LiteFold/InterPro · Datasets at Hugging Face

IPR022910

22,910

Thiol:disulphide interchange protein DsbD

Thiol_diS_interchange_DbsD

Family

5,760

false

This entry represents the thiol:disulphide interchange protein, DsbD (also known as DipZ). These proteins are thought to facilitate the correct formation of disufide bonds in some periplasmic proteins, as well as for the assembly of the periplasmic c-type cytochromes [ , ]. DsbD acts by transferring electrons from cyto...

[ "GO:0047134" ]

[ "protein-disulfide reductase [NAD(P)H] activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00399" ]

[ "DbsD" ]

[ 5760 ]

1

[ "EC" ]

[ "1.8.1.8" ]

[ "EC:1.8.1.8" ]

1

[]

0

[ "PUB00008277", "PUB00067666", "PUB00067667", "PUB00067672" ]

[ "7623667", "10712691", "11085993", "11114333" ]

[ "The biogenesis of c-type cytochromes in Escherichia coli requires a membrane-bound protein, DipZ, with a protein disulphide isomerase-like domain.", "Transfer of electrons across the cytoplasmic membrane by DsbD, a membrane protein involved in thiol-disulphide exchange and protein folding in the bacterial peripl...

[ 1995, 2000, 2001, 2000 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5701, 3, 56 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Thiol:disulphide interchange protein DsbD

Thiol_diS_interchange_DbsD

1

IPR022911

22,911

Phenylalanine-tRNA ligase alpha chain 1, bacterial

Phe_tRNA_ligase_alpha1_bac

Family

24,601

false

Phenylalanine-tRNA ligase ( ) is a tetramer of two alpha and two beta chains. This family represents the type 1 alpha chain from bacteria. Aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of amino acids to their cognate transfer RNA molecules through a highly specific two-step r...

[ "GO:0004826" ]

[ "phenylalanine-tRNA ligase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00281" ]

[ "Phe_tRNA_synth_alpha1" ]

[ 24601 ]

1

[ "EC" ]

[ "6.1.1.20" ]

[ "EC:6.1.1.20" ]

1

[ "1b70", "1b7y", "1eiy", "1jjc", "1pys", "2iy5", "2rhq", "2rhs", "3hfz", "3pco", "3teh", "4p71", "4p72", "4p73", "4p74", "4p75", "4tva", "6oz5", "6p24", "6p26", "6p8t", "7daw", "7db7", "7db8", "7k98", "7k9m", "7ka0", "7kab", "7n8y", "9drs", "9drt", "9drv"...

34

[ "PUB00000386", "PUB00000723", "PUB00004391", "PUB00005365", "PUB00006477", "PUB00007191", "PUB00007363", "PUB00079872", "PUB00079873" ]

[ "8364025", "8274143", "1852601", "2053131", "10673435", "2203971", "10447505", "10704480", "12458790" ]

[ "Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.", "The aminoacyl-tRNA synthetase family: modules at work.", "Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.", "Classes of aminoacyl-tRNA synthetases and the establ...

[ 1993, 1993, 1991, 1991, 2000, 1990, 1999, 2000, 2002 ]

9

[ "IPR004529" ]

[]

1

0

1

[ "Bacteria", "Candidatus Nitrosopumilus salarius BD31", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 24066, 1, 98, 1, 435 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phenylalanine-tRNA ligase alpha chain 1, bacterial

Phe_tRNA_ligase_alpha1_bac

5

IPR022914

22,914

Protein of unknown function UPF0397

UPF0397

Family

1,410

false

The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP" ]

[ "MF_01572" ]

[ "UPF0397" ]

[ 1410 ]

1

[]

0

[]

0

[]

0

[ "IPR009825" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 1407, 3 ]

2

[]

0

true

Family

Protein of unknown function UPF0397

UPF0397

7

IPR022915

22,915

Peroxiredoxin, TDXH subfamily

Peroxiredoxin_TDXH

Family

2,100

false

Peroxiredoxins are thiol-dependent peroxidases that play an important role in antioxidant defence mechanisms by removing hydrogen peroxide. This group of peroxiredoxins is represented by peroxiredoxins from Pyrococcus horikoshii (PhPrx) [ ] and Aeropyrum pernix (ApPrx) [ ]. They have a similar structure, though ApPrx h...

[ "GO:0051920" ]

[ "peroxiredoxin activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00401" ]

[ "Peroxiredoxin" ]

[ 2100 ]

1

[ "EC" ]

[ "1.11.1.24" ]

[ "EC:1.11.1.24" ]

1

[ "1x0r", "2cv4", "2e2g", "2e2m", "2nvl", "2zct", "3a2v", "3a2w", "3a2x", "3a5w", "3w6g", "5ovq", "5xbq", "5xbr", "5xbs", "6itz", "6iu0", "6iu1", "6krk", "6krm", "6krp", "6krq", "6krr", "6krs", "6q5v", "7c87", "7c89", "7c8a", "7cqj", "8hh0", "8hla" ]

31

[ "PUB00074096", "PUB00074097", "PUB00074098" ]

[ "12707274", "15625325", "23832195" ]

[ "Characterization of novel hexadecameric thioredoxin peroxidase from Aeropyrum pernix K1.", "Oxidative stress response in an anaerobic hyperthermophilic archaeon: presence of a functional peroxiredoxin in Pyrococcus horikoshii.", "Structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococc...

[ 2003, 2004, 2013 ]

3

[ "IPR045020" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 488, 1566, 3, 43 ]

4

[]

0

true

Family

Peroxiredoxin, TDXH subfamily

Peroxiredoxin_TDXH

5

IPR022916

22,916

Protein of unknown function UPF0349

UPF0349

Family

670

false

The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP" ]

[ "MF_01542" ]

[ "UPF0349" ]

[ 670 ]

1

[]

0

[]

0

[]

0

[ "IPR009910" ]

[]

1

0

1

[ "Bacillales" ]

[ 670 ]

1

[]

0

true

Family

Protein of unknown function UPF0349

UPF0349

8

IPR022917

22,917

Phenylalanine-tRNA ligase alpha subunit, bacterial/archaeal

Phe_tRNA_ligase_alpha_bac/arc

Family

769

false

Phenylalanine-tRNA ligase ( ) is a tetramer of two alpha and two beta subunits. This entry represents the type 2 alpha subunit from bacteria and archaea. Aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of amino acids to their cognate transfer RNA molecules through a highly spec...

[ "GO:0004826" ]

[ "phenylalanine-tRNA ligase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00282" ]

[ "Phe_tRNA_synth_alpha2" ]

[ 769 ]

1

[ "EC" ]

[ "6.1.1.20" ]

[ "EC:6.1.1.20" ]

1

[]

0

[ "PUB00000386", "PUB00000723", "PUB00004391", "PUB00005365", "PUB00006477", "PUB00007191", "PUB00007363", "PUB00079872", "PUB00079873" ]

[ "8364025", "8274143", "1852601", "2053131", "10673435", "2203971", "10447505", "10704480", "12458790" ]

[ "Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.", "The aminoacyl-tRNA synthetase family: modules at work.", "Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.", "Classes of aminoacyl-tRNA synthetases and the establ...

[ 1993, 1993, 1991, 1991, 2000, 1990, 1999, 2000, 2002 ]

9

[ "IPR004529" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 705, 54, 10 ]

3

[]

0

true

Family

Phenylalanine-tRNA ligase alpha subunit, bacterial/archaeal

Phe_tRNA_ligase_alpha_bac/arc

3

IPR022918

22,918

Phenylalanine-tRNA ligase beta chain 2, archaeal type

Phe_tRNA_ligase_beta2_arc

Family

844

false

Phenylalanine-tRNA ligase (also known as Phenylalanyl-tRNA synthetase) ( ) is a tetramer of two alpha and two beta chains. This entry represents the type 2 beta chain from bacteria and archaea. Aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of amino acids to their cognate tran...

[ "GO:0004826", "GO:0006432" ]

[ "phenylalanine-tRNA ligase activity", "phenylalanyl-tRNA aminoacylation" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_00284" ]

[ "Phe_tRNA_synth_beta2" ]

[ 844 ]

1

[ "EC" ]

[ "6.1.1.20" ]

[ "EC:6.1.1.20" ]

1

[]

0

[ "PUB00000386", "PUB00000723", "PUB00004391", "PUB00005365", "PUB00006477", "PUB00007191", "PUB00007363", "PUB00079872", "PUB00079873" ]

[ "8364025", "8274143", "1852601", "2053131", "10673435", "2203971", "10447505", "10704480", "12458790" ]

[ "Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.", "The aminoacyl-tRNA synthetase family: modules at work.", "Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.", "Classes of aminoacyl-tRNA synthetases and the establ...

[ 1993, 1993, 1991, 1991, 2000, 1990, 1999, 2000, 2002 ]

9

[ "IPR004531" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 733, 101, 10 ]

3

[]

0

true

Family

Phenylalanine-tRNA ligase beta chain 2, archaeal type

Phe_tRNA_ligase_beta2_arc

7

IPR022919

22,919

Peptidase M48, protease HtpX, putative

Pept_M48_protease_HtpX

Family

17,899

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0004222" ]

[ "metalloendopeptidase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00188" ]

[ "Pept_M48_protease_HtpX" ]

[ 17899 ]

1

[ "EC", "METACYC" ]

[ "3.4.24.-", "PWY-8119" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119" ]

2

[]

0

[ "PUB00003579", "PUB00014962", "PUB00033915" ]

[ "7674922", "12081643", "16076848" ]

[ "Evolutionary families of metallopeptidases.", "The Cpx stress response system of Escherichia coli senses plasma membrane proteins and controls HtpX, a membrane protease with a cytosolic active site.", "Proteolytic activity of HtpX, a membrane-bound and stress-controlled protease from Escherichia coli." ]

[ 1995, 2002, 2005 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 970, 16646, 19, 264 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Peptidase M48, protease HtpX, putative

Pept_M48_protease_HtpX

1

IPR022920

22,920

Disulphide bond formation protein DsbB

Disulphide_bond_form_DsbB

Family

6,052

false

Disulphide bonds contribute to folding, maturation, stability, and regulation of proteins, in particular those localized out of the cytosol. Oxidation of selected pairs of cysteines to disulphide in vivo requires cellular factors present in the bacterial periplasmic space or in the endoplasmic reticulum of eukaryotic c...

[]

0

[ "HAMAP" ]

[ "MF_00286" ]

[ "DsbB" ]

[ 6052 ]

1

[]

0

[ "2hi7", "2k73", "2k74", "2leg", "2ltq", "2zup", "2zuq", "3e9j", "6wvf" ]

9

[ "PUB00008228", "PUB00008229", "PUB00014003", "PUB00054232" ]

[ "8430071", "7957076", "12524212", "12415301" ]

[ "A pathway for disulfide bond formation in vivo.", "Two cysteines in each periplasmic domain of the membrane protein DsbB are required for its function in protein disulfide bond formation.", "Protein disulfide bond formation in prokaryotes.", "Formation and transfer of disulphide bonds in living cells." ]

[ 1993, 1994, 2003, 2002 ]

4

[ "IPR003752" ]

[]

1

0

1

[ "Bacteria", "Knufia peltigerae", "unclassified sequences" ]

[ 6013, 1, 38 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Disulphide bond formation protein DsbB

Disulphide_bond_form_DsbB

3

IPR022921

22,921

Methionine synthase MetE, archaeal

MetE_arc

Family

206

false

This entry represents methionine synthase MetE from Archaea. It catalyses the formation of methionine from methylcobalamin and homocysteine and belongs the vitamin-B12 (cobalamin) independent methionine synthase family [ ].

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00288" ]

[ "MetE" ]

[ 206 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[]

0

[ "PUB00070292" ]

[ "10469143" ]

[ "Methylcobalamin:homocysteine methyltransferase from Methanobacterium thermoautotrophicum. Identification as the metE gene product." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria" ]

[ 202, 4 ]

2

[]

0

true

Family

Methionine synthase MetE, archaeal

MetE_arc

3

IPR022924

22,924

Cardiolipin synthase

Cardiolipin_synthase

Family

18,519

false

Most bacteria use an enzyme belonging to the phospholipase D family as cardiolipin synthase. In contrast, eukaryotes and most actinobacteria use a cardiolipin synthase of the CDP-alcohol phosphatidyltransferase family [ ]. This entry represents cardiolipin (CL) synthases that belong to the phospholipase D family. They ...

[ "GO:0008808", "GO:0016780", "GO:0032049" ]

[ "cardiolipin synthase activity", "phosphotransferase activity, for other substituted phosphate groups", "cardiolipin biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR04265" ]

[ "bac_cardiolipin" ]

[ 18519 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.8.-", "GenProp1627", "PWY-6350", "PWY-6580", "PWY-6804", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-7819", "PWY-7820", "PWY-7981", "PWY-8248" ]

[ "EC:2.7.8.-", "GP:GenProp1627", "METACYC:PWY-6350", "METACYC:PWY-6580", "METACYC:PWY-6804", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-7819", "METACYC:PWY-7820", "METACYC:PWY-7981", "METACYC:PWY-8248" ]

13

[]

0

[ "PUB00053945", "PUB00053993", "PUB00074103" ]

[ "9370333", "19439403", "14973018" ]

[ "Cardiolipin synthase from Escherichia coli.", "A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria.", "Cardiolipin domains in Bacillus subtilis marburg membranes." ]

[ 1997, 2009, 2004 ]

3

[]

[ "IPR030840", "IPR030874" ]

0

2

0

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 18337, 16, 63, 103 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cardiolipin synthase

Cardiolipin_synthase

8

IPR022925

22,925

NAD-capped RNA hydrolase NudC

RNA_Hydrolase_NudC

Family

2,860

false

This entry represents NAD-capped RNA hydrolase NudC from bacteria. NudC is a mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolysing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. This enzyme h...

[ "GO:0000210" ]

[ "NAD+ diphosphatase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00297" ]

[ "Nudix_NudC" ]

[ 2860 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.6.1.-", "3.6.1.22", "PWY-5381", "PWY-5757", "PWY-6147", "PWY-6383", "PWY-6797", "PWY-7206", "PWY-7419", "PWY-7539", "PWY-7719", "PWY-7761", "PWY-7821", "PWY-8289" ]

[ "EC:3.6.1.-", "EC:3.6.1.22", "METACYC:PWY-5381", "METACYC:PWY-5757", "METACYC:PWY-6147", "METACYC:PWY-6383", "METACYC:PWY-6797", "METACYC:PWY-7206", "METACYC:PWY-7419", "METACYC:PWY-7539", "METACYC:PWY-7719", "METACYC:PWY-7761", "METACYC:PWY-7821", "METACYC:PWY-8289" ]

14

[ "1vk6", "2gb5", "5isy", "5iw4", "5iw5", "7e44" ]

6

[ "PUB00095660", "PUB00100519" ]

[ "27428510", "27561816" ]

[ "Structure and function of the bacterial decapping enzyme NudC.", "Structural basis of prokaryotic NAD-RNA decapping by NudC." ]

[ 2016, 2016 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "ecological metagenomes" ]

[ 2824, 3, 26, 7 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

NAD-capped RNA hydrolase NudC

RNA_Hydrolase_NudC

7

IPR022926

22,926

NH(3)-dependent NAD(+) synthetase

NH(3)-dep_NAD(+)_synth

Family

11,210

false

This entry represents NH(3)-dependent NAD(+) synthetases from prokaryotes. NAD+ is involved electron transport and redox reactions and in DNA ligation and protein ADP-ribosylation. In yeast and most other organisms, NAD is generated through the de novo pathway and the salvage pathway. In the de novo pathway, quinolinic...

[ "GO:0008795", "GO:0009435" ]

[ "NAD+ synthase activity", "NAD+ biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_00193" ]

[ "NadE_ammonia_dep" ]

[ 11210 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "6.3.1.5", "PWY-7761", "PWY-8277", "PWY-8352" ]

[ "EC:6.3.1.5", "METACYC:PWY-7761", "METACYC:PWY-8277", "METACYC:PWY-8352" ]

4

[ "1ee1", "1fyd", "1ifx", "1ih8", "1kqp", "1nsy", "1wxe", "1wxf", "1wxg", "1wxh", "1wxi", "1xng", "1xnh", "2e18", "2nsy", "2pz8", "2pza", "2pzb", "3dpi", "3fiu", "3hmq", "3p52", "3q4g", "4q16", "4xfd", "5f23", "5huh", "5huj", "5wp0", "6c8q", "6kv3" ]

31

[ "PUB00070122", "PUB00070123", "PUB00070124" ]

[ "12898714", "7890752", "12771147" ]

[ "Saccharomyces cerevisiae QNS1 codes for NAD(+) synthetase that is functionally conserved in mammals.", "The outB gene of Bacillus subtilis codes for NAD synthetase.", "Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase." ]

[ 2003, 1995, 2003 ]

3

[ "IPR003694" ]

[]

1

0

1

[ "Archaea", "Bacillus phage G", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 885, 1, 10257, 5, 62 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

NH(3)-dependent NAD(+) synthetase

NH(3)-dep_NAD(+)_synth

9

IPR022927

22,927

RNA pyrophosphohydrolase RppH

RppH

Family

10,816

false

This entry represents an RNA pyrophosphohydrolase belonging to the nudix hydrolase family, RppH subfamily which includes RppH from bacteria and NUD25-27 from plants. RppH accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphory...

[]

0

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00298", "NF001938", "cd03671" ]

[ "Nudix_RppH", "PRK00714.1-5", "NUDIX_Ap4A_hydrolase_plant_like" ]

[ 9636, 10727, 10733 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.6.1.-", "PWY-5757", "PWY-6147", "PWY-6383", "PWY-6797", "PWY-7206", "PWY-7419", "PWY-7539", "PWY-7719", "PWY-7821", "PWY-8289" ]

[ "EC:3.6.1.-", "METACYC:PWY-5757", "METACYC:PWY-6147", "METACYC:PWY-6383", "METACYC:PWY-6797", "METACYC:PWY-7206", "METACYC:PWY-7419", "METACYC:PWY-7539", "METACYC:PWY-7719", "METACYC:PWY-7821", "METACYC:PWY-8289" ]

11

[ "1f3y", "1jkn", "2kdv", "2kdw", "4s2v", "4s2w", "4s2x", "4s2y", "5ygu", "6d13", "6d1q", "6d1v", "6vck", "6vcl", "6vcm", "6vcn", "6vco", "6vcp", "6vcq", "6vcr", "7sp3" ]

21

[ "PUB00046111", "PUB00070213", "PUB00158845" ]

[ "18202662", "18815383", "18345354" ]

[ "The bacterial enzyme RppH triggers messenger RNA degradation by 5' pyrophosphate removal.", "Molecular characterization of organelle-type Nudix hydrolases in Arabidopsis.", "A diadenosine 5',5''-P1P4 tetraphosphate (Ap4A) hydrolase from Arabidopsis thaliana that is activated preferentially by Mn2+ ions." ]

[ 2008, 2008, 2008 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanospirillum lacunae", "unclassified sequences" ]

[ 9391, 1287, 1, 137 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 1, 4, 5 ]

4

true

Family

RNA pyrophosphohydrolase RppH

RppH

8

IPR022928

22,928

RNA 2'-phosphotransferase KptA, putative

RNA_2'-PTrans_KptA

Family

4,573

false

This entry represents KptA, a putative RNA 2'-phosphotransferase. KptA, a functional Tpt1 protein homologue from Escherichia coli is strikingly similar to yeast Tpt1 in its kinetic parameters, although E. coli is not known to have a 2'-phosphorylated RNA substrate [ , ].

[ "GO:0003950" ]

[ "NAD+ poly-ADP-ribosyltransferase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00299" ]

[ "KptA" ]

[ 4573 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.-", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-6626", "PWY-6682", "PWY-6955", "PWY-7077", "PWY-7321", "PWY-7740", "PWY-7769", "PWY-7886", "PWY-7948", "PWY-7975", "PWY-8129", "PWY-8324", "PWY-8367", "PWY-8392", "PWY-8393", "PWY-8394", "PWY-8402" ]

[ "EC:2.7.1.-", "METACYC:PWY-5129", "METACYC:PWY-6322", "METACYC:PWY-6369", "METACYC:PWY-6626", "METACYC:PWY-6682", "METACYC:PWY-6955", "METACYC:PWY-7077", "METACYC:PWY-7321", "METACYC:PWY-7740", "METACYC:PWY-7769", "METACYC:PWY-7886", "METACYC:PWY-7948", "METACYC:PWY-7975", "METACYC:PWY-8...

21

[ "1wfx", "6e3a", "6ede", "7kw8", "7kw9", "8tfi", "8tfx", "8tfy", "8tfz", "8tg3", "8tg4", "8tg5", "8tg6", "8tkb", "9ld3", "9ld4", "9ld6", "9lda", "9ldc", "9ldd", "9lde", "9ldf", "9ldg", "9ldh", "9ldi" ]

25

[ "PUB00008050", "PUB00009787" ]

[ "9915792", "11705403" ]

[ "Transient ADP-ribosylation of a 2'-phosphate implicated in its removal from ligated tRNA during splicing in yeast.", "Substrate recognition by a yeast 2'-phosphotransferase involved in tRNA splicing and by its Escherichia coli homolog." ]

[ 1999, 2001 ]

2

[ "IPR002745" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 321, 4173, 24, 35, 20 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RNA 2'-phosphotransferase KptA, putative

RNA_2'-PTrans_KptA

4

IPR022929

22,929

Manganese exporter MntP

MntP

Family

7,050

false

This entry represents Manganese exporter MntP [ ]. Escherichia coli MntP (formerly YebN), is upregulated by manganese through transcriptional regulator MntR. It functions as a manganese exporter. It is involved in manganese homeostasis. It is important for reducing the concentration of manganese in the cell when mangan...

[]

0

[ "HAMAP" ]

[ "MF_01521" ]

[ "MntP_pump" ]

[ 7050 ]

1

[]

0

[]

0

[ "PUB00064727" ]

[ "21908668" ]

[ "The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis." ]

[ 2011 ]

1

[ "IPR003810" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Fungi", "metagenomes" ]

[ 142, 6829, 7, 72 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Manganese exporter MntP

MntP

5

IPR022930

22,930

Protein of unknown function UPF0316

UPF0316

Family

2,810

false

The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP", "PANTHER" ]

[ "MF_01515", "PTHR40060" ]

[ "UPF0316", "" ]

[ 2461, 2810 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 2712, 2, 54, 42 ]

4

[]

0

true

Family

Protein of unknown function UPF0316

UPF0316

3

IPR022932

22,932

Putative phosphoesterase YjcG

YjcG

Family

1,232

false

The proteins in this entry are functionally uncharacterised but contains a phosphoesterase HXTX domain found in a number of known and predicted phosphoesterases.

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01444", "NF010223" ]

[ "2H_phosphoesterase_YjcG", "PRK13679.1" ]

[ 1193, 1232 ]

2

[]

0

[ "2d4g" ]

1

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 1231, 1 ]

2

[]

0

true

Family

Putative phosphoesterase YjcG

YjcG

4

IPR022933

22,933

Uncharacterised protein family UPF0353

UPF0353

Family

377

false

The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP" ]

[ "MF_01340" ]

[ "UPF0353" ]

[ 377 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycobacteriales" ]

[ 377 ]

1

[]

0

true

Family

Uncharacterised protein family UPF0353

UPF0353

3

IPR022934

22,934

Manganese-dependent inorganic pyrophosphatase, probable

Mn-dep_inorganic_PyrPase

Family

2,565

false

This entry represents probable manganese-dependent inorganic pyrophosphatases that belong to the PPase class C family. This entry includes Manganese-dependent inorganic pyrophosphatase from Methanocaldococcus jannaschii that is characterised [ ].

[ "GO:0004427" ]

[ "inorganic diphosphate phosphatase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00207" ]

[ "PPase_C" ]

[ 2565 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "3.6.1.1", "PWY-7805", "PWY-7807" ]

[ "EC:3.6.1.1", "METACYC:PWY-7805", "METACYC:PWY-7807" ]

3

[ "1i74", "1k20", "1k23", "1wpm", "1wpp", "2eb0", "2enx", "2haw", "2iw4", "4rpa" ]

10

[ "PUB00070814" ]

[ "10898947" ]

[ "Methanococcus jannaschii ORF mj0608 codes for a class C inorganic pyrophosphatase protected by Co(2+) or Mn(2+) ions against fluoride inhibition." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriota" ]

[ 2547, 18 ]

2

[]

0

true

Family

Manganese-dependent inorganic pyrophosphatase, probable

Mn-dep_inorganic_PyrPase

9

IPR022936

22,936

Uncharacterised protein family UPF0194, membrane protein YbhG

UPF0194_membrane_YbhG

Family

761

false

The proteins in this entry are functionally uncharacterised, but are related to the secretion protein HlyD.

[]

0

[ "HAMAP" ]

[ "MF_01304" ]

[ "UPF0194" ]

[ 761 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota" ]

[ 761 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0194, membrane protein YbhG

UPF0194_membrane_YbhG

2

IPR022937

22,937

Mevalonate kinase, archaeal

Mevalonate_kinase_arc

Family

774

false

Mevalonate kinase ( ) is well-characterised among the Eukaryotes, where it plays a role in the synthesis of isopentanyl pyrophosphate, a common intermediate for a number of pathways including cholesterol biosynthesis. It is also involved in mevalonate catabolism. Close homologues are found in the Archaea. A bacterial e...

[ "GO:0004496" ]

[ "mevalonate kinase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00217" ]

[ "Mevalonate_kinase" ]

[ 774 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.36", "PWY-6174", "PWY-7391", "PWY-8125", "PWY-922" ]

[ "EC:2.7.1.36", "METACYC:PWY-6174", "METACYC:PWY-7391", "METACYC:PWY-8125", "METACYC:PWY-922" ]

5

[ "1kkh", "1vis", "4hac", "6mde", "6mdf", "8teb" ]

6

[]

0

[ "IPR006205" ]

[]

1

0

1

[ "Archaea", "ecological metagenomes" ]

[ 769, 5 ]

2

[]

0

true

Family

Mevalonate kinase, archaeal

Mevalonate_kinase_arc

4

IPR022938

22,938

Signal recognition particle, SRP19 subunit, archaeal-type

SRP19_arc-type

Family

902

false

This entry represents the SRP19 subunit in Archaea and Fungi. In Fungi it is known as SEC65 subunit. The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, o...

[]

0

[ "HAMAP" ]

[ "MF_00305" ]

[ "SRP19" ]

[ 902 ]

1

[ "REACTOME" ]

[ "R-SCE-1799339" ]

[ "REACTOME:R-SCE-1799339" ]

1

[ "1kvn", "1kvv", "1l9a", "1lng", "2v3c", "3dlu", "3dlv", "3ktw", "3ndb", "4xco" ]

10

[ "PUB00028143", "PUB00035998", "PUB00035999", "PUB00053948", "PUB00063486", "PUB00100261" ]

[ "16469117", "17622352", "17507650", "12364595", "12605305", "34020957" ]

[ "Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages.", "X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.", "The signal recognition particle (SRP) RNA links conformational changes in the SRP to pro...

[ 2006, 2007, 2007, 2002, 2003, 2021 ]

6

[ "IPR002778" ]

[]

1

0

1

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 709, 182, 11 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Signal recognition particle, SRP19 subunit, archaeal-type

SRP19_arc-type

7

IPR022939

22,939

Nitrobindin, bacteria/plant

Nb(III)_bact/plant

Family

4,796

false

This entry includes the Nitrobindin family members mostly from bacteria and plants. Mycobacterium tuberculosis Nb (Mt-Nb(III) is a peroxynitrite isomerase, which is a heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite...

[]

0

[ "HAMAP" ]

[ "MF_01297" ]

[ "nitrobindin" ]

[ 4796 ]

1

[]

0

[ "2fr2", "2fwv", "6r3w", "6r3y" ]

4

[ "PUB00099650" ]

[ "32295384" ]

[ "Mycobacterial and Human Nitrobindins: Structure and Function." ]

[ 2020 ]

1

[ "IPR045165" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4622, 67, 107 ]

3

[]

0

true

Family

Nitrobindin, bacteria/plant

Nb(III)_bact/plant

5

IPR022941

22,941

Signal recognition particle, SRP54 subunit

SRP54

Family

33,210

false

This entry represents the SRP54 subunit of the signal recognition particle protein translocation system. The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryote...

[ "GO:0003924", "GO:0005525", "GO:0006614", "GO:0048500" ]

[ "GTPase activity", "GTP binding", "SRP-dependent cotranslational protein targeting to membrane", "signal recognition particle" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "HAMAP", "PANTHER" ]

[ "MF_00306", "PTHR11564" ]

[ "SRP54", "" ]

[ 29438, 33196 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.5.4", "R-BTA-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-DRE-1799339", "R-HSA-1799339", "R-MMU-1799339", "R-RNO-1799339", "R-SCE-1799339", "R-SPO-1799339" ]

[ "EC:3.6.5.4", "REACTOME:R-BTA-1799339", "REACTOME:R-CFA-1799339", "REACTOME:R-DDI-1799339", "REACTOME:R-DRE-1799339", "REACTOME:R-HSA-1799339", "REACTOME:R-MMU-1799339", "REACTOME:R-RNO-1799339", "REACTOME:R-SCE-1799339", "REACTOME:R-SPO-1799339" ]

10

[ "1dul", "1ffh", "1hq1", "1j8m", "1j8y", "1jpj", "1jpn", "1ls1", "1mfq", "1ng1", "1o87", "1okk", "1qb2", "1qzw", "1qzx", "1rj9", "1ry1", "1wgw", "2c03", "2c04", "2cnw", "2ffh", "2go5", "2iy3", "2j28", "2j37", "2j45", "2j46", "2j7p", "2jqe", "2ng1", "2pxb"...

82

[ "PUB00028143", "PUB00035998", "PUB00035999", "PUB00053948", "PUB00060577", "PUB00060578", "PUB00063486", "PUB00100261" ]

[ "16469117", "17622352", "17507650", "12364595", "9799502", "10656787", "12605305", "34020957" ]

[ "Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages.", "X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.", "The signal recognition particle (SRP) RNA links conformational changes in the SRP to pro...

[ 2006, 2007, 2007, 2002, 1998, 2000, 2003, 2021 ]

8

[]

[ "IPR004780", "IPR006325" ]

0

2

0

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 939, 24064, 2, 7516, 689 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 22, 1, 1, 2, 1, 11, 6, 1, 12, 4, 1, 1, 29 ]

13

true

Family

Signal recognition particle, SRP54 subunit

SRP54

8

IPR022944

22,944

ATPase, V1 complex, subunit F, bacterial/archaeal

ATPase_V1-cplx_fsu_bac/arc

Family

1,149

false

This entry represents the F subunit of A/V-type ATP synthases from bacteria and archaea. Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a p...

[]

0

[ "HAMAP" ]

[ "MF_00312" ]

[ "ATP_synth_F_arch" ]

[ 1149 ]

1

[]

0

[ "2d00", "2i4r", "2ov6", "2qai", "3a5c", "3a5d", "3aon", "3j0j", "3vr4", "3vr5", "3vr6", "5knb", "5knc", "5knd", "5y5x", "5y5y", "5y5z", "5y60", "6ly8", "6qum", "6r0w", "6r0y", "6r0z", "6r10", "7vai", "7vaj", "7vak", "7val", "7vam", "7van", "7vao", "7vap"...

58

[ "PUB00007886", "PUB00020603", "PUB00020604", "PUB00020608", "PUB00020609", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00160299" ]

[ "11533110", "15473999", "15078220", "15907459", "15629643", "20450191", "18937357", "1385979", "9741106", "9874757" ]

[ "Structure-function relationships of A-, F- and V-ATPases.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "A new view of an old pore.", "A structural model of the vac...

[ 2001, 2004, 2004, 2005, 2005, 2010, 2008, 1992, 1998, 1992 ]

10

[ "IPR008218" ]

[]

1

0

1

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 685, 440, 24 ]

3

[]

0

true

Family

ATPase, V1 complex, subunit F, bacterial/archaeal

ATPase_V1-cplx_fsu_bac/arc

4

IPR022946

22,946

Uncharacterised protein family UPF0313

UPF0313

Family

8,099

false

The proteins in this entry are functionally uncharacterised. They contain a radical SAM domain [ ].

[]

0

[ "HAMAP", "PANTHER", "SFLD", "NCBIFAM" ]

[ "MF_01251", "PTHR32331", "SFLDG01069", "TIGR03904" ]

[ "UPF0313", "", "UPF0313", "SAM_YgiQ" ]

[ 7449, 8099, 7697, 7636 ]

4

[]

0

[]

0

[ "PUB00010539" ]

[ "11222759" ]

[ "Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 154, 7745, 15, 2, 183 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0313

UPF0313

6

IPR022947

22,947

Large ribosomal subunit protein eL18, archaea

Ribosomal_eL18_arc

Family

935

false

This entry represents the large ribosomal subunit protein eL18 from the 50S ribosomal subunit of archaea. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids i...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_00329", "NF003079" ]

[ "Ribosomal_eL18", "PRK04005.1" ]

[ 825, 935 ]

2

[]

0

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp", "1w2b"...

92

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR000039" ]

[]

1

0

1

[ "Archaea", "Geodia barretti", "unclassified sequences" ]

[ 898, 1, 36 ]

3

[]

0

true

Family

Large ribosomal subunit protein eL18, archaea

Ribosomal_eL18_arc

7

IPR022948

22,948

Chitooligosaccharide deacetylase ChbG-like, bacteria

COD_ChbG_bac

Family

2,204

false

This entry represents chitooligosaccharide deacetylase ChbG (YdjC)-like proteins found in bacteria, including carbohydrate deacetylases from Firmicutes and chitooligosaccharide deacetylases from Enterobacteriaceae [ ]. ChbG is involved in the degradation of chitin.

[ "GO:0016811", "GO:0000272" ]

[ "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "polysaccharide catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "CDD" ]

[ "MF_01246", "cd10803" ]

[ "COD", "YdjC_EF3048_like" ]

[ 1689, 2204 ]

2

[ "EC" ]

[ "3.5.1.105" ]

[ "EC:3.5.1.105" ]

1

[ "2i5i", "7vi8" ]

2

[ "PUB00074303" ]

[ "22797760" ]

[ "The chbG gene of the chitobiose (chb) operon of Escherichia coli encodes a chitooligosaccharide deacetylase." ]

[ 2012 ]

1

[ "IPR006879" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta" ]

[ 2202, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Chitooligosaccharide deacetylase ChbG-like, bacteria

COD_ChbG_bac

5

IPR022950

22,950

Homogentisate 1,2-dioxygenase, bacterial

Homogentis_dOase_bac

Family

3,829

false

This entry represents bacterial homogentisate 1,2-dioxygenase . This enzyme mediates the conversion of homogentisate to maleylacetoacetate; a step in the catabolism of both tyrosine and phenylalanine.

[ "GO:0004411", "GO:0006559", "GO:0006572" ]

[ "homogentisate 1,2-dioxygenase activity", "L-phenylalanine catabolic process", "L-tyrosine catabolic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_00334" ]

[ "Homogentis_dioxygen" ]

[ 3829 ]

1

[ "EC" ]

[ "1.13.11.5" ]

[ "EC:1.13.11.5" ]

1

[ "3zds", "4aq2", "4aq6" ]

3

[]

0

[ "IPR005708" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3820, 5, 4 ]

3

[]

0

true

Family

Homogentisate 1,2-dioxygenase, bacterial

Homogentis_dOase_bac

5

IPR022951

22,951

Uncharacterised protein family UPF0309

UPF0309

Family

1,082

false

The proteins in this entry are functionally uncharacterised, but the majority contain a sugar isomerase (SIS) domain, which is a phosphosugar-binding module found in proteins that have a role in phosphosugar isomerisation or regulation.

[]

0

[ "HAMAP" ]

[ "MF_01240" ]

[ "UPF0309" ]

[ 1082 ]

1

[]

0

[ "3cvj", "9eol", "9f7o", "9f7v" ]

4

[]

0

[]

0

null

[ "Bacteria" ]

[ 1082 ]

1

[]

0

true

Family

Uncharacterised protein family UPF0309

UPF0309

3

IPR022952

22,952

Archease, archaea

Archease_arc

Family

370

false

This entry represents the archaeal form of archeases. The archease superfamily of proteins are represented in all three domains of life. Archease genes are generally located adjacent to genes encoding proteins involved in DNA or RNA processing and therefore have been predicted to be modulators or chaperones involved in...

[]

0

[ "HAMAP" ]

[ "MF_01222" ]

[ "Archease_arch" ]

[ 370 ]

1

[]

0

[ "1jw3", "4n2p" ]

2

[ "PUB00020987", "PUB00045441" ]

[ "11854485", "17470432" ]

[ "An NMR approach to structural proteomics.", "Archease from Pyrococcus abyssi improves substrate specificity and solubility of a tRNA m5C methyltransferase." ]

[ 2002, 2007 ]

2

[ "IPR002804" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Odynerus spinipes", "ecological metagenomes" ]

[ 337, 25, 1, 7 ]

4

[]

0

true

Family

Archease, archaea

Archease_arc

5

IPR022953

22,953

ATP-dependent 6-phosphofructokinase

ATP_PFK

Family

44,972

false

The enzyme-catalysed transfer of a phosphoryl group from ATP is an important reaction in a wide variety of biological processes [ ]. One enzyme that utilises this reaction is phosphofructokinase (PFK), which catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate, a key regulatory step in the...

[ "GO:0003872", "GO:0006002", "GO:0006096" ]

[ "6-phosphofructokinase activity", "fructose 6-phosphate metabolic process", "glycolytic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PRINTS" ]

[ "PR00476" ]

[ "PHFRCTKINASE" ]

[ 44972 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1.11", "PWY-1042", "PWY-1861", "PWY-5484", "PWY-7385", "R-BTA-6798695", "R-BTA-70171", "R-CEL-6798695", "R-CEL-70171", "R-DME-6798695", "R-DME-70171", "R-HSA-6798695", "R-HSA-70171", "R-MMU-6798695", "R-MMU-70171", "R-RNO-6798695", "R-RNO-70171", "R-SCE-6798695", "R-SCE-7017...

[ "EC:2.7.1.11", "METACYC:PWY-1042", "METACYC:PWY-1861", "METACYC:PWY-5484", "METACYC:PWY-7385", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-70171", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-70171", "REACTOME:R-DME-6798695", "REACTOME:R-DME-70171", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-70171...

21

[ "1kzh", "1mto", "1pfk", "1zxx", "2f48", "2hig", "2pfk", "3f5m", "3hno", "3k2q", "3o8l", "3o8n", "3o8o", "3opy", "3pfk", "3u39", "4a3s", "4i36", "4i4i", "4i7e", "4omt", "4pfk", "4rh3", "4u1r", "4wl0", "4xyj", "4xyk", "4xz2", "5xoe", "5xz6", "5xz7", "5xz8"...

54

[ "PUB00000020", "PUB00003237", "PUB00004002", "PUB00014238" ]

[ "7825568", "2975709", "2953977", "12023862" ]

[ "Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.", "Crystal structure of the complex of phosphofructokinase from Escherichia coli with its reaction products.", "Mutations in the active site of Escheric...

[ 1995, 1988, 1987, 2002 ]

4

[]

[ "IPR009161", "IPR011183", "IPR011403", "IPR011404", "IPR011405", "IPR012003", "IPR012004" ]

0

7

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 82, 27087, 17114, 3, 686 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 34, 2, 28, 6, 1, 40, 12, 1, 35, 23, 2, 1, 86 ]

13

true

Family

ATP-dependent 6-phosphofructokinase

ATP_PFK

6

IPR022954

22,954

Uncharacterised protein family UPF0148

UPF0148

Family

41

false

The proteins in this entry are functionally uncharacterised. However, they show protein sequence similarity with Sjoegren syndrome/scleroderma autoantigen 1 protein ( ).

[]

0

[ "HAMAP" ]

[ "MF_00343" ]

[ "UPF0148" ]

[ 41 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 41 ]

1

[]

0

true

Family

Uncharacterised protein family UPF0148

UPF0148

3

IPR022955

22,955

GMP synthase

GMP_synthase

Family

26,475

false

GMP synthase or glutamine amidotransferase catalyzes the synthesis of GMP from xantosine monophosphate.

[ "GO:0003922", "GO:0006177" ]

[ "GMP synthase (glutamine-hydrolyzing) activity", "GMP biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_00344" ]

[ "GMP_synthase" ]

[ 26475 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.5.2", "PWY-7221", "R-PFA-73817", "R-PFA-9748787", "R-SCE-73817", "R-SCE-9748787", "R-SPO-73817", "R-SPO-9748787" ]

[ "EC:6.3.5.2", "METACYC:PWY-7221", "REACTOME:R-PFA-73817", "REACTOME:R-PFA-9748787", "REACTOME:R-SCE-73817", "REACTOME:R-SCE-9748787", "REACTOME:R-SPO-73817", "REACTOME:R-SPO-9748787" ]

8

[ "1gpm", "2ywb", "2ywc", "3tqi", "3uow", "4wim", "4wio", "5tw7", "7mo6", "7sbc", "7zu9" ]

11

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 120, 23691, 2287, 4, 373 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 5, 1, 1, 3, 1, 1, 2 ]

7

true

Family

GMP synthase

GMP_synthase

6

IPR022956

22,956

Beta-hexosaminidase, bacterial

Beta_hexosaminidase_bac

Family

5,807

false

This entry represents bacterial beta-hexosaminidases that are involved in cell wall biogenesis and peptidoglycan recycling [ ].

[ "GO:0004563" ]

[ "beta-N-acetylhexosaminidase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00364" ]

[ "NagZ" ]

[ 5807 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.1.52", "PWY-6902", "PWY-7822", "PWY-7883" ]

[ "EC:3.2.1.52", "METACYC:PWY-6902", "METACYC:PWY-7822", "METACYC:PWY-7883" ]

4

[ "1tr9", "1y65", "2oxn", "3gs6", "3gsm", "4g6c", "4gnv", "4gvf", "4gvg", "4gvh", "4gvi", "4hzm", "4mss", "5g1m", "5g2m", "5g3r", "5g5k", "5g5u", "5g6t", "5ly7", "5utp", "5utq", "5utr", "6dte", "6jti", "6jtj", "6jtk", "6jtl" ]

28

[ "PUB00054020" ]

[ "10940025" ]

[ "Molecular characterization of the beta-N-acetylglucosaminidase of Escherichia coli and its role in cell wall recycling." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5748, 6, 53 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Beta-hexosaminidase, bacterial

Beta_hexosaminidase_bac

7

IPR022957

22,957

Uncharacterised protein family UPF0299

Uncharacterised_UPF0299

Family

1,254

false

This family, UPF0299, is represented by YohJ, an inner membrane protein with four predicted transmembrane domains; the C terminus is located in the periplasm [ ]. The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP" ]

[ "MF_01144" ]

[ "UPF0299" ]

[ 1254 ]

1

[]

0

[]

0

[ "PUB00042652" ]

[ "15919996" ]

[ "Global topology analysis of the Escherichia coli inner membrane proteome." ]

[ 2005 ]

1

[ "IPR005538" ]

[]

1

0

1

[ "Bacteria", "Timema californicum" ]

[ 1253, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0299

Uncharacterised_UPF0299

5

IPR022958

22,958

Uncharacterised protein family UPF0294

UPF0294

Family

1,059

false

The proteins in this entry are functionally uncharacterised, but contain a single endonuclease/exonuclease/phosphatase domain. The family is represented by YafD, which has been reported to be similar to YadD, YjiP, YjiQ and YhgA, [ ], though these are not found in this entry.

[]

0

[ "HAMAP" ]

[ "MF_01119" ]

[ "UPF0294" ]

[ 1059 ]

1

[]

0

[]

0

[ "PUB00034642" ]

[ "8837478" ]

[ "Characterization and sequence of the Escherichia coli panBCD gene cluster." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 1058, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0294

UPF0294

2

IPR022960

22,960

Glycine-tRNA ligase, archaeal

Gly_tRNA_ligase_arc

Family

127

false

This entry represents archaeal glycine-tRNA ligases (also known as glycyl-tRNA synthetases). In eubacteria, glycine-tRNA ligase ( ) is an alpha2/beta2 tetramer composed of 2 different subunits [ , , ]. In some eubacteria, in archaea and eukaryotes, glycine-tRNA ligase is an alpha2 dimer, this family. It belongs to clas...

[ "GO:0004820" ]

[ "glycine-tRNA ligase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00253_A" ]

[ "Gly_tRNA_synth_A" ]

[ 127 ]

1

[ "EC" ]

[ "6.1.1.14" ]

[ "EC:6.1.1.14" ]

1

[]

0

[ "PUB00000386", "PUB00000723", "PUB00002277", "PUB00002392", "PUB00002880", "PUB00004391", "PUB00005365", "PUB00006333", "PUB00006477", "PUB00006561", "PUB00007191", "PUB00007363", "PUB00079872", "PUB00079873" ]

[ "8364025", "8274143", "7665503", "6309809", "7962006", "1852601", "2053131", "7556056", "10673435", "10064708", "2203971", "10447505", "10704480", "12458790" ]

[ "Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.", "The aminoacyl-tRNA synthetase family: modules at work.", "The glycyl-tRNA synthetase of Chlamydia trachomatis.", "Primary structures of both subunits of Escherichia coli glycyl-tRNA synthetase.", "Human glyc...

[ 1993, 1993, 1995, 1983, 1994, 1991, 1991, 1995, 2000, 1999, 1990, 1999, 2000, 2002 ]

14

[ "IPR002315" ]

[]

1

0

1

[ "Archaea" ]

[ 127 ]

1

[]

0

true

Family

Glycine-tRNA ligase, archaeal

Gly_tRNA_ligase_arc

3

IPR022961

22,961

Glycine-tRNA ligase, bacterial

Gly_tRNA_ligase_bac

Family

10,444

false

This entry represents bacterial Glycine-tRNA ligases (also known as Glycyl-tRNA synthetase). In eubacteria, glycine-tRNA ligase ( ) is an alpha2/beta2 tetramer composed of 2 different subunits [ , , ]. In some eubacteria, in archaea and eukaryotes, glycine-tRNA ligase is an alpha2 dimer, this family. It belongs to clas...

[ "GO:0004820" ]

[ "glycine-tRNA ligase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00253_B" ]

[ "Gly_tRNA_synth_B" ]

[ 10444 ]

1

[ "EC" ]

[ "6.1.1.14" ]

[ "EC:6.1.1.14" ]

1

[ "1ati", "8sld", "8slf", "8slg", "8slh", "8t5n", "8u2p", "8u2q" ]

8

[ "PUB00000386", "PUB00000723", "PUB00002277", "PUB00002392", "PUB00002880", "PUB00004391", "PUB00005365", "PUB00006333", "PUB00006477", "PUB00006561", "PUB00007191", "PUB00007363", "PUB00079872", "PUB00079873" ]

[ "8364025", "8274143", "7665503", "6309809", "7962006", "1852601", "2053131", "7556056", "10673435", "10064708", "2203971", "10447505", "10704480", "12458790" ]

[ "Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.", "The aminoacyl-tRNA synthetase family: modules at work.", "The glycyl-tRNA synthetase of Chlamydia trachomatis.", "Primary structures of both subunits of Escherichia coli glycyl-tRNA synthetase.", "Human glyc...

[ 1993, 1993, 1995, 1983, 1994, 1991, 1991, 1995, 2000, 1999, 1990, 1999, 2000, 2002 ]

14

[ "IPR002315" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ct3es5", "unclassified sequences" ]

[ 10135, 94, 1, 214 ]

4

[]

0

true

Family

Glycine-tRNA ligase, bacterial

Gly_tRNA_ligase_bac

1

IPR022962

22,962

Soluble pyridine nucleotide transhydrogenase, gammaproteobacteria

STH_gammaproteobact

Family

2,818

false

This entry represents soluble pyridine nucleotide transhydrogenases mainly found in gammaproteobacteria. Its physiological role is the conversion of NADPH generated by peripheral catabolic pathways to NADH, which can be oxidized for energy generation, maintaining the homeostasis of these two redox cofactors [ , , ].

[ "GO:0003957" ]

[ "NAD(P)+ transhydrogenase (Si-specific) activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00247" ]

[ "SthA" ]

[ 2818 ]

1

[ "EC" ]

[ "1.6.1.1" ]

[ "EC:1.6.1.1" ]

1

[ "9n4y" ]

1

[ "PUB00053952", "PUB00150987", "PUB00150988" ]

[ "6840064", "21545646", "16599556" ]

[ "Why are two different types of pyridine nucleotide transhydrogenase found in living organisms?", "Overexpression and biochemical characterization of soluble pyridine nucleotide transhydrogenase from Escherichia coli.", "Effect of overexpression of a soluble pyridine nucleotide transhydrogenase (UdhA) on the pr...

[ 1983, 2011, 2006 ]

3

[ "IPR001100" ]

[]

1

0

1

[ "Bacteria", "Timema californicum", "unclassified sequences" ]

[ 2810, 1, 7 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Soluble pyridine nucleotide transhydrogenase, gammaproteobacteria

STH_gammaproteobact

2

IPR022963

22,963

Galactokinase, bacterial

Galactokinase_bac

Family

7,804

false

Galactokinase catalyses the first reaction in the galactose metabolism pathway, the ATP-dependent phosphorylation of galactose, yielding galactose-1-phosphate [ , ]. Deficiency in this enzyme results in the disease galactosemia, which is responsible for the formation of cataracts in newborn babies, and is possibly resp...

[ "GO:0004335", "GO:0006012" ]

[ "galactokinase activity", "galactose metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_00246" ]

[ "Galactokinase" ]

[ 7804 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.6", "PWY-3821", "PWY-6317", "PWY-6527" ]

[ "EC:2.7.1.6", "METACYC:PWY-3821", "METACYC:PWY-6317", "METACYC:PWY-6527" ]

4

[ "1pie", "1s4e", "2cz9", "2dei", "2dej" ]

5

[ "PUB00003653", "PUB00004765" ]

[ "3062381", "1438294" ]

[ "Yeast regulatory gene GAL3: carbon regulation; UASGal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases.", "Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast." ]

[ 1988, 1992 ]

2

[ "IPR000705" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 17, 7769, 3, 15 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Galactokinase, bacterial

Galactokinase_bac

9

IPR022964

22,964

Translation initiation factor 2, alpha subunit, archaeal

TIF2_asu_arc

Family

258

false

Archaeal transcription initiation factor 2 is, like its eukaryotic homologue, a heterotrimeric protein with alpha, beta and gamma subunits [ ]. It is thought play an essential role in the recognition of the correct codon for the start of translation, similar to the role of eukaryotic transcription initiation factor. Th...

[]

0

[ "HAMAP" ]

[ "MF_00231" ]

[ "eIF_2_alpha" ]

[ 258 ]

1

[]

0

[ "1yz6", "2aho", "3aev", "3cw2", "3v11", "5jb3", "5jbh", "6swc" ]

8

[ "PUB00017012", "PUB00017013" ]

[ "11980477", "11416183" ]

[ "Structure of the beta subunit of translation initiation factor 2 from the archaeon Methanococcus jannaschii: a representative of the eIF2beta/eIF5 family of proteins.", "Molecular mechanisms of translation initiation in eukaryotes." ]

[ 2002, 2001 ]

2

[ "IPR011488" ]

[]

1

0

1

[ "Archaea", "bioreactor metagenome" ]

[ 257, 1 ]

2

[]

0

true

Family

Translation initiation factor 2, alpha subunit, archaeal

TIF2_asu_arc

4

IPR022965

22,965

ATP-dependent DNA helicase Hel308

Helicase_Hel308

Family

1,034

false

This entry represents ATP-dependent DNA helicase Hel308 from Archaea. It is thought to be implicated in remodelling compromised replication forks [ , , ].

[ "GO:0004386" ]

[ "helicase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00442" ]

[ "Helicase_Hel308" ]

[ 1034 ]

1

[ "EC" ]

[ "5.6.2.4" ]

[ "EC:5.6.2.4" ]

1

[ "2p6r", "2p6u", "2va8", "2zj2", "2zj5", "2zj8", "2zja", "9b15" ]

8

[ "PUB00074105", "PUB00074106", "PUB00074107" ]

[ "19143605", "15994460", "17991488" ]

[ "Molecular biology of Hel308 helicase in archaea.", "Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands.", "Archaeal Hel308 domain V couples DNA binding to ATP hydrolysis and positions DNA for unwinding over the helicase ratchet." ]

[ 2009, 2005, 2007 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "ecological metagenomes" ]

[ 1014, 5, 1, 14 ]

4

[]

0

true

Family

ATP-dependent DNA helicase Hel308

Helicase_Hel308

5

IPR022966

22,966

Ribonuclease II/R, conserved site

RNase_II/R_CS

Conserved_site

31,012

false

This entry represents a conserved site for the ribonuclease II family. Proteins with this signature include characterised and related sequences to exoribonuclease II (RNase II) [ ] and ribonuclease R, a bacterial 3' --> 5' exoribonuclease homologous to RNase II [ , , ].

[]

0

[ "PROSITE" ]

[ "PS01175" ]

[ "RIBONUCLEASE_II" ]

[ 31012 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.1.13.1", "R-CEL-429958", "R-CEL-450385", "R-CEL-450513", "R-CEL-9930044", "R-HSA-1368108", "R-HSA-1989781", "R-HSA-2151201", "R-HSA-2426168", "R-HSA-380994", "R-HSA-381340", "R-HSA-400206", "R-HSA-429958", "R-HSA-450385", "R-HSA-450513", "R-HSA-450604", "R-HSA-6791226", "R-HSA-9...

[ "EC:3.1.13.1", "REACTOME:R-CEL-429958", "REACTOME:R-CEL-450385", "REACTOME:R-CEL-450513", "REACTOME:R-CEL-9930044", "REACTOME:R-HSA-1368108", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-2426168", "REACTOME:R-HSA-380994", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-400206",...

33

[ "2id0", "2ix0", "2ix1", "2vnu", "2wp8", "4ifd", "4pmw", "4ro1", "5c0w", "5c0x", "5g06", "5jea", "5k36", "5vzj", "5xgu", "6d6q", "6d6r", "6fsz", "6h25", "6lqs", "7ajt", "7aju", "7am1", "7d4i", "7dcy", "7dic", "7did", "7dol", "7tuv", "8cdu", "8cdv", "8cec"...

44

[ "PUB00015537", "PUB00017190", "PUB00017191", "PUB00045119" ]

[ "11948193", "15604703", "9829834", "16806266" ]

[ "Purification and characterization of the Escherichia coli exoribonuclease RNase R. Comparison with RNase II.", "Ribosomal RNA processing and an RNase R family member in chloroplasts of Arabidopsis.", "The yeast nuclear gene DSS1, which codes for a putative RNase II, is necessary for the function of the mitocho...

[ 2002, 2004, 1998, 2006 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "unclassified sequences" ]

[ 20669, 10070, 29, 4, 240 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 10, 2, 5, 7, 2, 10, 4, 2, 7, 13, 3, 2, 11 ]

13

true

Conserved_site

Ribonuclease II/R, conserved site

RNase_II/R_CS

8

IPR022968

22,968

16S/18S rRNA aminocarboxypropyltransferase Tsr3

Tsr3-like

Family

5,339

false

This entry represents18S rRNA aminocarboxypropyltransferases Tsr3 and its homologues. Tsr3 from fungi and animals are responsible for 18S rRNA hypermodification. It introduces the acp group to the hypermodified m1acp3psi nucleotide at position 1191 (yeast)/ 1248 (humans) of 18S rRNA. The crystal structure of archaeal T...

[ "GO:0016740", "GO:0106388", "GO:0006364" ]

[ "transferase activity", "rRNA small subunit aminocarboxypropyltransferase activity", "rRNA processing" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "PANTHER" ]

[ "MF_01116", "PTHR20426" ]

[ "TSR3", "" ]

[ 4800, 5283 ]

2

[ "EC", "METACYC", "REACTOME" ]

[ "2.5.1.157", "PWY-8341", "R-HSA-6790901" ]

[ "EC:2.5.1.157", "METACYC:PWY-8341", "REACTOME:R-HSA-6790901" ]

3

[ "5ap8", "5apg" ]

2

[ "PUB00094251" ]

[ "27084949" ]

[ "Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans." ]

[ 2016 ]

1

[]

0

null

[ "Archaea", "Eukaryota", "unclassified sequences" ]

[ 773, 4533, 33 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 1, 11, 1, 4, 4, 1, 1, 6 ]

12

true

Family

16S/18S rRNA aminocarboxypropyltransferase Tsr3

Tsr3-like

6

IPR022969

22,969

Chloride channel YfeO

Chloride_channel_YfeO

Family

1,047

false

Chloride channels (CLCs) constitute an evolutionarily well-conserved family of voltage-gated channels that are structurally unrelated to the other known voltage-gated channels. They are found in organisms ranging from bacteria to yeasts and plants, and also to animals. Their functions in higher animals likely include t...

[]

0

[ "HAMAP" ]

[ "MF_01115" ]

[ "CLC_YfeO" ]

[ 1047 ]

1

[]

0

[]

0

[ "PUB00000734", "PUB00001999", "PUB00004085", "PUB00004230", "PUB00004913", "PUB00155406" ]

[ "9046241", "7581380", "2174129", "8559248", "9207144", "29845874" ]

[ "Chloride channels: an emerging molecular picture.", "Myotonia levior is a chloride channel disorder.", "Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.", "A common molecular basis for three inherited kidney stone diseases.", "Transmembrane topology...

[ 1997, 1995, 1990, 1996, 1997, 2018 ]

6

[ "IPR001807" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 1047 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Chloride channel YfeO

Chloride_channel_YfeO

5

IPR022970

22,970

Nucleoside triphosphate hydrolase-related

NTP_hydrolase-rel

Family

374

false

The archaeal proteins in this entry are functionally uncharacterised, but belong to the P-loop containing nucleoside triphosphate hydrolases superfamily. Sequence analysis suggests that they may be archaeal dephospho-CoA kinase homologues.

[]

0

[ "HAMAP" ]

[ "MF_01111" ]

[ "UPF0200" ]

[ 374 ]

1

[]

0

[ "3h0k", "3lw7" ]

2

[]

0

[]

0

null

[ "Archaea", "hydrocarbon metagenome" ]

[ 373, 1 ]

2

[]

0

true

Family

Nucleoside triphosphate hydrolase-related

NTP_hydrolase-rel

7

IPR022971

22,971

5'-deoxynucleotidase YfbR

YfbR

Family

1,767

false

This entry contains Escherichia coli (strain K12) YfbR. It is a 5'-deoxynucleotidase that functions as a dCMP phosphohydrolase in a salvage pathway for the synthesis of dUMP in a dcd/deoA mutant [ ]. YfbR contains a conserved HD domain [ ]. YfbR has phosphatase activity with deoxyribonucleoside 5'-monophosphates and do...

[]

0

[ "HAMAP" ]

[ "MF_01100" ]

[ "5DNU" ]

[ 1767 ]

1

[ "EC" ]

[ "3.1.3.89" ]

[ "EC:3.1.3.89" ]

1

[ "2paq", "2par", "2pau" ]

3

[ "PUB00034504", "PUB00048646", "PUB00053777", "PUB00053957", "PUB00097959" ]

[ "15489502", "18353368", "15808744", "17827303", "33926954" ]

[ "General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG.", "Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli....

[ 2004, 2008, 2005, 2007, 2021 ]

5

[ "IPR039356" ]

[]

1

0

1

[ "Bacteria", "Beauveria bassiana D1-5", "unclassified sequences" ]

[ 1764, 1, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

5'-deoxynucleotidase YfbR

YfbR

6

IPR022972

22,972

Uncharacterised protein family UPF0292

UPF0292

Family

173

false

The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP" ]

[ "MF_01095" ]

[ "UPF0292" ]

[ 173 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriati", "ecological metagenomes" ]

[ 171, 2 ]

2

[]

0

true

Family

Uncharacterised protein family UPF0292

UPF0292

6

IPR022973

22,973

Large ribosomal subunit protein uL10, bacteria

Ribosomal_uL10_bact

Family

24,945

false

This entry represents the large ribosomal subunit protein uL10 family found mainly in bacteria and in plant chloroplast. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation o...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_00362", "NF000955" ]

[ "Ribosomal_uL10", "PRK00099.1-1" ]

[ 23735, 24937 ]

2

[]

0

[ "1zav", "1zaw", "1zax", "3j7z", "3j9w", "3j9y", "3j9z", "3ja1", "3jcj", "4uy8", "4v63", "4v6f", "4v6n", "4v6o", "4v6p", "4v6q", "4v6r", "4v6s", "4v6v", "4v7b", "4v7c", "4v7d", "4v7j", "4v7k", "4v7p", "4v85", "4v89", "4v9o", "4v9p", "4w2e", "4wpo", "4wqf"...

311

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR047865" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 23785, 718, 2, 440 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 1, 3, 4 ]

4

true

Family

Large ribosomal subunit protein uL10, bacteria

Ribosomal_uL10_bact

9

IPR022975

22,975

Pyrimidine-specific ribonucleoside hydrolase RihA

Pyrim_hydro_RihA

Family

1,075

false

The rihA gene encodes a ribonucleoside hydrolase that preferentially utilises cytidine and uridine [ ]. The k cat /K M for uridine is approximately 10 times higher than for cytidine, largely due to a lower K M value for uridine [ ]. There are two other nucleoside hydrolases with differing specificities encoded by the r...

[ "GO:0045437", "GO:0006206", "GO:0015949" ]

[ "uridine nucleosidase activity", "pyrimidine nucleobase metabolic process", "nucleobase-containing small molecule interconversion" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_01431" ]

[ "Pyrim_hydro_RihA" ]

[ 1075 ]

1

[]

0

[ "1yoe", "3g5i", "4wr2" ]

3

[ "PUB00053958", "PUB00053959" ]

[ "11027694", "16411753" ]

[ "The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation.", "New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product." ]

[ 2001, 2006 ]

2

[ "IPR023186" ]

[]

1

0

1

[ "Bacteria", "Nematoda" ]

[ 1073, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Pyrimidine-specific ribonucleoside hydrolase RihA

Pyrim_hydro_RihA

4

IPR022976

22,976

Non-specific ribonucleoside hydrolase RihC

Nucleosid_hydro_RihC_nonspecif

Family

875

false

This entry represents the RihC proteins, which are ribonucleoside hydrolases with a broad substrate specificity. RihC has decreasing activity in the order uridine >xanthosine >inosine >adenosine >cytidine >guanosine [ ]. There are two other ribonucleoside hydrolases present in Escherichia coli encoded by the rihA and r...

[ "GO:0016798" ]

[ "hydrolase activity, acting on glycosyl bonds" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_01432" ]

[ "Nucleosid_hydro_RihC" ]

[ 875 ]

1

[]

0

[]

0

[ "PUB00053958" ]

[ "11027694" ]

[ "The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation." ]

[ 2001 ]

1

[ "IPR023186" ]

[]

1

0

1

[ "Enterobacteriaceae" ]

[ 875 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Non-specific ribonucleoside hydrolase RihC

Nucleosid_hydro_RihC_nonspecif

9

IPR022977

22,977

Pyrimidine-specific ribonucleoside hydrolase RihB

Pyrim_hydro_RihB

Family

128

false

This entry represents the RihB ribonucleoside hydrolases, which are homologous to the RihA and RihC hydrolases. RihB hydrolyses cytidine and uridine to ribose and cytosine or uracil respectively; however in contrast to RihA, RihB displays a preference for cytidine [ ].

[ "GO:0050263", "GO:0046133" ]

[ "ribosylpyrimidine nucleosidase activity", "pyrimidine ribonucleoside catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_01433" ]

[ "Pyrim_hydro_RihB" ]

[ 128 ]

1

[ "EC" ]

[ "3.2.2.8" ]

[ "EC:3.2.2.8" ]

1

[ "1q8f", "3b9x", "3mkm", "3mkn" ]

4

[ "PUB00053958" ]

[ "11027694" ]

[ "The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation." ]

[ 2001 ]

1

[ "IPR023186" ]

[]

1

0

1

[ "Enterobacteriaceae" ]

[ 128 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Pyrimidine-specific ribonucleoside hydrolase RihB

Pyrim_hydro_RihB

9

IPR022978

22,978

Monofunctional glycosyl transferase

Monofunct_glyco_trans

Family

117

false

Proteins in this family are thought to be involved in cell wall peptidoglycan biosynthesis. In particular they are thought to be responsible for the elongation of the glycan strands using lipid-linked disaccharide-pentapeptide as the substrate [ ].

[ "GO:0016757" ]

[ "glycosyltransferase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_01434" ]

[ "MGT" ]

[ 117 ]

1

[ "EC" ]

[ "2.4.99.28" ]

[ "EC:2.4.99.28" ]

1

[]

0

[ "PUB00054012" ]

[ "11466281" ]

[ "Identification and characterization of a monofunctional glycosyltransferase from Staphylococcus aureus." ]

[ 2001 ]

1

[]

0

null

[ "Staphylococcus", "human gut metagenome" ]

[ 116, 1 ]

2

[]

0

true

Family

Monofunctional glycosyl transferase

Monofunct_glyco_trans

8

IPR022980

22,980

Photosystem I, reaction centre subunit XI

PSI_suXI

Family

1,749

false

The trimeric photosystem I of the cyanobacterium Synechococcus elongatus recomprises 11 protein subunits. Subunit XI, PsaL, from plants and bacteria is one of the smaller subunits with only two transmembrane α helices. PsaL interacts closely with PsaI [ ].

[]

0

[ "HAMAP", "PANTHER" ]

[ "MF_00447", "PTHR34803" ]

[ "PSI_PsaL", "" ]

[ 831, 1748 ]

2

[]

0

[ "1jb0", "2o01", "2wsc", "2wse", "2wsf", "3lw5", "3pcq", "4fe1", "4l6v", "4rku", "4xk8", "4y28", "5l8r", "5oy0", "5zf0", "5zgb", "5zgh", "5zji", "6fos", "6hqb", "6igz", "6ijj", "6ijo", "6jeo", "6jo5", "6jo6", "6k33", "6k61", "6kif", "6kig", "6kmw", "6kmx"...

137

[ "PUB00008234" ]

[ "8901876" ]

[ "Photosystem I at 4 A resolution represents the first structural model of a joint photosynthetic reaction centre and core antenna system." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 533, 1216 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 3, 10 ]

3

true

Family

Photosystem I, reaction centre subunit XI

PSI_suXI

1

IPR022981

22,981

Large ribosomal subunit protein uL16, archaea

Ribosomal_uL16_arc

Family

801

false

This family consists of archaeal large ribosomal subunit protein uL16 (L10). Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide c...

[]

0

[ "HAMAP" ]

[ "MF_00448" ]

[ "Ribosomal_uL16_arch" ]

[ 801 ]

1

[]

0

[ "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp", "1yhq", "1yi2", "1yij", "1yit", "1yj9", "1yjn", "1yjw", "2otj", "2otl", "2qa4", "2qex", "3cc2", "3cc4", "3cc7", "3cce", "3ccj", "3ccl", "3ccm", "3ccq"...

71

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR001197" ]

[]

1

0

1

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 780, 9, 12 ]

3

[]

0

true

Family

Large ribosomal subunit protein uL16, archaea

Ribosomal_uL16_arc

9

IPR022982

22,982

DNA double-strand break repair Rad50 ATPase, archaeal type

Rad50_ATPase_archaeal

Family

616

false

Rad50 is involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site [ ...

[]

0

[ "HAMAP" ]

[ "MF_00449" ]

[ "RAD50" ]

[ 616 ]

1

[]

0

[]

0

[ "PUB00026038" ]

[ "11371344" ]

[ "Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase." ]

[ 2001 ]

1

[]

0

null

[ "Aquificia", "Archaea", "bioreactor metagenome" ]

[ 14, 601, 1 ]

3

[]

0

true

Family

DNA double-strand break repair Rad50 ATPase, archaeal type

Rad50_ATPase_archaeal

5

IPR022983

22,983

M18 family aminopeptidase 1, putative

M18_aminopeptidase_1

Family

33

false

This group of metallopeptidases belong to the MEROPS peptidase family M18, (clan MH). The proteins have two catalytic zinc ions at the active site, bound by His/Asp, Asp, Glu, Asp/Glu and His. The catalysed reaction involves the release of an N-terminal aminoacid, usually neutral or hydrophobic, from a polypeptide [ ]....

[ "GO:0004177" ]

[ "aminopeptidase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00466" ]

[ "Aminopeptidase_M18_1" ]

[ 33 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.4.11.-", "PWY-6423", "PWY-7694", "PWY-7954" ]

[ "EC:3.4.11.-", "METACYC:PWY-6423", "METACYC:PWY-7694", "METACYC:PWY-7954" ]

4

[ "1y7e", "2glf", "2glj" ]

3

[ "PUB00003579" ]

[ "7674922" ]

[ "Evolutionary families of metallopeptidases." ]

[ 1995 ]

1

[ "IPR001948" ]

[]

1

0

1

[ "Bacteria" ]

[ 33 ]

1

[]

0

true

Family

M18 family aminopeptidase 1, putative

M18_aminopeptidase_1

1

IPR022984

22,984

M18 family aminopeptidase 2, putative

M18_aminopeptidase_2

Family

2,345

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0004177" ]

[ "aminopeptidase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00467" ]

[ "Aminopeptidase_M18_2" ]

[ 2345 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.4.11.-", "PWY-6423", "PWY-7694", "PWY-7954" ]

[ "EC:3.4.11.-", "METACYC:PWY-6423", "METACYC:PWY-7694", "METACYC:PWY-7954" ]

4

[ "2ijz", "3wt4", "4njq", "4njr", "4oid", "4oiw" ]

6

[ "PUB00003579" ]

[ "7674922" ]

[ "Evolutionary families of metallopeptidases." ]

[ 1995 ]

1

[ "IPR001948" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "freshwater metagenome" ]

[ 2342, 2, 1 ]

3

[]

0

true

Family

M18 family aminopeptidase 2, putative

M18_aminopeptidase_2

3

IPR022985

22,985

Sulfate transporter CysZ

Sulfate_CysZ

Family

4,041

false

CysZ is a high affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake [ ].

[ "GO:0015116", "GO:0000103", "GO:0005886" ]

[ "sulfate transmembrane transporter activity", "sulfate assimilation", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_00468", "NF003433" ]

[ "CysZ", "PRK04949.1" ]

[ 3620, 4040 ]

2

[]

0

[ "3tx3", "6d79", "6d9z" ]

3

[ "PUB00074289" ]

[ "24657232" ]

[ "The Escherichia coli CysZ is a pH dependent sulfate transporter that can be inhibited by sulfite." ]

[ 2014 ]

1

[ "IPR050480" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4003, 5, 33 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Sulfate transporter CysZ

Sulfate_CysZ

4

IPR022986

22,986

Uncharacterised protein family UPF0237, ACT-type

UPF0237_ACT

Family

3,500

false

The proteins in this entry are functionally uncharacterised. They contain an ACT domain; ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. The ACT domain is found in a variety of contexts and is proposed to be a conserved regulatory binding fold [ ].

[]

0

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_01054", "NF001220", "cd04872" ]

[ "UPF0237", "PRK00194.1", "ACT_1ZPV" ]

[ 3272, 3500, 3248 ]

3

[]

0

[ "1zpv" ]

1

[ "PUB00066777" ]

[ "16987805" ]

[ "The ACT domain: a small molecule binding domain and its role as a common regulatory element." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Paralvinella palmiformis", "metagenomes" ]

[ 215, 3254, 1, 30 ]

4

[]

0

true

Family

Uncharacterised protein family UPF0237, ACT-type

UPF0237_ACT

2

IPR022987

22,987

Uncharacterised protein family UPF0227

UPF0227

Family

1,502

false

The proteins in this entry, which include the Escherichia coli (strain K12) protein YcfP, are functionally uncharacterised.

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01047", "NF003431" ]

[ "UPF0227", "PRK04940.1" ]

[ 1383, 1501 ]

2

[]

0

[]

0

[]

0

[ "IPR008886" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 1498, 4 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0227

UPF0227

7

IPR022990

22,990

Ribosome rescue factor SmrB

SmrB-like

Family

2,275

false

This entry represents the Ribosome rescue factor SmrB from Escherichia coli and related proteins mainly from gammaproteobacteria. SmrB acts as a ribosome collision sensor [ ]. It detects stalled/collided disomes (pairs of ribosomes where the leading ribosome is stalled and a second ribosome has collided with it) and cl...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01042", "NF003432" ]

[ "SmrB", "PRK04946.1" ]

[ 2181, 2275 ]

2

[]

0

[ "7qgn", "7qgr" ]

2

[ "PUB00155447" ]

[ "35264790" ]

[ "Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 2269, 3, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ribosome rescue factor SmrB

SmrB-like

6

IPR022991

22,991

Large ribosomal subunit protein eL30, conserved site

Ribosomal_eL30_CS

Conserved_site

6,222

false

A number of eukaryotic, bacterial and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. This entry represents two conserved sites found in large ribosomal subunit protein eL30 family of proteins, which consists of: Mammalian eL30 [ , ]. Leishmania major L30. Yeast eL30 (also known...

[]

0

[ "PROSITE", "PROSITE" ]

[ "PS00709", "PS00993" ]

[ "RIBOSOMAL_L30E_1", "RIBOSOMAL_L30E_2" ]

[ 5348, 5361 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-975956", "R-DDI-975957", "R-GGA-1799339", "R-GGA-72689", "R-GGA-72706", "R-GGA-975956", "R-GGA-97595...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-1799339", "REACTOME:R-DDI-72689", "REACTOME:R-DDI-72706", "REACTOME:R-DDI-9759...

57

[ "1ck2", "1cn7", "1go0", "1go1", "1h7m", "1nmu", "1t0k", "1w3e", "1w40", "1w41", "1w42", "1ysh", "2bo1", "3cpq", "3j6x", "3j6y", "3j77", "3j78", "3j79", "3j7o", "3j7p", "3j7q", "3j7r", "3j92", "3jag", "3jah", "3jai", "3jaj", "3jan", "3jbn", "3jbo", "3jbp"...

581

[ "PUB00001749", "PUB00002444", "PUB00003405", "PUB00004357", "PUB00004394", "PUB00007068", "PUB00007069", "PUB00007070", "PUB00058488", "PUB00059102", "PUB00101554" ]

[ "3840111", "3316213", "2475640", "2501756", "1840672", "11297922", "11290319", "11114498", "22355167", "22096102", "32669547" ]

[ "Molecular cloning and nucleotide sequences of cDNAs specific for rat liver ribosomal proteins S17 and L30.", "The yeast ribosomal protein L32 and its gene.", "Organization and nucleotide sequence of a transcriptional unit of Methanococcus vannielii comprising genes for protein synthesis elongation factors and ...

[ 1985, 1987, 1989, 1989, 1991, 2001, 2001, 2000, 2012, 2011, 2020 ]

11

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 354, 72, 5786, 10 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 2, 1, 3, 5, 5, 1, 6, 5, 1, 2, 14 ]

12

true

Conserved_site

Large ribosomal subunit protein eL30, conserved site

Ribosomal_eL30_CS

3

IPR022992

22,992

Uncharacterised protein family UPF0213, GIY-YIG endonuclease

UPF0213_GIY-YIG_endonuc

Family

1,019

false

The proteins in this entry are functionally uncharacterised but belong to the GIY-YIG endonuclease superfamily.

[]

0

[ "HAMAP" ]

[ "MF_01029" ]

[ "UPF0213" ]

[ 1019 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 1019 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0213, GIY-YIG endonuclease

UPF0213_GIY-YIG_endonuc

5

IPR022996

22,996

Uncharacterised protein family UPF0310

UPF0310

Family

1,324

false

The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP" ]

[ "MF_00771" ]

[ "UPF0310" ]

[ 1324 ]

1

[]

0

[ "1wmm", "2hd9", "2p5d", "2zbn" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 97, 1204, 20, 3 ]

4

[]

0

true

Family

Uncharacterised protein family UPF0310

UPF0310

3

IPR022997

22,997

NADH-quinone oxidoreductase chain 4

NADH_Q_OxRdtase_chain4

Family

13,049

false

This entry represents the chain 4 of NAD(P)H-quinone oxidoreductase from plants and cyanobacteria.

[ "GO:0016655" ]

[ "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00491" ]

[ "NDH1_NuoM" ]

[ 13049 ]

1

[ "EC" ]

[ "7.1.1.-" ]

[ "EC:7.1.1.-" ]

1

[ "6hum", "6khi", "6khj", "6l7o", "6l7p", "6nbq", "6nbx", "6nby", "7eu3", "7f9o", "7wff", "7wg5", "9grx" ]

13

[ "PUB00005074", "PUB00043561", "PUB00045437" ]

[ "1470679", "10940377", "18394423" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I)." ]

[ 1992, 2000, 2008 ]

3

[ "IPR010227" ]

[]

1

0

1

[ "Cyanobacteriota", "Eukaryota" ]

[ 823, 12226 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 2 ]

3

true

Family

NADH-quinone oxidoreductase chain 4

NADH_Q_OxRdtase_chain4

8

IPR022998

22,998

Thiamine phosphate synthase/TenI

ThiamineP_synth_TenI

Domain

37,359

false

Thiamine phosphate synthase (TPS) catalyses the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate in the thiamine biosynthesis pathway [ ]. TenI, a protein from Bacillus subtilis that regulates ...

[]

0

[ "PFAM", "CDD" ]

[ "PF02581", "cd00564" ]

[ "TMP-TENI", "TMP_TenI" ]

[ 37277, 36776 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.5.1.3", "PWY-6893", "PWY-6894", "PWY-6897", "PWY-6907", "PWY-6908", "PWY-7356", "PWY-8457" ]

[ "EC:2.5.1.3", "METACYC:PWY-6893", "METACYC:PWY-6894", "METACYC:PWY-6897", "METACYC:PWY-6907", "METACYC:PWY-6908", "METACYC:PWY-7356", "METACYC:PWY-8457" ]

8

[ "1g4e", "1g4p", "1g4s", "1g4t", "1g67", "1g69", "1g6c", "1xi3", "1yad", "2tps", "3ceu", "3nl2", "3nl3", "3nl5", "3nl6", "3nm1", "3nm3", "3o15", "3o16", "3o63", "3qh2" ]

21

[ "PUB00005784", "PUB00007481", "PUB00032610", "PUB00083112" ]

[ "9139923", "1898926", "15709744", "21534620" ]

[ "Characterization of the Bacillus subtilis thiC operon involved in thiamine biosynthesis.", "Cloning and characterization of a pair of novel genes that regulate production of extracellular enzymes in Bacillus subtilis.", "Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtili...

[ 1997, 1991, 2005, 2011 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 522, 33432, 2942, 463 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 9, 1, 1, 2, 1, 1, 10 ]

7

true

Domain

Thiamine phosphate synthase/TenI

ThiamineP_synth_TenI

5

IPR022999

22,999

Transaldolase type 3B, putative

Transaldolase_3B

Family

8,286

false

Transaldolase ( ) catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldo...

[ "GO:0004801" ]

[ "transaldolase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00494" ]

[ "Transaldolase_3b" ]

[ 8286 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.2.1.2", "PWY-1861", "PWY-5723" ]

[ "EC:2.2.1.2", "METACYC:PWY-1861", "METACYC:PWY-5723" ]

3

[ "1vpx", "1wx0", "3r8r", "3s0c", "3s1u", "3s1v", "3s1w", "3s1x", "4xz9", "6yr3", "6yre", "6yrh", "6yrm", "6yrt", "6ys0", "9ui2" ]

16

[ "PUB00005649" ]

[ "8109173" ]

[ "Lysine144 is essential for the catalytic activity of Saccharomyces cerevisiae transaldolase." ]

[ 1993 ]

1

[ "IPR004731" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 126, 8082, 4, 74 ]

4

[]

0

true

Family

Transaldolase type 3B, putative

Transaldolase_3B

2

IPR023000

23,000

Shikimate kinase, conserved site

Shikimate_kinase_CS

Conserved_site

21,539

false

This entry represents shikimate kinase ( ) catalyzes the fifth step in the biosynthesis from chorismate of the aromatic amino acids (the shikimate pathway) in bacteria (gene aroK or aroL), plants and in fungi (where it is part of a multifunctional enzyme which catalyzes five consecutive steps in this pathway). Shikimat...

[]

0

[ "PROSITE" ]

[ "PS01128" ]

[ "SHIKIMATE_KINASE" ]

[ 21539 ]

1

[ "EC", "METACYC", "REACTOME" ]

[ "2.7.1.71", "PWY-6163", "R-MTU-964903" ]

[ "EC:2.7.1.71", "METACYC:PWY-6163", "REACTOME:R-MTU-964903" ]

3

[ "1e6c", "1kag", "1l4u", "1l4y", "1shk", "1u8a", "1we2", "1zuh", "1zui", "1zyu", "2dfn", "2dft", "2g1j", "2g1k", "2iyq", "2iyr", "2iys", "2iyt", "2iyu", "2iyv", "2iyw", "2iyx", "2iyy", "2iyz", "2pt5", "2shk", "3baf", "3hr7", "3muf", "3n2e", "3nwj", "3trf"...

36

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 67, 18223, 2937, 312 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 11, 2, 1, 7, 1, 14 ]

6

true

Conserved_site

Shikimate kinase, conserved site

Shikimate_kinase_CS

2

IPR023001

23,001

Fructose-6-phosphate aldolase

F6P_aldolase

Family

1,045

false

Fructose-6-phosphate aldolases were originally thought to be transaldolases or transaldolase-related proteins. Instead, they perform a novel reaction, the cleavage or formation of fructose 6-phosphate [ ]. They belong to the class I aldolase family.

[ "GO:0016832" ]

[ "aldehyde-lyase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00496" ]

[ "F6P_aldolase" ]

[ 1045 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "4.1.2.-", "PWY-7085", "PWY-7089" ]

[ "EC:4.1.2.-", "METACYC:PWY-7085", "METACYC:PWY-7089" ]

3

[ "1l6w", "4rxf", "4rxg", "4rz4", "4s1f", "5zol", "7qxf", "8s7h", "8s7i", "9lkp", "9ll3" ]

11

[ "PUB00053971" ]

[ "11120740" ]

[ "Fructose-6-phosphate aldolase is a novel class I aldolase from Escherichia coli and is related to a novel group of bacterial transaldolases." ]

[ 2001 ]

1

[ "IPR004731" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta" ]

[ 1042, 3 ]

2

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Fructose-6-phosphate aldolase

F6P_aldolase

4

IPR023002

23,002

Glycerol-1-phosphate dehydrogenase, archaea

G1P_dehydrogenase_arc

Family

852

false

This entry represents archaeal glycerol-1-phosphate dehydrogenase . Glycerol-1-phosphate dehydrogenase is responsible for the formation of the archaeal-specific glycerophosphate backbone of phospholipids, G-1-P, from glycerone phosphate [ ], using either NADH or NADPH as a coenzyme [ ], and is primarily Zn 2+ -dependen...

[ "GO:0050492" ]

[ "glycerol-1-phosphate dehydrogenase [NAD(P)+] activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00497_A" ]

[ "G1P_dehydrogenase_A" ]

[ 852 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.1.1.261", "PWY-6349", "PWY-8365" ]

[ "EC:1.1.1.261", "METACYC:PWY-6349", "METACYC:PWY-8365" ]

3

[ "4rfl", "4rgq", "4rgv", "5fb3" ]

4

[ "PUB00043531", "PUB00043532", "PUB00081219", "PUB00081220", "PUB00081221", "PUB00081222" ]

[ "9348086", "9419225", "15876564", "15337120", "15066037", "12913312" ]

[ "Purification and properties of sn-glycerol-1-phosphate dehydrogenase from Methanobacterium thermoautotrophicum: characterization of the biosynthetic enzyme for the enantiomeric glycerophosphate backbone of ether polar lipids of Archaea.", "Did archaeal and bacterial cells arise independently from noncellular pre...

[ 1997, 1998, 2005, 2004, 2004, 2003 ]

6

[]

0

null

[ "Archaea", "Geodia barretti", "unclassified sequences" ]

[ 836, 1, 15 ]

3

[]

0

true

Family

Glycerol-1-phosphate dehydrogenase, archaea

G1P_dehydrogenase_arc

2

IPR023003

23,003

Glycerol-1-phosphate dehydrogenase, bacteria

G1P_dehydrogenase_bac

Family

53

false

Glycerol-1-phosphate dehydrogenase is found primarily as a Zn 2+ -dependent form in archaea (see ); however a Ni 2+ -dependent form has been found in Gram-positive bacteria [ ].

[ "GO:0050492" ]

[ "glycerol-1-phosphate dehydrogenase [NAD(P)+] activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00497_B" ]

[ "G1P_dehydrogenase_B" ]

[ 53 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.1.1.261", "PWY-6349", "PWY-8365" ]

[ "EC:1.1.1.261", "METACYC:PWY-6349", "METACYC:PWY-8365" ]

3

[ "9h4x" ]

1

[ "PUB00052581" ]

[ "18558723" ]

[ "Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis." ]

[ 2008 ]

1

[]

0

null

[ "Bacillales" ]

[ 53 ]

1

[]

0

true

Family

Glycerol-1-phosphate dehydrogenase, bacteria

G1P_dehydrogenase_bac

1

IPR023005

23,005

Nucleoside diphosphate kinase, active site

Nucleoside_diP_kinase_AS

Active_site

26,974

false

The sequence of NDK has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism [ ]. This entry covers the active site histidine. Nucleoside diphosphate kinases ( ) (NDK) are enzymes required for the synthesis of nucl...

[]

0

[ "PROSITE" ]

[ "PS00469" ]

[ "NDPK" ]

[ 26974 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "2.7.4.6", "PWY-6545", "PWY-7176", "PWY-7184", "PWY-7187", "PWY-7197", "PWY-7198", "PWY-7205", "PWY-7210", "PWY-7220", "PWY-7221", "PWY-7222", "PWY-7224", "PWY-7226", "PWY-7227", "PWY-8289", "R-BTA-499943", "R-BTA-6798695", "R-BTA-9748787", "R-BTA-9755088", "R-CFA-499943", ...

[ "EC:2.7.4.6", "METACYC:PWY-6545", "METACYC:PWY-7176", "METACYC:PWY-7184", "METACYC:PWY-7187", "METACYC:PWY-7197", "METACYC:PWY-7198", "METACYC:PWY-7205", "METACYC:PWY-7210", "METACYC:PWY-7220", "METACYC:PWY-7221", "METACYC:PWY-7222", "METACYC:PWY-7224", "METACYC:PWY-7226", "METACYC:PWY-7...

60

[ "1b99", "1be4", "1bhn", "1bux", "1ehw", "1f6t", "1hhq", "1hiy", "1jxv", "1kdn", "1leo", "1ncl", "1ndc", "1ndl", "1ndp", "1nhk", "1nlk", "1npk", "1nsk", "1nsp", "1nsq", "1nue", "1pku", "1s57", "1s59", "1s5z", "1u8w", "1vya", "1w7w", "1xiq", "1xqi", "1zs6"...

163

[ "PUB00000847", "PUB00002696" ]

[ "2175255", "1851158" ]

[ "A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase.", "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme." ]

[ 1990, 1991 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 416, 14196, 12008, 20, 334 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 18, 1, 16, 6, 1, 17, 18, 1, 14, 18, 1, 1, 31 ]

13

true

Active_site

Nucleoside diphosphate kinase, active site

Nucleoside_diP_kinase_AS

4

IPR023006

23,006

YchJ-like

Family

6,360

false

This entry represents UPF0225 protein YchJ and structurally related uncharacterised proteins from bacteria. These proteins contain a middle domain represented by .

[]

0

[ "HAMAP" ]

[ "MF_00612" ]

[ "UPF0225" ]

[ 6360 ]

1

[]

0

[ "9vxg" ]

1

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 6341, 19 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YchJ-like

1

IPR023007

23,007

Uncharacterised protein family UPF0232, actinobacteria

UPF0232_actinobac

Family

1,547

false

The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP" ]

[ "MF_00630" ]

[ "UPF0232" ]

[ 1547 ]

1

[]

0

[]

0

[]

0

[ "IPR007922" ]

[]

1

0

1

[ "Actinomycetes", "freshwater metagenome" ]

[ 1546, 1 ]

2

[]

0

true

Family

Uncharacterised protein family UPF0232, actinobacteria

UPF0232_actinobac

5

IPR023008

23,008

Uncharacterized MFS-type transporter YhhS-like

MFS_YhhS-like

Family

3,471

false

This is a family of uncharacterised bacterial transporters that includes YhhS [ ].

[]

0

[ "HAMAP" ]

[ "MF_01118" ]

[ "MFS_YhhS" ]

[ 3471 ]

1

[]

0

[]

0

[ "PUB00087085" ]

[ "22952739" ]

[ "Identification and analysis of the putative pentose sugar efflux transporters in Escherichia coli." ]

[ 2012 ]

1

[ "IPR011701" ]

[]

1

0

1

[ "Pseudomonadati", "mine drainage metagenome" ]

[ 3470, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterized MFS-type transporter YhhS-like

MFS_YhhS-like

3

IPR023009

23,009

Tyrosine recombinase XerC/XerD

Tyrosine_recombinase_XerC/XerD

Family

37,447

false

This entry represents a site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. XerD binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD compl...

[]

0

[ "HAMAP" ]

[ "MF_01808" ]

[ "Recomb_XerC_XerD" ]

[ 37447 ]

1

[]

0

[ "1a0p" ]

1

[ "PUB00054604", "PUB00054605", "PUB00054606", "PUB00054607" ]

[ "10361305", "7744017", "9268326", "10037776" ]

[ "C-terminal interactions between the XerC and XerD site-specific recombinases.", "Xer site-specific recombination in vitro.", "Xer recombination in Escherichia coli. Site-specific DNA topoisomerase activity of the XerC and XerD recombinases.", "Xer site-specific recombination. DNA strand rejoining by recombin...

[ 1999, 1995, 1997, 1999 ]

4

[]

[ "IPR011931", "IPR011932" ]

0

2

0

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences", "uncultured marine thaumarchaeote KM3_41_D11" ]

[ 36701, 2, 29, 714, 1 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Tyrosine recombinase XerC/XerD

Tyrosine_recombinase_XerC/XerD

6

IPR023010

23,010

Probable glycine dehydrogenase (decarboxylating) subunit 1

GcvPA

Family

6,440

false

This entry represents the probable glycine dehydrogenase (decarboxylating) subunit 1 from prokaryotes. The subunit composition of glycine cleavage system P-proteins have been classified into two types. Those from eukaryotes and some of the P-proteins from prokaryotes (e.g. Escherichia coli) are in the homodimeric form....

[ "GO:0004375", "GO:0009116" ]

[ "glycine dehydrogenase (decarboxylating) activity", "nucleoside metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PANTHER" ]

[ "MF_00712", "PIRSF006815", "PTHR42806" ]

[ "GcvPA", "GcvPA", "" ]

[ 4887, 5025, 6439 ]

3

[ "EC" ]

[ "1.4.4.2" ]

[ "EC:1.4.4.2" ]

1

[ "1wyt", "1wyu", "1wyv" ]

3

[ "PUB00038183" ]

[ "15791207" ]

[ "Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia." ]

[ 2005 ]

1

[ "IPR020581" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 536, 5542, 79, 283 ]

4

[]

0

true

Family

Probable glycine dehydrogenase (decarboxylating) subunit 1

GcvPA

2

IPR023011

23,011

ATP synthase, F0 complex, subunit A, active site

ATP_synth_F0_asu_AS

Active_site

71,792

false

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ...

[]

0

[ "PROSITE" ]

[ "PS00449" ]

[ "ATPASE_A" ]

[ 71792 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-163210", "R-BTA-5419276", "R-BTA-8949613", "R-BTA-9837999", "R-CEL-163210", "R-CEL-5419276", "R-CEL-8949613", "R-CEL-9837999", "R-DDI-9837999", "R-DME-163210", "R-DME-5419276", "R-DME-8949613", "R-DME-9837999", "R-DRE-163210", "R-DRE-8949613", "R-DRE-9837999", "R-GGA-163210", ...

[ "REACTOME:R-BTA-163210", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-8949613", "REACTOME:R-BTA-9837999", "REACTOME:R-CEL-163210", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-8949613", "REACTOME:R-CEL-9837999", "REACTOME:R-DDI-9837999", "REACTOME:R-DME-163210", "REACTOME:R-DME-5419276", "REACTOME:R...

38

[ "1c17", "5ara", "5are", "5arh", "5ari", "5dn6", "5fij", "5fik", "5fil", "5lqx", "5lqy", "5lqz", "5t4o", "5t4p", "5t4q", "6b2z", "6b8h", "6cp3", "6cp5", "6cp6", "6cp7", "6f36", "6fkf", "6fkh", "6fki", "6j54", "6j5a", "6j5i", "6j5j", "6j5k", "6n2d", "6n2y"...

234

[ "PUB00002531", "PUB00009752", "PUB00020603", "PUB00020604", "PUB00020607", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789" ]

[ "2536742", "11309608", "15473999", "15078220", "16045926", "20450191", "18937357", "1385979", "9741106" ]

[ "Proton translocation by the F1F0ATPase of Escherichia coli. Mutagenic analysis of the a subunit.", "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupl...

[ 1989, 2001, 2004, 2004, 2005, 2010, 2008, 1992, 1998 ]

9

[]

0

null

[ "Bacteria", "Eukaryota", "Pseudomonas phage PPAT", "Stenosarchaea group", "unclassified sequences" ]

[ 18273, 53061, 1, 28, 429 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 9, 8, 2, 18, 1, 1446, 9, 1, 7, 7, 1, 1, 7 ]

13

true

Active_site

ATP synthase, F0 complex, subunit A, active site

ATP_synth_F0_asu_AS

2

IPR023012

23,012

Probable glycine dehydrogenase (decarboxylating) subunit 2

GcvPB

Family

3,433

false

The P protein, also known as Glycine dehydrogenase (decarboxylating), is part of the glycine decarboxylase multienzyme complex (GDC), also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T [ ]. The P protein ( ) binds the alpha-amino group of glycine through its pyrid...

[ "GO:0004375", "GO:0019464" ]

[ "glycine dehydrogenase (decarboxylating) activity", "glycine decarboxylation via glycine cleavage system" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_00713" ]

[ "GcvPB" ]

[ 3433 ]

1

[ "EC" ]

[ "1.4.4.2" ]

[ "EC:1.4.4.2" ]

1

[ "1wyt", "1wyu", "1wyv" ]

3

[ "PUB00009491", "PUB00038183" ]

[ "8181752", "15791207" ]

[ "Characterization of the Escherichia coli gcv operon.", "Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia." ]

[ 1994, 2005 ]

2

[ "IPR020581" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Symbiodiniaceae", "unclassified sequences" ]

[ 112, 3271, 2, 48 ]

4

[]

0

true

Family

Probable glycine dehydrogenase (decarboxylating) subunit 2

GcvPB

3

IPR023013

23,013

N-acetyl-gamma-glutamyl-phosphate reductase, active site

AGPR_AS

Active_site

21,761

false

N -Acetylglutamate (NAG) fulfils distinct biological roles in lower and higher organisms. In prokaryotes, lower eukaryotes and plants it is the first intermediate in the biosynthesis of arginine, whereas in ureotelic (excreting nitrogen mostly in the form of urea) vertebrates, it is an essential allosteric cofactor for...

[ "GO:0003942" ]

[ "N-acetyl-gamma-glutamyl-phosphate reductase activity" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS01224" ]

[ "ARGC" ]

[ 21761 ]

1

[ "EC", "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.2.1", "1.2.1.38", "PWY-5154", "R-DDI-70635", "R-SCE-70635", "R-SPO-70635" ]

[ "EC:1.2.1", "EC:1.2.1.38", "METACYC:PWY-5154", "REACTOME:R-DDI-70635", "REACTOME:R-SCE-70635", "REACTOME:R-SPO-70635" ]

6

[ "1vkn", "1xyg", "2cvo", "2g17", "2i3a", "2i3g", "2nqt", "2ozp", "2q49", "3dr3", "5eio", "7nni", "7nnq", "7nnr", "7not", "7nph", "7npj", "8afu", "8afv" ]

19

[ "PUB00002190", "PUB00002893", "PUB00013503", "PUB00014499", "PUB00041590" ]

[ "1339424", "7907589", "1406250", "12633501", "17316682" ]

[ "Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production.", "A polyprotein precursor of two mitochondrial enzymes in Neurospora crassa. Gene structure and precursor processing.", "Isol...

[ 1992, 1994, 1992, 2003, 2007 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 307, 18637, 2395, 1, 421 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 1, 1, 6, 1, 1, 3 ]

7

true

Active_site

N-acetyl-gamma-glutamyl-phosphate reductase, active site

AGPR_AS

6

IPR023014

23,014

Fructose-bisphosphate aldolase class I, Gram-positive bacteria-type

FBA_I_Gram+-type

Family

739

false

Fructose-bisphosphate aldolase ( ) [ , ] is a glycolytic enzyme that catalyses the reversible aldol cleavage or condensation of fructose-1,6-bisphosphate into dihydroxyacetone-phosphate and glyceraldehyde 3-phosphate. There are two classes of fructose-bisphosphate aldolases with different catalytic mechanisms: class I ...

[ "GO:0004332", "GO:0006096" ]

[ "fructose-bisphosphate aldolase activity", "glycolytic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "CDD" ]

[ "MF_00729", "cd00949" ]

[ "FBP_aldolase_1", "FBP_aldolase_I_bact" ]

[ 655, 194 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.1.2.13", "PWY-1042", "PWY-1861", "PWY-5484", "PWY-6142", "PWY-7385", "PWY-8178", "PWY-8404" ]

[ "EC:4.1.2.13", "METACYC:PWY-1042", "METACYC:PWY-1861", "METACYC:PWY-5484", "METACYC:PWY-6142", "METACYC:PWY-7385", "METACYC:PWY-8178", "METACYC:PWY-8404" ]

8

[ "2iqt" ]

1

[ "PUB00000463", "PUB00000567", "PUB00005383" ]

[ "3355497", "2199259", "1412694" ]

[ "The complete amino acid sequence of human skeletal-muscle fructose-bisphosphate aldolase.", "The fructose-1,6-bisphosphate aldolases: same reaction, different enzymes.", "Fructose-bisphosphate aldolases: an evolutionary history." ]

[ 1988, 1990, 1992 ]

3

[ "IPR000741" ]

[]

1

0

1

[ "Bacteria" ]

[ 739 ]

1

[]

0

true

Family

Fructose-bisphosphate aldolase class I, Gram-positive bacteria-type

FBA_I_Gram+-type

5

IPR023016

23,016

HisA/PriA

Family

22,351

false

This protein family consists of HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, also known as 1-(5-phosphoribosyl)-5-(5-phosphoribosylamino methylideneamino) imidazole-4-carboxamide isomerase ( ), the enzyme catalyzing the fourth step in histidine biosynthesis. It is closely related to th...

[ "GO:0003949", "GO:0000105" ]

[ "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity", "L-histidine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "CDD" ]

[ "MF_01014", "cd04732" ]

[ "HisA", "HisA" ]

[ 22174, 22308 ]

2

[ "EC" ]

[ "5.3.1.16" ]

[ "EC:5.3.1.16" ]

1

[ "1qo2", "1vzw", "2cff", "2vep", "2w79", "2x30", "2y85", "2y88", "2y89", "3zs4", "4axk", "4gj1", "4tx9", "4u28", "4w9t", "4wd0", "4x2r", "4x9s", "5a5w", "5ab3", "5abt", "5ac6", "5ac7", "5ac8", "5ahe", "5ahf", "5ahi", "5dn1", "5g1t", "5g1y", "5g2h", "5g2i"...

38

[ "PUB00013823" ]

[ "12634849" ]

[ "Occurrence of a putative ancient-like isomerase involved in histidine and tryptophan biosynthesis." ]

[ 2003 ]

1

[ "IPR044524" ]

[ "IPR006063", "IPR010188" ]

1

2

0

[ "Archaea", "Bacteria", "Eukaryota", "phage Lak_Megaphage_Sonny", "unclassified sequences" ]

[ 751, 21111, 42, 1, 446 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

HisA/PriA

3

IPR023018

23,018

Transport protein YidE, putative

Transpt_YidE_put

Family

1,266

false

This entry represents a family of putative transport proteins from Gammaproteobacteria.

[]

0

[ "HAMAP" ]

[ "MF_01016" ]

[ "YidE" ]

[ 1266 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 1264, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transport protein YidE, putative

Transpt_YidE_put

8

IPR023019

23,019

Histidine biosynthesis bifunctional protein HisIE

His_synth_HisIE

Family

9,679

false

The HisI and HisE functions, phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase , are coded by a a single gene in E. coli and other bacteria [ ]. This entry represents bifunctional HisIE proteins. This entry also includes its plant homologues, such as HISN2 (At1g31860) from Arabidopsis [ ].

[ "GO:0004635", "GO:0004636", "GO:0000105" ]

[ "phosphoribosyl-AMP cyclohydrolase activity", "phosphoribosyl-ATP diphosphatase activity", "L-histidine biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_01019" ]

[ "HisIE" ]

[ 9679 ]

1

[ "EC", "EC" ]

[ "3.5.4.19", "3.6.1.31" ]

[ "EC:3.5.4.19", "EC:3.6.1.31" ]

2

[ "6j22", "6j2l" ]

2

[ "PUB00053975", "PUB00074101" ]

[ "3018428", "9733547" ]

[ "Nucleotide sequence of the Escherichia coli hisD gene and of the Escherichia coli and Salmonella typhimurium hisIE region.", "Isolation and characterization of a histidine biosynthetic gene in Arabidopsis encoding a polypeptide with two separate domains for phosphoribosyl-ATP pyrophosphohydrolase and phosphoribo...

[ 1986, 1998 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "phage Lak_Megaphage_Sonny" ]

[ 47, 9252, 292, 87, 1 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 5, 1 ]

2

true

Family

Histidine biosynthesis bifunctional protein HisIE

His_synth_HisIE

7

IPR023023

23,023

dNTP triphosphohydrolase, type 2

dNTPase_2

Family

10,536

false

This entry represents a subgroup of dNTP triphosphohydrolases, classified as type 2 dNTPases [ ]. Proteins in this entry includes TTHA0412 ( ) from Thermus thermophilus HB8. It hydrolyzes multiple kinds of dNTP upon activation by binding of an activator. Its dNTP triphosphohydrolase activity is stimulated by dATP and d...

[ "GO:0016793" ]

[ "triphosphoric monoester hydrolase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_01212" ]

[ "dGTPase_type2" ]

[ 10536 ]

1

[]

0

[ "2dqb", "7lwz", "9p8w" ]

3

[ "PUB00083218", "PUB00083223" ]

[ "19438719", "15496593" ]

[ "Two dNTP triphosphohydrolases from Pseudomonas aeruginosa possess diverse substrate specificities.", "Biochemical characterization of TT1383 from Thermus thermophilus identifies a novel dNTP triphosphohydrolase activity stimulated by dATP and dTTP." ]

[ 2009, 2004 ]

2

[ "IPR006261" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine group II/III euryarchaeote KM3_133_F10" ]

[ 10372, 12, 151, 1 ]

4

[]

0

true

Family

dNTP triphosphohydrolase, type 2

dNTPase_2

5

IPR023024

23,024

dNTP triphosphohydrolase, type 3

dNTPase_3

Family

22

false

This entry represents a subgroup of dNTP triphosphohydrolases, classified as type 3 dNTPases [ ]. This entry includes PA3043 ( ) from Pseudomonas aeruginosa. It is a dNTP triphosphohydrolase that hydrolyzes multiple kinds of dNTP without an activator [ ].

[ "GO:0016793" ]

[ "triphosphoric monoester hydrolase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_01213" ]

[ "dGTPase_type3" ]

[ 22 ]

1

[]

0

[]

0

[ "PUB00083218" ]

[ "19438719" ]

[ "Two dNTP triphosphohydrolases from Pseudomonas aeruginosa possess diverse substrate specificities." ]

[ 2009 ]

1

[ "IPR006261" ]

[]

1

0

1

[ "Bacteria" ]

[ 22 ]

1

[]

0

true

Family

dNTP triphosphohydrolase, type 3

dNTPase_3

4

IPR023025

23,025

Serine/threonine transporter SstT

Ser_Thr_transp_SstT

Family

5,201

false

This entry represents the SstT family of serine/threonine transporters. It is involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) [ , , ].

[ "GO:0015293", "GO:0015826", "GO:0032329" ]

[ "symporter activity", "threonine transport", "serine transport" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01582", "NF010151" ]

[ "Ser_Thr_transp_SstT", "PRK13628.1" ]

[ 5032, 5201 ]

2

[]

0

[]

0

[ "PUB00062328", "PUB00062329", "PUB00062330" ]

[ "12097162", "9852024", "11418553" ]

[ "Purification, reconstitution, and characterization of Na(+)/serine symporter, SstT, of Escherichia coli.", "Cloning and expression of the gene for the Na+-coupled serine transporter from Escherichia coli and characteristics of the transporter.", "Sodium ion-driven serine/threonine transport in Porphyromonas gi...

[ 2002, 1998, 2001 ]

3

[ "IPR001991" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobrevibacter", "metagenomes" ]

[ 5173, 9, 7, 12 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Serine/threonine transporter SstT

Ser_Thr_transp_SstT

3

IPR023026

23,026

Tryptophan synthase beta chain/beta chain-like

Trp_synth_beta/beta-like

Family

37,117

false

Tryptophan synthase catalyses the last step in the biosynthesis of tryptophan [ , ]: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H 2 O It has two functional domains, each found in bacteria and plants on a separate subunit: alpha chain ( ) is for the aldol cleavage of indo...

[ "GO:0004834", "GO:0000162" ]

[ "tryptophan synthase activity", "L-tryptophan biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PANTHER" ]

[ "MF_00133", "PIRSF001413", "PTHR48077" ]

[ "Trp_synth_beta", "Trp_syn_beta", "" ]

[ 32016, 30842, 37111 ]

3

[ "EC" ]

[ "4.2.1.20" ]

[ "EC:4.2.1.20" ]

1

[ "1a50", "1a5a", "1a5b", "1a5s", "1beu", "1bks", "1c29", "1c8v", "1c9d", "1cw2", "1cx9", "1fuy", "1k3u", "1k7e", "1k7f", "1k7x", "1k8x", "1k8y", "1k8z", "1kfb", "1kfc", "1kfe", "1kfj", "1kfk", "1qop", "1qoq", "1tjp", "1ttp", "1ttq", "1ubs", "1v8z", "1wbj"...

183

[ "PUB00000116", "PUB00000769", "PUB00004683" ]

[ "2679363", "1366510", "2734310" ]

[ "Evolution of a biosynthetic pathway: the tryptophan paradigm.", "The tryptophan synthase multienzyme complex: exploring structure-function relationships with X-ray crystallography and mutagenesis.", "A gene encoding the tryptophan synthase beta subunit of Arabidopsis thaliana." ]

[ 1989, 1990, 1989 ]

3

[]

[ "IPR006316", "IPR006654" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1342, 29924, 4944, 907 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 29, 1, 1, 9, 1, 1, 11 ]

7

true

Family

Tryptophan synthase beta chain/beta chain-like

Trp_synth_beta/beta-like

6

IPR023027

23,027

Mannitol dehydrogenase, conserved site

Mannitol_DH_CS

Conserved_site

13,285

false

Mannitol dehydrogenases catalyse the NAD-dependent reduction of mannitol-1-phosphates as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glyco...

[ "GO:0019594" ]

[ "mannitol metabolic process" ]

[ "biological_process" ]

1

[ "PROSITE" ]

[ "PS00974" ]

[ "MANNITOL_DHGENASE" ]

[ 13285 ]

1

[ "EC", "METACYC" ]

[ "1.1.1.17", "PWY-6531" ]

[ "EC:1.1.1.17", "METACYC:PWY-6531" ]

2

[ "1lj8", "1m2w", "3h2z", "4im7", "5jnm" ]

5

[ "PUB00002028", "PUB00003120" ]

[ "1322373", "8254318" ]

[ "Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system.", "Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodo...

[ 1992, 1993 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Viruses", "metagenomes" ]

[ 12921, 319, 2, 3, 40 ]

5

[ "Escherichia coli (strain K12)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 4, 2 ]

2

true

Conserved_site

Mannitol dehydrogenase, conserved site

Mannitol_DH_CS

5

IPR023028

23,028

Mannitol-1-phosphate 5-dehydrogenase

Mannitol_1_phos_5_DH

Family

5,398

false

Mannitol dehydrogenases catalyse the NAD-dependent reduction of mannitol-1-phosphates as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glyco...

[ "GO:0008926", "GO:0019594" ]

[ "mannitol-1-phosphate 5-dehydrogenase activity", "mannitol metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_00196" ]

[ "Mannitol_dehydrog" ]

[ 5398 ]

1

[ "EC", "METACYC" ]

[ "1.1.1.17", "PWY-6531" ]

[ "EC:1.1.1.17", "METACYC:PWY-6531" ]

2

[ "3h2z", "5jnm" ]

2

[ "PUB00002028", "PUB00003120" ]

[ "1322373", "8254318" ]

[ "Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system.", "Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodo...

[ 1992, 1993 ]

2

[ "IPR000669" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Halobacterium salinarum", "metagenomes" ]

[ 4308, 1081, 1, 8 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 1 ]

2

true

Family

Mannitol-1-phosphate 5-dehydrogenase

Mannitol_1_phos_5_DH

6

IPR023029

23,029

Small ribosomal subunit protein uS15, archaea/eukaryota

Ribosomal_uS15_arc_euk

Family

6,870

false

This entry contains the small ribosomal subunit protein uS15 from archaea and eukaryotes (also known as 30S ribosomal protein S15P/S13e and 40S ribosomal protein S13, respectively). Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribo...

[]

0

[ "HAMAP", "PANTHER" ]

[ "MF_01343_A", "PTHR11885" ]

[ "Ribosomal_uS15_A", "" ]

[ 5488, 6782 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-CEL-72706", "R-CEL-975956", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-179933...

100

[ "1ysh", "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q"...

638

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR000589" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 934, 4, 5884, 48 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 2, 3, 4, 1, 9, 16, 1, 1, 16 ]

12

true

Family

Small ribosomal subunit protein uS15, archaea/eukaryota

Ribosomal_uS15_arc_euk

7

IPR023030

23,030

Bifunctional protein HldE

Bifunc_HldE

Family

5,801

false

This entry represents the bifunctional protein HldE. It comprises D-beta-D-heptose 7-phosphate kinase [ec:2.7.1.-] and D-beta-D-heptose 1-phosphate adenosyltransferase [ec:2.7.7.-] activities.

[ "GO:0016773", "GO:0016779" ]

[ "phosphotransferase activity, alcohol group as acceptor", "nucleotidyltransferase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP" ]

[ "MF_01603" ]

[ "HldE" ]

[ 5801 ]

1

[ "EC", "EC" ]

[ "2.7.1.167", "2.7.7.70" ]

[ "EC:2.7.1.167", "EC:2.7.7.70" ]

2

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Nitrosopumilus salarius BD31", "Eukaryota", "unclassified sequences" ]

[ 5704, 1, 30, 66 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bifunctional protein HldE

Bifunc_HldE

8

IPR023032

23,032

tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

tRNA_MAMT_biosynth_bifunc_MnmC

Family

6,236

false

This entry represents the tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC. It has FAD-dependent oxidoreductase and methytransferase activity ([ec:1.5.-.-] and [ec:2.1.1.-] respectively).

[ "GO:0004808", "GO:0008168", "GO:0016645", "GO:0008033" ]

[ "tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity", "methyltransferase activity", "oxidoreductase activity, acting on the CH-NH group of donors", "tRNA processing" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "HAMAP" ]

[ "MF_01102" ]

[ "MnmC" ]

[ 6236 ]

1

[ "EC", "METACYC" ]

[ "2.1.1.61", "PWY-7892" ]

[ "EC:2.1.1.61", "METACYC:PWY-7892" ]

2

[ "3awi", "3ps9", "3pvc", "3sgl" ]

4

[]

0

[]

0

null

[ "Bacteria", "Fungi", "unclassified sequences" ]

[ 6194, 2, 40 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

tRNA_MAMT_biosynth_bifunc_MnmC

5

IPR023033

23,033

Alanine-tRNA ligase, eukaryota/bacteria

Ala_tRNA_ligase_euk/bac

Family

34,140

false

Alanine-tRNA ligase (also known as alanyl-tRNA synthetase) ( ) is an alpha4 tetramer that belongs to class IIc. Aminoacyl-tRNA synthetases (also known as aminoacyl-tRNA ligases) catalyse the attachment of amino acids to their cognate transfer RNA molecules through a highly specific two-step reaction [ , ]. These enzyme...

[ "GO:0004813" ]

[ "alanine-tRNA ligase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00036_B" ]

[ "Ala_tRNA_synth_B" ]

[ 34140 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "6.1.1.7", "R-HSA-379716", "R-HSA-379726" ]

[ "EC:6.1.1.7", "REACTOME:R-HSA-379716", "REACTOME:R-HSA-379726" ]

3

[ "1riq", "1yfr", "1yfs", "1yft", "1ygb", "3htz", "3hxu", "3hxv", "3hxw", "3hxx", "3hxy", "3hxz", "3hy0", "3hy1", "4xem", "4xeo", "5knn", "5v59", "9jc7", "9jdn" ]

20

[ "PUB00000386", "PUB00000723", "PUB00004391", "PUB00005365", "PUB00006477", "PUB00007191", "PUB00007363", "PUB00079872", "PUB00079873" ]

[ "8364025", "8274143", "1852601", "2053131", "10673435", "2203971", "10447505", "10704480", "12458790" ]

[ "Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.", "The aminoacyl-tRNA synthetase family: modules at work.", "Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.", "Classes of aminoacyl-tRNA synthetases and the establ...

[ 1993, 1993, 1991, 1991, 2000, 1990, 1999, 2000, 2002 ]

9

[ "IPR002318" ]

[ "IPR027522" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12, 26312, 7313, 503 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 10, 2, 5, 3, 1, 15, 5, 1, 5, 7, 1, 1, 18 ]

13

true

Family

Alanine-tRNA ligase, eukaryota/bacteria

Ala_tRNA_ligase_euk/bac

4

IPR023034

23,034

Peptidyl-prolyl isomerase SurA

PPIase_SurA

Family

5,917

false

SurA in Escherichia coli is a periplasmic peptidyl-prolyl isomerase which is necessary for the proper folding of outer membrane proteins (OMP) including OmpA, OmpF and LamB. There are at least two pathways for periplasmic chaperone activity, one involving Skp and DegP, and another involving SurA. It has been proposed t...

[ "GO:0003755", "GO:0042277", "GO:0051082", "GO:0006457", "GO:0043165", "GO:0050821", "GO:0030288" ]

[ "peptidyl-prolyl cis-trans isomerase activity", "peptide binding", "unfolded protein binding", "protein folding", "Gram-negative-bacterium-type cell outer membrane assembly", "protein stabilization", "outer membrane-bounded periplasmic space" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

7

[ "HAMAP" ]

[ "MF_01183" ]

[ "Chaperone_SurA" ]

[ 5917 ]

1

[ "EC", "REACTOME" ]

[ "5.2.1.8", "R-HSA-9760173" ]

[ "EC:5.2.1.8", "REACTOME:R-HSA-9760173" ]

2

[ "1m5y", "8pz1", "8pz2", "8pzu", "8pzv", "8q0g", "8qp5", "8qpu", "8qpv", "8qpw", "9hg5", "9hg6", "9hg7", "9hg8", "9hg9", "9hga" ]

16

[ "PUB00053976" ]

[ "19343722" ]

[ "Characterization of the role of the Escherichia coli periplasmic chaperone SurA using differential proteomics." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5846, 6, 65 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Peptidyl-prolyl isomerase SurA

PPIase_SurA

7

IPR023035

23,035

Small ribosomal subunit protein uS9, bacteria/plastid

Ribosomal_uS9_bact_plastid

Family

27,400

false

This entry represents bacterial, plastid and mitochondrial ribosomal uS9 proteins. Small ribosomal subunit protein uS9, previously known as S9, is required for central cell maturation and endosperm development in Arabidopsis thaliana [ ]. uS9 proteins adopt a β/α/β fold similar to that found in numerous RNA/DNA-binding...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_00532_B", "NF001099" ]

[ "Ribosomal_uS9_B", "PRK00132.1" ]

[ 24547, 27370 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

10

[ "1fjg", "1hnw", "1hnx", "1hnz", "1hr0", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1ml5", "1n32", "1n33", "1n34", "1n36", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xmo", "1xmq", "1xnq", "1xnr", "2e5l", "2f4v"...

1,247

[ "PUB00001585", "PUB00007068", "PUB00007069", "PUB00007070", "PUB00034480", "PUB00088388", "PUB00104058" ]

[ "2332055", "11297922", "11290319", "11114498", "8722013", "29312411", "3884974" ]

[ "The primary structure of rat ribosomal protein S16.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Structures of prokaryotic ribosomal proteins: implications for RNA binding and evolution.", "RPS9M, a...

[ 1990, 2001, 2001, 2000, 1995, 2017, 1985 ]

7

[ "IPR000754" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "candidate division MSBL1 archaeon SCGC-AAA382N08", "unclassified sequences" ]

[ 23327, 3592, 1, 480 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...

[ 10, 1, 1, 2, 3, 1, 9, 3, 1, 1, 8 ]

11

true

Family

Small ribosomal subunit protein uS9, bacteria/plastid

Ribosomal_uS9_bact_plastid

3

IPR023036

23,036

Small ribosomal subunit protein uS14, bacteria/plastid

Ribosomal_uS14_bact_plastid

Family

29,942

false

This entry includes bacterial and plastid small ribosomal subunit protein uS14. uS14 is one of the proteins from the small ribosomal subunit. In Escherichia coli, uS14 is known to be required for the assembly of 30S particles and may also be responsible for determining the conformation of 16S rRNA at the A site. It bel...

[]

0

[ "HAMAP" ]

[ "MF_00537" ]

[ "Ribosomal_uS14_1" ]

[ 29942 ]

1

[]

0

[ "2ykr", "3j9y", "3j9z", "3ja1", "3jbu", "3jbv", "3jcd", "3jce", "3jcj", "3jcn", "4a2i", "4adv", "4u1u", "4u1v", "4u20", "4u24", "4u25", "4u26", "4u27", "4v47", "4v48", "4v4h", "4v4q", "4v50", "4v52", "4v53", "4v54", "4v55", "4v56", "4v57", "4v5b", "4v5h"...

590

[ "PUB00004441", "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "8441676", "11297922", "11290319", "11114498" ]

[ "Zinc finger-like motifs in rat ribosomal proteins S27 and S29.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 1993, 2001, 2001, 2000 ]

4

[ "IPR001209" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 16027, 13737, 178 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 2, 2 ]

4

true

Family

Small ribosomal subunit protein uS14, bacteria/plastid

Ribosomal_uS14_bact_plastid

1