interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR023173 | 23,173 | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | NADPH_Cyt_P450_Rdtase_alpha | Homologous_superfamily | 36,894 | false | false | This superfamily represents the α-helical subdomain (domain 3) of the FAD-binding domain which can be found in NADPH-cytochrome P450 reductases [ ], nitric oxide synthases, NADPH-dependent diflavin oxidoreductases, and pyruvate dehydrogenases. | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"CATHGENE3D"
] | [
"G3DSA:1.20.990.10"
] | [
""
] | [
36894
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-156581",
"R-CEL-1614635",
"R-CEL-9759218",
"R-DDI-1222556",
"R-DDI-1474151",
"R-DDI-203615",
"R-DDI-203754",
"R-DDI-392154",
"R-DDI-5218920",
"R-DDI-5578775",
"R-DDI-9009391",
"R-DDI-9033241",
"R-DDI-9856530",
"R-DME-1222556",
"R-DME-1474151",
"R-DME-203615",
"R-DME-203754",
... | [
"REACTOME:R-CEL-156581",
"REACTOME:R-CEL-1614635",
"REACTOME:R-CEL-9759218",
"REACTOME:R-DDI-1222556",
"REACTOME:R-DDI-1474151",
"REACTOME:R-DDI-203615",
"REACTOME:R-DDI-203754",
"REACTOME:R-DDI-392154",
"REACTOME:R-DDI-5218920",
"REACTOME:R-DDI-5578775",
"REACTOME:R-DDI-9009391",
"REACTOME:R-... | 92 | [
"1amo",
"1ddg",
"1ddi",
"1f20",
"1j9z",
"1ja0",
"1ja1",
"1tll",
"2bf4",
"2bn4",
"2bpo",
"2qtl",
"2qtz",
"3es9",
"3fjo",
"3ojw",
"3ojx",
"3qe2",
"3qfc",
"3qfr",
"3qfs",
"3qft",
"3wkt",
"4dqk",
"4dql",
"4y7c",
"4y9r",
"4y9u",
"4yaf",
"4yal",
"4yao",
"4yau"... | 58 | [
"PUB00026312"
] | [
"11371558"
] | [
"NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
10455,
26379,
19,
41
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
16,
4,
34,
12,
1,
31,
14,
5,
11,
31,
3,
5,
34
] | 13 | true | Homologous_superfamily | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily | NADPH_Cyt_P450_Rdtase_alpha | 7 |
IPR023174 | 23,174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | PDEase_CS | Conserved_site | 48,072 | false | false | 3'5'-cyclic nucleotide phosphodiesterases ( ) (PDEases) catalyse the hydrolysis of cAMP or cGMP to the corresponding nucleoside 5' monophosphates [ ]. There are at least seven different subfamilies of PDEases [ ]: Type 1, calmodulin/calcium-dependent PDEases. Type 2, cGMP-stimulated PDEases. Type 3, cGMP-inhibited PDEa... | [
"GO:0008081"
] | [
"phosphoric diester hydrolase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00126"
] | [
"PDEASE_I_1"
] | [
48072
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.1.4",
"R-BTA-111957",
"R-BTA-418457",
"R-BTA-418555",
"R-BTA-445355",
"R-BTA-9013422",
"R-CEL-111957",
"R-CEL-165160",
"R-CEL-180024",
"R-CEL-418457",
"R-CEL-418555",
"R-CEL-9860927",
"R-CFA-2485179",
"R-CFA-2514859",
"R-CFA-4086398",
"R-CFA-418457",
"R-CFA-445355",
"R-CFA-90134... | [
"EC:3.1.4",
"REACTOME:R-BTA-111957",
"REACTOME:R-BTA-418457",
"REACTOME:R-BTA-418555",
"REACTOME:R-BTA-445355",
"REACTOME:R-BTA-9013422",
"REACTOME:R-CEL-111957",
"REACTOME:R-CEL-165160",
"REACTOME:R-CEL-180024",
"REACTOME:R-CEL-418457",
"REACTOME:R-CEL-418555",
"REACTOME:R-CEL-9860927",
"RE... | 65 | [
"1f0j",
"1mkd",
"1oyn",
"1ptw",
"1q9m",
"1rkp",
"1ro6",
"1ro9",
"1ror",
"1so2",
"1soj",
"1t9r",
"1t9s",
"1taz",
"1tb5",
"1tb7",
"1tbb",
"1tbf",
"1udt",
"1udu",
"1uho",
"1xlx",
"1xlz",
"1xm4",
"1xm6",
"1xmu",
"1xmy",
"1xn0",
"1xom",
"1xon",
"1xoq",
"1xor"... | 720 | [
"PUB00004628",
"PUB00005554",
"PUB00022735",
"PUB00024730",
"PUB00088645"
] | [
"3025833",
"2159198",
"15260978",
"10846163",
"17305581"
] | [
"Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species.",
"Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors.",
"A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases.",
"Atomic structu... | [
1986,
1990,
2004,
2000,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Thermoproteota archaeon",
"metagenomes"
] | [
33,
48035,
1,
3
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
16,
241,
29,
98,
104,
1,
165,
1
] | 8 | true | Conserved_site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | PDEase_CS | 3 |
IPR023175 | 23,175 | Vta1/Callose synthase, N-terminal domain superfamily | Vta1/CALS_N_sf | Homologous_superfamily | 9,552 | false | false | This superfamily represents the N-terminal domain of vacuolar protein sorting-associated proteins and callose synthases. This domain contains seven α helices arranged into two antiparallel three-helix bundle modules. It has been proposed that vacuolar protein sorting-associated protein Vta1 interacts with Vps60 and Vps... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.25.40.270"
] | [
""
] | [
9552
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-917729",
"R-HSA-162588",
"R-HSA-917729",
"R-MMU-917729",
"R-SCE-917729",
"R-SPO-917729"
] | [
"REACTOME:R-DDI-917729",
"REACTOME:R-HSA-162588",
"REACTOME:R-HSA-917729",
"REACTOME:R-MMU-917729",
"REACTOME:R-SCE-917729",
"REACTOME:R-SPO-917729"
] | 6 | [
"2luh",
"2lxl",
"2lxm",
"2rkk",
"4txp",
"4txq",
"4txr",
"4u7e",
"5h7p",
"5uie",
"5xmk",
"6ap1"
] | 12 | [
"PUB00049406"
] | [
"18194651"
] | [
"Structural basis of Vta1 function in the multivesicular body sorting pathway."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
2,
9550
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
57,
1,
2,
2,
4,
4,
1,
25,
3,
1,
1,
103
] | 12 | true | Homologous_superfamily | Vta1/Callose synthase, N-terminal domain superfamily | Vta1/Callose synthase, N-terminal domain superfamily | Vta1/CALS_N_sf | 9 |
IPR023176 | 23,176 | Orbivirus inner capsid protein VP7, N-terminal | Orbi_VP7_capsid_N | Homologous_superfamily | 618 | false | false | The bluetongue virus (BTV) is a representative of the orbivirus genus of the Reoviridae. The crystal structure of VP7 from BTV serotype 10 reveals that the central one third of the polypeptide chain (residues 121-249) is folded into a β-sandwich. The rest of the polypeptide (residues 1-120 and 250-349) is composed of n... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.250.10"
] | [
""
] | [
618
] | 1 | [] | [] | [] | 0 | [
"1bvp",
"2btv"
] | 2 | [
"PUB00004198"
] | [
"7816101"
] | [
"The crystal structure of bluetongue virus VP7."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Riboviria"
] | [
618
] | 1 | [] | [] | 0 | true | Homologous_superfamily | Orbivirus inner capsid protein VP7, N-terminal | Orbivirus inner capsid protein VP7, N-terminal | Orbi_VP7_capsid_N | 8 |
IPR023178 | 23,178 | Orbivirus inner capsid protein VP7, C-terminal | Orbi_VP7_capsid_C | Homologous_superfamily | 618 | false | false | The bluetongue virus (BTV) is a representative of the orbivirus genus of the Reoviridae. The crystal structure of VP7 from BTV serotype 10 reveals that the central one third of the polypeptide chain (residues 121-249) is folded into a β-sandwich. The rest of the polypeptide (residues 1-120 and 250-349) is composed of n... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.170.10"
] | [
""
] | [
618
] | 1 | [] | [] | [] | 0 | [
"1bvp",
"2btv"
] | 2 | [
"PUB00004198"
] | [
"7816101"
] | [
"The crystal structure of bluetongue virus VP7."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Riboviria"
] | [
618
] | 1 | [] | [] | 0 | true | Homologous_superfamily | Orbivirus inner capsid protein VP7, C-terminal | Orbivirus inner capsid protein VP7, C-terminal | Orbi_VP7_capsid_C | 3 |
IPR023179 | 23,179 | GTP-binding protein, orthogonal bundle domain superfamily | GTP-bd_ortho_bundle_sf | Homologous_superfamily | 24,972 | false | false | This superfamily represents a orthogonal bundle domain found in some GTP-binding proteins, including YlgF from Bacillus subtilis. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.1580.10"
] | [
""
] | [
24972
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6791226",
"R-DDI-6791226",
"R-DME-6791226",
"R-MMU-6791226",
"R-RNO-6791226",
"R-SCE-6791226",
"R-SPO-6791226",
"R-XTR-6791226"
] | [
"REACTOME:R-CEL-6791226",
"REACTOME:R-DDI-6791226",
"REACTOME:R-DME-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226",
"REACTOME:R-XTR-6791226"
] | 8 | [
"1puj",
"3cnl",
"3cnn",
"3cno",
"3jct",
"6elz",
"6em1",
"6em5",
"6ft6",
"6g0z",
"6g12",
"6g14",
"6g15",
"6lss",
"6lu8",
"6m62",
"6n8j",
"6ppk",
"6ylg",
"6ylh",
"6ylx",
"6yly",
"6yxx",
"6yxy",
"7am2",
"7bt6",
"7btb",
"7nac",
"7o9k",
"7of1",
"7oh3",
"7ohq"... | 95 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
269,
8015,
16612,
76
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
29,
6,
7,
5,
11,
9,
4,
16,
11,
2,
4,
38
] | 12 | true | Homologous_superfamily | GTP-binding protein, orthogonal bundle domain superfamily | GTP-binding protein, orthogonal bundle domain superfamily | GTP-bd_ortho_bundle_sf | 7 |
IPR023180 | 23,180 | Tetrahydrodipicolinate-N-succinyltransferase, chain A, domain 1 | THP_succinylTrfase_dom1 | Domain | 10,715 | false | false | This entry represents the N-terminal domain of the enzyme tetrahydrodipicolinate-N-succinyltransferase [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF14805"
] | [
"THDPS_N_2"
] | [
10715
] | 1 | [
"EC"
] | [
"2.3.1.117"
] | [
"EC:2.3.1.117"
] | 1 | [
"1kgq",
"1kgt",
"1tdt",
"2tdt",
"3bxy",
"3eg4",
"3gos",
"3tdt",
"3tk8",
"6amy",
"6amz",
"6ckt",
"6wqm",
"9o8n",
"9o8y"
] | 15 | [
"PUB00032914"
] | [
"9671504"
] | [
"The conformational change and active site structure of tetrahydrodipicolinate N-succinyltransferase."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
10211,
31,
321,
152
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Tetrahydrodipicolinate-N-succinyltransferase, chain A, domain 1 | Tetrahydrodipicolinate-N-succinyltransferase, chain A, domain 1 | THP_succinylTrfase_dom1 | 6 |
IPR023181 | 23,181 | Homospermidine synthase-like, C-terminal | Homospermid_syn-like_C | Homologous_superfamily | 2,137 | false | false | This superfamily represents the C-terminal domain, which is a 2-layer α/β sandwich, found in homospermidine synthase and related proteins. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:3.30.360.30"
] | [
""
] | [
2137
] | 1 | [] | [] | [] | 0 | [
"2ph5",
"4plp",
"4tvb",
"4xq9",
"4xqc",
"4xqe",
"4xqg",
"4xr4",
"4xrg",
"6s3x",
"6s49",
"6s4d",
"6s65",
"6s6g",
"6s72",
"6sep",
"6y87"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"Viruses",
"metagenomes"
] | [
1928,
75,
36,
17,
81
] | 5 | [] | [] | 0 | true | Homologous_superfamily | Homospermidine synthase-like, C-terminal | Homospermidine synthase-like, C-terminal | Homospermid_syn-like_C | 2 |
IPR023183 | 23,183 | Serine protease, chymotrypsin-like serine protease, C-terminal | Chymotrypsin-like_C | Homologous_superfamily | 1,412 | false | false | The replicase polyprotein 1ab is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products. Nsp1 is essential for vira... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:3.30.40.20"
] | [
""
] | [
1412
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC"
] | [
"2.7.7.48",
"3.4.19.12",
"3.4.21.-",
"3.4.22.-",
"3.6.4.12",
"3.6.4.13",
"4.6.1.-",
"PWY-7884"
] | [
"EC:2.7.7.48",
"EC:3.4.19.12",
"EC:3.4.21.-",
"EC:3.4.22.-",
"EC:3.6.4.12",
"EC:3.6.4.13",
"EC:4.6.1.-",
"METACYC:PWY-7884"
] | 8 | [
"1mbm",
"3fan",
"3fao",
"5y4l"
] | 4 | [
"PUB00027289",
"PUB00054018",
"PUB00054019"
] | [
"12163505",
"18078692",
"9371590"
] | [
"Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole.",
"Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses.",
"Alternative proteolytic processi... | [
2002,
2007,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Arteriviridae"
] | [
1412
] | 1 | [] | [] | 0 | true | Homologous_superfamily | Serine protease, chymotrypsin-like serine protease, C-terminal | Serine protease, chymotrypsin-like serine protease, C-terminal | Chymotrypsin-like_C | 5 |
IPR023184 | 23,184 | Ubiquinol-cytochrome C reductase hinge domain | Ubol_cytC_Rdtase_hinge_dom | Domain | 4,701 | false | false | The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex [ ]. The bc1 complex contains 11 subunits; 3 respiratory subunits (cytochrome B, cytochrome C1, Rieske protein), 2 core proteins and 6 low molecular weight proteins. This family represents the 'hinge' protein of t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02320"
] | [
"UCR_hinge"
] | [
4701
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-611105",
"R-BTA-9865881",
"R-DDI-611105",
"R-HSA-611105",
"R-HSA-9865881",
"R-MMU-611105",
"R-MMU-9865881",
"R-RNO-611105",
"R-RNO-9865881",
"R-SCE-611105",
"R-SCE-9865878",
"R-SPO-611105"
] | [
"REACTOME:R-BTA-611105",
"REACTOME:R-BTA-9865881",
"REACTOME:R-DDI-611105",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-9865881",
"REACTOME:R-MMU-611105",
"REACTOME:R-MMU-9865881",
"REACTOME:R-RNO-611105",
"REACTOME:R-RNO-9865881",
"REACTOME:R-SCE-611105",
"REACTOME:R-SCE-9865878",
"REACTOME:R-SP... | 12 | [
"1bcc",
"1be3",
"1bgy",
"1ezv",
"1kb9",
"1kyo",
"1l0l",
"1l0n",
"1ntk",
"1ntm",
"1ntz",
"1nu1",
"1p84",
"1pp9",
"1ppj",
"1qcr",
"1sqb",
"1sqp",
"1sqq",
"1sqv",
"1sqx",
"2a06",
"2bcc",
"2fyu",
"2ibz",
"2ybb",
"3bcc",
"3cwb",
"3cx5",
"3cxh",
"3h1h",
"3h1i"... | 186 | [
"PUB00006415"
] | [
"9651245"
] | [
"Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4701
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
3,
3,
3,
1,
8,
4,
1,
1,
15
] | 12 | true | Domain | Ubiquinol-cytochrome C reductase hinge domain | Ubiquinol-cytochrome C reductase hinge domain | Ubol_cytC_Rdtase_hinge_dom | 2 |
IPR023186 | 23,186 | Inosine/uridine-preferring nucleoside hydrolase | IUNH | Family | 30,221 | false | false | Inosine-uridine preferring nucleoside hydrolase ( ) (IU-nucleoside hydrolase or IUNH) is an enzyme first identified in protozoan [ ] that catalyses the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12304"
] | [
""
] | [
30221
] | 1 | [] | [] | [] | 0 | [
"1ezr",
"1hoz",
"1hp0",
"1kic",
"1kie",
"1mas",
"1q8f",
"1r4f",
"1yoe",
"2c40",
"2ff1",
"2ff2",
"2mas",
"3b9g",
"3b9x",
"3epw",
"3epx",
"3g5i",
"3mkm",
"3mkn",
"3t8j",
"4i70",
"4i71",
"4i72",
"4i73",
"4i74",
"4i75",
"4kpn",
"4kpo",
"4wr2",
"5tsq",
"6ba0"... | 46 | [
"PUB00000434",
"PUB00000435"
] | [
"8634237",
"8634238"
] | [
"Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue.",
"Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata."
] | [
1996,
1996
] | 2 | [] | [
"IPR022975",
"IPR022976",
"IPR022977"
] | 0 | 3 | 0 | [
"Archaea",
"Bacillus phage PHBA67-J",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
158,
1,
23678,
6120,
264
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
6,
3,
2,
7,
1,
3,
60
] | 7 | true | Family | Inosine/uridine-preferring nucleoside hydrolase | Inosine/uridine-preferring nucleoside hydrolase | IUNH | 1 |
IPR023187 | 23,187 | Transcriptional regulator MarR-type, conserved site | Tscrpt_reg_MarR-type_CS | Conserved_site | 69,874 | false | false | This entry represents a 34 residue conserved site showing high conservation within this family. The MarR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 135 amino acids present in transcription regulators of the MarR/SlyA family, involved in the development of antibiotic resistance. The... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS01117"
] | [
"HTH_MARR_1"
] | [
69874
] | 1 | [] | [] | [] | 0 | [
"1jgs",
"1lj9",
"2a61",
"2bv6",
"2eth",
"2fa5",
"2fbh",
"2fxa",
"2nyx",
"3bdd",
"3bpv",
"3bpx",
"3deu",
"3fm5",
"3g3z",
"3nqo",
"3oop",
"3q5f",
"3qpt",
"3s2w",
"3vb2",
"3vod",
"3voe",
"4aih",
"4aij",
"4aik",
"4b8x",
"4em0",
"4em1",
"4em2",
"4jba",
"4mnu"... | 65 | [
"PUB00015407",
"PUB00015408",
"PUB00015409",
"PUB00015410"
] | [
"10498949",
"10094687",
"11473263",
"12649270"
] | [
"The mar regulon: multiple resistance to antibiotics and other toxic chemicals.",
"BadR, a new MarR family member, regulates anaerobic benzoate degradation by Rhodopseudomonas palustris in concert with AadR, an Fnr family member.",
"The crystal structure of MarR, a regulator of multiple antibiotic resistance, a... | [
1999,
1999,
2001,
2003
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
303,
69157,
38,
2,
374
] | 5 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Conserved_site | Transcriptional regulator MarR-type, conserved site | Transcriptional regulator MarR-type, conserved site | Tscrpt_reg_MarR-type_CS | 7 |
IPR023188 | 23,188 | DNA-binding protein Dps, conserved site | DPS_DNA-bd_CS | Conserved_site | 18,434 | false | false | Escherichia coli protein Dps [ ] is a DNA-binding protein, synthesized during prolonged starvation, that seems to protect DNA from oxidative damage. Dps binds DNA without any apparent sequence specificity. It is a protein of about 19 Kd that associates into a complex of 12 subunits forming two stacked hexameric rings. ... | [
"GO:0016722"
] | [
"oxidoreductase activity, acting on metal ions"
] | [
"molecular_function"
] | 1 | [
"PROSITE",
"PROSITE"
] | [
"PS00818",
"PS00819"
] | [
"DPS_1",
"DPS_2"
] | [
16365,
10210
] | 2 | [] | [] | [] | 0 | [
"1dps",
"1f30",
"1f33",
"1ji4",
"1ji5",
"1jig",
"1jre",
"1jts",
"1l8h",
"1l8i",
"1n1q",
"1o9r",
"1qgh",
"1uvh",
"1vei",
"1vel",
"1veq",
"2bjy",
"2bk6",
"2bkc",
"2c2f",
"2c2u",
"2c41",
"2chp",
"2d5k",
"2f7n",
"2fjc",
"2iy4",
"2vxx",
"2wla",
"2wlu",
"2xgw"... | 97 | [
"PUB00001907"
] | [
"1340475"
] | [
"A novel DNA-binding protein with regulatory and protective roles in starved Escherichia coli."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
147,
18112,
32,
74,
69
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Conserved_site | DNA-binding protein Dps, conserved site | DNA-binding protein Dps, conserved site | DPS_DNA-bd_CS | 5 |
IPR023191 | 23,191 | Deoxynucleotide monophosphate kinase, N-terminal | DNMP_kinase_N | Homologous_superfamily | 398 | false | false | Nucleotide monophosphate (NMP) kinases catalyse the phosphorylation of canonical nucleotides to the corresponding diphosphate using ATP as a phosphate donor [ ]. The bacteriophage T4 deoxynucleotide monophosphate (DNMP) kinases are unique in their ability to recognise three structurally dissimilar mononucleotides: dGMP... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.238.70"
] | [
""
] | [
398
] | 1 | [] | [] | [] | 0 | [
"1dek",
"1del"
] | 2 | [
"PUB00028349"
] | [
"8670851"
] | [
"Crystal structure of bacteriophage T4 deoxynucleotide kinase with its substrates dGMP and ATP."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"viral metagenome"
] | [
14,
381,
3
] | 3 | [] | [] | 0 | true | Homologous_superfamily | Deoxynucleotide monophosphate kinase, N-terminal | Deoxynucleotide monophosphate kinase, N-terminal | DNMP_kinase_N | 5 |
IPR023192 | 23,192 | TGS-like domain superfamily | TGS-like_dom_sf | Homologous_superfamily | 32,441 | false | false | This superfamily represents an α-helical TGS-like domain, which is found in the GTP1/OBG family which function as GTPases and ATPases [ ]. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.150.300"
] | [
""
] | [
32441
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-114608",
"R-CEL-114608",
"R-DME-114608",
"R-DRE-114608",
"R-GGA-114608",
"R-HSA-114608",
"R-MMU-114608",
"R-RNO-114608",
"R-SCE-114608",
"R-SPO-114608",
"R-XTR-114608"
] | [
"REACTOME:R-BTA-114608",
"REACTOME:R-CEL-114608",
"REACTOME:R-DME-114608",
"REACTOME:R-DRE-114608",
"REACTOME:R-GGA-114608",
"REACTOME:R-HSA-114608",
"REACTOME:R-MMU-114608",
"REACTOME:R-RNO-114608",
"REACTOME:R-SCE-114608",
"REACTOME:R-SPO-114608",
"REACTOME:R-XTR-114608"
] | 11 | [
"1jal",
"1ni3",
"2dby",
"2dwq",
"2ohf",
"5ee0",
"5ee1",
"5ee3",
"5ee9",
"7y9i",
"8kie",
"8w51"
] | 12 | [
"PUB00036769"
] | [
"17430889"
] | [
"Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
24804,
7122,
2,
513
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
1,
3,
4,
1,
4,
4,
1,
4,
4,
2,
2,
22
] | 13 | true | Homologous_superfamily | TGS-like domain superfamily | TGS-like domain superfamily | TGS-like_dom_sf | 6 |
IPR023193 | 23,193 | 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site | EPSP_synthase_CS | Conserved_site | 29,527 | false | false | This entry represents 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase (also known as 3-phosphoshikimate 1-carboxyvinyltransferase), catalyses the sixth step in the biosynthesis from chorismate of the aromatic amino acids (the shikimate pathway) in bacteria (gene aroA), plants and fungi (where it is part of a multifu... | [] | [] | [] | 0 | [
"PROSITE",
"PROSITE"
] | [
"PS00104",
"PS00885"
] | [
"EPSP_SYNTHASE_1",
"EPSP_SYNTHASE_2"
] | [
23225,
26924
] | 2 | [
"EC",
"METACYC",
"REACTOME"
] | [
"2.5.1.19",
"PWY-6163",
"R-MTU-964903"
] | [
"EC:2.5.1.19",
"METACYC:PWY-6163",
"REACTOME:R-MTU-964903"
] | 3 | [
"1eps",
"1g6s",
"1g6t",
"1mi4",
"1p88",
"1p89",
"1q36",
"1rf4",
"1rf5",
"1rf6",
"1x8r",
"1x8t",
"2aa9",
"2aay",
"2bjb",
"2gg4",
"2gg6",
"2gga",
"2ggd",
"2o0b",
"2o0d",
"2o0e",
"2o0x",
"2o0z",
"2o15",
"2pq9",
"2pqb",
"2pqc",
"2pqd",
"2qfq",
"2qfs",
"2qft"... | 65 | [
"PUB00002670",
"PUB00004745",
"PUB00039208",
"PUB00043314",
"PUB00043315"
] | [
"1939260",
"11607190",
"16225867",
"18051609",
"11300775"
] | [
"Site-directed mutagenesis of a conserved region of the 5-enolpyruvylshikimate-3-phosphate synthase active site.",
"Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold.",
"Molecular basis for the glyphosate-insensitivity of the reac... | [
1991,
1991,
2005,
2007,
2001
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"virus sp. ctHJb31"
] | [
733,
25036,
3154,
603,
1
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
12,
1,
1,
6,
1,
1,
3
] | 7 | true | Conserved_site | 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site | 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site | EPSP_synthase_CS | 9 |
IPR023194 | 23,194 | Eukaryotic translation initiation factor 3-like domain superfamily | eIF3-like_dom_sf | Homologous_superfamily | 4,743 | false | false | At least eleven different protein factors are involved in initiation of protein synthesis in eukaryotes. Binding of initiator tRNA and mRNA to the 40S subunit requires the presence of the translation initiation factors eIF-2 and eIF-3, with eIF-3 being particularly important for 80S ribosome dissociation and mRNA bindi... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.246.60"
] | [
""
] | [
4743
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-DDI-156827",
"R-DDI-72689",
"R-DDI-72695",
"R-DDI-72702",
"R-DME-156827",
"R-DME-72649",
"R-DME-72689",
"R-DME-72695",
"R-DME-72702",
"R-DRE-156827",
"R-DRE-72689",
"R-DRE-72695",
"R-DRE-72702",
"R-GGA... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72695",
"REACTOME:R-BTA-72702",
"REACTOME:R-DDI-156827",
"REACTOME:R-DDI-72689",
"REACTOME:R-DDI-72695",
"REACTOME:R-DDI-72702",
"REACTOME:R-DME-156827",
"REACTOME:R-DME-72649",
"REACTOME:R-DME-72689",
"... | 53 | [
"3bpj",
"6ybw",
"6zce",
"6zmw",
"6zvj",
"7a1g",
"8cah"
] | 7 | [
"PUB00054024",
"PUB00054025"
] | [
"1742346",
"16829125"
] | [
"Eukaryotic initiation factors eIF-2 and eIF-3: interactions, structure and localization in ribosomal initiation complexes.",
"Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer."
] | [
1991,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4743
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
3,
2,
3,
5,
1,
5,
4,
1,
1,
10
] | 12 | true | Homologous_superfamily | Eukaryotic translation initiation factor 3-like domain superfamily | Eukaryotic translation initiation factor 3-like domain superfamily | eIF3-like_dom_sf | 9 |
IPR023195 | 23,195 | Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal | Nict_dMeBzImd_PRibTrfase_N | Homologous_superfamily | 15,578 | false | false | Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin [ ]. It is one of the enzymes of the anaerobic pathway of cobalamin biosynthesis, and one of the four ... | [
"GO:0008939"
] | [
"nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.1610.10"
] | [
""
] | [
15578
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.4.2.21",
"PWY-5509",
"PWY-6269",
"PWY-7964",
"PWY-7965",
"PWY-7966",
"PWY-7967",
"PWY-7968",
"PWY-7969",
"PWY-7970"
] | [
"EC:2.4.2.21",
"METACYC:PWY-5509",
"METACYC:PWY-6269",
"METACYC:PWY-7964",
"METACYC:PWY-7965",
"METACYC:PWY-7966",
"METACYC:PWY-7967",
"METACYC:PWY-7968",
"METACYC:PWY-7969",
"METACYC:PWY-7970"
] | 10 | [
"1d0s",
"1d0v",
"1j33",
"1jh8",
"1jha",
"1jhm",
"1jho",
"1jhp",
"1jhq",
"1jhr",
"1jhu",
"1jhv",
"1jhx",
"1jhy",
"1l4b",
"1l4e",
"1l4f",
"1l4g",
"1l4h",
"1l4k",
"1l4l",
"1l4m",
"1l4n",
"1l5f",
"1l5k",
"1l5l",
"1l5m",
"1l5n",
"1l5o",
"1wx1",
"4hdk",
"4hdm"... | 42 | [
"PUB00009745",
"PUB00014667",
"PUB00014670",
"PUB00014672",
"PUB00015874",
"PUB00015996"
] | [
"7592411",
"12196148",
"8550510",
"11153269",
"12101181",
"8206834"
] | [
"The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli.",
"Biosynthesis of cobalamin (vitamin B(12)).",
"Salmonella typhimurium cobalamin (vitamin B12) biosynthetic genes: functional studies in S. typhimurium and Escherichia coli.",
"Multiple biosynthetic pathways for vitamin B12: variations on ... | [
1995,
2002,
1996,
2001,
2002,
1994
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
29,
15280,
98,
171
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Homologous_superfamily | Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal | Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal | Nict_dMeBzImd_PRibTrfase_N | 9 |
IPR023196 | 23,196 | Phosducin, N-terminal domain superfamily | Phosducin_N_dom_sf | Homologous_superfamily | 2,919 | false | false | The outer and inner segments of vertebrate rod photoreceptor cells contain phosducin, a soluble phosphoprotein that complexes with the beta/gamma-subunits of the GTP-binding protein, transducin. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of phosducin by protein kinase A [ ]. The prot... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.168.10"
] | [
""
] | [
2919
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6814122",
"R-DME-6814122",
"R-HSA-6814122",
"R-MMU-6814122",
"R-RNO-6814122"
] | [
"REACTOME:R-BTA-6814122",
"REACTOME:R-DME-6814122",
"REACTOME:R-HSA-6814122",
"REACTOME:R-MMU-6814122",
"REACTOME:R-RNO-6814122"
] | 5 | [
"1a0r",
"1b9x",
"1b9y",
"2trc",
"8sff",
"8sg8",
"8sgc",
"8sh9",
"8sha",
"8shf",
"8shg",
"8shl",
"8sho",
"8shp",
"8shq",
"8sht"
] | 16 | [
"PUB00001790",
"PUB00002577",
"PUB00028150"
] | [
"2210381",
"2203790",
"9739091"
] | [
"Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland.",
"Amino acid and cDNA sequence of bovine phosducin, a soluble phosphoprotein from photoreceptor cells.",
"Phosducin induces a structural change in transducin beta gamma."
] | [
1990,
1990,
1998
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2919
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
6,
7,
9
] | 6 | true | Homologous_superfamily | Phosducin, N-terminal domain superfamily | Phosducin, N-terminal domain superfamily | Phosducin_N_dom_sf | 3 |
IPR023197 | 23,197 | Bacteriophage T4, Gp59, helicase assembly protein domain superfamily | Phage_T4_Gp59_dom_sf | Homologous_superfamily | 595 | false | false | The Bacteriophage T4 gene 59 helicase assembly protein (Gp59) is required for recombination-dependent DNA replication and repair, which is the predominant mode of DNA replication in the late stage of T4 infection. Gp59 accelerates the loading of the T4 gene 41 helicase during DNA synthesis by the T4 replication system ... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF48493"
] | [
""
] | [
595
] | 1 | [] | [] | [] | 0 | [
"1c1k"
] | 1 | [
"PUB00010626",
"PUB00097909"
] | [
"10669611",
"22427673"
] | [
"Bacteriophage T4 gene 59 helicase assembly protein binds replication fork DNA. The 1.45 A resolution crystal structure reveals a novel alpha-helical two-domain fold.",
"Mutational analysis of the T4 gp59 helicase loader reveals its sites for interaction with helicase, single-stranded binding protein, and DNA."
] | [
2000,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"Viruses",
"metagenomes"
] | [
4,
6,
549,
36
] | 4 | [] | [] | 0 | true | Homologous_superfamily | Bacteriophage T4, Gp59, helicase assembly protein domain superfamily | Bacteriophage T4, Gp59, helicase assembly protein domain superfamily | Phage_T4_Gp59_dom_sf | 4 |
IPR023198 | 23,198 | Phosphoglycolate phosphatase-like, domain 2 | PGP-like_dom2 | Homologous_superfamily | 182,738 | false | false | Phosphoglycolate phosphatase (PGP) is an essential enzyme in the glycolate salvage pathway in higher organisms (photorespiration in plants). Phosphoglycolate results from the oxidase activity of RubisCO in the Calvin cycle when concentrations of carbon dioxide are low relative to oxygen. In Ralstonia eutropha and Rhodo... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.150.240"
] | [
""
] | [
182738
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-73614",
"R-HSA-2142670",
"R-HSA-73614",
"R-HSA-77289",
"R-HSA-9018682",
"R-HSA-9033241",
"R-MMU-2142670",
"R-MMU-73614",
"R-MMU-77289",
"R-MMU-9018682",
"R-MMU-9033241",
"R-RNO-2142670",
"R-RNO-9018682",
"R-RNO-9033241",
"R-SCE-73614",
"R-SPO-73614",
"R-SSC-2142670",
"R-SSC-... | [
"REACTOME:R-DME-73614",
"REACTOME:R-HSA-2142670",
"REACTOME:R-HSA-73614",
"REACTOME:R-HSA-77289",
"REACTOME:R-HSA-9018682",
"REACTOME:R-HSA-9033241",
"REACTOME:R-MMU-2142670",
"REACTOME:R-MMU-73614",
"REACTOME:R-MMU-77289",
"REACTOME:R-MMU-9018682",
"REACTOME:R-MMU-9033241",
"REACTOME:R-RNO-21... | 19 | [
"1aq6",
"1cqz",
"1cr6",
"1ek1",
"1ek2",
"1fez",
"1jud",
"1lvh",
"1o03",
"1o08",
"1qh9",
"1qq5",
"1qq6",
"1qq7",
"1rdf",
"1rql",
"1rqn",
"1s8o",
"1swv",
"1sww",
"1te2",
"1vj5",
"1x42",
"1z4n",
"1z4o",
"1zd2",
"1zd3",
"1zd4",
"1zd5",
"1zol",
"1zrm",
"1zrn"... | 308 | [
"PUB00009585",
"PUB00009586"
] | [
"8226680",
"9006018"
] | [
"The cbb operons of the facultative chemoautotroph Alcaligenes eutrophus encode phosphoglycolate phosphatase.",
"Analysis of the cbbXYZ operon in Rhodobacter sphaeroides."
] | [
1993,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2470,
150961,
27215,
28,
2064
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
51,
5,
4,
15,
8,
12,
6,
5,
41,
13,
5,
2,
91
] | 13 | true | Homologous_superfamily | Phosphoglycolate phosphatase-like, domain 2 | Phosphoglycolate phosphatase-like, domain 2 | PGP-like_dom2 | 8 |
IPR023199 | 23,199 | Copper chaperone GriE/MELC1 superfamily | GriE/MELC1_sf | Homologous_superfamily | 1,084 | false | false | This superfamily represents the 2-layer α/β sandwich domain of tyrosinase co-factor MELC1 and copper chaperone GriE [ ]. The melanin operon (melC) of Streptomyces antibioticus contains two genes, melC1 and melC2 (apotyrosinase). It is thought that MelC1 forms a transient binary complex with the downstream apotyrosinase... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:3.30.1880.10"
] | [
""
] | [
1084
] | 1 | [] | [] | [] | 0 | [
"1wx2",
"1wx4",
"1wx5",
"1wxc",
"2ahk",
"2ahl",
"2jv8",
"2zmx",
"2zmy",
"2zmz",
"2zwd",
"2zwe",
"2zwf",
"2zwg",
"3aws",
"3awt",
"3awu",
"3awv",
"3aww",
"3awx",
"3awy",
"3awz",
"3ax0",
"5z0d",
"5z0e",
"5z0f",
"5z0g",
"5z0h",
"5z0i",
"5z0j",
"5z0k",
"5z0l"... | 36 | [
"PUB00012298",
"PUB00088139"
] | [
"8360164",
"16282322"
] | [
"Mutational study of Streptomyces tyrosinase trans-activator MelC1. MelC1 is likely a chaperone for apotyrosinase.",
"A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone."
] | [
1993,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"marine sediment metagenome"
] | [
3,
1080,
1
] | 3 | [] | [] | 0 | true | Homologous_superfamily | Copper chaperone GriE/MELC1 superfamily | Copper chaperone GriE/MELC1 superfamily | GriE/MELC1_sf | 4 |
IPR023200 | 23,200 | Ribosome modulation factor domain superfamily | RMF_sf | Homologous_superfamily | 2,964 | false | false | This superfamily represents the structural domain of ribosome modulation factors (RMF). They associate with 70s ribosomes and convert them to a dimeric form (100S ribosomes) which appear during the transition from the exponential growth phase to the stationary phase of Escherichia coli cells [ , ]. It has been proposed... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.10.620"
] | [
""
] | [
2964
] | 1 | [] | [] | [] | 0 | [
"2jrm",
"4v8g",
"6h4n",
"6h58",
"9iot"
] | 5 | [
"PUB00020259",
"PUB00020260",
"PUB00035842",
"PUB00035843"
] | [
"2181444",
"8440252",
"16088400",
"17185553"
] | [
"Structure and probable genetic location of a \"ribosome modulation factor\" associated with 100S ribosomes in stationary-phase Escherichia coli cells.",
"Regulation of the Escherichia coli rmf gene encoding the ribosome modulation factor: growth phase- and growth rate-dependent control.",
"The activity of ribo... | [
1990,
1993,
2005,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Halobaculum litoreum",
"metagenomes"
] | [
2930,
23,
1,
10
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Homologous_superfamily | Ribosome modulation factor domain superfamily | Ribosome modulation factor domain superfamily | RMF_sf | 3 |
IPR023201 | 23,201 | SecY domain superfamily | SecY_dom_sf | Homologous_superfamily | 41,741 | false | false | Secretion across the inner membrane in some Gram-negative bacteria occurs via the preprotein translocase pathway. Proteins are produced in the cytoplasm as precursors, and require a chaperone subunit to direct them to the translocase component [ ]. From there, the mature proteins are either targeted to the outer membra... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:1.10.3370.10",
"SSF103491"
] | [
"",
""
] | [
41573,
40912
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1222387",
"R-HSA-1236974",
"R-HSA-1799339",
"R-HSA-9760173"
] | [
"REACTOME:R-HSA-1222387",
"REACTOME:R-HSA-1236974",
"REACTOME:R-HSA-1799339",
"REACTOME:R-HSA-9760173"
] | 4 | [
"1rh5",
"1rhz",
"2akh",
"2aki",
"2ww9",
"2wwa",
"2wwb",
"2yxq",
"2yxr",
"2zjs",
"2zqp",
"3bo0",
"3bo1",
"3din",
"3dkn",
"3dl8",
"3j45",
"3j46",
"3j7q",
"3j7r",
"3jc2",
"3mp7",
"4cg5",
"4cg6",
"4cg7",
"4v4n",
"4v6m",
"4v7i",
"5a6u",
"5abb",
"5aww",
"5ch4"... | 96 | [
"PUB00000694",
"PUB00001631",
"PUB00003801",
"PUB00003823",
"PUB00007064",
"PUB00007065",
"PUB00007066",
"PUB00007187",
"PUB00022601"
] | [
"1764515",
"1544427",
"2110998",
"1406280",
"2202721",
"11336818",
"10418149",
"12167867",
"14661030"
] | [
"Presence of a gene in the archaebacterium Methanococcus vannielii homologous to secY of eubacteria.",
"A secY homologue is found in the plastid genome of Cryptomonas phi.",
"Isolation of a secY homologue from Bacillus subtilis: evidence for a common protein export pathway in eubacteria.",
"SecY and integral ... | [
1991,
1992,
1990,
1992,
1990,
2001,
1999,
2002,
2004
] | 9 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctHip2",
"unclassified sequences"
] | [
1083,
27299,
12621,
1,
737
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
21,
2,
3,
2,
1,
24,
7,
1,
35,
12,
2,
2,
38
] | 13 | true | Homologous_superfamily | SecY domain superfamily | SecY domain superfamily | SecY_dom_sf | 4 |
IPR023202 | 23,202 | YejL-like superfamily | YejL_sf | Homologous_superfamily | 1,934 | false | false | This superfamily represents the structural domain of the UPF0352 family of proteins, which have not known function. | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF158651"
] | [
""
] | [
1934
] | 1 | [] | [] | [] | 0 | [
"2jpq",
"2jr2",
"2jrx",
"2juw",
"2juz",
"2ota",
"2qti"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"marine sediment metagenome"
] | [
1932,
2
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Homologous_superfamily | YejL-like superfamily | YejL-like superfamily | YejL_sf | 4 |
IPR023203 | 23,203 | TTHA0068-like superfamily | TTHA0068_sf | Homologous_superfamily | 6,321 | false | false | This superfamily represents a structural domain found in the DUF309 family of proteins of unknown function. | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF140663"
] | [
""
] | [
6321
] | 1 | [] | [] | [] | 0 | [
"2cwy",
"2cxd",
"2ijq"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Pandoravirus japonicus",
"metagenomes"
] | [
817,
4932,
507,
1,
64
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
6,
5
] | 3 | true | Homologous_superfamily | TTHA0068-like superfamily | TTHA0068-like superfamily | TTHA0068_sf | 9 |
IPR023204 | 23,204 | SP1917 domain superfamily | SP1917_dom_sf | Homologous_superfamily | 3,890 | false | false | This superfamily represents the structural domain found in protein SP1917 and other members of the UCP033199 family of uncharacterised proteins. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.8.290"
] | [
""
] | [
3890
] | 1 | [] | [] | [] | 0 | [
"3c9p"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Haladaptatus pallidirubidus",
"Symbiodiniaceae",
"metagenomes"
] | [
3836,
1,
8,
45
] | 4 | [] | [] | 0 | true | Homologous_superfamily | SP1917 domain superfamily | SP1917 domain superfamily | SP1917_dom_sf | 9 |
IPR023205 | 23,205 | Thiol:disulphide interchange protein DsbA/DsbL | DsbA/DsbL | Family | 9,232 | false | false | Bacterial Disulfide bond forming (Dsb) proteins facilitate proper folding and disulfide bond formation of periplasmic and secreted proteins [ ]. Thiol:disulphide interchange proteins DsbA and DsbL are involved in disulfide-bond formation [ , ]. They act by transferring its disulfide bond to other proteins and are reduc... | [] | [] | [] | 0 | [
"PIRSF",
"CDD"
] | [
"PIRSF001488",
"cd03019"
] | [
"Tdi_protein",
"DsbA_DsbA"
] | [
7856,
9183
] | 2 | [
"REACTOME"
] | [
"R-HSA-9760173"
] | [
"REACTOME:R-HSA-9760173"
] | 1 | [
"1a23",
"1a24",
"1a2j",
"1a2l",
"1a2m",
"1ac1",
"1acv",
"1bed",
"1bq7",
"1dsb",
"1fvj",
"1fvk",
"1ti1",
"1u3a",
"1un2",
"2b3s",
"2b6m",
"2hi7",
"2ijy",
"2leg",
"2mbs",
"2mbt",
"2ndo",
"2rem",
"2znm",
"2zup",
"3a3t",
"3c7m",
"3dks",
"3dvw",
"3dvx",
"3e9j"... | 267 | [
"PUB00014003",
"PUB00050921",
"PUB00068800",
"PUB00068801",
"PUB00080831",
"PUB00080832",
"PUB00080833",
"PUB00080835"
] | [
"12524212",
"18565543",
"21241169",
"18082634",
"11967064",
"15546661",
"14739460",
"9099998"
] | [
"Protein disulfide bond formation in prokaryotes.",
"DsbL and DsbI form a specific dithiol oxidase system for periplasmic arylsulfate sulfotransferase in uropathogenic Escherichia coli.",
"Structure and function of DsbA, a key bacterial oxidative folding catalyst.",
"Structure and mechanisms of the DsbB-DsbA ... | [
2003,
2008,
2011,
2008,
2002,
2004,
2004,
1997
] | 8 | [] | [
"IPR028588"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
9109,
20,
103
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Thiol:disulphide interchange protein DsbA/DsbL | Thiol:disulphide interchange protein DsbA/DsbL | DsbA/DsbL | 1 |
IPR023206 | 23,206 | Bifunctional cytochrome P450/NADPH--cytochrome P450 reductase | Bifunctional_P450_P450_red | Family | 3,824 | false | false | Bifunctional cytochrome P450/NADPH--cytochrome P450 reductase (also known as P450foxy) is a fused protein of cytochrome P450 and its reductase [ ]. It is a fatty acid (FA) monooxygenase that is characterised by self-sufficient catalysis and high turnover numbers due to the fused structure [ ]. Its reductase domain is r... | [
"GO:0003958",
"GO:0070330"
] | [
"NADPH-hemoprotein reductase activity",
"aromatase activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PIRSF"
] | [
"PIRSF000209"
] | [
"Bifunctional_P450_P450R"
] | [
3824
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.14.14.1",
"1.6.2.4",
"PWY-5451",
"PWY-5665",
"PWY-6398",
"PWY-6992",
"PWY-7466"
] | [
"EC:1.14.14.1",
"EC:1.6.2.4",
"METACYC:PWY-5451",
"METACYC:PWY-5665",
"METACYC:PWY-6398",
"METACYC:PWY-6992",
"METACYC:PWY-7466"
] | 7 | [
"8dme",
"8dmg"
] | 2 | [
"PUB00076902",
"PUB00076903",
"PUB00076905"
] | [
"8830036",
"18512058",
"11985584"
] | [
"Cytochrome P450foxy, a catalytically self-sufficient fatty acid hydroxylase of the fungus Fusarium oxysporum.",
"Production of hydroxy-fatty acid derivatives from waste oil by Escherichia coli cells producing fungal cytochrome P450foxy.",
"Kinetic analysis of hydroxylation of saturated fatty acids by recombina... | [
1996,
2008,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater metagenome"
] | [
1650,
2173,
1
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Bifunctional cytochrome P450/NADPH--cytochrome P450 reductase | Bifunctional cytochrome P450/NADPH--cytochrome P450 reductase | Bifunctional_P450_P450_red | 4 |
IPR023208 | 23,208 | NADPH-cytochrome P450 reductase | P450R | Family | 6,185 | false | false | This group represents the NADPH--cytochrome P450 reductase (CPR) from eukaryotes. CPR is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5 [ , ]. Interestingly, animals harbour a single CPR gene, while higher plants have ... | [
"GO:0003958"
] | [
"NADPH-hemoprotein reductase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"PIRSF"
] | [
"MF_03212",
"PIRSF000208"
] | [
"NCPR",
"P450R"
] | [
5218,
5882
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"1.6.2.4",
"R-DDI-1222556",
"R-DDI-1474151",
"R-DDI-203615",
"R-DDI-203754",
"R-DDI-392154",
"R-DDI-5218920",
"R-DDI-5578775",
"R-DDI-9009391",
"R-DDI-9033241",
"R-DDI-9856530",
"R-HSA-211897",
"R-SCE-1222556",
"R-SCE-1474151",
"R-SCE-203615",
"R-SCE-392154",
"R-SCE-5218920",
"R-SC... | [
"EC:1.6.2.4",
"REACTOME:R-DDI-1222556",
"REACTOME:R-DDI-1474151",
"REACTOME:R-DDI-203615",
"REACTOME:R-DDI-203754",
"REACTOME:R-DDI-392154",
"REACTOME:R-DDI-5218920",
"REACTOME:R-DDI-5578775",
"REACTOME:R-DDI-9009391",
"REACTOME:R-DDI-9033241",
"REACTOME:R-DDI-9856530",
"REACTOME:R-HSA-211897"... | 30 | [
"1amo",
"1j9z",
"1ja0",
"1ja1",
"2bf4",
"2bn4",
"2bpo",
"3es9",
"3fjo",
"3ojw",
"3ojx",
"3qe2",
"3qfc",
"3qfr",
"3wkt",
"4y7c",
"4y9r",
"4y9u",
"4yaf",
"4yal",
"4yao",
"4yau",
"4yaw",
"5emn",
"5fa6",
"5gxu",
"5urd",
"5ure",
"5urg",
"5urh",
"5uri",
"6j79"... | 42 | [
"PUB00054029",
"PUB00054030",
"PUB00095602",
"PUB00095603"
] | [
"7646819",
"11594739",
"23053415",
"19931102"
] | [
"Cloning and characterization of the NADPH cytochrome P450 oxidoreductase gene from the filamentous fungus Aspergillus niger.",
"Purification and characterization of benzoate-para-hydroxylase, a cytochrome P450 (CYP53A1), from Aspergillus niger.",
"Rice P450 reductases differentially affect P450-mediated metabo... | [
1995,
2001,
2013,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6185
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
1,
5,
3,
10,
2,
1,
5,
3,
1,
1,
15
] | 12 | true | Family | NADPH-cytochrome P450 reductase | NADPH-cytochrome P450 reductase | P450R | 8 |
IPR023209 | 23,209 | D-amino-acid oxidase | DAO | Family | 14,768 | false | false | D-Amino acid oxidase (DAO or DAAO) is a flavin adenine dinucleotide (FAD)-containing flavoproteins that catalyse the oxidative deamination of d-amino acids with oxygen to generate the corresponding 2-oxo acids along with hydrogen peroxide and ammonia. It displays broad substrate specificity and acts on several neutral ... | [
"GO:0003884",
"GO:0071949",
"GO:0046416"
] | [
"D-amino-acid oxidase activity",
"FAD binding",
"D-amino acid metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF000189",
"PTHR11530"
] | [
"D-aa_oxidase",
""
] | [
9937,
14768
] | 2 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME"
] | [
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"PWY-5283",
"R-BTA-389661",
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"R-DDI-389661",
"R-DDI-9033241",
"R-HSA-389661",
"R-HSA-9033241",
"R-MMU-389661",
"R-MMU-9033241",
"R-RNO-389661",
"R-RNO-9033241",
"R-SPO-389661",
"R-SPO-9033241",
"R-SSC-389661",
"R-SSC-90332... | [
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"METACYC:PWY-5283",
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"REACTOME:R-BTA-9033241",
"REACTOME:R-CEL-389661",
"REACTOME:R-CEL-9033241",
"REACTOME:R-DDI-389661",
"REACTOME:R-DDI-9033241",
"REACTOME:R-HSA-389661",
"REACTOME:R-HSA-9033241",
"REACTOME:R-MMU-389661",
"REACTOME:R-MMU-9033241",
"RE... | 18 | [
"1an9",
"1c0i",
"1c0k",
"1c0l",
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"1dao",
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"3znq",
"4qfc",
"4qfd",
"4yjd",
"4yjf",
"4yjg",
"4yjh",
"5wwv"... | 42 | [
"PUB00074521"
] | [
"22393259"
] | [
"Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"metagenomes"
] | [
3988,
10706,
27,
47
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
5,
8,
5,
12,
9,
2,
9,
1,
1
] | 9 | true | Family | D-amino-acid oxidase | D-amino-acid oxidase | DAO | 4 |
IPR023210 | 23,210 | NADP-dependent oxidoreductase domain | NADP_OxRdtase_dom | Domain | 304,687 | false | false | The aldo-keto reductase family includes a number of related monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase, aldose reductase, prostaglandin F synthase, xylose reductase, rho crystallin, and many others [ ]. All possess a similar structure, with a β-α-β fold characteristic of nucleotide binding pr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00248"
] | [
"Aldo_ket_red"
] | [
304687
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"... | [
"1.1.1",
"GenProp1263",
"GenProp1551",
"GenProp1552",
"GenProp1649",
"R-BTA-1296072",
"R-BTA-156590",
"R-BTA-174403",
"R-BTA-193368",
"R-BTA-193775",
"R-BTA-193807",
"R-BTA-2162123",
"R-BTA-5365859",
"R-BTA-5661270",
"R-BTA-6798695",
"R-BTA-975634",
"R-BTA-9757110",
"R-DDI-156590",... | [
"EC:1.1.1",
"GP:GenProp1263",
"GP:GenProp1551",
"GP:GenProp1552",
"GP:GenProp1649",
"REACTOME:R-BTA-1296072",
"REACTOME:R-BTA-156590",
"REACTOME:R-BTA-174403",
"REACTOME:R-BTA-193368",
"REACTOME:R-BTA-193775",
"REACTOME:R-BTA-193807",
"REACTOME:R-BTA-2162123",
"REACTOME:R-BTA-5365859",
"RE... | 127 | [
"1a80",
"1abn",
"1ads",
"1ae4",
"1afs",
"1ah0",
"1ah3",
"1ah4",
"1az1",
"1az2",
"1c9w",
"1cwn",
"1dla",
"1ef3",
"1eko",
"1el3",
"1exb",
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"1gve",
"1hqt",
"1hw6",
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"1ihi",
"1j96",
"1jez",
"1k8c",
"1lqa",
"1lwi",
"1m9h",
"1mar",
"1mi3",
"1mrq"... | 506 | [
"PUB00002548",
"PUB00002605",
"PUB00002751",
"PUB00005156",
"PUB00015049"
] | [
"2498333",
"2105951",
"1447221",
"1621098",
"10884227"
] | [
"The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.",
"Sequence analysis of bovine lens aldose reductase.",
"The crystal structure of the aldose reductase.NADPH binary complex.",
"An unlikely sugar substrate site in the 1.65 A structure of the ... | [
1989,
1990,
1992,
1992,
2000
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5108,
188519,
108517,
24,
2519
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
113,
17,
62,
31,
9,
75,
78,
18,
105,
113,
16,
14,
194
] | 13 | true | Domain | NADP-dependent oxidoreductase domain | NADP-dependent oxidoreductase domain | NADP_OxRdtase_dom | 7 |
IPR023211 | 23,211 | DNA polymerase, palm domain superfamily | DNA_pol_palm_dom_sf | Homologous_superfamily | 43,479 | false | false | DNA is the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most important events in the life cycle of a cell. This function is performed by DNA- directed DNA-polymerases ) by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growi... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:3.90.1600.10"
] | [
""
] | [
43479
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.7.7",
"R-CEL-110314",
"R-CEL-5651801",
"R-CEL-5656169",
"R-CEL-5696397",
"R-CEL-5696400",
"R-CEL-6782135",
"R-CEL-6782210",
"R-CEL-69091",
"R-CEL-69166",
"R-CEL-69183",
"R-DDI-110314",
"R-DDI-113501",
"R-DDI-5651801",
"R-DDI-5656169",
"R-DDI-5696397",
"R-DDI-6782135",
"R-DDI-6... | [
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"REACTOME:R-CEL-110314",
"REACTOME:R-CEL-5651801",
"REACTOME:R-CEL-5656169",
"REACTOME:R-CEL-5696397",
"REACTOME:R-CEL-5696400",
"REACTOME:R-CEL-6782135",
"REACTOME:R-CEL-6782210",
"REACTOME:R-CEL-69091",
"REACTOME:R-CEL-69166",
"REACTOME:R-CEL-69183",
"REACTOME:R-DDI-110314",
... | 141 | [
"1clq",
"1d5a",
"1ig9",
"1ih7",
"1q8i",
"1q9x",
"1q9y",
"1qht",
"1qqc",
"1s5j",
"1tgo",
"1waf",
"1waj",
"1wn7",
"1wns",
"1xhx",
"1xhz",
"1xi1",
"2atq",
"2dtu",
"2dy4",
"2ex3",
"2gv9",
"2jgu",
"2oyq",
"2ozm",
"2ozs",
"2p5g",
"2p5o",
"2py5",
"2pyj",
"2pyl"... | 357 | [
"PUB00000436",
"PUB00010600",
"PUB00036457",
"PUB00097416",
"PUB00097417"
] | [
"8679562",
"9757117",
"7516581",
"19718023",
"23940661"
] | [
"Crystal structures of an NH2-terminal fragment of T4 DNA polymerase and its complexes with single-stranded DNA and with divalent metal ions.",
"Crystallization and preliminary diffraction analysis of a hyperthermostable DNA polymerase from a Thermococcus archaeon.",
"Crystal structure of rat DNA polymerase bet... | [
1996,
1998,
1994,
2009,
2013
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1757,
5215,
28270,
7423,
814
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
32,
7,
7,
7,
1,
34,
12,
4,
9,
22,
4,
4,
49
] | 13 | true | Homologous_superfamily | DNA polymerase, palm domain superfamily | DNA polymerase, palm domain superfamily | DNA_pol_palm_dom_sf | 1 |
IPR023212 | 23,212 | Heat shock protein Hsp33, helix hairpin bin domain superfamily | Hsp33_helix_hairpin_bin_dom_sf | Homologous_superfamily | 8,870 | false | false | Hsp33 is a molecular chaperone, distinguished from all other known chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localized protein with highly reactive cysteines that respond quickly to changes in the redox environment. Oxidizing conditions like H 2 O 2 cau... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.287.480"
] | [
""
] | [
8870
] | 1 | [] | [] | [] | 0 | [
"1hw7",
"1i7f",
"3m7m"
] | 3 | [
"PUB00000967",
"PUB00019723",
"PUB00036944",
"PUB00079556",
"PUB00079557"
] | [
"10025400",
"11377197",
"11323724",
"10102262",
"10359689"
] | [
"Chaperone activity with a redox switch.",
"The 2.2 A crystal structure of Hsp33: a heat shock protein with redox-regulated chaperone activity.",
"Crystal structure of proteolytic fragments of the redox-sensitive Hsp33 with constitutive chaperone activity.",
"Bridge over troubled waters: sensing stress by dis... | [
1999,
2001,
2001,
1999,
1999
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8792,
11,
67
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Homologous_superfamily | Heat shock protein Hsp33, helix hairpin bin domain superfamily | Heat shock protein Hsp33, helix hairpin bin domain superfamily | Hsp33_helix_hairpin_bin_dom_sf | 1 |
IPR023213 | 23,213 | Chloramphenicol acetyltransferase-like domain superfamily | CAT-like_dom_sf | Homologous_superfamily | 290,470 | false | false | This superfamily represents a domain characteristic of trimeric enzymes with the active sites being located in between subunits, including chloramphenicol acetyltransferase. Chloramphenicol acetyltransferase (CAT) catalyses the acetyl-CoA dependent acetylation of chloramphenicol, resulting in the inactivation of the an... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:3.30.559.10"
] | [
""
] | [
290470
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.3.1",
"R-BTA-200425",
"R-BTA-204174",
"R-BTA-389887",
"R-BTA-5362517",
"R-BTA-70895",
"R-BTA-9013407",
"R-BTA-9033241",
"R-BTA-9837999",
"R-BTA-9857492",
"R-BTA-9859138",
"R-BTA-9861559",
"R-CEL-1483191",
"R-CEL-204174",
"R-CEL-264642",
"R-CEL-5362517",
"R-CEL-9013407",
"R-CEL-9... | [
"EC:2.3.1",
"REACTOME:R-BTA-200425",
"REACTOME:R-BTA-204174",
"REACTOME:R-BTA-389887",
"REACTOME:R-BTA-5362517",
"REACTOME:R-BTA-70895",
"REACTOME:R-BTA-9013407",
"REACTOME:R-BTA-9033241",
"REACTOME:R-BTA-9837999",
"REACTOME:R-BTA-9857492",
"REACTOME:R-BTA-9859138",
"REACTOME:R-BTA-9861559",
... | 97 | [
"1b5s",
"1c4t",
"1cia",
"1cla",
"1dpb",
"1dpc",
"1dpd",
"1e2o",
"1eaa",
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"1eac",
"1ead",
"1eae",
"1eaf",
"1l5a",
"1ndb",
"1ndf",
"1ndi",
"1nm8",
"1noc",
"1pd5",
"1q23",
"1q6x",
"1q9j",
"1qca",
"1s5o",
"1scz",
"1t1u",
"1t7n",
"1t7o",
"1t7q",
"1xl7"... | 262 | [
"PUB00006247"
] | [
"2187098"
] | [
"Refined crystal structure of type III chloramphenicol acetyltransferase at 1.75 A resolution."
] | [
1990
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Plasmid pSBK203",
"Viruses",
"unclassified sequences"
] | [
908,
155049,
133006,
1,
15,
1491
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
382,
21,
44,
32,
3,
65,
28,
15,
465,
50,
6,
3,
401
] | 13 | true | Homologous_superfamily | Chloramphenicol acetyltransferase-like domain superfamily | Chloramphenicol acetyltransferase-like domain superfamily | CAT-like_dom_sf | 6 |
IPR023214 | 23,214 | HAD superfamily | HAD_sf | Homologous_superfamily | 957,472 | false | false | The haloacid dehydrogenase (HAD) superfamily includes phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification [ ]. Crystal structures of proteins from the ... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:3.40.50.1000"
] | [
""
] | [
957472
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1237112",
"R-BTA-1483206",
"R-BTA-2161541",
"R-BTA-4085001",
"R-BTA-418359",
"R-BTA-4419969",
"R-BTA-446205",
"R-BTA-5578775",
"R-BTA-71737",
"R-BTA-74259",
"R-BTA-936837",
"R-BTA-9755088",
"R-BTA-977347",
"R-CEL-112382",
"R-CEL-113418",
"R-CEL-1237112",
"R-CEL-418359",
"R-C... | [
"REACTOME:R-BTA-1237112",
"REACTOME:R-BTA-1483206",
"REACTOME:R-BTA-2161541",
"REACTOME:R-BTA-4085001",
"REACTOME:R-BTA-418359",
"REACTOME:R-BTA-4419969",
"REACTOME:R-BTA-446205",
"REACTOME:R-BTA-5578775",
"REACTOME:R-BTA-71737",
"REACTOME:R-BTA-74259",
"REACTOME:R-BTA-936837",
"REACTOME:R-BTA... | 208 | [
"1aq6",
"1cqz",
"1cr6",
"1ek1",
"1ek2",
"1f5s",
"1fez",
"1iwo",
"1j8d",
"1j97",
"1jud",
"1k1e",
"1kju",
"1kyt",
"1l6r",
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"1mh9",
"1mhs",
"1n8n",
"1n9k",
"1nf2",
"1nnl",
"1nrw",
"1o03",
"1o08"... | 1,203 | [
"PUB00003337",
"PUB00026943"
] | [
"7966317",
"14555659"
] | [
"Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.",
"Structure- and function-based characterization of a new phosphoglycolate phosphatase from Thermoplasma acidophilum."
] | [
1994,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
13851,
562211,
369134,
3344,
8932
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
738,
95,
292,
180,
29,
340,
235,
51,
546,
355,
42,
40,
1358
] | 13 | true | Homologous_superfamily | HAD superfamily | HAD superfamily | HAD_sf | 5 |
IPR023216 | 23,216 | Transcription regulator SKI/SnoN | Tscrpt_reg_SKI_SnoN | Family | 5,217 | false | false | This entry represents the SKI/SnoN family of proteins, which are the products of the oncogenic sno gene. This gene was identified based on its homology to v-ski , the transforming component of the Sloan-Kettering virus. Both Ski and SnoN are potent negative regulators of TGF-beta [ ]. Overexpression of Ski or SnoN resu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10005"
] | [
""
] | [
5217
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-201451",
"R-HSA-2173795",
"R-MMU-201451",
"R-MMU-2173795"
] | [
"REACTOME:R-HSA-201451",
"REACTOME:R-HSA-2173795",
"REACTOME:R-MMU-201451",
"REACTOME:R-MMU-2173795"
] | 4 | [
"1mr1",
"1sbx",
"3eq5",
"5c4v"
] | 4 | [
"PUB00013959",
"PUB00035365",
"PUB00054069",
"PUB00054070",
"PUB00054071",
"PUB00097260"
] | [
"12419246",
"15107821",
"19745809",
"19114989",
"15108807",
"29892481"
] | [
"Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling.",
"c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements.",
"SnoN functions as a tumour suppressor by inducing p... | [
2002,
2004,
2009,
2009,
2004,
2018
] | 6 | [] | [] | 0 | 0 | null | [
"Avian erythroblastosis virus (strain Sloan-Kettering)",
"Eumetazoa"
] | [
1,
5216
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
35,
10,
9,
15,
12
] | 6 | true | Family | Transcription regulator SKI/SnoN | Transcription regulator SKI/SnoN | Tscrpt_reg_SKI_SnoN | 1 |
IPR023219 | 23,219 | Hepatocyte nuclear factor 1, N-terminal domain superfamily | HNF1_dimer_N_dom_sf | Homologous_superfamily | 2,145 | false | false | The N-terminal dimerisation domain of the transcriptional activator hepatocyte nuclear factor 1 is essential for DNA binding and association of the transcriptional coactivator, DCoH (dimerization cofactor of HNF-1). This domain forms a unique four-helical bundle which is largely conserved when dimerisation occurs [ ]. | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF100957"
] | [
""
] | [
2145
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-210744",
"R-HSA-210745",
"R-HSA-210747",
"R-HSA-9831926",
"R-HSA-9925561",
"R-HSA-9925563",
"R-HSA-9937080"
] | [
"REACTOME:R-HSA-210744",
"REACTOME:R-HSA-210745",
"REACTOME:R-HSA-210747",
"REACTOME:R-HSA-9831926",
"REACTOME:R-HSA-9925561",
"REACTOME:R-HSA-9925563",
"REACTOME:R-HSA-9937080"
] | 7 | [
"1f93",
"1g2y",
"1g2z",
"1g39",
"1jb6",
"2gyp"
] | 6 | [
"PUB00014014"
] | [
"11106484"
] | [
"High-resolution structure of the HNF-1alpha dimerization domain."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2145
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
27,
6,
5
] | 4 | true | Homologous_superfamily | Hepatocyte nuclear factor 1, N-terminal domain superfamily | Hepatocyte nuclear factor 1, N-terminal domain superfamily | HNF1_dimer_N_dom_sf | 1 |
IPR023220 | 23,220 | Type IV secretion system VirB5 superfamily | T4SS_VirB5_sf | Homologous_superfamily | 3,904 | false | false | VirB5 proteins are an essential component of most type IV secretion systems. VirB5/TraC is a single domain protein consisting of a three helix bundle and a loose globular appendage [ ]. Structural and functional studies indicate that VirB5 proteins participate in protein-protein interactions important for pilus assembl... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.20.58.430"
] | [
""
] | [
3904
] | 1 | [] | [] | [] | 0 | [
"1r8i",
"7o3v",
"8rt9",
"8rtd"
] | 4 | [
"PUB00020399"
] | [
"14673074"
] | [
"Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3860,
24,
20
] | 3 | [] | [] | 0 | true | Homologous_superfamily | Type IV secretion system VirB5 superfamily | Type IV secretion system VirB5 superfamily | T4SS_VirB5_sf | 3 |
IPR023222 | 23,222 | PsbQ-like domain superfamily | PsbQ-like_dom_sf | Homologous_superfamily | 5,402 | false | false | This superfamily represents a four helix up-down bundle domain found in a number of proteins including PsbQ from chloroplast and cyanobacterial photosystem II, and cyclocphilins involved in the assembly and maintenanace of phtosystem II [ , , ]. | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:1.20.120.290",
"SSF101112"
] | [
"",
""
] | [
5332,
4418
] | 2 | [] | [] | [] | 0 | [
"1nze",
"1vyk",
"2mwq",
"3jcu",
"3ls0",
"3ls1",
"3rfy",
"3zsu",
"4yuu",
"5xnl",
"6j3y",
"6j3z",
"6j40",
"6jlu",
"6kac",
"7a73",
"7eu3",
"7f9o",
"7n8o",
"7rcv",
"7vd5",
"7wff",
"7wg5",
"7y5e",
"7y7a",
"8bd3",
"8iwh",
"8j5k",
"8tow",
"8wql",
"8xr6",
"8z9d"... | 36 | [
"PUB00046776",
"PUB00054073",
"PUB00054074"
] | [
"15982665",
"20210304",
"17909185"
] | [
"The 1.49 A resolution crystal structure of PsbQ from photosystem II of Spinacia oleracea reveals a PPII structure in the N-terminal region.",
"Crystal structure of PsbQ from Synechocystis sp. PCC 6803 at 1.8 A: implications for binding and function in cyanobacterial photosystem II.",
"A chloroplast cyclophilin... | [
2005,
2010,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
710,
4690,
2
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
25,
25,
54
] | 3 | true | Homologous_superfamily | PsbQ-like domain superfamily | PsbQ-like domain superfamily | PsbQ-like_dom_sf | 4 |
IPR023224 | 23,224 | Salmonella invasion protein A, C-terminal actin-binding domain superfamily | SipA_actin-bd_C_sf | Homologous_superfamily | 756 | false | false | Salmonella invasion protein A (SipA) is a virulence factor that is translocated into host cells by a type III secretion system. In the host cell it binds to actin, stimulates actin polymerisation and counteracts F-actin destabilising proteins. This contributes towards cytoskeletal rearrangements that allow the entry of... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:1.10.4110.10",
"SSF101312"
] | [
"",
""
] | [
755,
738
] | 2 | [] | [] | [] | 0 | [
"1q5z",
"8c4c",
"8c4e",
"8uee",
"8vfm"
] | 5 | [
"PUB00030139",
"PUB00054077",
"PUB00163366"
] | [
"14512630",
"11331579",
"25486861"
] | [
"Salmonella SipA polymerizes actin by stapling filaments with nonglobular protein arms.",
"Cooperation between actin-binding proteins of invasive Salmonella: SipA potentiates SipC nucleation and bundling of actin.",
"PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation."
... | [
2003,
2001,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
756
] | 1 | [] | [] | 0 | true | Homologous_superfamily | Salmonella invasion protein A, C-terminal actin-binding domain superfamily | Salmonella invasion protein A, C-terminal actin-binding domain superfamily | SipA_actin-bd_C_sf | 6 |
IPR023225 | 23,225 | Salmonella invasion protein A, chaperone-binding | SipA_chaperone-bd | Homologous_superfamily | 790 | false | false | Salmonella invasion protein A (SipA) is a virulence factor that is translocated into host cells by a type III secretion system. In the host cell it binds to actin, stimulates actin polymerisation and counteracts F-actin destabilising proteins. This contributes towards cytoskeletal rearrangements that allow the entry of... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:1.10.4150.10",
"SSF140746"
] | [
"",
""
] | [
786,
785
] | 2 | [] | [] | [] | 0 | [
"2fm8",
"2fm9",
"8vfm"
] | 3 | [
"PUB00035463",
"PUB00054077",
"PUB00163366"
] | [
"16507363",
"11331579",
"25486861"
] | [
"A common structural motif in the binding of virulence factors to bacterial secretion chaperones.",
"Cooperation between actin-binding proteins of invasive Salmonella: SipA potentiates SipC nucleation and bundling of actin.",
"PERP, a host tetraspanning membrane protein, is required for Salmonella-induced infla... | [
2006,
2001,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta"
] | [
788,
2
] | 2 | [] | [] | 0 | true | Homologous_superfamily | Salmonella invasion protein A, chaperone-binding | Salmonella invasion protein A, chaperone-binding | SipA_chaperone-bd | 8 |
IPR023226 | 23,226 | Glycoside hydrolase, family 49, N-terminal domain | Glyco_hydro_49_N_dom | Domain | 437 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [
"GO:0004553"
] | [
"hydrolase activity, hydrolyzing O-glycosyl compounds"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF17433"
] | [
"Glyco_hydro_49N"
] | [
437
] | 1 | [
"EC"
] | [
"3.2.1.11"
] | [
"EC:3.2.1.11"
] | 1 | [
"1ogm",
"1ogo",
"1wmr",
"1x0c",
"2z8g",
"3wwg",
"6nzs"
] | 7 | [
"PUB00004870",
"PUB00005266",
"PUB00029429",
"PUB00046823"
] | [
"7624375",
"8535779",
"12962629",
"18155243"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases.",
"Dextranase from Penicillium minioluteum: reaction course, crystal structure, and product complex.",
"Crystal structure of Aspergillus niger is... | [
1995,
1995,
2003,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
115,
322
] | 2 | [] | [] | 0 | true | Domain | Glycoside hydrolase, family 49, N-terminal domain | Glycoside hydrolase, family 49, N-terminal domain | Glyco_hydro_49_N_dom | 8 |
IPR023227 | 23,227 | S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal domain superfamily | SAM_OH_AdoTrfase_C_sf | Homologous_superfamily | 6,597 | false | false | The S-adenosyl-L-methionine (SAM) hydroxide adenosyltransferase family groups several fluorinase and chlorinase enzymes whose common feature is that they mediate nucleophilic reactions of their respective halide ions to the C-5' carbon of SAM [ ]. These enzymes utilise a rigorously conserved amino acid side chain triad... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:2.40.30.90",
"SSF101852"
] | [
"",
""
] | [
6586,
6458
] | 2 | [] | [] | [] | 0 | [
"1rqp",
"1rqr",
"1wu8",
"2c2w",
"2c4t",
"2c4u",
"2c5b",
"2c5h",
"2cbx",
"2cc2",
"2cw5",
"2f4n",
"2q6i",
"2q6k",
"2q6l",
"2q6o",
"2v7t",
"2v7u",
"2v7v",
"2v7w",
"2v7x",
"2wr8",
"2zbu",
"2zbv",
"4cqj",
"5b6i",
"5fiu",
"5lmz",
"6ryz",
"6rz2",
"7ccg",
"7xto"... | 32 | [
"PUB00030772",
"PUB00048880",
"PUB00054078",
"PUB00101218",
"PUB00151506"
] | [
"14765200",
"18059261",
"18675376",
"32776704",
"36996195"
] | [
"Crystal structure and mechanism of a bacterial fluorinating enzyme.",
"Discovery and characterization of a marine bacterial SAM-dependent chlorinase.",
"The fluorinase, the chlorinase and the duf-62 enzymes.",
"An Enzyme Containing the Conserved Domain of Unknown Function DUF62 Acts as a Stereoselective (R<s... | [
2004,
2008,
2008,
2020,
2023
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
670,
5688,
33,
205,
1
] | 5 | [] | [] | 0 | true | Homologous_superfamily | S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal domain superfamily | S-adenosyl-l-methionine hydroxide adenosyltransferase, C-terminal domain superfamily | SAM_OH_AdoTrfase_C_sf | 4 |
IPR023228 | 23,228 | S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal domain superfamily | SAM_OH_AdoTrfase_N_sf | Homologous_superfamily | 6,441 | false | false | The S-adenosyl-L-methionine (SAM) hydroxide adenosyltransferase family groups several fluorinase and chlorinase enzymes whose common feature is that they mediate nucleophilic reactions of their respective halide ions to the C-5' carbon of SAM [ ]. These enzymes utilise a rigorously conserved amino acid side chain triad... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:3.40.50.10790",
"SSF102522"
] | [
"",
""
] | [
6354,
6430
] | 2 | [] | [] | [] | 0 | [
"1rqp",
"1rqr",
"1wu8",
"2c2w",
"2c4t",
"2c4u",
"2c5b",
"2c5h",
"2cbx",
"2cc2",
"2cw5",
"2f4n",
"2q6i",
"2q6k",
"2q6l",
"2q6o",
"2v7t",
"2v7u",
"2v7v",
"2v7w",
"2v7x",
"2wr8",
"2zbu",
"2zbv",
"4cqj",
"5b6i",
"5fiu",
"5lmz",
"6ryz",
"6rz2",
"7ccg",
"7xto"... | 32 | [
"PUB00030772",
"PUB00048880",
"PUB00054078",
"PUB00101218",
"PUB00151506"
] | [
"14765200",
"18059261",
"18675376",
"32776704",
"36996195"
] | [
"Crystal structure and mechanism of a bacterial fluorinating enzyme.",
"Discovery and characterization of a marine bacterial SAM-dependent chlorinase.",
"The fluorinase, the chlorinase and the duf-62 enzymes.",
"An Enzyme Containing the Conserved Domain of Unknown Function DUF62 Acts as a Stereoselective (R<s... | [
2004,
2008,
2008,
2020,
2023
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
667,
5542,
33,
199
] | 4 | [] | [] | 0 | true | Homologous_superfamily | S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal domain superfamily | S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal domain superfamily | SAM_OH_AdoTrfase_N_sf | 7 |
IPR023229 | 23,229 | Type II secretion system protein GspM, periplasmic domain superfamily | T2SS_M_periplasmic_sf | Homologous_superfamily | 3,717 | false | false | GspM is part of the inner membrane component of the type II secretion system (T2SS). It consists of a short cytosolic N-terminal domain, a transmembrane domain, and a C-terminal periplasmic domain. The precise function of this protein is unknown [ ]. However, though in Vibrio cholerae, the EpsM protein interacts with t... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF103054"
] | [
""
] | [
3717
] | 1 | [] | [] | [] | 0 | [
"1uv7",
"7ze0",
"8a9x",
"8ab1"
] | 4 | [
"PUB00010089",
"PUB00031911",
"PUB00094009"
] | [
"10322014",
"15081815",
"24223969"
] | [
"Direct interaction of the EpsL and EpsM proteins of the general secretion apparatus in Vibrio cholerae.",
"The crystal structure of the periplasmic domain of the type II secretion system protein EpsM from Vibrio cholerae: the simplest version of the ferredoxin fold.",
"Dynamic interplay between the periplasmic... | [
1999,
2004,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3654,
8,
55
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Homologous_superfamily | Type II secretion system protein GspM, periplasmic domain superfamily | Type II secretion system protein GspM, periplasmic domain superfamily | T2SS_M_periplasmic_sf | 7 |
IPR023230 | 23,230 | Glycoside hydrolase, family 2, conserved site | Glyco_hydro_2_CS | Conserved_site | 17,277 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00719"
] | [
"GLYCOSYL_HYDROL_F2_1"
] | [
17277
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.2.1.23",
"PWY-6807",
"R-HSA-2024101",
"R-HSA-2160916",
"R-HSA-2206292",
"R-HSA-6798695",
"R-HSA-9953080",
"R-MMU-2024101",
"R-MMU-2160916",
"R-MMU-6798695",
"R-RNO-2024101",
"R-RNO-2160916",
"R-RNO-6798695",
"R-SSC-2024101",
"R-SSC-2160916",
"R-SSC-6798695"
] | [
"EC:3.2.1.23",
"METACYC:PWY-6807",
"REACTOME:R-HSA-2024101",
"REACTOME:R-HSA-2160916",
"REACTOME:R-HSA-2206292",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9953080",
"REACTOME:R-MMU-2024101",
"REACTOME:R-MMU-2160916",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-2024101",
"REACTOME:R-RNO-2160916",... | 16 | [
"1bhg",
"1dp0",
"1f4a",
"1f4h",
"1hn1",
"1jyn",
"1jyv",
"1jyw",
"1jyx",
"1jz2",
"1jz3",
"1jz4",
"1jz5",
"1jz6",
"1jz7",
"1jz8",
"1px3",
"1px4",
"1yq2",
"3bga",
"3czj",
"3dec",
"3dym",
"3dyo",
"3dyp",
"3e1f",
"3hn3",
"3i3b",
"3i3d",
"3i3e",
"3iap",
"3iaq"... | 159 | [
"PUB00002709",
"PUB00004870",
"PUB00005266"
] | [
"1350782",
"7624375",
"8535779"
] | [
"Glu-537, not Glu-461, is the nucleophile in the active site of (lac Z) beta-galactosidase from Escherichia coli.",
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases."
] | [
1992,
1995,
1995
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Orthoherpesviridae",
"unclassified sequences"
] | [
44,
13383,
3722,
2,
126
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
1,
8,
4,
4,
2,
1,
3,
5,
13
] | 10 | true | Conserved_site | Glycoside hydrolase, family 2, conserved site | Glycoside hydrolase, family 2, conserved site | Glyco_hydro_2_CS | 3 |
IPR023231 | 23,231 | GSKIP domain superfamily | GSKIP_dom_sf | Homologous_superfamily | 8,466 | false | false | This superfamily represents the structural domain of GSK3-beta interaction protein (GSKIP), which binds to GSK3beta [ ]. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:3.30.2280.10",
"SSF103107"
] | [
"",
""
] | [
6143,
8439
] | 2 | [] | [] | [] | 0 | [
"1sgo",
"8j07"
] | 2 | [
"PUB00054079",
"PUB00064791",
"PUB00068099",
"PUB00068100"
] | [
"16981698",
"19638420",
"14617080",
"9601101"
] | [
"GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta.",
"Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin.",
"The genetic control of plant mitochondrial morphology and dynamics."... | [
2006,
2009,
2003,
1998
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lachnoanaerobaculum saburreum DSM 3986"
] | [
8465,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
15,
12,
12,
5,
11,
6,
1,
6,
7,
1,
1,
56
] | 12 | true | Homologous_superfamily | GSKIP domain superfamily | GSKIP domain superfamily | GSKIP_dom_sf | 5 |
IPR023232 | 23,232 | Glycoside hydrolase, family 2, active site | Glyco_hydro_2_AS | Active_site | 20,572 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00608"
] | [
"GLYCOSYL_HYDROL_F2_2"
] | [
20572
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.2.1.23",
"PWY-6807",
"R-HSA-2024101",
"R-HSA-2160916",
"R-HSA-2206292",
"R-HSA-6798695",
"R-HSA-9953080",
"R-MMU-2024101",
"R-MMU-2160916",
"R-MMU-6798695",
"R-RNO-2024101",
"R-RNO-2160916",
"R-RNO-6798695",
"R-SSC-2024101",
"R-SSC-2160916",
"R-SSC-6798695"
] | [
"EC:3.2.1.23",
"METACYC:PWY-6807",
"REACTOME:R-HSA-2024101",
"REACTOME:R-HSA-2160916",
"REACTOME:R-HSA-2206292",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9953080",
"REACTOME:R-MMU-2024101",
"REACTOME:R-MMU-2160916",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-2024101",
"REACTOME:R-RNO-2160916",... | 16 | [
"1bhg",
"1dp0",
"1f4a",
"1f4h",
"1hn1",
"1jyn",
"1jyv",
"1jyw",
"1jyx",
"1jz2",
"1jz3",
"1jz4",
"1jz5",
"1jz6",
"1jz7",
"1jz8",
"1px3",
"1px4",
"1yq2",
"3dym",
"3dyo",
"3dyp",
"3e1f",
"3gm8",
"3hn3",
"3i3b",
"3i3d",
"3i3e",
"3iap",
"3iaq",
"3j7h",
"3k46"... | 145 | [
"PUB00002709",
"PUB00004870",
"PUB00005266"
] | [
"1350782",
"7624375",
"8535779"
] | [
"Glu-537, not Glu-461, is the nucleophile in the active site of (lac Z) beta-galactosidase from Escherichia coli.",
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases."
] | [
1992,
1995,
1995
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Heunggongvirae",
"unclassified sequences"
] | [
60,
15364,
5030,
3,
115
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
14,
1,
7,
4,
4,
2,
1,
6,
5,
27
] | 10 | true | Active_site | Glycoside hydrolase, family 2, active site | Glycoside hydrolase, family 2, active site | Glyco_hydro_2_AS | 2 |
IPR023233 | 23,233 | Herpesvirus major capsid protein, upper domain superfamily | Herpes_MCP_upper_sf | Homologous_superfamily | 630 | false | false | The Herpesvirus major capsid protein (MCP) is the principal protein of the icosahedral capsid, forming the main component of the hexavalent and probably the pentavalent capsomeres. The capsid shell consists of 150 MCP hexamers and 12 MCP pentamers. One pentamer is found at each of the 12 apices of the icosahedral shell... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF103417"
] | [
""
] | [
630
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9609690",
"R-HSA-9610379"
] | [
"REACTOME:R-HSA-9609690",
"REACTOME:R-HSA-9610379"
] | 2 | [
"1no7",
"5vku",
"5zap",
"5zz8",
"6b43",
"6cgr",
"6lgl",
"6lgn",
"6m6g",
"6m6h",
"6m6i",
"6nhj",
"6odm",
"6ppb",
"6ppd",
"6pph",
"6q1f",
"6w19",
"6w2d",
"6w2e",
"7bqx",
"7br7",
"7br8",
"7bsi",
"7bw6",
"7et3",
"7etj",
"7eto",
"7fj1",
"7fj3",
"7liv",
"8hex"... | 46 | [
"PUB00019684",
"PUB00029159",
"PUB00054081",
"PUB00054082"
] | [
"11222712",
"12574112",
"7583656",
"10797014"
] | [
"Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus.",
"Structure of the herpesvirus major capsid protein.",
"Assembly of VP26 in herpes simplex virus-1 inferred... | [
2001,
2003,
1995,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Heimdallarchaeum aukensis",
"Eukaryota",
"Herpesvirales"
] | [
3,
1,
4,
622
] | 4 | [
"Homo sapiens"
] | [
1
] | 1 | true | Homologous_superfamily | Herpesvirus major capsid protein, upper domain superfamily | Herpesvirus major capsid protein, upper domain superfamily | Herpes_MCP_upper_sf | 7 |
IPR023234 | 23,234 | NarG-like domain | NarG-like_domain | Domain | 8,885 | false | false | The NarG-like domain was originally characterised in the molybdo-bis(molybdopterin guanine dinucleotide) (Mo-bisMGD) cofactor-binding subunit NarG from nitrate reductase subunit. It is also found in homologous subunits from other oxidorectuases such as the coenzymeB--coenzymeM heterodisulphide reductase subunit E. Stru... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02665"
] | [
"Nitrate_red_gam"
] | [
8885
] | 1 | [] | [] | [] | 0 | [
"1q16",
"1siw",
"1y4z",
"1y5i",
"1y5l",
"1y5n",
"3egw",
"3ir5",
"3ir6",
"3ir7"
] | 10 | [
"PUB00017049"
] | [
"12910261"
] | [
"Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
159,
8530,
4,
192
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | NarG-like domain | NarG-like domain | NarG-like_domain | 5 |
IPR023236 | 23,236 | Inactive ubiquitin thioesterase OTULINL | OTULINL | Family | 1,007 | false | false | An approximately 350-residue amino acid polypeptide, designated protein FAM105A (also known as OTULINL), has been identified in a range of vertebrates. It shares a high degree of similarity with protein FAM105B (also known as OTULIN), an ubiquitin thioesterase. Despite their similarity, FAM105A lacks the conserved acti... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02056"
] | [
"PROTEINF105A"
] | [
1007
] | 1 | [] | [] | [] | 0 | [
"6drm"
] | 1 | [
"PUB00076542"
] | [
"23708998"
] | [
"The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis."
] | [
2013
] | 1 | [
"IPR023235"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1007
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
1,
4,
8
] | 4 | true | Family | Inactive ubiquitin thioesterase OTULINL | Inactive ubiquitin thioesterase OTULINL | OTULINL | 3 |
IPR023237 | 23,237 | Ubiquitin thioesterase otulin | Otulin | Family | 826 | false | false | Otulin (also known as FAM105B) belongs to the ovarian tumour (OTU) deubiquitinases (DUBs) family [ ]. It specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response [ ]. It associates with the LUBAC complex via direct interaction wit... | [
"GO:0004843",
"GO:1990108"
] | [
"cysteine-type deubiquitinase activity",
"protein linear deubiquitination"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR02057"
] | [
"PROTEINF105B"
] | [
826
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5357905",
"R-HSA-8866652",
"R-MMU-8866652"
] | [
"REACTOME:R-HSA-5357905",
"REACTOME:R-HSA-8866652",
"REACTOME:R-MMU-8866652"
] | 3 | [
"3znv",
"3znx",
"3znz",
"4ksj",
"4ksk",
"4ksl",
"5oe7",
"6i9c",
"6sak"
] | 9 | [
"PUB00076542",
"PUB00076543",
"PUB00076544"
] | [
"23708998",
"23827681",
"23746843"
] | [
"The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.",
"OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.",
"OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin."
] | [
2013,
2013,
2013
] | 3 | [
"IPR023235"
] | [] | 1 | 0 | 1 | [
"Metazoa"
] | [
826
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
2
] | 3 | true | Family | Ubiquitin thioesterase otulin | Ubiquitin thioesterase otulin | Otulin | 3 |
IPR023238 | 23,238 | FAM175 family | FAM175 | Family | 3,157 | false | false | Members of protein family FAM175 include the BRCA1-A complex subunit Abraxas 1 [ , ], BRISC complex subunit Abraxas 2 or Abro1 (Abraxas brother protein 1) [ , ], and uncharacterised plant proteins. It is thought that BRCA1-A complex subunit Abraxas acts as a central scaffold protein responsible for assembling the vario... | [] | [] | [] | 0 | [
"PRINTS",
"PANTHER"
] | [
"PR02051",
"PTHR31728"
] | [
"PROTEINF175",
""
] | [
2813,
3128
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5689901",
"R-BTA-5693565",
"R-BTA-5693571",
"R-BTA-5693607",
"R-BTA-69473",
"R-HSA-5689901",
"R-HSA-5693565",
"R-HSA-5693571",
"R-HSA-5693607",
"R-HSA-69473",
"R-MMU-5689901",
"R-MMU-5693565",
"R-MMU-5693571",
"R-MMU-5693607",
"R-MMU-69473",
"R-RNO-5689901",
"R-RNO-5693565",
... | [
"REACTOME:R-BTA-5689901",
"REACTOME:R-BTA-5693565",
"REACTOME:R-BTA-5693571",
"REACTOME:R-BTA-5693607",
"REACTOME:R-BTA-69473",
"REACTOME:R-HSA-5689901",
"REACTOME:R-HSA-5693565",
"REACTOME:R-HSA-5693571",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-69473",
"REACTOME:R-MMU-5689901",
"REACTOME:R-... | 21 | [
"5cw3",
"5cw4",
"5cw5",
"6gvw",
"6h3c",
"6r8f",
"8pvy",
"8py2"
] | 8 | [
"PUB00054085",
"PUB00054086",
"PUB00054087",
"PUB00054088"
] | [
"17525340",
"18077395",
"19214193",
"19261749"
] | [
"Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.",
"Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.",
"K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal P... | [
2007,
2007,
2009,
2009
] | 4 | [] | [
"IPR023239",
"IPR023240",
"IPR023241"
] | 0 | 3 | 0 | [
"Eukaryota"
] | [
3157
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
3,
7,
7,
5,
13,
6
] | 7 | true | Family | FAM175 family | FAM175 family | FAM175 | 1 |
IPR023240 | 23,240 | BRISC complex, Abraxas 2 subunit | BRISC_Abraxas2 | Family | 1,035 | false | false | This entry represents the Abraxas 2 protein. Members of protein family FAM175 include the BRCA1-A complex subunit Abraxas 1 [ , ], BRISC complex subunit Abraxas 2 or Abro1 (Abraxas brother protein 1) [ , ], and uncharacterised plant proteins. It is thought that BRCA1-A complex subunit Abraxas acts as a central scaffold... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02053"
] | [
"BRISCABRO1"
] | [
1035
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5689901",
"R-MMU-5689901",
"R-XTR-5689901"
] | [
"REACTOME:R-HSA-5689901",
"REACTOME:R-MMU-5689901",
"REACTOME:R-XTR-5689901"
] | 3 | [
"6h3c",
"6r8f",
"8pvy",
"8py2"
] | 4 | [
"PUB00054085",
"PUB00054086",
"PUB00054087",
"PUB00054088"
] | [
"17525340",
"18077395",
"19214193",
"19261749"
] | [
"Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.",
"Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.",
"K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal P... | [
2007,
2007,
2009,
2009
] | 4 | [
"IPR023238"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1035
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
5,
7
] | 4 | true | Family | BRISC complex, Abraxas 2 subunit | BRISC complex, Abraxas 2 subunit | BRISC_Abraxas2 | 8 |
IPR023241 | 23,241 | FAM175 family, plant | FAM175_plant | Family | 472 | false | false | This entry represents the plant members of FAM175. Members of protein family FAM175 include the BRCA1-A complex subunit Abraxas 1 [ , ], BRISC complex subunit Abraxas 2 or Abro1 (Abraxas brother protein 1) [ , ], and uncharacterised plant proteins. It is thought that BRCA1-A complex subunit Abraxas acts as a central sc... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02054"
] | [
"FAM175PLANT"
] | [
472
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054085",
"PUB00054086",
"PUB00054087",
"PUB00054088"
] | [
"17525340",
"18077395",
"19214193",
"19261749"
] | [
"Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.",
"Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.",
"K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal P... | [
2007,
2007,
2009,
2009
] | 4 | [
"IPR023238"
] | [] | 1 | 0 | 1 | [
"Streptophyta"
] | [
472
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica"
] | [
4,
1
] | 2 | true | Family | FAM175 family, plant | FAM175 family, plant | FAM175_plant | 1 |
IPR023243 | 23,243 | FAM25 | FAM25 | Family | 227 | false | false | A small, approximately 90-residue amino acid polypeptide, designated protein FAM25, has been identified in human and mouse. Its function is currently unknown. | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF15825",
"PR02048",
"PTHR34994"
] | [
"FAM25",
"PROTEINF25",
""
] | [
223,
208,
206
] | 3 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
227
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
2
] | 3 | true | Family | FAM25 | FAM25 | FAM25 | 2 |
IPR023245 | 23,245 | FAM138 | FAM138 | Family | 18 | false | false | A number of genes are expressed exclusively in the retina, where they appear to control the specialised functions of various different cell types [ ]. One of these retinal genes (termed FAM138A/B/C/F) is found within a region of subtelomeric DNA and exhibits polymorphic distribution among multiple chromosomes [ ]. This... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02046"
] | [
"FAM138ABCDF"
] | [
18
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054089"
] | [
"11779631"
] | [
"Identification of a novel retina-specific gene located in a subtelomeric region with polymorphic distribution among multiple human chromosomes."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Boreoeutheria"
] | [
18
] | 1 | [] | [] | 0 | true | Family | FAM138 | FAM138 | FAM138 | 5 |
IPR023246 | 23,246 | Autism susceptibility gene 2 protein | AUTS2 | Family | 6,060 | false | false | AUTS2 is a novel gene identified in a monozygotic twin pair with autism; its translation product is a large protein containing 1,295 amino acids [ ]. Following DNA sequence analysis of autism subjects and controls, no autism-specific mutation was observed. Association and linkage analyses were also negative. It is henc... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF15336",
"PR02044",
"PTHR14429"
] | [
"Auts2",
"FIBROSIN1LPF",
""
] | [
5255,
4413,
5980
] | 3 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-8939243",
"R-MMU-8939243"
] | [
"REACTOME:R-HSA-8939243",
"REACTOME:R-MMU-8939243"
] | 2 | [] | 0 | [
"PUB00054090"
] | [
"12160723"
] | [
"Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Corynebacterium marinum",
"Eukaryota"
] | [
2,
6058
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
118,
23,
27,
15
] | 4 | true | Family | Autism susceptibility gene 2 protein | Autism susceptibility gene 2 protein | AUTS2 | 9 |
IPR023248 | 23,248 | Ubiquinol-cytochrome-c reductase complex assembly factor 4, vertebrates | UQCC4_vert | Family | 414 | false | false | This family represents the ubiquinol-cytochrome-c reductase complex assembly factor 4 (UQCC4) from vertebrates, a family of proteins that was discovered in a screen of Bos taurus placental ESTs. The B. taurus member of this family was named cattle cerebrum and skeletal muscle-specific transcript 1 (CCSMST1) [ ], hence ... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02042"
] | [
"CCSMST1"
] | [
414
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054093",
"PUB00103608"
] | [
"16554549",
"35977508"
] | [
"Discovery of eight novel divergent homologs expressed in cattle placenta.",
"Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis."
] | [
2006,
2022
] | 2 | [
"IPR029160"
] | [] | 1 | 0 | 1 | [
"Deuterostomia"
] | [
414
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
2
] | 4 | true | Family | Ubiquinol-cytochrome-c reductase complex assembly factor 4, vertebrates | Ubiquinol-cytochrome-c reductase complex assembly factor 4, vertebrates | UQCC4_vert | 9 |
IPR023250 | 23,250 | Cyclin-dependent kinase 2-interacting protein | Cyclin-dep_Kinase_2_interact | Family | 1,260 | false | false | Cyclin-dependent kinase 2-interacting protein (CINP) is a component of the active cyclin E/Cdk2 and cyclin A/Cdk2 complexes [ ]. It is phopshorylated by Cdc7, but not by Cdk2 [ ]. CINP has also been shown to bind to chromatin in a replication-dependent manner, and to associate with Origin Recognition Complex-2 (ORC2)-c... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02040"
] | [
"CDK2IP"
] | [
1260
] | 1 | [] | [] | [] | 0 | [
"8cih",
"8rhn",
"9gwj",
"9lgo"
] | 4 | [
"PUB00054095"
] | [
"16082200"
] | [
"A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1260
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
8,
7
] | 4 | true | Family | Cyclin-dependent kinase 2-interacting protein | Cyclin-dependent kinase 2-interacting protein | Cyclin-dep_Kinase_2_interact | 2 |
IPR023251 | 23,251 | Pre-mRNA-splicing factor Brr1 | Brr1 | Family | 175 | false | false | PRE-mRNA splicing is catalysed by the spliceosome, a large dynamic complex composed of five small nuclear RNAs (snRNAs) and more than 80 proteins. Brr1 (Bad Response to Refrigeration protein 1) is a component of spliceosomal snRNPs [ ]. Brr1 is a nuclear protein involved in mRNA splicing and required for snRNA accumula... | [
"GO:0030532"
] | [
"small nuclear ribonucleoprotein complex"
] | [
"cellular_component"
] | 1 | [
"PRINTS"
] | [
"PR02039"
] | [
"SPLICEFRBRR1"
] | [
175
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054096",
"PUB00054097",
"PUB00054098"
] | [
"8861964",
"8722763",
"15911574"
] | [
"Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs.",
"Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations.",
"Genetic analysis reveals a role for the C terminus of the Saccharomy... | [
1996,
1996,
2005
] | 3 | [
"IPR035426"
] | [] | 1 | 0 | 1 | [
"Fungi"
] | [
175
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Pre-mRNA-splicing factor Brr1 | Pre-mRNA-splicing factor Brr1 | Brr1 | 3 |
IPR023252 | 23,252 | Aurora borealis protein | Aurora_borealis_protein | Family | 1,847 | false | false | Aurora-A, a protein kinase required for centrosome maturation, spindle assembly and asymmetric protein localisation during mitosis, is activated by Aurora borealis protein at the onset of the mitotic cycle [ ]. Bora is a nuclear protein in interphase cells, but is excluded from the nucleus and translocates to the cytop... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF15280",
"PR02038",
"PTHR14728"
] | [
"BORA_N",
"AURORABORA",
""
] | [
1806,
1531,
1734
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-2565942",
"R-DME-69273",
"R-DRE-2565942",
"R-DRE-69273",
"R-HSA-2565942",
"R-HSA-69273",
"R-MMU-2565942",
"R-MMU-69273",
"R-RNO-2565942",
"R-RNO-69273"
] | [
"REACTOME:R-DME-2565942",
"REACTOME:R-DME-69273",
"REACTOME:R-DRE-2565942",
"REACTOME:R-DRE-69273",
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-69273",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-69273",
"REACTOME:R-RNO-2565942",
"REACTOME:R-RNO-69273"
] | 10 | [] | 0 | [
"PUB00054099"
] | [
"16890155"
] | [
"Mitotic activation of the kinase Aurora-A requires its binding partner Bora."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1847
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
1,
8,
2,
4
] | 6 | true | Family | Aurora borealis protein | Aurora borealis protein | Aurora_borealis_protein | 5 |
IPR023253 | 23,253 | FPRL1/chemotaxis inhibitory protein | FLIPR/CHIPS | Family | 55 | false | false | Formyl Peptide Receptor-Like 1 (FPRL1)-inhibitory protein (also termed FLIPr) has been shown to inhibit calcium mobilisation in neutrophils [ ]. There is evidence that FLIPr binds to FPRL1 and, at higher concentrations, to FPR [ ], impairing the leukocyte response to FPRL1 agonists. It has revealed unknown inflammatory... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02035"
] | [
"FLIPRCHIPS"
] | [
55
] | 1 | [] | [] | [] | 0 | [
"1xee",
"2k3u"
] | 2 | [
"PUB00038277",
"PUB00054100",
"PUB00054101"
] | [
"16213522",
"17114475",
"14993252"
] | [
"The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of Staphylococcus aureus is related to a group of immune evasive molecules.",
"A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1.",
"Chemotaxis inhibitory protein of Staphylococcu... | [
2005,
2006,
2004
] | 3 | [] | [
"IPR020986",
"IPR023256"
] | 0 | 2 | 0 | [
"Bronfenbrennervirinae",
"Staphylococcus"
] | [
9,
46
] | 2 | [] | [] | 0 | true | Family | FPRL1/chemotaxis inhibitory protein | FPRL1/chemotaxis inhibitory protein | FLIPR/CHIPS | 5 |
IPR023254 | 23,254 | Aquaporin 6 | Aquaporin_6 | Family | 297 | false | false | Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol [ ]. In higher eukaryotes these proteins play diverse roles... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02018"
] | [
"AQUAPORIN6"
] | [
297
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-GGA-432047",
"R-HSA-432047"
] | [
"REACTOME:R-GGA-432047",
"REACTOME:R-HSA-432047"
] | 2 | [] | 0 | [
"PUB00028718",
"PUB00031522",
"PUB00033222",
"PUB00033223",
"PUB00033224",
"PUB00043535",
"PUB00054102",
"PUB00054103",
"PUB00054104",
"PUB00054105",
"PUB00054106",
"PUB00083165"
] | [
"11780053",
"15377788",
"15340377",
"16406529",
"14691544",
"16650285",
"10318966",
"19811639",
"17318586",
"19096784",
"19336226",
"10872456"
] | [
"Structural basis of water-specific transport through the AQP1 water channel.",
"The channel architecture of aquaporin 0 at a 2.2-A resolution.",
"From structure to disease: the evolving tale of aquaporin biology.",
"Why do microorganisms have aquaporins?",
"Architecture and selectivity in aquaporins: 2.5 a... | [
2001,
2004,
2004,
2006,
2003,
2006,
1999,
2009,
2007,
2009,
2009,
1999
] | 12 | [
"IPR034294"
] | [] | 1 | 0 | 1 | [
"Amniota"
] | [
297
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
3
] | 3 | true | Family | Aquaporin 6 | Aquaporin 6 | Aquaporin_6 | 3 |
IPR023256 | 23,256 | FPRL1 inhibitory protein | FLIPR | Family | 34 | false | false | Formyl Peptide Receptor-Like 1 (FPRL1)-inhibitory protein (also termed FLIPr) has been shown to inhibit calcium mobilisation in neutrophils [ ]. There is evidence that FLIPr binds to FPRL1 and, at higher concentrations, to FPR [ ], impairing the leukocyte response to FPRL1 agonists. It has revealed unknown inflammatory... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS"
] | [
"PF16104",
"PR02037"
] | [
"FPRL1_inhibitor",
"FLIPR"
] | [
34,
33
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054100"
] | [
"17114475"
] | [
"A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1."
] | [
2006
] | 1 | [
"IPR023253"
] | [] | 1 | 0 | 1 | [
"Staphylococcus"
] | [
34
] | 1 | [] | [] | 0 | true | Family | FPRL1 inhibitory protein | FPRL1 inhibitory protein | FLIPR | 5 |
IPR023257 | 23,257 | Liver X receptor | Liver_X_rcpt | Family | 1,729 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [
"GO:0003677",
"GO:0004879",
"GO:0006629"
] | [
"DNA binding",
"nuclear receptor activity",
"lipid metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR02034"
] | [
"LIVERXRECPTR"
] | [
1729
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-383280",
"R-BTA-4090294",
"R-BTA-8866427",
"R-BTA-9029569",
"R-BTA-9623433",
"R-HSA-1989781",
"R-HSA-383280",
"R-HSA-4090294",
"R-HSA-8866427",
"R-HSA-9029558",
"R-HSA-9029569",
"R-HSA-9031525",
"R-HSA-9031528",
"R-HSA-9623433",
"R-HSA-9632974",
"R-MMU-383280",
"R-MMU-4090294"... | [
"REACTOME:R-BTA-383280",
"REACTOME:R-BTA-4090294",
"REACTOME:R-BTA-8866427",
"REACTOME:R-BTA-9029569",
"REACTOME:R-BTA-9623433",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-383280",
"REACTOME:R-HSA-4090294",
"REACTOME:R-HSA-8866427",
"REACTOME:R-HSA-9029558",
"REACTOME:R-HSA-9029569",
"REACTOME:... | 25 | [
"1p8d",
"1pq6",
"1pq9",
"1pqc",
"1uhl",
"1upv",
"1upw",
"2acl",
"3fal",
"3fc6",
"3ipq",
"3ips",
"3ipu",
"3kfc",
"3l0e",
"4dk7",
"4dk8",
"4nqa",
"4rak",
"5avi",
"5avl",
"5hjp",
"5hjs",
"5i4v",
"5jy3",
"5kya",
"5kyj",
"6jio",
"6k9g",
"6k9h",
"6k9m",
"6s4n"... | 35 | [
"PUB00004464",
"PUB00006168",
"PUB00015853",
"PUB00054108",
"PUB00054109"
] | [
"7899080",
"8165128",
"14747695",
"19436111",
"19837721"
] | [
"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
"Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
"Nuclear receptors: the evolution of diversity.",
"Liver X receptors contribute to the protective immune response against Mycoba... | [
1995,
1994,
2004,
2009,
2010
] | 5 | [
"IPR001723"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1729
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
26,
15,
12
] | 4 | true | Family | Liver X receptor | Liver X receptor | Liver_X_rcpt | 4 |
IPR023259 | 23,259 | Dexamethasone-induced protein | Dexamethasone-induced | Family | 619 | false | false | Dexamethasone is a member of the glucocorticoid group of steroid hormones; it functions as an anti-inflammatory and immunosuppressant. A differentially- expressed transcript of unknown function has been identified in emphysematous lungs [ ] - this has been named Dexamethasone-Induced transcript (DEXI). It is suggested ... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF15198",
"PR02032",
"PTHR17070"
] | [
"Dexa_ind",
"DEXMETHSNEIP",
""
] | [
619,
615,
616
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054111"
] | [
"11472984"
] | [
"Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
619
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
2
] | 4 | true | Family | Dexamethasone-induced protein | Dexamethasone-induced protein | Dexamethasone-induced | 6 |
IPR023260 | 23,260 | Cysteine/serine-rich nuclear protein family | Cys/Ser-rich_nuc_prot | Family | 4,054 | false | false | Members of the cysteine/serine-rich nuclear protein family (CSRNP) contain cysteine- and serine-rich regions and a basic domain. They are nuclear proteins that possess a transcriptional activation domain and bind the sequence AGAGTG [ , ]. The proteins actively influence transcriptional activity, but it has not been es... | [] | [] | [] | 0 | [
"PRINTS",
"PANTHER"
] | [
"PR02031",
"PTHR13580"
] | [
"CYSSERRICHNP",
""
] | [
3681,
4036
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054112",
"PUB00054113"
] | [
"17726538",
"18291095"
] | [
"Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP).",
"Taip2 is a novel cell death-related gene expressed in the brain during development."
] | [
2007,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4054
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
13,
1,
12,
7,
10
] | 6 | true | Family | Cysteine/serine-rich nuclear protein family | Cysteine/serine-rich nuclear protein family | Cys/Ser-rich_nuc_prot | 3 |
IPR023261 | 23,261 | Autophagy-related protein 14 | Autophagy-related_protein_14 | Family | 58 | false | false | Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells [ ]. In yeast, 15 autophagy (Apg) proteins coordinate the formation of autophagosomes. Apg14p and Vps30p/Apg6p, components of an autophagy-specific phosphatidylinositol 3-kinase complex, together with Apg9p and Apg16p, are required f... | [
"GO:0016236"
] | [
"macroautophagy"
] | [
"biological_process"
] | 1 | [
"PRINTS"
] | [
"PR02030"
] | [
"AUTOPHGYRP14"
] | [
58
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009839",
"PUB00009843",
"PUB00054114"
] | [
"11689437",
"9712845",
"11157979"
] | [
"The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.",
"Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.",
"Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in aut... | [
2001,
1998,
2001
] | 3 | [
"IPR018791"
] | [] | 1 | 0 | 1 | [
"Saccharomycetaceae"
] | [
58
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Autophagy-related protein 14 | Autophagy-related protein 14 | Autophagy-related_protein_14 | 8 |
IPR023264 | 23,264 | ABC transporter, acetoin utilisation, predicted permease Ytrc/YtrD | ABC_transptr_acetoin_YtrC/YtrD | Family | 351 | false | false | The genome of Bacillus subtilis, a well-characterised Gram-positive bacterium, encodes 4,100 protein-coding genes [ ].Within the genome, six ytr genes form a single operon, ytrABCDEF, which may play a role in acetoin utilisation during stationary phase and sporulation, and is believed to encode a putative ATP-binding c... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02026"
] | [
"YTRCYTRDABC"
] | [
351
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054121",
"PUB00054122"
] | [
"9384377",
"10986249"
] | [
"The complete genome sequence of the gram-positive bacterium Bacillus subtilis.",
"An operon for a putative ATP-binding cassette transport system involved in acetoin utilization of Bacillus subtilis."
] | [
1997,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
351
] | 1 | [] | [] | 0 | true | Family | ABC transporter, acetoin utilisation, predicted permease Ytrc/YtrD | ABC transporter, acetoin utilisation, predicted permease Ytrc/YtrD | ABC_transptr_acetoin_YtrC/YtrD | 3 |
IPR023266 | 23,266 | Aquaporin 11 | Aquaporin_11 | Family | 881 | false | false | The aquaporins (AQPs) are a family of integral membrane proteins composed of two subfamilies: the orthodox aquaporins, which transport only water, and the aquaglyceroporins, which transport glycerol, urea, or other small solutes [ ]. AQP1 in pleural mesothelial cells participate in the formation of pleural fluid [ ], r... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02024"
] | [
"AQUAPORIN11"
] | [
881
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-432047",
"R-MMU-432047",
"R-RNO-432047"
] | [
"REACTOME:R-HSA-432047",
"REACTOME:R-MMU-432047",
"REACTOME:R-RNO-432047"
] | 3 | [] | 0 | [
"PUB00043535",
"PUB00043536",
"PUB00043537",
"PUB00043538",
"PUB00043539",
"PUB00054123",
"PUB00054124"
] | [
"16650285",
"18067818",
"18419953",
"17526024",
"17178102",
"19096782",
"18606867"
] | [
"Aquaporin-11: a channel protein lacking apparent transport function expressed in brain.",
"[Effect of hypertonic medium on expression of aquaporin-1 in pleural mesothelial cells: experiment with rats]",
"[Expression of renal aquaporin 2 after circulatory arrest]",
"Aquaporin 9 changes in pyramidal cells befo... | [
2006,
2007,
2008,
2007,
2007,
2009,
2008
] | 7 | [
"IPR016697"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
881
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
3,
5
] | 4 | true | Family | Aquaporin 11 | Aquaporin 11 | Aquaporin_11 | 4 |
IPR023267 | 23,267 | RNA (C5-cytosine) methyltransferase | RCMT | Family | 62,822 | false | false | RNA (C5-cytosine) methyltransferases (RCMTs) catalyse the transfer of a methyl group to the 5th carbon of a cytosine base in RNA sequences to produce C5-methylcytosine. RCMTs use the cofactor S-adenosyl-L-methionine (SAM) as a methyl donor [ ]. The catalytic mechanism of RCMTs involves an attack by the thiolate of a Cy... | [
"GO:0008173",
"GO:0001510"
] | [
"RNA methyltransferase activity",
"RNA methylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS",
"PANTHER",
"PANTHER"
] | [
"PR02008",
"PTHR22807",
"PTHR22808"
] | [
"RCMTFAMILY",
"",
""
] | [
60365,
52540,
9883
] | 3 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1",
"R-HSA-6782315",
"R-HSA-6790901",
"R-HSA-6793080",
"R-HSA-8869496"
] | [
"EC:2.1.1",
"REACTOME:R-HSA-6782315",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6793080",
"REACTOME:R-HSA-8869496"
] | 5 | [
"1ixk",
"1sqf",
"1sqg",
"2b9e",
"2frx",
"2yxl",
"3a4t",
"3ajd",
"3m4x",
"3m6u",
"3m6v",
"3m6w",
"3m6x",
"4fp9",
"4fzv",
"5wwq",
"5wwr",
"5wws",
"5wwt",
"5zvd",
"5zve",
"5zvg",
"5zvh",
"6elz",
"6em5",
"7nac",
"7o9k",
"7o9m",
"7odr",
"7ods",
"7odt",
"7of0"... | 67 | [
"PUB00014203",
"PUB00014205",
"PUB00054125",
"PUB00054126",
"PUB00054127",
"PUB00054128",
"PUB00054129",
"PUB00054130"
] | [
"10026269",
"10454610",
"12826405",
"12220187",
"19135144",
"20007150",
"10194318",
"15121902"
] | [
"Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli.",
"Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences.",
"Many paths to methyltransfer: a chronicle of convergence.",
"RNA methyltransferases utilize t... | [
1999,
1999,
2003,
2002,
2009,
2010,
1999,
2004
] | 8 | [] | [
"IPR004573",
"IPR023268",
"IPR023269",
"IPR023270",
"IPR023273",
"IPR023545",
"IPR043699",
"IPR048151"
] | 0 | 8 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1171,
35315,
25728,
608
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
52,
7,
28,
7,
2,
16,
12,
3,
25,
18,
3,
4,
76
] | 13 | true | Family | RNA (C5-cytosine) methyltransferase | RNA (C5-cytosine) methyltransferase | RCMT | 1 |
IPR023268 | 23,268 | RNA (C5-cytosine) methyltransferase, putative Rsm-related, plant | RCMT_RsmB-rel_pln | Family | 620 | false | false | RNA (C5-cytosine) methyltransferases (RCMTs) catalyse the transfer of a methyl group to the 5th carbon of a cytosine base in RNA sequences to produce C5-methylcytosine. RCMTs use the cofactor S-adenosyl-L-methionine (SAM) as a methyl donor [ ]. The catalytic mechanism of RCMTs involves an attack by the thiolate of a Cy... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02009"
] | [
"RCMTFMUVIRPL"
] | [
620
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00014203",
"PUB00014205",
"PUB00054125",
"PUB00054126",
"PUB00054127",
"PUB00054128",
"PUB00054129",
"PUB00054130"
] | [
"10026269",
"10454610",
"12826405",
"12220187",
"19135144",
"20007150",
"10194318",
"15121902"
] | [
"Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli.",
"Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences.",
"Many paths to methyltransfer: a chronicle of convergence.",
"RNA methyltransferases utilize t... | [
1999,
1999,
2003,
2002,
2009,
2010,
1999,
2004
] | 8 | [
"IPR023267"
] | [] | 1 | 0 | 1 | [
"Streptophyta"
] | [
620
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
2,
8
] | 3 | true | Family | RNA (C5-cytosine) methyltransferase, putative Rsm-related, plant | RNA (C5-cytosine) methyltransferase, putative Rsm-related, plant | RCMT_RsmB-rel_pln | 9 |
IPR023269 | 23,269 | RNA (C5-cytosine) methyltransferase, subfamily 9 | RCMT_subfamily_9 | Family | 839 | false | false | RNA (C5-cytosine) methyltransferases (RCMTs) catalyse the transfer of a methyl group to the 5th carbon of a cytosine base in RNA sequences to produce C5-methylcytosine. RCMTs use the cofactor S-adenosyl-L-methionine (SAM) as a methyl donor [ ]. The catalytic mechanism of RCMTs involves an attack by the thiolate of a Cy... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02010"
] | [
"RCMT9"
] | [
839
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00014203",
"PUB00014205",
"PUB00054125",
"PUB00054126",
"PUB00054127",
"PUB00054128",
"PUB00054129",
"PUB00054130"
] | [
"10026269",
"10454610",
"12826405",
"12220187",
"19135144",
"20007150",
"10194318",
"15121902"
] | [
"Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli.",
"Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences.",
"Many paths to methyltransfer: a chronicle of convergence.",
"RNA methyltransferases utilize t... | [
1999,
1999,
2003,
2002,
2009,
2010,
1999,
2004
] | 8 | [
"IPR023267"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
839
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
3,
8
] | 3 | true | Family | RNA (C5-cytosine) methyltransferase, subfamily 9 | RNA (C5-cytosine) methyltransferase, subfamily 9 | RCMT_subfamily_9 | 2 |
IPR023271 | 23,271 | Aquaporin-like | Aquaporin-like | Homologous_superfamily | 106,871 | false | false | This superfamily represents the aquaporin-like structural domain. The major intrinsic protein (MIP) family is large and diverse, possessing over 100 members that form transmembrane channels. These channel proteins function in water, small carbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport, by an e... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:1.20.1080.10",
"SSF81338"
] | [
"",
""
] | [
106401,
86321
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1237044",
"R-BTA-1247673",
"R-BTA-432040",
"R-BTA-432047",
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"R-CFA-1237044",
"R-CFA-1247673",
"R-CFA-432040",
"R-CFA-432047",
"R-DDI-1237044",
"R-DDI-1247673",
"R-DDI-432040",
"R-DDI-432047",
"R-DME-1237044",
"R-DME-1247673",
"R-DME-432040",
"R-DME-432047",
"R... | [
"REACTOME:R-BTA-1237044",
"REACTOME:R-BTA-1247673",
"REACTOME:R-BTA-432040",
"REACTOME:R-BTA-432047",
"REACTOME:R-CEL-432047",
"REACTOME:R-CFA-1237044",
"REACTOME:R-CFA-1247673",
"REACTOME:R-CFA-432040",
"REACTOME:R-CFA-432047",
"REACTOME:R-DDI-1237044",
"REACTOME:R-DDI-1247673",
"REACTOME:R-D... | 47 | [
"1fqy",
"1fx8",
"1h6i",
"1ih5",
"1j4n",
"1lda",
"1ldf",
"1ldi",
"1rc2",
"1sor",
"1ymg",
"1z98",
"2abm",
"2b5f",
"2b6o",
"2b6p",
"2c32",
"2d57",
"2evu",
"2f2b",
"2o9d",
"2o9e",
"2o9f",
"2o9g",
"2w1p",
"2w2e",
"2zz9",
"3c02",
"3cll",
"3cn5",
"3cn6",
"3d9s"... | 118 | [
"PUB00005368",
"PUB00025063",
"PUB00028718",
"PUB00053662"
] | [
"1715617",
"11039922",
"11780053",
"10957645"
] | [
"Tandem sequence repeats in transmembrane channel proteins.",
"Structure of a glycerol-conducting channel and the basis for its selectivity.",
"Structural basis of water-specific transport through the AQP1 water channel.",
"Crystallization and preliminary X-ray crystallographic analysis of water channel AQP1.... | [
1991,
2000,
2001,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1060,
45884,
59159,
17,
751
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
147,
22,
28,
26,
6,
72,
38,
2,
96,
55,
6,
1,
255
] | 13 | true | Homologous_superfamily | Aquaporin-like | Aquaporin-like | Aquaporin-like | 4 |
IPR023272 | 23,272 | Cytochrome C oxidase, subunit VIIB domain superfamily | Cyt_c_oxidase_suVIIB_dom_sf | Homologous_superfamily | 1,140 | false | false | Cytochrome oxidase subunit VIIB is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport [ ]. The X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution has been determined [ ]. This superfamily rep... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:4.10.51.10",
"SSF81423"
] | [
"",
""
] | [
1139,
1138
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5628897",
"R-HSA-611105",
"R-HSA-9707564",
"R-HSA-9864848",
"R-MMU-5628897",
"R-MMU-611105",
"R-MMU-9707564",
"R-MMU-9864848",
"R-RNO-5628897",
"R-RNO-611105",
"R-RNO-9707564",
"R-RNO-9864848"
] | [
"REACTOME:R-HSA-5628897",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-9707564",
"REACTOME:R-HSA-9864848",
"REACTOME:R-MMU-5628897",
"REACTOME:R-MMU-611105",
"REACTOME:R-MMU-9707564",
"REACTOME:R-MMU-9864848",
"REACTOME:R-RNO-5628897",
"REACTOME:R-RNO-611105",
"REACTOME:R-RNO-9707564",
"REACTOME:R... | 12 | [
"1occ",
"1oco",
"1ocr",
"1ocz",
"1v54",
"1v55",
"2dyr",
"2dys",
"2eij",
"2eik",
"2eil",
"2eim",
"2ein",
"2occ",
"2y69",
"2ybb",
"2zxw",
"3abk",
"3abl",
"3abm",
"3ag1",
"3ag2",
"3ag3",
"3ag4",
"3asn",
"3aso",
"3wg7",
"3x2q",
"5b1a",
"5b1b",
"5b3s",
"5gpn"... | 109 | [
"PUB00011542",
"PUB00097156"
] | [
"10771420",
"28870773"
] | [
"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution.",
"Mitochondrial cytochrome c oxidase biogenesis: Recent developments."
] | [
2000,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1140
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
3,
5
] | 4 | true | Homologous_superfamily | Cytochrome C oxidase, subunit VIIB domain superfamily | Cytochrome C oxidase, subunit VIIB domain superfamily | Cyt_c_oxidase_suVIIB_dom_sf | 5 |
IPR023273 | 23,273 | RNA (C5-cytosine) methyltransferase, NOP2 | RCMT_NOP2 | Family | 4,533 | false | false | The prototypical member of the Nucleolar Protein 2 RCMT subfamily, the S.cerevisiae NOP2, is an essential nucleolar protein required for pre-rRNA processing and 60S ribosomal subunit assembly [ ] that acts as a ribosomal RNA methyltransferase [ , ]. Its human homologue, the proliferation-associated nucleolar antigen P1... | [
"GO:0008168"
] | [
"methyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR02012"
] | [
"RCMTNOP2"
] | [
4533
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 148 | [
"6elz",
"6em5",
"7nac",
"7ohr",
"7r6k",
"7r7a",
"7r7c",
"8esq",
"8esr",
"8fkt",
"8fku",
"8fkv",
"8fkw",
"8fkx",
"8fky",
"8i9r",
"8i9t",
"8i9v",
"8i9w",
"8i9x",
"8i9y",
"8i9z",
"8ia0",
"8v83",
"8v84",
"8v87"
] | 26 | [
"PUB00014203",
"PUB00014205",
"PUB00054125",
"PUB00054126",
"PUB00054127",
"PUB00054128",
"PUB00054129",
"PUB00054130",
"PUB00054131",
"PUB00054137",
"PUB00054138",
"PUB00054139",
"PUB00054140",
"PUB00072550",
"PUB00097261"
] | [
"10026269",
"10454610",
"12826405",
"12220187",
"19135144",
"20007150",
"10194318",
"15121902",
"10445884",
"9854021",
"1394192",
"9531475",
"8041608",
"23913415",
"24120868"
] | [
"Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli.",
"Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences.",
"Many paths to methyltransfer: a chronicle of convergence.",
"RNA methyltransferases utilize t... | [
1999,
1999,
2003,
2002,
2009,
2010,
1999,
2004,
1999,
1999,
1992,
1998,
1994,
2013,
2013
] | 15 | [
"IPR023267"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
4533
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
15,
1,
2,
1,
2,
2,
1,
7,
2,
1,
1,
13
] | 12 | true | Family | RNA (C5-cytosine) methyltransferase, NOP2 | RNA (C5-cytosine) methyltransferase, NOP2 | RCMT_NOP2 | 5 |
IPR023274 | 23,274 | Aquaporin 1 | Aquaporin_1 | Family | 755 | false | false | Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol [ ]. In higher eukaryotes these proteins play diverse roles... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02013"
] | [
"AQUAPORIN1"
] | [
755
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1237044",
"R-BTA-1247673",
"R-BTA-432040",
"R-BTA-432047",
"R-CFA-1237044",
"R-CFA-1247673",
"R-CFA-432040",
"R-CFA-432047",
"R-HSA-1237044",
"R-HSA-1247673",
"R-HSA-432040",
"R-HSA-432047",
"R-HSA-9925563",
"R-MMU-1237044",
"R-MMU-1247673",
"R-MMU-432040",
"R-MMU-432047",
"... | [
"REACTOME:R-BTA-1237044",
"REACTOME:R-BTA-1247673",
"REACTOME:R-BTA-432040",
"REACTOME:R-BTA-432047",
"REACTOME:R-CFA-1237044",
"REACTOME:R-CFA-1247673",
"REACTOME:R-CFA-432040",
"REACTOME:R-CFA-432047",
"REACTOME:R-HSA-1237044",
"REACTOME:R-HSA-1247673",
"REACTOME:R-HSA-432040",
"REACTOME:R-H... | 21 | [
"1fqy",
"1h6i",
"1ih5",
"1j4n",
"4csk",
"6poj",
"7uze",
"8ct2",
"8cte"
] | 9 | [
"PUB00028718",
"PUB00031522",
"PUB00033222",
"PUB00033223",
"PUB00033224",
"PUB00043535",
"PUB00053662",
"PUB00054141",
"PUB00054142",
"PUB00083165"
] | [
"11780053",
"15377788",
"15340377",
"16406529",
"14691544",
"16650285",
"10957645",
"19776169",
"19731985",
"10872456"
] | [
"Structural basis of water-specific transport through the AQP1 water channel.",
"The channel architecture of aquaporin 0 at a 2.2-A resolution.",
"From structure to disease: the evolving tale of aquaporin biology.",
"Why do microorganisms have aquaporins?",
"Architecture and selectivity in aquaporins: 2.5 a... | [
2001,
2004,
2004,
2006,
2003,
2006,
2000,
2009,
2010,
1999
] | 10 | [
"IPR034294"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
755
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
2,
3
] | 3 | true | Family | Aquaporin 1 | Aquaporin 1 | Aquaporin_1 | 7 |
IPR023277 | 23,277 | Aquaporin 8 | Aquaporin_8 | Family | 1,243 | false | false | Aquaporins are water channels, present in both higher and lower organisms, that belong to the major intrinsic protein family. Most aquaporins are highly selective for water, though some also facilitate the movement of small uncharged molecules such as glycerol [ ]. In higher eukaryotes these proteins play diverse roles... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR02020"
] | [
"AQUAPORIN8"
] | [
1243
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3299685",
"R-HSA-432047",
"R-HSA-9925561",
"R-MMU-432047",
"R-RNO-432047"
] | [
"REACTOME:R-HSA-3299685",
"REACTOME:R-HSA-432047",
"REACTOME:R-HSA-9925561",
"REACTOME:R-MMU-432047",
"REACTOME:R-RNO-432047"
] | 5 | [] | 0 | [
"PUB00028718",
"PUB00031522",
"PUB00033222",
"PUB00033223",
"PUB00033224",
"PUB00043535",
"PUB00054147",
"PUB00054148",
"PUB00054149",
"PUB00054150",
"PUB00083165"
] | [
"11780053",
"15377788",
"15340377",
"16406529",
"14691544",
"16650285",
"10449905",
"9806845",
"9374520",
"18948439",
"10872456"
] | [
"Structural basis of water-specific transport through the AQP1 water channel.",
"The channel architecture of aquaporin 0 at a 2.2-A resolution.",
"From structure to disease: the evolving tale of aquaporin biology.",
"Why do microorganisms have aquaporins?",
"Architecture and selectivity in aquaporins: 2.5 a... | [
2001,
2004,
2004,
2006,
2003,
2006,
1999,
1998,
1997,
2009,
1999
] | 11 | [
"IPR034294"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1243
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
2,
4
] | 4 | true | Family | Aquaporin 8 | Aquaporin 8 | Aquaporin_8 | 3 |
IPR023278 | 23,278 | Ethylene insensitive 3-like protein, DNA-binding domain superfamily | Ethylene_insens-like_DNA-bd | Homologous_superfamily | 3,350 | false | false | Ethylene-insensitive3 (EIN3) and EIN3-like (EIL) proteins are essential transcription factors in the ethylene signaling of higher plants. The EIN3/EIL proteins bind to the promoter regions of the downstream genes and regulate their expression. This superfamily represents the DNA-binding domain of EIN3 family proteins, ... | [
"GO:0003700",
"GO:0005634"
] | [
"DNA-binding transcription factor activity",
"nucleus"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:1.10.3180.10",
"SSF116768"
] | [
"",
""
] | [
3278,
3099
] | 2 | [] | [] | [] | 0 | [
"1wij",
"4zds"
] | 2 | [
"PUB00038089"
] | [
"15811366"
] | [
"Solution structure of the major DNA-binding domain of Arabidopsis thaliana ethylene-insensitive3-like3."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Micromonospora fulviviridis"
] | [
3349,
1
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
23,
23,
29
] | 3 | true | Homologous_superfamily | Ethylene insensitive 3-like protein, DNA-binding domain superfamily | Ethylene insensitive 3-like protein, DNA-binding domain superfamily | Ethylene_insens-like_DNA-bd | 8 |
IPR023282 | 23,282 | Hydroxymethylglutaryl-CoA reductase, N-terminal | HMG_CoA_Rdtase_N | Homologous_superfamily | 7,306 | false | false | There are two distinct classes of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase enzymes: class I consists of eukaryotic and most archaeal enzymes ( ), while class II consists of prokaryotic enzymes ( ) [ , ]. Class I HMG-CoA reductases catalyse the NADP-dependent synthesis of mevalonate from 3-hydroxy-3-methylgl... | [
"GO:0004420"
] | [
"hydroxymethylglutaryl-CoA reductase (NADPH) activity"
] | [
"molecular_function"
] | 1 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.3270.10"
] | [
""
] | [
7306
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.1.34",
"PWY-6174",
"PWY-7391",
"PWY-7524",
"PWY-8125",
"PWY-922",
"R-BTA-191273",
"R-DDI-191273",
"R-DME-191273",
"R-HSA-191273",
"R-HSA-1989781",
"R-HSA-2426168",
"R-HSA-9619665",
"R-MMU-191273",
"R-RNO-191273",
"R-SCE-191273",
"R-SPO-191273"
] | [
"EC:1.1.1.34",
"METACYC:PWY-6174",
"METACYC:PWY-7391",
"METACYC:PWY-7524",
"METACYC:PWY-8125",
"METACYC:PWY-922",
"REACTOME:R-BTA-191273",
"REACTOME:R-DDI-191273",
"REACTOME:R-DME-191273",
"REACTOME:R-HSA-191273",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-2426168",
"REACTOME:R-HSA-9619665",
... | 17 | [
"1dq8",
"1dq9",
"1dqa",
"1hw8",
"1hw9",
"1hwi",
"1hwj",
"1hwk",
"1hwl",
"2q1l",
"2q6b",
"2q6c",
"2r4f",
"3bgl",
"3cct",
"3ccw",
"3ccz",
"3cd0",
"3cd5",
"3cd7",
"3cda",
"3cdb",
"3hnp",
"7uli",
"8ecg",
"8pkn",
"8s6b"
] | 27 | [
"PUB00019711",
"PUB00036052",
"PUB00036053",
"PUB00036054"
] | [
"15535874",
"10068515",
"10600463",
"15028676"
] | [
"The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.",
"Sequence comparisons reveal two classes of 3-hydroxy-3-methylglutaryl coenzyme A reductase.",
"Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus.",
"Class II 3-hydroxy-3-methylglutar... | [
2004,
1999,
1999,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Marseillevirus LCMAC201",
"metagenomes"
] | [
172,
161,
6965,
1,
7
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
7,
3,
4,
4,
1,
10,
7,
2,
1,
27
] | 12 | true | Homologous_superfamily | Hydroxymethylglutaryl-CoA reductase, N-terminal | Hydroxymethylglutaryl-CoA reductase, N-terminal | HMG_CoA_Rdtase_N | 4 |
IPR023286 | 23,286 | ABATE domain superfamily | ABATE_dom_sf | Homologous_superfamily | 20,105 | false | false | This superfamily represents the ABATE domain found in DUF1470 [ ]. | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:1.10.3300.10",
"SSF160904"
] | [
"",
""
] | [
19888,
20102
] | 2 | [] | [] | [] | 0 | [
"3h0n"
] | 1 | [
"PUB00054176"
] | [
"20944211"
] | [
"The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 A resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
20046,
8,
5,
46
] | 4 | [] | [] | 0 | true | Homologous_superfamily | ABATE domain superfamily | ABATE domain superfamily | ABATE_dom_sf | 7 |
IPR023291 | 23,291 | Af2093, N-terminal | Af2093-N | Homologous_superfamily | 14 | false | false | This superfamily represents a domain found at the N-terminal of the uncharacterised protein AF2093 , which has no known function. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.3400.10"
] | [
""
] | [
14
] | 1 | [] | [] | [] | 0 | [
"2ph7"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaeoglobaceae"
] | [
14
] | 1 | [] | [] | 0 | true | Homologous_superfamily | Af2093, N-terminal | Af2093, N-terminal | Af2093-N | 7 |
IPR023292 | 23,292 | NTP pyrophosphohydrolase-like domain superfamily | NTP_PyroPHydrolase-like_dom_sf | Homologous_superfamily | 4,864 | false | false | This superfamily represents a putative pyrophosphohydrolase-like domain. It is a variant of the all-α-helical NTP pyrophosphatase fold family and contains an unusual intertwined swapping of helical segments, resulting in an obligatory dimer that cannot dissociate without unfolding of the monomers. This novel "linked di... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.3420.10"
] | [
""
] | [
4864
] | 1 | [] | [] | [] | 0 | [
"2yeu",
"2yf3",
"2yf4",
"2yf9",
"2yfc",
"2yfd",
"3nl9",
"5hva",
"5hwu",
"5hx1",
"5hyl",
"5hzz",
"5i0j",
"5i0m"
] | 14 | [
"PUB00054177"
] | [
"20944217"
] | [
"Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences",
"uncultured archaeon MedDCM-OCT-S02-C115"
] | [
3997,
47,
744,
75,
1
] | 5 | [] | [] | 0 | true | Homologous_superfamily | NTP pyrophosphohydrolase-like domain superfamily | NTP pyrophosphohydrolase-like domain superfamily | NTP_PyroPHydrolase-like_dom_sf | 7 |
IPR023293 | 23,293 | Deoxyguanosinetriphosphate triphosphohydrolase, central domain superfamily | dGTP_triP_hydro_central_sf | Homologous_superfamily | 6,740 | false | false | This domain superfamily is found in the central region of prokaryotic deoxyguanosinetriphosphate triphosphohydrolase proteins. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.3410.10"
] | [
""
] | [
6740
] | 1 | [
"EC"
] | [
"3.1.5.1"
] | [
"EC:3.1.5.1"
] | 1 | [
"2pgs",
"3bg2",
"4x9e",
"4xds",
"6oi7",
"6oiv",
"6oiw",
"6oix",
"6oiy",
"7tu0",
"7tu1",
"7tu2",
"7tu3",
"7tu4",
"7tu5",
"7tu6",
"7tu7",
"7tu8",
"7u65",
"7u66",
"7u67",
"7w1f",
"9p8s",
"9p8t",
"9p8u",
"9p8v"
] | 26 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanolapillus millepedarum",
"metagenomes"
] | [
6685,
12,
1,
42
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Homologous_superfamily | Deoxyguanosinetriphosphate triphosphohydrolase, central domain superfamily | Deoxyguanosinetriphosphate triphosphohydrolase, central domain superfamily | dGTP_triP_hydro_central_sf | 9 |
IPR023294 | 23,294 | Tachylectin 2 | Tachylectin2 | Domain | 819 | false | false | This entry represents a five-bladed β propeller domain from Tachylectin 2. It consists of five four-stranded antiparallel β-sheets are arranged around a water channel. Tachylectin 2 binds specifically to N-acetylglucosamine and N-acetylgalactosamine and is part of the organism's immunity host defense systems [ ]. Tachy... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF14517"
] | [
"Tachylectin"
] | [
819
] | 1 | [] | [] | [] | 0 | [
"1tl2",
"3kif",
"3kih",
"5c2m",
"5c2n",
"8r3b",
"8r3c",
"8r3d",
"9fro"
] | 9 | [
"PUB00031488"
] | [
"10228146"
] | [
"Tachylectin-2: crystal structure of a specific GlcNAc/GalNAc-binding lectin involved in the innate immunity host defense of the Japanese horseshoe crab Tachypleus tridentatus."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Enterobacteria phage L1",
"Eumetazoa"
] | [
508,
1,
310
] | 3 | [] | [] | 0 | true | Domain | Tachylectin 2 | Tachylectin 2 | Tachylectin2 | 8 |
IPR023295 | 23,295 | Hyaluronate lyase, beta-sheet domain superfamily | Hyaluronate_lyase_beta_dom_sf | Homologous_superfamily | 195 | false | false | This entry represents the N-terminal β-sheet domain which adopts a Ig-like fold and may serve as a connection of the α-domain with another structural domain [ ]. Hyaluronate lyase degrades hyaluronan and certain chondroitin sulfates at beta-1,4 glycosidic linkages and constitutes a virulence factor of Streptococcus aga... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:2.60.40.1380"
] | [
""
] | [
195
] | 1 | [] | [] | [] | 0 | [
"1f1s",
"1i8q",
"1lxm"
] | 3 | [
"PUB00024748",
"PUB00027152"
] | [
"11527972",
"12130645"
] | [
"Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase.",
"Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan."
] | [
2001,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
195
] | 1 | [] | [] | 0 | true | Homologous_superfamily | Hyaluronate lyase, beta-sheet domain superfamily | Hyaluronate lyase, beta-sheet domain superfamily | Hyaluronate_lyase_beta_dom_sf | 5 |
IPR023296 | 23,296 | Glycosyl hydrolase, five-bladed beta-propeller domain superfamily | Glyco_hydro_beta-prop_sf | Homologous_superfamily | 133,460 | false | false | This is a five-bladed β-propeller fold catalytic domain where each blade has four twisted antiparallel β-strands radially orientated around a pseudo-5-fold axis [ ]. It can be found in the glycosyl hydrolase family 43 (GH43) members, including beta-xylosidases, alpha-L-arabinanases and bifunctional beta-xylosidases/alp... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:2.115.10.20",
"SSF75005"
] | [
"",
""
] | [
131725,
132091
] | 2 | [
"EC"
] | [
"3.2.1"
] | [
"EC:3.2.1"
] | 1 | [
"1gyd",
"1gye",
"1gyh",
"1oyg",
"1pt2",
"1st8",
"1uv4",
"1uyp",
"1vkd",
"1w18",
"1w2t",
"1wl7",
"1y4w",
"1y7b",
"1y9g",
"1y9m",
"1yi7",
"1yif",
"1yrz",
"2ac1",
"2add",
"2ade",
"2aey",
"2aez",
"2b4w",
"2exh",
"2exi",
"2exj",
"2exk",
"2oxb",
"2qqu",
"2qqv"... | 319 | [
"PUB00017131",
"PUB00022473",
"PUB00050919",
"PUB00051131",
"PUB00088216"
] | [
"14973124",
"14517548",
"18980579",
"19505290",
"28669588"
] | [
"The three-dimensional structure of invertase (beta-fructosidase) from Thermotoga maritima reveals a bimodular arrangement and an evolutionary relationship between retaining and inverting glycosidases.",
"Structural framework of fructosyl transfer in Bacillus subtilis levansucrase.",
"Structural analysis of a g... | [
2004,
2003,
2009,
2009,
2017
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
751,
95157,
36248,
56,
1248
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
76,
1,
9,
69,
1,
2,
97
] | 7 | true | Homologous_superfamily | Glycosyl hydrolase, five-bladed beta-propeller domain superfamily | Glycosyl hydrolase, five-bladed beta-propeller domain superfamily | Glyco_hydro_beta-prop_sf | 3 |
IPR023298 | 23,298 | P-type ATPase, transmembrane domain superfamily | ATPase_P-typ_TM_dom_sf | Homologous_superfamily | 313,839 | false | false | This superfamily represents the ten transmembrane helices domain found in P-type ATPases [ ]. P-ATPases (also known as E1-E2 ATPases) ( ) are found in bacteria and in a number of eukaryotic plasma membranes and organelles [ ]. P-ATPases function to transport a variety of different compounds, including ions and phosphol... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF81665"
] | [
""
] | [
313839
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"7.2.2",
"R-BTA-418359",
"R-BTA-5578775",
"R-BTA-936837",
"R-CEL-418359",
"R-CEL-5578775",
"R-CEL-6798695",
"R-CEL-936837",
"R-CFA-418359",
"R-CFA-5578775",
"R-CFA-936837",
"R-DDI-418359",
"R-DDI-5578775",
"R-DDI-936837",
"R-DME-418359",
"R-DME-5578775",
"R-DME-936837",
"R-DRE-9368... | [
"EC:7.2.2",
"REACTOME:R-BTA-418359",
"REACTOME:R-BTA-5578775",
"REACTOME:R-BTA-936837",
"REACTOME:R-CEL-418359",
"REACTOME:R-CEL-5578775",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-936837",
"REACTOME:R-CFA-418359",
"REACTOME:R-CFA-5578775",
"REACTOME:R-CFA-936837",
"REACTOME:R-DDI-418359",
"... | 54 | [
"1iwo",
"1kju",
"1mhs",
"1su4",
"1t5s",
"1t5t",
"1vfp",
"1wpg",
"1xp5",
"2agv",
"2by4",
"2c88",
"2c8k",
"2c8l",
"2c9m",
"2dqs",
"2ear",
"2eat",
"2eau",
"2o9j",
"2oa0",
"2voy",
"2xzb",
"2yfy",
"2yn9",
"2zbd",
"2zbe",
"2zbf",
"2zbg",
"2zxe",
"3a3y",
"3ar2"... | 410 | [
"PUB00009616",
"PUB00020603",
"PUB00020604",
"PUB00050541",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789",
"PUB00160065",
"PUB00160066"
] | [
"9419228",
"15473999",
"15078220",
"18075595",
"20450191",
"18937357",
"1385979",
"9741106",
"37264943",
"37838176"
] | [
"Evolution of substrate specificities in the P-type ATPase superfamily.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.",
"Mechanisms of ATPases--a multi-disciplinary approach.",
"Crystal structure of the plasma membrane proton ... | [
1998,
2004,
2004,
2007,
2010,
2008,
1992,
1998,
2023,
2023
] | 10 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3829,
131973,
176214,
79,
1744
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
244,
49,
204,
94,
5,
216,
186,
18,
178,
242,
16,
14,
622
] | 13 | true | Homologous_superfamily | P-type ATPase, transmembrane domain superfamily | P-type ATPase, transmembrane domain superfamily | ATPase_P-typ_TM_dom_sf | 3 |
IPR023299 | 23,299 | P-type ATPase, cytoplasmic domain N | ATPase_P-typ_cyto_dom_N | Homologous_superfamily | 299,487 | false | false | This superfamily represents the cytoplasmic domain N found in P-type ATPases. The cytoplasmic loops of the P-type ATPases form three separate modules, commonly named the A, P and N-domains [ , ]. The N-domain comprises the nucleotide binding site [ ]. This domain forms a seven-stranded antiparallel β-sheet with two add... | [
"GO:0000166"
] | [
"nucleotide binding"
] | [
"molecular_function"
] | 1 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:3.40.1110.10",
"SSF81660"
] | [
"",
""
] | [
298795,
169749
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"7.2.2",
"R-BTA-418359",
"R-BTA-5578775",
"R-BTA-936837",
"R-CEL-418359",
"R-CEL-5578775",
"R-CEL-6798695",
"R-CEL-936837",
"R-CFA-418359",
"R-CFA-5578775",
"R-CFA-936837",
"R-DDI-418359",
"R-DDI-5578775",
"R-DDI-936837",
"R-DME-418359",
"R-DME-5578775",
"R-DME-936837",
"R-DRE-9368... | [
"EC:7.2.2",
"REACTOME:R-BTA-418359",
"REACTOME:R-BTA-5578775",
"REACTOME:R-BTA-936837",
"REACTOME:R-CEL-418359",
"REACTOME:R-CEL-5578775",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-936837",
"REACTOME:R-CFA-418359",
"REACTOME:R-CFA-5578775",
"REACTOME:R-CFA-936837",
"REACTOME:R-DDI-418359",
"... | 53 | [
"1iwo",
"1kju",
"1mhs",
"1mo7",
"1mo8",
"1q3i",
"1su4",
"1svj",
"1t5s",
"1t5t",
"1u7q",
"1vfp",
"1wpg",
"1xp5",
"2a00",
"2a29",
"2agv",
"2arf",
"2b8e",
"2by4",
"2c88",
"2c8k",
"2c8l",
"2c9m",
"2dqs",
"2ear",
"2eat",
"2eau",
"2iye",
"2kmv",
"2kmx",
"2koy"... | 427 | [
"PUB00009616",
"PUB00022866",
"PUB00037433",
"PUB00038122",
"PUB00097365",
"PUB00160065",
"PUB00160066"
] | [
"9419228",
"15364580",
"14499619",
"15448704",
"28443028",
"37264943",
"37838176"
] | [
"Evolution of substrate specificities in the P-type ATPase superfamily.",
"Inter-domain motions of the N-domain of the KdpFABC complex, a P-type ATPase, are not driven by ATP-induced conformational changes.",
"The crystallographic structure of Na,K-ATPase N-domain at 2.6A resolution.",
"Lumenal gating mechani... | [
1998,
2004,
2003,
2004,
2017,
2023,
2023
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
4114,
132355,
161340,
19,
1659
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
234,
47,
196,
78,
4,
161,
135,
19,
153,
201,
16,
14,
553
] | 13 | true | Homologous_superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, cytoplasmic domain N | ATPase_P-typ_cyto_dom_N | 7 |
IPR023301 | 23,301 | Ammonia/methane monooxygenase, subunitB, N-terminal | NH3_CH4_mOase_suB_N | Homologous_superfamily | 396 | false | false | This entry represents the N-terminal β-barrel-like domain of subunit B. Ammonia monooxygenase and the particulate methane monooxygenase are both integral membrane proteins, occurring in ammonia oxidisers and methanotrophs respectively, which are thought to be evolutionarily related [ ]. These enzymes have a relatively ... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:2.60.120.570"
] | [
""
] | [
396
] | 1 | [] | [] | [] | 0 | [
"1yew",
"3chx",
"3rfr",
"3rgb",
"4o65",
"4phz",
"4pi0",
"4pi2",
"6cxh",
"7ev9",
"7s4h",
"7s4i",
"7s4j",
"7s4k",
"7s4l",
"7s4m",
"7t4o",
"7t4p",
"7yzy",
"8oyi",
"8sqw",
"8sr1",
"8sr2",
"8sr4",
"8sr5",
"9cl1",
"9cl2",
"9cl3",
"9cl4",
"9cl5",
"9cl6"
] | 31 | [
"PUB00016963",
"PUB00016964",
"PUB00016965"
] | [
"7590173",
"12209257",
"15674245"
] | [
"Evidence that particulate methane monooxygenase and ammonia monooxygenase may be evolutionarily related.",
"Molecular biology and biochemistry of ammonia oxidation by Nitrosomonas europaea.",
"Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane."
] | [
1995,
2002,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
106,
277,
13
] | 3 | [] | [] | 0 | true | Homologous_superfamily | Ammonia/methane monooxygenase, subunitB, N-terminal | Ammonia/methane monooxygenase, subunitB, N-terminal | NH3_CH4_mOase_suB_N | 4 |
IPR023302 | 23,302 | Peptidase S9A, N-terminal domain | Pept_S9A_N | Domain | 32,835 | false | false | This entry represents the β-propeller domain found at the N-terminal of prolyl oligopeptidase from the MEROPS peptidase family S9A. The prolyl oligopeptidase family consist of a number of evolutionary related peptidases whose catalytic activity seems to be provided by a charge relay system similar to that of the trypsi... | [
"GO:0004252"
] | [
"serine-type endopeptidase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF02897"
] | [
"Peptidase_S9_N"
] | [
32835
] | 1 | [
"EC"
] | [
"3.4.21"
] | [
"EC:3.4.21"
] | 1 | [
"1e5t",
"1e8m",
"1e8n",
"1h2w",
"1h2x",
"1h2y",
"1h2z",
"1o6f",
"1o6g",
"1qfm",
"1qfs",
"1uoo",
"1uop",
"1uoq",
"1vz2",
"1vz3",
"1yr2",
"2bkl",
"2xdw",
"2xe4",
"3ddu",
"3eq7",
"3eq8",
"3eq9",
"3iuj",
"3iul",
"3ium",
"3iun",
"3iuq",
"3iur",
"3ivm",
"3mun"... | 83 | [
"PUB00020062"
] | [
"9695945"
] | [
"Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Klosneuvirinae",
"unclassified sequences"
] | [
231,
22931,
9366,
2,
305
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
34,
6,
7,
1,
5,
7,
12,
12,
50
] | 9 | true | Domain | Peptidase S9A, N-terminal domain | Peptidase S9A, N-terminal domain | Pept_S9A_N | 7 |
IPR023303 | 23,303 | Ammonia/methane monooxygenase, subunit B, C-terminal | NH3_CH4_mOase_suB_C | Homologous_superfamily | 243 | false | false | Ammonia monooxygenase and the particulate methane monooxygenase are both integral membrane proteins, occurring in ammonia oxidisers and methanotrophs respectively, which are thought to be evolutionarily related [ ]. These enzymes have a relatively wide substrate specificity and can catalyse the oxidation of a range of ... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:2.60.40.1580"
] | [
""
] | [
243
] | 1 | [] | [] | [] | 0 | [
"1yew",
"3chx",
"3rfr",
"3rgb",
"4phz",
"4pi0",
"4pi2",
"6cxh",
"7ev9",
"7s4h",
"7s4i",
"7s4j",
"7s4k",
"7s4l",
"7s4m",
"7t4o",
"7t4p",
"7yzy",
"8oyi",
"8sqw",
"8sr1",
"8sr2",
"8sr4",
"8sr5",
"9cl1",
"9cl2",
"9cl3",
"9cl4",
"9cl5",
"9cl6"
] | 30 | [
"PUB00016963",
"PUB00016964",
"PUB00016965"
] | [
"7590173",
"12209257",
"15674245"
] | [
"Evidence that particulate methane monooxygenase and ammonia monooxygenase may be evolutionarily related.",
"Molecular biology and biochemistry of ammonia oxidation by Nitrosomonas europaea.",
"Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane."
] | [
1995,
2002,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
239,
4
] | 2 | [] | [] | 0 | true | Homologous_superfamily | Ammonia/methane monooxygenase, subunit B, C-terminal | Ammonia/methane monooxygenase, subunit B, C-terminal | NH3_CH4_mOase_suB_C | 9 |
IPR023309 | 23,309 | Endoglucanase F, domain 2 | Endo-1-4-beta-glucanase_dom2 | Homologous_superfamily | 1,566 | false | false | This structural domain is found in endoglucanase F. Proteins containing this domain include endoglucanases and exoglucanases. They are involved in the cellulose catabolic process. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:2.170.160.10"
] | [
""
] | [
1566
] | 1 | [] | [] | [] | 0 | [
"1f9d",
"1f9o",
"1fae",
"1fbo",
"1fbw",
"1fce",
"1g9g",
"1g9j",
"1l1y",
"1l2a",
"2qno",
"4el8",
"4fus",
"4jjj",
"4l0g",
"4l6x",
"4txt",
"4xwl",
"4xwm",
"4xwn",
"5yj6",
"6d5d",
"8zu1"
] | 23 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Opisthokonta",
"uncultured organism"
] | [
1417,
5,
118,
26
] | 4 | [] | [] | 0 | true | Homologous_superfamily | Endoglucanase F, domain 2 | Endoglucanase F, domain 2 | Endo-1-4-beta-glucanase_dom2 | 4 |
IPR023311 | 23,311 | Methuselah ectodomain, domain 2 | Methusela_ecto_dom_2 | Homologous_superfamily | 1,813 | false | false | Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor ... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:2.170.180.11"
] | [
""
] | [
1813
] | 1 | [] | [] | [] | 0 | [
"1fjr",
"2pzx"
] | 2 | [
"PUB00012777",
"PUB00048826"
] | [
"11274391",
"17546039"
] | [
"Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan.",
"Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor."
] | [
2001,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Amsacta moorei entomopoxvirus",
"Pancrustacea"
] | [
1,
1812
] | 2 | [
"Drosophila melanogaster"
] | [
23
] | 1 | true | Homologous_superfamily | Methuselah ectodomain, domain 2 | Methuselah ectodomain, domain 2 | Methusela_ecto_dom_2 | 7 |
IPR023312 | 23,312 | Putative nitroreductase, C-terminal, bacterial | Put_nitroreductase_C_bac | Homologous_superfamily | 774 | false | false | This superfamily represents the C-terminal domain found in proteins putatively annotated as bacterial nitroreductases. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:2.20.180.10"
] | [
""
] | [
774
] | 1 | [] | [] | [] | 0 | [
"2r01"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
6,
709,
59
] | 3 | [] | [] | 0 | true | Homologous_superfamily | Putative nitroreductase, C-terminal, bacterial | Putative nitroreductase, C-terminal, bacterial | Put_nitroreductase_C_bac | 3 |
IPR023313 | 23,313 | Ubiquitin-conjugating enzyme, active site | UBQ-conjugating_AS | Active_site | 81,208 | false | false | Ubiquitin-conjugating enzymes ( , UBC or E2 enzymes) catalyse the covalent attachment of ubiquitin to target proteins. Ubiquitin is conjugated to the target protein through the coordinated action of three enzyme activities designated E1, E2, and E3. The E1 or ubiquitin-activating enzyme forms, in an ATP-dependent manne... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00183"
] | [
"UBC_1"
] | [
81208
] | 1 | [
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"2.3.2",
"2.3.2.23",
"PWY-7511",
"R-BTA-110314",
"R-BTA-1169408",
"R-BTA-1234176",
"R-BTA-141430",
"R-BTA-174048",
"R-BTA-174084",
"R-BTA-174154",
"R-BTA-174178",
"R-BTA-174184",
"R-BTA-176407",
"R-BTA-176408",
"R-BTA-176409",
"R-BTA-176412",
"R-BTA-179409",
"R-BTA-201451",
"R-BT... | [
"EC:2.3.2",
"EC:2.3.2.23",
"METACYC:PWY-7511",
"REACTOME:R-BTA-110314",
"REACTOME:R-BTA-1169408",
"REACTOME:R-BTA-1234176",
"REACTOME:R-BTA-141430",
"REACTOME:R-BTA-174048",
"REACTOME:R-BTA-174084",
"REACTOME:R-BTA-174154",
"REACTOME:R-BTA-174178",
"REACTOME:R-BTA-174184",
"REACTOME:R-BTA-17... | 453 | [
"1a3s",
"1ayz",
"1c4z",
"1fbv",
"1fxt",
"1fzy",
"1j7d",
"1jas",
"1jat",
"1jbb",
"1kps",
"1pzv",
"1q34",
"1qcq",
"1tte",
"1u9a",
"1u9b",
"1ur6",
"1w4u",
"1wzv",
"1wzw",
"1x23",
"1y6l",
"1y8x",
"1yf9",
"1yh2",
"1yla",
"1yrv",
"1z2u",
"1z3d",
"1z5s",
"1zdn"... | 328 | [
"PUB00000623",
"PUB00005354",
"PUB00005373",
"PUB00040358"
] | [
"1647207",
"2193438",
"1656558",
"10350465"
] | [
"Genetic analysis of the ubiquitin system.",
"Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells.",
"The ubiquitin pathway for protein degradation.",
"Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 A resolution."
] | [
1991,
1990,
1991,
1999
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Nucleocytoviricota",
"metagenomes"
] | [
3,
11,
81069,
47,
78
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
108,
11,
45,
44,
94,
92,
10,
64,
105,
12,
10,
198
] | 12 | true | Active_site | Ubiquitin-conjugating enzyme, active site | Ubiquitin-conjugating enzyme, active site | UBQ-conjugating_AS | 6 |
IPR023314 | 23,314 | 5-Dehydro-2-deoxygluconokinase-like superfamily | Myo_inos_IolC-like_sf | Homologous_superfamily | 7,627 | false | false | This superfamily represents a β-sheet structural domain found at the N terminus of 5-dehydro-2-deoxygluconokinases [ ], which catalyse the fifth step in degradation from myo-inositol or closely related compounds. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:2.20.150.10"
] | [
""
] | [
7627
] | 1 | [
"EC"
] | [
"2.7.1.92"
] | [
"EC:2.7.1.92"
] | 1 | [
"2qcv",
"3bf5",
"3pl2"
] | 3 | [
"PUB00053908"
] | [
"18310071"
] | [
"myo-Inositol catabolism in Bacillus subtilis."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
17,
7224,
315,
71
] | 4 | [
"Zea mays"
] | [
3
] | 1 | true | Homologous_superfamily | 5-Dehydro-2-deoxygluconokinase-like superfamily | 5-Dehydro-2-deoxygluconokinase-like superfamily | Myo_inos_IolC-like_sf | 3 |
IPR023315 | 23,315 | SynGAP C2 domain, N-terminal | SynGAP_C2_N | Homologous_superfamily | 46 | false | false | This entry represents a small structural domain found at the extreme N terminus of the C2 domain of Ras GTPase-activating protein SynGAP [ ]. | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:2.20.170.10"
] | [
""
] | [
46
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00050812"
] | [
"18323856"
] | [
"The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
46
] | 1 | [] | [] | 0 | true | Homologous_superfamily | SynGAP C2 domain, N-terminal | SynGAP C2 domain, N-terminal | SynGAP_C2_N | 4 |
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