LiteFold/InterPro · Datasets at Hugging Face

IPR023317

23,317

Peptidase S1A, plasmin

Pept_S1A_plasmin

Family

1,136

false

Plasmin is a serine peptidase belonging to MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)), subfamily S1A. Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes, including embryonic development, tissue remodeling, tumor invasion, and inflammation [ ]; ...

[ "GO:0004252" ]

[ "serine-type endopeptidase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF001150" ]

[ "Plasmin" ]

[ 1136 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.21.7", "GenProp2010", "R-HSA-114608", "R-HSA-1474228", "R-HSA-1592389", "R-HSA-186797", "R-HSA-381426", "R-HSA-75205", "R-MMU-114608", "R-MMU-1592389", "R-MMU-186797", "R-MMU-75205", "R-RNO-114608", "R-RNO-1592389", "R-RNO-186797", "R-RNO-381426", "R-RNO-75205" ]

[ "EC:3.4.21.7", "GP:GenProp2010", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-1592389", "REACTOME:R-HSA-186797", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-75205", "REACTOME:R-MMU-114608", "REACTOME:R-MMU-1592389", "REACTOME:R-MMU-186797", "REACTOME:R-MMU-75205", "REACTOM...

17

[ "4a5t", "4dur", "4duu", "8uq6" ]

4

[ "PUB00100482" ]

[ "14699093" ]

[ "Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells." ]

[ 2004 ]

1

[ "IPR001314" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1136 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 2, 5 ]

4

true

Family

Peptidase S1A, plasmin

Pept_S1A_plasmin

6

IPR023318

23,318

Ubiquitin activating enzyme, alpha domain superfamily

Ub_act_enz_dom_a_sf

Homologous_superfamily

9,997

false

Ubiquitin-activating enzyme (E1 enzyme) activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP. Later the ubiquitin moiety is transferred to a cysteine residue on...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.10.520" ]

[ "" ]

[ 9997 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-3065676", "R-CEL-3065678", "R-CEL-8951664", "R-CEL-983168", "R-DDI-3065676", "R-DDI-3065678", "R-DDI-8951664", "R-DDI-983168", "R-DME-8951664", "R-DME-983168", "R-DRE-3065676", "R-DRE-3065678", "R-DRE-8951664", "R-DRE-983168", "R-HSA-3065676", "R-HSA-3065678", "R-HSA-5607761",...

[ "REACTOME:R-CEL-3065676", "REACTOME:R-CEL-3065678", "REACTOME:R-CEL-8951664", "REACTOME:R-CEL-983168", "REACTOME:R-DDI-3065676", "REACTOME:R-DDI-3065678", "REACTOME:R-DDI-8951664", "REACTOME:R-DDI-983168", "REACTOME:R-DME-8951664", "REACTOME:R-DME-983168", "REACTOME:R-DRE-3065676", "REACTOME:R...

40

[ "1r4m", "1r4n", "1tt5", "1y8q", "1y8r", "1yov", "2nvu", "2px9", "3dbh", "3dbl", "3dbr", "3gzn", "3kyc", "3kyd", "6cwy", "6cwz", "6xog", "6xoh", "6xoi", "9dqb", "9drj" ]

21

[ "PUB00044523", "PUB00044524" ]

[ "1986373", "11004499" ]

[ "Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.", "Molecular cloning of cDNA encoding a ubiquitin-activating enzyme (E1) from goldfish (Carassius auratus) and expression analysis of the cloned gene." ]

[ 1991, 2000 ]

2

[]

0

null

[ "Eukaryota" ]

[ 9997 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 8, 4, 13, 5, 4, 5, 12, 2, 2, 27 ]

12

true

Homologous_superfamily

Ubiquitin activating enzyme, alpha domain superfamily

Ub_act_enz_dom_a_sf

2

IPR023319

23,319

Tex-like protein, HTH domain superfamily

Tex-like_HTH_dom_sf

Homologous_superfamily

26,703

false

Tex (toxin expression) is a highly conserved bacterial protein involved in expression of critical toxin genes [ ]. The overall structure is notably flat and elongated. The most striking structural feature is a long, central helix comprising from amino acid residue 274 to 322. The rest of the protein wraps around the ce...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.10.650" ]

[ "" ]

[ 26703 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-112382", "R-CEL-674695", "R-CEL-75955", "R-DME-112382", "R-DME-674695", "R-DME-75955", "R-HSA-112382", "R-HSA-674695", "R-HSA-75955", "R-MMU-112382", "R-MMU-674695", "R-MMU-75955" ]

[ "REACTOME:R-CEL-112382", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-75955", "REACTOME:R-DME-112382", "REACTOME:R-DME-674695", "REACTOME:R-DME-75955", "REACTOME:R-HSA-112382", "REACTOME:R-HSA-674695", "REACTOME:R-HSA-75955", "REACTOME:R-MMU-112382", "REACTOME:R-MMU-674695", "REACTOME:R-MMU-75955"...

12

[ "2oce", "3bzc", "3bzk", "3psf", "3psi", "6gmh", "6ted", "7o3d", "7o6b", "7oop", "7opc", "7opd", "7unc", "7und", "7xn7", "7xse", "7xsx", "7xsz", "7xt7", "7xtd", "7xti", "8a3y", "8oeu", "8oev", "8of0", "8xrm", "9egx", "9egy", "9egz", "9eh0", "9eh1", "9eh2"...

39

[ "PUB00044514", "PUB00050835" ]

[ "8755871", "18321528" ]

[ "A new gene locus of Bordetella pertussis defines a novel family of prokaryotic transcriptional accessory proteins.", "Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa." ]

[ 1996, 2008 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 64, 19414, 7096, 129 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 11, 2, 9, 4, 1, 3, 3, 1, 1, 10, 1, 1, 14 ]

13

true

Homologous_superfamily

Tex-like protein, HTH domain superfamily

Tex-like_HTH_dom_sf

6

IPR023321

23,321

PINIT domain

PINIT

Domain

8,525

false

This entry represents the PINIT domain found in the Siz/PIAS RING family of SUMO E3 ligases [ ]. These proteins present a tripartite architecture with an N-terminal PINIT domain, a central zinc-containing RING-like SP-RING domain, and a C-terminal domain desginated SP-CTD. Structural and biochemical studies have shown ...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF14324", "PS51466" ]

[ "PINIT", "PINIT" ]

[ 8297, 8435 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME"...

[ "2.3.2.-", "PWY-6289", "PWY-6462", "PWY-6463", "PWY-6682", "PWY-6841", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-7887", "R-CEL-3108214", "R-CEL-3232118", "R-CEL-3232142", "R-CEL-3899300", "R-CEL-4085377", "R-CEL-4090294", "R-CEL-4551638", "R-CEL-5696395", "R-CEL-8773...

[ "EC:2.3.2.-", "METACYC:PWY-6289", "METACYC:PWY-6462", "METACYC:PWY-6463", "METACYC:PWY-6682", "METACYC:PWY-6841", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-7887", "REACTOME:R-CEL-3108214", "REACTOME:R-CEL-3232118", "REACTOME:R-CEL-3232142"...

78

[ "3i2d", "4fo9", "4mvt", "5jne", "6u75" ]

5

[ "PUB00054205", "PUB00054206" ]

[ "19748360", "14596924" ]

[ "Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA.", "The 'PINIT' motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L." ]

[ 2009, 2003 ]

2

[]

0

null

[ "Eukaryota" ]

[ 8525 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 23, 16, 19, 15, 2, 32, 2, 1 ]

9

true

Domain

PINIT domain

PINIT

6

IPR023322

23,322

Outer surface lipoprotein domain superfamily

OM_lipoprot_dom_sf

Homologous_superfamily

873

false

The ospA and ospB genes encode the major outer membrane proteins of the Lyme disease spirochaete Borrelia burgdorferi [ ]. The deduced gene products OspA and OspB, contain 273 and 296 residues respectively [ ]. The two Osp proteins show a high degree of sequence similarity, indicating a recent evolutionary event. Molec...

[]

0

[ "SSF" ]

[ "SSF51087" ]

[ "" ]

[ 873 ]

1

[]

0

[ "1fj1", "1osp", "1p4p", "1rjl", "2af5", "2fkg", "2fkj", "2g8c", "2hkd", "2i5v", "2i5z", "2ol6", "2ol7", "2ol8", "2oy1", "2oy5", "2oy7", "2oy8", "2oyb", "2pi3", "3aum", "3cka", "3ckf", "3ckg", "3ec5", "3eex", "5b2a", "5ys7", "5z1o", "6ais", "6ics", "6idc"...

65

[ "PUB00003793", "PUB00003832" ]

[ "2761388", "1560779" ]

[ "Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi.", "Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22 kDa protein (pC) in Escherichia coli." ]

[ 1989, 1992 ]

2

[]

0

null

[ "Bacteria" ]

[ 873 ]

1

[]

0

true

Homologous_superfamily

Outer surface lipoprotein domain superfamily

OM_lipoprot_dom_sf

4

IPR023323

23,323

Tex-like domain superfamily

Tex-like_dom_sf

Homologous_superfamily

27,161

false

This superfamily represents a domain comprising amino acids 115-327 and 456-502, flanking the YqgF domain ( ). Tex (toxin expression) is a highly conserved bacterial protein involved in expression of critical toxin genes [ ]. The overall structure is notably flat and elongated. The most striking structural feature is a...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.3500.10" ]

[ "" ]

[ 27161 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-112382", "R-CEL-674695", "R-CEL-75955", "R-DME-112382", "R-DME-674695", "R-DME-75955", "R-HSA-112382", "R-HSA-674695", "R-HSA-75955", "R-MMU-112382", "R-MMU-674695", "R-MMU-75955" ]

[ "REACTOME:R-CEL-112382", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-75955", "REACTOME:R-DME-112382", "REACTOME:R-DME-674695", "REACTOME:R-DME-75955", "REACTOME:R-HSA-112382", "REACTOME:R-HSA-674695", "REACTOME:R-HSA-75955", "REACTOME:R-MMU-112382", "REACTOME:R-MMU-674695", "REACTOME:R-MMU-75955"...

12

[ "2oce", "3bzc", "3bzk", "3psf", "3psi", "6gmh", "6ted", "7o3d", "7o6b", "7oop", "7opc", "7opd", "7unc", "7und", "7xn7", "7xse", "7xsx", "7xsz", "7xt7", "7xtd", "7xti", "8a3y", "8oeu", "8oev", "8of0", "8xrm", "9egx", "9egy", "9egz", "9eh0", "9eh1", "9eh2"...

39

[ "PUB00044514", "PUB00050835" ]

[ "8755871", "18321528" ]

[ "A new gene locus of Bordetella pertussis defines a novel family of prokaryotic transcriptional accessory proteins.", "Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa." ]

[ 1996, 2008 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 64, 19587, 7355, 155 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 11, 2, 9, 4, 1, 5, 3, 1, 1, 10, 1, 1, 11 ]

13

true

Homologous_superfamily

Tex-like domain superfamily

Tex-like_dom_sf

2

IPR023324

23,324

BH2638-like superfamily

BH2638-like_sf

Homologous_superfamily

2,432

false

This superfamily represents an orthogonal bundle domain found in proteins belonging to the uncharacterised protein family UPF0223, including protein BH2638.

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.10.220.80", "SSF158504" ]

[ "", "" ]

[ 2423, 2432 ]

2

[]

0

[ "2oy9" ]

1

[]

0

[]

0

null

[ "Bacteria", "Fervidicoccus fontis", "Opisthokonta", "metagenomes", "uncultured Caudovirales phage" ]

[ 2423, 2, 2, 4, 1 ]

5

[]

0

true

Homologous_superfamily

BH2638-like superfamily

BH2638-like_sf

8

IPR023330

23,330

Rhabdovirus nucleocapsid, N-terminal

Rhabdovirus_ncapsid_N

Homologous_superfamily

10,515

false

All negative-strand RNA viruses contain a ribonucleoprotein (RNP) complex that consists of the viral genome RNA completely enwrapped by the nucleoprotein (N). The crystal structure of the N protein in complex with a single-strand RNA has been determined for two members of the rhabdovirus family, VSV [ ] and RABV [ ]. T...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.3570.10" ]

[ "" ]

[ 10515 ]

1

[]

0

[ "2gic", "2gtt", "2qvj", "2wyy", "3hhw", "3hhz", "3pmk", "3pto", "3ptx", "3pu0", "3pu1", "3pu4", "5uk4", "5ukb", "6bjy", "7umk", "7uml", "7uws", "7xpn", "7yg7", "8b8v", "8ffr", "8fwl", "8u0a", "8u0b" ]

25

[ "PUB00041063", "PUB00041177", "PUB00049163" ]

[ "16778022", "16778023", "18003727" ]

[ "Structure of the vesicular stomatitis virus nucleoprotein-RNA complex.", "Crystal structure of the rabies virus nucleoprotein-RNA complex.", "Role of intermolecular interactions of vesicular stomatitis virus nucleoprotein in RNA encapsidation." ]

[ 2006, 2006, 2008 ]

3

[]

0

null

[ "Protostomia", "Riboviria" ]

[ 166, 10349 ]

2

[]

0

true

Homologous_superfamily

Rhabdovirus nucleocapsid, N-terminal

Rhabdovirus_ncapsid_N

5

IPR023331

23,331

Rhabdovirus nucleocapsid, C-terminal

Rhabdovirus_ncapsid_C

Homologous_superfamily

9,292

false

All negative-strand RNA viruses contain a ribonucleoprotein (RNP) complex that consists of the viral genome RNA completely enwrapped by the nucleoprotein (N). The crystal structure of the N protein in complex with a single-strand RNA has been determined for two members of the rhabdovirus family, VSV [ ] and RABV [ ]. T...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.3610.10" ]

[ "" ]

[ 9292 ]

1

[]

0

[ "2gic", "2gtt", "2qvj", "2wyy", "3hhw", "3hhz", "3pmk", "3pto", "3ptx", "3pu0", "3pu1", "3pu4", "5uk4", "5ukb", "6bjy", "7umk", "7uml", "7uws", "7xpn", "7yg7", "8b8v", "8ffr", "8fwl", "8u0a", "8u0b" ]

25

[ "PUB00041063", "PUB00041177", "PUB00049163" ]

[ "16778022", "16778023", "18003727" ]

[ "Structure of the vesicular stomatitis virus nucleoprotein-RNA complex.", "Crystal structure of the rabies virus nucleoprotein-RNA complex.", "Role of intermolecular interactions of vesicular stomatitis virus nucleoprotein in RNA encapsidation." ]

[ 2006, 2006, 2008 ]

3

[]

0

null

[ "Protostomia", "Riboviria" ]

[ 181, 9111 ]

2

[]

0

true

Homologous_superfamily

Rhabdovirus nucleocapsid, C-terminal

Rhabdovirus_ncapsid_C

9

IPR023332

23,332

Proteasome alpha-type subunit

Proteasome_alpha-type

Family

39,918

false

ATP-dependent protease complexes are present in all three kingdoms of life, where they rid the cell of misfolded or damaged proteins and control the level of certain regulatory proteins. They include the proteasome in Eukaryotes, Archaea, and Actinomycetales and the HslVU (ClpQY, clpXP) complex in other eubacteria. Gen...

[]

0

[ "PROFILE" ]

[ "PS51475" ]

[ "PROTEASOME_ALPHA_2" ]

[ 39918 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1236974", "R-BTA-1236978", "R-BTA-174084", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA-2467813", "R-BTA-2871837", "R-BTA-349425", "R-BTA-350562", "R-BTA-382556", "R-BTA-450408", "R-B...

[ "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1236974", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-174084", "REACTOME:R-BTA-174154", "REACTOME:R-BTA-174178", "REACTOME:R-BTA-174184", "REACTOME:R-BTA-187577", "REACTOME:R-BTA-195253", "REACTOME:R-BTA-202424", "REACTOME:R-BTA...

365

[ "1fnt", "1g0u", "1g65", "1iru", "1j2p", "1j2q", "1jd2", "1pma", "1q5q", "1q5r", "1ryp", "1ya7", "1yar", "1yau", "1z7q", "2f16", "2fak", "2fhg", "2fhh", "2gpl", "2h6j", "2ku1", "2ku2", "2z5c", "2zcy", "3bdm", "3c91", "3c92", "3d29", "3dy3", "3dy4", "3e47"...

621

[ "PUB00000148", "PUB00000524", "PUB00001329", "PUB00004123", "PUB00005460", "PUB00011906", "PUB00014349", "PUB00014350", "PUB00030848", "PUB00080992" ]

[ "2643381", "7682410", "7697118", "1317508", "8882582", "12446803", "12646382", "12823960", "9087403", "2535672" ]

[ "The multicatalytic proteinase of mammalian cells.", "Proteasomes: multicatalytic proteinase complexes.", "Proteasomes. Multicatalytic proteinase complexes.", "Proteolysis, proteasomes and antigen presentation.", "Proteasomes: destruction as a programme.", "Eubacterial HslV and HslU subunits homologs in p...

[ 1989, 1993, 1993, 1992, 1996, 2002, 2003, 2003, 1997, 1989 ]

10

[ "IPR001353" ]

[ "IPR019982", "IPR022296", "IPR033812", "IPR034642", "IPR035144" ]

1

5

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1268, 3189, 35338, 123 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 40, 7, 11, 16, 40, 33, 8, 29, 39, 7, 7, 86 ]

12

true

Family

Proteasome alpha-type subunit

Proteasome_alpha-type

1

IPR023333

23,333

Proteasome B-type subunit

Proteasome_suB-type

Family

57,462

false

ATP-dependent protease complexes are present in all three kingdoms of life, where they rid the cell of misfolded or damaged proteins and control the level of certain regulatory proteins. They include the proteasome in Eukaryotes, Archaea, and Actinomycetales and the HslVU (ClpQY, clpXP) complex in other eubacteria. Gen...

[]

0

[ "PROFILE", "PANTHER" ]

[ "PS51476", "PTHR32194" ]

[ "PROTEASOME_BETA_2", "" ]

[ 51873, 54902 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.25", "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1236974", "R-BTA-1236978", "R-BTA-174084", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA-2467813", "R-BTA-2871837", "R-BTA-349425", "R-BTA-350562", "R-BTA-382556", "R-BTA-450...

[ "EC:3.4.25", "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1236974", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-174084", "REACTOME:R-BTA-174154", "REACTOME:R-BTA-174178", "REACTOME:R-BTA-174184", "REACTOME:R-BTA-187577", "REACTOME:R-BTA-195253", "REACTOME:R-BTA-202424", ...

458

[ "1e94", "1fnt", "1g0u", "1g3i", "1g3k", "1g4a", "1g4b", "1g65", "1hqy", "1ht1", "1ht2", "1iru", "1j2q", "1jd2", "1jjw", "1kyi", "1m4y", "1ned", "1ofh", "1ofi", "1pma", "1q5q", "1q5r", "1ryp", "1ya7", "1yar", "1yau", "1yyf", "1z7q", "2f16", "2fak", "2fhg"...

628

[ "PUB00000148", "PUB00000524", "PUB00001329", "PUB00004123", "PUB00005460", "PUB00011906", "PUB00014349", "PUB00014350", "PUB00030848", "PUB00080992" ]

[ "2643381", "7682410", "7697118", "1317508", "8882582", "12446803", "12646382", "12823960", "9087403", "2535672" ]

[ "The multicatalytic proteinase of mammalian cells.", "Proteasomes: multicatalytic proteinase complexes.", "Proteasomes. Multicatalytic proteinase complexes.", "Proteolysis, proteasomes and antigen presentation.", "Proteasomes: destruction as a programme.", "Eubacterial HslV and HslU subunits homologs in p...

[ 1989, 1993, 1993, 1992, 1996, 2002, 2003, 2003, 1997, 1989 ]

10

[ "IPR001353" ]

[ "IPR000243", "IPR016295", "IPR033811", "IPR035206" ]

1

4

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1396, 16375, 39320, 371 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 37, 8, 32, 26, 1, 53, 30, 7, 24, 52, 7, 7, 87 ]

13

true

Family

Proteasome B-type subunit

Proteasome_suB-type

2

IPR023334

23,334

REKLES domain

REKLES_domain

Domain

3,585

false

This entry represents the REKLES domain, found at the C-terminal of Bright/Dril1/ARID3a proteins. These proteins are B cell-specific, matrix association (or attachment) region-binding transcriptional regulator of immunoglobulin heavy chain genes and of E2F1-dependent cell cycle progression. The REKLES domain is essenti...

[]

0

[ "PROFILE" ]

[ "PS51486" ]

[ "REKLES" ]

[ 3585 ]

1

[ "REACTOME" ]

[ "R-HSA-6804116" ]

[ "REACTOME:R-HSA-6804116" ]

1

[]

0

[ "PUB00054208", "PUB00054209" ]

[ "17400556", "16507996" ]

[ "REKLES is an ARID3-restricted multifunctional domain.", "A regulated nucleocytoplasmic shuttle contributes to Bright's function as a transcriptional activator of immunoglobulin genes." ]

[ 2007, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 3580 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 31, 4, 7, 8, 7 ]

6

true

Domain

REKLES domain

REKLES_domain

6

IPR023335

23,335

ATP12 orthogonal Bundle domain superfamily

ATP12_ortho_dom_sf

Homologous_superfamily

7,287

false

This superfamily represents an orthogonal bundle domain found in mitochondrial ATPase F1 complex assembly protein ATP12 [ ] and homologue protein ATPAF2 (assembly factor 2) [ ].

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.3580.10" ]

[ "" ]

[ 7287 ]

1

[]

0

[ "2p4x", "2r31", "2r6i", "2zd2" ]

4

[ "PUB00014715", "PUB00054212" ]

[ "1826907", "11410595" ]

[ "Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase.", "Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria." ]

[ 1991, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2871, 4393, 23 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 1, 2, 3, 2, 1, 3, 8, 1, 1, 4 ]

12

true

Homologous_superfamily

ATP12 orthogonal Bundle domain superfamily

ATP12_ortho_dom_sf

2

IPR023336

23,336

RAG nonamer-binding domain

RAG_nonamer-bd_dom

Domain

9,824

false

The variable portions of immunoglobulin and T cell receptor genes are assembled in developing lymphocytes from variable (V), joining (J), and in some cases diversity (D) gene segments, which are widely separated in the genome. These segments are brought together in a highly regulated manner by a somatic site-specific r...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF12940", "PS51487" ]

[ "RAG1", "NBD" ]

[ 9035, 9761 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "3gna", "3gnb", "3jbw", "3jbx", "3jby", "4wwx", "5zdz", "5ze0", "5ze1", "5ze2", "6b40", "6cg0", "6cij", "6cik", "6cil", "6cim", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq"...

44

[ "PUB00052188", "PUB00054210", "PUB00054211", "PUB00056079", "PUB00056080", "PUB00098031", "PUB00150929" ]

[ "19396172", "8861909", "8861910", "19621044", "7642230", "24464998", "25707801" ]

[ "Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.", "RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.", "The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination.", "RAG: a rec...

[ 2009, 1996, 1996, 2009, 1995, 2014, 2015 ]

7

[]

0

null

[ "Archaeoglobus fulgidus", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1, 14, 9807, 2 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 3, 3 ]

4

true

Domain

RAG nonamer-binding domain

RAG_nonamer-bd_dom

4

IPR023337

23,337

c-Kit-binding domain

KBD

Domain

2,773

false

This entry represents the c-Kit binding domain found in metazoan Spread (Sprouty-related, EVH1 domain-containing) proteins. This domain has been shown to be necessary for Spread-1 phosphorylation and is not similar to other previously reported tyrosine kinase interacting domains, such as SH2 or c-Met binding domains [ ...

[]

0

[ "PROFILE" ]

[ "PS51488" ]

[ "KBD" ]

[ 2773 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-5658623", "R-HSA-5658442", "R-HSA-5658623", "R-HSA-6802953", "R-MMU-5658442", "R-MMU-5658623", "R-RNO-5658442", "R-RNO-5658623", "R-XTR-5658623" ]

[ "REACTOME:R-DRE-5658623", "REACTOME:R-HSA-5658442", "REACTOME:R-HSA-5658623", "REACTOME:R-HSA-6802953", "REACTOME:R-MMU-5658442", "REACTOME:R-MMU-5658623", "REACTOME:R-RNO-5658442", "REACTOME:R-RNO-5658623", "REACTOME:R-XTR-5658623" ]

9

[]

0

[ "PUB00035332", "PUB00054213" ]

[ "11493923", "12646235" ]

[ "Spred is a Sprouty-related suppressor of Ras signalling.", "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation." ]

[ 2001, 2003 ]

2

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 4, 2769 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 8, 6, 15 ]

4

true

Domain

c-Kit-binding domain

KBD

3

IPR023338

23,338

Arterivirus NSP4 peptidase domain

Arterivirus_NSP4_peptidase

Domain

1,540

false

Ths entry represents the NSP4 proteinase of arteriviruses. Arteriviruses are enveloped, positive-stranded RNA viruses and include pathogens of major economic concern to the swine- and horse-breeding industries: Equine arteritis virus (EAV). Porcine reproductive and respiratory syndrome virus (PRRSV). Mice actate dehydr...

[ "GO:0008233" ]

[ "peptidase activity" ]

[ "molecular_function" ]

1

[ "PROFILE" ]

[ "PS51493" ]

[ "AV_NSP4_PRO" ]

[ 1540 ]

1

[ "EC", "EC", "EC", "EC", "EC", "EC", "EC", "METACYC" ]

[ "2.7.7.48", "3.4.19.12", "3.4.21.-", "3.4.22.-", "3.6.4.12", "3.6.4.13", "4.6.1.-", "PWY-7884" ]

[ "EC:2.7.7.48", "EC:3.4.19.12", "EC:3.4.21.-", "EC:3.4.22.-", "EC:3.6.4.12", "EC:3.6.4.13", "EC:4.6.1.-", "METACYC:PWY-7884" ]

8

[ "1mbm", "3fan", "3fao", "5y4l" ]

4

[ "PUB00027289", "PUB00052898" ]

[ "12163505", "19646449" ]

[ "Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole.", "Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PR...

[ 2002, 2009 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Nidovirales" ]

[ 4, 2, 1534 ]

3

[]

0

true

Domain

Arterivirus NSP4 peptidase domain

Arterivirus_NSP4_peptidase

5

IPR023339

23,339

CVC domain

CVC

Domain

2,584

false

This entry represents the CVC (Chx10/Vsx-1 and ceh-10) domain, which is found in visual system homeobox proteins. Homeobox-containing genes encode transcription factors and are characterised by the homeodomain (HD), a motif that directs specific DNA binding to regulate the expression of target genes. Homeobox genes are...

[]

0

[ "PROFILE" ]

[ "PS51496" ]

[ "CVC" ]

[ 2584 ]

1

[]

0

[]

0

[ "PUB00054217", "PUB00054218", "PUB00054219" ]

[ "7789259", "11485319", "15767664" ]

[ "The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye.", "Isolation and characterization of Vsx1, a novel mouse CVC paired-like homeobox gene expressed during embryogenesis and in the retina.", "Nuclear export is evolutionarily conserved in CVC pai...

[ 1995, 2001, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Thermosphaera chiliense", "marine metagenome" ]

[ 3, 2579, 1, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 5, 5, 6, 5 ]

6

true

Domain

CVC domain

CVC

5

IPR023340

23,340

UMA domain

UMA

Domain

5,175

false

This entry represents the UMA domain, which contains a conserved proline followed by a hydrophobic residue in the N terminus and a nearly absolutely conserved glutamate at the C terminus. It is predicted to adopt an α+β fold [ ]. A key aspect of eukaryotic intracellular trafficking is the sorting of cell-surface protei...

[]

0

[ "PROFILE" ]

[ "PS51497" ]

[ "UMA" ]

[ 5175 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-917729", "R-DRE-917729", "R-HSA-162588", "R-HSA-174490", "R-HSA-917729", "R-HSA-9610379", "R-HSA-9615710", "R-MMU-917729", "R-RNO-917729" ]

[ "REACTOME:R-BTA-917729", "REACTOME:R-DRE-917729", "REACTOME:R-HSA-162588", "REACTOME:R-HSA-174490", "REACTOME:R-HSA-917729", "REACTOME:R-HSA-9610379", "REACTOME:R-HSA-9615710", "REACTOME:R-MMU-917729", "REACTOME:R-RNO-917729" ]

9

[]

0

[ "PUB00054220" ]

[ "20448139" ]

[ "UMA and MABP domains throw light on receptor endocytosis and selection of endosomal cargoes." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5175 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 18, 4, 12, 11, 18 ]

6

true

Domain

UMA domain

UMA

9

IPR023342

23,342

APO domain

APO_dom

Domain

2,828

false

This entry represents the APO domain which is found in plant APO (Accumulation of photosystem) proteins. The domain contains conserved cysteine and histidine residues [ ]. It functions as an RNA-binding domain [ ].

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF05634", "PS51499" ]

[ "APO_RNA-bind", "APO" ]

[ 2820, 2682 ]

2

[]

0

[]

0

[ "PUB00054221", "PUB00057416" ]

[ "15494558", "21421812" ]

[ "ACCUMULATION OF PHOTOSYSTEM ONE1, a member of a novel gene family, is required for accumulation of [4Fe-4S] cluster-containing chloroplast complexes and antenna proteins.", "APO1 promotes the splicing of chloroplast group II introns and harbors a plant-specific zinc-dependent RNA binding domain." ]

[ 2004, 2011 ]

2

[]

0

null

[ "Eukaryota", "Paenibacillus prosopidis" ]

[ 2827, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 18, 13, 14 ]

3

true

Domain

APO domain

APO_dom

3

IPR023343

23,343

Penicillin amidase type, domain 1

Penicillin_amidase_dom1

Homologous_superfamily

17,670

false

Penicillin amidase or penicillin acylase catalyses the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins [ ]. This superfamily represents the N-terminal structural domain of the penicillin amidase peptidases. It forms an α-hel...

[ "GO:0016811" ]

[ "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" ]

[ "molecular_function" ]

1

[ "CATHGENE3D" ]

[ "G3DSA:1.10.439.10" ]

[ "" ]

[ 17670 ]

1

[ "EC" ]

[ "3.5.1.97" ]

[ "EC:3.5.1.97" ]

1

[ "1ai4", "1ai5", "1ai6", "1ai7", "1ajn", "1ajp", "1ajq", "1cp9", "1e3a", "1fm2", "1fxh", "1fxv", "1ghd", "1gk0", "1gk1", "1gk9", "1gkf", "1gm7", "1gm8", "1gm9", "1h2g", "1jvz", "1jw0", "1jx9", "1k5q", "1k5s", "1k7d", "1kec", "1keh", "1or0", "1pnk", "1pnl"...

84

[ "PUB00000144", "PUB00025281" ]

[ "9292993", "11601852" ]

[ "Molecular cloning and analysis of the gene encoding the thermostable penicillin G acylase from Alcaligenes faecalis.", "Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism." ]

[ 1997, 2001 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 297, 16926, 167, 280 ]

4

[]

0

true

Homologous_superfamily

Penicillin amidase type, domain 1

Penicillin_amidase_dom1

8

IPR023346

23,346

Lysozyme-like domain superfamily

Lysozyme-like_dom_sf

Homologous_superfamily

296,824

false

This entry represents a lysozyme-like domain superfamily found in glycosyl hydrolases and transglycosylases. Biosynthetic peptidoglycan transglycosylases are peptidoglycan polymerases that catalyse glycan chain elongation from lipid-linked precursors [ ].

[]

0

[ "SSF" ]

[ "SSF53955" ]

[ "" ]

[ 296824 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6798695", "R-BTA-6803157", "R-CFA-6798695", "R-CFA-6803157", "R-DME-5653890", "R-GGA-5653890", "R-GGA-6798695", "R-GGA-6803157", "R-HSA-5653890", "R-HSA-6798695", "R-HSA-6803157", "R-HSA-9638771", "R-HSA-977225", "R-MMU-5653890", "R-MMU-6798695", "R-MMU-6803157", "R-RNO-679869...

[ "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-6803157", "REACTOME:R-CFA-6798695", "REACTOME:R-CFA-6803157", "REACTOME:R-DME-5653890", "REACTOME:R-GGA-5653890", "REACTOME:R-GGA-6798695", "REACTOME:R-GGA-6803157", "REACTOME:R-HSA-5653890", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-6803157", "REACTOM...

21

[ "102l", "103l", "104l", "107l", "108l", "109l", "110l", "111l", "112l", "113l", "114l", "115l", "118l", "119l", "120l", "122l", "123l", "125l", "126l", "127l", "128l", "129l", "130l", "131l", "132l", "133l", "134l", "135l", "137l", "138l", "139l", "140l"...

2,752

[ "PUB00042230" ]

[ "17347437" ]

[ "Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 36, 263006, 23925, 6883, 9, 2965 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 68, 11, 20, 31, 14, 28, 27, 37, 36, 90 ]

10

true

Homologous_superfamily

Lysozyme-like domain superfamily

Lysozyme-like_dom_sf

6

IPR023347

23,347

Lysozyme domain superfamily

Lysozyme_dom_sf

Homologous_superfamily

18,101

false

This entry represents a domain superfamily found in phage lysozyme and related proteins [ ], including Bacteriophage lambda lysozyme and Escherichia coli endolysin [ ]. Lysozyme helps to release mature phage particles from the cell wall by breaking down the peptidoglycan. The enzyme hydrolyses the 1,4-beta linkages bet...

[ "GO:0003796" ]

[ "lysozyme activity" ]

[ "molecular_function" ]

1

[ "CATHGENE3D" ]

[ "G3DSA:1.10.530.40" ]

[ "" ]

[ 18101 ]

1

[ "EC" ]

[ "3.2.1.17" ]

[ "EC:3.2.1.17" ]

1

[ "102l", "103l", "104l", "107l", "108l", "109l", "110l", "111l", "112l", "113l", "114l", "115l", "118l", "119l", "120l", "122l", "123l", "125l", "126l", "127l", "128l", "129l", "130l", "131l", "137l", "138l", "139l", "140l", "141l", "142l", "143l", "144l"...

897

[ "PUB00003216", "PUB00004082", "PUB00084188" ]

[ "3586019", "2234094", "22389108" ]

[ "Structure of bacteriophage T4 lysozyme refined at 1.7 A resolution.", "A mutant T4 lysozyme displays five different crystal conformations.", "Protein determinants of phage T4 lysis inhibition." ]

[ 1987, 1990, 2012 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3, 14033, 1418, 2505, 142 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Homologous_superfamily

Lysozyme domain superfamily

Lysozyme_dom_sf

4

IPR023349

23,349

Ammonia monooxygenase/particulate methane monooxygenase, subunit C domain superfamily

NH3_CH4_mOase_C_sf

Homologous_superfamily

475

false

This superfamily represents the structural domain of the C subunit of ammonia monooxygenase/particulate methane monooxygenase. Ammonia monooxygenase and the particulate methane monooxygenase are both integral membrane proteins, occurring in ammonia oxidisers and methanotrophs respectively, which are thought to be evolu...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.1050.50" ]

[ "" ]

[ 475 ]

1

[]

0

[ "1yew", "3chx", "3rfr", "3rgb", "4phz", "4pi0", "4pi2", "6cxh", "7ev9", "7s4h", "7s4i", "7s4j", "7s4k", "7s4l", "7s4m", "7t4o", "7t4p", "7yzy", "8oyi", "8sqw", "8sr1", "8sr2", "8sr4", "8sr5", "9cl1", "9cl2", "9cl3", "9cl4", "9cl5", "9cl6" ]

30

[ "PUB00016963", "PUB00016964", "PUB00016965" ]

[ "7590173", "12209257", "15674245" ]

[ "Evidence that particulate methane monooxygenase and ammonia monooxygenase may be evolutionarily related.", "Molecular biology and biochemistry of ammonia oxidation by Nitrosomonas europaea.", "Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane." ]

[ 1995, 2002, 2005 ]

3

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 85, 356, 34 ]

3

[]

0

true

Homologous_superfamily

Ammonia monooxygenase/particulate methane monooxygenase, subunit C domain superfamily

NH3_CH4_mOase_C_sf

5

IPR023351

23,351

YppE-like superfamily

YppE-like_sf

Homologous_superfamily

1,247

false

This superfamily represents a domain which consists of a four α-helical up-and-down bundle. It is found in a family of uncharacterised proteins [ ].

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.20.120.440", "SSF140415" ]

[ "", "" ]

[ 1213, 1245 ]

2

[]

0

[ "2a2m", "2a2o", "2ets", "2hfi", "2huj", "2im8", "6r80", "7jrq" ]

8

[ "PUB00047405" ]

[ "18324683" ]

[ "Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "marine sediment metagenome" ]

[ 1236, 7, 3, 1 ]

4

[]

0

true

Homologous_superfamily

YppE-like superfamily

YppE-like_sf

1

IPR023352

23,352

Membrane associated eicosanoid/glutathione metabolism-like domain superfamily

MAPEG-like_dom_sf

Homologous_superfamily

29,209

false

This domain is found in a widespread superfamily known as MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) [ ]. Included in this superfamily are: 5-lipoxygenase activating protein (gene FLAP), which seems to be required for the activation of 5-lipoxygenase. Leukotriene C4 synthase ( ), whic...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.20.120.550", "SSF161084" ]

[ "", "" ]

[ 28828, 29074 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.5.1", "R-BTA-156590", "R-BTA-2142688", "R-BTA-2142691", "R-BTA-2142700", "R-BTA-2162123", "R-BTA-5423646", "R-BTA-9026762", "R-BTA-9026766", "R-CFA-2162123", "R-DDI-156590", "R-DDI-2142688", "R-DDI-2142691", "R-DDI-2142700", "R-DDI-5423646", "R-DDI-9026762", "R-DDI-9026766", "R-...

[ "EC:2.5.1", "REACTOME:R-BTA-156590", "REACTOME:R-BTA-2142688", "REACTOME:R-BTA-2142691", "REACTOME:R-BTA-2142700", "REACTOME:R-BTA-2162123", "REACTOME:R-BTA-5423646", "REACTOME:R-BTA-9026762", "REACTOME:R-BTA-9026766", "REACTOME:R-CFA-2162123", "REACTOME:R-DDI-156590", "REACTOME:R-DDI-2142688"...

47

[ "2h8a", "2pno", "2q7m", "2q7r", "2uuh", "2uui", "3b29", "3dww", "3hkk", "3leo", "3pcv", "4al0", "4al1", "4bpm", "4j7t", "4j7y", "4jc7", "4jcz", "4jrz", "4nta", "4ntb", "4ntf", "4wab", "4yk5", "4yl0", "4yl1", "4yl3", "5bqg", "5bqh", "5bqi", "5hv9", "5i9k"...

50

[ "PUB00005060", "PUB00048888" ]

[ "10091672", "17600184" ]

[ "Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism.", "Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein." ]

[ 1999, 2007 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes", "uncultured Caudovirales phage", "uncultured Poseidoniia archaeon" ]

[ 13409, 15639, 159, 1, 1 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 24, 17, 1, 20, 19, 3, 3, 27, 7 ]

10

true

Homologous_superfamily

Membrane associated eicosanoid/glutathione metabolism-like domain superfamily

MAPEG-like_dom_sf

4

IPR023353

23,353

LemA-like domain superfamily

LemA-like_dom_sf

Homologous_superfamily

21,251

false

The exact molecular function of the LemA protein is uncertain. Structurally LemA consists of a four-helical bundle where helices 2 and 3 are shorter than helices 1 and 4. It is predicted to be a transmembrane protein with an extracellular N terminus [ ].

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.20.1440.20", "SSF140478" ]

[ "", "" ]

[ 20939, 20825 ]

2

[]

0

[ "2etd" ]

1

[ "PUB00009805" ]

[ "8758895" ]

[ "Identification of an H2-M3-restricted Listeria epitope: implications for antigen presentation by M3." ]

[ 1996 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 205, 20487, 41, 28, 490 ]

5

[]

0

true

Homologous_superfamily

LemA-like domain superfamily

LemA-like_dom_sf

9

IPR023355

23,355

Myotoxin/Anemone neurotoxin domain superfamily

Myo_ane_neurotoxin_sf

Homologous_superfamily

387

false

This superfamily represents the β-sheet domain found in snake myotoxin and anemone neurotoxins [ , ].

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.20.20.10" ]

[ "" ]

[ 387 ]

1

[]

0

[ "1ahl", "1apf", "1atx", "1b8w", "1bds", "1d6b", "1h5o", "1sh1", "1shi", "1wqk", "1wxn", "1z99", "1zlh", "1zli", "1zue", "1zuf", "2bds", "2h9x", "2jto", "2k2x", "2k2z", "2mn3", "2mub", "2rng", "2sh1", "3d4u", "3lms", "3osl", "4gv5", "6qbk", "6qbl", "7bwi"...

33

[ "PUB00016458", "PUB00097364" ]

[ "2566326", "24100315" ]

[ "Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing.", "Structure of the polypeptide crotamine from the Brazilian ra...

[ 1989, 2013 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 387 ]

1

[]

0

true

Homologous_superfamily

Myotoxin/Anemone neurotoxin domain superfamily

Myo_ane_neurotoxin_sf

3

IPR023356

23,356

Leucyl-tRNA synthetase, domain 3

Leu-tRNA-synth_dom3

Domain

57

false

Leucine-tRNA ligase ( ) is an alpha monomer that belongs to class Ia. The crystal structure of leucine-tRNA ligase from the hyperthermophile Thermus thermophilus has an overall architecture that is similar to that of isoleucine-tRNA ligase, except that the putative editing domain is inserted at a different position in ...

[]

0

[ "PFAM" ]

[ "PF14795" ]

[ "Leucyl-specific" ]

[ 57 ]

1

[]

0

[ "1h3n", "1obc", "1obh", "2bte", "2byt", "2v0c", "2v0g" ]

7

[ "PUB00006534" ]

[ "10811626" ]

[ "The 2 A crystal structure of leucyl-tRNA synthetase and its complex with a leucyl-adenylate analogue." ]

[ 2000 ]

1

[]

0

null

[ "Thermaceae" ]

[ 57 ]

1

[]

0

true

Domain

Leucyl-tRNA synthetase, domain 3

Leu-tRNA-synth_dom3

3

IPR023358

23,358

Peptidase M18, domain 2

Peptidase_M18_dom2

Homologous_superfamily

15,207

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0004177" ]

[ "aminopeptidase activity" ]

[ "molecular_function" ]

1

[ "CATHGENE3D" ]

[ "G3DSA:2.30.250.10" ]

[ "" ]

[ 15207 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.4.11.-", "PWY-6423", "PWY-7694", "PWY-7954" ]

[ "EC:3.4.11.-", "METACYC:PWY-6423", "METACYC:PWY-7694", "METACYC:PWY-7954" ]

4

[ "1y7e", "2glf", "2glj", "2ijz", "3var", "3vat", "3wt4", "4dyo", "4eme", "4njq", "4njr", "4oid", "4oiw", "4r8f", "5jgf", "5jh9", "5jm6", "5jm9", "6pev", "7u5h" ]

20

[ "PUB00002544", "PUB00003579" ]

[ "2651436", "7674922" ]

[ "Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae.", "Evolutionary families of metallopeptidases." ]

[ 1989, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 22, 8499, 6567, 119 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "S...

[ 8, 2, 2, 14, 8, 2, 4, 10, 2, 1, 9 ]

11

true

Homologous_superfamily

Peptidase M18, domain 2

Peptidase_M18_dom2

8

IPR023359

23,359

Dihydroorotate dehydrogenase A, chain A, domain 2

Dihydro_DH_chainA_dom2

Homologous_superfamily

1,976

false

Dihydroorotate dehydrogenase ( ) (DHOdehase) catalyses the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein. In bacteria (gene pyrD), DHOdease is located on the inner side of the cytosolic membrane. In some yeasts, such as i...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.30.26.10" ]

[ "" ]

[ 1976 ]

1

[ "EC", "METACYC" ]

[ "1.3.98.1", "PWY-7790" ]

[ "EC:1.3.98.1", "METACYC:PWY-7790" ]

2

[ "1dor", "1jqv", "1jqx", "1jrb", "1jrc", "1jub", "1jue", "1ovd", "2bsl", "2bx7", "2dor", "3oix", "4wzh", "9cb8", "9n67", "9n68", "9n6o", "9n6q" ]

18

[ "PUB00004801" ]

[ "1409592" ]

[ "Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts." ]

[ 1992 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 50, 892, 997, 7, 30 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Homologous_superfamily

Dihydroorotate dehydrogenase A, chain A, domain 2

Dihydro_DH_chainA_dom2

7

IPR023362

23,362

PH-BEACH domain

PH-BEACH_dom

Domain

22,050

false

This entry represents a domain with a fold similar to that of the PH (pleckstrin homology) domain, despite displaying little sequence homology with canonical PH domains. Furthermore, this domain is incapable of binding phospholipids [ ]. This domain is found preceding the BEACH domain in beige-like and BEACH-domain con...

[]

0

[ "PFAM", "PROFILE", "CDD" ]

[ "PF14844", "PS51783", "cd01201" ]

[ "PH_BEACH", "PH_BEACH", "PH_BEACH" ]

[ 18723, 21938, 16764 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6798695", "R-DRE-6798695", "R-HSA-112314", "R-HSA-163615", "R-HSA-2122947", "R-HSA-5626978", "R-HSA-6798695", "R-HSA-9609736", "R-MMU-5626978", "R-MMU-6798695" ]

[ "REACTOME:R-DDI-6798695", "REACTOME:R-DRE-6798695", "REACTOME:R-HSA-112314", "REACTOME:R-HSA-163615", "REACTOME:R-HSA-2122947", "REACTOME:R-HSA-5626978", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9609736", "REACTOME:R-MMU-5626978", "REACTOME:R-MMU-6798695" ]

10

[ "1mi1", "1t77" ]

2

[ "PUB00031364" ]

[ "15554694" ]

[ "Crystal structure of the PH-BEACH domains of human LRBA/BGL." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 22046 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 29, 6, 111, 11, 51, 31, 1, 14, 42, 1, 1, 37 ]

12

true

Domain

PH-BEACH domain

PH-BEACH_dom

9

IPR023364

23,364

Trans-sialidase, domain 3

Trans_sialidase_dom3

Homologous_superfamily

982

false

This entry represents a β-barrel domain found in bacterial trans-sialidase NanA, NanB and in the leech sialidase [ , , ]. Both act as intramolecular trans-sialidases. Trans-sialidases are responsible for the transfer of previously cleaved sialic acid to other glyconjugates.

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.40.220.10" ]

[ "" ]

[ 982 ]

1

[ "EC" ]

[ "3.2.1.18" ]

[ "EC:3.2.1.18" ]

1

[ "1sli", "1sll", "2bf6", "2jkb", "2sli", "2vk5", "2vk6", "2vk7", "2vvz", "2vw0", "2vw1", "2vw2", "2w20", "2ya4", "2ya5", "2ya6", "2ya7", "2ya8", "3h71", "3h72", "3h73", "3sli", "4foq", "4fov", "4fow", "4foy", "4fp2", "4fp3", "4fpc", "4fpe", "4fpf", "4fpg"...

95

[ "PUB00014147", "PUB00049929", "PUB00052248" ]

[ "9878409", "18835278", "19284989" ]

[ "The 1.8 A structures of leech intramolecular trans-sialidase complexes: evidence of its enzymatic mechanism.", "Crystal structure of the NanB sialidase from Streptococcus pneumoniae.", "Crystal structures of respiratory pathogen neuraminidases." ]

[ 1999, 2008, 2009 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 978, 3, 1 ]

3

[]

0

true

Homologous_superfamily

Trans-sialidase, domain 3

Trans_sialidase_dom3

2

IPR023365

23,365

Sortase domain superfamily

Sortase_dom-sf

Homologous_superfamily

35,738

false

This superfamily represents the β barrel structural domain found in sortases, which are cysteine transpeptidases involved in protein sorting activities.

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:2.40.260.10", "SSF63817" ]

[ "", "" ]

[ 35708, 35275 ]

2

[ "EC" ]

[ "3.4.22.-" ]

[ "EC:3.4.22.-" ]

1

[ "1ija", "1ng5", "1qwz", "1qx6", "1qxa", "1rz2", "1t2o", "1t2p", "1t2w", "2cz4", "2kid", "2kw8", "2ln7", "2mlm", "2oqw", "2oqz", "2rui", "2w1j", "2w1k", "2wts", "2xwg", "3fn5", "3fn6", "3fn7", "3g66", "3g69", "3o0p", "3psq", "3rbi", "3rbj", "3rbk", "3rcc"...

86

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomada group", "Viruses", "unclassified sequences" ]

[ 35294, 15, 81, 3, 345 ]

5

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Homologous_superfamily

Sortase domain superfamily

Sortase_dom-sf

4

IPR023366

23,366

ATP synthase subunit alpha, N-terminal domain-like superfamily

ATP_synth_asu-like_sf

Homologous_superfamily

85,815

false

In F-ATPases, there are three copies each of the alpha and beta subunits that form the catalytic core of the F1 complex, while the remaining F1 subunits (gamma, delta, epsilon) form part of the stalks. There is a substrate-binding site on each of the alpha and beta subunits, those on the beta subunits being catalytic, ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.40.30.20" ]

[ "" ]

[ 85815 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "7.1.2.2", "PWY-7980", "R-BTA-1222556", "R-BTA-77387", "R-BTA-917977", "R-BTA-9639288", "R-BTA-983712", "R-CEL-1222556", "R-CEL-163210", "R-CEL-77387", "R-CEL-8949613", "R-CEL-917977", "R-CEL-9639288", "R-CEL-983712", "R-CEL-9837999", "R-DDI-1222556", "R-DDI-77387", "R-DDI-917977",...

[ "EC:7.1.2.2", "METACYC:PWY-7980", "REACTOME:R-BTA-1222556", "REACTOME:R-BTA-77387", "REACTOME:R-BTA-917977", "REACTOME:R-BTA-9639288", "REACTOME:R-BTA-983712", "REACTOME:R-CEL-1222556", "REACTOME:R-CEL-163210", "REACTOME:R-CEL-77387", "REACTOME:R-CEL-8949613", "REACTOME:R-CEL-917977", "REACT...

65

[ "1bmf", "1cow", "1e1q", "1e1r", "1e79", "1efr", "1fx0", "1h8e", "1h8h", "1hze", "1i18", "1i8d", "1kmh", "1kzl", "1mab", "1nbm", "1ohh", "1pkv", "1qo1", "1sky", "1v0e", "1v0f", "1vdz", "1w0j", "1w0k", "2ck3", "2f43", "2hld", "2jdi", "2jiz", "2jj1", "2jj2"...

505

[ "PUB00020611", "PUB00020612", "PUB00025941" ]

[ "12745923", "12885621", "11377200" ]

[ "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review).", "The unbinding of ATP from F1-ATPase.", "Crystal structure of riboflavin synthase." ]

[ 2003, 2003, 2001 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1423, 52134, 30532, 553, 1173 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 21, 2, 3, 9, 2, 11, 7, 3, 23, 10, 3, 3, 28 ]

13

true

Homologous_superfamily

ATP synthase subunit alpha, N-terminal domain-like superfamily

ATP_synth_asu-like_sf

8

IPR023367

23,367

Peptidase M42, domain 2

Peptidase_M42_dom2

Homologous_superfamily

18,553

false

This entry represents the β barrel structural domain (sometimes annotated as domain 2) found in bacterial M42 peptidases.

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.40.30.40" ]

[ "" ]

[ 18553 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.4.11.-", "PWY-6423", "PWY-7694", "PWY-7954" ]

[ "EC:3.4.11.-", "METACYC:PWY-6423", "METACYC:PWY-7694", "METACYC:PWY-7954" ]

4

[ "1vhe", "1vho", "1xfo", "1y0r", "1y0y", "1ylo", "2cf4", "2fvg", "2gre", "2pe3", "2wyr", "2wzn", "3isx", "3kl9", "4p6y", "4wwv", "4x8i", "5ds0", "5l6z", "5ne6", "5ne7", "5ne8", "5ne9", "6f3k", "6nw5", "6r8n" ]

26

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine phage" ]

[ 1104, 17240, 21, 187, 1 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 3 ]

2

true

Homologous_superfamily

Peptidase M42, domain 2

Peptidase_M42_dom2

2

IPR023368

23,368

Uncharacterised protein family UPF0066, conserved site

UPF0066_cons_site

Conserved_site

6,811

false

This conserved site is found in proteins belonging to the uncharacterised protein family UPF0066. It is found in the central part of the tsaA-like domain ( ).

[]

0

[ "PROSITE" ]

[ "PS01318" ]

[ "TSAA_1" ]

[ 6811 ]

1

[]

0

[ "1xqb", "2nv4", "7btu", "7btz", "7bu1" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 399, 5857, 490, 65 ]

4

[ "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 2, 5 ]

4

true

Conserved_site

Uncharacterised protein family UPF0066, conserved site

UPF0066_cons_site

3

IPR023370

23,370

TrmO-like, N-terminal domain

TrmO-like_N

Domain

12,878

false

TrmO (also known as TsaA or YaeB) is a RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. It has a unique single-sheeted β-barrel structure and represent a new category of AdoMet-dependent methyltransferases [ ]. The following uncharacterised proteins have been shown to be e...

[]

0

[ "PFAM", "PROFILE", "NCBIFAM", "CDD" ]

[ "PF01980", "PS51668", "TIGR00104", "cd09281" ]

[ "TrmO_N", "TSAA_2", "tRNA_TsaA", "UPF0066" ]

[ 12749, 12861, 10179, 11794 ]

4

[]

0

[ "1xqb", "2nv4", "3okx", "7btu", "7btz", "7bu1" ]

6

[ "PUB00086552" ]

[ "25063302" ]

[ "Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 780, 9465, 2435, 198 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 2, 3, 1, 7, 2, 3, 5, 13 ]

9

true

Domain

TrmO-like, N-terminal domain

TrmO-like_N

6

IPR023372

23,372

Restriction endonuclease, type II, EcoRII, N-terminal

Rest_endonuc_II_EcoRII_N

Domain

703

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[]

0

[ "PFAM" ]

[ "PF09217" ]

[ "EcoRII-N" ]

[ 703 ]

1

[]

0

[ "1na6", "3hqf" ]

2

[ "PUB00029018", "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "14659759", "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Crystal structure of type IIE restriction endonuclease EcoRII reveals an autoinhibition mechanism by a novel effector-binding fold.", "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relation...

[ 2004, 2005, 2003, 2002, 2001, 2004, 2003 ]

7

[]

0

null

[ "Bacteria", "Cyprideis torosa", "Methanohalophilus portucalensis", "metagenomes" ]

[ 695, 1, 2, 5 ]

4

[]

0

true

Domain

Restriction endonuclease, type II, EcoRII, N-terminal

Rest_endonuc_II_EcoRII_N

1

IPR023373

23,373

YmcC-like superfamily

YmcC_sf

Homologous_superfamily

3,035

false

This superfamily represents the β-barrel structural domain found in YmcC-related proteins, which belong to the DUF2886 family.

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:2.40.360.10", "SSF159270" ]

[ "", "" ]

[ 3027, 3032 ]

2

[]

0

[ "2in5" ]

1

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 3017, 2, 16 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Homologous_superfamily

YmcC-like superfamily

YmcC_sf

3

IPR023374

23,374

AttH-like domain superfamily

AttH-like_dom_sf

Homologous_superfamily

6,142

false

This superfamily represents a β barrel domain found in bacterial AttH proteins, as well as in survival factors, such as survival factor 1 (Svf1) .

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.40.370.10" ]

[ "" ]

[ 6142 ]

1

[]

0

[ "2ich", "7a0q", "7a0t" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 36, 4842, 1216, 48 ]

4

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1 ]

1

true

Homologous_superfamily

AttH-like domain superfamily

AttH-like_dom_sf

6

IPR023375

23,375

Acetoacetate decarboxylase domain superfamily

ADC_dom_sf

Homologous_superfamily

14,623

false

Acetoacetate decarboxylase (ADC) is involved in solventogenesis in certain bacteria, which occurs at the end of the exponential growth phase when there is a metabolic switch from classical sugar fermentation with the production of acetate and butyrate to the re-internalisation and oxidation of these acids to acetate an...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:2.40.400.10", "SSF160104" ]

[ "", "" ]

[ 12967, 14513 ]

2

[ "EC", "METACYC", "METACYC" ]

[ "4.1.1.4", "PWY-6588", "PWY-6876" ]

[ "EC:4.1.1.4", "METACYC:PWY-6588", "METACYC:PWY-6876" ]

3

[ "3bgt", "3bh2", "3bh3", "3c8w", "3cmb", "4jm3", "4jmc", "4jmd", "4jme", "4zbo", "4zbt", "5upb", "6eej" ]

13

[ "PUB00014916", "PUB00014917" ]

[ "11824611", "10972834" ]

[ "Changes in protein synthesis and identification of proteins specifically induced during solventogenesis in Clostridium acetobutylicum.", "Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia." ]

[ 2002, 2000 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "uncultured virus" ]

[ 700, 10500, 3204, 218, 1 ]

5

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 3, 9 ]

3

true

Homologous_superfamily

Acetoacetate decarboxylase domain superfamily

ADC_dom_sf

7

IPR023376

23,376

YqcC-like domain

YqcC-like_dom

Domain

3,747

false

This entry represents the structural domain found in the N-terminal of some tRNA pseudouridine synthase C proteins, as well as other uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF04287" ]

[ "DUF446" ]

[ 3747 ]

1

[]

0

[ "2hgk" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3730, 4, 13 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

YqcC-like domain

YqcC-like_dom

5

IPR023378

23,378

YheA/YmcA-like domain superfamily

YheA/YmcA-like_dom_sf

Homologous_superfamily

8,573

false

This domain superfamily is found in a number of proteins including YlbF and YmcA, which are involved in the formation of biofilms [ ].

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.20.1500.10", "SSF158622" ]

[ "", "" ]

[ 8500, 8568 ]

2

[]

0

[ "2iaz", "2oee", "2oeq", "2pih", "6prh", "6prk" ]

6

[ "PUB00043614" ]

[ "15175311" ]

[ "Genes involved in formation of structured multicellular communities by Bacillus subtilis." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Moazamivirus", "metagenomes" ]

[ 8153, 32, 343, 2, 43 ]

5

[]

0

true

Homologous_superfamily

YheA/YmcA-like domain superfamily

YheA/YmcA-like_dom_sf

6

IPR023379

23,379

BART domain

BART_dom

Domain

4,694

false

This domain is found in ADP-ribosylation factor-like 2 (ARF2) binding protein, also known as BART. BART binds specifically to ARF2.GTP with a high affinity. However, it does not bind to ARF2.GDP. It is thought that this specific interaction is due to BART being the first identified ARF2-specific effector. The function ...

[]

0

[ "PFAM" ]

[ "PF11527" ]

[ "ARL2_Bind_BART" ]

[ 4694 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-83936", "R-DRE-83936", "R-HSA-83936", "R-MMU-83936", "R-RNO-83936", "R-XTR-83936" ]

[ "REACTOME:R-BTA-83936", "REACTOME:R-DRE-83936", "REACTOME:R-HSA-83936", "REACTOME:R-MMU-83936", "REACTOME:R-RNO-83936", "REACTOME:R-XTR-83936" ]

6

[ "2k0s", "2k9a", "3doe", "3dof", "4zi2", "4zi3" ]

6

[ "PUB00051437", "PUB00053516", "PUB00053517", "PUB00088519" ]

[ "19368893", "10488091", "11809823", "26455799" ]

[ "Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.", "The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization.", "ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter.", "T...

[ 2009, 1999, 2002, 2015 ]

4

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 4692, 2 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 2, 8, 5, 13 ]

6

true

Domain

BART domain

BART_dom

3

IPR023380

23,380

DsbB-like superfamily

DsbB-like_sf

Homologous_superfamily

15,784

false

Disulphide bonds contribute to folding, maturation, stability, and regulation of proteins, in particular those localized out of the cytosol. Oxidation of selected pairs of cysteines to disulphide in vivo requires cellular factors present in the bacterial periplasmic space or in the endoplasmic reticulum of eukaryotic c...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.20.1550.10", "SSF158442" ]

[ "", "" ]

[ 15652, 15779 ]

2

[]

0

[ "2hi7", "2k73", "2k74", "2leg", "2ltq", "2zup", "2zuq", "3e9j", "6wvf" ]

9

[ "PUB00008228", "PUB00008229", "PUB00014003", "PUB00041412", "PUB00054232" ]

[ "8430071", "7957076", "12524212", "17110337", "12415301" ]

[ "A pathway for disulfide bond formation in vivo.", "Two cysteines in each periplasmic domain of the membrane protein DsbB are required for its function in protein disulfide bond formation.", "Protein disulfide bond formation in prokaryotes.", "Crystal structure of the DsbB-DsbA complex reveals a mechanism of ...

[ 1993, 1994, 2003, 2006, 2002 ]

5

[]

0

null

[ "Archaea", "Bacillus phage SPbeta", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 187, 1, 15395, 18, 183 ]

5

[ "Escherichia coli (strain K12)", "Zea mays" ]

[ 1, 1 ]

2

true

Homologous_superfamily

DsbB-like superfamily

DsbB-like_sf

9

IPR023381

23,381

YP001051499.1-like domain superfamily

YP001051499.1-like_dom_sf

Homologous_superfamily

2,859

false

This domain superfamily is found in a family of uncharacterised proteins including protein YP_001051499.1 from Shewanella baltica.

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.1590.10" ]

[ "" ]

[ 2859 ]

1

[]

0

[ "2q9r", "3f7c" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2847, 7, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Homologous_superfamily

YP001051499.1-like domain superfamily

YP001051499.1-like_dom_sf

3

IPR023382

23,382

tRNA-specific 2-thiouridylase MnmA-like, central domain superfamily

MnmA-like_central_sf

Homologous_superfamily

29,971

false

This entry represents the central PRC-barrel domain of tRNA-specific 2-thiouridylase MnmA and similar proteins from bacteria and eukaryotes. MnmA catalyses the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s2U34 [ , ].

[ "GO:0016783" ]

[ "sulfurtransferase activity" ]

[ "molecular_function" ]

1

[ "CATHGENE3D" ]

[ "G3DSA:2.30.30.280" ]

[ "" ]

[ 29971 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME" ]

[ "2.8.1.13", "PWY-7887", "PWY-7892", "R-HSA-6787450" ]

[ "EC:2.8.1.13", "METACYC:PWY-7887", "METACYC:PWY-7892", "REACTOME:R-HSA-6787450" ]

4

[ "2der", "2det", "2deu", "2hma" ]

4

[ "PUB00017420", "PUB00040232" ]

[ "3298234", "16871210" ]

[ "Transfer RNA(5-methylaminomethyl-2-thiouridine)-methyltransferase from Escherichia coli K-12 has two enzymatic activities.", "Snapshots of tRNA sulphuration via an adenylated intermediate." ]

[ 1987, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 26243, 3158, 570 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (s...

[ 6, 1, 2, 2, 1, 4, 1, 4, 3, 1, 1, 6 ]

12

true

Homologous_superfamily

tRNA-specific 2-thiouridylase MnmA-like, central domain superfamily

MnmA-like_central_sf

5

IPR023383

23,383

Ferredoxin, chloroplast transit peptide

Ferredoxin_transit_pept

Domain

17

false

This entry represent the N-terminal transit peptide of a number of algal petF genes. The peptide is removed during transit into the chloroplast lumen.

[]

0

[ "PFAM" ]

[ "PF11591" ]

[ "2Fe-2S_Ferredox" ]

[ 17 ]

1

[]

0

[ "1fct", "7wzn" ]

2

[ "PUB00028492", "PUB00054235" ]

[ "8174712", "17660315" ]

[ "NMR structures of ferredoxin chloroplastic transit peptide from Chlamydomonas reinhardtii promoted by trifluoroethanol in aqueous solution.", "Atomic resolution modeling of the ferredoxin:[FeFe] hydrogenase complex from Chlamydomonas reinhardtii." ]

[ 1994, 2007 ]

2

[]

0

null

[ "Chlamydomonadales" ]

[ 17 ]

1

[]

0

true

Domain

Ferredoxin, chloroplast transit peptide

Ferredoxin_transit_pept

7

IPR023384

23,384

Bacteriocin, class IIa, conserved site

Bacteriocin_IIa_CS

Conserved_site

195

false

Many Gram-positive bacteria produce ribosomally synthesized antimicrobial peptides, often termed bacteriocins. One important and well studied class of bacteriocins is the class IIa or pediocin-like bacteriocins produced by lactic acid bacteria. All class IIa bacteriocins are produced by food-associated strains, isolate...

[]

0

[ "PROSITE" ]

[ "PS60030" ]

[ "BACTERIOCIN_IIA" ]

[ 195 ]

1

[]

0

[ "1cw5", "1cw6", "1og7", "1ohm", "1ohn", "1ry3", "2a2b", "2leu", "2n4k", "3leu", "5ukz", "7vly", "7xno", "7xtg" ]

14

[ "PUB00033828", "PUB00033829", "PUB00033830" ]

[ "16232543", "15611086", "16059970" ]

[ "Class IIa bacteriocins from lactic acid bacteria: antibacterial activity and food preservation.", "The C-terminal domain of pediocin-like antimicrobial peptides (class IIa bacteriocins) is involved in specific recognition of the C-terminal part of cognate immunity proteins and in determining the antimicrobial sp...

[ 1999, 2005, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "uncultured prokaryote" ]

[ 187, 7, 1 ]

3

[]

0

true

Conserved_site

Bacteriocin, class IIa, conserved site

Bacteriocin_IIa_CS

4

IPR023385

23,385

YopX-like, C-terminal

YopX-like_C

Homologous_superfamily

3,333

false

This superfamily represents the β barrel domain found in bacterial YopX and related proteins. It is found towards the C terminus.

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.30.30.290" ]

[ "" ]

[ 3333 ]

1

[]

0

[ "2ox7", "2p84", "2qyz" ]

3

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "Opisthokonta", "Viruses", "metagenomes" ]

[ 2489, 5, 4, 580, 255 ]

5

[]

0

true

Homologous_superfamily

YopX-like, C-terminal

YopX-like_C

5

IPR023387

23,387

DUF1653-like domain

DUF1653-like_dom

Domain

5,055

false

This entry represents the structural domain found in DUF1653, a protein family of unknown function.

[]

0

[ "PFAM" ]

[ "PF07866" ]

[ "DUF1653" ]

[ 5055 ]

1

[]

0

[ "3be3" ]

1

[]

0

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 4918, 2, 6, 71, 58 ]

5

[]

0

true

Domain

DUF1653-like domain

DUF1653-like_dom

9

IPR023388

23,388

Bacteriocin class IIa domain superfamily

Bacteriocin_IIa_dom_sf

Homologous_superfamily

252

false

This superfamily represents a domain found in class II bacteriocins. It consists of a well-defined central helical structure and a disordered N terminus, as described for carnobacteriocin B2, a type IIa bacteriocin [ ].

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.5.130" ]

[ "" ]

[ 252 ]

1

[]

0

[ "1cw5", "1cw6", "1og7", "1ohm", "1ohn", "1ry3", "2a2b", "2leu", "2ljq", "2ljt", "2n4k", "3leu", "5ukz", "7vly", "7xno", "7xtg" ]

16

[ "PUB00021358" ]

[ "10569926" ]

[ "Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "uncultured prokaryote" ]

[ 250, 2 ]

2

[]

0

true

Homologous_superfamily

Bacteriocin class IIa domain superfamily

Bacteriocin_IIa_dom_sf

9

IPR023390

23,390

Bacteriophage M13, G8P, capsid domain superfamily

Phage_M13_G8P_capsid_dom_sf

Homologous_superfamily

178

false

This superfamily represents the capsid domain of the Inoviridae. The type example is bacteriophage M13 Gp8 (capsid or major coat protein); which forms the baseplate structural protein. It consists largely of an α-helix with a slight curve [ , ].

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.5.80" ]

[ "" ]

[ 178 ]

1

[]

0

[ "1fdm", "1hgv", "1hgz", "1hh0", "1ifd", "1ifi", "1ifj", "1ifk", "1ifl", "1mzt", "1nh4", "2c0w", "2c0x", "2cpb", "2cps", "2hi5", "2mjz", "6a7f", "8b3o", "8b3p", "8b3q", "8ch5", "8ixj", "8ixk", "8ixl", "8jwt", "8jww", "8jwx" ]

28

[ "PUB00010511", "PUB00028619" ]

[ "8289247", "11371161" ]

[ "Molecular models and structural comparisons of native and mutant class I filamentous bacteriophages Ff (fd, f1, M13), If1 and IKe.", "The protein capsid of filamentous bacteriophage PH75 from Thermus thermophilus." ]

[ 1994, 2001 ]

2

[]

0

null

[ "Bacteria", "Tubulavirales", "ecological metagenomes" ]

[ 154, 21, 3 ]

3

[]

0

true

Homologous_superfamily

Bacteriophage M13, G8P, capsid domain superfamily

Phage_M13_G8P_capsid_dom_sf

2

IPR023391

23,391

Protein translocase SecE domain superfamily

Prot_translocase_SecE_dom_sf

Homologous_superfamily

5,385

false

The Sec61 complex (eukaryotes) or SecY complex (prokaryotes) forms a conserved heterotrimeric integral membrane protein complex and forms a protein-conducting channel that allows polypeptides to be transferred across (or integrated into) the endoplasmic reticulum (eukaryotes) or across the cytoplasmic membrane (prokary...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.20.5.820", "SSF103456" ]

[ "", "" ]

[ 5368, 5235 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9609523", "R-CEL-9609523", "R-CFA-9609523", "R-DDI-9609523", "R-DME-9609523", "R-HSA-1236974", "R-HSA-1799339", "R-HSA-9609523", "R-MMU-9609523", "R-SCE-9609523", "R-SPO-9609523" ]

[ "REACTOME:R-BTA-9609523", "REACTOME:R-CEL-9609523", "REACTOME:R-CFA-9609523", "REACTOME:R-DDI-9609523", "REACTOME:R-DME-9609523", "REACTOME:R-HSA-1236974", "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-9609523", "REACTOME:R-MMU-9609523", "REACTOME:R-SCE-9609523", "REACTOME:R-SPO-9609523" ]

11

[ "1rh5", "1rhz", "2ww9", "2wwa", "2wwb", "2yxq", "2yxr", "3bo0", "3bo1", "3dkn", "3j7q", "3j7r", "3jc2", "3mp7", "4cg5", "4cg6", "4cg7", "4v4n", "4v7i", "5a6u", "6ftg", "6fti", "6ftj", "6n3q", "6nd1", "6r7q", "6w6l", "6z3t", "7aft", "7kah", "7kai", "7kaj"...

69

[ "PUB00022601", "PUB00028068" ]

[ "14661030", "11597451" ]

[ "X-ray structure of a protein-conducting channel.", "The Sec protein-translocation pathway." ]

[ 2004, 2001 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 867, 18, 4468, 32 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 1, 6, 1, 4, 1, 6, 11, 1, 1, 8 ]

12

true

Homologous_superfamily

Protein translocase SecE domain superfamily

Prot_translocase_SecE_dom_sf

5

IPR023392

23,392

Mitochondrial outer membrane translocase complex, Tom20 domain superfamily

Tom20_dom_sf

Homologous_superfamily

4,109

false

The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of ...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.20.960.10", "SSF47157" ]

[ "", "" ]

[ 4085, 4099 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5205685", "R-BTA-5689880", "R-CEL-5205685", "R-CEL-5689880", "R-DRE-5205685", "R-DRE-5689880", "R-HSA-1268020", "R-HSA-5205685", "R-HSA-5689880", "R-MMU-5205685", "R-MMU-5689880", "R-RNO-5205685", "R-RNO-5689880", "R-SCE-5205685", "R-SPO-5205685", "R-SPO-5689880", "R-XTR-52056...

[ "REACTOME:R-BTA-5205685", "REACTOME:R-BTA-5689880", "REACTOME:R-CEL-5205685", "REACTOME:R-CEL-5689880", "REACTOME:R-DRE-5205685", "REACTOME:R-DRE-5689880", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-5205685", "REACTOME:R-HSA-5689880", "REACTOME:R-MMU-5205685", "REACTOME:R-MMU-5689880", "REACTOM...

18

[ "1om2", "2v1s", "2v1t", "3awr", "3ax2", "3ax3", "3ax5", "5az6", "5az7", "5az8", "5az9", "7vby", "7vc9", "8uy3", "8xva", "9eih", "9eii", "9eij", "9i7s", "9i7t", "9j79", "9j7a", "9j7b", "9jce" ]

24

[ "PUB00022363", "PUB00054236", "PUB00054237", "PUB00054238", "PUB00054239" ]

[ "10721992", "9442867", "8223428", "9774109", "10519552" ]

[ "Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20.", "Mitochondrial preprotein translocase.", "Functional cooperation of mitochondrial protein import receptors in yeast.", "Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins [see c...

[ 2000, 1997, 1993, 1998, 1999 ]

5

[]

0

null

[ "Eukaryota", "Pseudogemmatithrix spongiicola" ]

[ 4108, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 3, 4, 2, 4, 1, 6, 1, 1 ]

9

true

Homologous_superfamily

Mitochondrial outer membrane translocase complex, Tom20 domain superfamily

Tom20_dom_sf

2

IPR023393

23,393

START-like domain superfamily

START-like_dom_sf

Homologous_superfamily

285,464

false

This superfamily represents an α/β sandwich structural domain found in a wide variety of protein families, including STAR-related lipid transfer proteins and homeobox-leucine zipper proteins. START (StAR-related lipid-transfer) is a lipid-binding domain in StAR, HD-ZIP and signalling proteins [ ]. StAR (Steroidogenic A...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.530.20" ]

[ "" ]

[ 285464 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1483191", "R-BTA-1483196", "R-BTA-159418", "R-BTA-1660661", "R-BTA-196108", "R-BTA-77289", "R-BTA-9837999", "R-DDI-1483196", "R-DME-1483226", "R-DME-611105", "R-DME-9864848", "R-DRE-1660661", "R-DRE-196108", "R-DRE-611105", "R-DRE-9837999", "R-DRE-9864848", "R-GGA-196108", "...

[ "REACTOME:R-BTA-1483191", "REACTOME:R-BTA-1483196", "REACTOME:R-BTA-159418", "REACTOME:R-BTA-1660661", "REACTOME:R-BTA-196108", "REACTOME:R-BTA-77289", "REACTOME:R-BTA-9837999", "REACTOME:R-DDI-1483196", "REACTOME:R-DME-1483226", "REACTOME:R-DME-611105", "REACTOME:R-DME-9864848", "REACTOME:R-D...

66

[ "1b6f", "1btv", "1bv1", "1e09", "1em2", "1fm4", "1fsk", "1h2o", "1icx", "1ifv", "1jss", "1kcm", "1llt", "1ln1", "1ln2", "1ln3", "1qmr", "1t17", "1t27", "1tw0", "1txc", "1uw5", "1vjh", "1x53", "1xdf", "1xfs", "1xn5", "1xn6", "1xuv", "1z94", "1zxf", "2a1l"...

399

[ "PUB00002877", "PUB00005851", "PUB00007207", "PUB00007208" ]

[ "7961770", "10322415", "11276083", "10802740" ]

[ "The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR).", "START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins.", "Adaptations of the helix-...

[ 1994, 1999, 2001, 2000 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "Viruses", "unclassified sequences" ]

[ 3101, 164875, 115711, 1, 18, 1758 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 401, 17, 101, 25, 1, 119, 93, 4, 160, 107, 2, 3, 377 ]

13

true

Homologous_superfamily

START-like domain superfamily

START-like_dom_sf

2

IPR023394

23,394

Sec7, C-terminal domain superfamily

Sec7_C_sf

Homologous_superfamily

44,076

false

The Sec7 domain was named after the first protein found to contain such a region [ ]. It has been shown to be linked with guanine nucleotide exchange function [ , ]. The 3D structure of the domain displays several α-helices [ ]. It was found to be associated with other domains involved in guanine nucleotide exchange (e...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.1000.11" ]

[ "" ]

[ 44076 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-199992", "R-CEL-6807878", "R-CEL-6811434", "R-HSA-199992", "R-HSA-390471", "R-HSA-5620916", "R-HSA-6807878", "R-HSA-6811434", "R-HSA-6811438", "R-HSA-9768919", "R-MMU-199992", "R-MMU-5620916", "R-MMU-6807878", "R-MMU-6811434", "R-MMU-6811438", "R-RNO-6811438", "R-SCE-199992", ...

[ "REACTOME:R-CEL-199992", "REACTOME:R-CEL-6807878", "REACTOME:R-CEL-6811434", "REACTOME:R-HSA-199992", "REACTOME:R-HSA-390471", "REACTOME:R-HSA-5620916", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811434", "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-9768919", "REACTOME:R-MMU-199992", "REACTOME:R-...

26

[ "1bc9", "1ku1", "1pbv", "1r8m", "1r8q", "1r8s", "1re0", "1s9d", "1xsz", "1xt0", "2r09", "2r0d", "3l8n", "3ltl", "3swv", "4a4p", "4c0a", "4c7p", "4d7q", "4d7r", "4jmi", "4jmo", "4jwl", "4jxh", "4l5m", "4oiy", "4z21", "5nlv", "5nly", "6bbp", "6bbq", "6fae"...

43

[ "PUB00005683", "PUB00005779", "PUB00005806", "PUB00005826", "PUB00005838" ]

[ "3042778", "9072969", "9442017", "9653114", "9868368" ]

[ "SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast Golgi apparatus.", "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains.", "Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide ...

[ 1988, 1997, 1998, 1998, 1998 ]

5

[]

0

null

[ "Eukaryota", "Pseudomonadota", "metagenomes" ]

[ 44036, 37, 3 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 38, 9, 146, 14, 80, 64, 5, 22, 79, 5, 6, 215 ]

12

true

Homologous_superfamily

Sec7, C-terminal domain superfamily

Sec7_C_sf

4

IPR023395

23,395

Mitochondrial carrier protein domain superfamily

MCP_dom_sf

Homologous_superfamily

216,008

false

This superfamily represents a structural domain found in mitochondrial carrier proteins. A variety of substrate carrier proteins involved in energy transfer are found in the inner mitochondrial membrane or are integral to the membranes of other eukaryotic organelles such as the peroxisome [ , , , , ]. Such proteins inc...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.50.40.10", "SSF103506" ]

[ "", "" ]

[ 214918, 215942 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1268020", "R-BTA-166187", "R-BTA-167826", "R-BTA-196819", "R-BTA-352230", "R-BTA-425393", "R-BTA-428643", "R-BTA-71064", "R-BTA-83936", "R-BTA-9837999", "R-BTA-9856872", "R-CEL-1614517", "R-CEL-200425", "R-CEL-428643", "R-CEL-8963693", "R-CEL-9856872", "R-DDI-1268020", "R-DD...

[ "REACTOME:R-BTA-1268020", "REACTOME:R-BTA-166187", "REACTOME:R-BTA-167826", "REACTOME:R-BTA-196819", "REACTOME:R-BTA-352230", "REACTOME:R-BTA-425393", "REACTOME:R-BTA-428643", "REACTOME:R-BTA-71064", "REACTOME:R-BTA-83936", "REACTOME:R-BTA-9837999", "REACTOME:R-BTA-9856872", "REACTOME:R-CEL-16...

135

[ "1okc", "2c3e", "2lck", "4c9g", "4c9h", "4c9j", "4c9q", "6gci", "7w5z", "8b6h", "8bqs", "8g8w", "8gym", "8gzu", "8hbv", "8hbw", "8j1n", "9fzq" ]

18

[ "PUB00001005", "PUB00001675", "PUB00003301", "PUB00005084", "PUB00005351", "PUB00005407", "PUB00029479", "PUB00101069" ]

[ "8325039", "8206158", "8487299", "8140286", "2158156", "8291088", "14603310", "21785437" ]

[ "The mitochondrial carrier family of transport proteins: structural, functional, and evolutionary relationships.", "Mitochondrial carrier proteins.", "Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential.", "Expansion of the mitochondrial carrie...

[ 1993, 1994, 1993, 1993, 1990, 1993, 2003, 2011 ]

8

[]

0

null

[ "Bacteria", "Candidatus Nitrosocosmicus arcticus", "Eukaryota", "Viruses", "metagenomes" ]

[ 146, 1, 215714, 74, 73 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 270, 49, 158, 119, 273, 169, 40, 204, 239, 35, 24, 414 ]

12

true

Homologous_superfamily

Mitochondrial carrier protein domain superfamily

MCP_dom_sf

5

IPR023397

23,397

S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain superfamily

SAM-dep_MeTrfase_MraW_recog

Homologous_superfamily

29,892

false

This domain superfamily is found inserted into bacterial SAM-dependent methyltransferases and is thought to be involved in methyl acceptor selectivity. In contrast with recognition domains found in other methyltransferases, it is inserted into the centre of the protein sequence and has an α orthogonal structure rather ...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:1.10.150.170", "SSF81799" ]

[ "", "" ]

[ 29518, 29828 ]

2

[ "EC" ]

[ "2.1.1.199" ]

[ "EC:2.1.1.199" ]

1

[ "1m6y", "1n2x", "1wg8", "3tka", "6sg9", "6sga", "6sgb", "7pnv", "7pnx", "7pny", "7pnz", "8ipi", "8ipk", "8ipl", "8ipm", "8qrl", "9g5c", "9g5d", "9hny" ]

19

[ "PUB00027239" ]

[ "12824489" ]

[ "Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences", "uncultured marine group II/III euryarchaeote KM3_94_C01" ]

[ 26360, 2900, 1, 630, 1 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 13, 1, 1, 3, 2, 3, 3, 5 ]

9

true

Homologous_superfamily

S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain superfamily

SAM-dep_MeTrfase_MraW_recog

4

IPR023398

23,398

Translation Initiation factor eIF- 4e-like

TIF_eIF4e-like

Homologous_superfamily

20,699

false

This entry includes a group of eIF4E-like protein. These proteins consist of a curved eight-stranded antiparallel β-sheet, decorated with three helices on the convex face and three smaller helices inserted in connecting loops [ ]. Eukaryotic translation initiation factor 4E (eIF-4E) [ ] is a protein that binds to the c...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:3.30.760.10", "SSF55418" ]

[ "", "" ]

[ 20625, 20610 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1169408", "R-CEL-156827", "R-CEL-72649", "R-CEL-72662", "R-CEL-72702", "R-DDI-1169408", "R-DDI-156827", "R-DDI-166208", "R-DDI-72662", "R-DDI-72702", "R-DME-110523", "R-DME-1169408", "R-DME-156827", "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-166208", "R-DME-72649...

[ "REACTOME:R-CEL-1169408", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-72649", "REACTOME:R-CEL-72662", "REACTOME:R-CEL-72702", "REACTOME:R-DDI-1169408", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-166208", "REACTOME:R-DDI-72662", "REACTOME:R-DDI-72702", "REACTOME:R-DME-110523", "REACTOME:R-DME-116940...

72

[ "1ap8", "1ej1", "1ej4", "1ejh", "1ipb", "1ipc", "1l8b", "1rf8", "1wkw", "1ztp", "2gpq", "2idr", "2idv", "2jgb", "2jgc", "2q4k", "2v8w", "2v8x", "2v8y", "2w97", "2wmc", "3am7", "3hxg", "3hxi", "3m93", "3m94", "3tf2", "3u7x", "4axg", "4aza", "4b6u", "4b6v"...

115

[ "PUB00000866", "PUB00001603", "PUB00036324" ]

[ "1733496", "1672854", "9302999" ]

[ "Cap recap: the involvement of eIF-4F in regulating gene expression.", "Combination of Trp and Glu residues for recognition of mRNA cap structure. Analysis of m7G base recognition site of human cap binding protein (IF-4E) by site-directed mutagenesis.", "Structure of translation factor eIF4E bound to m7GDP and ...

[ 1992, 1991, 1997 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 105, 95, 20168, 94, 237 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 17, 6, 26, 18, 27, 30, 5, 3, 28, 1, 2, 18 ]

12

true

Homologous_superfamily

Translation Initiation factor eIF- 4e-like

TIF_eIF4e-like

9

IPR023399

23,399

Baseplate-like, two-layer sandwich fold

Baseplate-like_2-layer_sand

Homologous_superfamily

2,563

false

This entry represents an α/β two layer sandwich found in baseplate proteins and related sequences.

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.1920.10" ]

[ "" ]

[ 2563 ]

1

[]

0

[ "1wru", "3cdd", "3d37", "9ki1" ]

4

[]

0

[]

0

null

[ "Bacteria", "Caldiarchaeum subterraneum", "Eukaryota", "Viruses", "metagenomes" ]

[ 2483, 1, 8, 58, 13 ]

5

[]

0

true

Homologous_superfamily

Baseplate-like, two-layer sandwich fold

Baseplate-like_2-layer_sand

5

IPR023400

23,400

DNA recombination and repair protein RecA, C-terminal, superfamily

RecA_C_sf

Homologous_superfamily

29,694

false

The recA gene product is a multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response [ ]. In homologous recombination, the protein functions as a DNA-dependent ATPase, promoting synapsis, heteroduplex formation and strand exchange between homologous DNAs [ ]. Rec...

[]

0

[ "SSF" ]

[ "SSF54752" ]

[ "" ]

[ 29694 ]

1

[]

0

[ "1aa3", "1g18", "1g19", "1mo3", "1mo4", "1mo5", "1mo6", "1n03", "1rea", "1u94", "1u98", "1u99", "1ubc", "1ube", "1ubf", "1ubg", "1xms", "1xmv", "1xp8", "2g88", "2odn", "2odw", "2oe2", "2oep", "2oes", "2ofo", "2reb", "2rec", "2zr0", "2zr7", "2zr9", "2zra"...

85

[ "PUB00002285", "PUB00003439", "PUB00003747", "PUB00004797", "PUB00004946", "PUB00037852", "PUB00043276" ]

[ "7592482", "8587109", "1896024", "1518831", "9187054", "15364575", "12045091" ]

[ "Bacterial classifications derived from recA protein sequence comparisons.", "The RecA protein as a model molecule for molecular systematic studies of bacteria: comparison of trees of RecAs and 16S rRNAs from the same species.", "Characterization of recA genes and recA mutants of Rhizobium meliloti and Rhizobiu...

[ 1995, 1995, 1991, 1992, 1997, 2004, 2002 ]

7

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 27100, 1, 1877, 129, 587 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 12, 1, 10, 22 ]

4

true

Homologous_superfamily

DNA recombination and repair protein RecA, C-terminal, superfamily

RecA_C_sf

5

IPR023401

23,401

Ornithine cyclodeaminase, N-terminal

ODC_N

Homologous_superfamily

26,318

false

This entry represents the N-terminal domain of the ornithine cyclodeanimase family. This is an α/β two layer sandwich domain. Members of this family includes ornithine cyclodeanimase [ ], alanine dehydrogenase from Archaeoglobus [ ] and human cytosolic 3,5,39-triiodo-L-thyronine-binding protein, also called mu-crystall...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.1780.10" ]

[ "" ]

[ 26318 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-71064", "R-DDI-71064", "R-HSA-71064", "R-MMU-71064", "R-RNO-71064", "R-SCE-71064", "R-SPO-71064" ]

[ "REACTOME:R-BTA-71064", "REACTOME:R-DDI-71064", "REACTOME:R-HSA-71064", "REACTOME:R-MMU-71064", "REACTOME:R-RNO-71064", "REACTOME:R-SCE-71064", "REACTOME:R-SPO-71064" ]

7

[ "1omo", "1u7h", "1vll", "1x7d", "2i99", "3hdj", "4bv8", "4bv9", "4bva", "4m54", "4mp3", "4mp6", "4mp8", "4mpd", "5gzi", "5gzj", "5gzl", "5gzm", "5yu0", "5yu1", "5yu3", "5yu4", "6rqa", "6t3e", "7rbp", "8h8p", "8j1c", "8j1g" ]

28

[ "PUB00029492", "PUB00031693", "PUB00047686" ]

[ "15313611", "15518536", "17242435" ]

[ "Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin.", "Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family.", "Crystal structure of human micro-crystallin complexed...

[ 2004, 2004, 2007 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1328, 20608, 4059, 2, 321 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 5, 3, 1, 5, 2, 1, 2, 4, 1, 1, 5 ]

11

true

Homologous_superfamily

Ornithine cyclodeaminase, N-terminal

ODC_N

3

IPR023403

23,403

Uncharacterised protein MG237, N-terminal

Uncharacterised_MG237_N

Homologous_superfamily

7

false

This superfamily represents the N-terminal domain of hypothetical protein mg237 and homologues. It consists of four α helices [ ].

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.1480.10" ]

[ "" ]

[ 7 ]

1

[]

0

[ "1td6" ]

1

[ "PUB00037695" ]

[ "15562512" ]

[ "Crystal structure of the conserved hypothetical protein MPN330 (GI: 1674200) from Mycoplasma pneumoniae." ]

[ 2005 ]

1

[]

0

null

[ "Mycoplasmoides" ]

[ 7 ]

1

[]

0

true

Homologous_superfamily

Uncharacterised protein MG237, N-terminal

Uncharacterised_MG237_N

9

IPR023404

23,404

Radical SAM, alpha/beta horseshoe

rSAM_horseshoe

Homologous_superfamily

115,606

false

Radical SAM domains catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation. Evidence exists that these proteins generate a radical species by reductive cleavage of S:-adenosylmethionine (SAM) through an unusual Fe-S...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.80.30.20" ]

[ "" ]

[ 115606 ]

1

[ "EC", "REACTOME" ]

[ "2.8.4", "R-HSA-6782315" ]

[ "EC:2.8.4", "REACTOME:R-HSA-6782315" ]

2

[ "2qgq", "4jc0", "5ul2", "5ul3", "5ul4", "6fd2", "6wte", "6wtf", "7kdx", "7kdy", "7mjv", "7mjw", "7mjx", "7mjy", "7mjz", "9ccb" ]

16

[ "PUB00010539", "PUB00015124", "PUB00054243" ]

[ "11222759", "15317939", "20007320" ]

[ "Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods.", "Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybd...

[ 2001, 2004, 2010 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3252, 102318, 6859, 26, 3151 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 12, 2, 4, 2, 4, 7, 2, 6, 11, 11 ]

10

true

Homologous_superfamily

Radical SAM, alpha/beta horseshoe

rSAM_horseshoe

8

IPR023405

23,405

DNA topoisomerase, type IA, core domain

Topo_IA_core_domain

Homologous_superfamily

62,065

false

DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi...

[]

0

[ "SSF" ]

[ "SSF56712" ]

[ "" ]

[ 62065 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "5.6.2.1", "R-CEL-5693607", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693554", "R-HSA-5693568", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-912446", "R-HSA-9701192", "R-HSA-9704331", "R-HSA-9704646", "R-HSA-9709570", "R-HSA-9709603", "R...

[ "EC:5.6.2.1", "REACTOME:R-CEL-5693607", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693554", "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-5693579", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473", "REACTOME:R-HSA-912446...

26

[ "1cy0", "1cy1", "1cy2", "1cy4", "1cy6", "1cy7", "1cy8", "1cy9", "1cyy", "1d6m", "1ecl", "1gku", "1gl9", "1i7d", "1mw8", "1mw9", "2gai", "2gaj", "2o19", "2o54", "2o59", "2o5c", "2o5e", "3pwt", "3px7", "4cgy", "4cht", "4ddt", "4ddu", "4ddv", "4ddw", "4ddx"...

65

[ "PUB00005230", "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020798", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705" ]

[ "9488644", "7770916", "11395412", "12596227", "12042765", "11239459", "21087076", "20644584", "17722649", "17293019" ]

[ "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.",...

[ 1998, 1995, 2001, 2003, 2002, 2001, 2010, 2010, 2007, 2007 ]

10

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 1309, 48827, 10543, 61, 10, 1315 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 19, 4, 3, 6, 2, 24, 19, 1, 12, 3, 1, 1, 75 ]

13

true

Homologous_superfamily

DNA topoisomerase, type IA, core domain

Topo_IA_core_domain

1

IPR023406

23,406

DNA topoisomerase, type IA, active site

Topo_IA_AS

Active_site

48,054

false

This entry represents a number of conserved residues in the region around the active site tyrosine of type IA topoisomerases. DNA topoisomerase I ( ) is one of the two types of enzyme that catalyze the interconversion of topological DNA isomers [ , , ]. Type I topoisomerases act by catalyzing the transient breakage of ...

[ "GO:0003917" ]

[ "DNA topoisomerase type I (single strand cut, ATP-independent) activity" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS00396" ]

[ "TOPO_IA_1" ]

[ 48054 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "5.6.2.1", "R-CEL-5693607", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693554", "R-HSA-5693568", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-912446", "R-HSA-9701192", "R-HSA-9704331", "R-HSA-9704646", "R-HSA-9709570", "R-HSA-9709603", "R...

[ "EC:5.6.2.1", "REACTOME:R-CEL-5693607", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693554", "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-5693579", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473", "REACTOME:R-HSA-912446...

26

[ "1cy0", "1cy1", "1cy2", "1cy4", "1cy6", "1cy7", "1cy8", "1cy9", "1cyy", "1d6m", "1ecl", "1mw8", "1mw9", "2gai", "2gaj", "2o19", "2o54", "2o59", "2o5c", "2o5e", "3pwt", "3px7", "4cgy", "4cht", "4rul", "5d5h", "5gvc", "5gve", "5uj1", "5ujy", "6cq2", "6cqi"...

49

[ "PUB00001050", "PUB00001088", "PUB00005230", "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705" ]

[ "2560656", "7773745", "9488644", "7770916", "11395412", "12596227", "12042765", "21087076", "20644584", "17722649", "17293019" ]

[ "DNA topoisomerases.", "DNA topoisomerases.", "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles...

[ 1989, 1995, 1998, 1995, 2001, 2003, 2002, 2010, 2010, 2007, 2007 ]

11

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 750, 39031, 7513, 54, 5, 701 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (s...

[ 18, 3, 3, 3, 2, 6, 12, 8, 3, 1, 1, 51 ]

12

true

Active_site

DNA topoisomerase, type IA, active site

Topo_IA_AS

7

IPR023407

23,407

Small ribosomal subunit protein eS27, zinc-binding domain superfamily

Ribosomal_eS27_Zn-bd_dom_sf

Homologous_superfamily

9,148

false

This superfamily represents a domain found in the zinc-binding ribosomal protein eS27 (previously known as S27). It consists of a β-sandwich of two three-stranded sheets. This a novel fold due to the uniqueness of the strands arrangement [ ].

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.20.25.100" ]

[ "" ]

[ 9148 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-141444", "R-BTA-156827", "R-BTA-1799339", "R-BTA-2467813", "R-BTA-2500257", "R-BTA-5663220", "R-BTA-6791226", "R-BTA-68877", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-9648025", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-179...

[ "REACTOME:R-BTA-141444", "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA-2500257", "REACTOME:R-BTA-5663220", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-68877", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72...

107

[ "1qxf", "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q"...

622

[ "PUB00030432" ]

[ "15096641" ]

[ "The NMR solution structure of the 30S ribosomal protein S27e encoded in gene RS27_ARCFU of Archaeoglobus fulgidis reveals a novel protein fold." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 865, 6, 8253, 24 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 1, 4, 1, 6, 8, 1, 7, 22, 2, 1, 8 ]

12

true

Homologous_superfamily

Small ribosomal subunit protein eS27, zinc-binding domain superfamily

Ribosomal_eS27_Zn-bd_dom_sf

7

IPR023408

23,408

Mechanosensitive ion channel MscS, beta-domain superfamily

MscS_beta-dom_sf

Homologous_superfamily

94,297

false

Mechanosensitive (MS) channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation. They are present in the membranes of organisms from the three domains of life: bacteria, archaea, and eukarya [ ]. There are two families of MS channels: large...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.30.30.60" ]

[ "" ]

[ 94297 ]

1

[]

0

[ "1vie", "1vif", "2gqv", "2oau", "2p4t", "2rh2", "2rk1", "2rk2", "2vv5", "3sfm", "3t9n", "3udc", "4age", "4agf", "4hw9", "4hwa", "5aji", "5y4o", "6lyp", "6nxz", "6ny0", "6pwn", "6pwo", "6pwp", "6rld", "6urt", "6uzh", "6vxm", "6vxn", "6vxp", "6vyk", "6vyl"...

74

[ "PUB00013956", "PUB00013957", "PUB00089654", "PUB00097362", "PUB00101036" ]

[ "12446901", "12626684", "22910366", "25041276", "34376558" ]

[ "Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel.", "Two families of mechanosensitive channel proteins.", "Organellar mechanosensitive channels in fission yeast regulate the hypo-osmotic shock response.", "Mechanosensitive channels Msy1 and Msy2 are required for ma...

[ 2002, 2003, 2012, 2014, 2021 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3679, 80407, 9186, 9, 1016 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 44, 6, 2, 12, 2, 24 ]

6

true

Homologous_superfamily

Mechanosensitive ion channel MscS, beta-domain superfamily

MscS_beta-dom_sf

2

IPR023409

23,409

14-3-3 protein, conserved site

14-3-3_CS

Conserved_site

19,656

false

The 14-3-3 proteins are a family of closely related acidic homodimeric proteins of about 30kDa which were first identified as being very abundant in mammalian brain tissues and located preferentially in neurons [ , , ]. The 14-3-3 proteins seem to have multiple biological activities and play a key role in signal transd...

[]

0

[ "PROSITE", "PROSITE" ]

[ "PS00796", "PS00797" ]

[ "1433_1", "1433_2" ]

[ 18383, 16009 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-111447", "R-BTA-2028269", "R-BTA-205025", "R-BTA-2565942", "R-BTA-3371453", "R-BTA-3371511", "R-BTA-3769402", "R-BTA-380259", "R-BTA-380270", "R-BTA-380284", "R-BTA-380320", "R-BTA-392517", "R-BTA-430116", "R-BTA-450604", "R-BTA-512988", "R-BTA-5620912", "R-BTA-5625740", "R-...

[ "REACTOME:R-BTA-111447", "REACTOME:R-BTA-2028269", "REACTOME:R-BTA-205025", "REACTOME:R-BTA-2565942", "REACTOME:R-BTA-3371453", "REACTOME:R-BTA-3371511", "REACTOME:R-BTA-3769402", "REACTOME:R-BTA-380259", "REACTOME:R-BTA-380270", "REACTOME:R-BTA-380284", "REACTOME:R-BTA-380320", "REACTOME:R-BT...

242

[ "1a37", "1a38", "1a4o", "1ib1", "1o9c", "1o9d", "1o9e", "1o9f", "1qja", "1qjb", "1ywt", "1yz5", "2b05", "2bq0", "2br9", "2btp", "2c1j", "2c1n", "2c23", "2c63", "2c74", "2npm", "2o02", "2o98", "2v7d", "2wh0", "3axy", "3cu8", "3e6y", "3iqj", "3iqu", "3iqv"...

677

[ "PUB00004213", "PUB00005192", "PUB00005447" ]

[ "7603573", "7939645", "7709434" ]

[ "Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways.", "14-3-3: modulators of signaling proteins?", "14-3-3 proteins on the MAP." ]

[ 1995, 1994, 1995 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 19654 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 60, 5, 16, 6, 46, 21, 1, 13, 32, 2, 2, 92 ]

12

true

Conserved_site

14-3-3 protein, conserved site

14-3-3_CS

5

IPR023410

23,410

14-3-3 domain

14-3-3_domain

Domain

24,437

false

This entry represents the structural domain found in 14-3-3 proteins. The 14-3-3 proteins are a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells [ , ]. These are structurally similar phospho-binding proteins that regulate multiple signaling ...

[]

0

[ "PFAM", "SMART" ]

[ "PF00244", "SM00101" ]

[ "14-3-3", "14_3_3" ]

[ 24432, 22999 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-111447", "R-BTA-2028269", "R-BTA-205025", "R-BTA-2565942", "R-BTA-3371453", "R-BTA-3371511", "R-BTA-3769402", "R-BTA-380259", "R-BTA-380270", "R-BTA-380284", "R-BTA-380320", "R-BTA-392517", "R-BTA-430116", "R-BTA-450604", "R-BTA-512988", "R-BTA-5620912", "R-BTA-5625740", "R-...

[ "REACTOME:R-BTA-111447", "REACTOME:R-BTA-2028269", "REACTOME:R-BTA-205025", "REACTOME:R-BTA-2565942", "REACTOME:R-BTA-3371453", "REACTOME:R-BTA-3371511", "REACTOME:R-BTA-3769402", "REACTOME:R-BTA-380259", "REACTOME:R-BTA-380270", "REACTOME:R-BTA-380284", "REACTOME:R-BTA-380320", "REACTOME:R-BT...

242

[ "1a37", "1a38", "1a4o", "1ib1", "1o9c", "1o9d", "1o9e", "1o9f", "1qja", "1qjb", "1ywt", "1yz5", "2b05", "2bq0", "2br9", "2btp", "2c1j", "2c1n", "2c23", "2c63", "2c74", "2npm", "2o02", "2o8p", "2o98", "2v7d", "2wh0", "3axy", "3cu8", "3e6y", "3efz", "3iqj"...

700

[ "PUB00003264", "PUB00007085", "PUB00097184" ]

[ "1671102", "11911880", "29915393" ]

[ "Distinct forms of the protein kinase-dependent activator of tyrosine and tryptophan hydroxylases.", "How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis.", "The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent ...

[ 1991, 2002, 2018 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 24432 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 70, 6, 16, 7, 48, 23, 3, 19, 33, 2, 2, 123 ]

12

true

Domain

14-3-3 domain

14-3-3_domain

8

IPR023411

23,411

Ribonuclease A, active site

RNaseA_AS

Active_site

2,855

false

Pancreatic ribonucleases (RNaseA) are pyrimidine-specific endonucleases found in high quantity in the pancreas of certain mammals and of some reptiles [ ]. Specifically, the enzymes are involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cycli...

[]

0

[ "PROSITE" ]

[ "PS00127" ]

[ "RNASE_PANCREATIC" ]

[ 2855 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6803157", "R-DRE-418990", "R-DRE-6798695", "R-DRE-6803157", "R-GGA-418990", "R-GGA-6798695", "R-GGA-6803157", "R-HSA-418990", "R-HSA-6798695", "R-HSA-6803157", "R-HSA-9613829", "R-HSA-9615710", "R-HSA-9708296", "R-HSA-9925561", "R-MMU-418990", "R-MMU-6798695", "R-MMU-6803157",...

[ "REACTOME:R-BTA-6803157", "REACTOME:R-DRE-418990", "REACTOME:R-DRE-6798695", "REACTOME:R-DRE-6803157", "REACTOME:R-GGA-418990", "REACTOME:R-GGA-6798695", "REACTOME:R-GGA-6803157", "REACTOME:R-HSA-418990", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-6803157", "REACTOME:R-HSA-9613829", "REACTOME:R...

19

[ "11ba", "11bg", "1a2w", "1a4y", "1a5q", "1afk", "1afl", "1afu", "1agi", "1ang", "1aqp", "1awz", "1b1i", "1b1j", "1b6v", "1bc4", "1bel", "1bsr", "1bzq", "1c0b", "1c0c", "1c9v", "1c9x", "1cjq", "1cjr", "1d5d", "1d5e", "1d5h", "1dfj", "1dy5", "1dyt", "1dza"...

515

[ "PUB00000315", "PUB00001546", "PUB00003106", "PUB00004682", "PUB00004932", "PUB00005063" ]

[ "2611266", "3940901", "2473157", "2734298", "3074337", "2710786" ]

[ "Primary structure of a ribonuclease from porcine liver, a new member of the ribonuclease superfamily.", "Comparison of the structure of turtle pancreatic ribonuclease with those of mammalian ribonucleases.", "Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclea...

[ 1989, 1986, 1989, 1989, 1988, 1989 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "Myoviridae sp. ctwSu1" ]

[ 21, 2833, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 1, 22, 46, 30 ]

5

true

Active_site

Ribonuclease A, active site

RNaseA_AS

7

IPR023412

23,412

Ribonuclease A-domain

RNaseA_domain

Domain

4,491

false

Pancreatic ribonucleases (RNaseA) are pyrimidine-specific endonucleases found in high quantity in the pancreas of certain mammals and of some reptiles [ ]. Specifically, the enzymes are involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cycli...

[]

0

[ "PFAM", "SMART" ]

[ "PF00074", "SM00092" ]

[ "RnaseA", "RNAse_Pc" ]

[ 4391, 4223 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6803157", "R-DRE-418990", "R-DRE-6798695", "R-DRE-6803157", "R-GGA-418990", "R-GGA-6798695", "R-GGA-6803157", "R-HSA-418990", "R-HSA-6798695", "R-HSA-6803157", "R-HSA-9613829", "R-HSA-9615710", "R-HSA-9708296", "R-HSA-9925561", "R-MMU-418990", "R-MMU-6798695", "R-MMU-6803157",...

[ "REACTOME:R-BTA-6803157", "REACTOME:R-DRE-418990", "REACTOME:R-DRE-6798695", "REACTOME:R-DRE-6803157", "REACTOME:R-GGA-418990", "REACTOME:R-GGA-6798695", "REACTOME:R-GGA-6803157", "REACTOME:R-HSA-418990", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-6803157", "REACTOME:R-HSA-9613829", "REACTOME:R...

19

[ "11ba", "11bg", "1a2w", "1a4y", "1a5p", "1a5q", "1afk", "1afl", "1afu", "1agi", "1ang", "1aqp", "1awz", "1b1e", "1b1i", "1b1j", "1b6v", "1bc4", "1bel", "1bsr", "1bzq", "1c0b", "1c0c", "1c8w", "1c9v", "1c9x", "1cjq", "1cjr", "1d5d", "1d5e", "1d5h", "1dfj"...

525

[ "PUB00000315", "PUB00001546", "PUB00003106", "PUB00004682" ]

[ "2611266", "3940901", "2473157", "2734298" ]

[ "Primary structure of a ribonuclease from porcine liver, a new member of the ribonuclease superfamily.", "Comparison of the structure of turtle pancreatic ribonuclease with those of mammalian ribonucleases.", "Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclea...

[ 1989, 1986, 1989, 1989 ]

4

[]

0

null

[ "Bilateria" ]

[ 4491 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 1, 43, 59, 50 ]

5

true

Domain

Ribonuclease A-domain

RNaseA_domain

1

IPR023415

23,415

Low-density lipoprotein (LDL) receptor class A, conserved site

LDLR_class-A_CS

Conserved_site

74,308

false

Low-density lipoprotein (LDL) receptors are the major cholesterol-carrying lipoproteins of plasma. Seven successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein [ ]. Similar domains have been found (see references in [ ]) in other extracellular and mem...

[]

0

[ "PROSITE" ]

[ "PS01209" ]

[ "LDLRA_1" ]

[ 74308 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-166665", "R-BTA-8856825", "R-BTA-8856828", "R-BTA-8964026", "R-BTA-8964038", "R-BTA-9758890", "R-BTA-977606", "R-CFA-444821", "R-DME-9758890", "R-DRE-9842663", "R-GGA-8866376", "R-GGA-8866427", "R-HSA-1474228", "R-HSA-166665", "R-HSA-196791", "R-HSA-1971475", "R-HSA-201681", ...

[ "REACTOME:R-BTA-166665", "REACTOME:R-BTA-8856825", "REACTOME:R-BTA-8856828", "REACTOME:R-BTA-8964026", "REACTOME:R-BTA-8964038", "REACTOME:R-BTA-9758890", "REACTOME:R-BTA-977606", "REACTOME:R-CFA-444821", "REACTOME:R-DME-9758890", "REACTOME:R-DRE-9842663", "REACTOME:R-GGA-8866376", "REACTOME:R...

100

[ "1ajj", "1cr8", "1d2j", "1d2l", "1f5y", "1f8z", "1j8e", "1ldl", "1ldr", "1n7d", "1v9u", "1xfe", "2fcw", "2fyj", "2fyl", "2gtl", "2i1p", "2jm4", "2knx", "2kny", "2kri", "2lgp", "2m0p", "2m7p", "2m96", "2xrc", "3a7q", "3dpr", "3m0c", "3ojy", "3p5c", "3t5o"...

160

[ "PUB00000086", "PUB00000411", "PUB00000798", "PUB00004868", "PUB00005112" ]

[ "7979249", "7548065", "6091915", "7603991", "3283935" ]

[ "Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).", "Disulfide bridges of a cysteine-rich repeat of the LDL receptor ligand-binding domain.", "The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its m...

[ 1994, 1995, 1984, 1995, 1988 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 7, 74297, 2, 2 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 30, 226, 120, 193, 131, 149 ]

6

true

Conserved_site

Low-density lipoprotein (LDL) receptor class A, conserved site

LDLR_class-A_CS

7

IPR023416

23,416

Transthyretin/hydroxyisourate hydrolase domain

Transthyretin/HIU_hydrolase_d

Domain

16,503

false

This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourat...

[]

0

[ "PFAM", "PANTHER", "SMART" ]

[ "PF00576", "PTHR10395", "SM00095" ]

[ "Transthyretin", "", "TR_THY" ]

[ 16492, 15177, 6212 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-2453902", "R-BTA-6798695", "R-BTA-975634", "R-CEL-3000171", "R-CEL-6798695", "R-CEL-975634", "R-HSA-2453902", "R-HSA-3000171", "R-HSA-6798695", "R-HSA-975634", "R-HSA-977225", "R-HSA-9918449", "R-MMU-2453902", "R-MMU-6798695", "R-MMU-975634", "R-RNO-2453902", "R-RNO-6798695", ...

[ "REACTOME:R-BTA-2453902", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-975634", "REACTOME:R-CEL-3000171", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-975634", "REACTOME:R-HSA-2453902", "REACTOME:R-HSA-3000171", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-975634", "REACTOME:R-HSA-977225", "REACTOME:R-...

25

[ "1bm7", "1bmz", "1bz8", "1bzd", "1bze", "1dvq", "1dvs", "1dvt", "1dvu", "1dvx", "1dvy", "1dvz", "1e3f", "1e4h", "1e5a", "1eta", "1etb", "1f41", "1f86", "1fh2", "1fhn", "1g1o", "1gke", "1gko", "1ict", "1ie4", "1iii", "1iik", "1ijn", "1kgi", "1kgj", "1oo2"...

488

[ "PUB00001401", "PUB00001752", "PUB00002809", "PUB00034597", "PUB00041243", "PUB00042841", "PUB00071851", "PUB00101389" ]

[ "1833190", "4054629", "8428915", "16098976", "16952372", "16462750", "24422526", "33001386" ]

[ "Isolation, characterization, cDNA cloning and gene expression of an avian transthyretin. Implications for the evolution of structure and function of transthyretin in vertebrates.", "Structure of the chromosomal gene for human serum prealbumin.", "The x-ray crystal structure refinements of normal human transthy...

[ 1991, 1985, 1993, 2005, 2006, 2006, 2014, 2020 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 10987, 5393, 42, 1, 80 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 6, 2, 4, 1, 1, 6, 7, 1, 5, 11, 1, 8 ]

12

true

Domain

Transthyretin/hydroxyisourate hydrolase domain

Transthyretin/HIU_hydrolase_d

3

IPR023418

23,418

Transthyretin, thyroxine binding site

Thyroxine_BS

Binding_site

11,964

false

Transthyretin (prealbumin) is a thyroid hormone-binding protein that seems to transport thyroxine (T4) from the bloodstream to the brain. It is a protein of about 130 amino acids that assembles as a homotetramer and forms an internal channel that binds thyroxine. In humans, transthyretin is mainly synthesised in the br...

[]

0

[ "PROSITE" ]

[ "PS00768" ]

[ "TRANSTHYRETIN_1" ]

[ 11964 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-2453902", "R-BTA-6798695", "R-BTA-975634", "R-CEL-3000171", "R-CEL-6798695", "R-CEL-975634", "R-HSA-2453902", "R-HSA-3000171", "R-HSA-6798695", "R-HSA-975634", "R-HSA-977225", "R-HSA-9918449", "R-MMU-2453902", "R-MMU-6798695", "R-MMU-975634", "R-RNO-2453902", "R-RNO-6798695", ...

[ "REACTOME:R-BTA-2453902", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-975634", "REACTOME:R-CEL-3000171", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-975634", "REACTOME:R-HSA-2453902", "REACTOME:R-HSA-3000171", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-975634", "REACTOME:R-HSA-977225", "REACTOME:R-...

25

[ "1bm7", "1bmz", "1bz8", "1bzd", "1bze", "1dvq", "1dvs", "1dvt", "1dvu", "1dvx", "1dvy", "1dvz", "1e3f", "1e4h", "1e5a", "1etb", "1f41", "1f86", "1fhn", "1g1o", "1gke", "1gko", "1ict", "1ie4", "1iii", "1iik", "1ijn", "1kgi", "1kgj", "1qab", "1qwh", "1rlb"...

395

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8464, 3444, 56 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe...

[ 6, 2, 2, 1, 7, 3, 1, 5, 4, 1, 8 ]

11

true

Binding_site

Transthyretin, thyroxine binding site

Thyroxine_BS

2

IPR023419

23,419

Transthyretin, conserved site

Transthyretin_CS

Conserved_site

8,045

false

Transthyretin (prealbumin) is a thyroid hormone-binding protein that seems to transport thyroxine (T4) from the bloodstream to the brain. It is a protein of about 130 amino acids that assembles as a homotetramer and forms an internal channel that binds thyroxine. In humans, transthyretin is mainly synthesized in the br...

[]

0

[ "PROSITE" ]

[ "PS00769" ]

[ "TRANSTHYRETIN_2" ]

[ 8045 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2453902", "R-BTA-6798695", "R-BTA-975634", "R-CEL-3000171", "R-CEL-6798695", "R-CEL-975634", "R-HSA-2453902", "R-HSA-3000171", "R-HSA-6798695", "R-HSA-975634", "R-HSA-977225", "R-HSA-9918449", "R-MMU-2453902", "R-MMU-6798695", "R-MMU-975634", "R-RNO-2453902", "R-RNO-6798695", ...

[ "REACTOME:R-BTA-2453902", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-975634", "REACTOME:R-CEL-3000171", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-975634", "REACTOME:R-HSA-2453902", "REACTOME:R-HSA-3000171", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-975634", "REACTOME:R-HSA-977225", "REACTOME:R-...

22

[ "1bm7", "1bmz", "1bz8", "1bzd", "1bze", "1dvq", "1dvs", "1dvt", "1dvu", "1dvx", "1dvy", "1dvz", "1e3f", "1e4h", "1e5a", "1eta", "1etb", "1f41", "1f86", "1fh2", "1fhn", "1g1o", "1gke", "1gko", "1ict", "1ie4", "1kgi", "1kgj", "1qab", "1qwh", "1rlb", "1tfp"...

456

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 5532, 2422, 42, 49 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6, 2, 1, 5, 6, 1, 9, 1 ]

8

true

Conserved_site

Transthyretin, conserved site

Transthyretin_CS

5

IPR023420

23,420

Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily

Kinase_SYK/ZAP-70_inter-SH2_sf

Homologous_superfamily

2,093

false

Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substra...

[ "GO:0004715" ]

[ "non-membrane spanning protein tyrosine kinase activity" ]

[ "molecular_function" ]

1

[ "CATHGENE3D" ]

[ "G3DSA:1.10.930.10" ]

[ "" ]

[ 2093 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.10.2", "R-GGA-114604", "R-GGA-2029481", "R-GGA-2029482", "R-GGA-2029485", "R-GGA-2424491", "R-GGA-354192", "R-GGA-912631", "R-GGA-9674555", "R-GGA-9705462", "R-GGA-983695", "R-HSA-114604", "R-HSA-202430", "R-HSA-202433", "R-HSA-2029481", "R-HSA-2029482", "R-HSA-2029485", "R-HS...

[ "EC:2.7.10.2", "REACTOME:R-GGA-114604", "REACTOME:R-GGA-2029481", "REACTOME:R-GGA-2029482", "REACTOME:R-GGA-2029485", "REACTOME:R-GGA-2424491", "REACTOME:R-GGA-354192", "REACTOME:R-GGA-912631", "REACTOME:R-GGA-9674555", "REACTOME:R-GGA-9705462", "REACTOME:R-GGA-983695", "REACTOME:R-HSA-114604"...

72

[ "1a81", "1m61", "2oq1", "2ozo", "4fl2", "4fl3", "4k2r", "4xz0", "4xz1", "7q5t", "7q5u", "7q5w", "7q63", "7sa7" ]

14

[ "PUB00005115", "PUB00015362", "PUB00015714", "PUB00020114", "PUB00034898", "PUB00034899", "PUB00042254", "PUB00052410", "PUB00052411", "PUB00052412", "PUB00052529", "PUB00052530", "PUB00052531" ]

[ "3291115", "12368087", "1423621", "12471243", "15078142", "15320712", "7659156", "19275641", "16700535", "15845350", "19592646", "19670961", "8124727" ]

[ "The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.", "Evolution of protein kinase signaling from yeast to man.", "ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.", "The protein kinase complement of the human genome.", "High-through...

[ 1988, 2002, 1992, 2002, 2004, 2004, 1995, 2009, 2006, 2005, 2009, 2009, 1994 ]

13

[]

0

null

[ "Vertebrata" ]

[ 2093 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 7, 6, 9 ]

4

true

Homologous_superfamily

Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily

Kinase_SYK/ZAP-70_inter-SH2_sf

4

IPR023421

23,421

Axin interactor, dorsalization-associated protein, N-terminal

AIDA_N

Domain

1,178

false

This entry represents the N-terminal domain of the axin interactor, dorsalization-associated protein family AIDA [ ]. AIDA acts as a ventralizing factor during embryogenesis. It inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-indepe...

[]

0

[ "PFAM" ]

[ "PF08910" ]

[ "Aida_N" ]

[ 1178 ]

1

[]

0

[ "1ug7" ]

1

[ "PUB00053882" ]

[ "17681137" ]

[ "A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1178 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 2, 5 ]

4

true

Domain

Axin interactor, dorsalization-associated protein, N-terminal

AIDA_N

9

IPR023424

23,424

Oxaloacetate decarboxylase, gamma chain

OadG

Family

2,962

false

Oxaloacetate decarboxylases (OAD) catalyse the formation of pyruvate and CO 2 from oxaloacetate which utilises the free energy derived from oxaloacetate decarboxylation for sodium transport across the cell membrane. They are formed of three subunits; the alpha, beta and gamma subunits [ , ]. This entry represents the g...

[]

0

[ "HAMAP" ]

[ "MF_00404" ]

[ "OadG" ]

[ 2962 ]

1

[ "EC" ]

[ "7.2.4.2" ]

[ "EC:7.2.4.2" ]

1

[ "6iva", "6iww" ]

2

[ "PUB00019952", "PUB00099625" ]

[ "2549031", "32459174" ]

[ "The sodium ion translocating oxaloacetate decarboxylase of Klebsiella pneumoniae. Sequence of the integral membrane-bound subunits beta and gamma.", "Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump." ]

[ 1989, 2020 ]

2

[ "IPR005899" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 2944, 18 ]

2

[]

0

true

Family

Oxaloacetate decarboxylase, gamma chain

OadG

2

IPR023425

23,425

Galactose-1-phosphate uridyl transferase, class II, conserved site

GalP_uridyl_Trfase_II_CS

Conserved_site

3,329

false

Galactose-1-phosphate uridyl transferase (GalT) catalyses the transfer of an uridyldiphosphate group on galactose (or glucose) 1-phosphate. During the reaction, the uridyl moiety links to a histidine residue. In the Escherichia coli enzyme, it has been shown [ ] that two histidine residues separated by a single proline...

[ "GO:0008108" ]

[ "UDP-glucose:hexose-1-phosphate uridylyltransferase activity" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS01163" ]

[ "GAL_P_UDP_TRANSF_II" ]

[ 3329 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.7.7.12", "PWY-6317", "PWY-6527" ]

[ "EC:2.7.7.12", "METACYC:PWY-6317", "METACYC:PWY-6527" ]

3

[]

0

[ "PUB00002146", "PUB00004352" ]

[ "2066342", "2845364" ]

[ "Galactose utilization in Lactobacillus helveticus: isolation and characterization of the galactokinase (galK) and galactose-1-phosphate uridyl transferase (galT) genes.", "Conservation of short patches of amino acid sequence amongst proteins with a common function but evolutionarily distinct origins: implication...

[ 1991, 1988 ]

2

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "unclassified sequences" ]

[ 3321, 1, 7 ]

3

[]

0

true

Conserved_site

Galactose-1-phosphate uridyl transferase, class II, conserved site

GalP_uridyl_Trfase_II_CS

8

IPR023426

23,426

Flap endonuclease 1

Flap_endonuc

Family

5,591

false

This entry represents an endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment [ ]. It has 5'-endo-/exonuclease and 5'-pseudo-Y-endonuclease activities and cleaves the junction between single and...

[ "GO:0016788" ]

[ "hydrolase activity, acting on ester bonds" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00614" ]

[ "Fen" ]

[ 5591 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-110362", "R-BTA-174437", "R-BTA-5651801", "R-BTA-5685939", "R-BTA-69166", "R-CEL-5651801", "R-CEL-5685939", "R-CEL-69166", "R-DDI-110362", "R-DDI-5651801", "R-DDI-69166", "R-DME-5651801", "R-DME-5685939", "R-DME-69166", "R-DRE-110362", "R-GGA-5685939", "R-HSA-110362", "R-HSA...

[ "REACTOME:R-BTA-110362", "REACTOME:R-BTA-174437", "REACTOME:R-BTA-5651801", "REACTOME:R-BTA-5685939", "REACTOME:R-BTA-69166", "REACTOME:R-CEL-5651801", "REACTOME:R-CEL-5685939", "REACTOME:R-CEL-69166", "REACTOME:R-DDI-110362", "REACTOME:R-DDI-5651801", "REACTOME:R-DDI-69166", "REACTOME:R-DME-5...

38

[ "1a76", "1a77", "1b43", "1mc8", "1rxv", "1rxw", "1ul1", "2izo", "3ory", "3q8k", "3q8l", "3q8m", "4wa8", "5fv7", "5k97", "5kse", "5um9", "5zod", "5zoe", "5zof", "5zog", "6tnz", "7qo1", "8yjh", "8yjl", "8yjq", "8yjr", "8yjs", "8yju", "8yjv", "8yjw", "8yjz"...

34

[ "PUB00054247" ]

[ "9852084" ]

[ "Characterization of FEN-1 from Xenopus laevis. cDNA cloning and role in DNA metabolism." ]

[ 1998 ]

1

[ "IPR006084" ]

[ "IPR019973" ]

1

0

[ "Archaea", "Bacteria", "Emiliania huxleyi virus 86 (isolate United Kingdom/English Channel/1999)", "Eukaryota", "ecological metagenomes" ]

[ 948, 3, 1, 4614, 25 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 3, 7, 1, 3, 1, 1, 1, 11 ]

12

true

Family

Flap endonuclease 1

Flap_endonuc

7

IPR023427

23,427

Acetyl-CoA decarbonylase/synthase complex, gamma subunit, archaea

AcylCoA_decarb/synth_gsu_arc

Family

209

false

This entry represents the ACDS gamma subunit in archaea. This group represents the gamma subunit of acetyl-CoA decarbonylase/synthase (ACDS), a complex catalysing the reversible cleavage of acetyl-CoA. Depending on the direction of the reaction this complex allows either growth on acetate as sole carbon and energy sour...

[ "GO:0008168", "GO:0006084" ]

[ "methyltransferase activity", "acetyl-CoA metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_01136" ]

[ "CdhE" ]

[ 209 ]

1

[ "EC" ]

[ "2.1.1.245" ]

[ "EC:2.1.1.245" ]

1

[]

0

[ "PUB00043434", "PUB00043435", "PUB00043436" ]

[ "14709073", "14664578", "18442256" ]

[ "Chemically distinct Ni sites in the A-cluster in subunit beta of the acetyl-CoA decarbonylase/synthase complex from Methanosarcina thermophila: Ni L-edge absorption and X-ray magnetic circular dichroism analyses.", "The A-cluster in subunit beta of the acetyl-CoA decarbonylase/synthase complex from Methanosarcin...

[ 2004, 2003, 2008 ]

3

[ "IPR016218" ]

[]

1

0

1

[ "Archaea", "candidate division TA06 bacterium", "ecological metagenomes" ]

[ 206, 1, 2 ]

3

[]

0

true

Family

Acetyl-CoA decarbonylase/synthase complex, gamma subunit, archaea

AcylCoA_decarb/synth_gsu_arc

6

IPR023428

23,428

Photosystem II PsbX, type 2 subfamily

PSII_PsbX_type_2_subfam

Family

21

false

The protein family of PsbX, also known as Photosystem II reaction center protein X, can be divided into two subfamilies; this one, which is found only in some Prochlorococcus, and a shorter one with a wider taxonomic distribution. This entry represents type 1 subfamily, whose members are currently uncharacterised. The ...

[]

0

[ "HAMAP" ]

[ "MF_01388" ]

[ "PSII_PsbX_2" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00014965", "PUB00015357", "PUB00015358", "PUB00015359", "PUB00015378", "PUB00097583", "PUB00152828" ]

[ "11230572", "12518057", "15100025", "14871485", "11202442", "30076221", "33846594" ]

[ "Targeted disruption of psbX and biochemical characterization of photosystem II complex in the thermophilic cyanobacterium Synechococcus elongatus.", "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The evolutionary development of the protein complem...

[ 2001, 2003, 2004, 2004, 2000, 2018, 2021 ]

7

[ "IPR009518" ]

[]

1

0

1

[ "Prochlorococcus marinus" ]

[ 21 ]

1

[]

0

true

Family

Photosystem II PsbX, type 2 subfamily

PSII_PsbX_type_2_subfam

2

IPR023430

23,430

Peptidase HybD-like domain superfamily

Pept_HybD-like_dom_sf

Homologous_superfamily

16,899

false

This superfamily represents a structural domain described for HybD and related proteins such as the germination protease from Gram-positive bacteria. It consists of a twisted five-stranded β-sheet surrounded by four and three helices, respectively, on each side [ ].

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:3.40.50.1450", "SSF53163" ]

[ "", "" ]

[ 13738, 16859 ]

2

[ "EC" ]

[ "3.4.24.78" ]

[ "EC:3.4.24.78" ]

1

[ "1c8b", "1cfz", "2e85", "2i8l", "2kml", "3pu6", "5ija", "5ttx", "5zby", "7c4x" ]

10

[ "PUB00011023" ]

[ "10331925" ]

[ "Crystal structure of the hydrogenase maturating endopeptidase HYBD from Escherichia coli." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacillus phage G", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 822, 1, 15784, 7, 285 ]

5

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Homologous_superfamily

Peptidase HybD-like domain superfamily

Pept_HybD-like_dom_sf

3

IPR023431

23,431

Photosystem II PsbX, type 1 subfamily

PSII_PsbX_type_1_subfam

Family

755

false

The protein family of PsbX, also known as Photosystem II reaction center protein X, can be divided into two subfamilies; this one and a longer one found in most but not all Prochlorococcus. This entry represents type 1 subfamily, whose members are mainly found in cyanobacteria, red algae and diatoms, including members ...

[]

0

[ "HAMAP" ]

[ "MF_01386" ]

[ "PSII_PsbX_1" ]

[ 755 ]

1

[]

0

[ "1s5l", "3kzi", "3wu2", "4fby", "4il6", "4ixq", "4ixr", "4pbu", "4pj0", "4rvy", "4tnh", "4tni", "4tnj", "4tnk", "4ub6", "4ub8", "4v62", "4v82", "4yuu", "5b5e", "5b66", "5e79", "5e7c", "5gth", "5gti", "5kaf", "5kai", "5mx2", "5tis", "5v2c", "5ws5", "5ws6"...

129

[ "PUB00014965", "PUB00015357", "PUB00015358", "PUB00015359", "PUB00015378", "PUB00097583", "PUB00152828", "PUB00153318", "PUB00153319" ]

[ "11230572", "12518057", "15100025", "14871485", "11202442", "30076221", "33846594", "34216574", "34937700" ]

[ "Targeted disruption of psbX and biochemical characterization of photosystem II complex in the thermophilic cyanobacterium Synechococcus elongatus.", "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The evolutionary development of the protein complem...

[ 2001, 2003, 2004, 2004, 2000, 2018, 2021, 2021, 2022 ]

9

[ "IPR009518" ]

[]

1

0

1

[ "Cyanobacteriota", "Eukaryota" ]

[ 311, 444 ]

2

[]

0

true

Family

Photosystem II PsbX, type 1 subfamily

PSII_PsbX_type_1_subfam

3

IPR023432

23,432

Acetyl-CoA decarbonylase/synthase complex subunit beta, archaeal

CO_DH/Ac-CoA_synth_bsu_arc

Family

196

false

The carbon monoxide dehydrogenase alpha subunit ( ) catalyses the interconversion of CO and CO2 and the synthesis of acteyl-coA from the methylated corrinoid/iron sulphur protein, CO and CoA. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon (2...

[ "GO:0043885", "GO:0006084" ]

[ "anaerobic carbon-monoxide dehydrogenase activity", "acetyl-CoA metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_01138" ]

[ "CdhC" ]

[ 196 ]

1

[ "EC" ]

[ "2.3.1.169" ]

[ "EC:2.3.1.169" ]

1

[ "9c0s", "9c0t" ]

2

[]

0

[ "IPR004461" ]

[]

1

0

1

[ "Archaea", "ecological metagenomes" ]

[ 192, 4 ]

2

[]

0

true

Family

Acetyl-CoA decarbonylase/synthase complex subunit beta, archaeal

CO_DH/Ac-CoA_synth_bsu_arc

5

IPR023434

23,434

Argininosuccinate synthase, type 1 subfamily

Arginosuc_synth_type_1_subfam

Family

27,794

false

This entry represents argininosuccinate synthase, type 1 subfamily. Argininosuccinate synthase ( ) (AS) is a urea cycle enzyme that catalyses the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate [ , ]. In humans, a defect i...

[ "GO:0004055" ]

[ "argininosuccinate synthase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "CDD" ]

[ "MF_00005", "cd01999" ]

[ "Arg_succ_synth_type1", "ASS" ]

[ 20117, 27794 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.4.5", "PWY-4983", "PWY-4984", "PWY-5", "PWY-5154", "PWY-7400", "R-BTA-70635", "R-HSA-70635", "R-MMU-70635" ]

[ "EC:6.3.4.5", "METACYC:PWY-4983", "METACYC:PWY-4984", "METACYC:PWY-5", "METACYC:PWY-5154", "METACYC:PWY-7400", "REACTOME:R-BTA-70635", "REACTOME:R-HSA-70635", "REACTOME:R-MMU-70635" ]

9

[ "1j1z", "1j20", "1j21", "1k92", "1k97", "1kh1", "1kh2", "1kh3", "1kor", "1kp2", "1kp3", "1vl2", "2nz2", "4nzp", "4u7j", "4xfj", "5us8", "6e5y", "6xnq", "7k5z" ]

20

[ "PUB00001799", "PUB00002066" ]

[ "2123815", "3133361" ]

[ "Sequences of the genes encoding argininosuccinate synthetase in Escherichia coli and Saccharomyces cerevisiae: comparison with methanogenic archaebacteria and mammals.", "Conservation of structure in the human gene encoding argininosuccinate synthetase and the argG genes of the archaebacteria Methanosarcina bark...

[ 1990, 1988 ]

2

[ "IPR001518" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 814, 22234, 4290, 1, 455 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae...

[ 4, 1, 1, 1, 4, 3, 2, 3, 3, 1, 1, 10 ]

12

true

Family

Argininosuccinate synthase, type 1 subfamily

Arginosuc_synth_type_1_subfam

5

IPR023435

23,435

D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit KbaZ

TagBP_ald_KbaZ

Family

347

false

Escherichia coli and other enteric bacteria contain two closely related D-tagatose 1,6-bisphosphate (TagBP)-specific aldolases involved in catabolism of galactitol (genes gatY gatZ) and of N-acetyl-galactosamine and D-galactosamine (genes kbaY, kbaZ, also called agaY, agaZ). The catalytic subunits GatY/KbaY alone are s...

[]

0

[ "HAMAP" ]

[ "MF_01295" ]

[ "Tagatose_aldol_KbaZ" ]

[ 347 ]

1

[]

0

[]

0

[ "PUB00003595", "PUB00014682", "PUB00014683", "PUB00014684", "PUB00092978" ]

[ "8932697", "10931310", "11976750", "8955298", "30879203" ]

[ "Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli.", "Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.", "Two class II D-tagatose-bisphosphate aldola...

[ 1996, 2000, 2002, 1996, 2019 ]

5

[ "IPR012062" ]

[]

1

0

1

[ "Enterobacterales" ]

[ 347 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit KbaZ

TagBP_ald_KbaZ

2

IPR023436

23,436

D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit GatZ

TagBP_ald_GatZ

Family

914

false

Escherichia coli and other enteric bacteria contain two closely related D-tagatose 1,6-bisphosphate (TagBP)-specific aldolases involved in catabolism of galactitol (genes gatY gatZ) and of N-acetyl-galactosamine and D-galactosamine (genes kbaY, kbaZ, also called agaY, agaZ). The catalytic subunits GatY/KbaY alone are s...

[ "GO:0019402" ]

[ "galactitol metabolic process" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_01296", "NF011626" ]

[ "Tagatose_aldol_GatZ", "PRK15052.1" ]

[ 795, 913 ]

2

[]

0

[ "2fiq" ]

1

[ "PUB00003595", "PUB00014682", "PUB00014683", "PUB00014684", "PUB00092978" ]

[ "8932697", "10931310", "11976750", "8955298", "30879203" ]

[ "Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli.", "Pathways for the utilization of N-acetyl-galactosamine and galactosamine in Escherichia coli.", "Two class II D-tagatose-bisphosphate aldola...

[ 1996, 2000, 2002, 1996, 2019 ]

5

[ "IPR012062" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 914 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit GatZ

TagBP_ald_GatZ

7

IPR023437

23,437

Argininosuccinate synthase, type 2 subfamily

Arg_succ_synth_type2_subfam

Family

4,770

false

Argininosuccinate synthase ( ) (AS) is a urea cycle enzyme that catalyses the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate [ , ]. In humans, a defect in the AS gene causes citrullinemia, a genetic disease characterised ...

[ "GO:0004055" ]

[ "argininosuccinate synthase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_00581", "NF003779" ]

[ "Arg_succ_synth_type2", "PRK05370.1" ]

[ 4494, 4767 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "6.3.4.5", "PWY-4983", "PWY-4984", "PWY-5", "PWY-5154", "PWY-7400" ]

[ "EC:6.3.4.5", "METACYC:PWY-4983", "METACYC:PWY-4984", "METACYC:PWY-5", "METACYC:PWY-5154", "METACYC:PWY-7400" ]

6

[ "1k92", "1k97", "1kp2", "1kp3", "5us8", "6e5y" ]

6

[ "PUB00001799", "PUB00002066", "PUB00028813", "PUB00104182" ]

[ "2123815", "3133361", "11738042", "10666579" ]

[ "Sequences of the genes encoding argininosuccinate synthetase in Escherichia coli and Saccharomyces cerevisiae: comparison with methanogenic archaebacteria and mammals.", "Conservation of structure in the human gene encoding argininosuccinate synthetase and the argG genes of the archaebacteria Methanosarcina bark...

[ 1990, 1988, 2001, 1999 ]

4

[ "IPR001518" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4634, 2, 134 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Argininosuccinate synthase, type 2 subfamily

Arg_succ_synth_type2_subfam

8

IPR023444

23,444

L-rhamnonate dehydratase

L-Rhamnon_dehydrat

Family

2,938

false

L-rhamnonate dehydratase belongs to the mandelate racemase/muconate lactonizing enzyme family, specifically the RhamD subfamily. L-rhamnonate dehydratase ( ) catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR) L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate+ H(2)O. This reaction proceeds via a ...

[ "GO:0050032" ]

[ "L-rhamnonate dehydratase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM", "SFLD", "CDD" ]

[ "MF_01288", "NF011968", "SFLDF00006", "cd03327" ]

[ "Rhamnon_dehydrat", "PRK15440.1", "rhamnonate_dehydratase", "MR_like_2" ]

[ 1161, 2406, 2214, 2588 ]

4

[ "EC", "METACYC", "METACYC" ]

[ "4.2.1.90", "PWY-6713", "PWY-6714" ]

[ "EC:4.2.1.90", "METACYC:PWY-6713", "METACYC:PWY-6714" ]

3

[ "2gsh", "2i5q", "2oz3", "2p0i", "2p3z", "3box", "3cxo", "3d46", "3d47", "3ekg", "3fxg", "3sqs", "3ssz", "3stp" ]

14

[]

0

[ "IPR046945" ]

[ "IPR034619" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 23, 1727, 1170, 18 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 1 ]

2

true

Family

L-rhamnonate dehydratase

L-Rhamnon_dehydrat

8

IPR023445

23,445

Arginine exporter protein ArgO, enterobacteria

Arg_export_ArgO_enterobac

Family

1,270

false

The arginine exporter protein ArgO is involved in the export of arginine and is important to control the intracellular level of arginine and the correct balance between arginine and lysine [ ].

[ "GO:0061459", "GO:1903826" ]

[ "L-arginine transmembrane transporter activity", "L-arginine transmembrane transport" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01901", "NF006801" ]

[ "ArgO", "PRK09304.1" ]

[ 1240, 1269 ]

2

[]

0

[]

0

[ "PUB00042858" ]

[ "15150242" ]

[ "Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli." ]

[ 2004 ]

1

[ "IPR004777" ]

[]

1

0

1

[ "Bacteria", "human gut metagenome" ]

[ 1269, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Arginine exporter protein ArgO, enterobacteria

Arg_export_ArgO_enterobac

3

IPR023447

23,447

Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, ferredoxin-like superfamily

ForMFR_H4MPT_ForTrfase_fd-like

Homologous_superfamily

1,189

false

This superfamily represents two ferredoxin-like domains found in Ftr. Formylmethanofuran:tetrahyromethanopterin formyltransferase (Ftr) is involved in C1 metabolism in methanogenic archaea, sulphate-reducing archaea and methylotrophic bacteria. It catalyses the following reversible reaction: N-formylmethanofuran + 5,6,...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:3.30.70.520", "SSF55112" ]

[ "", "" ]

[ 1183, 1188 ]

2

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.1.101", "PWY-5209", "PWY-7784", "PWY-8305" ]

[ "EC:2.3.1.101", "METACYC:PWY-5209", "METACYC:PWY-7784", "METACYC:PWY-8305" ]

4

[ "1ftr", "1m5h", "1m5s", "2fhj", "2fhk", "6s6y" ]

6

[ "PUB00005787", "PUB00016939", "PUB00016940" ]

[ "9195883", "12192072", "12123819" ]

[ "Formylmethanofuran: tetrahydromethanopterin formyltransferase from Methanopyrus kandleri - new insights into salt-dependence and thermostability.", "Crystal structures and enzymatic properties of three formyltransferases from archaea: environmental adaptation and evolutionary relationship.", "Generation of for...

[ 1997, 2002, 2002 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Cladocopium goreaui", "unclassified sequences" ]

[ 356, 775, 2, 56 ]

4

[]

0

true

Homologous_superfamily

Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr, ferredoxin-like superfamily

ForMFR_H4MPT_ForTrfase_fd-like

2

IPR023449

23,449

L-carnitine/gamma-butyrobetaine antiporter CaiT

BCCT_transptr_CaiT

Family

575

false

CaiT is a membrane antiporter that catalyses the exchange of L-carnitine for gamma-butyrobetaine, which is the excreted end product of the carnitine pathway [ , ]. CaiT belongs to a family known as BCCT (for Betaine / Carnitine / Choline Transporters) [ ], which are specific for compounds containing a quaternary nitrog...

[ "GO:0044667", "GO:1900749", "GO:1900751", "GO:0016020" ]

[ "(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity", "(R)-carnitine transport", "4-(trimethylammonio)butanoate transport", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "HAMAP" ]

[ "MF_01049" ]

[ "CaiT" ]

[ 575 ]

1

[]

0

[ "2wsw", "2wsx", "3hfx", "4m8j" ]

4

[ "PUB00002302", "PUB00003866", "PUB00053911", "PUB00054251", "PUB00054253", "PUB00061640", "PUB00061643" ]

[ "8752321", "7815937", "9037756", "12163501", "12081978", "20923416", "20357772" ]

[ "Three transport systems for the osmoprotectant glycine betaine operate in Bacillus subtilis: characterization of OpuD.", "Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli.", "Bacterial carnitine metabolism.", "CaiT of Escherichia coli, a new transporter cata...

[ 1996, 1994, 1997, 2002, 2002, 2010, 2010 ]

7

[ "IPR000060" ]

[]

1

0

1

[ "Enterobacterales" ]

[ 575 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

L-carnitine/gamma-butyrobetaine antiporter CaiT

BCCT_transptr_CaiT

5

IPR023450

23,450

Crotonobetainyl-CoA reductase CaiA

CaiA

Family

579

false

Many enterobacteria are able to convert carnitine, via crotonobetaine, to gamma-butyrobetaine in the presence of carbon and nitrogen sources under anaerobic conditions [ ]. In Escherichia coli the enzymes involved in this pathway are encoded by the caiTABCDE operon [ ]. The adjacent but divergent fixABCD operon also ap...

[ "GO:0016627", "GO:0009437" ]

[ "oxidoreductase activity, acting on the CH-CH group of donors", "carnitine metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_01052" ]

[ "CaiA" ]

[ 579 ]

1

[ "EC" ]

[ "1.3.8.13" ]

[ "EC:1.3.8.13" ]

1

[]

0

[ "PUB00003866", "PUB00053911", "PUB00054252", "PUB00054253" ]

[ "7815937", "9037756", "15731894", "12081978" ]

[ "Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli.", "Bacterial carnitine metabolism.", "Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp.", "The fixA and fixB genes are necessary...

[ 1994, 1997, 2005, 2002 ]

4

[]

0

null

[ "Enterobacterales" ]

[ 579 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Crotonobetainyl-CoA reductase CaiA

CaiA

9

IPR023451

23,451

Thymidylate synthase/dCMP hydroxymethylase domain

Thymidate_synth/dCMP_Mease_dom

Domain

29,925

false

Thymidylate synthase ( ) [ , ] catalyzes the reductive methylation of dUMP to dTMP with concomitant conversion of 5,10-methylenetetrahydrofolate to dihydrofolate: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP This provides the sole de novo pathway for production of dTMP and is the only enzyme in folate m...

[]

0

[ "PFAM", "CDD" ]

[ "PF00303", "cd00351" ]

[ "Thymidylat_synt", "TS_Pyrimidine_HMase" ]

[ 29924, 27484 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.45", "PWY-3841", "PWY-7184", "PWY-7187", "PWY-7198", "PWY-7199", "PWY-7210", "R-DME-499943", "R-HSA-499943", "R-HSA-69205", "R-MMU-499943", "R-RNO-499943", "R-SCE-499943", "R-SPO-499943" ]

[ "EC:2.1.1.45", "METACYC:PWY-3841", "METACYC:PWY-7184", "METACYC:PWY-7187", "METACYC:PWY-7198", "METACYC:PWY-7199", "METACYC:PWY-7210", "REACTOME:R-DME-499943", "REACTOME:R-HSA-499943", "REACTOME:R-HSA-69205", "REACTOME:R-MMU-499943", "REACTOME:R-RNO-499943", "REACTOME:R-SCE-499943", "REACT...

14

[ "1aiq", "1ajm", "1an5", "1aob", "1axw", "1b02", "1b49", "1b5d", "1b5e", "1bdu", "1bid", "1bjg", "1bko", "1bkp", "1bo7", "1bo8", "1bp0", "1bp6", "1bpj", "1bq1", "1bq2", "1bsf", "1bsp", "1ci7", "1ddu", "1dna", "1ev5", "1ev8", "1evf", "1evg", "1f28", "1f4b"...

347

[ "PUB00000031", "PUB00000137", "PUB00002591", "PUB00005100", "PUB00023500", "PUB00030463", "PUB00036705", "PUB00037605", "PUB00081476", "PUB00081477", "PUB00081481" ]

[ "6996564", "2117882", "2243092", "3099389", "10064578", "14555647", "16615077", "16511011", "16162288", "16178783", "7574499" ]

[ "On the mechanism of action of folate- and biopterin-requiring enzymes.", "Cloning and characterization of the thymidylate synthase gene from Lactococcus lactis subsp. lactis.", "Structural and functional analysis of the human thymidylate synthase gene.", "Atomic structure of thymidylate synthase: target for ...

[ 1980, 1990, 1990, 1987, 1999, 2003, 2006, 2005, 2005, 2005, 1995 ]

11

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 536, 21027, 5944, 1901, 517 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 20, 2, 1, 2, 1, 4, 11, 1, 9, 3, 1, 1, 22 ]

13

true

Domain

Thymidylate synthase/dCMP hydroxymethylase domain

Thymidate_synth/dCMP_Mease_dom

1

IPR023453

23,453

Methionine repressor MetJ domain superfamily

Met_repressor_MetJ_dom_sf

Homologous_superfamily

1,997

false

Binding of a specific DNA fragment and S-adenosyl methionine (SAM) co-repressor molecules to the Escherichia coli methionine repressor (MetJ) leads to a significant reduction in dynamic flexibility of the ternary complex, with considerable entropy-enthalpy compensation, not necessarily involving any overall conformatio...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.140.10" ]

[ "" ]

[ 1997 ]

1

[]

0

[ "1cma", "1cmb", "1cmc", "1mj2", "1mjk", "1mjl", "1mjm", "1mjo", "1mjp", "1mjq" ]

10

[ "PUB00000028", "PUB00006686", "PUB00008039", "PUB00013999", "PUB00037197" ]

[ "8092669", "8026581", "1406951", "1943695", "10986458" ]

[ "The Met repressor-operator complex: DNA recognition by beta-strands.", "Calorimetric studies of the energetics of protein-DNA interactions in the E. coli methionine repressor (MetJ) system.", "Crystal structure of the met repressor-operator complex at 2.8 A resolution reveals DNA recognition by beta-strands.",...

[ 1994, 1994, 1992, 1991, 2000 ]

5

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 1989, 3, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Homologous_superfamily

Methionine repressor MetJ domain superfamily

Met_repressor_MetJ_dom_sf

2

IPR023454

23,454

Small ribosomal subunit protein uS2, archaea

Ribosomal_uS2_arc

Family

845

false

This entry represents the archaeal ribosomal protein uS2 family. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in acco...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP" ]

[ "MF_00291_A" ]

[ "Ribosomal_uS2_A" ]

[ 845 ]

1

[]

0

[ "1vi5", "1vi6", "4v4n", "4v6u", "5jb3", "5jbh", "6skf", "6skg", "6sw9", "6swc", "6swd", "6th6", "6tmf", "7zag", "7zah", "7zai", "7zhg", "8hkx", "8hky", "8hkz", "8hl1", "8hl2", "8hl3", "8hl4", "8hl5", "8wkp", "8wq2", "8wq4", "9e71", "9e7f", "9fhl", "9fny"...

45

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR005707" ]

[]

1

0

1

[ "Archaea", "Candidatus Nomurabacteria bacterium GW2011_GWA2_40_9", "Geodia barretti", "unclassified sequences" ]

[ 830, 1, 1, 13 ]

4

[]

0

true

Family

Small ribosomal subunit protein uS2, archaea

Ribosomal_uS2_arc

6

IPR023455

23,455

Dihydroorotate dehydrogenase electron transfer subunit

Dihydroorotate_DHASE_ETsu

Family

4,219

false

Dihydroorotate dehydrogenase ( ) (DHOdehase) catalyzes the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein. In bacteria (gene pyrD), DHOdease is located on the inner side of the cytosolic membrane. In some yeasts, such as i...

[]

0

[ "HAMAP" ]

[ "MF_01211" ]

[ "DHODB_Fe_S_bind" ]

[ 4219 ]

1

[]

0

[ "1ep1", "1ep2", "1ep3", "5ksw", "5ue9" ]

5

[ "PUB00004801", "PUB00033241" ]

[ "1409592", "8910599" ]

[ "Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts.", "The B form of dihydroorotate dehydrogenase from Lactococcus lactis consists of two different subunits, encoded by the pyrDb and pyrK genes, and contains FMN, FAD, and [FeS] redox centers." ]

[ 1992, 1996 ]

2

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 196, 3989, 34 ]

3

[]

0

true

Family

Dihydroorotate dehydrogenase electron transfer subunit

Dihydroorotate_DHASE_ETsu

8