interpro_id
string
interpro_numeric_id
int64
name
string
short_name
string
entry_type
string
protein_count
int64
is_llm
bool
is_llm_reviewed
bool
abstract
string
go_ids
list
go_terms
list
go_categories
list
go_count
int64
member_databases
list
member_accessions
list
member_names
list
member_protein_counts
list
member_count
int64
external_databases
list
external_accessions
list
external_xrefs
list
external_xref_count
int64
pdb_ids
list
structure_count
int64
publication_ids
list
pubmed_ids
list
publication_titles
list
publication_years
list
publication_count
int64
parent_ids
list
child_ids
list
parent_count
int64
child_count
int64
tree_depth
float64
taxonomy_names
list
taxonomy_protein_counts
list
taxonomy_count
int64
key_species_names
list
key_species_protein_counts
list
key_species_count
int64
in_entry_list
bool
entry_list_type
string
entry_list_name
string
names_dat_name
string
short_names_dat_name
string
split_bucket
int64
IPR054142
54,142
AppA, SCHIC domain
AppA_SCHIC
Domain
15
false
false
This domain is found at the C-terminal end of AppA protein from Rhodobacter sphaeroides and similar sequences from alphaproteobacteria. AppA is a light-sensing antirepressor involved in oxygen and light control of photosynthesis-gene expression. This protein senses blue-light via its N-terminal blue-light using FAD (BL...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21966" ]
[ "AppA_SCHIC" ]
[ 15 ]
1
[]
[]
[]
0
[ "4heh", "4hh0", "4hh1", "4hh3" ]
4
[ "PUB00153821", "PUB00153822" ]
[ "23982072", "23728293" ]
[ "Redox and light control the heme-sensing activity of AppA.", "A ternary AppA-PpsR-DNA complex mediates light regulation of photosynthesis-related gene expression." ]
[ 2013, 2013 ]
2
[]
[]
0
0
null
[ "Alphaproteobacteria" ]
[ 15 ]
1
[]
[]
0
true
Domain
AppA, SCHIC domain
AppA, SCHIC domain
AppA_SCHIC
2
IPR054143
54,143
Mannosylglycerate synthase, C-terminal domain
MGS_C
Domain
33
false
false
Mannosylglycerate synthase catalyses the formation of the stress protectant 2-O-alpha-D-mannosyl glycerate [ ]. It consists of an N-terminal GT-like domain and a C-terminal helical domain, which is represented in this entry, that is apparently involved in protein oligomerization [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF21967" ]
[ "MGS_C" ]
[ 33 ]
1
[]
[]
[]
0
[ "2bo4", "2bo6", "2bo7", "2bo8", "2y4j", "2y4k", "2y4l", "2y4m" ]
8
[ "PUB00039698" ]
[ "15951819" ]
[ "Structural dissection and high-throughput screening of mannosylglycerate synthase." ]
[ 2005 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota" ]
[ 4, 29 ]
2
[]
[]
0
true
Domain
Mannosylglycerate synthase, C-terminal domain
Mannosylglycerate synthase, C-terminal domain
MGS_C
9
IPR054144
54,144
TcdA1, receptor binding domain 1
TcdA1_RBD_1
Domain
22
false
false
This domain is found in TcdA1 from Photorhabdus luminescens and similar sequences from proteobacteria. TcdA1 is one of the three subunits of the Tc toxins. TcdA1 acts as an injecting device responsible for translocating the actual toxic component into host cells. TcA has four receptor-binding domains. This domain is on...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21968" ]
[ "TcdA1_RBD_3" ]
[ 22 ]
1
[]
[]
[]
0
[ "4o9y", "5lkh", "5lki", "6h6e", "6h6f", "6l7e", "6rw6", "6sue", "6suf", "8cpz", "8cq0", "8cq2" ]
12
[ "PUB00091290", "PUB00154263" ]
[ "24572368", "31663026" ]
[ "Mechanism of Tc toxin action revealed in molecular detail.", "Common architecture of Tc toxins from human and insect pathogenic bacteria." ]
[ 2014, 2019 ]
2
[]
[]
0
0
null
[ "Enterobacterales" ]
[ 22 ]
1
[]
[]
0
true
Domain
TcdA1, receptor binding domain 1
TcdA1, receptor binding domain 1
TcdA1_RBD_1
5
IPR054145
54,145
Mannosylglycerate synthase, GT domain
MGS_GT
Domain
82
false
false
Mannosylglycerate synthase catalyses the formation of the stress protectant 2-O-alpha-D-mannosyl glycerate [ ]. It consists of a N-terminal GT-like domain and a C-terminal helical domain [ ]. This entry represents the N-terminal glycosyltransferase domain (GT) which, at the sequence level, is most similar to family-GT2...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21969" ]
[ "MGS_GT" ]
[ 82 ]
1
[]
[]
[]
0
[ "2bo4", "2bo6", "2bo7", "2bo8", "2y4j", "2y4k", "2y4l", "2y4m" ]
8
[ "PUB00039698", "PUB00061138" ]
[ "15951819", "21288903" ]
[ "Structural dissection and high-throughput screening of mannosylglycerate synthase.", "Substrate and metal ion promiscuity in mannosylglycerate synthase." ]
[ 2005, 2011 ]
2
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "anaerobic digester metagenome" ]
[ 22, 19, 40, 1 ]
4
[]
[]
0
true
Domain
Mannosylglycerate synthase, GT domain
Mannosylglycerate synthase, GT domain
MGS_GT
1
IPR054146
54,146
HOXB-AS3 peptide
HOXB-AS3
Family
3
false
false
This family represents human HOXB-AS3 peptide, a 53-residues peptide that suppresses colon cancer (CRC) growth but is associated with a poor prognosis in oral squamous cell carcinoma (OSCC) [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF21970" ]
[ "HOXB-AS3" ]
[ 3 ]
1
[]
[]
[]
0
[]
0
[ "PUB00154011", "PUB00154012" ]
[ "34457052", "28985503" ]
[ "A micro-peptide encoded by HOXB-AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c-Myc.", "A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth." ]
[ 2021, 2017 ]
2
[]
[]
0
0
null
[ "Catarrhini" ]
[ 3 ]
1
[ "Homo sapiens" ]
[ 1 ]
1
true
Family
HOXB-AS3 peptide
HOXB-AS3 peptide
HOXB-AS3
3
IPR054147
54,147
Transcriptional regulator PINT87aa
LINC-PINT
Family
3
false
false
This protein family represents human Transcriptional regulator PINT87aa (LINC-PINT), an 87-residues peptide encoded by a circular RNA (circRNA) that suppresses glioblastoma cell proliferation in vitro and in vivo. It has been established as a biomarker and a key regulator of cellular senescence in hepatocellular carcin...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21971" ]
[ "LINC-PINT" ]
[ 3 ]
1
[]
[]
[]
0
[]
0
[ "PUB00103428", "PUB00154039" ]
[ "33754036", "30367041" ]
[ "Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated <i>PHB2</i>.", "A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma." ]
[ 2021, 2018 ]
2
[]
[]
0
0
null
[ "Boreoeutheria" ]
[ 3 ]
1
[ "Homo sapiens", "Rattus norvegicus" ]
[ 1, 1 ]
2
true
Family
Transcriptional regulator PINT87aa
Transcriptional regulator PINT87aa
LINC-PINT
4
IPR054148
54,148
ASNSD1 upstream open reading frame protein
ASNSD1-SEP
Family
466
false
false
This family includes human ASNSD1 upstream open reading frame protein (ASNSD1-SEP, for small/short open reading frame -encoded polypeptide) and similar sequences predominantly found in vertebrates. ASNSD1-SEP is a subunit of the prefoldin-like (PFDL) module of the PAQosome, an 11-subunit chaperone involved in the bioge...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21975" ]
[ "ASNSD1-SEP" ]
[ 466 ]
1
[]
[]
[]
0
[]
0
[ "PUB00153829" ]
[ "31738558" ]
[ "Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome." ]
[ 2020 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 466 ]
1
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 5, 1, 1 ]
4
true
Family
ASNSD1 upstream open reading frame protein
ASNSD1 upstream open reading frame protein
ASNSD1-SEP
4
IPR054149
54,149
Small integral membrane protein 43
SMIM43
Family
110
false
false
This protein family includes human Small integral membrane protein 43 (SMIM43, also known as NEMEP) and similar sequences from vertebrates. This protein has been associated with HIV and hepatitis C infection as well as with brain tumours and probably with essential tremor, cerebellar atrophy and other disorders [ ]. It...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21976" ]
[ "SMIM43" ]
[ 110 ]
1
[]
[]
[]
0
[]
0
[ "PUB00154238", "PUB00154433" ]
[ "37077524", "35810171" ]
[ "Gene dysregulation in acute HIV-1 infection - early transcriptomic analysis reveals the crucial biological functions affected.", "A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells." ]
[ 2023, 2022 ]
2
[]
[]
0
0
null
[ "Euteleostomi" ]
[ 110 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 1, 1 ]
3
true
Family
Small integral membrane protein 43
Small integral membrane protein 43
SMIM43
4
IPR054150
54,150
Transcriptional regulator SEHBP
SEHBP
Family
4
false
false
This protein family represents human Transcriptional regulator SEHBP (short ORF-encoded histone binding protein), a conserved microprotein that interacts with chromatin-associated proteins and acts as a transcription factor [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF21978" ]
[ "SEHBP" ]
[ 4 ]
1
[]
[]
[]
0
[]
0
[ "PUB00154227" ]
[ "33468658" ]
[ "A short ORF-encoded transcriptional regulator." ]
[ 2021 ]
1
[]
[]
0
0
null
[ "Boreoeutheria" ]
[ 4 ]
1
[ "Homo sapiens", "Mus musculus" ]
[ 1, 1 ]
2
true
Family
Transcriptional regulator SEHBP
Transcriptional regulator SEHBP
SEHBP
2
IPR054151
54,151
TR61B, FKBP-like domain
TR61B_FKBP-like
Domain
863
false
false
This is the FKBP-like domain found towards the N-terminal of TR61B (tRNA (adenine(58)-N(1))-methyltransferase) from human and similar proteins. This mitochondrion-specific protein catalyses the formation of N1-methyladenine at position 58 (m1A58) in various tRNAs [ ] and the formation of 1-methyladenosine at position 9...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21985" ]
[ "TR61B_FKBP-like" ]
[ 863 ]
1
[ "REACTOME", "REACTOME" ]
[ "R-HSA-6787450", "R-HSA-9937008" ]
[ "REACTOME:R-HSA-6787450", "REACTOME:R-HSA-9937008" ]
2
[ "2b25" ]
1
[ "PUB00154295", "PUB00154296" ]
[ "23097428", "27631568" ]
[ "Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs.", "Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates." ]
[ 2012, 2016 ]
2
[]
[]
0
0
null
[ "Bacteria", "Caldiarchaeum subterraneum", "Opisthokonta" ]
[ 4, 1, 858 ]
3
[ "Danio rerio", "Homo sapiens", "Rattus norvegicus" ]
[ 1, 2, 1 ]
3
true
Domain
TR61B, FKBP-like domain
TR61B, FKBP-like domain
TR61B_FKBP-like
1
IPR054152
54,152
YajR, YAM domain
YajR_YAM
Domain
2,728
false
false
This entry represents the C-terminal YAM domain of YajR, an Escherichia coli transporter that belongs to the major facilitator superfamily and similar bacterial proteins. The YAM domain precise regulatory role is not yet known, it may sense environmental changes, such as pH and halogen ion variation [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF21987" ]
[ "YajR_YAM" ]
[ 2728 ]
1
[]
[]
[]
0
[ "2ru9", "3wdo", "4q2l", "4q2m" ]
4
[ "PUB00143352", "PUB00143353" ]
[ "23950222", "24952155" ]
[ "Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A.", "Atomic resolution structure of the E. coli YajR transporter YAM domain." ]
[ 2013, 2014 ]
2
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 2714, 4, 10 ]
3
[ "Escherichia coli (strain K12)", "Homo sapiens" ]
[ 1, 1 ]
2
true
Domain
YajR, YAM domain
YajR, YAM domain
YajR_YAM
2
IPR054153
54,153
Tailspike protein, galactose-binding domain-like
G7C_GBD
Domain
8
false
false
This entry represents the Tailspike galactose-binding domain-like domain, also known as domain 5 (d5) of the tailspike receptor-binding protein (RBP) gp63.1 of bacteriophage G7C. This domain is structurally similar to carbohydrate-binding modules (CBMs) and is involved in substrate binding. Specifically, gp63.1 deacety...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21988" ]
[ "G7C_GBD" ]
[ 8 ]
1
[]
[]
[]
0
[ "4qnl" ]
1
[ "PUB00091258" ]
[ "28513100" ]
[ "Function of bacteriophage G7C esterase tailspike in host cell adsorption." ]
[ 2017 ]
1
[]
[]
0
0
null
[ "Caudoviricetes", "Enterobacterales" ]
[ 3, 5 ]
2
[]
[]
0
true
Domain
Tailspike protein, galactose-binding domain-like
Tailspike protein, galactose-binding domain-like
G7C_GBD
4
IPR054154
54,154
Peroxisomal membrane protein PEX14, central, plants
PEX14-like_M_plants
Domain
1,182
false
false
This domain is centrally located in Peroxisomal membrane protein PEX14 from Arabidopsis thaliana and similar plant sequences. PEX14 is a component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. It is often found C-term...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23020" ]
[ "PEX14-like_2nd" ]
[ 1182 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1182 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 3, 6, 48 ]
3
true
Domain
Peroxisomal membrane protein PEX14, central, plants
Peroxisomal membrane protein PEX14, central, plants
PEX14-like_M_plants
6
IPR054156
54,156
Transcriptional regulator LmrA/YxaF-like, C-terminal domain
YxaF_TetR_C
Domain
9,032
false
false
This entry represents the C-terminal domain found in a group of TetR transcription regulators, including YxaF (also known as T1414) [ ] and LmrA from Bacillus subtilis, which are paralogous to each other [ ]. LmrA and YxaF are repressors that bind specifically to almost the same cis sequences, LmrA/YxaF boxes, located ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21993" ]
[ "TetR_C_13_2" ]
[ 9032 ]
1
[]
[]
[]
0
[ "1sgm", "3dpj", "3on4" ]
3
[ "PUB00037610", "PUB00154270" ]
[ "16475182", "17483215" ]
[ "Crystal structure of a putative HTH-type transcriptional regulator yxaF from Bacillus subtilis.", "Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in response to flavonoids." ]
[ 2006, 2007 ]
2
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriota", "ecological metagenomes" ]
[ 8984, 5, 12, 31 ]
4
[]
[]
0
true
Domain
Transcriptional regulator LmrA/YxaF-like, C-terminal domain
Transcriptional regulator LmrA/YxaF-like, C-terminal domain
YxaF_TetR_C
9
IPR054158
54,158
B12-dependent ribonucleotide reductase, insertion domain
RNR-II_ins_dom
Domain
1,607
false
false
This entry represents the insertion domain of adenosylcobalamin-dependent ribonucleoside-triphosphate reductases (class II RNRs) from Lactococcus leichmannii and related sequences. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA, a rate-limiting step of DNA biosynth...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21995" ]
[ "RNR-II_ins_dom" ]
[ 1607 ]
1
[ "EC" ]
[ "1.17.4.2" ]
[ "EC:1.17.4.2" ]
1
[ "1l1l" ]
1
[ "PUB00007088" ]
[ "11875520" ]
[ "The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer." ]
[ 2002 ]
1
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]
[ 4, 882, 182, 480, 59 ]
5
[]
[]
0
true
Domain
B12-dependent ribonucleotide reductase, insertion domain
B12-dependent ribonucleotide reductase, insertion domain
RNR-II_ins_dom
9
IPR054160
54,160
MrkD-like, receptor binding domain
MrkD_recept-bd
Domain
1,443
false
false
This entry represents the receptor binding domain of MrkD from Klebsiella pneumoniae and similar sequences [ ]. MkrD is an adhesin protein that specifically interacts with type IV and/or V collagen [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF22003" ]
[ "MrkDrd" ]
[ 1443 ]
1
[ "REACTOME" ]
[ "R-HSA-9638630" ]
[ "REACTOME:R-HSA-9638630" ]
1
[ "3u4k", "8dez", "8df0", "8dka", "9q1h" ]
5
[ "PUB00154079" ]
[ "22988966" ]
[ "Crystal structure of the MrkD1P receptor binding domain of Klebsiella pneumoniae and identification of the human collagen V binding interface." ]
[ 2012 ]
1
[]
[]
0
0
null
[ "Opisthokonta", "Pseudomonadati" ]
[ 5, 1438 ]
2
[]
[]
0
true
Domain
MrkD-like, receptor binding domain
MrkD-like, receptor binding domain
MrkD_recept-bd
3
IPR054161
54,161
Small regulatory polypeptide of amino acid response
SPAR
Family
97
false
false
This family represents human small regulatory polypeptide of amino acid response (SPAR) and similar sequences from vertebrates. SPAR interacts with the lysosomal v-ATPase to negatively regulate the activation of the signalling complex mTORC1 upon stimulation with amino acids. It also acts as a regulator of muscle regen...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22004" ]
[ "SPAR" ]
[ 97 ]
1
[]
[]
[]
0
[]
0
[ "PUB00154239" ]
[ "28024296" ]
[ "mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide." ]
[ 2017 ]
1
[]
[]
0
0
null
[ "Eutheria" ]
[ 97 ]
1
[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 1, 1, 2 ]
3
true
Family
Small regulatory polypeptide of amino acid response
Small regulatory polypeptide of amino acid response
SPAR
2
IPR054162
54,162
DUF6293, C-terminal winged helix domain
DUF6293_C
Domain
430
false
false
This domain is found C-terminal in functionally uncharacterised archaeal proteins. This domain is predicted to adopt a winged helix domain structure. It is usually associated to .
[]
[]
[]
0
[ "PFAM" ]
[ "PF22665" ]
[ "WHD_DUF6293" ]
[ 430 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "ecological metagenomes" ]
[ 403, 16, 11 ]
3
[]
[]
0
true
Domain
DUF6293, C-terminal winged helix domain
DUF6293, C-terminal winged helix domain
DUF6293_C
6
IPR054163
54,163
LPP20 lipofamily protein, C-terminal domain
HP1454-like_C
Domain
109
false
false
This domain is found at the C-terminal end of LPP20 lipofamily protein from Helicobacter pylori (HP1454) and similar sequences predominantly found in epsilonproteobacteria. HP1454 is a secreted protein composed of three distinct domains: the N-terminal ( ), the middle domain ( ) and this domain, which shows a β-sheet f...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22017" ]
[ "HP1454-like_C" ]
[ 109 ]
1
[]
[]
[]
0
[ "4kzs" ]
1
[ "PUB00154013" ]
[ "24854568" ]
[ "Crystal structure of the secreted protein HP1454 from the human pathogen Helicobacter pylori." ]
[ 2014 ]
1
[]
[]
0
0
null
[ "Helicobacter" ]
[ 109 ]
1
[]
[]
0
true
Domain
LPP20 lipofamily protein, C-terminal domain
LPP20 lipofamily protein, C-terminal domain
HP1454-like_C
3
IPR054164
54,164
Restriction endonuclease BpuSI, specificity domain
BpuSI_TRD
Domain
26
false
false
This domain is found at the C-terminal of the restriction endonuclease BpuSI from Bacillus pumilus ( ) and similar bacterial sequences. BpuSI is a Type IIG restriction endonuclease that consists of three functional domains: an N-terminal domain , a N-6 DNA methylase domain and a C-terminal specificity domain (TRD, this...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22008" ]
[ "BpuSI_TRD" ]
[ 26 ]
1
[]
[]
[]
0
[ "3s1s" ]
1
[ "PUB00069815" ]
[ "21724614" ]
[ "Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI." ]
[ 2011 ]
1
[]
[]
0
0
null
[ "Bacteria", "hydrothermal vent metagenome" ]
[ 25, 1 ]
2
[]
[]
0
true
Domain
Restriction endonuclease BpuSI, specificity domain
Restriction endonuclease BpuSI, specificity domain
BpuSI_TRD
8
IPR054165
54,165
LPP20 lipofamily protein, middle domain
HP1454-like_M
Domain
106
false
false
This domain is found in LPP20 lipofamily protein from Helicobacter pylori (HP1454) and similar sequences mainly found in epsilonproteobacteria. HP1454 is a secreted protein composed of three distinct domains: the N-terminal ( ), this domain and the C-terminal ( ). This domain forms an anti-parallel three-helix bundle [...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22018" ]
[ "HP1454-like_middle_dom" ]
[ 106 ]
1
[]
[]
[]
0
[ "4kzs" ]
1
[ "PUB00154013" ]
[ "24854568" ]
[ "Crystal structure of the secreted protein HP1454 from the human pathogen Helicobacter pylori." ]
[ 2014 ]
1
[]
[]
0
0
null
[ "Helicobacter" ]
[ 106 ]
1
[]
[]
0
true
Domain
LPP20 lipofamily protein, middle domain
LPP20 lipofamily protein, middle domain
HP1454-like_M
6
IPR054166
54,166
Tyrosine-protein kinase receptor torso, third FN3 domain
Tor_FN3_3nd
Domain
70
false
false
This domain is found in the Tyrosine-protein kinase receptor torso from Bombyx mori (Tor), which is involved in the initiation of metamorphosis during postembryonic development. This protein is organised into three consecutive fibronectin type III (FN3) domains and a C-terminal Kinase domain. This entry represents the ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23008" ]
[ "FN3_Tor_3rd" ]
[ 70 ]
1
[]
[]
[]
0
[]
0
[ "PUB00151810" ]
[ "26698662" ]
[ "Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso." ]
[ 2015 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 70 ]
1
[]
[]
0
true
Domain
Tyrosine-protein kinase receptor torso, third FN3 domain
Tyrosine-protein kinase receptor torso, third FN3 domain
Tor_FN3_3nd
7
IPR054167
54,167
Tyrosine-protein kinase receptor torso, first FN3 domain
Tor_FN3_1st
Domain
48
false
false
This domain is found in the Tyrosine-protein kinase receptor torso from Bombyx mori (Tor), which is involved in the initiation of metamorphosis during postembryonic development. This protein is organised into three consecutive fibronectin type III (FN3) domains and a C-terminal kinase domain. This entry represents the ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF23006" ]
[ "Tor_FN3_1st" ]
[ 48 ]
1
[]
[]
[]
0
[ "5aoq" ]
1
[ "PUB00151810" ]
[ "26698662" ]
[ "Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso." ]
[ 2015 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 48 ]
1
[]
[]
0
true
Domain
Tyrosine-protein kinase receptor torso, first FN3 domain
Tyrosine-protein kinase receptor torso, first FN3 domain
Tor_FN3_1st
6
IPR054168
54,168
PG_1098 ferredoxin-like domain
PG_1098_Fer
Domain
2,532
false
false
This entry represents a ferredoxin-like domain found in a group of poorly characterised sequences, including the putative methyltransferase PG_1098 from Porphyromonas gingivalis ( , ). Members of this entry contain a THUMP-like domain at the C-terminal ( ), following this domain.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22013" ]
[ "PG_1098_Fer" ]
[ 2532 ]
1
[]
[]
[]
0
[ "3ll7" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Microviridae sp. ctCVC7", "Tanacetum cinerariifolium", "metagenomes" ]
[ 2503, 1, 1, 27 ]
4
[]
[]
0
true
Domain
PG_1098 ferredoxin-like domain
PG_1098 ferredoxin-like domain
PG_1098_Fer
7
IPR054169
54,169
1,4-alpha-glucan branching enzyme GlgB, N-terminal domain
GlgB_N
Domain
12,116
false
false
This is the N-terminal β-sandwich domain of 1,4-alpha-glucan branching enzyme GlgB and related proteins. This domain has a differential preference in substrate recognition and binding during amylase activity, when amylose is used as a substrate [ , , , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF22019" ]
[ "GlgB_N" ]
[ 12116 ]
1
[ "EC", "METACYC", "METACYC", "METACYC" ]
[ "2.4.1.18", "PWY-5067", "PWY-622", "PWY-7900" ]
[ "EC:2.4.1.18", "METACYC:PWY-5067", "METACYC:PWY-622", "METACYC:PWY-7900" ]
4
[ "3k1d", "5gqu", "5gqv", "5gqw", "5gqx", "5gqy", "5gqz", "5gr0", "5gr1", "5gr2", "5gr3", "5gr4", "5gr5", "5gr6", "6klf" ]
15
[ "PUB00153973", "PUB00153974", "PUB00153975", "PUB00153976" ]
[ "20444687", "26280198", "27139627", "28193843" ]
[ "Crystal structure of full-length Mycobacterium tuberculosis H37Rv glycogen branching enzyme: insights of N-terminal beta-sandwich in substrate specificity and enzymatic activity.", "Crystal Structures of Escherichia coli Branching Enzyme in Complex with Linear Oligosaccharides.", "Crystal structures of Escheri...
[ 2010, 2015, 2016, 2017 ]
4
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]
[ 15, 11997, 10, 94 ]
4
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Domain
1,4-alpha-glucan branching enzyme GlgB, N-terminal domain
1,4-alpha-glucan branching enzyme GlgB, N-terminal domain
GlgB_N
8
IPR054170
54,170
RlmL, ferredoxin-like domain
RlmL_1st
Domain
15,779
false
false
This entry represents the ferredoxin-like domain found at the N-terminal of RmlL, referred to as NFLD domain usually fused to the THUMP domain [ ]. Ribosomal RNA large subunit methyltransferase K/L from E.coli (also known as YcbY) specifically methylates the guanine in positions 2445 and 2069 of 23S rRNA before its ass...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22020" ]
[ "RlmL_1st" ]
[ 15779 ]
1
[ "EC", "EC" ]
[ "2.1.1.173", "2.1.1.264" ]
[ "EC:2.1.1.173", "EC:2.1.1.264" ]
2
[ "3k0b", "3ldg", "3ldu", "3v8v", "3v97" ]
5
[ "PUB00100798" ]
[ "22362734" ]
[ "Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA." ]
[ 2012 ]
1
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 48, 15371, 215, 145 ]
4
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Domain
RlmL, ferredoxin-like domain
RlmL, ferredoxin-like domain
RlmL_1st
9
IPR054171
54,171
RbmA-like, FnIII domain
RbmA-like_FnIII
Domain
54
false
false
This entry represents both fibronectin type III (FnIII) domains found in Vibrio cholerae scaffolding protein RbmA ( ), a biofilm matrix protein essential for both maintenance of rugose colony morphology and development of wild-type biofilm architecture [ ]. RbmA contains two FnIII domains connected by a linker segment....
[]
[]
[]
0
[ "PFAM" ]
[ "PF22021" ]
[ "RbmA-like_FnIII" ]
[ 54 ]
1
[]
[]
[]
0
[ "4be5", "4be6", "4bei", "4kkp", "4kkq", "4kkr", "5g50" ]
7
[ "PUB00154194", "PUB00154195" ]
[ "24340031", "23687270" ]
[ "Structural insights into RbmA, a biofilm scaffolding protein of V. cholerae.", "Structural basis for biofilm formation via the Vibrio cholerae matrix protein RbmA." ]
[ 2013, 2013 ]
2
[]
[]
0
0
null
[ "Pseudomonadati" ]
[ 54 ]
1
[]
[]
0
true
Domain
RbmA-like, FnIII domain
RbmA-like, FnIII domain
RbmA-like_FnIII
7
IPR054172
54,172
Major capsid protein VP16-like
VP16-like
Family
28
false
false
This family includes the major capsid protein VP16 from Thermus virus P23-77, which shows two turrets, producing a crenellated appearance [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF22024" ]
[ "VP16-like" ]
[ 28 ]
1
[]
[]
[]
0
[ "3zmo", "3zn4", "3zn5", "3zn6" ]
4
[ "PUB00067131" ]
[ "23623731" ]
[ "Bacteriophage p23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage." ]
[ 2013 ]
1
[]
[]
0
0
null
[ "Deinococci", "Hukuchivirus", "marine sediment metagenome" ]
[ 25, 2, 1 ]
3
[]
[]
0
true
Family
Major capsid protein VP16-like
Major capsid protein VP16-like
VP16-like
8
IPR054174
54,174
Alpha-amylase-like, C-terminal domain
Alpha-amylase-like_C
Domain
1,405
false
false
This is the C-terminal domain of Anoxybacillus alpha-amylase ( ) and related enzymes. This domain follows the catalytic β/α domain. It folds into a β-sandwich with a greek key topology ( ) [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF22026" ]
[ "Alpha-amylase_C_2" ]
[ 1405 ]
1
[]
[]
[]
0
[ "2wc7", "2wcs", "2wkg", "4e2o", "5a2a", "5a2b", "5a2c" ]
7
[ "PUB00059765", "PUB00154425" ]
[ "19768689", "26975884" ]
[ "Structural features of the Nostoc punctiforme debranching enzyme reveal the basis of its mechanism and substrate specificity.", "Crystal structure of Anoxybacillus α-amylase provides insights into maltose binding of a new glycosyl hydrolase subclass." ]
[ 2010, 2016 ]
2
[]
[]
0
0
null
[ "Bacteria", "Opisthokonta", "Thermococcaceae", "bioreactor metagenome" ]
[ 1397, 4, 3, 1 ]
4
[]
[]
0
true
Domain
Alpha-amylase-like, C-terminal domain
Alpha-amylase-like, C-terminal domain
Alpha-amylase-like_C
7
IPR054175
54,175
NS3 RNA helicase, C-terminal helical domain
NS3_helicase_C
Domain
25,179
false
false
This entry represents the C-terminal all-α helical domain (referred to as domain 3) of hepatitis C virus RNA helicase (NS3) [ , , , , ]. NS3 helicase consists of three domains, separated by a series of clefts. Bound ssDNA lies in a channel that separates domain 3 from domains 1 and 2. The 5' end of the oligonucleotide ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22027" ]
[ "NS3_helicase_C" ]
[ 25179 ]
1
[ "EC", "EC", "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME" ]
[ "2.7.7.48", "3.4.21.98", "3.4.22.-", "3.6.1.15", "3.6.4.13", "PWY-6545", "PWY-7184", "PWY-7185", "PWY-7198", "PWY-7210", "R-HSA-5621480", "R-HSA-8854214" ]
[ "EC:2.7.7.48", "EC:3.4.21.98", "EC:3.4.22.-", "EC:3.6.1.15", "EC:3.6.4.13", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7185", "METACYC:PWY-7198", "METACYC:PWY-7210", "REACTOME:R-HSA-5621480", "REACTOME:R-HSA-8854214" ]
12
[ "1a1v", "1cu1", "1hei", "2f55", "2zjo", "3kqh", "3kqk", "3kql", "3kqn", "3kqu", "3o8b", "3o8c", "3o8d", "3o8r", "3rvb", "4a92", "4b6e", "4b6f", "4b71", "4b73", "4b74", "4b75", "4b76", "4ojq", "4ok3", "4ok5", "4ok6", "4oks", "4wxp", "4wxr", "5e4f", "5fps"...
36
[ "PUB00023240", "PUB00025639", "PUB00028307", "PUB00040542", "PUB00058566" ]
[ "9493270", "9187654", "10574797", "16306038", "20080715" ]
[ "Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.", "Structure of the hepatitis C virus RNA helicase domain.", "Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bi...
[ 1998, 1997, 1999, 2006, 2010 ]
5
[]
[]
0
0
null
[ "Riboviria" ]
[ 25179 ]
1
[]
[]
0
true
Domain
NS3 RNA helicase, C-terminal helical domain
NS3 RNA helicase, C-terminal helical domain
NS3_helicase_C
7
IPR054176
54,176
Inner capsid protein lambda-1/VP3
Lamba1_VP3
Domain
275
false
false
The reovirus inner capsid protein lambda-1 displays nucleoside triphosphate phosphohydrolase (NTPase), RNA-5'-triphosphatase (RTPase), and RNA helicase activity and may play a role in the transcription of the virus genome, the unwinding or reannealing of double-stranded RNA during RNA synthesis. Lambda1 is an Orthoreov...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22033" ]
[ "Lamba1_VP3" ]
[ 275 ]
1
[]
[]
[]
0
[ "1ej6", "2cse", "3iyl", "3k1q", "5zvs", "5zvt", "6m99", "6xf7", "6xf8", "6zts", "6ztz", "7elh", "7yed", "7yev", "7yez", "7yf0", "7yfe", "8fjk", "8fjl", "9cyx", "9cyy" ]
21
[ "PUB00028441", "PUB00040091", "PUB00097604", "PUB00129160", "PUB00154032" ]
[ "10801118", "16216585", "20036256", "20398923", "32895380" ]
[ "Structure of the reovirus core at 3.6 A resolution.", "Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution.", "Backbone model of an aquareovirus virion by cryo-electron microscopy and bioinformatics.", "3.3 A cryo...
[ 2000, 2005, 2010, 2010, 2020 ]
5
[]
[]
0
0
null
[ "Reovirales" ]
[ 275 ]
1
[]
[]
0
true
Domain
Inner capsid protein lambda-1/VP3
Inner capsid protein lambda-1/VP3
Lamba1_VP3
7
IPR054177
54,177
Uncharacterized protein B-129, C2H2 zinc finger
B129_C2H2-Znf
Domain
39
false
false
This entry represents a C2H2 zinc finger found at the C-terminal of a group of poorly characterised viral and archaeal proteins, including the uncharacterised protein B-129 from Sulfolobus spindle-shape virus 1 (SSV1).
[]
[]
[]
0
[ "PFAM" ]
[ "PF22034" ]
[ "B129_C2H2-zf" ]
[ 39 ]
1
[]
[]
[]
0
[ "2wbt" ]
1
[]
[]
[]
[]
0
[ "IPR013087" ]
[]
1
0
1
[ "Fuselloviridae", "Sulfolobaceae" ]
[ 10, 29 ]
2
[]
[]
0
true
Domain
Uncharacterized protein B-129, C2H2 zinc finger
Uncharacterized protein B-129, C2H2 zinc finger
B129_C2H2-Znf
5
IPR054178
54,178
Lpg0393-like, VPS9-like domain
Lpg0393-like_VPS9
Domain
92
false
false
This entry represents the N-terminal domain of Lpg0393 and related proteins. Lpg0393 ( ) consists of two domains both of which are composed of α-helices. The N-terminal domain contains of seven helices and makes roughly a 90-degree angle with the C-terminal domain, that forms a helical bundle structure [ ]. The N-termi...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22035" ]
[ "Lpg0393_VPS9" ]
[ 92 ]
1
[]
[]
[]
0
[ "4r0g" ]
1
[ "PUB00091527" ]
[ "25821953" ]
[ "Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22." ]
[ 2015 ]
1
[]
[]
0
0
null
[ "Legionellales" ]
[ 92 ]
1
[]
[]
0
true
Domain
Lpg0393-like, VPS9-like domain
Lpg0393-like, VPS9-like domain
Lpg0393-like_VPS9
5
IPR054179
54,179
PSD13, N-terminal
PSD13_N
Domain
5,466
false
false
This entry represents the N-terminal domain of PSD13 from human and its orthologues from yeast, RPN9, consisting of helical repeats [ , , , ]. These proteins are a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This domain mediates interactio...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22037" ]
[ "PSD13_N" ]
[ 5466 ]
1
[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...
[ "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1236978", "R-BTA-174084", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA-2467813", "R-BTA-2871837", "R-BTA-349425", "R-BTA-350562", "R-BTA-382556", "R-BTA-450408", "R-BTA-4608870", "R-B...
[ "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-174084", "REACTOME:R-BTA-174154", "REACTOME:R-BTA-174178", "REACTOME:R-BTA-174184", "REACTOME:R-BTA-187577", "REACTOME:R-BTA-195253", "REACTOME:R-BTA-202424", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA...
316
[ "2mqw", "2mr3", "2mri", "3jck", "3jco", "3jcp", "4cr2", "4cr3", "4cr4", "5a5b", "5gjq", "5gjr", "5l4k", "5ln3", "5m32", "5mpb", "5mpc", "5mpd", "5mpe", "5t0c", "5t0g", "5t0h", "5t0i", "5t0j", "5vfp", "5vfq", "5vfr", "5vfs", "5vft", "5vfu", "5vgz", "5vhf"...
113
[ "PUB00091263", "PUB00094315", "PUB00110068", "PUB00110070", "PUB00152021" ]
[ "24706844", "25631053", "28689658", "27428775", "29636472" ]
[ "Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome.", "Solution structure of yeast Rpn9: insights into proteasome lid assembly.", "Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.", "An atomic structure of the human 26S pro...
[ 2014, 2015, 2017, 2016, 2018 ]
5
[]
[]
0
0
null
[ "Eukaryota" ]
[ 5466 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...
[ 7, 1, 2, 1, 13, 6, 1, 6, 6, 1, 1, 21 ]
12
true
Domain
PSD13, N-terminal
PSD13, N-terminal
PSD13_N
6
IPR054180
54,180
DNA-binding protein H-NS-like, N-terminal domain
H-NS-like_N
Domain
4,894
false
false
This entry corresponds to the N-terminal oligomerisation domain of H-NS histone-like proteins [ , , , ]. The histone-like nucleoid-structuring (H-NS) protein is a DNA-binding protein implicated in transcriptional repression (silencing) as well as in bacterial chromosome organisation [ ]. H-NS binds tightly to AT-rich d...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22470" ]
[ "Histone_HNS_N" ]
[ 4894 ]
1
[]
[]
[]
0
[ "1lr1", "1ni8", "1ov9", "2mw2", "3nr7", "4icg" ]
6
[ "PUB00001682", "PUB00028901", "PUB00029607", "PUB00037269", "PUB00064539", "PUB00064590" ]
[ "7875316", "12460581", "14607110", "12592399", "18387844", "20798056" ]
[ "Solution structure of the DNA binding domain of a nucleoid-associated protein, H-NS, from Escherichia coli.", "H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein.", "Crystal structure of the N-terminal dimerisation domain of VicH, the H-NS-like pro...
[ 1995, 2002, 2003, 2003, 2008, 2010 ]
6
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "metagenomes" ]
[ 4880, 10, 4 ]
3
[ "Escherichia coli (strain K12)" ]
[ 2 ]
1
true
Domain
DNA-binding protein H-NS-like, N-terminal domain
DNA-binding protein H-NS-like, N-terminal domain
H-NS-like_N
3
IPR054181
54,181
Domain of unknown function DUF6888
DUF6888
Domain
360
false
false
This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved N-terminal MPT sequence motif. AlphaFold predicts that this protein is composed of an N-terminal α-helix followed by a four stranded β-sheet. AlphaFold also predicts the protein forms a...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21828" ]
[ "DUF6888" ]
[ 360 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Cyanophyceae" ]
[ 360 ]
1
[]
[]
0
true
Domain
Domain of unknown function DUF6888
Domain of unknown function DUF6888
DUF6888
3
IPR054182
54,182
Protein of unknown function DUF6889
DUF6889
Family
362
false
false
This entry represents a family of small proteins that are largely composed of a single α-helix. Some members of the family are found on phage. The function of these proteins is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21829" ]
[ "DUF6889" ]
[ 362 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Caudoviricetes", "plant metagenome" ]
[ 343, 17, 2 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF6889
Protein of unknown function DUF6889
DUF6889
8
IPR054184
54,184
Protein of unknown function DUF6890
DUF6890
Family
259
false
false
This entry represents a family of small proteins composed largely of a single α-helix. Some proteins in this family are annotated as from phage. The function of these proteins is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21830" ]
[ "DUF6890" ]
[ 259 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Caudoviricetes", "Fusarium", "metagenomes" ]
[ 233, 11, 13, 2 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF6890
Protein of unknown function DUF6890
DUF6890
5
IPR054186
54,186
Domain of unknown function DUF6891
DUF6891
Domain
1,288
false
false
This entry represents a domain of unknown function from uncharacterised proteins mainly found in bacteria.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21831" ]
[ "DUF6891" ]
[ 1288 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriaceae", "Viruses", "ecological metagenomes" ]
[ 1193, 61, 23, 7, 4 ]
5
[]
[]
0
true
Domain
Domain of unknown function DUF6891
Domain of unknown function DUF6891
DUF6891
5
IPR054187
54,187
Domain of unknown function DUF6892
DUF6892
Domain
685
false
false
This entry represents a domain found in uncharacterised bacterial proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21832" ]
[ "DUF6892" ]
[ 685 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "ecological metagenomes" ]
[ 683, 2 ]
2
[]
[]
0
true
Domain
Domain of unknown function DUF6892
Domain of unknown function DUF6892
DUF6892
8
IPR054188
54,188
Protein of unknown function DUF6893
DUF6893
Family
351
false
false
This entry represents a family of small proteins that are likely to have a signal peptide that takes up most of the sequence. Thus, a small peptide might be released from these proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21833" ]
[ "DUF6893" ]
[ 351 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria" ]
[ 351 ]
1
[]
[]
0
true
Family
Protein of unknown function DUF6893
Protein of unknown function DUF6893
DUF6893
5
IPR054189
54,189
Domain of unknown function DUF6894
DUF6894
Domain
3,993
false
false
This entry represents a small protein domain found mainly in alphaproteobacteria. Its structure is composed of a four stranded β-sheet packed on one side by an α-helix. The function of these proteins is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21834" ]
[ "DUF6894" ]
[ 3993 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Chiloscyllium punctatum", "ecological metagenomes" ]
[ 3989, 1, 3 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6894
Domain of unknown function DUF6894
DUF6894
5
IPR054190
54,190
Domain of unknown function DUF6895
DUF6895
Domain
1,048
false
false
This entry represents a domain found in a set of uncharacterised bacterial proteins. These proteins have a predicted 6-helical hairpin fold found in a wide range of glycosyl hydrolase enzymes, suggesting a potential function.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21836" ]
[ "DUF6895" ]
[ 1048 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Halobacteriales" ]
[ 1028, 17, 3 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6895
Domain of unknown function DUF6895
DUF6895
2
IPR054191
54,191
Domain of unknown function DUF6896
DUF6896
Domain
705
false
false
This entry represents a domain found in bacterial proteins of unknown function. The domain structure includes a four stranded β-sheet which has two conserved aspartates in a DXDXG motif close to a highly conserved histidine. These three residues may for the potential active site.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21837" ]
[ "DUF6896" ]
[ 705 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria" ]
[ 705 ]
1
[]
[]
0
true
Domain
Domain of unknown function DUF6896
Domain of unknown function DUF6896
DUF6896
6
IPR054192
54,192
Protein of unknown function DUF6897
DUF6897
Family
136
false
false
This entry represents a family of small prokaryotic proteins. They are predicted to adopt an SH3-like barrel structure that shows similarity to the C-terminal domain of the ribosomal chaperone RimP .
[]
[]
[]
0
[ "PFAM" ]
[ "PF21838" ]
[ "DUF6897" ]
[ 136 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[ "IPR048163" ]
0
1
0
[ "Archaea", "Bacteria", "ecological metagenomes" ]
[ 114, 17, 5 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF6897
Protein of unknown function DUF6897
DUF6897
1
IPR054193
54,193
Domain of unknown function DUF6898
DUF6898
Domain
379
false
false
This entry represents a small protein that has a domain with a structure resembling a double stranded RNA-binding domain such as . Thus suggesting this protein may also have a dsRNA binding function. This is supported by the presence of several conserved positively charged residues.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21839" ]
[ "DUF6898" ]
[ 379 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Pseudomonadati", "metagenomes" ]
[ 371, 8 ]
2
[]
[]
0
true
Domain
Domain of unknown function DUF6898
Domain of unknown function DUF6898
DUF6898
8
IPR054195
54,195
Domain of unknown function DUF6900
DUF6900
Domain
474
false
false
This entry represents a small domain found in a range of bacterial and phage proteins. In a few proteins it is associated with . This region is composed of two α-helices.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21841" ]
[ "DUF6900" ]
[ 474 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Caudoviricetes", "metagenomes" ]
[ 469, 3, 2 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6900
Domain of unknown function DUF6900
DUF6900
1
IPR054196
54,196
Protein of unknown function DUF6901
DUF6901
Family
445
false
false
This entry represents a family of uncharacterised bacterial proteins. They contain a β-sheet packed against an α-helical subdomain. This alignment contains three fully conserved cysteines that could form an Fe-S cluster or zinc-binding site in the predicted structures.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21842" ]
[ "DUF6901" ]
[ 445 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "ecological metagenomes" ]
[ 434, 11 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6901
Protein of unknown function DUF6901
DUF6901
5
IPR054197
54,197
Protein of unknown function DUF6902
DUF6902
Family
196
false
false
This entry represents a family of bacterial proteins that have an α/α(6) toroid structure. This suggests that these proteins are probably members of an uncharacterised family of glycosyl hydrolases.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21843" ]
[ "DUF6902" ]
[ 196 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Rhodobacterales", "marine sediment metagenome" ]
[ 193, 3 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6902
Protein of unknown function DUF6902
DUF6902
9
IPR054198
54,198
Protein of unknown function DUF6903
DUF6903
Family
304
false
false
This entry represents a family of small putative bacterial integral membrane proteins with two transmembrane helices.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21844" ]
[ "DUF6903" ]
[ 304 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "metagenomes" ]
[ 302, 2 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6903
Protein of unknown function DUF6903
DUF6903
4
IPR054199
54,199
Protein of unknown function DUF6904
DUF6904
Family
451
false
false
This entry represents an uncharacterised family of bacterial proteins. Members of the family are about 250 residues in length and predicted to adopt an α/β globular structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21845" ]
[ "DUF6904" ]
[ 451 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Tanacetum cinerariifolium", "metagenomes" ]
[ 448, 1, 2 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF6904
Protein of unknown function DUF6904
DUF6904
4
IPR054200
54,200
Protein of unknown function DUF6905
DUF6905
Family
363
false
false
This entry represents a family of proteins that are annotated as Putative glycerol transporters ( ). Members of the family contain four potential transmembrane helices.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21846" ]
[ "DUF6905" ]
[ 363 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Thermococcus paralvinellae", "bioreactor metagenome" ]
[ 358, 3, 2 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF6905
Protein of unknown function DUF6905
DUF6905
3
IPR054201
54,201
Domain of unknown function DUF6906
DUF6906
Domain
386
false
false
This entry represents a small domain found in a range of phage and bacterial proteins. Structurally it is composed of a three stranded β-meander packed against an α-helix. The function of these proteins is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21847" ]
[ "DUF6906" ]
[ 386 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillota", "Viruses", "ecological metagenomes" ]
[ 338, 44, 4 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6906
Domain of unknown function DUF6906
DUF6906
9
IPR054203
54,203
Domain of unknown function DUF6908
DUF6908
Domain
326
false
false
This family of proteins are uncharacterised. This family is distantly related to currently known as DUF1249.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21849" ]
[ "DUF6908" ]
[ 326 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Caudoviricetes", "metagenomes" ]
[ 29, 279, 3, 15 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF6908
Domain of unknown function DUF6908
DUF6908
8
IPR054204
54,204
Protein of unknown function DUF6909
DUF6909
Family
1,474
false
false
This is a family of uncharacterised proteins. They are predicted to adopt a globular structure consisting of two domains. The predicted C-terminal domain share similarity with the catalytic domains of purine and uridine phosphorylases.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21850" ]
[ "DUF6909" ]
[ 1474 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanomicrobia", "ecological metagenomes" ]
[ 1363, 94, 6, 11 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF6909
Protein of unknown function DUF6909
DUF6909
4
IPR054205
54,205
Protein of unknown function DUF6911
DUF6911
Family
221
false
false
This entry represents a family of uncharacterised proteins. Proteins in this family are primarily found in Proteobacteria. The structure of these proteins contains a six stranded antiparallel β-sheet and α-helices packed on one side of the sheet.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21852" ]
[ "DUF6911" ]
[ 221 ]
1
[]
[]
[]
0
[ "6anz" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria" ]
[ 221 ]
1
[]
[]
0
true
Family
Protein of unknown function DUF6911
Protein of unknown function DUF6911
DUF6911
8
IPR054206
54,206
Protein of unknown function DUF6912
DUF6912
Family
3,516
false
false
This is a family of uncharacterised bacterial proteins. Their predicted structure shows some similarity to ADP-rybosylating toxins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21853" ]
[ "DUF6912" ]
[ 3516 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillati", "metagenomes" ]
[ 3432, 84 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6912
Protein of unknown function DUF6912
DUF6912
9
IPR054207
54,207
Protein of unknown function DUF6913
DUF6913
Family
1,146
false
false
This is a family of uncharacterised bacterial proteins. They share remote similarity to both domains of proteins members of UDP-glycosyltransferase superfamily. In contrast to them, these proteins are predicted to consist of a single standalone domain.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21857" ]
[ "DUF6913" ]
[ 1146 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "ecological metagenomes" ]
[ 1119, 27 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6913
Protein of unknown function DUF6913
DUF6913
8
IPR054208
54,208
Protein of unknown function DUF6914
DUF6914
Family
1,984
false
false
This is a family of uncharacterised eukaryotic proteins. They are predicted to adopt a globular structure that resembles the conserved core of the PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes) consisting of thiol peptidases with a circularly permuted papain-like fold.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21858" ]
[ "DUF6914" ]
[ 1984 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1984 ]
1
[]
[]
0
true
Family
Protein of unknown function DUF6914
Protein of unknown function DUF6914
DUF6914
3
IPR054209
54,209
Domain of unknown function DUF6916
DUF6916
Domain
1,344
false
false
This is a domain of unknown function found in bacterial proteins. It is predicted to adopt a RIFT-type β(6)-barrel topology with a greater similarity to FAD-binding domains.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21880" ]
[ "DUF6916" ]
[ 1344 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Fungi", "Halobacteriales", "ecological metagenomes" ]
[ 1326, 3, 4, 11 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF6916
Domain of unknown function DUF6916
DUF6916
6
IPR054210
54,210
Domain of unknown function DUF6917
DUF6917
Domain
319
false
false
This entry represents a domain in uncharacterised proteins is found in prokaryotes. Proteins in this family are typically between 135 and 154 amino acids in length. These proteins share significant sequence similarity to the central part of mammalian cell entry (MCE) protein MlaD.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21891" ]
[ "DUF6917" ]
[ 319 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "marine metagenome", "miscellaneous Crenarchaeota group-15 archaeon DG-45" ]
[ 317, 1, 1 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6917
Domain of unknown function DUF6917
DUF6917
9
IPR054211
54,211
Protein of unknown function DUF6918
DUF6918
Family
855
false
false
This is a family of uncharacterised bacterial proteins with a length of ~140-150 residues. They are predicted to adopt an α-helical structure consisting of two structural repeats.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21893" ]
[ "DUF6918" ]
[ 855 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "freshwater metagenome" ]
[ 854, 1 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6918
Protein of unknown function DUF6918
DUF6918
2
IPR054212
54,212
Domain of unknown function DUF6919
DUF6919
Domain
178
false
false
This domain is found standalone or in combination with other domains mainly from bacteria. Its function is unknown but it has a significant sequence similarity to the C-terminal SAM-binding regulatory domain of 5,10-methylenetetrahydrofolate reductase (MTHFR).
[]
[]
[]
0
[ "PFAM" ]
[ "PF21897" ]
[ "DUF6919" ]
[ 178 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Viruses", "viral metagenome" ]
[ 129, 43, 5, 1 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF6919
Domain of unknown function DUF6919
DUF6919
4
IPR054213
54,213
Protein of unknown function DUF6920
DUF6920
Family
460
false
false
This entry represents a set of uncharacterised proteins found in prokaryotes. They share remote similarity to LolA and LolB outer-membrane lipoproteins. Similar to LolA and LolB these proteins are predicted to have a hydrophobic cavity consisting of an unclosed β-barrel and an α-helical lid.
[]
[]
[]
0
[ "PFAM" ]
[ "PF21900" ]
[ "DUF6920" ]
[ 460 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 47, 394, 11, 8 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF6920
Protein of unknown function DUF6920
DUF6920
5
IPR054215
54,215
Domain of unknown function DUF6923
DUF6923
Domain
1,966
false
false
This entry represents a β-propeller domain composed of five blades. It is often found in large extracellular proteins in one or more copies. It is uncertain whether this domain might have an enzymatic function or a ligand binding function. Structurally this domain appears to have a sixfold symmetry, but one of the blad...
[]
[]
[]
0
[ "PFAM" ]
[ "PF21959" ]
[ "DUF6923" ]
[ 1966 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 1516, 435, 15 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6923
Domain of unknown function DUF6923
DUF6923
1
IPR054216
54,216
Domain of unknown function DUF6930
DUF6930
Domain
779
false
false
This domain is found C-terminal in uncharacterised bacterial proteins. It is remotely related to the integrase core domain with a partly conserved active site architecture.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22007" ]
[ "DUF6930" ]
[ 779 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriota", "ecological metagenomes" ]
[ 761, 6, 3, 9 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF6930
Domain of unknown function DUF6930
DUF6930
7
IPR054217
54,217
Domain of unknown function DUF6937
DUF6937
Domain
217
false
false
This domain is found N-terminal in a family of uncharacterised proteins. This domain has a significant sequence similarity to the N-terminal domains of a number of proteins members of UDP-Glycosyltransferase/glycogen phosphorylase superfamily. It is predicted to adopt the same α/β structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22052" ]
[ "DUF6937" ]
[ 217 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]
[ 150, 66, 1 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6937
Domain of unknown function DUF6937
DUF6937
8
IPR054218
54,218
Domain of unknown function DUF6938
DUF6938
Domain
395
false
false
This domain is found C-terminal in a family of uncharacterised proteins mainly from bacteria. This domain has a significant sequence similarity to the C-terminal domains of a number of proteins members of UDP-Glycosyltransferase/glycogen phosphorylase superfamily. It is predicted to adopt the same α/β structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22053" ]
[ "DUF6938" ]
[ 395 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Candidatus Methanodesulfokora washburnensis", "Eukaryota", "marine sediment metagenome" ]
[ 310, 1, 80, 4 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF6938
Domain of unknown function DUF6938
DUF6938
2
IPR054219
54,219
Protein of unknown function DUF6939
DUF6939
Family
296
false
false
This entry represents a family of proteins with unknown function found mainly in bacteria. They share sequence similarity with the N-terminal part of NADAR domain and are predicted to adopt structure that is globally similar to the structure of E.coli protein YbiA, a member of the NADAR domain family.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22075" ]
[ "DUF6939" ]
[ 296 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]
[ 260, 14, 17, 5 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF6939
Protein of unknown function DUF6939
DUF6939
2
IPR054220
54,220
Protein of unknown function DUF6940
DUF6940
Family
291
false
false
This is a family of uncharacterised proteins found in bacteria and eukaryotes. These proteins are probably distantly related to HIT-containing uridylyltransferases and are likely to adopt the same structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22086" ]
[ "DUF6940" ]
[ 291 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Megaviricetes", "metagenomes" ]
[ 102, 175, 7, 7 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF6940
Protein of unknown function DUF6940
DUF6940
7
IPR054221
54,221
Protein of unknown function DUF6941
DUF6941
Family
884
false
false
This is a family of uncharacterised bacterial proteins. They share sequence similarity to Ig-like domains found in a number of proteins such as xylosyltransferase, alkylpurine DNA glycosylase, cycloisomaltooligosaccharide glucanotransferase and are predicted to adopt the same structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22091" ]
[ "DUF6941" ]
[ 884 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Caudoviricetes", "metagenomes" ]
[ 808, 9, 67 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF6941
Protein of unknown function DUF6941
DUF6941
1
IPR054222
54,222
Protein of unknown function DUF6942
DUF6942
Family
456
false
false
This is a family of uncharacterised bacterial proteins. They are probably distantly related to uracil-DNA glycosylases and other related DNA glycosylases given their predicted structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22098" ]
[ "DUF6942" ]
[ 456 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "ecological metagenomes" ]
[ 453, 3 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6942
Protein of unknown function DUF6942
DUF6942
4
IPR054223
54,223
Protein of unknown function DUF6943
DUF6943
Family
397
false
false
This is a family of uncharacterised bacterial proteins. They share significant sequence similarity with each of the specificity subunit target recognition domains of type I restriction-modification enzymes and are predicted to adopt the same structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22105" ]
[ "DUF6943" ]
[ 397 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "bioreactor metagenome" ]
[ 395, 2 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6943
Protein of unknown function DUF6943
DUF6943
7
IPR054224
54,224
Protein of unknown function DUF6944
DUF6944
Family
733
false
false
This is a family of uncharacterised proteins found mainly in Gram-positive bacteria. They are predicted to be associated with the membrane and to adopt structure that has topological similarity to the common structural core of Succinate-acetate permease (SatP) superfamily proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22116" ]
[ "DUF6944" ]
[ 733 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota" ]
[ 707, 26 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6944
Protein of unknown function DUF6944
DUF6944
2
IPR054225
54,225
Domain of unknown function DUF6947
DUF6947
Domain
15
false
false
This is a domain found in a group of uncharacterised bacterial sequences whose function is unknown. This domain adopts a galactose-binding-like structure ( ).
[]
[]
[]
0
[ "PFAM" ]
[ "PF22239" ]
[ "DUF6947" ]
[ 15 ]
1
[]
[]
[]
0
[ "4lr4" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Clostridia", "human gut metagenome" ]
[ 13, 2 ]
2
[]
[]
0
true
Domain
Domain of unknown function DUF6947
Domain of unknown function DUF6947
DUF6947
8
IPR054226
54,226
Domain of unknown function DUF6948
DUF6948
Domain
103
false
false
This domain is found either as standalone or in combination with other domains in a group of uncharacterised proteins. It is distantly related to EDC3 mRNA-decapping protein 3 and it could be involved in RNA-binding. It is predicted to adopt a barrel-like structure with a typical Sm-like fold. The pair of glycines resp...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22253" ]
[ "DUF6948" ]
[ 103 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Caudoviricetes", "Methanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1)", "metagenomes" ]
[ 69, 27, 1, 6 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF6948
Domain of unknown function DUF6948
DUF6948
7
IPR054227
54,227
Protein of unknown function DUF6951
DUF6951
Family
355
false
false
This is a family of uncharacterised proteins found in archaea and bacteria. These proteins are predicted to adopt similar structure to the members of SufE/NifU superfamily. They contain three invariant cysteine residues and a fourth semi-conserved residue either cysteine or histidine. These residues are likely to defin...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22263" ]
[ "DUF6951" ]
[ 355 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "ecological metagenomes" ]
[ 192, 151, 12 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF6951
Protein of unknown function DUF6951
DUF6951
4
IPR054229
54,229
Protein of unknown function DUF6954
DUF6954
Family
89
false
false
This is a family of uncharacterised proteins from Firmicutes. They are enriched in hydrophobic residues and are likely associated with the membrane.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22268" ]
[ "DUF6954" ]
[ 89 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillota", "bioreactor metagenome" ]
[ 88, 1 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6954
Protein of unknown function DUF6954
DUF6954
9
IPR054230
54,230
Protein of unknown function DUF6955
DUF6955
Family
183
false
false
This is a family of small uncharacterised proteins found in bacteria and archaea. They are predicted to adopt an α/β globular structure consisting of a cradle-like β-sheet and α-helices packed on the convex side of the sheet.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22271" ]
[ "DUF6955" ]
[ 183 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "marine sediment metagenome" ]
[ 56, 122, 5 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF6955
Protein of unknown function DUF6955
DUF6955
9
IPR054231
54,231
Domain of unknown function DUF6956
DUF6956
Domain
628
false
false
This domain is found in uncharacterised bacterial proteins either as standalone or in combination with other domains. It is predicted to adopt an α/β structure with ferredoxin-like topology.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22273" ]
[ "DUF6956" ]
[ 628 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Pseudomonadati", "Siphoviridae sp. ctBLh2", "metagenomes" ]
[ 620, 1, 7 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6956
Domain of unknown function DUF6956
DUF6956
1
IPR054232
54,232
Domain of unknown function DUF6957
DUF6957
Domain
511
false
false
This domain is found in uncharacterised bacterial proteins. It is predicted to fold into a β-barrel that has some similarity to the replication focus targeting sequence (RFTS) domain of Dnmt1 methyltransferase 1.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22275" ]
[ "DUF6957" ]
[ 511 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Caudoviricetes", "Gammaproteobacteria", "Rhabditidae", "ecological metagenomes" ]
[ 3, 502, 3, 3 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF6957
Domain of unknown function DUF6957
DUF6957
4
IPR054233
54,233
Protein of unknown function DUF6958
DUF6958
Family
412
false
false
This family is found in uncharacterised bacterial proteins. They share sequence similarity with several HTH winged helix domains, one of which is the Zinc uptake regulation protein FurB.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22278" ]
[ "DUF6958" ]
[ 412 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 401, 7, 4 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF6958
Protein of unknown function DUF6958
DUF6958
8
IPR054234
54,234
Protein of unknown function DUF6961
DUF6961
Family
208
false
false
This is a family of small, about 60 residues in length, proteins found mainly in alphaproteobacteria. They are predicted to adopt a globular structure consisting of three helices. The N- and C-terminal helices contain highly conserved aromatic residues in addition to the nearly invariant glycines located at the interhe...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22284" ]
[ "DUF6961" ]
[ 208 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Alphaproteobacteria" ]
[ 208 ]
1
[]
[]
0
true
Family
Protein of unknown function DUF6961
Protein of unknown function DUF6961
DUF6961
7
IPR054235
54,235
Protein of unknown function DUF6962
DUF6962
Family
496
false
false
This is a family of uncharacterised proteins. They are related to HlyIII family and are predicted to adopt the same structure consisting of seven transmembrane helices. Their predicted structure, suggests that, similarly to HlyIII, they may contain a Zn-binding site, albeit slightly rearranged as only two of the Zn-coo...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22285" ]
[ "DUF6962" ]
[ 496 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Candidatus Lokiarchaeum ossiferum", "Eukaryota", "ecological metagenomes" ]
[ 401, 2, 81, 12 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF6962
Protein of unknown function DUF6962
DUF6962
2
IPR054237
54,237
Domain of unknown function DUF6964
DUF6964
Domain
18
false
false
This short helical domain is found in a small set of ribosomal S1 proteins from Rhodothermales species. It's function is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22291" ]
[ "DUF6964" ]
[ 18 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Rhodothermales" ]
[ 18 ]
1
[]
[]
0
true
Domain
Domain of unknown function DUF6964
Domain of unknown function DUF6964
DUF6964
1
IPR054238
54,238
Domain of unknown function DUF6965
DUF6965
Domain
620
false
false
This entry represents a domain found in a group of uncharacterised proteins which are predicted to form a small three helical bundle containing a β-hairpin between helices 1 and 2.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22292" ]
[ "DUF6965" ]
[ 620 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Caudoviricetes", "metagenomes" ]
[ 600, 14, 6 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6965
Domain of unknown function DUF6965
DUF6965
2
IPR054239
54,239
Domain of unknown function DUF6966
DUF6966
Domain
428
false
false
This is a domain found in uncharacterised bacterial proteins that is predicted to be helical. It contains a nearly invariant tryptophan towards the N-terminal and a highly conserved motif [F/Y]GGMGSx(2)D towards the C-terminal.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22294" ]
[ "DUF6966" ]
[ 428 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "hydrothermal vent metagenome" ]
[ 427, 1 ]
2
[]
[]
0
true
Domain
Domain of unknown function DUF6966
Domain of unknown function DUF6966
DUF6966
6
IPR054240
54,240
Protein of unknown function DUF6967
DUF6967
Family
78
false
false
This family of proteins is found in proteobacteria. Proteins in this family are approximately 70 amino acids in length. They are predicted to fold into a four-stranded β-sheet meander and an α-helix. One face of this β-sheet is enriched with conserved positively charged arginine and lysine residues.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22295" ]
[ "DUF6967" ]
[ 78 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "metagenomes" ]
[ 69, 9 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6967
Protein of unknown function DUF6967
DUF6967
9
IPR054241
54,241
Domain of unknown function DUF6968
DUF6968
Domain
634
false
false
This domain is found in uncharacterised bacterial proteins either standalone or C-terminal to HTH winged helix domains. It has a partial sequence similarity to ribosome associated factors that are members of .
[]
[]
[]
0
[ "PFAM" ]
[ "PF22302" ]
[ "DUF6968" ]
[ 634 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "ecological metagenomes" ]
[ 632, 2 ]
2
[]
[]
0
true
Domain
Domain of unknown function DUF6968
Domain of unknown function DUF6968
DUF6968
5
IPR054242
54,242
Domain of unknown function DUF6969
DUF6969
Domain
477
false
false
This domain is found in uncharacterised proteins mainly from Proteobacteria. It is predicted to adopt an α/β globular structure. It has three highly conserved histidines that are predicted to cluster together in space and are likely involved in metal coordination.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22308" ]
[ "DUF6969" ]
[ 477 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Effrenium voratum", "ecological metagenomes" ]
[ 467, 1, 9 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6969
Domain of unknown function DUF6969
DUF6969
2
IPR054243
54,243
Domain of unknown function DUF6970
DUF6970
Domain
346
false
false
This domain is found in uncharacterised proteins from bacteria and protostome animals. It is predicted to fold into a curved meander β-sheet. It contains four highly conserved cysteine residues, two of which are predicted to cluster together in space and are likely to be involved in disulfide bond formation.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22311" ]
[ "DUF6970" ]
[ 346 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Bdelloidea", "ecological metagenomes" ]
[ 313, 30, 3 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6970
Domain of unknown function DUF6970
DUF6970
9
IPR054244
54,244
Domain of unknown function DUF6971
DUF6971
Domain
44
false
false
This is a domain of unknown function found at the N-terminal end of uncharacterised proteins from Gammaproteobacteria.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22318" ]
[ "DUF6971" ]
[ 44 ]
1
[]
[]
[]
0
[ "5eur" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Gammaproteobacteria" ]
[ 44 ]
1
[]
[]
0
true
Domain
Domain of unknown function DUF6971
Domain of unknown function DUF6971
DUF6971
3
IPR054245
54,245
Domain of unknown function DUF6972
DUF6972
Domain
103
false
false
This domain is found in uncharacterised cyanobacterial proteins either standalone or in combination with other domains. It is probably distantly related to the C-terminal domain of CdiA toxin (CdiA-CT), known member of RNase A superfamily.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22319" ]
[ "DUF6972" ]
[ 103 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria" ]
[ 103 ]
1
[]
[]
0
true
Domain
Domain of unknown function DUF6972
Domain of unknown function DUF6972
DUF6972
2
IPR054246
54,246
Domain of unknown function DUF6973
DUF6973
Domain
1,641
false
false
This domain is found in uncharacterised bacterial proteins including the Putative protein RhsE . It is predicted to adopt a globular structure consisting of five α-helices. It is probably distantly related to Wnt domains.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22322" ]
[ "DUF6973" ]
[ 1641 ]
1
[]
[]
[]
0
[ "9uu0" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "uncultured Caudovirales phage" ]
[ 2, 1542, 83, 9, 5 ]
5
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Domain
Domain of unknown function DUF6973
Domain of unknown function DUF6973
DUF6973
5
IPR054248
54,248
Protein of unknown function DUF6975
DUF6975
Family
280
false
false
This family of uncharacterised proteins is found in Alphaproteobacteria. It shares significant sequence similarity with enzymes, members of Heme oxygenase-like superfamily and are predicted to adopt similar structure consisting of a bundle of six α-helices.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22391" ]
[ "DUF6975" ]
[ 280 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Alphaproteobacteria", "hydrothermal vent metagenome" ]
[ 279, 1 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6975
Protein of unknown function DUF6975
DUF6975
2
IPR054249
54,249
Protein of unknown function DUF6976
DUF6976
Family
252
false
false
This family of uncharacterised proteins is found mostly in Proteobacteria. It is likely to consists of two domains that engage in extensive contacts mainly via hydrophobic residues. The predicted structure of the N-terminal domain has similarity to chorismatases.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22396" ]
[ "DUF6976" ]
[ 252 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]
[ 247, 4, 1 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF6976
Protein of unknown function DUF6976
DUF6976
6
IPR054250
54,250
Domain of unknown function DUF6981
DUF6981
Domain
5
false
false
This entry represents an alpha-lytic protease prodomain-like domain present in a protein of unknown function from Desulfovibrio piger. Its structure has been characterised .
[]
[]
[]
0
[ "PFAM" ]
[ "PF22403" ]
[ "DUF6981" ]
[ 5 ]
1
[]
[]
[]
0
[ "4hlb" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria" ]
[ 5 ]
1
[]
[]
0
true
Domain
Domain of unknown function DUF6981
Domain of unknown function DUF6981
DUF6981
5
IPR054251
54,251
Protein of unknown function DUF6982
DUF6982
Family
195
false
false
This family of proteins is found in bacteria. Proteins in this family are typically between 135 and 1024 amino acids in length. This family of proteins are structurally related to a family of transcriptional repressors of phase-1 flagellin genes. The family appears to contain two related subdomains with SH3-like fold.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22478" ]
[ "DUF6982" ]
[ 195 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "ecological metagenomes" ]
[ 181, 14 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF6982
Protein of unknown function DUF6982
DUF6982
1
IPR054252
54,252
Cyanophage baseplate Pam3 plug gp18
Pam3_gp18
Domain
2,578
false
false
This family, previously known as DUF6983, represents Cyanophage baseplate Pam3 plug gp18 and related proteins. Gp18 has structural similarity to a component of the baseplate Complex for Myoviridae Phage XM1. The cyanophage Pam3 has a substantially simpler molecular organisation than the prototypical, contractile-tail b...
[]
[]
[]
0
[ "PFAM" ]
[ "PF22479" ]
[ "Pam3_gp18" ]
[ 2578 ]
1
[]
[]
[]
0
[ "7yfz", "8env", "8eon", "9b45", "9cuy", "9mjn" ]
6
[ "PUB00154413" ]
[ "36656854" ]
[ "Fine structure and assembly pattern of a minimal myophage Pam3." ]
[ 2023 ]
1
[]
[]
0
0
null
[ "Bacteria", "Halobacteriales", "Linnemannia gamsii", "Viruses", "metagenomes" ]
[ 1853, 5, 2, 696, 22 ]
5
[]
[]
0
true
Domain
Cyanophage baseplate Pam3 plug gp18
Cyanophage baseplate Pam3 plug gp18
Pam3_gp18
3
IPR054253
54,253
Domain of unknown function DUF6984
DUF6984
Domain
351
false
false
This entry represents a bacterial family of unknown function. They are predicted to adopt a globular α/β structure.
[]
[]
[]
0
[ "PFAM" ]
[ "PF22480" ]
[ "DUF6984" ]
[ 351 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Knufia peltigerae", "bioreactor metagenome" ]
[ 349, 1, 1 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF6984
Domain of unknown function DUF6984
DUF6984
5