LiteFold/InterPro · Datasets at Hugging Face

IPR023842

23,842

Bacillithiol biosynthesis deacetylase, BshB1

Bacillithiol_biosynth_BshB1

Family

3,505

false

Bacillithiol (BSH) is a low-molecular-weight thiol, an analog of glutathione and mycothiol, that is found largely in the Firmicutes. BSH biosynthesis requires the presence of the deacetylases BshB1 or BshB2 (also termed YpjG and YojG, respectively) [ ]. This entry represents BshB1, which catalyzes the second step of th...

[ "GO:0019213", "GO:0071793" ]

[ "deacetylase activity", "bacillithiol biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR04001" ]

[ "thiol_BshB1" ]

[ 3505 ]

1

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.5.1.-", "GenProp0927", "GenProp1505", "PWY-1822", "PWY-5497", "PWY-5784", "PWY-5846", "PWY-6409", "PWY-6899", "PWY-7018", "PWY-7403", "PWY-7430", "PWY-7496", "PWY-7571", "PWY-7652", "PWY-7771", "PWY-7821", "PWY-7850", "PWY-8229", "PWY-8293", "PWY-8402", "PWY-8418", "PW...

[ "EC:3.5.1.-", "GP:GenProp0927", "GP:GenProp1505", "METACYC:PWY-1822", "METACYC:PWY-5497", "METACYC:PWY-5784", "METACYC:PWY-5846", "METACYC:PWY-6409", "METACYC:PWY-6899", "METACYC:PWY-7018", "METACYC:PWY-7403", "METACYC:PWY-7430", "METACYC:PWY-7496", "METACYC:PWY-7571", "METACYC:PWY-7652"...

25

[ "1uan", "2ixd", "6p2t", "6ull" ]

4

[ "PUB00055031" ]

[ "20308541" ]

[ "Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli." ]

[ 2010 ]

1

[ "IPR003737" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Promethearchaeaceae", "unclassified sequences" ]

[ 3458, 10, 2, 35 ]

4

[]

0

true

Family

Bacillithiol biosynthesis deacetylase, BshB1

Bacillithiol_biosynth_BshB1

4

IPR023843

23,843

CRISPR-associated protein Cas1, cyanobacteria-type

CRISPR-assoc_Cas1_cyanobact

Family

271

false

This entry describes a type of Cas1 proteins found mainly in cyanobacteria and some archaeal species, including Methanospirillum hungatei CRISPR-associated endonuclease Cas1 4. The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas ...

[ "GO:0004520", "GO:0046872", "GO:0043571" ]

[ "DNA endonuclease activity", "metal ion binding", "maintenance of CRISPR repeat elements" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR04093" ]

[ "cas1_CYANO" ]

[ 271 ]

1

[ "GP" ]

[ "GenProp0685" ]

[ "GP:GenProp0685" ]

1

[ "7cr6", "7cr8" ]

2

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2011, 2014 ]

5

[ "IPR002729" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriota", "hydrothermal vent metagenome" ]

[ 250, 20, 1 ]

3

[]

0

true

Family

CRISPR-associated protein Cas1, cyanobacteria-type

CRISPR-assoc_Cas1_cyanobact

1

IPR023844

23,844

CRISPR-associated protein Cas1, MYXAN subtype

CRISPR-assoc_Cas1_MYXAN

Family

114

false

This entry represents the MYXAN subtype of the Cas1 endonuclease. Species with this type of CRISPR system include Myxococcus xanthus, Cyanothece sp., Leptospira interrogans, Sorangium cellulosum, and Anabaena variabilis ATCC 29413. The entry also detects Cas4/Cas1 fusion proteins. The CRISPR-Cas system is a prokaryotic...

[ "GO:0004520", "GO:0046872", "GO:0043571" ]

[ "DNA endonuclease activity", "metal ion binding", "maintenance of CRISPR repeat elements" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR03983" ]

[ "cas1_MYXAN" ]

[ 114 ]

1

[ "GP" ]

[ "GenProp0922" ]

[ "GP:GenProp0922" ]

1

[]

0

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2011, 2014 ]

5

[ "IPR002729" ]

[]

1

0

1

[ "Bacteria" ]

[ 114 ]

1

[]

0

true

Family

CRISPR-associated protein Cas1, MYXAN subtype

CRISPR-assoc_Cas1_MYXAN

3

IPR023845

23,845

Domain of unknown function DUF3817, transmembrane

DUF3817_TM

Domain

11,509

false

This domain is associated with, strictly bacterial integral membrane proteins. It occurs in proteins that on rare occasions are fused to transporter domains such as the major facilitator superfamily domain. Of three invariant residues, two occur as a His-Gly dipeptide in the middle of three predicted transmembrane heli...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF12823", "TIGR03954" ]

[ "DUF3817", "integ_memb_HG" ]

[ 11509, 11385 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 11337, 4, 168 ]

3

[]

0

true

Domain

Domain of unknown function DUF3817, transmembrane

DUF3817_TM

2

IPR023846

23,846

Conserved hypothetical protein CHP04042, MSMEG0570

CHP04042_MSMEG0570

Family

1,199

false

This entry represents small proteins of about 90 residues long that have no detectable homologues outside this family. These proteins serve as markers for an eight-gene region whose overall function is unknown. One member of the cluster is a radical SAM protein with some similarity to enzymes of cofactor biosynthesis, ...

[]

0

[ "NCBIFAM" ]

[ "TIGR04042" ]

[ "MSMEG_0570_fam" ]

[ 1199 ]

1

[ "GP" ]

[ "GenProp0939" ]

[ "GP:GenProp0939" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "freshwater metagenome" ]

[ 1195, 4 ]

2

[]

0

true

Family

Conserved hypothetical protein CHP04042, MSMEG0570

CHP04042_MSMEG0570

5

IPR023847

23,847

MSMEG_0572 family nitrogen starvation response protein

MSMEG0572

Family

1,349

false

This entry describes a family of proteins with remote similarity to the DsrE/DsrF-like family (see ). All members are found in a context of at least seven genes that includes a radical SAM protein, suggesting biosynthesis. The system is sparsely but broadly distributed in bacteria, including Actinobacteria, Proteobacte...

[]

0

[ "NCBIFAM" ]

[ "TIGR04044" ]

[ "MSMEG_0572_fam" ]

[ 1349 ]

1

[ "GP" ]

[ "GenProp0939" ]

[ "GP:GenProp0939" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1336, 13 ]

2

[]

0

true

Family

MSMEG_0572 family nitrogen starvation response protein

MSMEG0572

4

IPR023848

23,848

TasA anchoring/assembly protein

TasA

Family

210

false

This entry represents a group of bacterial proteins, including TasA from Bacillus subtilis. Microbes construct architecturally complex and ordered communities called biofilms through production of an extracellular matrix composed of an exopolysaccharide and the amyloid-like protein TasA [ ]. TasA has the propensity to ...

[ "GO:0097311" ]

[ "bacterial biofilm matrix" ]

[ "cellular_component" ]

1

[ "NCBIFAM" ]

[ "TIGR04087" ]

[ "YqxM_for_SipW" ]

[ 210 ]

1

[]

0

[ "6hqc", "6qay", "8aif" ]

3

[ "PUB00089801", "PUB00089802", "PUB00089803" ]

[ "24488317", "16430696", "20080671" ]

[ "Functional analysis of the accessory protein TapA in Bacillus subtilis amyloid fiber assembly.", "A major protein component of the Bacillus subtilis biofilm matrix.", "Amyloid fibers provide structural integrity to Bacillus subtilis biofilms." ]

[ 2014, 2006, 2010 ]

3

[]

0

null

[ "Bacteria" ]

[ 210 ]

1

[]

0

true

Family

TasA anchoring/assembly protein

TasA

7

IPR023849

23,849

TQXA domain

TQXA_dom

Domain

2,508

false

This entry describes a domain of about 40 residues with an invariant TQ dipeptide in an almost invariant TQxA[VI]W motif. This domain occurs in surface-expressed proteins of Gram-positive bacteria, many of which are anchored by LPXTG-containing sortase target domains. Proteins in this entry may also have the Cna protei...

[]

0

[ "NCBIFAM" ]

[ "TIGR03934" ]

[ "TQXA_dom" ]

[ 2508 ]

1

[]

0

[ "2xi9", "2xic", "2xid", "4bug", "4c0z", "5a0d", "5a0g", "5a0l", "5dcq", "6fwv" ]

10

[ "PUB00078721" ]

[ "20729215" ]

[ "A highly unusual thioester bond in a pilus adhesin is required for efficient host cell interaction." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 2507, 1 ]

2

[]

0

true

Domain

TQXA domain

TQXA_dom

7

IPR023851

23,851

Transcriptional regulator, TetR-type

Tscrpt_reg_TetR-type

Family

1,018

false

Members of this family are transcriptional regulators belonging to the TetR-family. They occur in genome contexts near members of family .

[]

0

[ "NCBIFAM" ]

[ "TIGR03968" ]

[ "mycofact_TetR" ]

[ 1018 ]

1

[ "GP" ]

[ "GenProp0917" ]

[ "GP:GenProp0917" ]

1

[ "2rae", "8x0a" ]

2

[]

0

[ "IPR050109" ]

[]

1

0

1

[ "Actinomycetota", "metagenomes" ]

[ 1009, 9 ]

2

[]

0

true

Family

Transcriptional regulator, TetR-type

Tscrpt_reg_TetR-type

6

IPR023852

23,852

Metalloproteinase lipoprotein, BF0631

Metalloproteinase_lipop_BF0631

Family

257

false

Members of this protein family are predicted to be zinc-dependent metalloproteinases, related to ulilysin and other members of the pappalysin family. They are found in the genera Bacteriodes and Prevotella. They are predicted to occur as lipoproteins.

[]

0

[ "NCBIFAM" ]

[ "TIGR03952" ]

[ "metzin_BF0631" ]

[ 257 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteroidales", "gut metagenome" ]

[ 255, 2 ]

2

[]

0

true

Family

Metalloproteinase lipoprotein, BF0631

Metalloproteinase_lipop_BF0631

6

IPR023854

23,854

Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB

PGA_deacetylase_PgaB

Family

1,896

false

Two well-characterised systems produce polysaccharide based on N-acetyl-D-glucosamine in straight chains with beta-1,6 linkages. These are encoded by the icaADBC operon in Staphylococcus species and the pgaABCD operon in Gram-negative bacteria such as E. coli. Both systems include a putative polysaccharide deacetylase....

[ "GO:0016810", "GO:0043708" ]

[ "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "cell adhesion involved in biofilm formation" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03938" ]

[ "deacetyl_PgaB" ]

[ 1896 ]

1

[ "GP" ]

[ "GenProp0907" ]

[ "GP:GenProp0907" ]

1

[ "3vus", "4f9d", "4f9j", "4p7l", "4p7n", "4p7o", "4p7q", "4p7r", "4u10", "5bu6", "6au1" ]

11

[ "PUB00055021", "PUB00055022" ]

[ "15090514", "18359807" ]

[ "The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation.", "Roles of pgaABCD genes in synthesis, modification, and export of the Escherichia coli biofilm adhesin poly-beta-1,6-N-acetyl-D-glucosamine." ]

[ 2004, 2008 ]

2

[]

0

null

[ "Bacteria", "Fungi", "ecological metagenomes" ]

[ 1888, 3, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB

PGA_deacetylase_PgaB

5

IPR023858

23,858

Radical S-adenosyl methionine enzyme HcgA-like

HcgA-like

Family

93

false

This protein family includes HcgA from Methanococcus maripaludis (MMP0126, ) and similar prokaryotic proteins. HcgA is a radical S-adenosyl methionine enzyme involved in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor [ ].

[]

0

[ "SFLD", "NCBIFAM" ]

[ "SFLDF00330", "TIGR03957" ]

[ "HMD_cofactor_maturase_(HmdB-li", "rSAM_HmdB" ]

[ 92, 83 ]

2

[ "GP" ]

[ "GenProp0915" ]

[ "GP:GenProp0915" ]

1

[]

0

[ "PUB00055023", "PUB00158981" ]

[ "19897660", "36264001" ]

[ "Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor.", "The Function of Two Radical-SAM Enzymes, HcgA and HcgG, in the Biosynthesis of the [Fe]-Hydrogenase Cofactor." ]

[ 2010, 2022 ]

2

[]

0

null

[ "Bacteria", "Methanobacteriota", "bioreactor metagenome" ]

[ 11, 80, 2 ]

3

[]

0

true

Family

Radical S-adenosyl methionine enzyme HcgA-like

HcgA-like

4

IPR023860

23,860

[FeFe]-hydrogenase system regulator TM1266

FeFe-hyd_TM1266

Family

1,548

false

Members of this protein family occur as part of a system for producing iron-only hydrogenases, dependent on radical SAM proteins HydE and HydG and GTPase HydF. One member of this family, TM_1266 from Thermotoga maritima, has a known crystal structure. The small size, about 80 residues, and a distant relationship to the...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF21699", "TIGR03959" ]

[ "TM1266-like", "hyd_TM1266" ]

[ 1548, 1365 ]

2

[ "GP" ]

[ "GenProp0914" ]

[ "GP:GenProp0914" ]

1

[ "2nzc" ]

1

[]

0

[]

0

null

[ "Bacteria", "Gonapodya prolifera (strain JEL478)", "metagenomes" ]

[ 1516, 1, 31 ]

3

[]

0

true

Family

[FeFe]-hydrogenase system regulator TM1266

FeFe-hyd_TM1266

5

IPR023861

23,861

Chloride channel, ClcA

Cl-channel_ClcA

Family

1,161

false

This entry represents a proton-coupled chloride transporter, which functions as an antiport system and exchanges two chloride ions for one proton. It probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) resp...

[ "GO:0015108", "GO:0006821", "GO:0005886" ]

[ "chloride transmembrane transporter activity", "chloride transport", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP" ]

[ "MF_01128" ]

[ "CLC_ClcA" ]

[ 1161 ]

1

[]

0

[ "1kpk", "1kpl", "2exw", "2exy", "2ht2", "2ht3", "2ht4", "2htk", "2htl", "3ejy", "3ejz", "6ad7", "6ad8", "6ada", "6adb", "6k5d", "6k5f", "7cvs", "7cvt", "7n8p", "7n9w", "7rnx", "7ro0", "7rp5", "7rp6", "7rq7", "7rsb", "8ga0" ]

28

[ "PUB00040470", "PUB00041255", "PUB00055002", "PUB00055104" ]

[ "16341087", "16905147", "12384697", "14985752" ]

[ "Ion-binding properties of the ClC chloride selectivity filter.", "Uncoupling of a CLC Cl-/H+ exchange transporter by polyatomic anions.", "A biological role for prokaryotic ClC chloride channels.", "Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels." ]

[ 2006, 2006, 2002, 2004 ]

4

[ "IPR001807" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 1161 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Chloride channel, ClcA

Cl-channel_ClcA

8

IPR023862

23,862

Conserved hypothetical protein CHP03960, radical SAM

CHP03960_rSAM

Family

4,881

false

This entry describes a radical SAM protein, or protein region, regularly found paired with or fused to a region described by . PSI-BLAST analysis of suggests a relationship to the tRNA pseudouridine synthase TruA, suggesting that this system may act in RNA modification.

[]

0

[ "NCBIFAM" ]

[ "TIGR03960" ]

[ "rSAM_fuse_unch" ]

[ 4881 ]

1

[ "GP" ]

[ "GenProp0916" ]

[ "GP:GenProp0916" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4756, 33, 92 ]

3

[]

0

true

Family

Conserved hypothetical protein CHP03960, radical SAM

CHP03960_rSAM

8

IPR023863

23,863

Archaeal radical SAM protein, PTO1314 family

rSAM_PTO1314

Family

59

false

Members of this protein family average about 340 residues in length, with a radical SAM domain in the N-terminal 200 residues. The taxonomic distribution is restricted to non-methanogenic archaea, including Picrophilus torridus (locus PTO1314), Sulfolobus sp., Thermoplasma sp., Picrophilus torridus, and Metallosphaera ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03961" ]

[ "rSAM_PTO1314" ]

[ 59 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "mine drainage metagenome" ]

[ 57, 2 ]

2

[]

0

true

Family

Archaeal radical SAM protein, PTO1314 family

rSAM_PTO1314

8

IPR023865

23,865

Aliphatic acid kinase, short-chain, conserved site

Aliphatic_acid_kinase_CS

Conserved_site

29,201

false

Acetate kinase, which is predominantly found in microorganisms, facilitates the production of acetyl-CoA by phosphorylating acetate in the presence of ATP and a divalent cation [ , , ]. The enzyme is important in the process of glycolysis, enzyme levels being increased in the presence of excess glucose. The growth of a...

[ "GO:0016301", "GO:0016774", "GO:0016310" ]

[ "kinase activity", "phosphotransferase activity, carboxyl group as acceptor", "phosphorylation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PROSITE", "PROSITE" ]

[ "PS01075", "PS01076" ]

[ "ACETATE_KINASE_1", "ACETATE_KINASE_2" ]

[ 26163, 25256 ]

2

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.2", "2.7.2.1", "PWY-5482", "PWY-5485", "PWY-5497", "PWY-8015", "PWY-8086", "PWY-8303", "PWY-8377" ]

[ "EC:2.7.2", "EC:2.7.2.1", "METACYC:PWY-5482", "METACYC:PWY-5485", "METACYC:PWY-5497", "METACYC:PWY-8015", "METACYC:PWY-8086", "METACYC:PWY-8303", "METACYC:PWY-8377" ]

9

[ "1g99", "1saz", "1tuu", "1tuy", "1x3m", "1x3n", "1x9j", "2e1y", "2e1z", "2e20", "2iir", "3khy", "3p4i", "3r9p", "3sk3", "3slc", "4dq8", "4fwk", "4fwl", "4fwm", "4fwn", "4fwo", "4fwp", "4fwq", "4fwr", "4fws", "4h0p", "4ijn", "4iz9", "4xh1", "4xh4", "4xh5"...

40

[ "PUB00001831", "PUB00002232", "PUB00065155" ]

[ "8396545", "8226682", "23031654" ]

[ "Cloning and sequence analysis of the genes encoding phosphotransbutyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052.", "Regulation of the Bacillus subtilis acetate kinase gene by CcpA.", "Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): identifica...

[ 1993, 1993, 2012 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Siphoviridae sp. ctX581", "unclassified sequences" ]

[ 27307, 1566, 40, 1, 287 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2, 1 ]

2

true

Conserved_site

Aliphatic acid kinase, short-chain, conserved site

Aliphatic_acid_kinase_CS

5

IPR023866

23,866

2,3-diaminopropionate biosynthesis protein SbnB

SbnB

Family

1,822

false

Members of this protein family are probable NAD-dependent dehydrogenases related to the alanine dehydrogenase of Archaeoglobus fulgidus (see ) [ ] and, more distantly, to ornithine cyclodeaminase. Members include the staphylobactin biosynthesis protein SbnB. Together with SbnA, SbnB is encoded by the staphyloferrin B b...

[ "GO:0016639", "GO:0019290" ]

[ "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor", "siderophore biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03944" ]

[ "dehyd_SbnB_fam" ]

[ 1822 ]

1

[ "GP" ]

[ "GenProp0908" ]

[ "GP:GenProp0908" ]

1

[ "4m54", "4mp3", "4mp6", "4mp8", "4mpd" ]

5

[ "PUB00029492", "PUB00083270" ]

[ "15313611", "24485762" ]

[ "Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin.", "Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor." ]

[ 2004, 2014 ]

2

[ "IPR003462" ]

[]

1

0

1

[ "Bacteria", "Tilletia caries" ]

[ 1821, 1 ]

2

[]

0

true

Family

2,3-diaminopropionate biosynthesis protein SbnB

SbnB

5

IPR023867

23,867

Anaerobic sulphatase maturase, radical SAM

Sulphatase_maturase_rSAM

Family

18,296

false

Proteins in this entry include ChuR from Bacteroides thetaiotaomicron and AnSME (also known as CPF_0616) from Clostridium perfringens. ChuR is involved in 'Ser-type' sulfatase maturation under anaerobic conditions [ ], while AnSME is involved in 'Cys-type' sulfatase maturation under anaerobic conditions [ ]. Members of...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PANTHER", "SFLD" ]

[ "PTHR43273", "SFLDG01384" ]

[ "", "thioether_bond_formation_requi" ]

[ 17818, 11566 ]

2

[ "GP" ]

[ "GenProp0918" ]

[ "GP:GenProp0918" ]

1

[ "4k36", "4k37", "4k38", "4k39", "5wgg", "5why", "8vpo", "9gm3", "9gmc" ]

9

[ "PUB00055025", "PUB00099549" ]

[ "18408004", "23477283" ]

[ "Anaerobic sulfatase-maturating enzymes, first dual substrate radical S-adenosylmethionine enzymes.", "Further characterization of Cys-type and Ser-type anaerobic sulfatase maturating enzymes suggests a commonality in the mechanism of catalysis." ]

[ 2008, 2013 ]

2

[]

[ "IPR023819", "IPR023886", "IPR024001", "IPR024016", "IPR024018", "IPR024023", "IPR024025", "IPR026335", "IPR026357", "IPR026407", "IPR026412", "IPR026423", "IPR026426", "IPR030989", "IPR034485", "IPR034491", "IPR034547" ]

0

17

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 588, 17209, 71, 121, 307 ]

5

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Family

Anaerobic sulphatase maturase, radical SAM

Sulphatase_maturase_rSAM

2

IPR023868

23,868

7-carboxy-7-deazaguanine synthase, Clostridial form

7-CO-7-deazaGua_synth_put_Clo

Family

341

false

This entry represents Clostridial form of the 7-carboxy-7-deazaguanine synthases. They are encoded in preQ0 operons found in species that lack members of the related protein family . 7-deazapurines are compounds that contain pyrrolopyrimidine functional groups (similar to purines, but lacking one of the nitrogens in th...

[]

0

[ "NCBIFAM" ]

[ "TIGR03963" ]

[ "rSAM_QueE_Clost" ]

[ 341 ]

1

[]

0

[]

0

[ "PUB00035932", "PUB00056816" ]

[ "14660578", "19354300" ]

[ "Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine.", "The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps." ]

[ 2004, 2009 ]

2

[ "IPR024924" ]

[]

1

0

1

[ "Bacteria", "metagenomes", "unclassified Caudoviricetes" ]

[ 337, 2, 2 ]

3

[]

0

true

Family

7-carboxy-7-deazaguanine synthase, Clostridial form

7-CO-7-deazaGua_synth_put_Clo

2

IPR023869

23,869

tRNA adenosine deaminase-associated protein

tRNA_Adeno_NH3ase_assoc

Family

3,405

false

This entry describes a family of proteins about 200 amino acids in length with only five invariant residues, including an Arg, a Ser-Asp pair, and two Gly residues. Members always are found exclusively in Actinobacteria, and always adjacent to homologues of TadA, a tRNA-specific adenosine deaminase from Escherichia col...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF27101", "TIGR03941" ]

[ "Rv3753c", "tRNA_deam_assoc" ]

[ 3401, 3404 ]

2

[]

0

[]

0

[ "PUB00162132" ]

[ "21969609" ]

[ "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry." ]

[ 2011 ]

1

[]

0

null

[ "Actinomycetes", "metagenomes" ]

[ 3312, 93 ]

2

[]

0

true

Family

tRNA adenosine deaminase-associated protein

tRNA_Adeno_NH3ase_assoc

6

IPR023870

23,870

Poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA

PGA_export_porin_PgaA

Family

1,577

false

Members of this protein family are the poly-beta-1,6 N-acetyl-D-glucosamine (PGA) export porin PgaA of Gram-negative bacteria. There is no counterpart in the poly-beta-1,6 N-acetyl-D-glucosamine biosynthesis systems of Gram-positive bacteria such as Staphylococcus epidermidis. The PGA polysaccharide adhesin is a critic...

[ "GO:1901515" ]

[ "poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03939" ]

[ "PGA_TPR_OMP" ]

[ 1577 ]

1

[ "GP" ]

[ "GenProp0907" ]

[ "GP:GenProp0907" ]

1

[ "4y25" ]

1

[ "PUB00055016", "PUB00055021", "PUB00055022" ]

[ "19460094", "15090514", "18359807" ]

[ "Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress.", "The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation.", "Roles of pgaABCD genes in synthesis, modification, and export of the Escherichia coli biof...

[ 2009, 2004, 2008 ]

3

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome", "leotiomyceta" ]

[ 1572, 3, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA

PGA_export_porin_PgaA

6

IPR023871

23,871

Mycofactocin precursor peptide peptidase

MftE

Family

1,228

false

This entry represents the Mycofactocin precursor peptide peptidase MftE, a peptidase involved in the biosynthesis of the enzyme cofactor mycofactocin (MFT) [ ]. It catalyses the cleavage of the MftC-modified MftA peptide to liberate its final two residues, which consist of a cross-linked valine-decarboxylated tyrosine ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03964" ]

[ "mycofact_creat" ]

[ 1228 ]

1

[ "EC", "GP", "METACYC" ]

[ "3.4.14.14", "GenProp0917", "PWY-8122" ]

[ "EC:3.4.14.14", "GP:GenProp0917", "METACYC:PWY-8122" ]

3

[]

0

[ "PUB00096692", "PUB00096693", "PUB00096694" ]

[ "31113891", "33014324", "30183269" ]

[ "Mycofactocin Is Associated with Ethanol Metabolism in Mycobacteria.", "Structure elucidation of the redox cofactor mycofactocin reveals oligo-glycosylation by MftF.", "Mycofactocin Biosynthesis Proceeds through 3-Amino-5-[( p-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); Direct Observation of MftE...

[ 2019, 2020, 2018 ]

3

[ "IPR003785" ]

[]

1

0

1

[ "Bacteria", "Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / JCM 9101 / NCIMB 13204 / VKM B-1734 / 4k)", "metagenomes" ]

[ 1180, 1, 47 ]

3

[]

0

true

Family

Mycofactocin precursor peptide peptidase

MftE

9

IPR023872

23,872

Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase

PNAG_deacetylase

Family

111

false

A common motif in bacterial biosynthesis of polysaccharide for export is modification that follows polymerisation. This entry describes a family of polysaccharide N-deacetylases that act on poly-beta-1,6-N-acetyl-D-glucosamine as produced by Staphylococcus epidermidis and S. aureus. The end product in these species is ...

[ "GO:0016811" ]

[ "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03933" ]

[ "PIA_icaB" ]

[ 111 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.5.1.-", "PWY-1822", "PWY-5497", "PWY-5784", "PWY-5846", "PWY-6409", "PWY-6899", "PWY-7018", "PWY-7403", "PWY-7430", "PWY-7496", "PWY-7571", "PWY-7652", "PWY-7771", "PWY-7821", "PWY-7850", "PWY-8229", "PWY-8293", "PWY-8402", "PWY-8418", "PWY-8431", "PWY-8432", "PWY-8453...

[ "EC:3.5.1.-", "METACYC:PWY-1822", "METACYC:PWY-5497", "METACYC:PWY-5784", "METACYC:PWY-5846", "METACYC:PWY-6409", "METACYC:PWY-6899", "METACYC:PWY-7018", "METACYC:PWY-7403", "METACYC:PWY-7430", "METACYC:PWY-7496", "METACYC:PWY-7571", "METACYC:PWY-7652", "METACYC:PWY-7771", "METACYC:PWY-7...

23

[]

0

[ "PUB00055027" ]

[ "10496925" ]

[ "The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation." ]

[ 1999 ]

1

[]

0

null

[ "Bacilli", "human gut metagenome" ]

[ 110, 1 ]

2

[]

0

true

Family

Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase

PNAG_deacetylase

5

IPR023873

23,873

[FeFe]-hydrogenase H-cluster maturation GTPase HydF

FeFe-hyd_GTPase_HydF

Family

2,158

false

This entry describes the family of the [Fe] hydrogenase maturation protein HypF as characterised in Chlamydomonas reinhardtii. It is found in an operon with radical SAM proteins HydE and HydG in numerous bacteria. It has GTPase activity, can bind an 4Fe-4S cluster, and is essential for hydrogenase activity [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR03918" ]

[ "GTP_HydF" ]

[ 2158 ]

1

[ "GP" ]

[ "GenProp0914" ]

[ "GP:GenProp0914" ]

1

[ "3qq5", "5kh0", "5lad" ]

3

[ "PUB00055029" ]

[ "15082711" ]

[ "Discovery of two novel radical S-adenosylmethionine proteins required for the assembly of an active [Fe] hydrogenase." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2138, 20 ]

2

[]

0

true

Family

[FeFe]-hydrogenase H-cluster maturation GTPase HydF

FeFe-hyd_GTPase_HydF

6

IPR023874

23,874

DNA modification/repair radical SAM protein, putative

DNA_rSAM_put

Family

6,169

false

This entry represents a family of uncharacterised protein of about 400 amino acids in length that contains a radical SAM domain in the N-terminal half. Members of this family are present in about twenty percent of prokaryotic genomes, always paired with a member of the conserved hypothetical protein . Roughly forty per...

[]

0

[ "SFLD", "NCBIFAM" ]

[ "SFLDG01102", "TIGR03916" ]

[ "Uncharacterised_Radical_SAM_Su", "rSAM_link_UDG" ]

[ 6142, 5885 ]

2

[ "GP" ]

[ "GenProp0903" ]

[ "GP:GenProp0903" ]

1

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctYaH2", "unclassified sequences" ]

[ 135, 5968, 7, 1, 58 ]

5

[]

0

true

Family

DNA modification/repair radical SAM protein, putative

DNA_rSAM_put

1

IPR023875

23,875

DNA repair protein, putative

DNA_repair_put

Family

6,076

false

This entry represents a family of conserved hypothetical proteins that almost invariably pair with an uncharacterised radical SAM protein. The pair occurs in about twenty percent of completed prokaryotic genomes. About forty percent of the members of this family occur as fusion proteins, where the C-terminal domain bel...

[]

0

[ "NCBIFAM" ]

[ "TIGR03915" ]

[ "SAM_7_link_chp" ]

[ 6076 ]

1

[ "GP" ]

[ "GenProp0903" ]

[ "GP:GenProp0903" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "Siphoviridae sp. ctYaH2", "unclassified sequences" ]

[ 6016, 4, 1, 55 ]

4

[]

0

true

Family

DNA repair protein, putative

DNA_repair_put

1

IPR023877

23,877

Pyrrolysyl-tRNA ligase, C-terminal

Pyrrolysyl-tRNA_ligase_C

Domain

147

false

PylS is the enzyme responsible for charging the pyrrolysine tRNA, PylT, by ligating a free molecule of pyrrolysine. Pyrrolysine is encoded at an in-frame UAG (amber) at least in several corrinoid-dependent methyltransferases of the archaeal genera Methanosarcina and Methanococcoides, such as trimethylamine methyltransf...

[ "GO:0004812" ]

[ "aminoacyl-tRNA ligase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR02367" ]

[ "PylS_Cterm" ]

[ 147 ]

1

[ "EC" ]

[ "6.1.1.26" ]

[ "EC:6.1.1.26" ]

1

[ "2e3c", "2q7e", "2q7g", "2q7h", "2zce", "2zim", "2zin", "2zio", "2zni", "2znj", "3dsq", "3qtc", "3vqv", "3vqw", "3vqx", "3vqy", "4bw9", "4bwa", "4ch3", "4ch4", "4ch5", "4ch6", "4cs2", "4cs3", "4cs4", "4q6g", "4tqd", "4tqf", "4zib", "5k1p", "5k1x", "6aac"...

68

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriati", "ecological metagenomes" ]

[ 69, 76, 2 ]

3

[]

0

true

Domain

Pyrrolysyl-tRNA ligase, C-terminal

Pyrrolysyl-tRNA_ligase_C

3

IPR023878

23,878

Pyrrolysyl-tRNA ligase, N-terminal

Pyrrolysyl-tRNA_ligase_N

Domain

134

false

PylS is the enzyme responsible for charging the pyrrolysine tRNA, PylT, by ligating a free molecule of pyrrolysine [ , ]. Pyrrolysine is encoded at an in-frame UAG (amber) at least in several corrinoid-dependent methyltransferases of the archaeal genera Methanosarcina and Methanococcoides, such as trimethylamine methyl...

[ "GO:0004812" ]

[ "aminoacyl-tRNA ligase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR03912" ]

[ "PylS_Nterm" ]

[ 134 ]

1

[ "EC" ]

[ "6.1.1.26" ]

[ "EC:6.1.1.26" ]

1

[ "5ud5", "5v6x" ]

2

[ "PUB00017763", "PUB00017765" ]

[ "15329732", "15314242" ]

[ "Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo.", "An aminoacyl-tRNA synthetase that specifically activates pyrrolysine." ]

[ 2004, 2004 ]

2

[]

0

null

[ "Bacteria", "Methanosarcinaceae", "bioreactor metagenome" ]

[ 70, 63, 1 ]

3

[]

0

true

Domain

Pyrrolysyl-tRNA ligase, N-terminal

Pyrrolysyl-tRNA_ligase_N

4

IPR023879

23,879

Quinohemoprotein amine dehydrogenase, beta subunit

QH-AmDH_bsu

Family

460

false

Quinohemoprotein amine dehydrogenases (QHNDH) ) are enzymes produced in the periplasmic space of certain Gram-negative bacteria, such as Paracoccus denitrificans and Pseudomonas putida, in response to primary amines, including n-butylamine and benzylamine. QHNDH catalyses the oxidative deamination of a wide range of al...

[]

0

[ "NCBIFAM" ]

[ "TIGR03907" ]

[ "QH_beta" ]

[ 460 ]

1

[ "GP" ]

[ "GenProp0902" ]

[ "GP:GenProp0902" ]

1

[ "1jju", "1jmx", "1jmz", "1pby" ]

4

[ "PUB00013277", "PUB00022422", "PUB00035735", "PUB00035736", "PUB00035737" ]

[ "11704672", "12925784", "15234267", "12974623", "12427036" ]

[ "Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida. Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges.", "Structure of the phenylhydrazine adduct of the quinohemoprotein amine dehydrogenase from Paracoccus denitrificans at 1.7 A resolution.", ...

[ 2002, 2003, 2004, 2003, 2002 ]

5

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 453, 7 ]

2

[]

0

true

Family

Quinohemoprotein amine dehydrogenase, beta subunit

QH-AmDH_bsu

9

IPR023880

23,880

Benzylsuccinate synthase activating enzyme

Benzylsucc_Synthase_activating

Family

14

false

Proteins in this entry are thought to be radical SAM benzylsuccinate synthase-activating enzymes. They are a glycyl radical active site-creating enzyme related to pyruvate formate lyase-activating enzyme and additional uncharacterised homologues which activate additional glycyl radical-containing enzymes [ , ].

[]

0

[ "NCBIFAM" ]

[ "TIGR04003" ]

[ "rSAM_BssD" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00017117", "PUB00055030" ]

[ "9632263", "8706665" ]

[ "Biochemical and genetic characterization of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism.", "Evidence that anaerobic oxidation of toluene in the denitrifying bacterium Thauera aromatica is initiated by formation of benzylsu...

[ 1998, 1996 ]

2

[ "IPR040074" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 14 ]

1

[]

0

true

Family

Benzylsuccinate synthase activating enzyme

Benzylsucc_Synthase_activating

1

IPR023881

23,881

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA

Thiol_BshA

Family

4,024

false

Members of this protein family are BshA, a glycosyltransferase required for bacillithiol biosynthesis. BshA catalyzes the formation of the first intermediate, GlcNAc-Mal, using L-malate and the glucosamine donor substrate UDP-N-acetylglucosamine (UDP-GlcNAc) as substrates. Bacillithiol is a low-molecular-weight thiol, ...

[ "GO:0016757", "GO:0071793" ]

[ "glycosyltransferase activity", "bacillithiol biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03999" ]

[ "thiol_BshA" ]

[ 4024 ]

1

[ "GP", "GP" ]

[ "GenProp0927", "GenProp1505" ]

[ "GP:GenProp0927", "GP:GenProp1505" ]

2

[ "2jjm", "3mbo", "5d00", "5d01", "6d9t", "6n1x" ]

6

[ "PUB00015209", "PUB00055031", "PUB00079860" ]

[ "12691742", "20308541", "16037492" ]

[ "An evolving hierarchical family classification for glycosyltransferases.", "Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.", "Structures and mechanisms of glycosyltransferases." ]

[ 2003, 2010, 2006 ]

3

[]

0

null

[ "Bacteria", "Candidatus Heimdallarchaeum", "Eukaryota", "metagenomes" ]

[ 3980, 2, 13, 29 ]

4

[]

0

true

Family

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA

Thiol_BshA

6

IPR023882

23,882

Colanic acid biosynthesis WcaM

Colanic_acid_synth_WcaM

Family

1,517

false

This protein of uncharacterised function is the final gene in the conserved colanic acid biosynthesis cluster observed in Enterobacteraceae [ ].

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF27800", "TIGR04004" ]

[ "WcaM", "WcaM" ]

[ 1517, 1186 ]

2

[]

0

[ "6e0v", "6e0w" ]

2

[ "PUB00008202" ]

[ "8759852" ]

[ "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "Viruses", "human gut metagenome" ]

[ 1448, 1, 65, 3 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Colanic acid biosynthesis WcaM

Colanic_acid_synth_WcaM

3

IPR023883

23,883

Conserved hypothetical protein CHP03980, redox-disulphide

CHP03980_redox-disulphide

Family

2,953

false

Members of this protein family all contain an apparent redox-active disulphide. In at least one family member, a cysteine in the CXXC motif is substituted by a selenocysteine. The family is sometimes found adjacent to (and, on occasion, fused with) members of the hybrid-cluster (prismane) family or the nitrite/sulphite...

[]

0

[ "PANTHER", "NCBIFAM" ]

[ "PTHR39341", "TIGR03980" ]

[ "", "prismane_assoc" ]

[ 2610, 2914 ]

2

[]

0

[ "2k53", "2k5e" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Trichomonas vaginalis", "metagenomes" ]

[ 64, 2808, 2, 79 ]

4

[]

0

true

Family

Conserved hypothetical protein CHP03980, redox-disulphide

CHP03980_redox-disulphide

7

IPR023884

23,884

Colanic acid biosynthesis, glycosyl transferase, WcaL

Colanic_acid_synth_WcaL

Family

1,127

false

This entry represents one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR04005" ]

[ "wcaL" ]

[ 1127 ]

1

[]

0

[]

0

[ "PUB00008202" ]

[ "8759852" ]

[ "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid." ]

[ 1996 ]

1

[]

0

null

[ "Beauveria bassiana D1-5", "Gammaproteobacteria", "marine sediment metagenome" ]

[ 1, 1125, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Colanic acid biosynthesis, glycosyl transferase, WcaL

Colanic_acid_synth_WcaL

7

IPR023885

23,885

4Fe4S-binding SPASM domain

4Fe4S-binding_SPASM_dom

Domain

34,553

false

This domain contains regions binding additional 4Fe4S clusters found in various radical SAM proteins C-terminal to the domain described by . Radical SAM enzymes with this domain tend to be involved in protein modification, including anaerobic sulphatase maturation proteins, a quinohemoprotein amine dehydrogenase biogen...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF13186", "TIGR04085" ]

[ "SPASM", "rSAM_more_4Fe4S" ]

[ 27780, 24264 ]

2

[ "EC", "METACYC" ]

[ "1.21.98.4", "PWY-6420" ]

[ "EC:1.21.98.4", "METACYC:PWY-6420" ]

2

[ "4k36", "4k37", "4k38", "4k39", "4m7s", "4m7t", "5v1q", "5v1s", "5v1t", "5wgg", "5why", "6c8v", "6efn" ]

13

[ "PUB00055033", "PUB00055045", "PUB00055953" ]

[ "12817086", "21223593", "21478363" ]

[ "Cannibalism by sporulating bacteria.", "Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.", "Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target pe...

[ 2003, 2011, 2011 ]

3

[]

[ "IPR047207", "IPR047602" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2108, 31236, 74, 106, 1029 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 2, 2 ]

2

true

Domain

4Fe4S-binding SPASM domain

4Fe4S-binding_SPASM_dom

1

IPR023886

23,886

Quinohemoprotein amine dehydrogenase, gamma subunit maturation protein

QH-AmDH_gsu_maturation

Family

515

false

Members of this protein family are radical SAM enzymes responsible for post-translational modifications to the gamma subunit of quinohemoprotein amine dehydrogenases. It has been suggested that this protein is responsible for intrapeptidyl thioether cross-linking rather than cysteine tryptophylquinone biogenesis in the...

[]

0

[ "SFLD", "NCBIFAM" ]

[ "SFLDF00336", "TIGR03906" ]

[ "quinohemoprotein_amine_dehydro", "quino_hemo_SAM" ]

[ 414, 515 ]

2

[ "GP" ]

[ "GenProp0902" ]

[ "GP:GenProp0902" ]

1

[]

0

[ "PUB00055032" ]

[ "16546999" ]

[ "Involvement of a putative [Fe-S]-cluster-binding protein in the biogenesis of quinohemoprotein amine dehydrogenase." ]

[ 2006 ]

1

[ "IPR023867" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 508, 7 ]

2

[]

0

true

Family

Quinohemoprotein amine dehydrogenase, gamma subunit maturation protein

QH-AmDH_gsu_maturation

8

IPR023887

23,887

Quinohemoprotein amine dehydrogenase, alpha subunit

QH-AmDH_asu

Family

546

false

Quinohemoprotein amine dehydrogenases (QHNDH) ) are enzymes produced in the periplasmic space of certain Gram-negative bacteria, such as Paracoccus denitrificans and Pseudomonas putida, in response to primary amines, including n-butylamine and benzylamine. QHNDH catalyses the oxidative deamination of a wide range of al...

[]

0

[ "NCBIFAM" ]

[ "TIGR03908" ]

[ "QH_alpha" ]

[ 546 ]

1

[ "GP" ]

[ "GenProp0902" ]

[ "GP:GenProp0902" ]

1

[ "1jju", "1jmx", "1jmz", "1pby" ]

4

[ "PUB00013277", "PUB00022422", "PUB00035735", "PUB00035736", "PUB00035737" ]

[ "11704672", "12925784", "15234267", "12974623", "12427036" ]

[ "Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida. Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges.", "Structure of the phenylhydrazine adduct of the quinohemoprotein amine dehydrogenase from Paracoccus denitrificans at 1.7 A resolution.", ...

[ 2002, 2003, 2004, 2003, 2002 ]

5

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 535, 11 ]

2

[]

0

true

Family

Quinohemoprotein amine dehydrogenase, alpha subunit

QH-AmDH_asu

6

IPR023888

23,888

Sporulation delaying protein C-like

SdpC-like

Family

407

false

This entry represents the antimicrobial Sporulation delaying protein C from Bacillus subtilis (SdpC) and related proteins in species as distant as Myxococcus xanthus from the Deltaproteobacteria [ ]. SdpC collapses the proton motive force (probably both the membrane potential and pH gradient) across the cell membrane, ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF26137", "TIGR04032" ]

[ "Toxin_SdpC", "toxin_SdpC" ]

[ 407, 121 ]

2

[ "GP" ]

[ "GenProp0936" ]

[ "GP:GenProp0936" ]

1

[]

0

[ "PUB00055033", "PUB00055038", "PUB00106809", "PUB00106907", "PUB00161490" ]

[ "12817086", "16469701", "23687264", "22469514", "20805502" ]

[ "Cannibalism by sporulating bacteria.", "A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.", "Production of the cannibalism toxin SDP is a multistep process that requires SdpA and SdpB.", "The Bacillus subtilis cannibalism toxin SDP collapses the proton motive force and in...

[ 2003, 2006, 2013, 2012, 2010 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 384, 22, 1 ]

3

[]

0

true

Family

Sporulation delaying protein C-like

SdpC-like

1

IPR023889

23,889

TOMM system kinase/cyclase fusion protein

TOMM_kin_cyc

Family

256

false

This entry represents a family of proteins of around 1350 in length. They are found in multiple species of Burkholderia, in Acidovorax avenae subsp. citrulli AAC00-1 and Delftia acidovorans SPH-1, and in multiple copies in Sorangium cellulosum, in genomic neighbourhoods that include a cyclodehydratase/docking scaffold ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03903" ]

[ "TOMM_kin_cyc" ]

[ 256 ]

1

[ "GP" ]

[ "GenProp0901" ]

[ "GP:GenProp0901" ]

1

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "hydrothermal vent metagenome" ]

[ 254, 2 ]

2

[]

0

true

Family

TOMM system kinase/cyclase fusion protein

TOMM_kin_cyc

5

IPR023890

23,890

Pyrrolysine biosynthesis protein PylC

Pyrrolys_PylC

Family

144

false

This entry represents PylC, which is part of a three-gene cassette that directs the biosynthesis of pyrrolysine, the twenty-second amino acid, that is incorporated in some species at a UAG canonical stop codon [ ]. The radical S-adenosyl-L-methionine (SAM) protein PylB mediates a lysine mutase reaction that produces 3-...

[ "GO:0071524" ]

[ "pyrrolysine biosynthetic process" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR03909" ]

[ "pyrrolys_PylC" ]

[ 144 ]

1

[ "EC", "METACYC" ]

[ "6.3.2.59", "PWY-6994" ]

[ "EC:6.3.2.59", "METACYC:PWY-6994" ]

2

[ "4ffl", "4ffm", "4ffn", "4ffo", "4ffp", "4ffr" ]

6

[ "PUB00055034", "PUB00075348" ]

[ "17204561", "21455182" ]

[ "A natural genetic code expansion cassette enables transmissible biosynthesis and genetic encoding of pyrrolysine.", "The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine." ]

[ 2007, 2011 ]

2

[]

0

null

[ "Bacteria", "Methanobacteriati", "ecological metagenomes" ]

[ 72, 70, 2 ]

3

[]

0

true

Family

Pyrrolysine biosynthesis protein PylC

Pyrrolys_PylC

5

IPR023892

23,892

Cyclic nucleotide-binding domain protein

cNMP-bd

Family

119

false

Members of this protein family are uncharacterised and contain two copies of the cyclic nucleotide-binding domain. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. This suggests a poss...

[]

0

[ "NCBIFAM" ]

[ "TIGR03896" ]

[ "cyc_nuc_ocin" ]

[ 119 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 119 ]

1

[]

0

true

Family

Cyclic nucleotide-binding domain protein

cNMP-bd

4

IPR023893

23,893

His-Xaa-Ser system-associated, MauG-like protein

MauG-like

Family

47

false

This entry represents a protein family with homology to the MauG methylamine utilisation protein ( ). MauG is required to complete the maturation of the tryptophan tryptophylquinone (TTQ) cofactor in the methylamine dehydrogenase light (beta) chain. It occurs regularly with proteins of the His-Xaa-Ser system, which con...

[]

0

[ "NCBIFAM" ]

[ "TIGR03981" ]

[ "SAM_quin_mod" ]

[ 47 ]

1

[ "GP" ]

[ "GenProp0921" ]

[ "GP:GenProp0921" ]

1

[]

0

[ "PUB00055953" ]

[ "21478363" ]

[ "Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification." ]

[ 2011 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 47 ]

1

[]

0

true

Family

His-Xaa-Ser system-associated, MauG-like protein

MauG-like

6

IPR023894

23,894

Sporulation delaying protein SdpB

Sporulation_SdpB

Family

343

false

This entry represents SdpB, an integral membrane protein associated with production of the cannibalism peptide SdpC in Bacillus subtilis [ ], and related proteins. Similar proteins are found in Myxococcus xanthus.

[]

0

[ "NCBIFAM" ]

[ "TIGR04033" ]

[ "export_SdpB" ]

[ 343 ]

1

[ "GP" ]

[ "GenProp0936" ]

[ "GP:GenProp0936" ]

1

[]

0

[ "PUB00055033" ]

[ "12817086" ]

[ "Cannibalism by sporulating bacteria." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 341, 2 ]

2

[]

0

true

Family

Sporulation delaying protein SdpB

Sporulation_SdpB

1

IPR023895

23,895

Thiazolylpeptide-type bacteriocin precursor

Thiopep_bacteriocin_prcur

Family

478

false

Members of this protein family are the precursors of a family of small bacteriocins (i.e. microcins) with thiopeptide type modifications, a highly modified subclass of heterocycle-containing peptide antibiotics. Members tend to be found clustered in genomes with proteins recognised by and proteins/domains annotated as ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03892" ]

[ "thiopep_precurs" ]

[ 478 ]

1

[]

0

[]

0

[ "PUB00050356", "PUB00055035", "PUB00055036", "PUB00055037" ]

[ "18406324", "19196969", "19246004", "19265401" ]

[ "Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.", "Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.", "Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and c...

[ 2008, 2009, 2009, 2009 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 476, 2 ]

2

[]

0

true

Family

Thiazolylpeptide-type bacteriocin precursor

Thiopep_bacteriocin_prcur

7

IPR023896

23,896

D-alanyl-lipoteichoic acid biosynthesis DltD, Firmicutes

LTA_DltD

Family

2,448

false

DltD is part of the DltABCD system which is widely distributed in the Firmicutes for D-alanylation of lipoteichoic acids (LTA). The most common form of LTA, as in Staphylococcus aureus, has a backbone of polyglycerolphosphate [ ].

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF021438", "TIGR04092" ]

[ "DltD", "LTA_DltD" ]

[ 2107, 2448 ]

2

[ "GP", "GP" ]

[ "GenProp0958", "GenProp1398" ]

[ "GP:GenProp0958", "GP:GenProp1398" ]

2

[ "3bma", "6o93", "6pfx", "7dxm" ]

4

[ "PUB00055039" ]

[ "17434999" ]

[ "Functional analysis of D-alanylation of lipoteichoic acid in the probiotic strain Lactobacillus rhamnosus GG." ]

[ 2007 ]

1

[ "IPR006998" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 2444, 4 ]

2

[]

0

true

Family

D-alanyl-lipoteichoic acid biosynthesis DltD, Firmicutes

LTA_DltD

9

IPR023897

23,897

Spore photoproduct lyase, firmicutes

SPL_firmicutes

Family

1,534

false

This entry represents a family of Spore photoproduct lyase (SPL) proteins from firmicutes. Bacterial spores are remarkable in their resistance to chemical and physical stresses, including exposure to UV radiation. The unusual UV resistance of bacterial spores is a result of the unique photochemistry of spore DNA couple...

[ "GO:0003913" ]

[ "DNA photolyase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR04070" ]

[ "photo_TT_lyase" ]

[ 1534 ]

1

[ "EC" ]

[ "4.1.99.14" ]

[ "EC:4.1.99.14" ]

1

[ "4fhc", "4fhd", "4fhe", "4fhf", "4fhg", "4k9r", "4rh0", "4rh1" ]

8

[ "PUB00055040" ]

[ "19178276" ]

[ "Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct." ]

[ 2009 ]

1

[ "IPR049539" ]

[ "IPR034559", "IPR034560" ]

1

2

0

[ "Bacteria", "Methanosarcina", "Phytophthora kernoviae 00238/432", "ecological metagenomes" ]

[ 1525, 2, 1, 6 ]

4

[]

0

true

Family

Spore photoproduct lyase, firmicutes

SPL_firmicutes

6

IPR023898

23,898

Putative exported peptide YydF-like

YydF-like

Family

41

false

This entry describes a rare family of small proteins, about 50 residues in length, that includes YydF from Bacillus subtilis and SAG 2028 from Streptococcus agalactiae 2603V/R. Mutational analysis and genomic context show that members of this family likely are modified by a (variably present) radical SAM enzyme, are ex...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF27801", "TIGR04077" ]

[ "YydF", "expor_sig_YdyF" ]

[ 41, 33 ]

2

[ "GP" ]

[ "GenProp0955" ]

[ "GP:GenProp0955" ]

1

[]

0

[ "PUB00055041" ]

[ "17921301" ]

[ "The yydFGHIJ operon of Bacillus subtilis encodes a peptide that induces the LiaRS two-component system." ]

[ 2007 ]

1

[]

0

null

[ "Bacillati" ]

[ 41 ]

1

[]

0

true

Family

Putative exported peptide YydF-like

YydF-like

5

IPR023900

23,900

Nitrile hydratase alpha subunit /Thiocyanate hydrolase gamma subunit

CN_Hdrtase_asu/SCN_Hdrlase_gsu

Family

2,544

false

Nitrile hydratases ( ) are bacterial enzymes that catalyse the hydration of nitrile compounds to the corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as in environmental remediation for the removal of nitriles from waste streams. Nitrile...

[]

0

[ "PIRSF" ]

[ "PIRSF001426" ]

[ "NHase_alpha" ]

[ 2544 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "4.2.1.84", "PWY-5025", "PWY-581", "PWY-7308" ]

[ "EC:4.2.1.84", "METACYC:PWY-5025", "METACYC:PWY-581", "METACYC:PWY-7308" ]

4

[ "1ahj", "1ire", "1ugp", "1ugq", "1ugr", "1ugs", "1v29", "2ahj", "2cyz", "2cz0", "2cz1", "2cz6", "2cz7", "2d0q", "2dd4", "2dd5", "2dpp", "2dxb", "2dxc", "2qdy", "2zcf", "2zpb", "2zpe", "2zpf", "2zpg", "2zph", "2zpi", "2zzd", "3a8g", "3a8h", "3a8l", "3a8m"...

70

[ "PUB00006378", "PUB00019922", "PUB00031767", "PUB00035663", "PUB00044782", "PUB00044783" ]

[ "9195885", "9586994", "14717710", "17267045", "16417356", "9573140" ]

[ "Crystal structure of nitrile hydratase reveals a novel iron centre in a novel fold.", "Novel non-heme iron center of nitrile hydratase with a claw setting of oxygen atoms.", "Mutational and structural analysis of cobalt-containing nitrile hydratase on substrate and metal binding.", "Influence of cobalt subst...

[ 1997, 1998, 2004, 2007, 2006, 1998 ]

6

[]

[ "IPR023901" ]

0

1

0

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 2495, 8, 9, 32 ]

4

[]

0

true

Family

Nitrile hydratase alpha subunit /Thiocyanate hydrolase gamma subunit

CN_Hdrtase_asu/SCN_Hdrlase_gsu

3

IPR023901

23,901

Thiocyanate hydrolase, gamma subunit

Thiocyan_Hydrolase_gsu

Family

337

false

Members of this family are the gamma subunit of thiocyanate hydrolase. This family is closely related to the nitrile hydratase, alpha subunit ( ).

[]

0

[ "NCBIFAM" ]

[ "TIGR03887" ]

[ "thiocyan_alph" ]

[ 337 ]

1

[]

0

[ "2dd4", "2dd5", "2dxb", "2dxc", "2zzd", "3vyg" ]

6

[ "PUB00044782" ]

[ "16417356" ]

[ "Thiocyanate hydrolase is a cobalt-containing metalloenzyme with a cysteine-sulfinic acid ligand." ]

[ 2006 ]

1

[ "IPR023900" ]

[]

1

0

1

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 335, 2 ]

2

[]

0

true

Family

Thiocyanate hydrolase, gamma subunit

Thiocyan_Hydrolase_gsu

6

IPR023902

23,902

Sporulation delaying protein SdpA

Sporulation_SdpA

Family

372

false

This entry represents SdpA and similar proteins that are found in Myxococcus xanthus, Stigmatella aurantiaca DW4/3-1, Streptomyces sp. ACTE, etc. SdpA is associated with production and export of the cannibalism peptide SdpC in Bacillus subtilis [ ].

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF17418", "TIGR04034" ]

[ "SdpA", "export_SdpA" ]

[ 372, 325 ]

2

[ "GP" ]

[ "GenProp0936" ]

[ "GP:GenProp0936" ]

1

[]

0

[ "PUB00055033" ]

[ "12817086" ]

[ "Cannibalism by sporulating bacteria." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 370, 2 ]

2

[]

0

true

Family

Sporulation delaying protein SdpA

Sporulation_SdpA

4

IPR023903

23,903

Cyclised secreted peptide

Cyclised_pep

Family

20

false

Members of this family are short secreted precursor peptides, in which the mature form undergoes a cyclisation between a Lys and a Trp four residues away [ ]. The modification enzyme appears to be an adjacent encoded radical SAM protein. Genomes encoding this system include Streptococcus thermophilus LMD-9 and Lactococ...

[]

0

[ "NCBIFAM" ]

[ "TIGR04079" ]

[ "phero_cyc_pep" ]

[ 20 ]

1

[ "GP" ]

[ "GenProp0954" ]

[ "GP:GenProp0954" ]

1

[ "5v1t" ]

1

[ "PUB00055042" ]

[ "17921293" ]

[ "Control of the transcription of a short gene encoding a cyclic peptide in Streptococcus thermophilus: a new quorum-sensing system?" ]

[ 2007 ]

1

[]

0

null

[ "Bacteria" ]

[ 20 ]

1

[]

0

true

Family

Cyclised secreted peptide

Cyclised_pep

5

IPR023904

23,904

Peptide radical SAM maturase , YydG

Pep_rSAM_mat_YydG

Family

27

false

Members of this radical SAM protein family for peptide modification occur only in the context of members of family , which average about 50 amino acids in length. In Bacillus subtilis, this protein (YydG) appears to act on its cognate target peptide (YydF) prior to its export, and result in the creation of a signaling ...

[]

0

[ "NCBIFAM" ]

[ "TIGR04078" ]

[ "rSAM_yydG" ]

[ 27 ]

1

[ "GP" ]

[ "GenProp0955" ]

[ "GP:GenProp0955" ]

1

[ "8ai1", "8ai2", "8ai3", "8ai4", "8ai5", "8ai6" ]

6

[ "PUB00055041", "PUB00055953" ]

[ "17921301", "21478363" ]

[ "The yydFGHIJ operon of Bacillus subtilis encodes a peptide that induces the LiaRS two-component system.", "Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification." ]

[ 2007, 2011 ]

2

[]

0

null

[ "Bacilli" ]

[ 27 ]

1

[]

0

true

Family

Peptide radical SAM maturase , YydG

Pep_rSAM_mat_YydG

9

IPR023905

23,905

Acetyldiaminopimelate deacetylase

AcetylDAP_deacetylase

Family

2,180

false

Two lysine biosynthesis pathways evolved separately in organisms, the diaminopimelic acid (DAP) and aminoadipic acid (AAA) pathways. The DAP pathway synthesizes L-lysine from aspartate and pyruvate, and diaminopimelic acid is an intermediate. This pathway is utilised by most bacteria, some archaea, some fungi, some alg...

[ "GO:0050118", "GO:0009089" ]

[ "N-acetyldiaminopimelate deacetylase activity", "L-lysine biosynthetic process via diaminopimelate" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_01692" ]

[ "DapEL" ]

[ 2180 ]

1

[ "EC", "GP", "METACYC" ]

[ "3.5.1.47", "GenProp0787", "PWY-2941" ]

[ "EC:3.5.1.47", "GP:GenProp0787", "METACYC:PWY-2941" ]

3

[]

0

[ "PUB00055043" ]

[ "20418392" ]

[ "Methanococci use the diaminopimelate aminotransferase (DapL) pathway for lysine biosynthesis." ]

[ 2010 ]

1

[ "IPR017439" ]

[]

1

0

1

[ "Bacteria" ]

[ 2180 ]

1

[]

0

true

Family

Acetyldiaminopimelate deacetylase

AcetylDAP_deacetylase

5

IPR023906

23,906

Radical SAM target protein, putative

rSAM_target_put

Family

331

false

Members of this family of small proteins, approximately 100 amino acids in length, lack of homology to any known enzymes. Family members possess a distinctive C-terminal region motif, with the common modification target residue Cys flanked by sterically permissive Gly residues. They co-occur with a subfamily of radical...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF26005", "TIGR03995" ]

[ "rSAM_target_put", "target_X_rSAM" ]

[ 331, 325 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Halobacteria" ]

[ 65, 266 ]

2

[]

0

true

Family

Radical SAM target protein, putative

rSAM_target_put

6

IPR023907

23,907

Non-F420 flavinoid oxidoreductase

Non-F420_Flavin_OxRdtase

Family

1,378

false

This entry represents a family of oxidoreductases from species that lack F420 biosynthesis. It is suggested that members of this family bind FMN, FO, or a novel flavinoid cofactor, but not F420 per se.

[]

0

[ "NCBIFAM" ]

[ "TIGR03885" ]

[ "flavin_revert" ]

[ 1378 ]

1

[]

0

[]

0

[]

0

[ "IPR019945" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriota", "metagenomes" ]

[ 1326, 48, 4 ]

3

[]

0

true

Family

Non-F420 flavinoid oxidoreductase

Non-F420_Flavin_OxRdtase

6

IPR023909

23,909

F420-dependent oxidoreductase, NP1902A

F420_NP1902A

Family

282

false

This family of luciferase-like monooxygenases is restricted to the order Halobacteriales. SIMBAL analysis suggests this oxidoreductase binds coenzyme F420 rather than flavin mononucleotide [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR04024" ]

[ "F420_NP1902A" ]

[ 282 ]

1

[ "GP" ]

[ "GenProp0002" ]

[ "GP:GenProp0002" ]

1

[]

0

[ "PUB00055044" ]

[ "20675471" ]

[ "Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria." ]

[ 2010 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 282 ]

1

[]

0

true

Family

F420-dependent oxidoreductase, NP1902A

F420_NP1902A

2

IPR023910

23,910

Colanic acid biosynthesis, glycosyl transferase, WcaI

Colanic_acid_synth_WcaI

Family

997

false

This entry represents WcaI, one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR04007" ]

[ "wcaI" ]

[ 997 ]

1

[]

0

[]

0

[ "PUB00008202" ]

[ "8759852" ]

[ "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid." ]

[ 1996 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 997 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Colanic acid biosynthesis, glycosyl transferase, WcaI

Colanic_acid_synth_WcaI

7

IPR023911

23,911

MSMEG_0567/sll0787, C-terminal domain

MSMEG_0567/sll0787_C

Domain

441

false

This entry includes the C-terminal domain of MSMEG_0567 from Mycobacterium smegmatis. Members of this entry are found broadly in Cyanobacteria, Proteobacteria, Actinobacteria and has been linked to a nitrogen starvation response in some of those species.

[]

0

[ "NCBIFAM" ]

[ "TIGR04050" ]

[ "MSMEG_0567_Cter" ]

[ 441 ]

1

[ "GP" ]

[ "GenProp0939" ]

[ "GP:GenProp0939" ]

1

[]

0

[]

0

[]

0

null

[ "Actinomycetota", "freshwater metagenome" ]

[ 437, 4 ]

2

[]

0

true

Domain

MSMEG_0567/sll0787, C-terminal domain

MSMEG_0567/sll0787_C

9

IPR023912

23,912

Putative glycyl-radical enzyme activating enzyme YjjW

YjjW_bact

Family

1,651

false

Members of this family are radical SAM enzymes, designated YjjW in E. coli, that are paired with and appear to activate a glycyl radical enzyme of unknown function, designated YjjI. This activase and its target are found in Clostridial species as well as E. coli and cousins. Members of this family may be misannotated a...

[]

0

[ "SFLD", "NCBIFAM" ]

[ "SFLDF00392", "TIGR04041" ]

[ "YjjI_activase", "activase_YjjW" ]

[ 1570, 1645 ]

2

[ "GP" ]

[ "GenProp0938" ]

[ "GP:GenProp0938" ]

1

[]

0

[ "PUB00055953" ]

[ "21478363" ]

[ "Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification." ]

[ 2011 ]

1

[ "IPR040074" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1645, 2, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative glycyl-radical enzyme activating enzyme YjjW

YjjW_bact

4

IPR023913

23,913

Mycofactocin maturase MftC

MftC

Family

1,282

false

Mycofactocin maturase MftC is a radical S-adenosylmethionine (SAM) enzyme responsible for the first step of the biosynthesis of the enzyme cofactor mycofactocin (MFT). It catalyzes two reactions at the C terminus of the mycofactocin precursor (the MftA peptide): the first one is the oxidative decarboxylation of the C-t...

[]

0

[ "SFLD", "NCBIFAM" ]

[ "SFLDF00316", "TIGR03962" ]

[ "C-terminal_tyrosine_decarboxyl", "mycofact_rSAM" ]

[ 1246, 1282 ]

2

[ "EC", "EC", "GP", "METACYC" ]

[ "1.3.98.7", "4.1.99.26", "GenProp0917", "PWY-8122" ]

[ "EC:1.3.98.7", "EC:4.1.99.26", "GP:GenProp0917", "METACYC:PWY-8122" ]

4

[]

0

[ "PUB00096691", "PUB00096692", "PUB00096695" ]

[ "27312813", "31113891", "28634235" ]

[ "Mycofactocin biosynthesis: modification of the peptide MftA by the radical S-adenosylmethionine protein MftC.", "Mycofactocin Is Associated with Ethanol Metabolism in Mycobacteria.", "Mechanistic elucidation of the mycofactocin-biosynthetic radical S-adenosylmethionine protein, MftC." ]

[ 2016, 2019, 2017 ]

3

[ "IPR017200" ]

[]

1

0

1

[ "Bacteria", "Halobacteriales", "metagenomes" ]

[ 1236, 7, 39 ]

3

[]

0

true

Family

Mycofactocin maturase MftC

MftC

2

IPR023914

23,914

Pyrrolysine biosynthesis protein PylD

Pyrrolys_PylD

Family

139

false

This entry represents PylD, which is part of a three-gene cassette that directs the biosynthesis of pyrrolysine, the twenty-second amino acid, that is incorporated in some species at a UAG canonical stop codon [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR03911" ]

[ "pyrrolys_PylD" ]

[ 139 ]

1

[]

0

[ "4j43", "4j49", "4j4b", "4j4h", "4jk3", "4q39", "4q3a", "4q3b", "4q3c", "4q3d", "4q3e" ]

11

[ "PUB00055034" ]

[ "17204561" ]

[ "A natural genetic code expansion cassette enables transmissible biosynthesis and genetic encoding of pyrrolysine." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriati", "bioreactor metagenome" ]

[ 72, 66, 1 ]

3

[]

0

true

Family

Pyrrolysine biosynthesis protein PylD

Pyrrolys_PylD

1

IPR023915

23,915

UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, archaeal-type

Bifunctiontional_GlmU_arc-type

Family

1,089

false

The MJ_1101 protein from Methanococcus jannaschii has been characterised as the GlmU, a bifunctional enzyme (UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase) catalyzing the final two steps of UDP-GlcNAc biosynthesis. GlmU is responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, ...

[ "GO:0003977", "GO:0019134" ]

[ "UDP-N-acetylglucosamine diphosphorylase activity", "glucosamine-1-phosphate N-acetyltransferase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR03992" ]

[ "Arch_glmU" ]

[ 1089 ]

1

[ "EC", "EC", "METACYC" ]

[ "2.3.1.157", "2.7.7.23", "PWY-5514" ]

[ "EC:2.3.1.157", "EC:2.7.7.23", "METACYC:PWY-5514" ]

3

[ "2ggo", "2ggq", "5z09", "5z0a" ]

4

[ "PUB00054937", "PUB00093666" ]

[ "18263721", "15598657" ]

[ "Acetamido sugar biosynthesis in the Euryarchaea.", "Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7." ]

[ 2008, 2005 ]

2

[ "IPR050065" ]

[]

1

0

1

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 995, 64, 30 ]

3

[]

0

true

Family

UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, archaeal-type

Bifunctiontional_GlmU_arc-type

5

IPR023916

23,916

Colanic acid biosynthesis, glycosyl transferase, WcaC

Colanic_acid_synth_WcaC

Family

994

false

This is one of the glycosyl transferases involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR04015" ]

[ "WcaC" ]

[ 994 ]

1

[]

0

[]

0

[ "PUB00008202" ]

[ "8759852" ]

[ "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid." ]

[ 1996 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 994 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Colanic acid biosynthesis, glycosyl transferase, WcaC

Colanic_acid_synth_WcaC

5

IPR023917

23,917

UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, bacterial-type

Bifunctiontional_GlmU_bac-type

Family

2,439

false

The MJ_1101 protein from Methanococcus jannaschii has been characterised as the GlmU, a bifunctional enzyme (UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase) catalyzing the final two steps of UDP-GlcNAc biosynthesis [ ]. Homologues of this enzyme are identified in a number of bacteri...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF13562", "TIGR03991" ]

[ "NTP_transf_4", "alt_bact_glmU" ]

[ 2255, 2400 ]

2

[ "GP" ]

[ "GenProp0750" ]

[ "GP:GenProp0750" ]

1

[]

0

[ "PUB00034422", "PUB00054937" ]

[ "16930487", "18263721" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.", "Acetamido sugar biosynthesis in the Euryarchaea." ]

[ 2006, 2008 ]

2

[ "IPR050065" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Mollusca", "ecological metagenomes" ]

[ 21, 2362, 2, 54 ]

4

[]

0

true

Family

UDP-GlcNAc diphosphorylase/GlcNAc-1-P N-acetyltransferase, GlmU, bacterial-type

Bifunctiontional_GlmU_bac-type

2

IPR023918

23,918

Colanic acid biosynthesis, pyruvyl transferase, WcaK

Colanic_acid_synth_WcaK

Family

1,034

false

Pyruvyl transferase is involved in the biosynthesis of colanic acid, an exopolysaccharide expressed in Enterobacteraceae species [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR04006" ]

[ "wcaK" ]

[ 1034 ]

1

[]

0

[]

0

[ "PUB00008202" ]

[ "8759852" ]

[ "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid." ]

[ 1996 ]

1

[]

0

null

[ "Beauveria bassiana D1-5", "Gammaproteobacteria" ]

[ 1, 1033 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Colanic acid biosynthesis, pyruvyl transferase, WcaK

Colanic_acid_synth_WcaK

5

IPR023919

23,919

Nitrilase

Family

906

false

This family represents a subfamily of a C-N bond-cleaving hydrolases (see ) that includes nitrilase from Burkholderia phymatum. It catalyses the hydrolysis of a broad range of nitriles to yield their corresponding carboxylic acid and ammonia [ , ]. The preferred substrate is trans-cinnamonitrile, followed by mono/di-cy...

[]

0

[ "NCBIFAM" ]

[ "TIGR04048" ]

[ "nitrile_sll0784" ]

[ 906 ]

1

[ "GP" ]

[ "GenProp0939" ]

[ "GP:GenProp0939" ]

1

[ "3wuy" ]

1

[ "PUB00103888", "PUB00103889" ]

[ "34277586", "34270173" ]

[ "Purification and Characterization of Nit phym , a Robust Thermostable Nitrilase From Paraburkholderia phymatum.", "Nitrilase immobilization and transposition from a micro-scale batch to a continuous process increase the nicotinic acid productivity." ]

[ 2021, 2021 ]

2

[ "IPR044149" ]

[]

1

0

1

[ "Bacteria", "uncultured organism" ]

[ 885, 21 ]

2

[]

0

true

Family

Nitrilase

2

IPR023920

23,920

ABC transporter, substrate-binding protein, KPN01854

ABC_transptr_sub-bd_KPN01854

Family

840

false

ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found o...

[]

0

[ "NCBIFAM" ]

[ "TIGR04028" ]

[ "SBP_KPN_01854" ]

[ 840 ]

1

[ "GP" ]

[ "GenProp0935" ]

[ "GP:GenProp0935" ]

1

[]

0

[ "PUB00004290", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00025109", "PUB00026406", "PUB00043654" ]

[ "9872322", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "11080142", "11532960", "11421270" ]

[ "Crystal structure of the ATP-binding subunit of an ABC transporter.", "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC transporters: physiology, structure and mechanism--an overview.", "ABC transporters: from microorgani...

[ 1998, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2000, 2001, 2001 ]

11

[ "IPR030678" ]

[]

1

0

1

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 839, 1 ]

2

[]

0

true

Family

ABC transporter, substrate-binding protein, KPN01854

ABC_transptr_sub-bd_KPN01854

2

IPR023922

23,922

Sulphate-starvation-induced SfnB

S04_starv_induced_SfnB

Family

4,839

false

Members of this protein family belong to the greater family of acyl-CoA dehydrogenases. This family includes the sulphate starvation induced protein SfnB of Pseudomonas putida strain DS1, which is both encoded nearby to and phylogenetically closely correlated with the dimethyl sulphone monooxygenase SfnG. This family s...

[]

0

[ "NCBIFAM" ]

[ "TIGR04022" ]

[ "sulfur_SfnB" ]

[ 4839 ]

1

[ "GP" ]

[ "GenProp0934" ]

[ "GP:GenProp0934" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Neoptera", "metagenomes" ]

[ 4799, 2, 38 ]

3

[]

0

true

Family

Sulphate-starvation-induced SfnB

S04_starv_induced_SfnB

4

IPR023923

23,923

Alkylhydroperoxidase domain-containing protein, Avi7169

AhpD_Avi7169

Family

914

false

This entry represents alkylhydroperoxidase-related proteins. Most of these proteins contain the alkylhydroperoxidase core domain (AhpD).

[]

0

[ "NCBIFAM" ]

[ "TIGR04030" ]

[ "perox_Avi_7169" ]

[ 914 ]

1

[ "GP" ]

[ "GenProp0935" ]

[ "GP:GenProp0935" ]

1

[]

0

[]

0

[ "IPR010195" ]

[]

1

0

1

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 913, 1 ]

2

[]

0

true

Family

Alkylhydroperoxidase domain-containing protein, Avi7169

AhpD_Avi7169

3

IPR023927

23,927

2,3-diaminopropionate biosynthesis protein SbnA

SbnA

Family

2,328

false

Members of this family include SbnA, a protein of the staphyloferrin B biosynthesis operon of Staphylococcus aureus. SbnA and SbnB together appear to synthesize 2,3-diaminopropionate, a precursor of certain siderophores and other secondary metabolites. SbnA uses PLP and substrates O-phospho-L-serine and L-glutamate to ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03945" ]

[ "PLP_SbnA_fam" ]

[ 2328 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.5.1.140", "GenProp0908", "PWY-7694", "PWY-7706", "PWY-8008", "PWY-8381" ]

[ "EC:2.5.1.140", "GP:GenProp0908", "METACYC:PWY-7694", "METACYC:PWY-7706", "METACYC:PWY-8008", "METACYC:PWY-8381" ]

6

[ "5d84", "5d85", "5d86", "5d87" ]

4

[ "PUB00083270" ]

[ "24485762" ]

[ "Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor." ]

[ 2014 ]

1

[ "IPR050214" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 2322, 6 ]

2

[]

0

true

Family

2,3-diaminopropionate biosynthesis protein SbnA

SbnA

5

IPR023928

23,928

His-Xaa-Ser rich protein HxsA-like

HxsA-like

Family

341

false

Members of this uncharacterised protein family share a histidine/serine-rich cluster, typically H-R-S-H-S-S-H-R-S-H-S-S-H. Members are found always in the context of a pair of radical SAM proteins, HxsB and HxsC, and a fourth protein HxsD. The system is predicted to perform peptide modifications, likely in the His-Xaa-...

[]

0

[ "NCBIFAM" ]

[ "TIGR03979" ]

[ "His_Ser_Rich" ]

[ 341 ]

1

[ "GP" ]

[ "GenProp0921" ]

[ "GP:GenProp0921" ]

1

[]

0

[ "PUB00055953" ]

[ "21478363" ]

[ "Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification." ]

[ 2011 ]

1

[]

0

null

[ "Pseudomonadati", "bioreactor metagenome" ]

[ 340, 1 ]

2

[]

0

true

Family

His-Xaa-Ser rich protein HxsA-like

HxsA-like

4

IPR023930

23,930

Putative heme d1 biosynthesis protein, NirJ1

NirJ1

Family

190

false

Members of this radical SAM domain-containing family, designated NirJ1, occur in genomic contexts with a paralogue NirJ2, and with other nitrite reductase operon genes associated with heme d1 biosynthesis in Heliobacillus mobilis and Heliophilum fasciatum [ ]. NirJ1 is presumed to be a heme d1 biosynthesis protein by c...

[]

0

[ "NCBIFAM" ]

[ "TIGR04054" ]

[ "rSAM_NirJ1" ]

[ 190 ]

1

[]

0

[]

0

[ "PUB00055046" ]

[ "17906152" ]

[ "Insight into the haem d1 biosynthesis pathway in heliobacteria through bioinformatics analysis." ]

[ 2007 ]

1

[ "IPR034479" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 186, 4 ]

2

[]

0

true

Family

Putative heme d1 biosynthesis protein, NirJ1

NirJ1

6

IPR023931

23,931

Multidrug resistance protein MdtC

Multidrug-R_MdtC

Family

1,685

false

Multidrug resistance proteins are molecular pumps that participate in a low energy shock adaptive response in some bacteria. The MdtABC tripartite complex is composed of MdtA, MdtB and MdtC, and confers resistance against novobiocin and deoxycholate [ ]. The mdtABC operon is transcriptionally activated by BaeR and belo...

[]

0

[ "HAMAP" ]

[ "MF_01424" ]

[ "MdtC" ]

[ 1685 ]

1

[ "GP", "REACTOME" ]

[ "GenProp1199", "R-HSA-9638334" ]

[ "GP:GenProp1199", "REACTOME:R-HSA-9638334" ]

2

[]

0

[ "PUB00053915" ]

[ "12107134" ]

[ "The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate." ]

[ 2002 ]

1

[ "IPR001036" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta" ]

[ 1683, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Multidrug resistance protein MdtC

Multidrug-R_MdtC

6

IPR023932

23,932

CE1759 family FMN reductase

CE1759_FMN_reduct

Family

3,279

false

This entry represents a group of proteins that regularly co-occur in genomes, typically as gene pairs, with members of , a probable FMN-dependent member of the bacterial luciferase-like monooxygenase (LLM) family. At least one member, RF|YP_001509627.1 from Frankia sp. EAN1pec, is fused to the LLM protein. The function...

[]

0

[ "NCBIFAM" ]

[ "TIGR04037" ]

[ "LLM_duo_CE1759" ]

[ 3279 ]

1

[]

0

[ "3k1y", "3k20" ]

2

[]

0

[]

0

null

[ "Bacteria", "Rhynchospora breviuscula", "metagenomes" ]

[ 3273, 2, 4 ]

3

[]

0

true

Family

CE1759 family FMN reductase

CE1759_FMN_reduct

4

IPR023934

23,934

Luciferase-like monooxygenase, FMN-dependent, putative

LLM_FMN-dep_put

Family

3,665

false

This tightly conserved subfamily of the bacterial luciferase-like monooxygenase (LLM) family, with members showing more than 60 % pairwise sequence identity, includes proteins from both species with and without the ability to make coenzyme F420. Therefore, the likely cofactor is FMN rather than F420. The presence of th...

[]

0

[ "NCBIFAM" ]

[ "TIGR04036" ]

[ "LLM_CE1758_fam" ]

[ 3665 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3660, 5 ]

2

[]

0

true

Family

Luciferase-like monooxygenase, FMN-dependent, putative

LLM_FMN-dep_put

1

IPR023935

23,935

Replication factor C, large subunit

Rep_factor-C_lsu

Family

857

false

These proteins are part of the RFC clamp loader complex, which loads the PCNA sliding clamp onto DNA. The large subunits (RfcL) form a heteromultimer with small subunits (RfcS). Proteins in this entry belong to the activator 1 small subunit family RfcL subfamily.

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01508", "NF003229" ]

[ "RfcL", "PRK04195.1-5" ]

[ 818, 857 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "candidate division WOR-3 bacterium", "ecological metagenomes" ]

[ 841, 1, 15 ]

3

[]

0

true

Family

Replication factor C, large subunit

Rep_factor-C_lsu

1

IPR023936

23,936

Probable malonic semialdehyde reductase RutE-like

RutE-like

Family

4,260

false

This entry represents the putative NADH dehydrogenase/NAD(P)H nitroreductase RutE family. RutE appears to be a malonic semialdehyde reductase in the Rut pathway for pyrimidine degradation [ ].

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "CDD" ]

[ "MF_01204", "cd02148" ]

[ "Oxidoreductase_RutE_HadB", "RutE-like" ]

[ 2723, 4249 ]

2

[]

0

[]

0

[ "PUB00056792" ]

[ "20400551" ]

[ "The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Methanosarcinaceae", "leotiomyceta", "unclassified sequences" ]

[ 4200, 7, 3, 50 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Probable malonic semialdehyde reductase RutE-like

RutE-like

8

IPR023937

23,937

Bis(5'-nucleosyl)-tetraphosphatase PrpE

Bis(5'-nucleosyl)-tetraP_PrpE

Family

380

false

Bis(5'-nucleosyl)-tetraphosphatase (PrpE) asymmetrically hydrolyses Ap4p to yield AMP and ATP, but does not hydrolyse Ap2a or Ap6A. It also has an ATPase activity. In Bacillus subtilis, it has been shown to dephosphorylate phosphotyrosine but not phosphoserine or phosphothreonine from phosphorylated peptides [ ]. It is...

[ "GO:0004081", "GO:0016151" ]

[ "bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity", "nickel cation binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP" ]

[ "MF_01443" ]

[ "PrpE" ]

[ 380 ]

1

[ "EC" ]

[ "3.6.1.17" ]

[ "EC:3.6.1.17" ]

1

[]

0

[ "PUB00068779", "PUB00100526" ]

[ "12059787", "16740944" ]

[ "PrpE, a PPP protein phosphatase from Bacillus subtilis with unusual substrate specificity.", "Expression of genes coding for GerA and GerK spore germination receptors is dependent on the protein phosphatase PrpE." ]

[ 2002, 2006 ]

2

[]

0

null

[ "Bacillales" ]

[ 380 ]

1

[]

0

true

Family

Bis(5'-nucleosyl)-tetraphosphatase PrpE

Bis(5'-nucleosyl)-tetraP_PrpE

6

IPR023938

23,938

HMP-PP phosphatase

HMP-PP_phosphatase

Family

1,041

false

HMP-PP phosphatase catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) [ ].

[ "GO:0016818" ]

[ "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_01847" ]

[ "HMP_PP_phosphat" ]

[ 1041 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.6.1.-", "PWY-5757", "PWY-6147", "PWY-6383", "PWY-6797", "PWY-7206", "PWY-7419", "PWY-7539", "PWY-7719", "PWY-7821", "PWY-8289" ]

[ "EC:3.6.1.-", "METACYC:PWY-5757", "METACYC:PWY-6147", "METACYC:PWY-6383", "METACYC:PWY-6797", "METACYC:PWY-7206", "METACYC:PWY-7419", "METACYC:PWY-7539", "METACYC:PWY-7719", "METACYC:PWY-7821", "METACYC:PWY-8289" ]

11

[]

0

[ "PUB00053972" ]

[ "15292217" ]

[ "A genetic screen for the identification of thiamin metabolic genes." ]

[ 2004 ]

1

[ "IPR000150" ]

[]

1

0

1

[ "Beauveria bassiana D1-5", "Gammaproteobacteria" ]

[ 1, 1040 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

HMP-PP phosphatase

HMP-PP_phosphatase

2

IPR023940

23,940

Dihydrodipicolinate reductase

DHDPR_bac

Family

28,121

false

Dihydrodipicolinate reductase (DHDPR), a product of an essential gene referred to as dapB, catalyzes the second step of lysine biosynthesis [ , ]. It catalyses the reduction of 2,3-dihydrodipicolinate (DHDP) to 2,3,4,5-tetrahydrodipicolinate (THDP) in a nucleotide dependent reaction [ ]: 2,3-dihydrodipicolinate + NAD(P...

[ "GO:0008839", "GO:0009089" ]

[ "4-hydroxy-tetrahydrodipicolinate reductase activity", "L-lysine biosynthetic process via diaminopimelate" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00102", "PIRSF000161", "PTHR20836", "TIGR00036" ]

[ "DapB", "DHPR", "", "dapB" ]

[ 23334, 26265, 28091, 25573 ]

4

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC" ]

[ "1.17.1.8", "GenProp0125", "GenProp0788", "PWY-2941", "PWY-2942", "PWY-5097" ]

[ "EC:1.17.1.8", "GP:GenProp0125", "GP:GenProp0788", "METACYC:PWY-2941", "METACYC:PWY-2942", "METACYC:PWY-5097" ]

6

[ "1arz", "1c3v", "1dih", "1dru", "1drv", "1drw", "1p9l", "1vm6", "1yl5", "1yl6", "1yl7", "3ijp", "3qy9", "4f3y", "4ywj", "5eer", "5ees", "5kt0", "5tej", "5tek", "5tem", "5ten", "5tjy", "5tjz", "5u5i", "5u5n", "5ua0", "5ugj", "5ugv", "5us6", "5wol", "5z2d"...

37

[ "PUB00000417", "PUB00023845", "PUB00028085", "PUB00065503", "PUB00072990", "PUB00074043" ]

[ "7893645", "12962488", "8993314", "21803042", "20503968", "23722845" ]

[ "Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.", "The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity.", "Reaction mechanis...

[ 1995, 2003, 1997, 2011, 2010, 2013 ]

6

[]

[ "IPR011859" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Megaviridae environmental sample", "unclassified sequences" ]

[ 597, 25016, 1912, 1, 595 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 1, 12, 21 ]

4

true

Family

Dihydrodipicolinate reductase

DHDPR_bac

5

IPR023941

23,941

Glutathione-regulated potassium-efflux system protein KefC

K_H_efflux_KefC

Family

1,218

false

The kefC gene encodes a potassium-efflux system that is regulated by glutathione metabolites [ , , ]. Full activation of KefC also requires a soluble regulatory protein, KefF [ , ]. KefC belongs to the monovalent cation:proton antiporter 2(CPA2) transporter family TC 2.A.37 (http://www.tcdb.org/search/result.php?tc=2.A...

[ "GO:0015503", "GO:0015643", "GO:0019899", "GO:0006813", "GO:0051595", "GO:0005886" ]

[ "glutathione-regulated potassium exporter activity", "toxic substance binding", "enzyme binding", "potassium ion transport", "response to methylglyoxal", "plasma membrane" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]

6

[ "HAMAP" ]

[ "MF_01413" ]

[ "K_H_efflux_KefC" ]

[ 1218 ]

1

[ "GP" ]

[ "GenProp1160" ]

[ "GP:GenProp1160" ]

1

[]

0

[ "PUB00003817", "PUB00053157", "PUB00055099", "PUB00061650", "PUB00061651" ]

[ "2046548", "11053405", "8594323", "9312097", "21742892" ]

[ "The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli.", "Identification of an ancillary protein, YabF, required for activity of the KefC glutathione-gated potassium efflux system in Escherichia coli.", "Potassium channel activation by glutathio...

[ 1991, 2000, 1995, 1997, 2011 ]

5

[ "IPR006036" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 1218 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glutathione-regulated potassium-efflux system protein KefC

K_H_efflux_KefC

4

IPR023942

23,942

3-keto-L-gulonate-6-phosphate decarboxylase, UlaD

3-keto-L-gulonate6Pdecase_UlaD

Family

449

false

3-keto-L-gulonate 6-phosphate decarboxylase (KGPDC) ( ) is encoded by the ulaD gene in Escherichia coli [ ]. The enzyme catalyses the decarboxylation of 3-keto-L-gulonate-6-phosphate into L-xylulose-5-phosphate, and may be involved in anaerobic L-ascorbate utilisation [ ]. KGPDC is a homodimer of (β/α)8-barrels, with t...

[ "GO:0000287", "GO:0033982", "GO:0019854" ]

[ "magnesium ion binding", "3-dehydro-L-gulonate-6-phosphate decarboxylase activity", "L-ascorbic acid catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_01267" ]

[ "UlaD" ]

[ 449 ]

1

[ "EC", "METACYC" ]

[ "4.1.1.85", "PWY-6961" ]

[ "EC:4.1.1.85", "METACYC:PWY-6961" ]

2

[ "1kv8", "1kw1", "1q6l", "1q6o", "1q6q", "1q6r", "1so3", "1so4", "1so5", "1so6", "1xbv", "1xbx", "1xby", "1xbz" ]

14

[ "PUB00009905", "PUB00026830" ]

[ "11741871", "11900527" ]

[ "Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons.", "Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Enterobacteriaceae" ]

[ 449 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

3-keto-L-gulonate-6-phosphate decarboxylase, UlaD

3-keto-L-gulonate6Pdecase_UlaD

8

IPR023943

23,943

Enolase-phosphatase E1

Enolase-ppase_E1

Family

6,895

false

This enzyme is the enolase-phosphatase of methionine salvage, a pathway that regenerates methionine from methylthioadenosine (MTA). Adenosylmethionine (AdoMet) is a donor of different moieties for various processes, including methylation reactions. Use of AdoMet for spermidine biosynthesis, which leads to polyamine bio...

[ "GO:0000287", "GO:0043874", "GO:0019509" ]

[ "magnesium ion binding", "acireductone synthase activity", "L-methionine salvage from methylthioadenosine" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "SFLD", "NCBIFAM", "CDD" ]

[ "MF_01681", "SFLDF00044", "TIGR01691", "cd01629" ]

[ "Salvage_MtnC", "enolase-phosphatase", "enolase-ppase", "HAD_EP" ]

[ 4084, 4426, 6882, 6127 ]

4

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.77", "GenProp0729", "R-BTA-1237112", "R-CEL-1237112", "R-DDI-1237112", "R-DME-1237112", "R-DRE-1237112", "R-HSA-1237112", "R-MMU-1237112", "R-RNO-1237112", "R-SCE-1237112", "R-SPO-1237112", "R-XTR-1237112" ]

[ "EC:3.1.3.77", "GP:GenProp0729", "REACTOME:R-BTA-1237112", "REACTOME:R-CEL-1237112", "REACTOME:R-DDI-1237112", "REACTOME:R-DME-1237112", "REACTOME:R-DRE-1237112", "REACTOME:R-HSA-1237112", "REACTOME:R-MMU-1237112", "REACTOME:R-RNO-1237112", "REACTOME:R-SCE-1237112", "REACTOME:R-SPO-1237112", ...

13

[ "1yns", "1zs9", "2g80" ]

3

[]

0

[]

[ "IPR027511" ]

0

1

0

[ "Bacteria", "Eukaryota", "Thermoplasmatales", "ecological metagenomes" ]

[ 3024, 3857, 2, 12 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 2, 2, 3, 1, 1, 6, 5, 1, 1, 13 ]

12

true

Family

Enolase-phosphatase E1

Enolase-ppase_E1

7

IPR023944

23,944

Anaerobic nitric oxide reductase transcription regulator

NorR

Family

1,049

false

These proteins are required for the expression of anaerobic nitric oxide(NO) reductase. They acts as transcriptional activators for at least the norVW operon. NorR requires activation by sigma-54 [ , ].

[ "GO:0003700", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_01314" ]

[ "NorR" ]

[ 1049 ]

1

[]

0

[]

0

[ "PUB00055056", "PUB00055092" ]

[ "11751865", "12586421" ]

[ "Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli.", "Regulation of the flavorubredoxin nitric oxide reductase gene in Escherichia coli: nitrate repression, nitrite induction, and possible post-transcription control." ]

[ 2002, 2003 ]

2

[]

0

null

[ "Bacteria" ]

[ 1049 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Anaerobic nitric oxide reductase transcription regulator

NorR

6

IPR023945

23,945

N-acetylmannosamine kinase, bacterial

ManNAc_kinase_bac

Family

945

false

A family of bacterial proteins has been described which groups transcriptional repressors, sugar kinases and yet uncharacterised open reading frames [ ]. This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylos...

[ "GO:0005524", "GO:0008270", "GO:0009384", "GO:0019262" ]

[ "ATP binding", "zinc ion binding", "N-acylmannosamine kinase activity", "N-acetylneuraminate catabolic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "HAMAP" ]

[ "MF_01234" ]

[ "ManNAc_kinase" ]

[ 945 ]

1

[ "EC", "METACYC" ]

[ "2.7.1.60", "PWY-6138" ]

[ "EC:2.7.1.60", "METACYC:PWY-6138" ]

2

[ "2aa4", "6jda", "6jdb", "6jdc", "6jdh", "6jdo" ]

6

[ "PUB00003590", "PUB00019912", "PUB00054267", "PUB00055049" ]

[ "7952186", "9864311", "15157072", "17979299" ]

[ "Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria.", "Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli.", "Identifying latent enzyme activities: substrate ambiguity within ...

[ 1994, 1999, 2004, 2007 ]

4

[ "IPR000600" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 945 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

N-acetylmannosamine kinase, bacterial

ManNAc_kinase_bac

1

IPR023946

23,946

Endo-type membrane-bound lytic murein transglycosylase A

EmtA

Family

813

false

This murein-degrading enzyme may play a role in the recycling of muropeptides during cell elongation and/or cell division. It catalsyses the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formatio...

[ "GO:0008932", "GO:0016837", "GO:0016998", "GO:0009279" ]

[ "lytic endotransglycosylase activity", "carbon-oxygen lyase activity, acting on polysaccharides", "cell wall macromolecule catabolic process", "cell outer membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "HAMAP", "NCBIFAM" ]

[ "MF_01381", "NF012014" ]

[ "EmtA", "PRK15470.1" ]

[ 679, 813 ]

2

[]

0

[ "2y8p", "3t36", "4hjv", "4hjy", "4hjz", "6ghy", "6ghz", "6gi3", "6gi4" ]

9

[ "PUB00055096" ]

[ "9642199" ]

[ "Membrane-bound lytic endotransglycosylase in Escherichia coli." ]

[ 1998 ]

1

[]

0

null

[ "Gammaproteobacteria", "Peronospora farinosa", "human gut metagenome" ]

[ 811, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Endo-type membrane-bound lytic murein transglycosylase A

EmtA

2

IPR023947

23,947

Glutathione-regulated potassium-efflux system ancillary protein KefG

K_H_efflux_KefG

Family

1,511

false

KefG is required for full activity of KefB. It is unlikely that KefG has oxido-reductase activity, it has probably evolved from its function as an oxido-reductase to be a regulator of KefB. KefG belongs to the NAD(P)H dehydrogenase (quinone) family,(KefG subfamily).

[ "GO:0006813" ]

[ "potassium ion transport" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_01415", "NF003430" ]

[ "K_H_efflux_KefG", "PRK04930.1" ]

[ 1370, 1510 ]

2

[ "EC", "GP", "METACYC", "METACYC" ]

[ "1.6.5.2", "GenProp1131", "PWY-7731", "PWY-7999" ]

[ "EC:1.6.5.2", "GP:GenProp1131", "METACYC:PWY-7731", "METACYC:PWY-7999" ]

4

[]

0

[]

0

[ "IPR046980" ]

[]

1

0

1

[ "Bacteria", "human gut metagenome" ]

[ 1510, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glutathione-regulated potassium-efflux system ancillary protein KefG

K_H_efflux_KefG

3

IPR023949

23,949

RNA polymerase-associated protein RapA

Helicase_RapA

Family

4,564

false

RNA polymerase-associated protein RapA is a transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling [ ]. This stimulation occurs in cases of stress conditions such as supercoiled DNA or high salt concentrations. The protein probably acts by releasing the RNAP, when it is trap...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "HAMAP" ]

[ "MF_01821" ]

[ "Helicase_RapA" ]

[ 4564 ]

1

[ "EC", "METACYC" ]

[ "3.6.4.-", "PWY-7250" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250" ]

2

[ "4s20", "6bog", "7m8e", "7mkn", "7mkq", "8so8", "8sp4", "8spg", "8t0l" ]

9

[ "PUB00055098" ]

[ "11751638" ]

[ "RapA, a bacterial homolog of SWI2/SNF2, stimulates RNA polymerase recycling in transcription." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Trichuris trichiura", "metagenomes" ]

[ 4534, 1, 29 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RNA polymerase-associated protein RapA

Helicase_RapA

6

IPR023950

23,950

Flavohemoprotein

Hmp

Family

3,870

false

This entry represents flavohemoproteins, which have multiple enzymatic activities and consist of three distinct domains - an N-terminal heme- and oxygen-binding domain (globin domain) followed by an oxidoreductase FAD-binding domain and a NAD-binding reductase domain [ , ]. They function as nitric oxide dioxygenases [ ...

[ "GO:0008941", "GO:0019825", "GO:0020037", "GO:0071949", "GO:0051409" ]

[ "nitric oxide dioxygenase NAD(P)H activity", "oxygen binding", "heme binding", "FAD binding", "response to nitrosative stress" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

5

[ "HAMAP" ]

[ "MF_01252" ]

[ "Hmp" ]

[ 3870 ]

1

[ "EC" ]

[ "1.14.12.17" ]

[ "EC:1.14.12.17" ]

1

[ "1cqx", "1gvh", "3ozu", "3ozv", "3ozw" ]

5

[ "PUB00036827", "PUB00055050", "PUB00055051", "PUB00055052", "PUB00055053", "PUB00055054", "PUB00055770", "PUB00075069" ]

[ "11964402", "10777548", "9724711", "1601132", "8022841", "11751864", "21210640", "10922365" ]

[ "The X-ray structure of ferric Escherichia coli flavohemoglobin reveals an unexpected geometry of the distal heme pocket.", "Steady-state and transient kinetics of Escherichia coli nitric-oxide dioxygenase (flavohemoglobin). The B10 tyrosine hydroxyl is essential for dioxygen binding and catalysis.", "Nitric ox...

[ 2002, 2000, 1998, 1992, 1994, 2002, 2011, 2000 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3774, 93, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flavohemoprotein

Hmp

3

IPR023951

23,951

L-ascorbate-6-phosphate lactonase UlaG

L-ascorbate_6P_UlaG

Family

438

false

These proteins catalyse the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P, which is essential for L-ascorbate utilization under anaerobic conditions [ , ]. UlaG is a manganese-dependent l-ascorbate-6-P lactonase that catalyses the hydrolysis of L-ascorbate-6-phosphate to 3-keto-L-gulonate-6-phosphate superfa...

[ "GO:0030145", "GO:0035460", "GO:0019854" ]

[ "manganese ion binding", "L-ascorbate 6-phosphate lactonase activity", "L-ascorbic acid catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_01266" ]

[ "UlaG" ]

[ 438 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.1.-", "PWY-1921", "PWY-5835", "PWY-6190", "PWY-6308", "PWY-6322", "PWY-6339", "PWY-6415", "PWY-6558", "PWY-6848", "PWY-7002", "PWY-7352", "PWY-7367", "PWY-7521", "PWY-7599", "PWY-7660", "PWY-7712", "PWY-7713", "PWY-7730", "PWY-7769", "PWY-7982", "PWY-8058", "PWY-8143...

[ "EC:3.1.1.-", "METACYC:PWY-1921", "METACYC:PWY-5835", "METACYC:PWY-6190", "METACYC:PWY-6308", "METACYC:PWY-6322", "METACYC:PWY-6339", "METACYC:PWY-6415", "METACYC:PWY-6558", "METACYC:PWY-6848", "METACYC:PWY-7002", "METACYC:PWY-7352", "METACYC:PWY-7367", "METACYC:PWY-7521", "METACYC:PWY-7...

28

[ "2wyl", "2wym" ]

2

[ "PUB00054948", "PUB00055105", "PUB00087024", "PUB00151248", "PUB00151249" ]

[ "12644495", "20359483", "17597585", "33514861", "21943130" ]

[ "The ascorbate transporter of Escherichia coli.", "Molecular architecture of the Mn2+-dependent lactonase UlaG reveals an RNase-like metallo-beta-lactamase fold and a novel quaternary structure.", "Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their s...

[ 2003, 2010, 2007, 2021, 2011 ]

5

[]

0

null

[ "Enterobacteriaceae" ]

[ 438 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

L-ascorbate-6-phosphate lactonase UlaG

L-ascorbate_6P_UlaG

5

IPR023952

23,952

Inosose dehydratase

IolE

Family

1,290

false

This enzyme catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol) [ ]. It uses glutathione and cobalt or manganese as cofactors and belongs to the iolE/mocC family.

[ "GO:0030145", "GO:0050114", "GO:0019310" ]

[ "manganese ion binding", "myo-inosose-2 dehydratase activity", "inositol catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_01672" ]

[ "IolE" ]

[ 1290 ]

1

[ "EC" ]

[ "4.2.1.44" ]

[ "EC:4.2.1.44" ]

1

[ "3cny" ]

1

[ "PUB00055102" ]

[ "14993306" ]

[ "The fifth gene of the iol operon of Bacillus subtilis, iolE, encodes 2-keto-myo-inositol dehydratase." ]

[ 2004 ]

1

[ "IPR030823" ]

[]

1

0

1

[ "Bacteria", "bioreactor metagenome" ]

[ 1288, 2 ]

2

[]

0

true

Family

Inosose dehydratase

IolE

6

IPR023953

23,953

Heme oxygenase IsdG

IsdG

Family

285

false

IsdG is a heme-degrading components of the Isd system in Gram-positive bacteria such as S. aureus [ ]. It may function as a heme-degrading monooxygenase [ ]. It allows pathogenic bacteria to utilise host heme as an iron source and enables the release of free iron through catalysis of oxidative degradation of the heme m...

[ "GO:0004392", "GO:0033212" ]

[ "heme oxygenase (decyclizing) activity", "iron import into cell" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_01272" ]

[ "Heme_degrading_monooxygenase" ]

[ 285 ]

1

[]

0

[ "1sqe", "1xbw", "2zdo", "2zdp", "3lgm", "3lgn", "3qgp", "4fnh", "4fni", "8avh", "8avi" ]

11

[ "PUB00055055", "PUB00074090" ]

[ "16428411", "19853304" ]

[ "Bacillus anthracis IsdG, a heme-degrading monooxygenase.", "Structural biology of heme binding in the Staphylococcus aureus Isd system." ]

[ 2006, 2010 ]

2

[]

0

null

[ "Bacillota", "human gut metagenome" ]

[ 284, 1 ]

2

[]

0

true

Family

Heme oxygenase IsdG

IsdG

5

IPR023954

23,954

C4-dicarboxylate transport protein

C4_dicarb_transport

Family

5,152

false

It has been shown [ ] that integral membrane proteins that mediate the uptake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. One of these families [ ] is known as the s...

[ "GO:0015293", "GO:0006835", "GO:0016020" ]

[ "symporter activity", "dicarboxylic acid transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP" ]

[ "MF_01300" ]

[ "C4_dicarb_transport" ]

[ 5152 ]

1

[]

0

[]

0

[ "PUB00000660", "PUB00004137", "PUB00004138", "PUB00004767", "PUB00055091" ]

[ "8031825", "1448170", "1280334", "1279699", "17088549" ]

[ "A functional superfamily of sodium/solute symporters.", "Cloning and expression of a rat brain L-glutamate transporter.", "Primary structure and functional characterization of a high-affinity glutamate transporter.", "Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate tra...

[ 1994, 1992, 1992, 1992, 2006 ]

5

[ "IPR001991" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5138, 4, 10 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

C4-dicarboxylate transport protein

C4_dicarb_transport

7

IPR023955

23,955

D-tagatose-bisphosphate aldolase, class II, subunit GatY

TagBP_aldolase_GatY

Family

563

false

Escherichia coli and other enteric bacteria contain two closely related D-tagatose 1,6-bisphosphate (TagBP)-specific aldolases - KbaYZ (also known as AgaYZ) and GatYZ. Unlike other class II aldolases, which are homodimeric enzymes, KbaYZ and GatYZ are heterodimers, and are comprised of subunits KbaY/GatY and GatY/GatZ....

[ "GO:0009025", "GO:0019404", "GO:2001059" ]

[ "tagatose-bisphosphate aldolase activity", "galactitol catabolic process", "D-tagatose 6-phosphate catabolic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP" ]

[ "MF_01294" ]

[ "TagBP_aldolase_GatY" ]

[ 563 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "4.1.2.40", "PWY-7077", "PWY-7395", "PWY-8324" ]

[ "EC:4.1.2.40", "METACYC:PWY-7077", "METACYC:PWY-7395", "METACYC:PWY-8324" ]

4

[]

0

[ "PUB00014683", "PUB00014684" ]

[ "11976750", "8955298" ]

[ "Two class II D-tagatose-bisphosphate aldolases from enteric bacteria.", "Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism." ]

[ 2002, 1996 ]

2

[]

0

null

[ "Enterobacteriaceae", "Trichuris trichiura" ]

[ 562, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

D-tagatose-bisphosphate aldolase, class II, subunit GatY

TagBP_aldolase_GatY

1

IPR023956

23,956

Acireductone dioxygenase ARD, bacteria

ARD_bac

Family

4,214

false

Acireductone dioxygenase catalyses 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene), depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD or ARD') produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alph...

[ "GO:0005506", "GO:0010308", "GO:0010309", "GO:0016151", "GO:0019284" ]

[ "iron ion binding", "acireductone dioxygenase (Ni2+-requiring) activity", "acireductone dioxygenase [iron(II)-requiring] activity", "nickel cation binding", "L-methionine salvage from S-adenosylmethionine" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

5

[ "HAMAP" ]

[ "MF_01682" ]

[ "Salvage_MtnD" ]

[ 4214 ]

1

[ "EC", "EC", "METACYC", "METACYC" ]

[ "1.13.11.53", "1.13.11.54", "PWY-4361", "PWY-5389" ]

[ "EC:1.13.11.53", "EC:1.13.11.54", "METACYC:PWY-4361", "METACYC:PWY-5389" ]

4

[ "1zrr", "2hji", "4qgl", "4qgm" ]

4

[ "PUB00075693" ]

[ "8407993" ]

[ "A bacterial enzyme that catalyzes formation of carbon monoxide." ]

[ 1993 ]

1

[ "IPR004313" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Thermoplasmatales", "ecological metagenomes" ]

[ 4191, 7, 2, 14 ]

4

[]

0

true

Family

Acireductone dioxygenase ARD, bacteria

ARD_bac

8

IPR023957

23,957

Anaerobic nitric oxide reductase flavorubredoxin

Anaer_NO_rdtase_flvorubredoxin

Family

1,399

false

This entry represents an anaerobic nitric oxide reductase, which utilises NADH to detoxify nitric oxide and therefore protects 4Fe-4S NO-sensitive enzymes [ , ].

[ "GO:0005506", "GO:0016966" ]

[ "iron ion binding", "nitric oxide reductase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP" ]

[ "MF_01312" ]

[ "NorV" ]

[ 1399 ]

1

[]

0

[ "4d02", "5lld", "5lmc", "6etb", "7r0f", "7r1h", "7r1j", "7r2o", "7r2p", "7r2r", "7r2s" ]

11

[ "PUB00055056", "PUB00055057" ]

[ "11751865", "12101220" ]

[ "Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli.", "A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin." ]

[ 2002, 2002 ]

2

[ "IPR016440" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta" ]

[ 1397, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Anaerobic nitric oxide reductase flavorubredoxin

Anaer_NO_rdtase_flvorubredoxin

1

IPR023958

23,958

Malate dehydrogenase, type 1, bacterial

Malate_DH_type1_bac

Family

2,221

false

This enzyme catalyzes the reversible oxidation of malate to oxaloacetate. It exist as a homodimer and belongs to the LDH/MDH superfamily, specifically to the MDH type 1 family.

[ "GO:0030060", "GO:0006099" ]

[ "L-malate dehydrogenase (NAD+) activity", "tricarboxylic acid cycle" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_01516" ]

[ "Malate_dehydrog_1" ]

[ 2221 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.1.1.37", "PWY-1622", "PWY-5392", "PWY-561", "PWY-5690", "PWY-6728", "PWY-6969", "PWY-7115", "PWY-7383", "PWY-8086" ]

[ "EC:1.1.1.37", "METACYC:PWY-1622", "METACYC:PWY-5392", "METACYC:PWY-561", "METACYC:PWY-5690", "METACYC:PWY-6728", "METACYC:PWY-6969", "METACYC:PWY-7115", "METACYC:PWY-7383", "METACYC:PWY-8086" ]

10

[ "1emd", "1ib6", "1ie3", "2cmd", "2pwz", "3hhp", "4e0b", "5kka", "5z3w", "6aoo", "6bal", "6itl", "6ka0", "6ka1", "7cgc", "7cgd", "7xqn", "9wxs" ]

18

[]

0

[ "IPR010097" ]

[]

1

0

1

[ "Bacteria", "marine metagenome" ]

[ 2220, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Malate dehydrogenase, type 1, bacterial

Malate_DH_type1_bac

7

IPR023959

23,959

Lipoprotein LpqB

LpqB

Family

1,410

false

LpqB may modulate activity of the MtrAB system in controlling homeostasis of the cell wall and cell division. It partially restores antibiotic resistance to M.smegmatis in which this gene has been disrupted [ ].

[]

0

[ "HAMAP" ]

[ "MF_01373" ]

[ "LpqB_lipoprot" ]

[ 1410 ]

1

[]

0

[]

0

[ "PUB00104902" ]

[ "20233304" ]

[ "A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium." ]

[ 2010 ]

1

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 1409, 1 ]

2

[]

0

true

Family

Lipoprotein LpqB

LpqB

4

IPR023960

23,960

Cytochrome b6-f complex iron-sulfur subunit

Cyt_b6_f_Rieske

Family

1,043

false

This entry represents the Rieske FeS protein (encoded by the PetC gene) of the cytochrome b6f complex from plants and cyanobacteria. The Rieske subunit acts by binding plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to the cytochrome f haem iron. The 2Fe-2S cluster is bou...

[ "GO:0051537", "GO:0016020" ]

[ "2 iron, 2 sulfur cluster binding", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP" ]

[ "MF_01335" ]

[ "Cytb6_f_Rieske" ]

[ 1043 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "7.1.1.6", "PWY-101", "PWY-8270", "PWY-8271" ]

[ "EC:7.1.1.6", "METACYC:PWY-101", "METACYC:PWY-8270", "METACYC:PWY-8271" ]

4

[ "1vf5", "2d2c", "2e74", "2e75", "2e76", "2zt9", "4h0l", "4h13", "4h44", "4i7z", "4ogq", "4pv1", "6rqf", "7qrm", "7r0w", "7zxy", "7zyv", "9es7", "9es8", "9es9" ]

20

[ "PUB00032072", "PUB00093899", "PUB00093900" ]

[ "14526088", "12970486", "28754840" ]

[ "Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity.", "Knock-out of the genes coding for the Rieske protein and the ATP-synthase delta-subunit of Arabidopsis. Effects on photosynthesis, thylakoid protein composition, and nuclear chloroplast gene expression.", "Overexpression ...

[ 2003, 2003, 2017 ]

3

[ "IPR014349" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 427, 615, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 7 ]

3

true

Family

Cytochrome b6-f complex iron-sulfur subunit

Cyt_b6_f_Rieske

8