interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR024077 | 24,077 | Neurolysin/Thimet oligopeptidase, domain 2 | Neurolysin/TOP_dom2 | Homologous_superfamily | 35,144 | false | false | Thimet oligopeptidase and neurolysin are closely related zinc-dependent metallopeptidases that metabolize small bioactive peptides. They cleave many substrates at the same sites, but they recognise different positions on others [ ]. This entry represents an α orthogonal bundle domain found in these and related peptidas... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.1370.10"
] | [
""
] | [
35144
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.24",
"3.4.24.59",
"R-DDI-983168",
"R-HSA-375276",
"R-HSA-983168",
"R-MMU-375276",
"R-MMU-983168",
"R-RNO-375276",
"R-RNO-983168",
"R-SCE-983168",
"R-SSC-375276"
] | [
"EC:3.4.24",
"EC:3.4.24.59",
"REACTOME:R-DDI-983168",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-983168",
"REACTOME:R-SCE-983168",
"REACTOME:R-SSC-375276"
] | 11 | [
"1i1i",
"1s4b",
"1y79",
"2o36",
"2o3e",
"4fxy",
"5luz",
"5lv0",
"8vju",
"8vjv",
"8vjw",
"8vjx",
"8vjy"
] | 13 | [
"PUB00042098"
] | [
"17251185"
] | [
"Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobiales",
"Viruses",
"unclassified sequences"
] | [
19941,
14868,
18,
18,
299
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
12,
3,
11,
3,
2,
15,
10,
2,
8,
19,
2,
1,
21
] | 13 | true | Homologous_superfamily | Neurolysin/Thimet oligopeptidase, domain 2 | Neurolysin/Thimet oligopeptidase, domain 2 | Neurolysin/TOP_dom2 | 2 |
IPR024078 | 24,078 | Putative deacetylase LmbE-like domain superfamily | LmbE-like_dom_sf | Homologous_superfamily | 50,378 | false | false | This superfamily represents a domain which consists of a 3-layer (α/β/α) sandwich, and it is found in the enzymes 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase and N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, as well as in uncharacterised putative deacetylases. | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:3.40.50.10320",
"SSF102588"
] | [
"",
""
] | [
50191,
50148
] | 2 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.1",
"3.5.1.103",
"R-BTA-162710",
"R-DDI-162710",
"R-HSA-162710",
"R-MMU-162710",
"R-MTU-879235",
"R-MTU-879299",
"R-MTU-879325",
"R-RNO-162710",
"R-SCE-162710",
"R-SPO-162710"
] | [
"EC:3.5.1",
"EC:3.5.1.103",
"REACTOME:R-BTA-162710",
"REACTOME:R-DDI-162710",
"REACTOME:R-HSA-162710",
"REACTOME:R-MMU-162710",
"REACTOME:R-MTU-879235",
"REACTOME:R-MTU-879299",
"REACTOME:R-MTU-879325",
"REACTOME:R-RNO-162710",
"REACTOME:R-SCE-162710",
"REACTOME:R-SPO-162710"
] | 12 | [
"1q74",
"1q7t",
"1uan",
"2ixd",
"2x9l",
"2xad",
"3dff",
"3dfi",
"3dfk",
"3dfm",
"3we7",
"3wl3",
"3wl4",
"4ewl",
"4xlz",
"4xm0",
"4xm1",
"4xm2",
"5b2e",
"5b2f",
"5bmo",
"5cgz",
"6iiy",
"6p2t",
"6ull",
"8bgn",
"8bgo",
"8bgp"
] | 28 | [
"PUB00020119",
"PUB00020988"
] | [
"10085243",
"12958317"
] | [
"Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis.",
"The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a... | [
1999,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
392,
42934,
5778,
55,
1219
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
15,
1,
2,
3,
1,
8,
3,
1,
2,
2,
1,
1,
17
] | 13 | true | Homologous_superfamily | Putative deacetylase LmbE-like domain superfamily | Putative deacetylase LmbE-like domain superfamily | LmbE-like_dom_sf | 5 |
IPR024079 | 24,079 | Metallopeptidase, catalytic domain superfamily | MetalloPept_cat_dom_sf | Homologous_superfamily | 284,507 | false | false | This superfamily represents the catalytic domain of different metallopeptidases. It consists of a three layer α-β-α sandwich. | [
"GO:0008237"
] | [
"metallopeptidase activity"
] | [
"molecular_function"
] | 1 | [
"CATHGENE3D"
] | [
"G3DSA:3.40.390.10"
] | [
""
] | [
284507
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.4.24",
"R-BTA-1433557",
"R-BTA-1442490",
"R-BTA-1474228",
"R-BTA-1592389",
"R-BTA-1650814",
"R-BTA-375276",
"R-BTA-381426",
"R-BTA-3928665",
"R-BTA-5173214",
"R-BTA-6798695",
"R-BTA-8957275",
"R-BTA-9009391",
"R-CEL-1442490",
"R-CEL-1474228",
"R-CEL-1592389",
"R-CEL-1650814",
"R... | [
"EC:3.4.24",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-1442490",
"REACTOME:R-BTA-1474228",
"REACTOME:R-BTA-1592389",
"REACTOME:R-BTA-1650814",
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-3928665",
"REACTOME:R-BTA-5173214",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-8957275... | 167 | [
"1a85",
"1a86",
"1af0",
"1akl",
"1ast",
"1atl",
"1ayk",
"1b3d",
"1b8y",
"1biw",
"1bkc",
"1bm6",
"1bqo",
"1bqq",
"1bsw",
"1bud",
"1buv",
"1bzs",
"1c3i",
"1c7k",
"1c8t",
"1caq",
"1cge",
"1cgf",
"1cgl",
"1ciz",
"1ck7",
"1cqr",
"1cxv",
"1d5j",
"1d7x",
"1d8f"... | 622 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1568,
88800,
192505,
283,
1351
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
33,
104,
293,
140,
3,
355,
304,
7,
22,
325,
3,
2,
28
] | 13 | true | Homologous_superfamily | Metallopeptidase, catalytic domain superfamily | Metallopeptidase, catalytic domain superfamily | MetalloPept_cat_dom_sf | 1 |
IPR024082 | 24,082 | Proline dehydrogenase PutA, domain II | PRODH_PutA_dom_II | Domain | 9,882 | false | false | This entry represents domain II of PutA. It has been suggested that this domain may be involved in DNA binding [ ]. The PutA flavoprotein from Escherichia coli plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of proline utilisation g... | [
"GO:0003842"
] | [
"L-glutamate gamma-semialdehyde dehydrogenase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF14850"
] | [
"Pro_dh-DNA_bdg"
] | [
9882
] | 1 | [
"EC",
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.1.88",
"1.5.5.2",
"GenProp1401",
"PWY-5737",
"PWY-6853",
"PWY-6922"
] | [
"EC:1.2.1.88",
"EC:1.5.5.2",
"GP:GenProp1401",
"METACYC:PWY-5737",
"METACYC:PWY-6853",
"METACYC:PWY-6922"
] | 6 | [
"1tiw",
"1tj0",
"1tj1",
"1tj2",
"2fzm",
"2fzn",
"3e2q",
"3e2r",
"3e2s",
"3haz",
"3itg",
"4jny",
"4jnz",
"4o8a",
"4q71",
"4q72",
"4q73",
"5kf6",
"5kf7",
"6bsn",
"6ufp",
"6vz9",
"6x99",
"6x9a",
"6x9b",
"6x9c",
"6x9d",
"7mwt",
"7mwu",
"7mwv",
"7my9",
"7mya"... | 54 | [
"PUB00026658"
] | [
"12514740"
] | [
"Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
9779,
30,
73
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Proline dehydrogenase PutA, domain II | Proline dehydrogenase PutA, domain II | PRODH_PutA_dom_II | 9 |
IPR024083 | 24,083 | Fumarase/histidase, N-terminal | Fumarase/histidase_N | Homologous_superfamily | 126,661 | false | false | This entry represents an N-terminal structural domain which forms an α-helical orthogonal bundle found in fumarate lyase (fumarase) and related proteins, as well as in histidine ammonia-lyase (or histidase) [ ]. One member of the fumarate lyase family is L-aspartate ammonia-lyase (aspartase), which catalyses the revers... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.275.10"
] | [
""
] | [
126661
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"4.3.2",
"R-BTA-70635",
"R-BTA-70921",
"R-CEL-70921",
"R-CEL-71403",
"R-CEL-9837999",
"R-DDI-70921",
"R-DDI-71403",
"R-DDI-9837999",
"R-DRE-71403",
"R-GGA-187630",
"R-GGA-70635",
"R-HSA-70635",
"R-HSA-70921",
"R-HSA-71403",
"R-HSA-9837999",
"R-MMU-70635",
"R-MMU-70921",
"R-MMU-71... | [
"EC:4.3.2",
"REACTOME:R-BTA-70635",
"REACTOME:R-BTA-70921",
"REACTOME:R-CEL-70921",
"REACTOME:R-CEL-71403",
"REACTOME:R-CEL-9837999",
"REACTOME:R-DDI-70921",
"REACTOME:R-DDI-71403",
"REACTOME:R-DDI-9837999",
"REACTOME:R-DRE-71403",
"REACTOME:R-GGA-187630",
"REACTOME:R-GGA-70635",
"REACTOME:R... | 32 | [
"1aos",
"1auw",
"1b8f",
"1c3c",
"1c3u",
"1dcn",
"1dof",
"1eb4",
"1f1o",
"1fuo",
"1fup",
"1fuq",
"1fur",
"1gk2",
"1gk3",
"1gkj",
"1gkm",
"1hy0",
"1hy1",
"1i0a",
"1j3u",
"1jsw",
"1k62",
"1k7w",
"1kq7",
"1q5n",
"1s3l",
"1s3m",
"1s3n",
"1t6j",
"1t6p",
"1tj7"... | 204 | [
"PUB00011785",
"PUB00023551"
] | [
"9230045",
"10220322"
] | [
"The structure of L-aspartate ammonia-lyase from Escherichia coli.",
"Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile."
] | [
1997,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2374,
102145,
20482,
10,
1650
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
40,
2,
12,
12,
4,
34,
10,
3,
38,
10,
2,
3,
87
] | 13 | true | Homologous_superfamily | Fumarase/histidase, N-terminal | Fumarase/histidase, N-terminal | Fumarase/histidase_N | 8 |
IPR024084 | 24,084 | Isopropylmalate dehydrogenase-like domain | IsoPropMal-DH-like_dom | Domain | 92,988 | false | false | The isocitrate and isopropylmalate dehydrogenases family includes isocitrate dehydrogenase (IDH), 3-isopropylmalate dehydrogenase (IMDH) and tartrate dehydrogenase. IDH is an important enzyme of carbohydrate metabolism which catalyses the oxidative decarboxylation of isocitrate into alpha-ketoglutarate [ , ]. IDH is ei... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF00180",
"SM01329"
] | [
"Iso_dh",
"Iso_dh"
] | [
92962,
90608
] | 2 | [
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"1.1.1",
"1.1.1.85",
"PWY-7396",
"R-BTA-2151201",
"R-BTA-71403",
"R-BTA-9837999",
"R-BTA-9854311",
"R-CEL-71403",
"R-CEL-9837999",
"R-DDI-389542",
"R-DDI-6798695",
"R-DDI-71403",
"R-DDI-9033241",
"R-DME-71403",
"R-DME-9837999",
"R-HSA-1268020",
"R-HSA-2151201",
"R-HSA-2978092",
"... | [
"EC:1.1.1",
"EC:1.1.1.85",
"METACYC:PWY-7396",
"REACTOME:R-BTA-2151201",
"REACTOME:R-BTA-71403",
"REACTOME:R-BTA-9837999",
"REACTOME:R-BTA-9854311",
"REACTOME:R-CEL-71403",
"REACTOME:R-CEL-9837999",
"REACTOME:R-DDI-389542",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-71403",
"REACTOME:R-DDI-90... | 47 | [
"1a05",
"1ai2",
"1ai3",
"1bl5",
"1cm7",
"1cnz",
"1cw1",
"1cw4",
"1cw7",
"1dpz",
"1dr0",
"1dr8",
"1g2u",
"1gc8",
"1gc9",
"1gro",
"1grp",
"1hex",
"1hj6",
"1hqs",
"1idc",
"1idd",
"1ide",
"1idf",
"1idm",
"1ika",
"1ipd",
"1iso",
"1lwd",
"1osi",
"1osj",
"1p8f"... | 240 | [
"PUB00000160",
"PUB00002669",
"PUB00003276",
"PUB00004691",
"PUB00005036",
"PUB00022856"
] | [
"8053675",
"1939242",
"1748999",
"2682654",
"7773180",
"9086278"
] | [
"Tartrate dehydrogenase, a new member of the family of metal-dependent decarboxylating R-hydroxyacid dehydrogenases.",
"NAD(+)-dependent isocitrate dehydrogenase. Cloning, nucleotide sequence, and disruption of the IDH2 gene from Saccharomyces cerevisiae.",
"Three-dimensional structure of a highly thermostable ... | [
1994,
1991,
1991,
1989,
1995,
1997
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1881,
53372,
36304,
11,
1420
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
53,
7,
8,
27,
4,
46,
23,
5,
27,
35,
7,
5,
73
] | 13 | true | Domain | Isopropylmalate dehydrogenase-like domain | Isopropylmalate dehydrogenase-like domain | IsoPropMal-DH-like_dom | 8 |
IPR024086 | 24,086 | Phosphoglucosamine mutase, archaeal type | GlmM_arc-type | Family | 4,602 | false | false | The entry represents a group of phosphoglucosamine mutases (encoded by gene GlmM) from archea and bacteria. MMP1680 protein from Methanococcus maripaludis in this family has been characterised as the archaeal protein responsible for the second step of UDP-GlcNAc biosynthesis [ ]. MMP1680 protein catalyses the conversio... | [
"GO:0008966"
] | [
"phosphoglucosamine mutase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM",
"CDD"
] | [
"TIGR03990",
"cd03087"
] | [
"Arch_GlmM",
"PGM_like1"
] | [
4459,
1493
] | 2 | [
"EC",
"GP",
"METACYC"
] | [
"5.4.2.10",
"GenProp0750",
"PWY-6749"
] | [
"EC:5.4.2.10",
"GP:GenProp0750",
"METACYC:PWY-6749"
] | 3 | [
"1wqa",
"2f7l",
"9du5",
"9ix8"
] | 4 | [
"PUB00034422",
"PUB00054937"
] | [
"16930487",
"18263721"
] | [
"Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.",
"Acetamido sugar biosynthesis in the Euryarchaea."
] | [
2006,
2008
] | 2 | [
"IPR005841"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1489,
3016,
26,
71
] | 4 | [] | [] | 0 | true | Family | Phosphoglucosamine mutase, archaeal type | Phosphoglucosamine mutase, archaeal type | GlmM_arc-type | 6 |
IPR024087 | 24,087 | Creatininase-like superfamily | Creatininase-like_sf | Homologous_superfamily | 14,557 | false | false | Creatinase ( ) catalyses the hydrolysis of creatinine to creatine, which can then be metabolised to urea and sarcosine by creatinase. Formamide hydrolase catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:3.40.50.10310",
"SSF102215"
] | [
"",
""
] | [
14532,
14552
] | 2 | [
"EC",
"METACYC"
] | [
"3.5.1.102",
"PWY-6167"
] | [
"EC:3.5.1.102",
"METACYC:PWY-6167"
] | 2 | [
"1j2t",
"1j2u",
"1q3k",
"1v7z",
"3a6d",
"3a6e",
"3a6f",
"3a6g",
"3a6h",
"3a6j",
"3a6k",
"3a6l",
"3lub",
"3no4"
] | 14 | [
"PUB00021871"
] | [
"15003455"
] | [
"Crystal structures of creatininase reveal the substrate binding site and provide an insight into the catalytic mechanism."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1421,
12677,
63,
396
] | 4 | [] | [] | 0 | true | Homologous_superfamily | Creatininase-like superfamily | Creatininase-like superfamily | Creatininase-like_sf | 6 |
IPR024088 | 24,088 | Tyrosine-tRNA ligase, bacterial-type | Tyr-tRNA-ligase_bac-type | Family | 32,754 | false | false | Two main groups can be distinguished among tyrosine-tRNA ligases: one group contains bacterial and organellar eukaryotic proteins and the other archaeal and cytosolic eukaryotic proteins. This entry represents the bacterial and organellar eukaryotic tyrosine-tRNA ligases. Tyrosine-tRNA ligases (TyrRS; also known as Tyr... | [
"GO:0004831"
] | [
"tyrosine-tRNA ligase activity"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR11766"
] | [
""
] | [
32754
] | 1 | [
"EC",
"REACTOME"
] | [
"6.1.1.1",
"R-HSA-379726"
] | [
"EC:6.1.1.1",
"REACTOME:R-HSA-379726"
] | 2 | [
"1h3e",
"1h3f",
"1jh3",
"1jii",
"1jij",
"1jik",
"1jil",
"1tya",
"1tyb",
"1tyc",
"1tyd",
"1vbm",
"1vbn",
"1wq3",
"1wq4",
"1x8x",
"1y42",
"2jan",
"2pid",
"2rkj",
"2ts1",
"2yxn",
"3ts1",
"3zxi",
"4ojm",
"4oud",
"4ts1",
"5ihx",
"5ijx",
"6bqy",
"6bqz",
"6byq"... | 43 | [
"PUB00000386",
"PUB00000723",
"PUB00004391",
"PUB00005365",
"PUB00006465",
"PUB00006477",
"PUB00007191",
"PUB00007363",
"PUB00055442",
"PUB00079872",
"PUB00079873"
] | [
"8364025",
"8274143",
"1852601",
"2053131",
"10630994",
"10673435",
"2203971",
"10447505",
"11590011",
"10704480",
"12458790"
] | [
"Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.",
"The aminoacyl-tRNA synthetase family: modules at work.",
"Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.",
"Classes of aminoacyl-tRNA synthetases and the establ... | [
1993,
1993,
1991,
1991,
2000,
2000,
1990,
1999,
2001,
2000,
2002
] | 11 | [
"IPR002307"
] | [
"IPR024107",
"IPR024108"
] | 1 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
27678,
4473,
10,
593
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
4,
2,
2,
1,
1,
2,
5,
1,
3,
5,
1,
1,
3
] | 13 | true | Family | Tyrosine-tRNA ligase, bacterial-type | Tyrosine-tRNA ligase, bacterial-type | Tyr-tRNA-ligase_bac-type | 5 |
IPR024089 | 24,089 | Proline dehydrogenase PutA, domain I/II | PRODH_PutA_dom_I/II | Homologous_superfamily | 9,861 | false | false | The PutA flavoprotein from Escherichia coli plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of proline utilisation genes [ ]. This entry spans domain I and II of PutA. | [
"GO:0003842"
] | [
"L-glutamate gamma-semialdehyde dehydrogenase activity"
] | [
"molecular_function"
] | 1 | [
"SSF"
] | [
"SSF81935"
] | [
""
] | [
9861
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.1.88",
"1.5.5.2",
"PWY-5737",
"PWY-6853",
"PWY-6922"
] | [
"EC:1.2.1.88",
"EC:1.5.5.2",
"METACYC:PWY-5737",
"METACYC:PWY-6853",
"METACYC:PWY-6922"
] | 5 | [
"1tiw",
"1tj0",
"1tj1",
"1tj2",
"2fzm",
"2fzn",
"3e2q",
"3e2r",
"3e2s",
"3haz",
"3itg",
"4jny",
"4jnz",
"4o8a",
"4q71",
"4q72",
"4q73",
"5kf6",
"5kf7",
"6bsn",
"6ufp",
"6vz9",
"6x99",
"6x9a",
"6x9b",
"6x9c",
"6x9d",
"7mwt",
"7mwu",
"7mwv",
"7my9",
"7mya"... | 64 | [
"PUB00026658"
] | [
"12514740"
] | [
"Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
9756,
32,
73
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Homologous_superfamily | Proline dehydrogenase PutA, domain I/II | Proline dehydrogenase PutA, domain I/II | PRODH_PutA_dom_I/II | 8 |
IPR024090 | 24,090 | Proline dehydrogenase PutA, domain I | PRODH_PutA_dom_I | Homologous_superfamily | 6,238 | false | false | The PutA flavoprotein from Escherichia coli plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of proline utilisation genes [ ]. This entry represents domain I of PutA. | [
"GO:0003842"
] | [
"L-glutamate gamma-semialdehyde dehydrogenase activity"
] | [
"molecular_function"
] | 1 | [
"CATHGENE3D"
] | [
"G3DSA:1.20.5.550"
] | [
""
] | [
6238
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.1.88",
"1.5.5.2",
"PWY-5737",
"PWY-6853",
"PWY-6922"
] | [
"EC:1.2.1.88",
"EC:1.5.5.2",
"METACYC:PWY-5737",
"METACYC:PWY-6853",
"METACYC:PWY-6922"
] | 5 | [
"1tiw",
"1tj0",
"1tj1",
"1tj2",
"2fzm",
"2fzn",
"3e2q",
"3e2r",
"3e2s",
"3itg",
"4jny",
"4jnz",
"4o8a",
"5kf6",
"5kf7",
"6ufp",
"6vz9",
"6x99",
"6x9a",
"6x9b",
"6x9c",
"6x9d",
"7mwt",
"7mwu",
"7mwv",
"7my9",
"7mya",
"7myb",
"7myc",
"7sqn",
"9bbo",
"9c34"... | 49 | [
"PUB00026658"
] | [
"12514740"
] | [
"Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
6213,
6,
19
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Homologous_superfamily | Proline dehydrogenase PutA, domain I | Proline dehydrogenase PutA, domain I | PRODH_PutA_dom_I | 2 |
IPR024091 | 24,091 | LnmK-like bifunctional acyltransferase/decarboxylase domain | LnmK-like_bifun_acyl/decarbox | Domain | 466 | false | false | The founding member of this family, LnmK from Streptomyces atroolivaceus, is a bifunctional enzyme that apparently carries out acyltransferase and decarboxylase reactions at the same active site [ , , ]. LnmK belongs to a polyketide biosynthetic gene cluster for leinamycin biosynthesis. This domain may occur in free-st... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR04098"
] | [
"LnmK_bifunc"
] | [
466
] | 1 | [] | [] | [] | 0 | [
"4hzn",
"4hzo",
"4hzp",
"6x7l",
"6x7m",
"6x7n",
"6x7o",
"6x7p"
] | 8 | [
"PUB00153590",
"PUB00153592",
"PUB00153593"
] | [
"33095002",
"33482062",
"21192727"
] | [
"The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2<i>R</i>)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis.",
"Structures of LnmK, a Bifunctional Acyltransferase/Decarboxylase, with Substrate Analogues Reveal the Basis for Selectivity and Stereospecificity... | [
2020,
2021,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
466
] | 1 | [] | [] | 0 | true | Domain | LnmK-like bifunctional acyltransferase/decarboxylase domain | LnmK-like bifunctional acyltransferase/decarboxylase domain | LnmK-like_bifun_acyl/decarbox | 3 |
IPR024093 | 24,093 | Uncharacterised protein family MTH865 | Uncharacterised_MTH865 | Family | 567 | false | false | This entry represents a group of uncharacterised hypothetical proteins from archaea and bacteria, including the 8.4kDa protein MTH865 from Methanobacterium thermoautotrophicum. The NMR structure of MTH865 reveals an EF-Hand-like fold consisting of four helices in two hairpins [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07747"
] | [
"MTH865"
] | [
567
] | 1 | [] | [] | [] | 0 | [
"1iio"
] | 1 | [
"PUB00013272"
] | [
"11693569"
] | [
"NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"ecological metagenomes"
] | [
22,
538,
7
] | 3 | [] | [] | 0 | true | Family | Uncharacterised protein family MTH865 | Uncharacterised protein family MTH865 | Uncharacterised_MTH865 | 5 |
IPR024094 | 24,094 | Cytochrome f large domain | Cyt_f_lg_dom | Domain | 15,262 | false | false | The cytochrome b6f integral membrane protein complex transfers electrons between the two reaction centre complexes of oxygenic photosynthetic membranes, and participates in formation of the transmembrane electrochemical proton gradient by also transferring protons from the stromal to the internal lumen compartment. The... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF16639"
] | [
"Apocytochr_F_N"
] | [
15262
] | 1 | [] | [] | [] | 0 | [
"1cfm",
"1ci3",
"1ctm",
"1e2v",
"1e2w",
"1e2z",
"1ewh",
"1hcz",
"1q90",
"1tkw",
"1tu2",
"1vf5",
"2d2c",
"2e74",
"2e75",
"2e76",
"2jxm",
"2pcf",
"2zt9",
"4h0l",
"4h13",
"4h44",
"4i7z",
"4ogq",
"4pv1",
"6rqf",
"7qrm",
"7r0w",
"7zxy",
"7zyv",
"9es7",
"9es8"... | 33 | [
"PUB00002369",
"PUB00005037",
"PUB00005442"
] | [
"8027021",
"8762139",
"7631417"
] | [
"Structural aspects of the cytochrome b6f complex; structure of the lumen-side domain of cytochrome f.",
"The heme redox center of chloroplast cytochrome f is linked to a buried five-water chain.",
"Cytochrome f revealed."
] | [
1994,
1996,
1995
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
382,
14879,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
9,
16
] | 3 | true | Domain | Cytochrome f large domain | Cytochrome f large domain | Cyt_f_lg_dom | 3 |
IPR024095 | 24,095 | Vesicle tethering protein p115 | Vesicle_P115 | Family | 6,190 | false | false | General vesicular transport factor P115, also known as USO1, is required for inter-cisternal transport in the Golgi stack and for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane [ , ]. It is required for both the formation of the Golgi stacks and the maintenance of the individual ci... | [
"GO:0048193"
] | [
"Golgi vesicle transport"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR10013"
] | [
""
] | [
6190
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-204005",
"R-BTA-6807878",
"R-DME-204005",
"R-DME-6807878",
"R-HSA-162658",
"R-HSA-204005",
"R-HSA-6807878",
"R-MMU-204005",
"R-MMU-6807878",
"R-RNO-204005",
"R-RNO-6807878",
"R-SCE-204005",
"R-SCE-6807878",
"R-SPO-204005",
"R-SPO-6807878"
] | [
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-6807878",
"REACTOME:R-DME-204005",
"REACTOME:R-DME-6807878",
"REACTOME:R-HSA-162658",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-6807878",
"REACTOME:R-MMU-204005",
"REACTOME:R-MMU-6807878",
"REACTOME:R-RNO-204005",
"REACTOME:R-RNO-6807878",
"REACTOME:R-SC... | 15 | [
"2w3c",
"3gq2",
"3grl",
"6lst",
"6lsu"
] | 5 | [
"PUB00055427",
"PUB00061386",
"PUB00155071"
] | [
"15800058",
"19414022",
"32533038"
] | [
"p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocation.",
"Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering.",
"Crystal structures of Uso1 membrane tether reveal an alternative confo... | [
2005,
2009,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
28,
6161,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
2,
6,
3,
1,
1,
1,
4,
6,
1,
1,
48
] | 12 | true | Family | Vesicle tethering protein p115 | Vesicle tethering protein p115 | Vesicle_P115 | 8 |
IPR024096 | 24,096 | NO signalling/Golgi transport ligand-binding domain superfamily | NO_sig/Golgi_transp_ligand-bd | Homologous_superfamily | 32,084 | false | false | This superfamily represents a domain is found in different trafficking protein particle complex (TRAPP) subunits involved in vesicular transport from the endoplasmic reticulum to Golgi [ ]. It is also found in soluble guanylate cyclases, where it binds heme via a covalent linkage to histidine [ ]. Soluble guanylate cyc... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF111126"
] | [
""
] | [
32084
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-204005",
"R-BTA-445355",
"R-BTA-8876198",
"R-CEL-204005",
"R-CEL-8876198",
"R-CFA-445355",
"R-DDI-204005",
"R-DDI-8876198",
"R-DME-445355",
"R-DRE-204005",
"R-GGA-204005",
"R-HSA-204005",
"R-HSA-392154",
"R-HSA-445355",
"R-HSA-8876198",
"R-MMU-204005",
"R-MMU-445355",
"R-MMU... | [
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-445355",
"REACTOME:R-BTA-8876198",
"REACTOME:R-CEL-204005",
"REACTOME:R-CEL-8876198",
"REACTOME:R-CFA-445355",
"REACTOME:R-DDI-204005",
"REACTOME:R-DDI-8876198",
"REACTOME:R-DME-445355",
"REACTOME:R-DRE-204005",
"REACTOME:R-GGA-204005",
"REACTOME:R-HSA-... | 27 | [
"1sz7",
"1u4h",
"1u55",
"1u56",
"1wc8",
"1wc9",
"1xbn",
"2bjn",
"2c0j",
"2cfh",
"2j3r",
"2j3t",
"2j3w",
"2kii",
"2kil",
"2o09",
"2o0c",
"2o0g",
"2osd",
"2oso",
"2pwn",
"3cue",
"3eee",
"3iqb",
"3kxc",
"3l6j",
"3lah",
"3lai",
"3m0b",
"3njc",
"3nvr",
"3nvu"... | 114 | [
"PUB00020479",
"PUB00031661"
] | [
"9564032",
"15326296"
] | [
"TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion.",
"Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases."
] | [
1998,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
799,
9476,
21708,
101
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
12,
13,
13,
27,
23,
4,
13,
52,
3,
3,
37
] | 12 | true | Homologous_superfamily | NO signalling/Golgi transport ligand-binding domain superfamily | NO signalling/Golgi transport ligand-binding domain superfamily | NO_sig/Golgi_transp_ligand-bd | 2 |
IPR024097 | 24,097 | Basic helix-loop-helix leucine zipper transcription factor | bHLH_ZIP_TF | Family | 11,050 | false | false | This family consists of different transcription factors that have a basic helix-loop-helix and a leucine zipper motif. Many different functions have been identified for these proteins in animals, including the control of cell proliferation and development of specific cell lineages [ ]. | [
"GO:0006355"
] | [
"regulation of DNA-templated transcription"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR12565"
] | [
""
] | [
11050
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055429"
] | [
"12679534"
] | [
"The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Plesiomonas shigelloides 302-73",
"Streptophyta"
] | [
1,
11049
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
73,
46,
185
] | 3 | true | Family | Basic helix-loop-helix leucine zipper transcription factor | Basic helix-loop-helix leucine zipper transcription factor | bHLH_ZIP_TF | 7 |
IPR024098 | 24,098 | Transcription factor EB, bHLHzip domain | bHLHzip_TFEB | Domain | 1,021 | false | false | The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC [ , ]. The transcription factors heterodimerize with each other and recognise the same DNA sequences [ ]. They recognise and bin... | [
"GO:0000978",
"GO:0046983",
"GO:0006959",
"GO:0045893"
] | [
"RNA polymerase II cis-regulatory region sequence-specific DNA binding",
"protein dimerization activity",
"humoral immune response",
"positive regulation of DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"CDD"
] | [
"cd18927"
] | [
"bHLHzip_TFEB"
] | [
1021
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9856649",
"R-HSA-9931510"
] | [
"REACTOME:R-HSA-9856649",
"REACTOME:R-HSA-9931510"
] | 2 | [
"7ux2",
"7uxc",
"7uxh"
] | 3 | [
"PUB00055428",
"PUB00055432",
"PUB00055433",
"PUB00055434",
"PUB00097581",
"PUB00101621",
"PUB00101622"
] | [
"15507434",
"7958932",
"16936731",
"9806910",
"31672913",
"30120233",
"35662396"
] | [
"Sumoylation of MITF and its related family members TFE3 and TFEB.",
"microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.",
"Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity.",
"The bHLH-Z... | [
2005,
1994,
2006,
1998,
2019,
2018,
2022
] | 7 | [
"IPR011598"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1021
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
5,
5,
5
] | 4 | true | Domain | Transcription factor EB, bHLHzip domain | Transcription factor EB, bHLHzip domain | bHLHzip_TFEB | 2 |
IPR024100 | 24,100 | Transcription factor E3, bHLHzip domain | bHLHzip_TFE3 | Domain | 296 | false | false | The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC [ , ]. The transcription factors heterodimerize with each other and recognise the same DNA sequences [ ]. They recognise and bin... | [
"GO:0000981",
"GO:0006959",
"GO:0045670",
"GO:0045893"
] | [
"DNA-binding transcription factor activity, RNA polymerase II-specific",
"humoral immune response",
"regulation of osteoclast differentiation",
"positive regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process"
] | 4 | [
"CDD"
] | [
"cd18928"
] | [
"bHLHzip_TFE3"
] | [
296
] | 1 | [
"REACTOME"
] | [
"R-HSA-9856649"
] | [
"REACTOME:R-HSA-9856649"
] | 1 | [] | 0 | [
"PUB00055428",
"PUB00055432",
"PUB00055433",
"PUB00055438",
"PUB00097581"
] | [
"15507434",
"7958932",
"16936731",
"11930005",
"31672913"
] | [
"Sumoylation of MITF and its related family members TFE3 and TFEB.",
"microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.",
"Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity.",
"Mitf and T... | [
2005,
1994,
2006,
2002,
2019
] | 5 | [
"IPR011598"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
296
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4,
3
] | 4 | true | Domain | Transcription factor E3, bHLHzip domain | Transcription factor E3, bHLHzip domain | bHLHzip_TFE3 | 6 |
IPR024104 | 24,104 | Pseudokinase tribbles family/serine-threonine-protein kinase 40 | Tribbles/Ser_Thr_kinase_40 | Family | 4,395 | false | false | Tribbles encode an evolutionarily conserved protein family that influences proliferation, motility, metabolism, and oncogenic transformation. Originally identified in Drosophila, tribbles homologues are characterised by a central serine/threonine kinase-like domain (KD) and a C-terminal binding site for E3 ubiquitin li... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22961"
] | [
""
] | [
4395
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-165158",
"R-CEL-1257604",
"R-CEL-165158",
"R-CEL-199418",
"R-CEL-389357",
"R-CEL-5218920",
"R-DME-1257604",
"R-DME-165158",
"R-DME-199418",
"R-DME-389357",
"R-DME-5218920",
"R-HSA-1257604",
"R-HSA-165158",
"R-HSA-1989781",
"R-HSA-199418",
"R-HSA-389357",
"R-HSA-5218920",
"R-... | [
"REACTOME:R-BTA-165158",
"REACTOME:R-CEL-1257604",
"REACTOME:R-CEL-165158",
"REACTOME:R-CEL-199418",
"REACTOME:R-CEL-389357",
"REACTOME:R-CEL-5218920",
"REACTOME:R-DME-1257604",
"REACTOME:R-DME-165158",
"REACTOME:R-DME-199418",
"REACTOME:R-DME-389357",
"REACTOME:R-DME-5218920",
"REACTOME:R-HSA... | 30 | [
"5cek",
"5cem",
"5l2q",
"6dc0",
"7upm"
] | 5 | [
"PUB00055439",
"PUB00055966"
] | [
"20410507",
"13679039"
] | [
"Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.",
"Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription."
] | [
2010,
2003
] | 2 | [] | [
"IPR024236"
] | 0 | 1 | 0 | [
"Armadillidium vulgare iridescent virus",
"Eukaryota"
] | [
2,
4393
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
1,
11,
7,
13
] | 6 | true | Family | Pseudokinase tribbles family/serine-threonine-protein kinase 40 | Pseudokinase tribbles family/serine-threonine-protein kinase 40 | Tribbles/Ser_Thr_kinase_40 | 2 |
IPR024107 | 24,107 | Tyrosine-tRNA ligase, bacterial-type, type 1 | Tyr-tRNA-ligase_bac_1 | Family | 19,380 | false | false | Tyrosine-tRNA ligases (TyrRS; also known as Tyrosyl-tRNA synthetases) ( ) are widely distributed, being found in archaea, bacteria and eukaryotes. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tR... | [
"GO:0004831"
] | [
"tyrosine-tRNA ligase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP"
] | [
"MF_02006"
] | [
"Tyr_tRNA_synth_type1"
] | [
19380
] | 1 | [
"EC"
] | [
"6.1.1.1"
] | [
"EC:6.1.1.1"
] | 1 | [
"1jii",
"1jij",
"1jik",
"1jil",
"1tya",
"1tyb",
"1tyc",
"1tyd",
"1x8x",
"2jan",
"2ts1",
"3ts1",
"4oud",
"4ts1",
"6hb5",
"6hb6",
"6hb7",
"6i5y",
"6n0w",
"6otj",
"7ap3"
] | 21 | [
"PUB00000386",
"PUB00000723",
"PUB00004391",
"PUB00005365",
"PUB00006465",
"PUB00006477",
"PUB00007191",
"PUB00007363",
"PUB00055442",
"PUB00079872",
"PUB00079873"
] | [
"8364025",
"8274143",
"1852601",
"2053131",
"10630994",
"10673435",
"2203971",
"10447505",
"11590011",
"10704480",
"12458790"
] | [
"Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.",
"The aminoacyl-tRNA synthetase family: modules at work.",
"Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.",
"Classes of aminoacyl-tRNA synthetases and the establ... | [
1993,
1993,
1991,
1991,
2000,
2000,
1990,
1999,
2001,
2000,
2002
] | 11 | [
"IPR024088"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
17692,
8,
1443,
237
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
1,
1,
1,
3,
3
] | 6 | true | Family | Tyrosine-tRNA ligase, bacterial-type, type 1 | Tyrosine-tRNA ligase, bacterial-type, type 1 | Tyr-tRNA-ligase_bac_1 | 9 |
IPR024108 | 24,108 | Tyrosine-tRNA ligase, bacterial-type, type 2 | Tyr-tRNA-ligase_bac_2 | Family | 7,877 | false | false | Tyrosine-tRNA ligases (TyrRS; also known as Tyrosyl-tRNA synthetases) ( ) are widely distributed, being found in archaea, bacteria and eukaryotes. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tR... | [
"GO:0004831"
] | [
"tyrosine-tRNA ligase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP"
] | [
"MF_02007"
] | [
"Tyr_tRNA_synth_type2"
] | [
7877
] | 1 | [
"EC"
] | [
"6.1.1.1"
] | [
"EC:6.1.1.1"
] | 1 | [
"1h3e",
"1h3f",
"6bqy",
"6bqz",
"6byq",
"9sdf",
"9sfb",
"9sfq"
] | 8 | [
"PUB00000386",
"PUB00000723",
"PUB00004391",
"PUB00005365",
"PUB00006465",
"PUB00006477",
"PUB00007191",
"PUB00007363",
"PUB00055442",
"PUB00079872",
"PUB00079873"
] | [
"8364025",
"8274143",
"1852601",
"2053131",
"10630994",
"10673435",
"2203971",
"10447505",
"11590011",
"10704480",
"12458790"
] | [
"Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.",
"The aminoacyl-tRNA synthetase family: modules at work.",
"Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.",
"Classes of aminoacyl-tRNA synthetases and the establ... | [
1993,
1993,
1991,
1991,
2000,
2000,
1990,
1999,
2001,
2000,
2002
] | 11 | [
"IPR024088"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7744,
16,
117
] | 3 | [] | [] | 0 | true | Family | Tyrosine-tRNA ligase, bacterial-type, type 2 | Tyrosine-tRNA ligase, bacterial-type, type 2 | Tyr-tRNA-ligase_bac_2 | 9 |
IPR024110 | 24,110 | Immunoglobulin J chain | Ig_J | Family | 575 | false | false | Immunoglobulin J serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to the secretory component [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF15097",
"PTHR10070"
] | [
"Ig_J_chain",
""
] | [
575,
574
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-202733",
"R-HSA-2168880",
"R-MMU-202733",
"R-MMU-2168880"
] | [
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-2168880",
"REACTOME:R-MMU-202733",
"REACTOME:R-MMU-2168880"
] | 4 | [
"6kxs",
"6lx3",
"6lxw",
"6ue7",
"6ue8",
"6ue9",
"6uea",
"7jg1",
"7jg2",
"7k0c",
"7y09",
"7y0h",
"7y0j",
"7yg2",
"7ysg",
"7ytc",
"7ytd",
"8ady",
"8adz",
"8ae0",
"8ae2",
"8ae3",
"8bpe",
"8bpf",
"8gzn",
"8r83",
"8r84",
"8sku",
"8skv",
"8wyr",
"8wys",
"9arv"... | 32 | [
"PUB00055443"
] | [
"10972899"
] | [
"Role of J chain in secretory immunoglobulin formation."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
575
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
2
] | 3 | true | Family | Immunoglobulin J chain | Immunoglobulin J chain | Ig_J | 4 |
IPR024111 | 24,111 | PEX5/PEX5L | PEX5/PEX5L | Family | 8,866 | false | false | Peroxisomal proteins catalyse metabolic reactions. The import of proteins from the cytosol into the peroxisomes matrix depends on more than a dozen peroxin (PEX) proteins, among which PEX5 and PEX7 serve as receptors that shuttle proteins bearing one of two peroxisome-targeting signals (PTSs) into the organelle. PEX5 i... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10130"
] | [
""
] | [
8866
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8866654",
"R-BTA-9033241",
"R-BTA-9664873",
"R-DDI-8866654",
"R-DDI-9033241",
"R-DDI-9664873",
"R-HSA-8866654",
"R-HSA-9033241",
"R-HSA-9664873",
"R-MMU-8866654",
"R-MMU-9033241",
"R-MMU-9664873",
"R-RNO-8866654",
"R-RNO-9033241",
"R-RNO-9664873",
"R-SCE-8866654",
"R-SCE-90332... | [
"REACTOME:R-BTA-8866654",
"REACTOME:R-BTA-9033241",
"REACTOME:R-BTA-9664873",
"REACTOME:R-DDI-8866654",
"REACTOME:R-DDI-9033241",
"REACTOME:R-DDI-9664873",
"REACTOME:R-HSA-8866654",
"REACTOME:R-HSA-9033241",
"REACTOME:R-HSA-9664873",
"REACTOME:R-MMU-8866654",
"REACTOME:R-MMU-9033241",
"REACTOM... | 21 | [
"1fch",
"1hxi",
"2c0l",
"2c0m",
"2j9q",
"3cv0",
"3cvl",
"3cvn",
"3cvp",
"3cvq",
"3r9a",
"4eqf",
"4kxk",
"4kyo",
"8ggd",
"8ggh",
"8gh2",
"8gh3",
"8gi0",
"8os1",
"9f8w",
"9fef",
"9fh0",
"9gag"
] | 24 | [
"PUB00055445",
"PUB00055446",
"PUB00055447",
"PUB00055448",
"PUB00096372",
"PUB00096373",
"PUB00096375",
"PUB00096376"
] | [
"11606046",
"16428307",
"11865044",
"11463335",
"20130089",
"15548601",
"22550182",
"32189562"
] | [
"Temperature-sensitive phenotype of Chinese hamster ovary cells defective in PEX5 gene.",
"Identification of Pex5pM, and retarded maturation of 3-ketoacyl-CoA thiolase and acyl-CoA oxidase in CHO cells expressing mutant Pex5p isoforms.",
"Peroxisomal targeting signal receptor Pex5p interacts with cargoes and im... | [
2001,
2005,
2002,
2001,
2010,
2005,
2012,
2020
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
22,
8840,
4
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
5,
24,
2,
20,
14,
2,
7,
17,
2,
1,
43
] | 11 | true | Family | PEX5/PEX5L | PEX5/PEX5L | PEX5/PEX5L | 4 |
IPR024114 | 24,114 | Islet cell autoantigen 1/Ica1-like | Islet_autoAg_Ica1/Ica1-like | Family | 3,235 | false | false | Islet cell autoantigen 1 (Ica1) and its Caenorhabditis elegans homologue, Ric19 (resistance to inhibitors of cholinesterase protein 19), may play a role in neurotransmitter secretion [ ]. This entry includes Ica1 and homologues, and also proteins known as Ica1-like, which are found in mammals and whose function has not... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10164"
] | [
""
] | [
3235
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055450"
] | [
"11029035"
] | [
"The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
3235
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
55,
1,
28,
12,
15
] | 6 | true | Family | Islet cell autoantigen 1/Ica1-like | Islet cell autoantigen 1/Ica1-like | Islet_autoAg_Ica1/Ica1-like | 9 |
IPR024119 | 24,119 | Transcription factor DEAF-1 | TF_DEAF-1 | Family | 3,992 | false | false | Deformed epidermal autoregulatory factor-1 (DEAF-1) was first isolated in Drosophila melanogaster as a novel DNA-binding protein [ ]. Since then, several orthologues in mammals have been identified. In Drosophila, DEAF-1 plays an important role in embryonic development, particularly in the segmentation stage following ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10237"
] | [
""
] | [
3992
] | 1 | [] | [] | [] | 0 | [
"2jw6",
"4a24"
] | 2 | [
"PUB00001283",
"PUB00055451",
"PUB00055452",
"PUB00155078"
] | [
"8617243",
"18826651",
"14966286",
"24726472"
] | [
"DEAF-1, a novel protein that binds an essential region in a Deformed response element.",
"Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland.",
"Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-... | [
1996,
2008,
2004,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonas gingeri",
"viral metagenome"
] | [
3987,
1,
4
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
2,
5,
13,
8,
2,
6
] | 6 | true | Family | Transcription factor DEAF-1 | Transcription factor DEAF-1 | TF_DEAF-1 | 9 |
IPR024128 | 24,128 | T-cell surface glycoprotein CD3 zeta subunit | T-cell_CD3_zeta | Family | 1,015 | false | false | The TCR complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer co-expressed at the cell surface with the invariant subunits of CD3 labelled gamma, delta, epsilon, zeta, and eta [ ]. The zeta subunit forms either homodimers or heterodimers with eta [ ], but eta homodimers have not be... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10035"
] | [
""
] | [
1015
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-164944",
"R-HSA-198933",
"R-HSA-202424",
"R-HSA-202427",
"R-HSA-202430",
"R-HSA-202433",
"R-HSA-2029481",
"R-HSA-2029482",
"R-HSA-2029485",
"R-HSA-389948",
"R-HSA-9664323",
"R-HSA-9664422",
"R-MMU-198933",
"R-MMU-202424",
"R-MMU-202427",
"R-MMU-202430",
"R-MMU-202433",
"R-MM... | [
"REACTOME:R-HSA-164944",
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-202424",
"REACTOME:R-HSA-202427",
"REACTOME:R-HSA-202430",
"REACTOME:R-HSA-202433",
"REACTOME:R-HSA-2029481",
"REACTOME:R-HSA-2029482",
"REACTOME:R-HSA-2029485",
"REACTOME:R-HSA-389948",
"REACTOME:R-HSA-9664323",
"REACTOME:R-HSA... | 21 | [
"2hac",
"3ioz",
"6jxr",
"7fjd",
"7fje",
"7fjf",
"7phr",
"8es7",
"8es8",
"8es9",
"8j8i",
"8jc0",
"8jcb",
"8tw4",
"8tw6",
"8wxe",
"8wy0",
"8wyi",
"8yc0",
"8za6",
"9bbc",
"9c3e",
"9ci8",
"9cia",
"9cq4",
"9jxz",
"9jy0",
"9jy1"
] | 28 | [
"PUB00041339",
"PUB00055464",
"PUB00055465"
] | [
"17055436",
"9072162",
"8112294"
] | [
"The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.",
"T-cell receptors: feeling out the complex.",
"Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse."
] | [
2006,
1997,
1994
] | 3 | [
"IPR021663"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1015
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
17,
4,
5
] | 4 | true | Family | T-cell surface glycoprotein CD3 zeta subunit | T-cell surface glycoprotein CD3 zeta subunit | T-cell_CD3_zeta | 6 |
IPR024129 | 24,129 | Sphingomyelin phosphodiesterase 4 | Sphingomy_SMPD4 | Family | 3,271 | false | false | Sphingomyelin phosphodiesterase 4 (also known as neutral sphingomyelinase 3) catalyses the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide [ ]. | [
"GO:0050290"
] | [
"sphingomyelin phosphodiesterase D activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF14724",
"PTHR12988"
] | [
"mit_SMPDase",
""
] | [
3101,
2920
] | 2 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.4.12",
"PWY-7277",
"R-DRE-9840310",
"R-HSA-9840310",
"R-MMU-9840310"
] | [
"EC:3.1.4.12",
"METACYC:PWY-7277",
"REACTOME:R-DRE-9840310",
"REACTOME:R-HSA-9840310",
"REACTOME:R-MMU-9840310"
] | 5 | [] | 0 | [
"PUB00055468"
] | [
"16517606"
] | [
"Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3271
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
22,
13,
9
] | 6 | true | Family | Sphingomyelin phosphodiesterase 4 | Sphingomyelin phosphodiesterase 4 | Sphingomy_SMPD4 | 3 |
IPR024130 | 24,130 | DAP1/DAPL1 | DAP1/DAPL1 | Family | 2,285 | false | false | This family includes death-associated protein 1 (DAP1) and death-associated protein-like 1 (DAPL1). DAP1 is involved in mediating interferon-gamma-induced cell death [ ]. DAPL1 may play a role in the early stages of epithelial differentiation or in apoptosis [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF15228",
"PTHR13177"
] | [
"DAP",
""
] | [
2277,
1715
] | 2 | [] | [] | [] | 0 | [
"7oya",
"7oyc",
"7oyd"
] | 3 | [
"PUB00055469",
"PUB00055470"
] | [
"7828849",
"15920738"
] | [
"Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.",
"EEDA: a protein associated with an early stage of stratified epithelial differentiation."
] | [
1995,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2285
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
1,
11,
5,
6
] | 6 | true | Family | DAP1/DAPL1 | DAP1/DAPL1 | DAP1/DAPL1 | 2 |
IPR024131 | 24,131 | Peptide arginase FlmR/OhkR-like | FlmR/OhkR-like | Family | 2,309 | false | false | This entry describes a family of uncharacterised proteins found in animals and bacteria, including FlmR from Flagellimonas meridianipacifica (WP_106143370, ) and OhkR from Ohtaekwangia koreensis (WP_159453773, ), which have been reported to be peptide arginases that modify Arg residues to ornithine in bioactive RiPP pe... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12640",
"PTHR13225"
] | [
"UPF0489",
""
] | [
2127,
1985
] | 2 | [] | [] | [] | 0 | [
"8brp"
] | 1 | [
"PUB00162570"
] | [
"41201059"
] | [
"Peptide Arginases from Cryptic Pathways Install Ornithine Residues in Uncharacterized Members of Orphan RiPP Families."
] | [
2025
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanococcaceae",
"metagenomes"
] | [
272,
2002,
23,
12
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
3,
4,
2,
5
] | 6 | true | Family | Peptide arginase FlmR/OhkR-like | Peptide arginase FlmR/OhkR-like | FlmR/OhkR-like | 9 |
IPR024132 | 24,132 | Akirin | Akirin | Family | 2,777 | false | false | Akirin is a molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is required for embryonic development and for normal innate immune response[ , ]. It plays a central role in immune gene expression in insects and mammals, linking the SWI/SNF chromatin-remodelling complex with th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13293"
] | [
""
] | [
2777
] | 1 | [] | [] | [] | 0 | [
"7nht"
] | 1 | [
"PUB00055471",
"PUB00093086",
"PUB00100784",
"PUB00100785"
] | [
"18066067",
"30036395",
"32950464",
"34711951"
] | [
"Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.",
"Evolutionary plasticity in the innate immune function of Akirin.",
"Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster.",
"AKIR... | [
2008,
2018,
2021,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2777
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
3,
5,
2,
4
] | 6 | true | Family | Akirin | Akirin | Akirin | 5 |
IPR024133 | 24,133 | Transmembrane protein 138 | TM_138 | Family | 1,683 | false | false | This entry represents a family of uncharacterised proteins that have been termed transmembrane protein 138. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF14935",
"PTHR13306"
] | [
"TMEM138",
""
] | [
1679,
1569
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1683
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
8,
3,
3
] | 6 | true | Family | Transmembrane protein 138 | Transmembrane protein 138 | TM_138 | 7 |
IPR024134 | 24,134 | Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone | SOD_Cu/Zn_/chaperone | Family | 24,086 | false | false | Superoxide dismutases (SODs) are ubiquitous metalloproteins that prevent damage by oxygen-mediated free radicals by catalysing the dismutation of superoxide into molecular oxygen and hydrogen peroxide [ ]. Superoxide is a normal by-product of aerobic respiration and is produced by a number of reactions, including oxida... | [
"GO:0005507"
] | [
"copper ion binding"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR10003"
] | [
""
] | [
24086
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"1.15.1.1",
"PWY-6854",
"R-BTA-114608",
"R-BTA-3299685",
"R-CEL-114608",
"R-CEL-3299685",
"R-DDI-114608",
"R-DDI-3299685",
"R-DME-114608",
"R-DME-3299685",
"R-DRE-114608",
"R-DRE-3299685",
"R-HSA-114608",
"R-HSA-1222387",
"R-HSA-3299685",
"R-HSA-8950505",
"R-HSA-9818027",
"R-MMU-11... | [
"EC:1.15.1.1",
"METACYC:PWY-6854",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-3299685",
"REACTOME:R-CEL-114608",
"REACTOME:R-CEL-3299685",
"REACTOME:R-DDI-114608",
"REACTOME:R-DDI-3299685",
"REACTOME:R-DME-114608",
"REACTOME:R-DME-3299685",
"REACTOME:R-DRE-114608",
"REACTOME:R-DRE-3299685",
"R... | 29 | [
"1azv",
"1b4l",
"1b4t",
"1ba9",
"1bzo",
"1cb4",
"1cbj",
"1cob",
"1do5",
"1dsw",
"1e9o",
"1e9p",
"1e9q",
"1eqw",
"1eso",
"1f18",
"1f1a",
"1f1d",
"1f1g",
"1fun",
"1hl4",
"1hl5",
"1ib5",
"1ibb",
"1ibd",
"1ibf",
"1ibh",
"1jcv",
"1jk9",
"1kmg",
"1l3n",
"1mfm"... | 264 | [
"PUB00000151",
"PUB00001545",
"PUB00004722",
"PUB00004789",
"PUB00066190"
] | [
"2751312",
"3891411",
"2263641",
"1463506",
"10694572"
] | [
"Primary structure from amino acid and cDNA sequences of two Cu,Zn superoxide dismutase variants from Xenopus laevis.",
"Primary structure of porcine Cu,Zn superoxide dismutase.",
"Characterization of iron superoxide dismutase cDNAs from plants obtained by genetic complementation in Escherichia coli.",
"Atomi... | [
1989,
1985,
1990,
1992,
2000
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"Viruses",
"metagenomes"
] | [
9693,
14021,
20,
217,
135
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
22,
4,
11,
11,
1,
11,
11,
2,
13,
17,
2,
1,
61
] | 13 | true | Family | Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone | Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone | SOD_Cu/Zn_/chaperone | 2 |
IPR024135 | 24,135 | Ragulator complex protein LAMTOR5 | LAMTOR5 | Family | 1,793 | false | false | Hepatitis B X-interacting protein (HBXIP, also known as LAMTOR5) was originally recognised for its association with the X protein of hepatitis B virus (HBV) and ability to down-regulate HBV replication [ ]. When complexed to the anti-apoptotic protein survivin, HBXIP interferes with apoptosome assembly, preventing recr... | [
"GO:0043066",
"GO:0005737",
"GO:0071986"
] | [
"negative regulation of apoptotic process",
"cytoplasm",
"Ragulator complex"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF16672",
"PR02092",
"PTHR13342"
] | [
"LAMTOR5",
"HEPBVIRUSXIP",
""
] | [
1787,
1099,
1555
] | 3 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp2031",
"R-BTA-1632852",
"R-BTA-165159",
"R-BTA-166208",
"R-BTA-380972",
"R-BTA-5628897",
"R-BTA-8943724",
"R-BTA-9639288",
"R-DDI-1632852",
"R-DDI-165159",
"R-DDI-166208",
"R-DDI-380972",
"R-DDI-5628897",
"R-DDI-8943724",
"R-DDI-9639288",
"R-HSA-1632852",
"R-HSA-165159",
"R... | [
"GP:GenProp2031",
"REACTOME:R-BTA-1632852",
"REACTOME:R-BTA-165159",
"REACTOME:R-BTA-166208",
"REACTOME:R-BTA-380972",
"REACTOME:R-BTA-5628897",
"REACTOME:R-BTA-8943724",
"REACTOME:R-BTA-9639288",
"REACTOME:R-DDI-1632852",
"REACTOME:R-DDI-165159",
"REACTOME:R-DDI-166208",
"REACTOME:R-DDI-38097... | 41 | [
"3ms6",
"3msh",
"5vok",
"5x6u",
"5x6v",
"5y38",
"5y39",
"5y3a",
"5yk3",
"5yk5",
"6b9x",
"6ehp",
"6ehr",
"6nzd",
"6u62",
"6ulg",
"6wj2",
"6wj3",
"7t3a",
"7t3b",
"7t3c",
"7ux2",
"7uxc",
"7uxh",
"8dhb",
"9ed4",
"9ed6"
] | 27 | [
"PUB00055472",
"PUB00055473",
"PUB00068038",
"PUB00076183"
] | [
"12773388",
"9499022",
"22980980",
"26084023"
] | [
"HBXIP functions as a cofactor of survivin in apoptosis suppression.",
"Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication.",
"Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.",
"Complement Regulates Nutrient Influx and Me... | [
2003,
1998,
2012,
2015
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1793
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
4,
2,
3
] | 6 | true | Family | Ragulator complex protein LAMTOR5 | Ragulator complex protein LAMTOR5 | LAMTOR5 | 4 |
IPR024137 | 24,137 | Histone deacetylase complex subunit SAP130 | His_deAcase_cplx_SAP130 | Family | 2,508 | false | false | Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors is regulated by enzymes that acetylate and deacetylate histones. The Sin3A-histone deacetylase (HDAC) co-repressor complex consists of multiple proteins and regulates ge... | [
"GO:0006355"
] | [
"regulation of DNA-templated transcription"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR13497"
] | [
""
] | [
2508
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-3214847",
"R-HSA-427413"
] | [
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-427413"
] | 2 | [] | 0 | [
"PUB00055474"
] | [
"12724404"
] | [
"Identification and characterization of three new components of the mSin3A corepressor complex."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2508
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
7,
7,
3,
5
] | 5 | true | Family | Histone deacetylase complex subunit SAP130 | Histone deacetylase complex subunit SAP130 | His_deAcase_cplx_SAP130 | 9 |
IPR024138 | 24,138 | Pericentriolar material 1 protein | Pericentriolar_Pcm1 | Family | 3,401 | false | false | Pericentriolar material 1 protein is required for centrosome assembly and function. It is essential for the correct localisation of several centrosomal proteins and required to anchor microtubules to the centrosome [ ]. It is probably involved in the biogenesis of cilia [ ]. | [
"GO:0034454",
"GO:0060271",
"GO:0071539",
"GO:0005813"
] | [
"microtubule anchoring at centrosome",
"cilium assembly",
"protein localization to centrosome",
"centrosome"
] | [
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PANTHER"
] | [
"PTHR14164"
] | [
""
] | [
3401
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-2565942",
"R-GGA-380259",
"R-GGA-380270",
"R-GGA-380284",
"R-GGA-380320",
"R-GGA-5620912",
"R-GGA-8854518",
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-... | [
"REACTOME:R-GGA-2565942",
"REACTOME:R-GGA-380259",
"REACTOME:R-GGA-380270",
"REACTOME:R-GGA-380284",
"REACTOME:R-GGA-380320",
"REACTOME:R-GGA-5620912",
"REACTOME:R-GGA-8854518",
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA... | 21 | [] | 0 | [
"PUB00055475",
"PUB00055476"
] | [
"12112146",
"10579718"
] | [
"Arrest of cell cycle progression during first interphase in murine zygotes microinjected with anti-PCM-1 antibodies.",
"Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis."
] | [
2002,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3401
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
51,
13,
3,
9
] | 4 | true | Family | Pericentriolar material 1 protein | Pericentriolar material 1 protein | Pericentriolar_Pcm1 | 4 |
IPR024140 | 24,140 | Phorbol-12-myristate-13-acetate-induced protein 1 | Noxa | Family | 261 | false | false | Phorbol-12-myristate-13-acetate-induced protein 1, also known as Noxa, is a p53 transcriptional target involved in the response to DNA-damaging agents [ ]. Noxa can also be activated by other transcriptional factors, suggesting a broad role in the response to cellular stresses. It has been shown to promote activation o... | [
"GO:0001836",
"GO:0006915",
"GO:0006974",
"GO:0043065"
] | [
"release of cytochrome c from mitochondria",
"apoptotic process",
"DNA damage response",
"positive regulation of apoptotic process"
] | [
"biological_process",
"biological_process",
"biological_process",
"biological_process"
] | 4 | [
"PFAM",
"PANTHER"
] | [
"PF15150",
"PTHR14299"
] | [
"PMAIP1",
""
] | [
261,
221
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-111448",
"R-CFA-111453",
"R-HSA-111448",
"R-HSA-111453",
"R-HSA-6803204",
"R-MMU-111448",
"R-MMU-111453",
"R-RNO-111448",
"R-RNO-111453"
] | [
"REACTOME:R-CFA-111448",
"REACTOME:R-CFA-111453",
"REACTOME:R-HSA-111448",
"REACTOME:R-HSA-111453",
"REACTOME:R-HSA-6803204",
"REACTOME:R-MMU-111448",
"REACTOME:R-MMU-111453",
"REACTOME:R-RNO-111448",
"REACTOME:R-RNO-111453"
] | 9 | [
"2jm6",
"2nla",
"3mqp",
"4g35"
] | 4 | [
"PUB00055480",
"PUB00055481",
"PUB00055482"
] | [
"20085765",
"12952892",
"14699081"
] | [
"Noxa is necessary for hydrogen peroxide-induced caspase-dependent cell death.",
"Integral role of Noxa in p53-mediated apoptotic response.",
"BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha."
] | [
2010,
2003,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
261
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
3,
3
] | 4 | true | Family | Phorbol-12-myristate-13-acetate-induced protein 1 | Phorbol-12-myristate-13-acetate-induced protein 1 | Noxa | 9 |
IPR024145 | 24,145 | Histone deacetylase complex subunit SAP30/SAP30-like | His_deAcase_SAP30/SAP30L | Family | 4,951 | false | false | Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors is regulated by enzymes that acetylate and deacetylate histones. The Sin3A-histone deacetylase (HDAC) co-repressor complex consists of multiple proteins and regulates ge... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13286"
] | [
""
] | [
4951
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-3214815",
"R-HSA-3214815",
"R-HSA-427413",
"R-HSA-9679191",
"R-MMU-3214815",
"R-SCE-3214815",
"R-XTR-3214815"
] | [
"REACTOME:R-DME-3214815",
"REACTOME:R-HSA-3214815",
"REACTOME:R-HSA-427413",
"REACTOME:R-HSA-9679191",
"REACTOME:R-MMU-3214815",
"REACTOME:R-SCE-3214815",
"REACTOME:R-XTR-3214815"
] | 7 | [
"2kdp",
"2ld7",
"2n1u",
"8ga8",
"8hpo"
] | 5 | [
"PUB00055485"
] | [
"16820529"
] | [
"SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4951
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
12,
1,
2,
2,
2,
1,
12,
3,
1,
11
] | 10 | true | Family | Histone deacetylase complex subunit SAP30/SAP30-like | Histone deacetylase complex subunit SAP30/SAP30-like | His_deAcase_SAP30/SAP30L | 6 |
IPR024146 | 24,146 | Claspin | Claspin | Family | 2,943 | false | false | Claspin is an essential protein for the ATR-Chk1-dependent activation of the DNA replication checkpoint response in Xenopus and human cells [ , ]. DNA damage induces the formation of a complex between Claspin and BRCA1, a second regulator of Chk1 activation. It is thought that ATR regulates Claspin phosphorylation in r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14396"
] | [
""
] | [
2943
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-176187",
"R-DME-5693607",
"R-HSA-111465",
"R-HSA-176187",
"R-HSA-5689880",
"R-HSA-5693607",
"R-MMU-111465",
"R-MMU-176187",
"R-MMU-5689880",
"R-MMU-5693607",
"R-SCE-176187",
"R-SCE-5689880",
"R-SPO-176187",
"R-SPO-5689880"
] | [
"REACTOME:R-DME-176187",
"REACTOME:R-DME-5693607",
"REACTOME:R-HSA-111465",
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-5689880",
"REACTOME:R-HSA-5693607",
"REACTOME:R-MMU-111465",
"REACTOME:R-MMU-176187",
"REACTOME:R-MMU-5689880",
"REACTOME:R-MMU-5693607",
"REACTOME:R-SCE-176187",
"REACTOME:R-SC... | 14 | [
"7pfo",
"7plo",
"8b9a",
"8b9b",
"8b9c",
"8b9d",
"8xgc"
] | 7 | [
"PUB00055486",
"PUB00055487",
"PUB00055488"
] | [
"12766152",
"11090622",
"15096610"
] | [
"Human claspin is required for replication checkpoint control.",
"Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts.",
"Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation."
] | [
2003,
2000,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2943
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
6,
1,
4,
5,
1,
3,
1,
1
] | 9 | true | Family | Claspin | Claspin | Claspin | 9 |
IPR024149 | 24,149 | Paralemmin-3 | Paralemmin-3 | Family | 511 | false | false | Paralemmin-3 is a member of the paralemmin protein family [ ] and may function as an adaptor in the LPS- Toll-like receptor 4 signalling [ ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47528"
] | [
""
] | [
511
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055489",
"PUB00055490"
] | [
"11478809",
"21187075"
] | [
"The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative.",
"A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3."
] | [
2001,
2011
] | 2 | [
"IPR004965"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
511
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
1,
4
] | 4 | true | Family | Paralemmin-3 | Paralemmin-3 | Paralemmin-3 | 6 |
IPR024152 | 24,152 | Inhibitor of nuclear factor kappa-B kinase-interacting protein | Inh_kappa-B_kinase-int | Family | 1,188 | false | false | IKIP (I kappa B kinase interacting protein) is a p53 target gene with proapoptotic function [ ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21734"
] | [
""
] | [
1188
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-BTA-9758274",
"R-HSA-9758274"
] | [
"REACTOME:R-BTA-9758274",
"REACTOME:R-HSA-9758274"
] | 2 | [] | 0 | [
"PUB00055491"
] | [
"15389287"
] | [
"A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1188
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
2,
5
] | 4 | true | Family | Inhibitor of nuclear factor kappa-B kinase-interacting protein | Inhibitor of nuclear factor kappa-B kinase-interacting protein | Inh_kappa-B_kinase-int | 5 |
IPR024153 | 24,153 | Suprabasin | Suprabasin | Family | 437 | false | false | Suprabasin (SBN) is expressed in mouse and human differentiating keratinocytes, being involved in epidermal differentiation which may play a role in skin barrier formation [ ]. It has been proposed to be a component of the cornified envelope, an essential structure for skin protection [ , ]. Its exact function is not y... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23243"
] | [
""
] | [
437
] | 1 | [
"REACTOME"
] | [
"R-HSA-9725554"
] | [
"REACTOME:R-HSA-9725554"
] | 1 | [] | 0 | [
"PUB00055492",
"PUB00151663",
"PUB00151664",
"PUB00151665"
] | [
"12228223",
"34322491",
"33477529",
"35222534"
] | [
"Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor.",
"New Family Members of FG Repeat Proteins and Their Unexplored Roles During Phase Separation.",
"Suprabasin-A Review.",
"Role of Suprabasin in the Dedifferentiation of Follicular Epithelial Cell-Derived Thyroid... | [
2002,
2021,
2021,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
14,
422,
1
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
7
] | 3 | true | Family | Suprabasin | Suprabasin | Suprabasin | 3 |
IPR024156 | 24,156 | Small GTPase superfamily, ARF type | Small_GTPase_ARF | Family | 47,534 | false | false | This entry represents a branch of the small GTPase superfamily that includes the ADP ribosylation factor Arf, Arl (Arf-like), and Arp (Arf-related proteins). Arf proteins are major regulators of vesicle biogenesis in intracellular traffic [ ]. They cycle between inactive GDP-bound and active GTP-bound forms that bind s... | [
"GO:0005525"
] | [
"GTP binding"
] | [
"molecular_function"
] | 1 | [
"PANTHER",
"PANTHER"
] | [
"PTHR11711",
"PTHR45909"
] | [
"",
""
] | [
41271,
6263
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1660499",
"R-BTA-1660514",
"R-BTA-199992",
"R-BTA-2132295",
"R-BTA-432720",
"R-BTA-432722",
"R-BTA-5620916",
"R-BTA-5620922",
"R-BTA-6807878",
"R-BTA-6811434",
"R-BTA-6811438",
"R-BTA-6811440",
"R-BTA-9845576",
"R-CEL-1660514",
"R-CEL-199992",
"R-CEL-432720",
"R-CEL-432722",
... | [
"REACTOME:R-BTA-1660499",
"REACTOME:R-BTA-1660514",
"REACTOME:R-BTA-199992",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-432720",
"REACTOME:R-BTA-432722",
"REACTOME:R-BTA-5620916",
"REACTOME:R-BTA-5620922",
"REACTOME:R-BTA-6807878",
"REACTOME:R-BTA-6811434",
"REACTOME:R-BTA-6811438",
"REACTOME:R... | 116 | [
"1e0s",
"1hur",
"1j2j",
"1moz",
"1mr3",
"1o3y",
"1r4a",
"1r8q",
"1r8s",
"1re0",
"1rrf",
"1rrg",
"1s9d",
"1u81",
"1upt",
"1yzg",
"1z6x",
"1z6y",
"1zj6",
"2a5d",
"2a5f",
"2a5g",
"2b6h",
"2fh5",
"2go5",
"2h16",
"2h17",
"2h57",
"2j59",
"2j5x",
"2k5u",
"2ksq"... | 119 | [
"PUB00000348",
"PUB00004087",
"PUB00009830",
"PUB00015117",
"PUB00023196",
"PUB00036002",
"PUB00052600",
"PUB00117369"
] | [
"2029511",
"1898771",
"12429613",
"11995995",
"2196171",
"7844142",
"2122258",
"12759365"
] | [
"The ras protein family: evolutionary tree and role of conserved amino acids.",
"The GTPase superfamily: conserved structure and molecular mechanism.",
"Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication.",
"Structure of small G proteins an... | [
1991,
1991,
2002,
2001,
1990,
1995,
1990,
2003
] | 8 | [] | [
"IPR019009"
] | 0 | 1 | 0 | [
"Archaea",
"Ectobacillus ponti",
"Eukaryota",
"marine sediment metagenome"
] | [
33,
1,
47456,
44
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
51,
9,
33,
17,
77,
55,
4,
41,
71,
5,
2,
103
] | 12 | true | Family | Small GTPase superfamily, ARF type | Small GTPase superfamily, ARF type | Small_GTPase_ARF | 1 |
IPR024158 | 24,158 | Mitochondrial import protein TIM15 | Mt_import_TIM15 | Family | 5,074 | false | false | Mitochondrial functions rely on the correct transport of resident proteins synthesized in the cytosol to mitochondria. Protein import into mitochondria is mediated by membrane protein complexes, protein translocators, in the outer and inner mitochondrial membranes, in cooperation with their assistant proteins in the cy... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR20922"
] | [
""
] | [
5074
] | 1 | [] | [] | [] | 0 | [
"2e2z"
] | 1 | [
"PUB00017068",
"PUB00047324",
"PUB00055517"
] | [
"15383543",
"17571076",
"15642367"
] | [
"Zim17, a novel zinc finger protein essential for protein import into mitochondria.",
"Structural basis of functional cooperation of Tim15/Zim17 with yeast mitochondrial Hsp70.",
"Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone proteins that facilitates protein trans... | [
2004,
2007,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5074
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
14,
1,
1,
3,
1,
1,
1,
6,
2,
1,
1,
15
] | 12 | true | Family | Mitochondrial import protein TIM15 | Mitochondrial import protein TIM15 | Mt_import_TIM15 | 9 |
IPR024159 | 24,159 | Adaptor protein Cbl, PTB domain | Cbl_PTB | Domain | 4,735 | false | false | Cbl (Casitas B-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface. The N-terminal region of Cbl contains a Cbl-type phosphotyrosine-binding (Cbl-PTB) domain, which is composed of three evolutionarily conserved domains:... | [
"GO:0001784"
] | [
"phosphotyrosine residue binding"
] | [
"molecular_function"
] | 1 | [
"PROFILE"
] | [
"PS51506"
] | [
"CBL_PTB"
] | [
4735
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"2.3.2.27",
"PWY-7511",
"R-DDI-983168",
"R-HSA-1059683",
"R-HSA-1236382",
"R-HSA-1295596",
"R-HSA-1433559",
"R-HSA-182971",
"R-HSA-2173789",
"R-HSA-5637810",
"R-HSA-5654726",
"R-HSA-5654727",
"R-HSA-5654732",
"R-HSA-5654733",
"R-HSA-6807004",
"R-HSA-8849469",
"R-HSA-8856825",
"R-HS... | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-DDI-983168",
"REACTOME:R-HSA-1059683",
"REACTOME:R-HSA-1236382",
"REACTOME:R-HSA-1295596",
"REACTOME:R-HSA-1433559",
"REACTOME:R-HSA-182971",
"REACTOME:R-HSA-2173789",
"REACTOME:R-HSA-5637810",
"REACTOME:R-HSA-5654726",
"REACTOME:R-HSA-5654727",
... | 42 | [
"1b47",
"1fbv",
"1yvh",
"2cbl",
"2y1m",
"2y1n",
"3bum",
"3bun",
"3buo",
"3buw",
"3bux",
"3ob1",
"3ob2",
"3op0",
"3pfv",
"3plf",
"3vgo",
"3vrn",
"3vro",
"3vrp",
"3vrq",
"3vrr",
"3zni",
"4a4b",
"4a4c",
"4gpl",
"5axi",
"5hkw",
"5hkx",
"5hky",
"5hkz",
"5hl0"... | 54 | [
"PUB00019259",
"PUB00055526"
] | [
"10078535",
"18840649"
] | [
"Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.",
"A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling."
] | [
1999,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halalkalicoccus paucihalophilus",
"Viruses"
] | [
14,
4713,
1,
7
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
11,
3,
26,
11,
20
] | 6 | true | Domain | Adaptor protein Cbl, PTB domain | Adaptor protein Cbl, PTB domain | Cbl_PTB | 9 |
IPR024160 | 24,160 | Bin3-type S-adenosyl-L-methionine binding domain | BIN3_SAM-bd_dom | Domain | 4,499 | false | false | null | [
"GO:0008168"
] | [
"methyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PROFILE"
] | [
"PS51515"
] | [
"BIN3_SAM"
] | [
4499
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 147 | [
"5una",
"6dcb",
"6dcc",
"6l8u",
"7slp",
"7slq"
] | 6 | [
"PUB00012883"
] | [
"10717484"
] | [
"Identification of drosophila bicoid-interacting proteins using a custom two-hybrid selection."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Dethiosulfatarculus sandiegensis",
"Eukaryota",
"bird metagenome"
] | [
1,
4497,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
4,
1,
8,
7,
4,
4,
2,
6,
1,
8
] | 10 | true | Domain | Bin3-type S-adenosyl-L-methionine binding domain | Bin3-type S-adenosyl-L-methionine binding domain | BIN3_SAM-bd_dom | 4 |
IPR024161 | 24,161 | Zinc finger, nanos-type | Znf_nanos-typ | Domain | 3,268 | false | false | Nanos is a highly conserved RNA-binding protein in higher eukaryotes and functions as a key regulatory protein in translational control using a 3'untranslated region during the development and maintenance of germ cells. Nanos comprises a non-conserved amino-terminus and highly conserved carboxy-terminal regions. The C-... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF05741",
"PS51522"
] | [
"zf-nanos",
"ZF_NANOS"
] | [
3145,
3226
] | 2 | [
"REACTOME"
] | [
"R-HSA-9827857"
] | [
"REACTOME:R-HSA-9827857"
] | 1 | [
"3alr",
"5kl1",
"5kl8"
] | 3 | [
"PUB00011395",
"PUB00055537",
"PUB00055538"
] | [
"8223259",
"10518502",
"20948543"
] | [
"A mRNA localized to the vegetal cortex of Xenopus oocytes encodes a protein with a nanos-like zinc finger domain.",
"nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans.",
"Crystal structure of zinc-finger domain of Nanos and ... | [
1993,
1999,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Chrysochromulina ericina virus CeV-01B",
"Eukaryota",
"Natronobacterium gregoryi",
"Pseudomonadati",
"metagenomes"
] | [
1,
3212,
2,
3,
50
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
4,
10,
4,
5,
5
] | 6 | true | Domain | Zinc finger, nanos-type | Zinc finger, nanos-type | Znf_nanos-typ | 7 |
IPR024162 | 24,162 | Adaptor protein Cbl | Adaptor_Cbl | Family | 4,781 | false | false | Cbl (Casitas B-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface, including tyrosine kinases, cytokine receptors, and T-cell or B-cell receptors. There are three Cbl related proteins known to date: Cbl, CblB, and CblC... | [
"GO:0004842",
"GO:0023051"
] | [
"ubiquitin-protein transferase activity",
"regulation of signaling"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR23007"
] | [
""
] | [
4781
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"2.3.2.27",
"PWY-7511",
"R-HSA-1059683",
"R-HSA-1236382",
"R-HSA-1295596",
"R-HSA-1433559",
"R-HSA-182971",
"R-HSA-2173789",
"R-HSA-5637810",
"R-HSA-5654726",
"R-HSA-5654727",
"R-HSA-5654732",
"R-HSA-5654733",
"R-HSA-6807004",
"R-HSA-8849469",
"R-HSA-8856825",
"R-HSA-8856828",
"R-H... | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-HSA-1059683",
"REACTOME:R-HSA-1236382",
"REACTOME:R-HSA-1295596",
"REACTOME:R-HSA-1433559",
"REACTOME:R-HSA-182971",
"REACTOME:R-HSA-2173789",
"REACTOME:R-HSA-5637810",
"REACTOME:R-HSA-5654726",
"REACTOME:R-HSA-5654727",
"REACTOME:R-HSA-5654732",
... | 41 | [
"1b47",
"1fbv",
"1yvh",
"2cbl",
"2k4d",
"2ldr",
"2y1m",
"2y1n",
"3bum",
"3bun",
"3buo",
"3buw",
"3bux",
"3ob1",
"3ob2",
"3op0",
"3pfv",
"3plf",
"3vgo",
"3vrn",
"3vro",
"3vrp",
"3vrq",
"3vrr",
"3zni",
"4a49",
"4a4b",
"4a4c",
"4gpl",
"5axi",
"5hkw",
"5hkx"... | 57 | [
"PUB00055539",
"PUB00055540",
"PUB00055541"
] | [
"9824625",
"9653117",
"10393178"
] | [
"A third human CBL gene is on chromosome 19.",
"The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha.",
"The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation."... | [
1998,
1998,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Cas-NS-1 murine leukemia virus",
"Eukaryota"
] | [
1,
4780
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
11,
3,
28,
14,
21
] | 6 | true | Family | Adaptor protein Cbl | Adaptor protein Cbl | Adaptor_Cbl | 3 |
IPR024163 | 24,163 | Aerotolerance regulator, N-terminal | Aerotolerance_reg_N | Domain | 12,158 | false | false | The Batl operon appears to be important in pathogenicity and aerotolerance. BatA ( ) ensures bacterial survival in the early stages of the infection process, when the infected sites are aerobic, and is produced under conditions of oxidative stress [ ]. Proteins produced by the Batl operon share a highly-conserved seque... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07584"
] | [
"BatA"
] | [
12158
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055562",
"PUB00055563"
] | [
"10216867",
"18582330"
] | [
"Characterization of the Batl (Bacteroides aerotolerance) operon in Bacteroides fragilis: isolation of a B. fragilis mutant with reduced aerotolerance and impaired growth in in vivo model systems.",
"Expression patterns of genes induced by oxidative stress in Porphyromonas gingivalis."
] | [
1999,
2008
] | 2 | [] | [
"IPR011933"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
274,
11649,
10,
2,
223
] | 5 | [] | [] | 0 | true | Domain | Aerotolerance regulator, N-terminal | Aerotolerance regulator, N-terminal | Aerotolerance_reg_N | 5 |
IPR024164 | 24,164 | KinB-signalling pathway activation protein | KinB-signalling_activ | Family | 1,483 | false | false | This entry represents a family of proteins involved in the activation of the KinB signaling pathway of sporulation [ ]. | [
"GO:0045881"
] | [
"positive regulation of sporulation resulting in formation of a cellular spore"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PIRSF",
"SMART"
] | [
"PF14089",
"PIRSF029886",
"SM01251"
] | [
"KbaA",
"KBAA",
"KbaA"
] | [
1483,
1205,
1480
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056140"
] | [
"8576055"
] | [
"Identification of a membrane protein involved in activation of the KinB pathway to sporulation in Bacillus subtilis."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
1483
] | 1 | [] | [] | 0 | true | Family | KinB-signalling pathway activation protein | KinB-signalling pathway activation protein | KinB-signalling_activ | 9 |
IPR024165 | 24,165 | Aminoglycoside 3-phosphotransferase | Kan/Strep_kinase | Family | 3,735 | false | false | Aminoglycoside antibiotics constitute an important class of clinically useful drugs, including gentamicin, tobramycin, and streptomycin, which are used in the treatment of a variety of bacterial infections [ ]. They work by targeting the bacterial ribosome and causing mistranslation of mRNA, leading to the production o... | [
"GO:0005524",
"GO:0016773",
"GO:0046677"
] | [
"ATP binding",
"phosphotransferase activity, alcohol group as acceptor",
"response to antibiotic"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF",
"CDD"
] | [
"PIRSF000706",
"cd05150"
] | [
"Kanamycin_kin",
"APH"
] | [
3497,
3637
] | 2 | [
"EC"
] | [
"2.7.1.95"
] | [
"EC:2.7.1.95"
] | 1 | [
"1j7i",
"1j7l",
"1j7u",
"1l8t",
"1nd4",
"2b0q",
"2bkk",
"3q2j",
"3tm0",
"4ej7",
"4feu",
"4fev",
"4few",
"4fex",
"4gkh",
"4gki",
"4h05",
"6fuc",
"6fux"
] | 19 | [
"PUB00014030",
"PUB00026966",
"PUB00027636",
"PUB00033260"
] | [
"11467935",
"12006485",
"12628253",
"9872733"
] | [
"Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase.",
"Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry.",
"The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance.",
"Aminoglyc... | [
2001,
2002,
2003,
1999
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes",
"plasmids"
] | [
3691,
25,
4,
6,
9
] | 5 | [
"Zea mays"
] | [
1
] | 1 | true | Family | Aminoglycoside 3-phosphotransferase | Aminoglycoside 3-phosphotransferase | Kan/Strep_kinase | 7 |
IPR024166 | 24,166 | Ribosomal RNA assembly KRR1 | rRNA_assembly_KRR1 | Family | 5,908 | false | false | This group represents ribosomal RNA assembly protein KRR1, required for 40S ribosome biogenesis. It is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly in Saccharomyces cerevisiae [ , ]. In Schizosaccharomyces pombe it is known as Mis3 [ ]. | [] | [] | [] | 0 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF006515",
"PTHR12581"
] | [
"KRR1",
""
] | [
4113,
5908
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6791226",
"R-DDI-6791226",
"R-DME-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-BTA-6791226",
"REACTOME:R-DDI-6791226",
"REACTOME:R-DME-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 8 | [
"4qmf",
"5jpq",
"5oql",
"5wlc",
"5wyj",
"5wyk",
"6ke6",
"6lqp",
"6lqq",
"6lqu",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"7ajt",
"7d5s",
"7mq8",
"7mq9",
"7suk",
"9g25",
"9g28",
"9g33",
"9n6v",
"9n6w",
"9n6x",
"9n6y",
"9n6z"... | 32 | [
"PUB00055620",
"PUB00055621",
"PUB00055622"
] | [
"11996121",
"15094838",
"10947840"
] | [
"The KRR1 gene encodes a protein required for 18S rRNA synthesis and 40S ribosomal subunit assembly in Saccharomyces cerevisiae.",
"Functional and physical interactions of Krr1p, a Saccharomyces cerevisiae nucleolar protein.",
"Mis3 with a conserved RNA binding motif is essential for ribosome biogenesis and imp... | [
2000,
2004,
2000
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5908
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
1,
1,
2,
3,
1,
7,
5,
1,
1,
13
] | 12 | true | Family | Ribosomal RNA assembly KRR1 | Ribosomal RNA assembly KRR1 | rRNA_assembly_KRR1 | 9 |
IPR024167 | 24,167 | Cytochrome c4-like | Cytochrome_c4-like | Family | 8,546 | false | false | This group represents cytochrome c4. It is a di-heme, high potential cytochrome c believed to be an intermediate electron donor in an anaerobic electron transport chain [ ]. | [
"GO:0005506",
"GO:0009055",
"GO:0020037",
"GO:0042597"
] | [
"iron ion binding",
"electron transfer activity",
"heme binding",
"periplasmic space"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF000005"
] | [
"Cytochrome_c4"
] | [
8546
] | 1 | [] | [] | [] | 0 | [
"1etp",
"1fcd",
"1h1o",
"1m6z",
"1m70",
"3vrd",
"6q2u",
"8smr",
"8snh",
"8uf3"
] | 10 | [
"PUB00055613"
] | [
"17931594"
] | [
"Oxygen and temperature-dependent structural and redox changes in a novel cytochrome c(4) from the purple sulfur photosynthetic bacterium Thiocapsa roseopersicina."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
8393,
8,
145
] | 3 | [] | [] | 0 | true | Family | Cytochrome c4-like | Cytochrome c4-like | Cytochrome_c4-like | 5 |
IPR024168 | 24,168 | Catalase, SrpA-type, predicted | Catalase_SrpA-type_pred | Family | 3,619 | false | false | Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes involved in the protection of cells from the toxic effects of peroxides. It catalyses the conversion of hydrogen peroxide to water and molecular oxygen. Several other related protein families share the catalase fold and bind to heme but do not nec... | [] | [] | [] | 0 | [
"PIRSF",
"CDD"
] | [
"PIRSF000296",
"cd08153"
] | [
"SrpA",
"srpA_like"
] | [
3500,
3403
] | 2 | [] | [] | [] | 0 | [
"3e4w",
"3e4y"
] | 2 | [
"PUB00055612"
] | [
"20520822"
] | [
"The monofunctional catalase KatE of Xanthomonas axonopodis pv. citri is required for full virulence in citrus plants."
] | [
2010
] | 1 | [
"IPR018028"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanosarcina",
"unclassified sequences"
] | [
3112,
492,
10,
5
] | 4 | [] | [] | 0 | true | Family | Catalase, SrpA-type, predicted | Catalase, SrpA-type, predicted | Catalase_SrpA-type_pred | 6 |
IPR024169 | 24,169 | Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase | SP_NH2Trfase/AEP_transaminase | Family | 24,765 | false | false | This entry represents a group of class-V pyridoxal-phosphate-dependent aminotransferases, and includes serine pyruvate aminotransferase [ , ] and 2-aminoethylphosphonate-pyruvate transaminase [ ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF000524"
] | [
"SPT"
] | [
24765
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.6.1",
"2.6.1.37",
"PWY-6832",
"PWY-6839",
"R-DDI-389661",
"R-DDI-9033241",
"R-DME-389661",
"R-DME-9033241",
"R-HSA-389661",
"R-HSA-9033241",
"R-MMU-389661",
"R-MMU-9033241",
"R-RNO-389661",
"R-RNO-9033241"
] | [
"EC:2.6.1",
"EC:2.6.1.37",
"METACYC:PWY-6832",
"METACYC:PWY-6839",
"REACTOME:R-DDI-389661",
"REACTOME:R-DDI-9033241",
"REACTOME:R-DME-389661",
"REACTOME:R-DME-9033241",
"REACTOME:R-HSA-389661",
"REACTOME:R-HSA-9033241",
"REACTOME:R-MMU-389661",
"REACTOME:R-MMU-9033241",
"REACTOME:R-RNO-38966... | 14 | [
"1h0c",
"1iug",
"1j04",
"1m32",
"1vjo",
"2bkw",
"2ch1",
"2ch2",
"2dr1",
"2huf",
"2hui",
"2huu",
"2yob",
"2yri",
"2yrr",
"2z9u",
"2z9v",
"2z9w",
"2z9x",
"3f0h",
"3isl",
"3ke3",
"3kgw",
"3kgx",
"3nnk",
"3r9a",
"3zrp",
"3zrq",
"3zrr",
"4cbr",
"4cbs",
"4i8a"... | 46 | [
"PUB00002257",
"PUB00027921",
"PUB00055615"
] | [
"7961516",
"8144463",
"6406228"
] | [
"Genetics of the serine cycle in Methylobacterium extorquens AM1: identification, sequence, and mutation of three new genes involved in C1 assimilation, orf4, mtkA, and mtkB.",
"Genetics of the serine cycle in Methylobacterium extorquens AM1: identification of sgaA and mtdA and sequences of sgaA, hprA, and mtdA."... | [
1994,
1994,
1983
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviricetes",
"unclassified sequences"
] | [
1429,
18911,
4134,
2,
289
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
3,
1,
2,
1,
4,
2,
3,
4,
1,
5
] | 10 | true | Family | Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase | Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase | SP_NH2Trfase/AEP_transaminase | 8 |
IPR024170 | 24,170 | Aminoglycoside N6-acetyltransferase | Aminoglycoside_N6-AcTrfrase | Family | 1,637 | false | false | Aminoglycoside N6'-acetyltransferase [ ] is a antibiotic resistance protein that catalyses the reaction: acetyl-CoA + kanamycin-B = CoA + N(6')-acetylkanamycin-B | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF000452"
] | [
"6-N-acetyltransf"
] | [
1637
] | 1 | [
"EC"
] | [
"2.3.1.82"
] | [
"EC:2.3.1.82"
] | 1 | [
"1s3z",
"1s5k",
"1s60",
"2vbq",
"4e8o",
"4evy",
"4f0y"
] | 7 | [
"PUB00023545"
] | [
"10378269"
] | [
"Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
1634,
3
] | 2 | [] | [] | 0 | true | Family | Aminoglycoside N6-acetyltransferase | Aminoglycoside N6-acetyltransferase | Aminoglycoside_N6-AcTrfrase | 4 |
IPR024172 | 24,172 | Adenylyltransferase AadA/Aad9 | AadA/Aad9 | Family | 2,954 | false | false | This family includes aminoglycoside (3'') (9) adenylyltransferase AadA and spectinomycin 9-adenylyltransferase Aad9. AadA mediates bacterial resistance to the antibiotics streptomycin and spectinomycin [ , ], while Aad9 mediates bacterial resistance to the antibiotic spectinomycin [ ]. | [
"GO:0070566",
"GO:0046677"
] | [
"adenylyltransferase activity",
"response to antibiotic"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF000819"
] | [
"Streptomycin_3-adenylyltransf"
] | [
2954
] | 1 | [] | [] | [] | 0 | [
"4cs6",
"5g4a",
"5lpa",
"5luh",
"6fzb",
"7uy4"
] | 6 | [
"PUB00055619",
"PUB00094230",
"PUB00094231"
] | [
"2986186",
"2993813",
"2997737"
] | [
"Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenylyltransferase.",
"Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3\") (9).",
"Nucleotide sequence of the transposon Tn7 gene encoding an aminogl... | [
1985,
1985,
1985
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Palaeococcus pacificus DY20341",
"Punavirus P1",
"plasmids",
"unclassified sequences"
] | [
2938,
4,
1,
2,
2,
7
] | 6 | [] | [] | 0 | true | Family | Adenylyltransferase AadA/Aad9 | Adenylyltransferase AadA/Aad9 | AadA/Aad9 | 4 |
IPR024173 | 24,173 | Phosphoesterase MJ0037-like | Pesterase_MJ0037-like | Family | 6,431 | false | false | This group of conserved proteins from bacteria and archaea contain one copy of the calcineurin-like phosphoesterase domain ( ) and possess motifs characteristic of a variety of enzymatically active phosphoesterases [ ], including acid and alkaline phosphatases, phosphoprotein phosphatases, 5'-nucleotidase, bis(5'-nucle... | [] | [] | [] | 0 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF000887",
"PTHR39323"
] | [
"Pesterase_MJ0037",
""
] | [
5826,
6431
] | 2 | [] | [] | [] | 0 | [
"6nvo",
"6nvp"
] | 2 | [
"PUB00014394"
] | [
"8683579"
] | [
"Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures."
] | [
1996
] | 1 | [] | [
"IPR004376",
"IPR026336"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1250,
5120,
7,
54
] | 4 | [] | [] | 0 | true | Family | Phosphoesterase MJ0037-like | Phosphoesterase MJ0037-like | Pesterase_MJ0037-like | 2 |
IPR024174 | 24,174 | Hepatocyte growth factor/Macrophage stimulatory protein | HGF/MST1 | Family | 2,552 | false | false | This entry includes hepatocyte growth factor (HGF; also called scatter factor) and HGF-like proteins (also known as macrophage stimulatory protein, MST1). Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regen... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF001152"
] | [
"HGF_MST1"
] | [
2552
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CFA-114608",
"R-CFA-1257604",
"R-CFA-5673001",
"R-CFA-6806942",
"R-CFA-6807004",
"R-CFA-6811558",
"R-CFA-8851805",
"R-CFA-8851907",
"R-CFA-8865999",
"R-CFA-8874081",
"R-CFA-8875513",
"R-CFA-8875555",
"R-CFA-8875656",
"R-CFA-8875791",
"R-CFA-9734091",
"R-HSA-114608",
"R-HSA-1257604... | [
"REACTOME:R-CFA-114608",
"REACTOME:R-CFA-1257604",
"REACTOME:R-CFA-5673001",
"REACTOME:R-CFA-6806942",
"REACTOME:R-CFA-6807004",
"REACTOME:R-CFA-6811558",
"REACTOME:R-CFA-8851805",
"REACTOME:R-CFA-8851907",
"REACTOME:R-CFA-8865999",
"REACTOME:R-CFA-8874081",
"REACTOME:R-CFA-8875513",
"REACTOME... | 65 | [
"7mo7",
"7mo8",
"7mo9",
"7moa"
] | 4 | [
"PUB00054731"
] | [
"20624990"
] | [
"Structural basis for agonism and antagonism of hepatocyte growth factor."
] | [
2010
] | 1 | [
"IPR001314"
] | [
"IPR027284",
"IPR043575"
] | 1 | 2 | 0 | [
"Chordata"
] | [
2552
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
7,
6,
10
] | 4 | true | Family | Hepatocyte growth factor/Macrophage stimulatory protein | Hepatocyte growth factor/Macrophage stimulatory protein | HGF/MST1 | 6 |
IPR024175 | 24,175 | Peptidase S1A, complement C1r/C1S/mannan-binding | Pept_S1A_C1r/C1S/mannan-bd | Family | 3,808 | false | false | These proteins belong to MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)), subfamily S1A. This family contains the mammalian mannan-binding lectin-associated serine proteases 1 and 2 (MASP1 and MASP2) and complement components C1s and C1r. The C1 complex, containing C1q, C1s, and C1r, triggers the classical... | [
"GO:0004252",
"GO:0006956",
"GO:0005576"
] | [
"serine-type endopeptidase activity",
"complement activation",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF"
] | [
"PIRSF001155"
] | [
"C1r_C1s_MASP"
] | [
3808
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.21",
"R-HSA-166662",
"R-HSA-166663",
"R-HSA-173623",
"R-HSA-2855086",
"R-HSA-3000480",
"R-HSA-9705671",
"R-HSA-977606",
"R-MMU-166662",
"R-MMU-166663",
"R-MMU-173623",
"R-MMU-2855086",
"R-MMU-3000480",
"R-MMU-977606",
"R-RNO-166662",
"R-RNO-166663",
"R-RNO-173623",
"R-RNO-2855... | [
"EC:3.4.21",
"REACTOME:R-HSA-166662",
"REACTOME:R-HSA-166663",
"REACTOME:R-HSA-173623",
"REACTOME:R-HSA-2855086",
"REACTOME:R-HSA-3000480",
"REACTOME:R-HSA-9705671",
"REACTOME:R-HSA-977606",
"REACTOME:R-MMU-166662",
"REACTOME:R-MMU-166663",
"REACTOME:R-MMU-173623",
"REACTOME:R-MMU-2855086",
... | 19 | [] | 0 | [
"PUB00014578",
"PUB00014579",
"PUB00100783"
] | [
"10946292",
"10475605",
"21258343"
] | [
"Proteolytic activities of two types of mannose-binding lectin-associated serine protease.",
"Gene structure of the P100 serine-protease component of the human Ra-reactive factor.",
"Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome."
] | [
2000,
1999,
2011
] | 3 | [
"IPR001314"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
3808
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
18,
11,
17
] | 4 | true | Family | Peptidase S1A, complement C1r/C1S/mannan-binding | Peptidase S1A, complement C1r/C1S/mannan-binding | Pept_S1A_C1r/C1S/mannan-bd | 8 |
IPR024176 | 24,176 | Citrate synthase, bacterial-type | Citrate_synthase_bac-typ | Family | 33,051 | false | false | Citrate synthase is a member of a small family of enzymes that can directly form a carbon-carbon bond without the presence of metal ion cofactors. It catalyses the first reaction in the Krebs' cycle, namely the conversion of oxaloacetate and acetyl-coenzyme A into citrate and coenzyme A. This reaction is important for ... | [
"GO:0046912",
"GO:0006099"
] | [
"acyltransferase activity, acyl groups converted into alkyl on transfer",
"tricarboxylic acid cycle"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF001369"
] | [
"Citrate_synth"
] | [
33051
] | 1 | [
"EC",
"EC"
] | [
"2.3.3",
"2.3.3.16"
] | [
"EC:2.3.3",
"EC:2.3.3.16"
] | 2 | [
"1a59",
"1aj8",
"1iom",
"1ixe",
"1nxe",
"1nxg",
"1o7x",
"1owb",
"1owc",
"1vgm",
"1vgp",
"2c6x",
"2h12",
"2ibp",
"2ifc",
"2p2w",
"2r26",
"2r9e",
"3hwk",
"3msu",
"3o8j",
"3tqg",
"4e6y",
"4g6b",
"4jad",
"4jae",
"4jaf",
"4jag",
"4tvm",
"4xgh",
"4ybo",
"6abv"... | 45 | [
"PUB00013490",
"PUB00033360",
"PUB00042604",
"PUB00042605",
"PUB00090961"
] | [
"9579066",
"8759838",
"15147839",
"17087502",
"28956599"
] | [
"Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships.",
"A sigma E dependent operon subject to catabolite repression during sporulation in Bacillus subtilis.",
"Investigating the accessibility of the closed domain conformation of citrate synthase using essential ... | [
1998,
1996,
2004,
2006,
2017
] | 5 | [
"IPR002020"
] | [
"IPR010953",
"IPR011278"
] | 1 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
712,
31134,
844,
361
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
2,
1,
3
] | 4 | true | Family | Citrate synthase, bacterial-type | Citrate synthase, bacterial-type | Citrate_synthase_bac-typ | 4 |
IPR024178 | 24,178 | Estrogen receptor/oestrogen-related receptor | Est_rcpt/est-rel_rcp | Family | 7,035 | false | false | Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and r... | [
"GO:0003677",
"GO:0003707",
"GO:0005496",
"GO:0008270",
"GO:0006355",
"GO:0005634"
] | [
"DNA binding",
"nuclear steroid receptor activity",
"steroid binding",
"zinc ion binding",
"regulation of DNA-templated transcription",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 6 | [
"PIRSF"
] | [
"PIRSF002527"
] | [
"ER-like_NR"
] | [
7035
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1251985",
"R-BTA-1257604",
"R-BTA-383280",
"R-BTA-4090294",
"R-BTA-5689896",
"R-BTA-6811558",
"R-BTA-8866910",
"R-BTA-8931987",
"R-BTA-8939211",
"R-BTA-9009391",
"R-BTA-9018519",
"R-BTA-9841251",
"R-DRE-1251985",
"R-DRE-1257604",
"R-DRE-5689896",
"R-DRE-6811558",
"R-DRE-893921... | [
"REACTOME:R-BTA-1251985",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-383280",
"REACTOME:R-BTA-4090294",
"REACTOME:R-BTA-5689896",
"REACTOME:R-BTA-6811558",
"REACTOME:R-BTA-8866910",
"REACTOME:R-BTA-8931987",
"REACTOME:R-BTA-8939211",
"REACTOME:R-BTA-9009391",
"REACTOME:R-BTA-9018519",
"REACTOME... | 73 | [] | 0 | [
"PUB00004464",
"PUB00006168",
"PUB00015853",
"PUB00054107",
"PUB00055623"
] | [
"7899080",
"8165128",
"14747695",
"10219237",
"12185669"
] | [
"Vitamin D receptor contains multiple dimerization interfaces that are functionally different.",
"Human androgen receptor expressed in HeLa cells activates transcription in vitro.",
"Nuclear receptors: the evolution of diversity.",
"A unified nomenclature system for the nuclear receptor superfamily.",
"To E... | [
1995,
1994,
2004,
1999,
2002
] | 5 | [
"IPR001723"
] | [
"IPR001292",
"IPR027289",
"IPR028355"
] | 1 | 3 | 0 | [
"Bilateria"
] | [
7035
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
56,
2,
31,
14,
35
] | 5 | true | Family | Estrogen receptor/oestrogen-related receptor | Estrogen receptor/oestrogen-related receptor | Est_rcpt/est-rel_rcp | 1 |
IPR024180 | 24,180 | Bifunctional tetrapyrrole methylase/MazG NTP pyrophosphohydrolase, predicted | Tetrapyrrole_Mease/MazG_pred | Family | 2,234 | false | false | The proteins in this entry are uncharacterised but contain an N-terminal tetrapyrole methylase domain and a C-terminal MazG-type NTP pyrophosphohydrolase domain. On this basis they are predicted to be bifunctional tetrapyrole methylase/NTP pyrophosphohydrolases. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF002845"
] | [
"Ttrprl_mtas_MazG"
] | [
2234
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR011551"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Phytophthora kernoviae 00238/432",
"metagenomes"
] | [
2228,
1,
5
] | 3 | [] | [] | 0 | true | Family | Bifunctional tetrapyrrole methylase/MazG NTP pyrophosphohydrolase, predicted | Bifunctional tetrapyrrole methylase/MazG NTP pyrophosphohydrolase, predicted | Tetrapyrrole_Mease/MazG_pred | 3 |
IPR024181 | 24,181 | Chemotaxis response regulator CheV | Chemotax_regulator_CheV | Family | 9,083 | false | false | This group contains chemotaxis response regulator protein CheV. CheV is a two-domain protein with an N-terminal CheW-like (SH3-like) domain and a C-terminal CheY-like receiver domain. It is often regarded as a version of CheW, where the CheW-like domain is fused to the receiver domain. In bacterial chemotaxis, cellular... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF002867"
] | [
"CheV"
] | [
9083
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011107",
"PUB00018324",
"PUB00027751",
"PUB00027767",
"PUB00027785",
"PUB00027795",
"PUB00093704"
] | [
"10049806",
"11553614",
"15203024",
"12011495",
"11535789",
"8169224",
"19332820"
] | [
"Structural analysis of bacterial chemotaxis proteins: components of a dynamic signaling system.",
"Phosphorylation of the response regulator CheV is required for adaptation to attractants during Bacillus subtilis chemotaxis.",
"Bacterial chemosensing: cooperative molecular logic.",
"Information processing in... | [
1998,
2001,
2004,
2002,
2001,
1994,
2009
] | 7 | [] | [] | 0 | 0 | null | [
"Bacillus thuringiensis phage MZTP02",
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
1,
8995,
2,
85
] | 4 | [] | [] | 0 | true | Family | Chemotaxis response regulator CheV | Chemotaxis response regulator CheV | Chemotax_regulator_CheV | 9 |
IPR024182 | 24,182 | Vaccinia virus A55R | Vaccinia_A55R | Family | 188 | false | false | This family includes ORF A55R from Vaccinia virus, which is characterised by having a BTB (for BR-C, ttk and bab) [ ] or POZ (for Pox virus and Zinc finger) [ ] domain near the N terminus. The proteins are also characterised by kelch repeats C-terminal to the BTB domain. The function of these proteins are unknown. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF003716"
] | [
"VAC_F3L"
] | [
188
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001918",
"PUB00004829"
] | [
"7958847",
"7938017"
] | [
"The POZ domain: a conserved protein-protein interaction motif.",
"The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila."
] | [
1994,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Chordopoxvirinae"
] | [
188
] | 1 | [] | [] | 0 | true | Family | Vaccinia virus A55R | Vaccinia virus A55R | Vaccinia_A55R | 5 |
IPR024183 | 24,183 | RING finger protein Z, arenaviridae | RING_finger_Z_arenaviridae | Family | 586 | false | false | Arenaviridae produce four gene products: RNA-directed RNA polymerase, Z (zinc finger) protein, nucleocapsid protein (NP), and envelope glycoprotein precursor (which gives rise to mature proteins GP1 and GP2). The smallest protein is the Z protein (also called p11), which has molecular size of 11 kD. The Z protein has a... | [
"GO:0046761"
] | [
"viral budding from plasma membrane"
] | [
"biological_process"
] | 1 | [
"HAMAP",
"PIRSF"
] | [
"MF_04087",
"PIRSF004030"
] | [
"ARENA_Z",
"Z_ArenaV"
] | [
526,
583
] | 2 | [] | [] | [] | 0 | [
"2m1s",
"7ckl",
"7ckm",
"7eju",
"7el9",
"7ela",
"7elb",
"7elc",
"7vgq",
"7vh1",
"7x6v"
] | 11 | [
"PUB00055573",
"PUB00055574",
"PUB00055575"
] | [
"15452271",
"14563923",
"1626415"
] | [
"Myristoylation of the RING finger Z protein is essential for arenavirus budding.",
"The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies.",
"Biochemical and immunological evidence that the 11 kDa zinc-binding protein of lymphocytic choriomeningitis virus is a structu... | [
2004,
2003,
1992
] | 3 | [] | [] | 0 | 0 | null | [
"Arenaviridae"
] | [
586
] | 1 | [] | [] | 0 | true | Family | RING finger protein Z, arenaviridae | RING finger protein Z, arenaviridae | RING_finger_Z_arenaviridae | 7 |
IPR024184 | 24,184 | Uncharacterised conserved protein UCP005637 | UCP005637 | Family | 19 | false | false | There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF005637"
] | [
"UCP005637"
] | [
19
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160784"
] | [
"38748582"
] | [
"YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of <i>Escherichia coli</i>."
] | [
2024
] | 1 | [
"IPR019296"
] | [] | 1 | 0 | 1 | [
"Methanomada group"
] | [
19
] | 1 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP005637 | Uncharacterised conserved protein UCP005637 | UCP005637 | 2 |
IPR024185 | 24,185 | 5-formyltetrahydrofolate cyclo-ligase-like domain superfamily | FTHF_cligase-like_sf | Homologous_superfamily | 59,046 | false | false | This superfamily represents a domain found in 5-formyltetrahydrofolate cyclo-ligase, also known as 5,10-methenyltetrahydrofolate synthetase. This enzyme is involved in folate metabolism. It is a single-domain alpha/beta protein. The central core of the protein is a four-stranded parallel β-strand flanked by three helic... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:3.40.50.10420"
] | [
""
] | [
59046
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-196757",
"R-HSA-196757",
"R-MMU-196757",
"R-SCE-196757",
"R-SPO-196757"
] | [
"REACTOME:R-CEL-196757",
"REACTOME:R-HSA-196757",
"REACTOME:R-MMU-196757",
"REACTOME:R-SCE-196757",
"REACTOME:R-SPO-196757"
] | 5 | [
"1sbq",
"1sou",
"1u3f",
"1u3g",
"1wkc",
"1ydm",
"2g40",
"2jcb",
"3hxt",
"3hy3",
"3hy4",
"3hy6"
] | 12 | [
"PUB00030982",
"PUB00053899"
] | [
"15281135",
"19201793"
] | [
"Crystal structure of methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087) at 2.2 A resolution.",
"A widely conserved gene cluster required for lactate utilization in Bacillus subtilis and its involvement in biofilm formation."
] | [
2004,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimivirus LCMiAC02",
"unclassified sequences"
] | [
1744,
49278,
7308,
1,
715
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
10,
1,
8,
5,
3,
13,
10,
1,
11,
12,
1,
1,
12
] | 13 | true | Homologous_superfamily | 5-formyltetrahydrofolate cyclo-ligase-like domain superfamily | 5-formyltetrahydrofolate cyclo-ligase-like domain superfamily | FTHF_cligase-like_sf | 8 |
IPR024186 | 24,186 | Signal transduction response regulator, heterocyst pattern formation, PatA | Sig_transdc_resp-reg_PatA | Family | 1,016 | false | false | This group contains response regulators involved in the control of heterocyst pattern formation. Heterocysts are microaerobic, N 2 -fixing cells that form in a patterned array within O 2 -producing filamentous cyanobacteria [ ]. PatA plays a role in controlling the differentiation process that produces heterocysts [ , ... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF005897"
] | [
"RR_PatA"
] | [
1016
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007866",
"PUB00011096",
"PUB00011157",
"PUB00011190",
"PUB00014606",
"PUB00014607",
"PUB00014608"
] | [
"11406410",
"10966457",
"10622255",
"10500846",
"8982449",
"11226308",
"1608976"
] | [
"Histidine kinases and response regulator proteins in two-component signaling systems.",
"Two-component signal transduction.",
"Structure of a transiently phosphorylated switch in bacterial signal transduction.",
"The histidine protein kinase superfamily.",
"Heterocyst formation.",
"Expression of the Anab... | [
2001,
2000,
1999,
1999,
1996,
2001,
1992
] | 7 | [] | [] | 0 | 0 | null | [
"Cyanobacteriota"
] | [
1016
] | 1 | [] | [] | 0 | true | Family | Signal transduction response regulator, heterocyst pattern formation, PatA | Signal transduction response regulator, heterocyst pattern formation, PatA | Sig_transdc_resp-reg_PatA | 3 |
IPR024187 | 24,187 | Signal transduction response regulator, citrate/malate metabolism | Sig_transdc_resp-reg_cit/mal | Family | 12,641 | false | false | Members of this group are response regulators containing CheY-like receiver and HTH (helix-turn-helix) DNA-binding domains. Several members of this group have been characterised as response regulators controlling the genes involved in metabolism of citrate or C4-dicarboxylates (aspartate, fumarate, malate, and succinat... | [
"GO:0003700",
"GO:0000160"
] | [
"DNA-binding transcription factor activity",
"phosphorelay signal transduction system"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF006171"
] | [
"RR_citrat_malat"
] | [
12641
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007866",
"PUB00011096",
"PUB00011097",
"PUB00011100",
"PUB00011101",
"PUB00011102",
"PUB00011103",
"PUB00011104",
"PUB00011105",
"PUB00011106"
] | [
"11406410",
"10966457",
"11851334",
"8218244",
"9223636",
"9765574",
"9701802",
"8831795",
"11179888",
"9133329"
] | [
"Histidine kinases and response regulator proteins in two-component signaling systems.",
"Two-component signal transduction.",
"Dimer formation and transcription activation in the sporulation response regulator Spo0A.",
"Structural conservation in the CheY superfamily.",
"In vitro binding of the response re... | [
2001,
2000,
2002,
1993,
1997,
1998,
1998,
1996,
2001,
1997
] | 10 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
12604,
3,
34
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Signal transduction response regulator, citrate/malate metabolism | Signal transduction response regulator, citrate/malate metabolism | Sig_transdc_resp-reg_cit/mal | 3 |
IPR024188 | 24,188 | Glutamate synthase large subunit-like protein | GltB | Family | 12,651 | false | false | Glutamate synthase (GOGAT, GltS) is a complex iron-sulphur flavoprotein that catalyses the reductive synthesis of L-glutamate from 2-oxoglutarate (2-OG) and L-glutamine via intramolecular channeling of ammonia, a reaction in the bacterial, yeast and plant pathways for ammonia assimilation [ ]. GOGAT is a multifunctiona... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF006429"
] | [
"GOGAT_lg_2"
] | [
12651
] | 1 | [
"EC"
] | [
"1.4.1.13"
] | [
"EC:1.4.1.13"
] | 1 | [] | 0 | [
"PUB00008698",
"PUB00009386",
"PUB00013982",
"PUB00015710"
] | [
"11967268",
"10357231",
"11188694",
"11230537"
] | [
"Structural studies on the synchronization of catalytic centers in glutamate synthase.",
"Glutamate synthase: a complex iron-sulfur flavoprotein.",
"Cross-talk and ammonia channeling between active centers in the unexpected domain arrangement of glutamate synthase.",
"Phylogenetic analyses of two \"archaeal\"... | [
2002,
1999,
2000,
2001
] | 4 | [] | [
"IPR027283",
"IPR043578"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
452,
11945,
32,
222
] | 4 | [] | [] | 0 | true | Family | Glutamate synthase large subunit-like protein | Glutamate synthase large subunit-like protein | GltB | 6 |
IPR024189 | 24,189 | ANTAR transcription anti-termination regulator | ANTAR_transcrpt_antiterm_reg | Family | 431 | false | false | This group represents the stand-alone version of an RNA-binding ANTAR domain (AmiR-like) that affects anti-termination [ , , ]. This domain is most often found fused to the CheY-like receiver domain to form response regulator anti-terminator ( ). Superficially, the coiled-coil and three-helix bundle that form this doma... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF010636"
] | [
"ANTAR_solo"
] | [
431
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011096",
"PUB00011191",
"PUB00011193",
"PUB00011194"
] | [
"10966457",
"10508151",
"11796212",
"8918468"
] | [
"Two-component signal transduction.",
"Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex.",
"ANTAR: an RNA-binding domain in transcription antitermination regulatory proteins.",
"Transcription antitermination regulation of the Pseudomonas aerugino... | [
2000,
1999,
2002,
1996
] | 4 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
431
] | 1 | [] | [] | 0 | true | Family | ANTAR transcription anti-termination regulator | ANTAR transcription anti-termination regulator | ANTAR_transcrpt_antiterm_reg | 3 |
IPR024190 | 24,190 | Methenyltetrahydromethanopterin dehydrogenase, Hmd-type | METHMP_Hmd | Family | 132 | false | false | The N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase system of methanogenic archaea is composed of H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd, , this group) and F420-dependent methylenetetrahydromethanopterin dehydrogenase [ , ] ( ). Hmd is an iron-sulphur-cluster-free enzyme that contains ... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF016158"
] | [
"HMD"
] | [
132
] | 1 | [
"EC",
"METACYC"
] | [
"1.12.98.2",
"PWY-7784"
] | [
"EC:1.12.98.2",
"METACYC:PWY-7784"
] | 2 | [
"2b0j",
"3daf",
"3dag",
"3f46",
"3f47",
"3h65",
"4jjf",
"4jjg",
"4yt2",
"4yt4",
"4yt5",
"4yt8",
"5ok4",
"6ggu",
"6hac",
"6hae",
"6hav",
"6hux",
"6yk9",
"6yka",
"6ykb"
] | 21 | [
"PUB00013473",
"PUB00014603",
"PUB00014604",
"PUB00014605",
"PUB00016833"
] | [
"11081790",
"9477254",
"8215796",
"9151968",
"15506791"
] | [
"Regulation of the synthesis of H2-forming methylenetetrahydromethanopterin dehydrogenase (Hmd) and of HmdII and HmdIII in Methanothermobacter marburgensis.",
"Function of H2-forming methylenetetrahydromethanopterin dehydrogenase from methanobacterium thermoautotrophicum in coenzyme F420 reduction with H2",
"Tw... | [
2000,
1998,
1993,
1997,
2004
] | 5 | [] | [
"IPR010062",
"IPR010063"
] | 0 | 2 | 0 | [
"Methanobacteriota",
"bioreactor metagenome"
] | [
131,
1
] | 2 | [] | [] | 0 | true | Family | Methenyltetrahydromethanopterin dehydrogenase, Hmd-type | Methenyltetrahydromethanopterin dehydrogenase, Hmd-type | METHMP_Hmd | 3 |
IPR024191 | 24,191 | Peptidase M61 | Peptidase_M61 | Family | 6,345 | false | false | Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF016493"
] | [
"Glycyl_aminpptds"
] | [
6345
] | 1 | [] | [] | [] | 0 | [
"4fgm",
"8j9c",
"8j9d"
] | 3 | [
"PUB00003579"
] | [
"7674922"
] | [
"Evolutionary families of metallopeptidases."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
50,
6243,
7,
45
] | 4 | [] | [] | 0 | true | Family | Peptidase M61 | Peptidase M61 | Peptidase_M61 | 6 |
IPR024192 | 24,192 | Fosfomycin resistance kinase, FomA-type | Fosfomycin_R_FomA-type | Family | 1,837 | false | false | This entry represents a group of isopentenyl phosphate kinases (IPKs) from archaea and plants. They catalyze the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids [ , ]. This entry also includes FomA protein from Streptomyces. IPKs and FomA are architecturally very similar [ ]. Fosfomyci... | [
"GO:0016301"
] | [
"kinase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM",
"PIRSF",
"CDD"
] | [
"NF040647",
"PIRSF016496",
"cd04241"
] | [
"IPPK_Arch",
"Kin_FomA",
"AAK_FomA-like"
] | [
1768,
1574,
1363
] | 3 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.4.26",
"PWY-6174",
"PWY-7524",
"PWY-8125"
] | [
"EC:2.7.4.26",
"METACYC:PWY-6174",
"METACYC:PWY-7524",
"METACYC:PWY-8125"
] | 4 | [
"3d40",
"3d41",
"3k4o",
"3k4y",
"3k52",
"3k56",
"3lkk",
"3ll5",
"3ll9",
"3qun",
"3quo",
"3qur",
"3qvf",
"3qvh",
"7lnt",
"7lnu",
"7lnv",
"7lnw",
"7lnx",
"7n9d",
"8u0k",
"8u0l",
"8u0m",
"8u0n"
] | 24 | [
"PUB00014686",
"PUB00073601",
"PUB00101688",
"PUB00101689",
"PUB00105873"
] | [
"10681332",
"19928876",
"26216978",
"20392112",
"16621811"
] | [
"Characterization of the fomA and fomB gene products from Streptomyces wedmorensis, which confer fosfomycin resistance on Escherichia coli.",
"Characterization of thermophilic archaeal isopentenyl phosphate kinases.",
"Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plant... | [
2000,
2010,
2015,
2010,
2006
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
876,
181,
744,
36
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
2,
3
] | 3 | true | Family | Fosfomycin resistance kinase, FomA-type | Fosfomycin resistance kinase, FomA-type | Fosfomycin_R_FomA-type | 6 |
IPR024193 | 24,193 | Ku80 | Ku80 | Family | 4,260 | false | false | This group consists of eukaryotic proteins containing the Ku80 domain. In eukaryotes it has been shown that Ku protein is involved in repairing DNA double-strand breaks by non-homologous end-joining [ , , ]. Ku is a heterodimer of approximately 70kDa and 80kDa subunits [ ]. Both these subunits have strong sequence simi... | [
"GO:0003677",
"GO:0003684",
"GO:0042162",
"GO:0000723",
"GO:0006303",
"GO:0006310",
"GO:0005634",
"GO:0043564"
] | [
"DNA binding",
"damaged DNA binding",
"telomeric DNA binding",
"telomere maintenance",
"double-strand break repair via nonhomologous end joining",
"DNA recombination",
"nucleus",
"Ku70:Ku80 complex"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"cellular_component",
"cellular_component"
] | 8 | [
"PIRSF",
"CDD"
] | [
"PIRSF016570",
"cd00873"
] | [
"Ku80",
"KU80"
] | [
2689,
4253
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.4.12",
"R-DDI-5693571",
"R-DDI-6798695",
"R-HSA-164843",
"R-HSA-1834949",
"R-HSA-3270619",
"R-HSA-5693571",
"R-HSA-6798695",
"R-MMU-5693571",
"R-MMU-6798695",
"R-SCE-6798695",
"R-SPO-6798695"
] | [
"EC:3.6.4.12",
"REACTOME:R-DDI-5693571",
"REACTOME:R-DDI-6798695",
"REACTOME:R-HSA-164843",
"REACTOME:R-HSA-1834949",
"REACTOME:R-HSA-3270619",
"REACTOME:R-HSA-5693571",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-5693571",
"REACTOME:R-MMU-6798695",
"REACTOME:R-SCE-6798695",
"REACTOME:R-SPO-6798... | 12 | [
"1jeq",
"1jey",
"5y3r",
"5y58",
"6erf",
"6erg",
"6erh",
"6zha",
"6zhe",
"7axz",
"7k0y",
"7k1j",
"7k1k",
"7k1n",
"7lsy",
"7lt3",
"7nfc",
"7nfe",
"7sgl",
"7su3",
"7sud",
"7z6o",
"7z87",
"7z88",
"7zt6",
"7zvt",
"7zwa",
"7zyg",
"8ag4",
"8ag5",
"8asc",
"8bh3"... | 50 | [
"PUB00007946",
"PUB00007947",
"PUB00013573",
"PUB00013574",
"PUB00013575",
"PUB00013576",
"PUB00013577",
"PUB00014415",
"PUB00014452"
] | [
"11483577",
"11493912",
"11839498",
"10377944",
"11445083",
"11516951",
"9477961",
"11029034",
"14697755"
] | [
"Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system.",
"Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.",
"DNA double-strand break repair from head ... | [
2001,
2001,
2002,
1999,
2001,
2001,
1998,
2000,
2004
] | 9 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4260
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
3,
23,
2,
1,
1,
2,
6,
1,
1,
6
] | 12 | true | Family | Ku80 | Ku80 | Ku80 | 4 |
IPR024194 | 24,194 | Alginate O-acetyltransferase AlgI/D-alanyl transfer protein DltB | Ac/AlaTfrase_AlgI/DltB | Family | 16,553 | false | false | The biochemically characterised members of this group are enzymes that transfer organic acids, typically fatty acids, onto hydroxyl groups of membrane-embedded targets. They contain a characteristic domain for O-acyl transferases, , in which a conserved histidine has been suggested to be the active site residue [ ]. Th... | [
"GO:0016746"
] | [
"acyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF"
] | [
"PIRSF016636"
] | [
"AlgI_DltB"
] | [
16553
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"6bug",
"6buh",
"6bui",
"8jem",
"8jes",
"8jf2"
] | 6 | [
"PUB00007478",
"PUB00013853",
"PUB00027722",
"PUB00027736",
"PUB00027792"
] | [
"10694878",
"7797557",
"15231808",
"14507360",
"12019221"
] | [
"A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling.",
"Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation.",
"Evidence that the algI/algJ gene cassette, required for O acetylation of Pseudomon... | [
2000,
1995,
2004,
2003,
2002
] | 5 | [
"IPR004299"
] | [
"IPR024024",
"IPR028362"
] | 1 | 2 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
20,
16342,
2,
15,
174
] | 5 | [] | [] | 0 | true | Family | Alginate O-acetyltransferase AlgI/D-alanyl transfer protein DltB | Alginate O-acetyltransferase AlgI/D-alanyl transfer protein DltB | Ac/AlaTfrase_AlgI/DltB | 5 |
IPR024195 | 24,195 | NUDIX hydrolase, YfcD, predicted | NUDIX_hydrolase_YfcD_pred | Family | 3,560 | false | false | This entry represents a family of uncharacterised proteins that contain a NUDIX hydrolase domain ( ). | [
"GO:0016817"
] | [
"hydrolase activity, acting on acid anhydrides"
] | [
"molecular_function"
] | 1 | [
"PIRSF"
] | [
"PIRSF017340"
] | [
"Nudix_hydro"
] | [
3560
] | 1 | [] | [] | [] | 0 | [
"2fkb"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3480,
61,
19
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | NUDIX hydrolase, YfcD, predicted | NUDIX hydrolase, YfcD, predicted | NUDIX_hydrolase_YfcD_pred | 6 |
IPR024196 | 24,196 | [NiFe]-hydrogenase-3-type complex Eha, EhaR | NiFe_hyd_3_EhaR | Family | 67 | false | false | This entry represents proteins that are predicted to be the hydrophilic EhaR subunits of Eha-type energy-converting [NiFe] hydrogenase complexes. [NiFe] hydrogenases function in H2 metabolism in a variety of microorganisms, enabling them to use H2 as a source of reducing equivalent under aerobic and anaerobic condition... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF019370"
] | [
"EhaR"
] | [
67
] | 1 | [] | [] | [] | 0 | [
"1y8a"
] | 1 | [
"PUB00014600",
"PUB00035516",
"PUB00035517",
"PUB00035518",
"PUB00096941"
] | [
"10491142",
"15168611",
"16645307",
"15119826",
"22872868"
] | [
"Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins.",
"Energy-converting [NiFe] hydrogenases from archaea and extremophiles: ancestors of complex I.",
"Energy-converting [NiFe] hydrogenases... | [
1999,
2004,
2005,
2004,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"bioreactor metagenome"
] | [
56,
10,
1
] | 3 | [] | [] | 0 | true | Family | [NiFe]-hydrogenase-3-type complex Eha, EhaR | [NiFe]-hydrogenase-3-type complex Eha, EhaR | NiFe_hyd_3_EhaR | 1 |
IPR024197 | 24,197 | Trehalose phosphatase-like | TPP-like | Family | 2,508 | false | false | This entry represents a family of bacterial proteins that includes Trehalose phosphatase from Pseudomonas aeruginosa (TPP). This enzyme hydrolyses the metabolite trehalose 6-phosphate (T6P), whose accumulation may result in a lethal phenotype. The protein adopts the overall fold of the HAD superfamily ( ) with a Rossma... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF030802"
] | [
"UCP030802"
] | [
2508
] | 1 | [] | [] | [] | 0 | [
"6cj0",
"6d3v",
"6d3w"
] | 3 | [
"PUB00100960"
] | [
"29688811"
] | [
"Trehalose 6-phosphate phosphatases of Pseudomonas aeruginosa."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Acinetobacter phage vB_AbaM_ME3",
"Bacteria",
"ecological metagenomes"
] | [
1,
2504,
3
] | 3 | [] | [] | 0 | true | Family | Trehalose phosphatase-like | Trehalose phosphatase-like | TPP-like | 7 |
IPR024198 | 24,198 | Uncharacterised conserved protein, UCP033642 | UCP033642 | Family | 147 | false | false | There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF033642"
] | [
"UCP033642"
] | [
147
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160784"
] | [
"38748582"
] | [
"YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of <i>Escherichia coli</i>."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
147
] | 1 | [] | [] | 0 | true | Family | Uncharacterised conserved protein, UCP033642 | Uncharacterised conserved protein, UCP033642 | UCP033642 | 6 |
IPR024199 | 24,199 | Uncharacterised conserved protein, DsbB-like | Uncharacterised_DsbB | Family | 2,692 | false | false | This entry represents a family of conserved hypothetical proteins with DsbB domain. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF033913"
] | [
"S-S_format_DsbB"
] | [
2692
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Hyalomma marginatum",
"Pseudomonadati",
"metagenomes"
] | [
1,
2664,
27
] | 3 | [] | [] | 0 | true | Family | Uncharacterised conserved protein, DsbB-like | Uncharacterised conserved protein, DsbB-like | Uncharacterised_DsbB | 7 |
IPR024200 | 24,200 | Chondroitin sulfate ABC endolyase | Chondroitinase_ABC_I | Family | 671 | false | false | Chondroitin sulfate ABC endolyase is a broad-specificity glycosaminoglycan lyase, which degrades the polysaccharides chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate and to a lesser extent hyaluronan [ , ]. It is able to promote functional recovery in the injured central nervous system (CNS),... | [
"GO:0034000",
"GO:0005975"
] | [
"chondroitin-sulfate-ABC endolyase activity",
"carbohydrate metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF034515"
] | [
"Chondroitinase"
] | [
671
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"4.2.2.21",
"PWY-6572",
"PWY-7646"
] | [
"EC:4.2.2.21",
"METACYC:PWY-6572",
"METACYC:PWY-7646"
] | 3 | [
"1hn0",
"2q1f",
"7eip",
"7eiq",
"7eir",
"7eis",
"7yke"
] | 7 | [
"PUB00062134",
"PUB00062135",
"PUB00062136"
] | [
"9083041",
"15691229",
"17572406"
] | [
"Two distinct chondroitin sulfate ABC lyases. An endoeliminase yielding tetrasaccharides and an exoeliminase preferentially acting on oligosaccharides.",
"Chondroitinase ABC I from Proteus vulgaris: cloning, recombinant expression and active site identification.",
"How does chondroitinase promote functional rec... | [
1997,
2005,
2007
] | 3 | [
"IPR039174"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"metagenomes"
] | [
668,
3
] | 2 | [] | [] | 0 | true | Family | Chondroitin sulfate ABC endolyase | Chondroitin sulfate ABC endolyase | Chondroitinase_ABC_I | 6 |
IPR024201 | 24,201 | Calcineurin-like phosphoesterase | Calcineurin-like_Pesterase | Family | 1,807 | false | false | These conserved animal proteins contain one copy of the calcineurin-like phosphoesterase domain ( ) and possess motifs characteristic of a variety of enzymatically active phosphoesterases [ ], including acid and alkaline phosphatases, phosphoprotein phosphatases, 5'-nucleotidase, bis(5'-nucleosyl)-tetraphosphatase (sym... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF035808"
] | [
"Pdiesterase_Brain_239"
] | [
1807
] | 1 | [] | [] | [] | 0 | [
"3rl3",
"3rl4",
"3rl5"
] | 3 | [
"PUB00014394",
"PUB00027986"
] | [
"8683579",
"9266672"
] | [
"Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures.",
"The 239AB gene on chromosome 22: a novel member of an ancient gene family."
] | [
1996,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1807
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
6,
2,
5,
4,
2
] | 6 | true | Family | Calcineurin-like phosphoesterase | Calcineurin-like phosphoesterase | Calcineurin-like_Pesterase | 2 |
IPR024203 | 24,203 | 5-deoxy-glucuronate isomerase, IolB | Deoxy-glucuronate_isom_IolB | Family | 7,565 | false | false | Members of this family include several bacterial myo-inositol catabolism (IolB) proteins. The Bacillus subtilis inositol operon (iolABCDEFGHIJ) is involved in myo-inositol catabolism. Glucose repression of the iol operon induced by inositol is exerted through catabolite repression mediated by CcpA and the iol induction... | [
"GO:0008880",
"GO:0019310"
] | [
"glucuronate isomerase activity",
"inositol catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF036628",
"PTHR39193",
"TIGR04378"
] | [
"IolB",
"",
"myo_inos_iolB"
] | [
7079,
7565,
6535
] | 3 | [
"EC",
"GP",
"GP"
] | [
"5.3.1.30",
"GenProp1071",
"GenProp1286"
] | [
"EC:5.3.1.30",
"GP:GenProp1071",
"GP:GenProp1286"
] | 3 | [
"2qjv"
] | 1 | [
"PUB00012857",
"PUB00053908"
] | [
"11566986",
"18310071"
] | [
"Involvement of two distinct catabolite-responsive elements in catabolite repression of the Bacillus subtilis myo-inositol (iol) operon.",
"myo-Inositol catabolism in Bacillus subtilis."
] | [
2001,
2008
] | 2 | [
"IPR021120"
] | [
"IPR023770"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
9,
7463,
3,
90
] | 4 | [] | [] | 0 | true | Family | 5-deoxy-glucuronate isomerase, IolB | 5-deoxy-glucuronate isomerase, IolB | Deoxy-glucuronate_isom_IolB | 3 |
IPR024204 | 24,204 | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type | Cyt_P450_CYP7A1-type | Family | 4,184 | false | false | This group represents cytochrome P450, CYP7A1 type. Gene cyp7a1 codes for the enzyme cholesterol 7-alpha-monooxygenase, which catalyses a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. This enzyme is important for cholesterol hom... | [
"GO:0004497",
"GO:0005506",
"GO:0016705",
"GO:0020037"
] | [
"monooxygenase activity",
"iron ion binding",
"oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",
"heme binding"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function"
] | 4 | [
"PIRSF"
] | [
"PIRSF000047"
] | [
"Cytochrome_CYPVIIA1"
] | [
4184
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"1.14.14",
"R-BTA-211979",
"R-BTA-2162123",
"R-DRE-211979",
"R-DRE-2162123",
"R-HSA-192105",
"R-HSA-193368",
"R-HSA-193775",
"R-HSA-193807",
"R-HSA-1989781",
"R-HSA-211976",
"R-HSA-211979",
"R-HSA-211994",
"R-HSA-2162123",
"R-HSA-5579013",
"R-MMU-192105",
"R-MMU-193368",
"R-MMU-193... | [
"EC:1.14.14",
"REACTOME:R-BTA-211979",
"REACTOME:R-BTA-2162123",
"REACTOME:R-DRE-211979",
"REACTOME:R-DRE-2162123",
"REACTOME:R-HSA-192105",
"REACTOME:R-HSA-193368",
"REACTOME:R-HSA-193775",
"REACTOME:R-HSA-193807",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-211976",
"REACTOME:R-HSA-211979",
... | 33 | [
"2iag",
"3b6h",
"3b98",
"3b99",
"3dax",
"3sn5",
"3v8d",
"7lyx",
"8eoh"
] | 9 | [
"PUB00055610"
] | [
"8088795"
] | [
"Structure of the mouse cholesterol 7 alpha-hydroxylase gene."
] | [
1994
] | 1 | [
"IPR002403"
] | [
"IPR027286",
"IPR030681",
"IPR030686"
] | 1 | 3 | 0 | [
"Eukaryota",
"Nannocystaceae"
] | [
4176,
8
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
10,
11,
17
] | 4 | true | Family | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type | Cyt_P450_CYP7A1-type | 3 |
IPR024205 | 24,205 | Mst1/2 SARAH domain | Mst1_2_SARAH_domain | Domain | 3,035 | false | false | This entry represents the C-terminal SARAH domain of Serine/threonine-protein kinase 4 (STK4) (also known as Mst1) and STK4 (also known as Mst2). The Mst1 SARAH domain interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process [ ]. The SARAH (Sav/Rassf/Hpo) domain is found at the C t... | [
"GO:0004674"
] | [
"protein serine/threonine kinase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF11629"
] | [
"Mst1_SARAH"
] | [
3035
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"R-BTA-2028269",
"R-CEL-2028269",
"R-DME-2028269",
"R-DME-390089",
"R-DME-390098",
"R-DME-390150",
"R-DME-451806",
"R-DRE-2028269",
"R-HSA-2028269",
"R-MMU-2028269",
"R-RNO-2028269",
"R-XTR-2028269"
] | [
"EC:2.7.11.1",
"REACTOME:R-BTA-2028269",
"REACTOME:R-CEL-2028269",
"REACTOME:R-DME-2028269",
"REACTOME:R-DME-390089",
"REACTOME:R-DME-390098",
"REACTOME:R-DME-390150",
"REACTOME:R-DME-451806",
"REACTOME:R-DRE-2028269",
"REACTOME:R-HSA-2028269",
"REACTOME:R-MMU-2028269",
"REACTOME:R-RNO-2028269... | 13 | [
"2jo8",
"3wws",
"4hkd",
"4l0n",
"4lgd",
"4nr2",
"4oh8",
"4oh9",
"5xcq",
"5xcr",
"5xcs",
"5xct",
"5xcu",
"5xcv",
"5xcx",
"6ao5",
"6bn1",
"6lcs",
"6lz4",
"7cea",
"7ceb",
"7cec",
"7dkj",
"7km6",
"7nwl",
"7x91",
"8hyl",
"8iqp",
"8iqq",
"8iqr",
"8iqs",
"8jg5"... | 36 | [
"PUB00014752",
"PUB00041953",
"PUB00097384"
] | [
"14654011",
"17517604",
"29519817"
] | [
"A novel interaction motif, SARAH, connects three classes of tumor suppressor.",
"Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway.",
"Salvador has an extended SARAH domain that mediates binding to Hippo kinase."
] | [
2003,
2007,
2018
] | 3 | [
"IPR011524"
] | [
"IPR049568"
] | 1 | 1 | 0 | [
"Eukaryota"
] | [
3035
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
8,
5,
12
] | 6 | true | Domain | Mst1/2 SARAH domain | Mst1/2 SARAH domain | Mst1_2_SARAH_domain | 6 |
IPR024206 | 24,206 | Gurmarin/antimicrobial peptide | Gurmarin/antimicrobial_peptd | Family | 254 | false | false | This peptide has six cysteines involved in three disulphide bonds. The presence of a 'disulphide through disulphide knot' structurally defines this protein as a knottin: the peptide contains a global fold which involves a cysteine-knotted three-stranded antiparallel β-sheet along with a flexible loop and four beta-reve... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11410"
] | [
"Antifungal_pept"
] | [
254
] | 1 | [] | [] | [] | 0 | [
"1dkc",
"1q3j"
] | 2 | [
"PUB00013263"
] | [
"11551192"
] | [
"Solution structure of PAFP-S: a new knottin-type antifungal peptide from the seeds of Phytolacca americana."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
254
] | 1 | [] | [] | 0 | true | Family | Gurmarin/antimicrobial peptide | Gurmarin/antimicrobial peptide | Gurmarin/antimicrobial_peptd | 3 |
IPR024207 | 24,207 | Protein CotJB, domain | CotJB_dom | Domain | 2,334 | false | false | The cotJ operon proteins affect spore coat composition, and is controlled by sigma E. The genes, which include CotJB, are either required for the normal formation of the inner layers of the coat or are themselves structural components of the coat [ ]. CotJB has been identified as a spore coat protein [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12652"
] | [
"CotJB"
] | [
2334
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00034417",
"PUB00045969"
] | [
"12480901",
"7768848"
] | [
"Proteomics characterization of novel spore proteins of Bacillus subtilis.",
"Characterization of cotJ, a sigma E-controlled operon affecting the polypeptide composition of the coat of Bacillus subtilis spores."
] | [
2002,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Phytophthora kernoviae 00238/432",
"metagenomes"
] | [
2316,
1,
17
] | 3 | [] | [] | 0 | true | Domain | Protein CotJB, domain | Protein CotJB, domain | CotJB_dom | 4 |
IPR024208 | 24,208 | Protein of unknown function DUF3842 | DUF3842 | Family | 823 | false | false | This family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12953"
] | [
"DUF3842"
] | [
823
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
794,
29
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3842 | Protein of unknown function DUF3842 | DUF3842 | 7 |
IPR024209 | 24,209 | Spore surface protein CDIF630_02480 | CDIF630_02480-like | Family | 346 | false | false | This family of proteins, previously known as DUF3787, represents the spore surface protein CDIF630_02480 from Clostridioides difficile and related proteins found in Clostridia. CDIF630_02480 contribute to maintain proper thickness of the spore coat and exosporium layers [ ]. Members of this family contain a conserved T... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12655"
] | [
"CDIF630_02480-like"
] | [
346
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00152825"
] | [
"36296193"
] | [
"Role of the Spore Coat Proteins <i>CotA</i> and <i>CotB</i>, and the Spore Surface Protein CDIF630_02480, on the Surface Distribution of Exosporium Proteins in <i>Clostridioides difficile</i> 630 Spores."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota",
"bioreactor metagenome"
] | [
336,
10
] | 2 | [] | [] | 0 | true | Family | Spore surface protein CDIF630_02480 | Spore surface protein CDIF630_02480 | CDIF630_02480-like | 7 |
IPR024212 | 24,212 | Domain of unknown function DUF3837 | DUF3837 | Domain | 115 | false | false | This entry represents a small, compact all-α helical domain of unknown function. This domain is currently only found in Clostridiales species. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12939"
] | [
"DUF3837"
] | [
115
] | 1 | [] | [] | [] | 0 | [
"3e0z"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Clostridia"
] | [
115
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3837 | Domain of unknown function DUF3837 | DUF3837 | 5 |
IPR024213 | 24,213 | Protein of unknown function DUF3822 | DUF3822 | Family | 2,506 | false | false | This is a family of uncharacterised bacterial proteins. However, structural-similarity searches indicate the family takes on an actin-like ATPase fold. | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF12864",
"cd24013"
] | [
"DUF3822",
"ASKHA_ATPase_BT3980-like"
] | [
2504,
2432
] | 2 | [] | [] | [] | 0 | [
"3hrg"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halteria grandinella",
"metagenomes"
] | [
2462,
1,
43
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3822 | Protein of unknown function DUF3822 | DUF3822 | 3 |
IPR024214 | 24,214 | Protein of unknown function DUF3843 | DUF3843 | Family | 460 | false | false | A family of uncharacterised proteins found by clustering human gut metagenomic sequences [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12954"
] | [
"DUF3843"
] | [
460
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055601"
] | [
"20532204"
] | [
"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"unclassified sequences"
] | [
449,
11
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3843 | Protein of unknown function DUF3843 | DUF3843 | 3 |
IPR024215 | 24,215 | Protein of unknown function DUF3847 | DUF3847 | Family | 1,492 | false | false | This entry represents a family of uncharacterised proteins that were found by clustering human gut metagenomic sequences [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12958"
] | [
"DUF3847"
] | [
1492
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055601"
] | [
"20532204"
] | [
"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"organismal metagenomes"
] | [
1479,
13
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3847 | Protein of unknown function DUF3847 | DUF3847 | 5 |
IPR024216 | 24,216 | Protein of unknown function DUF3851 | DUF3851 | Family | 170 | false | false | This entry represents a family of uncharacterised proteins that were found by clustering human gut metagenomic sequences [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12962"
] | [
"DUF3851"
] | [
170
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055601"
] | [
"20532204"
] | [
"Expansion of the protein repertoire in newly explored environments: human gut microbiome specific protein families."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eutreptiella gymnastica",
"human gut metagenome"
] | [
166,
1,
3
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3851 | Protein of unknown function DUF3851 | DUF3851 | 6 |
IPR024217 | 24,217 | Protein of unknown function DUF3813 | DUF3813 | Family | 654 | false | false | This entry represents a family of proteins mainly found in Bacillus, including Uncharacterized protein YizC from Bacillus subtilis (strain 168). YizC might be involved in sporulation [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12758"
] | [
"DUF3813"
] | [
654
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100131"
] | [
"32061128"
] | [
"Evolutionary Analysis of the Bacillus subtilis Genome Reveals New Genes Involved in Sporulation."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
654
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3813 | Protein of unknown function DUF3813 | DUF3813 | 7 |
IPR024218 | 24,218 | Protein of unknown function DUF3867 | DUF3867 | Family | 202 | false | false | This entry represents a family of functionally uncharacterised proteins that are found in bacteria. Proteins in this family are approximately 190 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12983"
] | [
"DUF3867"
] | [
202
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Clostridia",
"bioreactor metagenome"
] | [
198,
4
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3867 | Protein of unknown function DUF3867 | DUF3867 | 7 |
IPR024219 | 24,219 | Protein of unknown function DUF3809 | DUF3809 | Family | 124 | false | false | This group of proteins is found in the Deinococci bacteria. It is functionally uncharacterised. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12723"
] | [
"DUF3809"
] | [
124
] | 1 | [] | [] | [] | 0 | [
"3nqn",
"5im6"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Deinococci"
] | [
124
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3809 | Protein of unknown function DUF3809 | DUF3809 | 3 |
IPR024220 | 24,220 | Protein of unknown function DUF3780 | DUF3780 | Family | 241 | false | false | This family of proteins have no known function. There are two conserved sequence motifs: PEERWWL and GWR. This family is found in a very sporadic set of bacterial species, suggesting that it may have been horizontally transferred. One protein ( ) is annotated as occurring on a plasmid. | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF042961",
"PF12635"
] | [
"DUF3780_antiphage",
"DUF3780"
] | [
120,
241
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00152882"
] | [
"32855333"
] | [
"Diverse enzymatic activities mediate antiviral immunity in prokaryotes."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"metagenomes"
] | [
235,
3,
3
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3780 | Protein of unknown function DUF3780 | DUF3780 | 1 |
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