predicted, MSMEG3544 | F420_OxRdatse_MSMEG3544_pred | 9 |
IPR022404 | 22,404 | Diphtheria toxin, receptor-binding domain | Diphtheria_toxin_rcpt-bd_dom | Domain | 28 | false | false | This entry represents the C-terminal receptor-binding domain, also known as the R domain. This domain has a β-sandwich fold consisting of nine strands in two sheet with greek-key topology; it is a subclass of immunoglobin-like fold [ ]. The R domain binds to cell surface receptor, permitting the toxin to enter the cell... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01324"
] | [
"Diphtheria_R"
] | [
28
] | 1 | [
"REACTOME"
] | [
"R-HSA-5336415"
] | [
"REACTOME:R-HSA-5336415"
] | 1 | [
"1ddt",
"1f0l",
"1mdt",
"1sgk",
"1tox",
"1xdt",
"4ae0",
"4ae1",
"4ow6",
"5i82",
"7k7b",
"7k7c",
"7k7d",
"7k7e",
"7o4w",
"7rrw",
"8g0f",
"8g0g",
"9biw"
] | 19 | [
"PUB00000429",
"PUB00004122",
"PUB00005016",
"PUB00037609"
] | [
"8573568",
"1589020",
"7833808",
"9012663"
] | [
"Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide.",
"The crystal structure of diphtheria toxin.",
"Refined structure of monomeric diphtheria toxin at 2.3 A resolution.",
"Crystal structure of nucleotide-free diphtheria toxin."
] | [
1996,
1992,
1994,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"unclassified Lambdavirus"
] | [
23,
5
] | 2 | [] | [] | 0 | true | Domain | Diphtheria toxin, receptor-binding domain | Diphtheria toxin, receptor-binding domain | Diphtheria_toxin_rcpt-bd_dom | 7 |
IPR022406 | 22,406 | Diphtheria toxin, catalytic domain | Diphtheria_toxin_catalytic_dom | Domain | 42 | false | false | This entry represents the N-terminal catalytic domain (also known as the C domain). This domain has an unusual β+α fold [ ]. The C domain blocks protein synthesis by transfer of ADP-ribose from NAD to a diphthamide residue of EF-2 [ , ]. Diphtheria toxin ( ) is a 58kDa protein secreted by lysogenic strains of Corynebac... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02763"
] | [
"Diphtheria_C"
] | [
42
] | 1 | [
"REACTOME"
] | [
"R-HSA-5336415"
] | [
"REACTOME:R-HSA-5336415"
] | 1 | [
"1ddt",
"1dtp",
"1f0l",
"1mdt",
"1sgk",
"1tox",
"1xdt",
"4ae0",
"4ae1",
"4ow6",
"5i82",
"7k7b",
"7k7c",
"7k7d",
"7k7e",
"7o4w",
"7rb4",
"7rrw",
"8g0f",
"8g0g",
"9biw"
] | 21 | [
"PUB00000429",
"PUB00004122",
"PUB00005016",
"PUB00037609"
] | [
"8573568",
"1589020",
"7833808",
"9012663"
] | [
"Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide.",
"The crystal structure of diphtheria toxin.",
"Refined structure of monomeric diphtheria toxin at 2.3 A resolution.",
"Crystal structure of nucleotide-free diphtheria toxin."
] | [
1996,
1992,
1994,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Bacillati",
"unclassified Lambdavirus"
] | [
37,
5
] | 2 | [] | [] | 0 | true | Domain | Diphtheria toxin, catalytic domain | Diphtheria toxin, catalytic domain | Diphtheria_toxin_catalytic_dom | 5 |
IPR022407 | 22,407 | Oxidoreductase, molybdopterin binding site | OxRdtase_Mopterin_BS | Binding_site | 6,582 | false | false | This entry represents a motif surrounding a cysteine residue that could be involved in binding the molybdopterin cofactor. A number of different eukaryotic oxidoreductases that require and bind a molybdopterin cofactor have been shown [ ] to share a few regions of sequence similarity. These enzymes include xanthine deh... | [
"GO:0043546"
] | [
"molybdopterin cofactor binding"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00559"
] | [
"MOLYBDOPTERIN_EUK"
] | [
6582
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-74259",
"R-DME-964975",
"R-DME-9748787",
"R-GGA-421178",
"R-HSA-1614517",
"R-HSA-74259",
"R-HSA-8851680",
"R-HSA-964975",
"R-HSA-9748787",
"R-MMU-1614517",
"R-MMU-74259",
"R-MMU-8851680",
"R-MMU-964975",
"R-MMU-9748787",
"R-RNO-1614517",
"R-RNO-74259",
"R-RNO-8851680",
"R-RN... | [
"REACTOME:R-DME-74259",
"REACTOME:R-DME-964975",
"REACTOME:R-DME-9748787",
"REACTOME:R-GGA-421178",
"REACTOME:R-HSA-1614517",
"REACTOME:R-HSA-74259",
"REACTOME:R-HSA-8851680",
"REACTOME:R-HSA-964975",
"REACTOME:R-HSA-9748787",
"REACTOME:R-MMU-1614517",
"REACTOME:R-MMU-74259",
"REACTOME:R-MMU-8... | 19 | [
"1fiq",
"1fo4",
"1n5x",
"1v97",
"1vdv",
"1wyg",
"2a9d",
"2bih",
"2bii",
"2ckj",
"2e1q",
"2e3t",
"3am9",
"3amz",
"3an1",
"3ax7",
"3ax9",
"3b9j",
"3bdj",
"3etr",
"3eub",
"3nrz",
"3ns1",
"3nvv",
"3nvw",
"3nvy",
"3nvz",
"3sr6",
"3una",
"3unc",
"3uni",
"4uhw"... | 50 | [
"PUB00000608",
"PUB00005356",
"PUB00007725"
] | [
"2015248",
"2204158",
"9428520"
] | [
"Enzymes depending on the pterin molybdenum cofactor: sequence families, spectroscopic properties of molybdenum and possible cofactor-binding domains.",
"Functional domains of assimilatory nitrate reductases and nitrite reductases.",
"Molecular basis of sulfite oxidase deficiency from the structure of sulfite o... | [
1991,
1990,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
177,
6396,
9
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
1,
1,
8,
8,
1,
8,
12,
18
] | 9 | true | Binding_site | Oxidoreductase, molybdopterin binding site | Oxidoreductase, molybdopterin binding site | OxRdtase_Mopterin_BS | 6 |
IPR022408 | 22,408 | Acyl-CoA-binding protein, ACBP, conserved site | Acyl-CoA-binding_prot_CS | Conserved_site | 8,506 | false | false | This entry represents a motif that corresponds to residue 19 to 37 in mammalian ACBP, adn which contains a conserved site. Acyl-CoA-binding protein (ACBP) is a small (10 Kd) protein that binds medium-and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters [... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00880"
] | [
"ACB_1"
] | [
8506
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-390918",
"R-BTA-77289",
"R-CEL-390918",
"R-CFA-77289",
"R-DDI-77289",
"R-DRE-390918",
"R-DRE-8980692",
"R-DRE-9603798",
"R-HSA-390247",
"R-HSA-390918",
"R-HSA-432722",
"R-HSA-77289",
"R-HSA-8980692",
"R-HSA-9013106",
"R-HSA-9033241",
"R-HSA-9603798",
"R-MMU-390247",
"R-MMU-3... | [
"REACTOME:R-BTA-390918",
"REACTOME:R-BTA-77289",
"REACTOME:R-CEL-390918",
"REACTOME:R-CFA-77289",
"REACTOME:R-DDI-77289",
"REACTOME:R-DRE-390918",
"REACTOME:R-DRE-8980692",
"REACTOME:R-DRE-9603798",
"REACTOME:R-HSA-390247",
"REACTOME:R-HSA-390918",
"REACTOME:R-HSA-432722",
"REACTOME:R-HSA-7728... | 36 | [
"1aca",
"1hb6",
"1hb8",
"1nti",
"1nvl",
"1st7",
"2abd",
"2cb8",
"2cqu",
"2fdq",
"2fj9",
"2wh5",
"3flv",
"5h3g"
] | 14 | [
"PUB00000679",
"PUB00003552",
"PUB00003711",
"PUB00004768",
"PUB00021736",
"PUB00035335"
] | [
"10354522",
"1649940",
"8898349",
"1454809",
"11491287",
"16018771"
] | [
"Molecular cloning and expression of a novel human cDNA related to the diazepam binding inhibitor.",
"Diazepam binding inhibitor (DBI): a peptide with multiple biological actions.",
"A novel endozepine-like peptide (ELP) is exclusively expressed in male germ cells.",
"Molecular cloning of the gene for the yea... | [
1999,
1991,
1996,
1992,
2001,
2005
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Klosneuvirinae",
"environmental samples",
"metagenomes"
] | [
519,
7971,
3,
3,
10
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
3,
30,
6,
43,
30,
2,
30,
1,
6
] | 9 | true | Conserved_site | Acyl-CoA-binding protein, ACBP, conserved site | Acyl-CoA-binding protein, ACBP, conserved site | Acyl-CoA-binding_prot_CS | 9 |
IPR022409 | 22,409 | PKD/Chitinase domain | PKD/Chitinase_dom | Domain | 42,792 | false | false | The PKD (Polycystic Kidney Disease) domain was first identified in the Polycystic Kidney Disease protein, polycystin-1 (PDK1 gene), and contains an Ig-like fold consisting of a β-sandwich of seven strands in two sheets with a Greek key topology, although some members have additional strands [ ]. Polycystin-1 is a large... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00089"
] | [
"PKD"
] | [
42792
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620916",
"R-HSA-8856825",
"R-HSA-8856828",
"R-HSA-8857538",
"R-HSA-9824585",
"R-MMU-5620916",
"R-MMU-8856825",
"R-MMU-8856828",
"R-MMU-8857538",
"R-RNO-8856825",
"R-RNO-8856828",
"R-RNO-8857538"
] | [
"REACTOME:R-HSA-5620916",
"REACTOME:R-HSA-8856825",
"REACTOME:R-HSA-8856828",
"REACTOME:R-HSA-8857538",
"REACTOME:R-HSA-9824585",
"REACTOME:R-MMU-5620916",
"REACTOME:R-MMU-8856825",
"REACTOME:R-MMU-8856828",
"REACTOME:R-MMU-8857538",
"REACTOME:R-RNO-8856825",
"REACTOME:R-RNO-8856828",
"REACTOM... | 12 | [
"1b4r",
"1ctn",
"1edq",
"1ehn",
"1eib",
"1ffq",
"1ffr",
"1k9t",
"1l0q",
"1nh6",
"1rd6",
"1wgo",
"1x6l",
"1x6n",
"2c26",
"2c4x",
"2kzw",
"2wk2",
"2wly",
"2wlz",
"2wm0",
"2y3u",
"2y50",
"2y6i",
"2y72",
"2yrl",
"4aqo",
"4jgu",
"4jrw",
"4l9d",
"4tn9",
"4u6t"... | 49 | [
"PUB00001323",
"PUB00014157",
"PUB00035973"
] | [
"9889186",
"12377130",
"11499680"
] | [
"The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.",
"Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins.",
"The genes for the human VPS10 domain-containing receptors are large and conta... | [
1999,
2002,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3545,
29129,
9399,
180,
539
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
35,
2,
1,
47,
16,
22
] | 6 | true | Domain | PKD/Chitinase domain | PKD/Chitinase domain | PKD/Chitinase_dom | 1 |
IPR022410 | 22,410 | ABC transporter, permease F420-0 | ABC_transptr_permease_F420-0 | Family | 324 | false | false | This small clade of ABC-type transporter permease protein components is found as a three gene cassette along with a periplasmic substrate-binding protein ( ) and an ATPase ( ). The organisms containing this cassette are all Actinobacteria and all contain numerous genes requiring the coenzyme F420. This model was define... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03869"
] | [
"F420-0_ABCperm"
] | [
324
] | 1 | [
"GP"
] | [
"GenProp0896"
] | [
"GP:GenProp0896"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR000522"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
324
] | 1 | [] | [] | 0 | true | Family | ABC transporter, permease F420-0 | ABC transporter, permease F420-0 | ABC_transptr_permease_F420-0 | 6 |
IPR022411 | 22,411 | C-type cytochrome, methanol metabolism-related | C-typ_cyt_methanol_metab-rel | Family | 655 | false | false | This entry represents a c-type cytochrome related to (but excluding) cytochrome c-555 of Methylococcus capsulatus. Members contain four invariant Cys residues, including two from a heme-binding motif shared with c-555, and two others. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03874"
] | [
"4cys_cytochr"
] | [
655
] | 1 | [
"GP"
] | [
"GenProp1101"
] | [
"GP:GenProp1101"
] | 1 | [
"6onq"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria",
"ecological metagenomes"
] | [
652,
3
] | 2 | [] | [] | 0 | true | Family | C-type cytochrome, methanol metabolism-related | C-type cytochrome, methanol metabolism-related | C-typ_cyt_methanol_metab-rel | 3 |
IPR022412 | 22,412 | Quinolinate phosphoribosyl transferase, N-terminal | Quinolinate_PRibosylTrfase_N | Domain | 27,328 | false | false | Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg 2+ to give rise to nicotinic acid mo... | [
"GO:0016763"
] | [
"pentosyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02749"
] | [
"QRPTase_N"
] | [
27328
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.2.19",
"PWY-5316",
"PWY-5653",
"PWY-7342",
"PWY-8277",
"PWY-8352",
"R-DDI-196807",
"R-HSA-196807",
"R-MMU-196807",
"R-RNO-196807",
"R-SCE-196807",
"R-SSC-196807"
] | [
"EC:2.4.2.19",
"METACYC:PWY-5316",
"METACYC:PWY-5653",
"METACYC:PWY-7342",
"METACYC:PWY-8277",
"METACYC:PWY-8352",
"REACTOME:R-DDI-196807",
"REACTOME:R-HSA-196807",
"REACTOME:R-MMU-196807",
"REACTOME:R-RNO-196807",
"REACTOME:R-SCE-196807",
"REACTOME:R-SSC-196807"
] | 12 | [
"1o4u",
"1qap",
"1qpn",
"1qpo",
"1qpq",
"1qpr",
"1x1o",
"1ytd",
"1yte",
"1ytk",
"2b7n",
"2b7p",
"2b7q",
"2i14",
"2i1o",
"2jbm",
"3c2e",
"3c2f",
"3c2o",
"3c2r",
"3c2v",
"3gnn",
"3l0g",
"3paj",
"3tqv",
"4i9a",
"4kwv",
"4kww",
"5ayx",
"5ayy",
"5ayz",
"5hul"... | 37 | [
"PUB00000163",
"PUB00005289"
] | [
"8561507",
"9016724"
] | [
"The sequencing expression, purification, and steady-state kinetic analysis of quinolinate phosphoribosyl transferase from Escherichia coli.",
"A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase."
] | [
1996,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1429,
22112,
3231,
556
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
6,
1,
2,
1,
2,
1,
11,
1,
4
] | 9 | true | Domain | Quinolinate phosphoribosyl transferase, N-terminal | Quinolinate phosphoribosyl transferase, N-terminal | Quinolinate_PRibosylTrfase_N | 3 |
IPR022413 | 22,413 | ATP:guanido phosphotransferase, N-terminal | ATP-guanido_PTrfase_N | Domain | 13,854 | false | false | This entry represents the N-terminal domain of ATP:guanido phosphotransferase, which has an all-α fold consisting of an irregular array of 6 short helices [ ]. ATP:guanido phosphotransferases are a family of structurally and functionally related enzymes [ , ] that reversibly catalyse the transfer of phosphate between A... | [
"GO:0016301",
"GO:0016772"
] | [
"kinase activity",
"transferase activity, transferring phosphorus-containing groups"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF02807",
"PS51509"
] | [
"ATP-gua_PtransN",
"PHOSPHAGEN_KINASE_N"
] | [
11308,
13826
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.3",
"R-BTA-71288",
"R-BTA-9696264",
"R-CFA-71288",
"R-CFA-9696264",
"R-GGA-71288",
"R-GGA-9696264",
"R-HSA-71288",
"R-HSA-9696264",
"R-MMU-71288",
"R-MMU-9696264",
"R-RNO-71288",
"R-RNO-9696264",
"R-SSC-71288"
] | [
"EC:2.7.3",
"REACTOME:R-BTA-71288",
"REACTOME:R-BTA-9696264",
"REACTOME:R-CFA-71288",
"REACTOME:R-CFA-9696264",
"REACTOME:R-GGA-71288",
"REACTOME:R-GGA-9696264",
"REACTOME:R-HSA-71288",
"REACTOME:R-HSA-9696264",
"REACTOME:R-MMU-71288",
"REACTOME:R-MMU-9696264",
"REACTOME:R-RNO-71288",
"REACT... | 14 | [
"1bg0",
"1crk",
"1g0w",
"1i0e",
"1m15",
"1p50",
"1p52",
"1qh4",
"1qk1",
"1rl9",
"1sd0",
"1u6r",
"1vrp",
"2crk",
"2j1q",
"3b6r",
"3drb",
"3dre",
"3jpz",
"3jq3",
"3ju5",
"3ju6",
"3l2d",
"3l2e",
"3m10",
"4am1",
"4bg4",
"4bhl",
"4gvy",
"4gvz",
"4gw0",
"4gw2"... | 66 | [
"PUB00000040",
"PUB00000670",
"PUB00002616",
"PUB00002619",
"PUB00019172"
] | [
"3896131",
"7819288",
"2324092",
"2324105",
"8692275"
] | [
"The creatine-creatine phosphate energy shuttle.",
"Isolation and sequence analysis of the gene for arginine kinase from the chelicerate arthropod, Limulus polyphemus: insights into catalytically important residues.",
"A cloned ATP:guanidino kinase in the trematode Schistosoma mansoni has a novel duplicated str... | [
1985,
1995,
1990,
1990,
1996
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
65,
13780,
9
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
5,
19,
9,
30,
12,
17,
1
] | 7 | true | Domain | ATP:guanido phosphotransferase, N-terminal | ATP:guanido phosphotransferase, N-terminal | ATP-guanido_PTrfase_N | 8 |
IPR022414 | 22,414 | ATP:guanido phosphotransferase, catalytic domain | ATP-guanido_PTrfase_cat | Domain | 22,751 | false | false | This entry represents the C-terminal catalytic domain of ATP:guanido phosphotransferase that consists of two similar subdomains, the common core of which comprises two β-α-β2-α repeats [ ]. The substrate binding site is located in the cleft between N and C-terminal subdomains, but most of the catalytic residues are fou... | [
"GO:0016301",
"GO:0016772"
] | [
"kinase activity",
"transferase activity, transferring phosphorus-containing groups"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF00217",
"PS51510"
] | [
"ATP-gua_Ptrans",
"PHOSPHAGEN_KINASE_C"
] | [
22232,
22507
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-71288",
"R-BTA-9696264",
"R-CFA-71288",
"R-CFA-9696264",
"R-GGA-71288",
"R-GGA-9696264",
"R-HSA-71288",
"R-HSA-9696264",
"R-MMU-71288",
"R-MMU-9696264",
"R-RNO-71288",
"R-RNO-9696264",
"R-SSC-71288"
] | [
"REACTOME:R-BTA-71288",
"REACTOME:R-BTA-9696264",
"REACTOME:R-CFA-71288",
"REACTOME:R-CFA-9696264",
"REACTOME:R-GGA-71288",
"REACTOME:R-GGA-9696264",
"REACTOME:R-HSA-71288",
"REACTOME:R-HSA-9696264",
"REACTOME:R-MMU-71288",
"REACTOME:R-MMU-9696264",
"REACTOME:R-RNO-71288",
"REACTOME:R-RNO-9696... | 13 | [
"1bg0",
"1crk",
"1g0w",
"1i0e",
"1m15",
"1p50",
"1p52",
"1qh4",
"1qk1",
"1rl9",
"1sd0",
"1u6r",
"1vrp",
"2crk",
"2j1q",
"3b6r",
"3drb",
"3dre",
"3jpz",
"3jq3",
"3ju5",
"3ju6",
"3l2d",
"3l2e",
"3m10",
"4am1",
"4bg4",
"4bhl",
"4gvy",
"4gvz",
"4gw0",
"4gw2"... | 73 | [
"PUB00000040",
"PUB00000670",
"PUB00002616",
"PUB00002619",
"PUB00019172",
"PUB00055520",
"PUB00055521",
"PUB00055522",
"PUB00055523"
] | [
"3896131",
"7819288",
"2324092",
"2324105",
"8692275",
"17932618",
"18064398",
"18499493",
"20121101"
] | [
"The creatine-creatine phosphate energy shuttle.",
"Isolation and sequence analysis of the gene for arginine kinase from the chelicerate arthropod, Limulus polyphemus: insights into catalytically important residues.",
"A cloned ATP:guanidino kinase in the trematode Schistosoma mansoni has a novel duplicated str... | [
1985,
1995,
1990,
1990,
1996,
2007,
2008,
2008,
2010
] | 9 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3,
3442,
19233,
73
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
6,
19,
9,
30,
10,
17,
1
] | 7 | true | Domain | ATP:guanido phosphotransferase, catalytic domain | ATP:guanido phosphotransferase, catalytic domain | ATP-guanido_PTrfase_cat | 6 |
IPR022415 | 22,415 | ATP:guanido phosphotransferase active site | ATP-guanido_PTrfase_AS | Active_site | 15,919 | false | false | This entry represents the conserved region surrounding a cysteine residue in the C-terminal catalytic domain that is implicated in the catalytic activity of these enzymes. C-terminal catalytic domain of ATP:guanido phosphotransferase, which is comprised of a duplication where the common core consists of two β-α-β2-α re... | [
"GO:0016301",
"GO:0016772"
] | [
"kinase activity",
"transferase activity, transferring phosphorus-containing groups"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PROSITE"
] | [
"PS00112"
] | [
"PHOSPHAGEN_KINASE"
] | [
15919
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-71288",
"R-BTA-9696264",
"R-CFA-71288",
"R-CFA-9696264",
"R-GGA-71288",
"R-GGA-9696264",
"R-HSA-71288",
"R-HSA-9696264",
"R-MMU-71288",
"R-MMU-9696264",
"R-RNO-71288",
"R-RNO-9696264",
"R-SSC-71288"
] | [
"REACTOME:R-BTA-71288",
"REACTOME:R-BTA-9696264",
"REACTOME:R-CFA-71288",
"REACTOME:R-CFA-9696264",
"REACTOME:R-GGA-71288",
"REACTOME:R-GGA-9696264",
"REACTOME:R-HSA-71288",
"REACTOME:R-HSA-9696264",
"REACTOME:R-MMU-71288",
"REACTOME:R-MMU-9696264",
"REACTOME:R-RNO-71288",
"REACTOME:R-RNO-9696... | 13 | [
"1bg0",
"1crk",
"1g0w",
"1i0e",
"1m15",
"1p50",
"1p52",
"1qh4",
"1qk1",
"1rl9",
"1u6r",
"1vrp",
"2crk",
"2j1q",
"3b6r",
"3drb",
"3dre",
"3jpz",
"3jq3",
"3ju5",
"3ju6",
"3m10",
"4am1",
"4bg4",
"4bhl",
"4gvy",
"4gvz",
"4gw0",
"4gw2",
"4q2r",
"4rf6",
"4rf7"... | 68 | [
"PUB00000040",
"PUB00000670",
"PUB00002616",
"PUB00002619",
"PUB00019172"
] | [
"3896131",
"7819288",
"2324092",
"2324105",
"8692275"
] | [
"The creatine-creatine phosphate energy shuttle.",
"Isolation and sequence analysis of the gene for arginine kinase from the chelicerate arthropod, Limulus polyphemus: insights into catalytically important residues.",
"A cloned ATP:guanidino kinase in the trematode Schistosoma mansoni has a novel duplicated str... | [
1985,
1995,
1990,
1990,
1996
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2493,
13385,
41
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
2,
18,
8,
14,
8,
17,
1
] | 7 | true | Active_site | ATP:guanido phosphotransferase active site | ATP:guanido phosphotransferase active site | ATP-guanido_PTrfase_AS | 2 |
IPR022416 | 22,416 | Prion/Doppel protein, beta-ribbon domain | Prion/Doppel_prot_b-ribbon_dom | Domain | 1,777 | false | false | This entry represents the C-terminal β-ribbon domain found in prion proteins [ ] and the prion-like Doppel proteins [ ]. This domain has a β-α-β-α(2) structure that contains an antiparallel β-ribbon. Prion protein (PrP-c) [ , , ] is a small glycoprotein found in high quantity in the brain of animals infected with certa... | [
"GO:0051260",
"GO:0016020"
] | [
"protein homooligomerization",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PROSITE",
"PROSITE"
] | [
"PF00377",
"PS00291",
"PS00706"
] | [
"Prion",
"PRION_1",
"PRION_2"
] | [
1765,
1252,
1104
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-163125",
"R-GGA-9609523",
"R-HSA-163125",
"R-HSA-419037",
"R-HSA-9609523",
"R-MMU-163125",
"R-MMU-9609523",
"R-RNO-9609523",
"R-SSC-9609523"
] | [
"REACTOME:R-GGA-163125",
"REACTOME:R-GGA-9609523",
"REACTOME:R-HSA-163125",
"REACTOME:R-HSA-419037",
"REACTOME:R-HSA-9609523",
"REACTOME:R-MMU-163125",
"REACTOME:R-MMU-9609523",
"REACTOME:R-RNO-9609523",
"REACTOME:R-SSC-9609523"
] | 9 | [
"1ag2",
"1b10",
"1dwy",
"1dwz",
"1dx0",
"1dx1",
"1e1g",
"1e1j",
"1e1p",
"1e1s",
"1e1u",
"1e1w",
"1fkc",
"1fo7",
"1g04",
"1h0l",
"1hjm",
"1hjn",
"1i17",
"1i4m",
"1lg4",
"1m25",
"1qlx",
"1qlz",
"1qm0",
"1qm1",
"1qm2",
"1qm3",
"1tpx",
"1tqb",
"1tqc",
"1u3m"... | 124 | [
"PUB00000114",
"PUB00001512",
"PUB00005333",
"PUB00009996",
"PUB00025897",
"PUB00027022"
] | [
"2572197",
"1916104",
"2908696",
"12354606",
"11524679",
"12595265"
] | [
"Scrapie prions.",
"Prions and prion proteins.",
"The scrapie agent and the prion hypothesis.",
"Prion diseases: pathogenesis and public health concerns.",
"Crystal structure of the human prion protein reveals a mechanism for oligomerization.",
"NMR structure of the human doppel protein."
] | [
1989,
1991,
1988,
2002,
2001,
2003
] | 6 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
1777
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
25,
12,
7
] | 3 | true | Domain | Prion/Doppel protein, beta-ribbon domain | Prion/Doppel protein, beta-ribbon domain | Prion/Doppel_prot_b-ribbon_dom | 7 |
IPR022417 | 22,417 | Porphobilinogen deaminase, N-terminal | Porphobilin_deaminase_N | Domain | 29,546 | false | false | Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway [ ]. The end-product, uroporphyrinogen III, is used to synthesise a number of important molecules, including vitamin B12, haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin [ ]. The first stage in tetrapyrrole synthesi... | [
"GO:0004418",
"GO:0033014"
] | [
"hydroxymethylbilane synthase activity",
"tetrapyrrole biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF01379"
] | [
"Porphobil_deam"
] | [
29546
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1.61",
"PWY-5188",
"PWY-5189",
"R-BTA-189451",
"R-HSA-189451",
"R-MMU-189451",
"R-RNO-189451",
"R-SCE-189451",
"R-SPO-189451"
] | [
"EC:2.5.1.61",
"METACYC:PWY-5188",
"METACYC:PWY-5189",
"REACTOME:R-BTA-189451",
"REACTOME:R-HSA-189451",
"REACTOME:R-MMU-189451",
"REACTOME:R-RNO-189451",
"REACTOME:R-SCE-189451",
"REACTOME:R-SPO-189451"
] | 9 | [
"1ah5",
"1gtk",
"1pda",
"1ypn",
"2ypn",
"3ecr",
"3eq1",
"4htg",
"4mlq",
"4mlv",
"5h6o",
"5m6r",
"5m7f",
"5ov4",
"5ov5",
"5ov6",
"7aaj",
"7aak",
"7ccx",
"7ccy",
"7ccz",
"7cd0",
"8pnd"
] | 23 | [
"PUB00009744",
"PUB00025374",
"PUB00029805",
"PUB00035496",
"PUB00035498",
"PUB00035502"
] | [
"11215515",
"12555854",
"1522882",
"17227226",
"16564539",
"16935474"
] | [
"Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.",
"Time-resolved and static-ensemble structural chemistry of hydroxymethylbilane synthase.",
"Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site.",
"Tetrapyrrole biosynthesis in higher p... | [
2000,
2003,
1992,
2007,
2006,
2006
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
761,
22631,
5774,
380
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
4,
4,
2,
1,
12,
6,
1,
2,
9,
1,
1,
13
] | 12 | true | Domain | Porphobilinogen deaminase, N-terminal | Porphobilinogen deaminase, N-terminal | Porphobilin_deaminase_N | 2 |
IPR022418 | 22,418 | Porphobilinogen deaminase, C-terminal | Porphobilinogen_deaminase_C | Domain | 28,084 | false | false | Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway [ ]. The end-product, uroporphyrinogen III, is used to synthesise a number of important molecules, including vitamin B12, haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin [ ]. The first stage in tetrapyrrole synthesi... | [
"GO:0004418",
"GO:0033014"
] | [
"hydroxymethylbilane synthase activity",
"tetrapyrrole biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF03900"
] | [
"Porphobil_deamC"
] | [
28084
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1.61",
"PWY-5188",
"PWY-5189",
"R-BTA-189451",
"R-HSA-189451",
"R-MMU-189451",
"R-RNO-189451",
"R-SCE-189451",
"R-SPO-189451"
] | [
"EC:2.5.1.61",
"METACYC:PWY-5188",
"METACYC:PWY-5189",
"REACTOME:R-BTA-189451",
"REACTOME:R-HSA-189451",
"REACTOME:R-MMU-189451",
"REACTOME:R-RNO-189451",
"REACTOME:R-SCE-189451",
"REACTOME:R-SPO-189451"
] | 9 | [
"1ah5",
"1gtk",
"1pda",
"1ypn",
"2ypn",
"3ecr",
"3eq1",
"4htg",
"4mlq",
"4mlv",
"5h6o",
"5m6r",
"5m7f",
"5ov4",
"5ov5",
"5ov6",
"7aaj",
"7aak",
"7ccx",
"7ccy",
"7ccz",
"7cd0",
"8pnd"
] | 23 | [
"PUB00009744",
"PUB00025374",
"PUB00029805",
"PUB00035496",
"PUB00035498",
"PUB00035502"
] | [
"11215515",
"12555854",
"1522882",
"17227226",
"16564539",
"16935474"
] | [
"Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.",
"Time-resolved and static-ensemble structural chemistry of hydroxymethylbilane synthase.",
"Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site.",
"Tetrapyrrole biosynthesis in higher p... | [
2000,
2003,
1992,
2007,
2006,
2006
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
714,
21731,
5341,
298
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
4,
4,
2,
1,
7,
5,
1,
2,
7,
1,
1,
11
] | 12 | true | Domain | Porphobilinogen deaminase, C-terminal | Porphobilinogen deaminase, C-terminal | Porphobilinogen_deaminase_C | 7 |
IPR022419 | 22,419 | Porphobilinogen deaminase, dipyrromethane cofactor binding site | Porphobilin_deaminase_cofac_BS | Binding_site | 25,292 | false | false | This entry represents the region around a cysteine residues that is conserved in porphobilinogen deaminases from various prokaryotic and eukaryotic sources. The sulphur atom of this cysteine residue has been shown in the Escherichia coli enzyme (gene hemC) to be bound to the dipyrromethane cofactor [ ]. Porphobilinogen... | [
"GO:0004418",
"GO:0018160",
"GO:0033014"
] | [
"hydroxymethylbilane synthase activity",
"peptidyl-pyrromethane cofactor linkage",
"tetrapyrrole biosynthetic process"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PROSITE"
] | [
"PS00533"
] | [
"PORPHOBILINOGEN_DEAM"
] | [
25292
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1.61",
"PWY-5188",
"PWY-5189",
"R-BTA-189451",
"R-HSA-189451",
"R-MMU-189451",
"R-RNO-189451",
"R-SCE-189451",
"R-SPO-189451"
] | [
"EC:2.5.1.61",
"METACYC:PWY-5188",
"METACYC:PWY-5189",
"REACTOME:R-BTA-189451",
"REACTOME:R-HSA-189451",
"REACTOME:R-MMU-189451",
"REACTOME:R-RNO-189451",
"REACTOME:R-SCE-189451",
"REACTOME:R-SPO-189451"
] | 9 | [
"1ah5",
"1gtk",
"1pda",
"1ypn",
"2ypn",
"3ecr",
"3eq1",
"4htg",
"4mlq",
"4mlv",
"5h6o",
"5m6r",
"5m7f",
"5ov4",
"5ov5",
"5ov6",
"7aaj",
"7aak",
"7ccx",
"7ccy",
"7ccz",
"7cd0",
"8pnd"
] | 23 | [
"PUB00000469",
"PUB00029805"
] | [
"3196304",
"1522882"
] | [
"Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242.",
"Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site."
] | [
1988,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
541,
19772,
4767,
212
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
4,
4,
2,
1,
7,
5,
1,
2,
7,
1,
1,
11
] | 12 | true | Binding_site | Porphobilinogen deaminase, dipyrromethane cofactor binding site | Porphobilinogen deaminase, dipyrromethane cofactor binding site | Porphobilin_deaminase_cofac_BS | 4 |
IPR022420 | 22,420 | Circadian clock protein, KaiC, methanobacteria | Circ_KaiC_methanobact | Family | 329 | false | false | This entry represents a rather narrowly distributed methanobacterial protein family in which members have a single copy of the KaiC domain. This stands in contrast to the circadian clock protein KaiC itself, with two copies of the domain. Members are expected to have weak ATPase activity, by homology to the autokinase/... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03880"
] | [
"KaiC_arch_3"
] | [
329
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Methanobacteriati",
"ecological metagenomes"
] | [
327,
2
] | 2 | [] | [] | 0 | true | Family | Circadian clock protein, KaiC, methanobacteria | Circadian clock protein, KaiC, methanobacteria | Circ_KaiC_methanobact | 1 |
IPR022421 | 22,421 | Relaxin | Relaxin | Family | 208 | false | false | The insulin/IGF/relaxin superfamily is an ancient family of functionally diverse proteins [ ]. The 3D structures of a number of family members have been determined [ , , ]. The fold comprises two polypeptide chains (A and B) linked by two disulphide bonds: all share a conserved arrangement of four cysteines in their A ... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR02004"
] | [
"RELAXIN"
] | [
208
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-418555",
"R-HSA-444821",
"R-MMU-418555",
"R-MMU-444821",
"R-RNO-444821"
] | [
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-444821",
"REACTOME:R-MMU-418555",
"REACTOME:R-MMU-444821",
"REACTOME:R-RNO-444821"
] | 5 | [] | 0 | [
"PUB00003970",
"PUB00003972",
"PUB00003973",
"PUB00023078",
"PUB00037375",
"PUB00053639",
"PUB00053640",
"PUB00053641",
"PUB00053642",
"PUB00053683",
"PUB00096674"
] | [
"503234",
"6243748",
"6107857",
"2036417",
"9141131",
"10601981",
"8735594",
"8683595",
"1319992",
"6298628",
"30747102"
] | [
"Nucleotide sequence of a cDNA clone encoding human preproinsulin.",
"Sequence of the human insulin gene.",
"Hormone families: pancreatic hormones and homologous growth factors.",
"Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.",... | [
1979,
1980,
1980,
1991,
1997,
1999,
1996,
1996,
1992,
1983,
2019
] | 11 | [] | [
"IPR023258"
] | 0 | 1 | 0 | [
"Theria"
] | [
208
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
3
] | 3 | true | Family | Relaxin | Relaxin | Relaxin | 4 |
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