LiteFold/InterPro · Datasets at Hugging Face

IPR053912

53,912

PGAP2IP, first transmembrane domain

PGAP2IP_TM_1nd

Domain

2,523

false

This domain is found in the human PGAP2-interacting protein (PGAP2IP) and its homologues in yeast CWH43. PGAP2IP is composed of three domains. Two of these domains are predicted to adopt very similar structure consisting of six transmembrane helices, which suggests a possible duplication event in these proteins. These ...

[]

0

[ "PFAM" ]

[ "PF23022" ]

[ "6TM_1st_PGAP2IP" ]

[ 2523 ]

1

[]

0

[]

0

[ "PUB00063839" ]

[ "17761529" ]

[ "Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2523 ]

1

[ "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 5, 1, 1, 5, 1, 1 ]

6

true

Domain

PGAP2IP, first transmembrane domain

PGAP2IP_TM_1nd

9

IPR053913

53,913

DarT1-associated NADAR antitoxin

NADAR-DarT1

Family

404

false

This entry, previously known as DUF6977, represents DarT1-associated NADAR antitoxin and related proteins. The DarT-NADAR system is a TA system catalysing the specific and reversible ADP-ribosylation of guanosine bases in which DarT1-associated NADARs reverse guanine ADP-ribosylation catalysed by DarT1. DarT1-associate...

[]

0

[ "PFAM" ]

[ "PF22397" ]

[ "NADAR-DarT1" ]

[ 404 ]

1

[]

0

[ "8bat" ]

1

[ "PUB00154386" ]

[ "37390817" ]

[ "Molecular basis for the reversible ADP-ribosylation of guanosine bases." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 397, 7 ]

2

[]

0

true

Family

DarT1-associated NADAR antitoxin

NADAR-DarT1

9

IPR053914

53,914

Dispersed gene family protein 1, N-terminal domain

DGF-1_N

Domain

1,408

false

This entry represents the N-terminal domain present in DGF-1 (Dispersed gene family protein 1) from Trypanosoma, one of the most abundant proteins in T. cruzi genome [ ]. It seems to have a preferential expression in amastigotes (intracellular replicative forms that develop in the mammalian host) [ ]. The function of t...

[]

0

[ "PFAM" ]

[ "PF22279" ]

[ "DGF-1_N" ]

[ 1408 ]

1

[]

0

[]

0

[ "PUB00153905", "PUB00153906" ]

[ "36839564", "19841080" ]

[ "The Elusive Trypanosoma cruzi Disperse Gene Protein Family (DGF-1).", "Localization and developmental regulation of a dispersed gene family 1 protein in Trypanosoma cruzi." ]

[ 2023, 2010 ]

2

[]

0

null

[ "Metakinetoplastina" ]

[ 1408 ]

1

[]

0

true

Domain

Dispersed gene family protein 1, N-terminal domain

DGF-1_N

5

IPR053915

53,915

Dispersed gene family protein 1, beta-sheet domain

DGF-1_b-sheet_dom

Domain

1,368

false

This entry represents a β-sheet domain present in DGF-1 from Trypanosoma proteins, one of the most abundant proteins in T. cruzi genome [ ]. This domain adopts a pectin lyase-like fold. The function of this protein is not yet clear, however, it is likely to play a role in cell-to-cell interactions or signal transductio...

[]

0

[ "PFAM" ]

[ "PF22274" ]

[ "DGF-1_beta-sheet" ]

[ 1368 ]

1

[]

0

[]

0

[ "PUB00153905" ]

[ "36839564" ]

[ "The Elusive Trypanosoma cruzi Disperse Gene Protein Family (DGF-1)." ]

[ 2023 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1368 ]

1

[]

0

true

Domain

Dispersed gene family protein 1, beta-sheet domain

DGF-1_b-sheet_dom

7

IPR053916

53,916

Protein of unknown function DUF6978

DUF6978

Family

450

false

This is a family of uncharacterised proteins. They are predicted to adopt a globular α/β structure consisting of a meander β-sheet and two α-helices packed on one side on the sheet. These proteins contain three highly conserved histidines that in the predicted structure cluster close in space and could potentially form...

[]

0

[ "PFAM" ]

[ "PF22398" ]

[ "DUF6978" ]

[ 450 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Methanobacteriota", "Rhizophagus irregularis", "metagenomes" ]

[ 427, 4, 13, 1, 5 ]

5

[]

0

true

Family

Protein of unknown function DUF6978

DUF6978

2

IPR053917

53,917

Protein of unknown function DUF6979

DUF6979

Family

208

false

This is a family of uncharacterised proteins. They are predicted to fold into a globular structure consisting mainly of α-helices.

[]

0

[ "PFAM" ]

[ "PF22399" ]

[ "DUF6979" ]

[ 208 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Escherichia phage 4A7", "Methanomicrobia" ]

[ 205, 1, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF6979

DUF6979

3

IPR053918

53,918

Domain of unknown function DUF6980

DUF6980

Domain

347

false

This is a domain found in uncharacterised bacterial proteins. This domain occurs either standalone or in combination with other domains. It contains conserved cysteines and histidine that may be involved in Zn2 coordination.

[]

0

[ "PFAM" ]

[ "PF22400" ]

[ "DUF6980" ]

[ 347 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Glomeromycetes", "Peduoviridae", "hydrothermal vent metagenome" ]

[ 336, 7, 3, 1 ]

4

[]

0

true

Domain

Domain of unknown function DUF6980

DUF6980

6

IPR053919

53,919

Treslin, N-terminal domain

Treslin_N

Domain

920

false

This entry represents the N-terminal domain of Treslin, the metazoan counterpart of Sld3 from yeast, which are the hub proteins mediating protein associations critical for the helicase formation [ , ]. Treslin, as Sld3, interacts with TopBP1 in a Cdk2-dependent manner, which then collaborate in the Cdk2-mediated loadin...

[]

0

[ "PFAM" ]

[ "PF21854" ]

[ "Treslin_N" ]

[ 920 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-69273", "R-HSA-69273", "R-MMU-69273" ]

[ "REACTOME:R-DRE-69273", "REACTOME:R-HSA-69273", "REACTOME:R-MMU-69273" ]

3

[]

0

[ "PUB00103954", "PUB00103961", "PUB00103962" ]

[ "35091422", "25126958", "22380713" ]

[ "Refining the domain architecture model of the replication origin firing factor Treslin/TICRR.", "Crystal structure of the homology domain of the eukaryotic DNA replication proteins Sld3/Treslin.", "Treslin, DUE-B, and GEMC1 cannot complement Sld3 mutants in fission yeast." ]

[ 2022, 2014, 2012 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 920 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 6, 2 ]

4

true

Domain

Treslin, N-terminal domain

Treslin_N

3

IPR053920

53,920

Treslin, STD domain

Treslin_STD

Domain

1,036

false

This entry represents the STD (Sld3-Treslin domain) domain from Treslin, the metazoan counterpart of Sld3 from yeast, which are the hub proteins mediating protein associations critical for the helicase formation [ , ]. Treslin, as Sld3, interacts with TopBP1 in a Cdk2-dependent manner, which then collaborate in the Cdk...

[]

0

[ "PFAM" ]

[ "PF21855" ]

[ "Treslin_STD" ]

[ 1036 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-69273", "R-HSA-69273", "R-MMU-69273" ]

[ "REACTOME:R-DRE-69273", "REACTOME:R-HSA-69273", "REACTOME:R-MMU-69273" ]

3

[]

0

[ "PUB00103954", "PUB00103961", "PUB00103962" ]

[ "35091422", "25126958", "22380713" ]

[ "Refining the domain architecture model of the replication origin firing factor Treslin/TICRR.", "Crystal structure of the homology domain of the eukaryotic DNA replication proteins Sld3/Treslin.", "Treslin, DUE-B, and GEMC1 cannot complement Sld3 mutants in fission yeast." ]

[ 2022, 2014, 2012 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1036 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 4, 3 ]

5

true

Domain

Treslin, STD domain

Treslin_STD

6

IPR053923

53,923

Replication protein RepB, C-terminal domain

RepB_C

Domain

539

false

This entry represents the C-terminal oligomerisation domain (OD) of plasmid replication proteins, such as RepB. These proteins are essential for replication of plasmids, the Rep proteins are topoisomerases that nick the positive stand at the plus origin of replication and also at the single-strand conversion sequence [...

[]

0

[ "PFAM" ]

[ "PF21861" ]

[ "RepB_C" ]

[ 539 ]

1

[]

0

[]

0

[ "PUB00097405", "PUB00154199", "PUB00160031" ]

[ "26875695", "36688326", "17267412" ]

[ "Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158.", "Structures of pMV158 replication initiator RepB with and without DNA reveal a flexible dual-function protein.", "Interactions between the RepB initiator protein of plasmid pMV158 and two distant...

[ 2016, 2023, 2007 ]

3

[]

0

null

[ "Bacteria", "Ecdysozoa", "Inoviridae", "uncultured prokaryote" ]

[ 498, 5, 2, 34 ]

4

[]

0

true

Domain

Replication protein RepB, C-terminal domain

RepB_C

2

IPR053924

53,924

RecX, second three-helical domain

RecX_HTH_2nd

Domain

20,444

false

This entry represents the second three-helical domain (HTH-like) found in RecX family of proteins. RecX functions as a regulator of DNA recombination and repair pathways in bacterial cells [ ]. RecX protein is known to inhibit the activity of RecA protein in DNA recombination [ , ]. It contains three HTH-like domains, ...

[]

0

[ "PFAM" ]

[ "PF02631" ]

[ "RecX_HTH2" ]

[ 20444 ]

1

[]

0

[ "3c1d", "3d5l", "3dfg", "3e3v" ]

4

[ "PUB00050856", "PUB00154197", "PUB00154198" ]

[ "18650935", "23284295", "35730924" ]

[ "Structural basis for inhibition of homologous recombination by the RecX protein.", "RecX facilitates homologous recombination by modulating RecA activities.", "A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions." ]

[ 2008, 2012, 2022 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctj8j9", "unclassified sequences" ]

[ 19528, 585, 1, 330 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 4, 7 ]

4

true

Domain

RecX, second three-helical domain

RecX_HTH_2nd

3

IPR053925

53,925

RecX, third three-helical domain

RecX_HTH_3rd

Domain

17,668

false

This entry represents the third three-helical domain (HTH-like) found in RecX family of proteins. RecX functions as a regulator of DNA recombination and repair pathways in bacterial cells [ ]. RecX protein is known to inhibit the activity of RecA protein in DNA recombination [ , ]. It contains three HTH-like domains, f...

[]

0

[ "PFAM" ]

[ "PF21981" ]

[ "RecX_HTH3" ]

[ 17668 ]

1

[]

0

[ "3c1d", "3d5l", "3dfg", "3e3v" ]

4

[ "PUB00050856", "PUB00154197", "PUB00154198" ]

[ "18650935", "23284295", "35730924" ]

[ "Structural basis for inhibition of homologous recombination by the RecX protein.", "RecX facilitates homologous recombination by modulating RecA activities.", "A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions." ]

[ 2008, 2012, 2022 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 16948, 438, 282 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 4, 7 ]

4

true

Domain

RecX, third three-helical domain

RecX_HTH_3rd

9

IPR053926

53,926

RecX, first three-helical domain

RecX_HTH_1st

Domain

14,807

false

This entry represents the first three-helix domain (HTH-like) found in RecX family of proteins. RecX functions as a regulator of DNA recombination and repair pathways in bacterial cells [ ]. RecX protein is known to inhibit the activity of RecA protein in DNA recombination [ , ]. It contains three HTH-like domains, fir...

[]

0

[ "PFAM" ]

[ "PF21982" ]

[ "RecX_HTH1" ]

[ 14807 ]

1

[]

0

[ "3c1d", "3d5l", "3dfg", "3e3v" ]

4

[ "PUB00050856", "PUB00154197", "PUB00154198" ]

[ "18650935", "23284295", "35730924" ]

[ "Structural basis for inhibition of homologous recombination by the RecX protein.", "RecX facilitates homologous recombination by modulating RecA activities.", "A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions." ]

[ 2008, 2012, 2022 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctj8j9", "unclassified sequences" ]

[ 14218, 344, 1, 244 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Zea mays" ]

[ 4, 1, 6 ]

3

true

Domain

RecX, first three-helical domain

RecX_HTH_1st

8

IPR053927

53,927

Flagellar hook-associated protein FlgK, helical domain

FlgK_helical

Domain

14,278

false

This entry represents a mainly helical domain found in flagellar hook-associated protein FlgK (also called Flagellar hook-associated protein 1) and related proteins mostly from bacteria. FlgK is one of three hook associated proteins that form the hook-filament junction. This domain adopts a broken antiparallel helical ...

[]

0

[ "PFAM" ]

[ "PF22638" ]

[ "FlgK_D1" ]

[ 14278 ]

1

[]

0

[ "2d4y", "4ut1", "5xbj", "9go6", "9gsx" ]

5

[ "PUB00076713", "PUB00153951" ]

[ "25645451", "29147015" ]

[ "From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook-associated protein FlgK.", "Structure of FlgK reveals the divergence of the bacterial Hook-Filament Junction of Campylobacter." ]

[ 2015, 2017 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14095, 33, 150 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Flagellar hook-associated protein FlgK, helical domain

FlgK_helical

6

IPR053928

53,928

Nonstructural protein NS-S, N-terminal, bunyaviral

NS-S_N_bunyaviral

Domain

605

false

This entry represents the N-terminal domain of Nonstructural protein NS-S from the tospovirus Tomato spotted wilt virus and related sequences from related Bunyavirales. Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein....

[]

0

[ "PFAM" ]

[ "PF03231" ]

[ "Tospov_NS-S_N" ]

[ 605 ]

1

[]

0

[]

0

[ "PUB00034463", "PUB00034464", "PUB00034465", "PUB00034466", "PUB00034467", "PUB00154426", "PUB00154427" ]

[ "1826573", "8445364", "11209062", "12133999", "12829839", "12502849", "31206553" ]

[ "The nonstructural protein (NSs) encoded by the ambisense S RNA segment of tomato spotted wilt virus is associated with fibrous structures in infected plant cells.", "Multiplication of tomato spotted wilt virus in its insect vector, Frankliniella occidentalis.", "Bunyamwera bunyavirus nonstructural protein NSs ...

[ 1991, 1993, 2001, 2002, 2003, 2003, 2019 ]

7

[]

0

null

[ "Viruses" ]

[ 605 ]

1

[]

0

true

Domain

Nonstructural protein NS-S, N-terminal, bunyaviral

NS-S_N_bunyaviral

6

IPR053929

53,929

Nonstructural protein NS-S, WIV domain, bunyaviral

NS-S_WIV_bunyaviral

Domain

568

false

This entry represents the WIV domain [ ] of Nonstructural protein NS-S from the tospovirus Tomato spotted wilt virus and related sequences from related Bunyavirales. Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. Th...

[]

0

[ "PFAM" ]

[ "PF23017" ]

[ "WIV_2" ]

[ 568 ]

1

[]

0

[]

0

[ "PUB00034463", "PUB00034464", "PUB00034465", "PUB00034466", "PUB00034467", "PUB00154424", "PUB00154426", "PUB00154427" ]

[ "1826573", "8445364", "11209062", "12133999", "12829839", "38193819", "12502849", "31206553" ]

[ "The nonstructural protein (NSs) encoded by the ambisense S RNA segment of tomato spotted wilt virus is associated with fibrous structures in infected plant cells.", "Multiplication of tomato spotted wilt virus in its insect vector, Frankliniella occidentalis.", "Bunyamwera bunyavirus nonstructural protein NSs ...

[ 1991, 1993, 2001, 2002, 2003, 2024, 2003, 2019 ]

8

[]

0

null

[ "Bunyaviricetes" ]

[ 568 ]

1

[]

0

true

Domain

Nonstructural protein NS-S, WIV domain, bunyaviral

NS-S_WIV_bunyaviral

1

IPR053930

53,930

RapZ-like, N-terminal domain

RapZ-like_N

Domain

17,895

false

This entry represents the N-terminal P-loop kinase domain of RNase adapter protein RapZ and related proteins. RapZ plays a central role in RNA-mediated regulation of amino-sugar metabolism [ , , ]. It is a RNA-binding protein that recruits the major endoribonuclease RNase E to sRNAs GlmZ [ , ].

[]

0

[ "PFAM" ]

[ "PF03668" ]

[ "RapZ-like_N" ]

[ 17895 ]

1

[]

0

[ "5o5o", "5o5q", "8b0i", "8b0j", "9m1q", "9m1v" ]

6

[ "PUB00075613", "PUB00150969", "PUB00153826" ]

[ "23475961", "28977623", "36968430" ]

[ "Targeted decay of a regulatory small RNA by an adaptor protein for RNase E and counteraction by an anti-adaptor RNA.", "Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism.", "New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic proces...

[ 2013, 2017, 2023 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 17519, 19, 357 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

RapZ-like, N-terminal domain

RapZ-like_N

5

IPR053931

53,931

RapZ, C-terminal domain

RapZ_C

Domain

19,546

false

This entry represents the C-terminal domain of RapZ which belongs to the Rhodanese-Phosphatase superfamily. It has been shown to bind multiple ligands as part of the regulation of glucosamine-6-phosphate (GlcN6P) levels, which is a precursor to the bacterial cell wall polymer peptidoglycan. Assignment to the greater Rh...

[]

0

[ "PFAM" ]

[ "PF22740" ]

[ "PapZ_C" ]

[ 19546 ]

1

[]

0

[ "5o5o", "5o5q", "5o5s", "8b0i", "8b0j" ]

5

[ "PUB00153826" ]

[ "36968430" ]

[ "New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 18709, 419, 26, 392 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

RapZ, C-terminal domain

RapZ_C

9

IPR053933

53,933

Glabrous enhancer-binding protein-like, C-terminal domain

GeBP-like_C

Domain

531

false

This entry represents the C-terminal domain present in GLABROUS1 enhancer-binding protein (GeBP) and GeBP-like proteins, such as storekeeper and storekeeper-like (STKL) transcription factors. GeBP and GeBP-like proteins play a redundant role in cytokinin hormone pathway regulation [ , , ]. Storekeeper was identified as...

[]

0

[ "PFAM" ]

[ "PF22757" ]

[ "GeBP-like_C" ]

[ 531 ]

1

[]

0

[]

0

[ "PUB00081457", "PUB00081459", "PUB00081460", "PUB00153966", "PUB00153967" ]

[ "18162594", "27031427", "12028578", "12535344", "35890483" ]

[ "GeBP and GeBP-like proteins are noncanonical leucine-zipper transcription factors that regulate cytokinin response in Arabidopsis.", "Regulation of Arabidopsis thaliana plasma membrane glucose-responsive regulator (AtPGR) expression by A. thaliana storekeeper-like transcription factor, AtSTKL, modulates glucose ...

[ 2008, 2016, 2002, 2003, 2022 ]

5

[]

0

null

[ "Eukaryota" ]

[ 531 ]

1

[ "Arabidopsis thaliana" ]

[ 53 ]

1

true

Domain

Glabrous enhancer-binding protein-like, C-terminal domain

GeBP-like_C

3

IPR053934

53,934

HTTM domain

HTTM_dom

Domain

4,753

false

This entry represents the HTTM (for horizontally transferred transmembrane) domain found at the N-terminal in metazoan Vitamin K-dependent gamma-carboxylase and in diverse domain architectures in bacterial proteins. This domain contains four transmembrane regions [ ].

[]

0

[ "PFAM" ]

[ "PF05090" ]

[ "HTTM" ]

[ 4753 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.1.1.90", "PWY-7999", "R-BTA-159740", "R-HSA-159740", "R-HSA-9673240", "R-MMU-159740", "R-RNO-159740" ]

[ "EC:4.1.1.90", "METACYC:PWY-7999", "REACTOME:R-BTA-159740", "REACTOME:R-HSA-159740", "REACTOME:R-HSA-9673240", "REACTOME:R-MMU-159740", "REACTOME:R-RNO-159740" ]

7

[ "9bum", "9bur", "9bux", "9bvk", "9bvl", "9bvm", "9bvo", "9bvp", "9bvq", "9bvr", "9l1y", "9l20", "9l21", "9l23", "9l24", "9l25", "9l54", "9l6q", "9l6r", "9l6s", "9mqb", "9mqc", "9mqe" ]

23

[ "PUB00010243", "PUB00055033", "PUB00154019" ]

[ "10748045", "12817086", "14729325" ]

[ "Identification of a Drosophila vitamin K-dependent gamma-glutamyl carboxylase.", "Cannibalism by sporulating bacteria.", "HTTM, a horizontally transferred transmembrane domain." ]

[ 2000, 2003, 2004 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 266, 2737, 1723, 27 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 16, 6, 7 ]

5

true

Domain

HTTM domain

HTTM_dom

9

IPR053935

53,935

Vitamin K-dependent gamma-carboxylase, lumenal domain

VKGC_lumenal_dom

Domain

3,239

false

Using reduced vitamin K, oxygen, and carbon dioxide, gamma-glutamyl carboxylase (VKGC) post-translationally modifies certain glutamates by adding carbon dioxide to the gamma position of those amino acids. In vertebrates, the modification of glutamate residues of target proteins is facilitated by an interaction between ...

[]

0

[ "PFAM" ]

[ "PF22777" ]

[ "VKGC_lumenal_dom" ]

[ 3239 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.1.1.90", "PWY-7999", "R-BTA-159740", "R-HSA-159740", "R-HSA-9673240", "R-MMU-159740", "R-RNO-159740" ]

[ "EC:4.1.1.90", "METACYC:PWY-7999", "REACTOME:R-BTA-159740", "REACTOME:R-HSA-159740", "REACTOME:R-HSA-9673240", "REACTOME:R-MMU-159740", "REACTOME:R-RNO-159740" ]

7

[ "9bum", "9bur", "9bux", "9bvk", "9bvl", "9bvm", "9bvo", "9bvp", "9bvq", "9bvr", "9l1y", "9l20", "9l21", "9l23", "9l24", "9l25", "9l54", "9l6q", "9l6r", "9l6s", "9mqb", "9mqc", "9mqe" ]

23

[ "PUB00010243", "PUB00154019" ]

[ "10748045", "14729325" ]

[ "Identification of a Drosophila vitamin K-dependent gamma-glutamyl carboxylase.", "HTTM, a horizontally transferred transmembrane domain." ]

[ 2000, 2004 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Nitrosopumilus maritimus (strain SCM1)", "metagenomes" ]

[ 1635, 1582, 1, 21 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 11, 4, 4 ]

5

true

Domain

Vitamin K-dependent gamma-carboxylase, lumenal domain

VKGC_lumenal_dom

3

IPR053936

53,936

Wntless, GOLD domain

WLS_GOLD

Domain

2,156

false

This entry represents the GOLD domain from wntless (WLS) proteins. WLS are membrane trafficking and secretion chaperones for lipidated Wnt signaling proteins. They are homologous to GPR180, TMEM145, and TMEM181, which have been described as GOST proteins (for GOLD domain seven-transmembrane helix proteins) together wit...

[]

0

[ "PFAM" ]

[ "PF21883" ]

[ "WLS_GOLD" ]

[ 2156 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-3238698", "R-DME-3238698", "R-HSA-3238698", "R-MMU-3238698", "R-RNO-3238698" ]

[ "REACTOME:R-CEL-3238698", "REACTOME:R-DME-3238698", "REACTOME:R-HSA-3238698", "REACTOME:R-MMU-3238698", "REACTOME:R-RNO-3238698" ]

5

[ "7drt", "7kc4", "8tzo", "8tzp", "8tzr", "8tzs" ]

6

[ "PUB00151072" ]

[ "36373655" ]

[ "Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A." ]

[ 2022 ]

1

[]

0

null

[ "Metazoa" ]

[ 2156 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 10, 2, 3 ]

6

true

Domain

Wntless, GOLD domain

WLS_GOLD

6

IPR053937

53,937

GOST, seven transmembrane domain

GOST_TM

Domain

12,844

false

This entry represents the transmembrane domain of a group of related proteins that share the same domain architecture, termed GOST (GOLD domain seven-transmembrane helix) proteins, including TMEM87A/B, GPR107/GPR108 from human and the homologues from yeast, PTM1 [ ]. This entry also includes plant proteins, CAND6/7 [ ]...

[]

0

[ "PFAM" ]

[ "PF06814" ]

[ "GOST_TM" ]

[ 12844 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-8980692", "R-MMU-8980692" ]

[ "REACTOME:R-HSA-8980692", "REACTOME:R-MMU-8980692" ]

2

[ "8ctj", "8hsi", "8htt", "8kb4" ]

4

[ "PUB00151072", "PUB00153986" ]

[ "36373655", "33878345" ]

[ "Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A.", "A G protein-coupled receptor-like module regulates cellulose synthase secretion from the endomembrane system in Arabidopsis." ]

[ 2022, 2021 ]

2

[]

0

null

[ "Eukaryota" ]

[ 12844 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 39, 2, 13, 2, 26, 12, 1, 29, 14, 2, 2, 75 ]

12

true

Domain

GOST, seven transmembrane domain

GOST_TM

1

IPR053938

53,938

PTM1-like, N-terminal domain

PTM1-like_N

Domain

1,768

false

This entry represents the N-terminal domain of fungal proteins, such as PTM1 from S.cerevisiae and its closely homologues from S.pombe. They have been identified as orthologues of TMEM87A/B from human. Structure predictions suggest that these proteins has the same domain architecture as GOST (GOLD seven-transmembrane h...

[]

0

[ "PFAM" ]

[ "PF21902" ]

[ "PTM1-like_N" ]

[ 1768 ]

1

[]

0

[]

0

[ "PUB00035466", "PUB00151072" ]

[ "16107716", "36373655" ]

[ "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments.", "Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A." ]

[ 2005, 2022 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1768 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 2 ]

3

true

Domain

PTM1-like, N-terminal domain

PTM1-like_N

4

IPR053939

53,939

UTP25, C-terminal domain

UTP25_C

Domain

4,652

false

UTP25 is a family of eukaryotic proteins. The family displays limited sequence similarity to DEAD-box RNA helicases, having alternative residues at the Walker A and DEAD-box sites, but conservation of structural and other key residues [ ]. This entry represents the C-terminal domain that is required and sufficient for ...

[]

0

[ "PFAM" ]

[ "PF06862" ]

[ "Utp25_C" ]

[ 4652 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

6

[]

0

[ "PUB00074620", "PUB00109164" ]

[ "21941128", "20884785" ]

[ "The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae.", "The DEAD-box RNA helicase-like Utp25 is an SSU processome component." ]

[ 2011, 2010 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4652 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 3, 3, 2, 1, 3, 3, 1, 1, 7 ]

12

true

Domain

UTP25, C-terminal domain

UTP25_C

1

IPR053940

53,940

UTP25, NTP hydrolase-like domain

UTP25_NTPase-like

Domain

4,976

false

UTP25 (U3 small nucleolar RNA-associated protein 25) is a DEAD-box RNA helicase-like protein component of the ribosomal small subunit processome for the biogenesis of ribosomes, which functions in pre-ribosomal RNA (pre-rRNA) processing [ ]. U3 small nucleolar RNA-associated protein 25 homologue (UTP25, also known as D...

[]

0

[ "PFAM" ]

[ "PF22916" ]

[ "UTP25_NTPase-like" ]

[ 4976 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

6

[]

0

[ "PUB00074620", "PUB00097919", "PUB00097921", "PUB00097922", "PUB00109164" ]

[ "21941128", "25007945", "27657329", "23357851", "20884785" ]

[ "The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae.", "MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease.", "Phosphorylation of Def Regula...

[ 2011, 2014, 2016, 2013, 2010 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4976 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 3, 4, 3, 1, 4, 3, 1, 1, 7 ]

12

true

Domain

UTP25, NTP hydrolase-like domain

UTP25_NTPase-like

6

IPR053941

53,941

Csm6, HEPN domain

Csm6_HEPN

Domain

539

false

This entry represents the HEPN domain of CRISPR system endoribonuclease Csm6 from Enterococcus italicus and similar bacterial sequences. Csm6 is a Cas (CRISPR-associated) protein from type III-A CRISPR-Cas system. It consists of a CARF domain at the N-terminal ( ), a six-helix domain and a C-terminal HEPN domain at the...

[]

0

[ "PFAM" ]

[ "PF09659" ]

[ "Cas_Csm6_HEPN" ]

[ 539 ]

1

[]

0

[ "4rgp", "5yjc", "6tug", "8pcw", "8pe3" ]

5

[ "PUB00153857" ]

[ "32221291" ]

[ "Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Methanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)", "bioreactor metagenome" ]

[ 537, 1, 1 ]

3

[]

0

true

Domain

Csm6, HEPN domain

Csm6_HEPN

3

IPR053943

53,943

Ribosomal RNA large subunit methyltransferase K/L-like, conserved site

RlmKL-like_Mtase_CS

Conserved_site

11,962

false

This entry represents a conserved site found in ribosomal RNA large subunit methyltransferase K/L from Escherichia coli (RmlKL) and related proteins. RmlKL specifically methylates the guanine in positions 2445 and 2069 of 23S rRNA before its assembly into 50S subunits [ , , , ]. This conserved site is defined by a D-P-...

[]

0

[ "PROSITE" ]

[ "PS01261" ]

[ "UPF0020" ]

[ 11962 ]

1

[ "EC", "EC", "EC" ]

[ "2.1.1", "2.1.1.173", "2.1.1.264" ]

[ "EC:2.1.1", "EC:2.1.1.173", "EC:2.1.1.264" ]

3

[ "3k0b", "3ldu", "3tlj", "3tm4", "3tm5", "3v8v", "3v97", "6zxv", "6zxw", "6zxy" ]

10

[ "PUB00039897", "PUB00100798", "PUB00100799" ]

[ "16343540", "22362734", "17010378" ]

[ "Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain.", "Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA.", "Identification of Escherichia coli m2G methyl...

[ 2006, 2012, 2006 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ct9mC1", "metagenomes" ]

[ 546, 9950, 1345, 1, 120 ]

5

[ "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 2, 1, 3 ]

5

true

Conserved_site

Ribosomal RNA large subunit methyltransferase K/L-like, conserved site

RlmKL-like_Mtase_CS

5

IPR053944

53,944

Shieldin complex subunit 2, second OB fold domain

SHLD2_OB2

Domain

816

false

This entry represents the second OB fold domain found in the middle of Shieldin complex subunit 2 (SHLD2, formerly known as FAM35A) and in similar sequences mainly found in vertebrates. SHLD2 is a component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) [ , ]. In s...

[]

0

[ "PFAM" ]

[ "PF22779" ]

[ "OB_SHLD2_2nd" ]

[ 816 ]

1

[]

0

[]

0

[ "PUB00089626", "PUB00101857" ]

[ "29656893", "29789392" ]

[ "DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.", "FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells." ]

[ 2018, 2018 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 816 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 3, 5 ]

4

true

Domain

Shieldin complex subunit 2, second OB fold domain

SHLD2_OB2

2

IPR053945

53,945

Phosphoinositide phospholipase C beta 1-4-like, EF-hand domain

PLCB1-4-like_EFh

Domain

7,213

false

This entry represents the first EF-hand domain found in 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-4 (PLCB1-4) from human and related animal proteins. PLC-beta isoforms mediate the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) to propagate...

[]

0

[ "PFAM" ]

[ "PF22631" ]

[ "PLCB1-4-like_EFh" ]

[ 7213 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...

[ "3.1.4.11", "PWY-6351", "PWY-6367", "PWY-7039", "PWY-8052", "R-BTA-112043", "R-BTA-1855204", "R-BTA-399997", "R-BTA-4086398", "R-BTA-416476", "R-BTA-418217", "R-BTA-434316", "R-BTA-500657", "R-CEL-112043", "R-CEL-1855204", "R-CEL-416476", "R-DME-112043", "R-DME-1855204", "R-DME-3...

[ "EC:3.1.4.11", "METACYC:PWY-6351", "METACYC:PWY-6367", "METACYC:PWY-7039", "METACYC:PWY-8052", "REACTOME:R-BTA-112043", "REACTOME:R-BTA-1855204", "REACTOME:R-BTA-399997", "REACTOME:R-BTA-4086398", "REACTOME:R-BTA-416476", "REACTOME:R-BTA-418217", "REACTOME:R-BTA-434316", "REACTOME:R-BTA-5006...

46

[ "2fju", "2zkm", "3qr0", "3qr1", "4gnk", "4qj3", "4qj4", "4qj5", "7sq2", "8emv", "8emw", "8emx", "8uqn", "8uqo" ]

14

[ "PUB00040695", "PUB00093065", "PUB00112989", "PUB00137701", "PUB00137702" ]

[ "17115053", "23377541", "21822282", "25435326", "20966218" ]

[ "Crystal structure of Rac1 bound to its effector phospholipase C-beta2.", "Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain.", "An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation.", "Molecular mechanisms of phosph...

[ 2006, 2013, 2011, 2014, 2010 ]

5

[]

[ "IPR028400", "IPR046969" ]

0

2

0

[ "Eumetazoa" ]

[ 7213 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 23, 19, 4, 37, 19, 24 ]

6

true

Domain

Phosphoinositide phospholipase C beta 1-4-like, EF-hand domain

PLCB1-4-like_EFh

3

IPR053946

53,946

YscD-like, Bon-like domain 3

YscD_ppl_3rd

Domain

1,187

false

This entry represents the third of three periplasmic BON domains. YscD is a single-pass inner membrane protein required for the export process of the Yop proteins. It is an essential component of the type III secretion system. YscD contains an N-terminal cytoplasmic domain ( ), a transmembrane linker and a large peripl...

[]

0

[ "PFAM" ]

[ "PF21934" ]

[ "Yop-YscD_ppl_3rd" ]

[ 1187 ]

1

[]

0

[ "4alz" ]

1

[ "PUB00020581", "PUB00076172" ]

[ "1860816", "23908767" ]

[ "Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica.", "In situ structural analysis of the Yersinia enterocolitica injectisome." ]

[ 1991, 2013 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "invertebrate metagenome" ]

[ 1183, 3, 1 ]

3

[]

0

true

Domain

YscD-like, Bon-like domain 3

YscD_ppl_3rd

4

IPR053947

53,947

YscD-like, Bon-like domain 2

YscD_ppl__2nd

Domain

992

false

This entry represents the second of three periplasmic BON domains in YscD proteins from proteobacteria. YscD is a single-pass inner membrane protein required for the export process of the Yop proteins. It is an essential component of the type III secretion system. YscD contains an N-terminal cytoplasmic domain ( ), a t...

[]

0

[ "PFAM" ]

[ "PF21937" ]

[ "Yop-YscD_ppl_2nd" ]

[ 992 ]

1

[]

0

[ "4alz" ]

1

[ "PUB00020581", "PUB00076172" ]

[ "1860816", "23908767" ]

[ "Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica.", "In situ structural analysis of the Yersinia enterocolitica injectisome." ]

[ 1991, 2013 ]

2

[]

0

null

[ "Bacteria", "Bracon brevicornis", "invertebrate metagenome" ]

[ 990, 1, 1 ]

3

[]

0

true

Domain

YscD-like, Bon-like domain 2

YscD_ppl__2nd

5

IPR053948

53,948

SBE2/SBE22, N-terminal domain

SBE2/SBE22_N

Domain

95

false

This entry represents a domain found at the N-terminal of SBE2 and its paralogue, SBE22 from budding yeast. These proteins are involved in bud growth and yeast cell wall formation [ ]. They may be also involved in the transport of cell wall components from the Golgi apparatus to the cell surface periphery [ ].

[]

0

[ "PFAM" ]

[ "PF22876" ]

[ "SBE2_N" ]

[ 95 ]

1

[]

0

[]

0

[ "PUB00075790", "PUB00114131" ]

[ "10679005", "12045225" ]

[ "Sbe2p and sbe22p, two homologous Golgi proteins involved in yeast cell wall formation.", "Mechanisms for targeting of the Saccharomyces cerevisiae GPI-anchored cell wall protein Crh2p to polarised growth sites." ]

[ 2000, 2002 ]

2

[]

0

null

[ "Saccharomycotina" ]

[ 95 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Domain

SBE2/SBE22, N-terminal domain

SBE2/SBE22_N

7

IPR053949

53,949

SBE2/SBE22, middle domain

SBE2/SBE22_M

Domain

1,051

false

This entry represents a domain found central in SBE2, its paralogue, SBE22 from budding yeast, and similar proteins from ascomycetes. These proteins are involved in bud growth and yeast cell wall formation [ ]. They may be also involved in the transport of cell wall components from the Golgi apparatus to the cell surfa...

[]

0

[ "PFAM" ]

[ "PF22874" ]

[ "SBE2_M" ]

[ 1051 ]

1

[]

0

[]

0

[ "PUB00075790", "PUB00114131" ]

[ "10679005", "12045225" ]

[ "Sbe2p and sbe22p, two homologous Golgi proteins involved in yeast cell wall formation.", "Mechanisms for targeting of the Saccharomyces cerevisiae GPI-anchored cell wall protein Crh2p to polarised growth sites." ]

[ 2000, 2002 ]

2

[]

0

null

[ "saccharomyceta" ]

[ 1051 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 2 ]

2

true

Domain

SBE2/SBE22, middle domain

SBE2/SBE22_M

2

IPR053950

53,950

CAP, N-terminal domain

CAP_N

Domain

6,586

false

Cyclase-associated proteins (CAPs) are highly conserved actin-binding proteins present in a wide range of organisms including yeast, fly, plants, and mammals. CAPs are multifunctional proteins that regulate actin remodelling in response to cellular signals [ ]. They consist of an N-terminal conserved motif ( ) followed...

[]

0

[ "PFAM" ]

[ "PF21938" ]

[ "CAP_N" ]

[ 6586 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6798695", "R-HSA-114608", "R-HSA-428890", "R-HSA-6798695", "R-MMU-6798695", "R-RNO-6798695", "R-SCE-6798695", "R-SPO-6798695" ]

[ "REACTOME:R-DDI-6798695", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-428890", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-6798695", "REACTOME:R-SCE-6798695", "REACTOME:R-SPO-6798695" ]

8

[ "1s0p", "1tjf", "6rsq", "6rsw" ]

4

[ "PUB00022651", "PUB00031477", "PUB00153848" ]

[ "12962635", "15558566", "31757941" ]

[ "Structure of the N-terminal domain of the adenylyl cyclase-associated protein (CAP) from Dictyostelium discoideum.", "Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP).", "Mechanism of synergistic actin filament pointed end depolymerization by cyclase...

[ 2003, 2005, 2019 ]

3

[]

0

null

[ "Eukaryota" ]

[ 6586 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 4, 3, 3, 23, 10, 1, 6, 9, 1, 1, 21 ]

12

true

Domain

CAP, N-terminal domain

CAP_N

5

IPR053951

53,951

K+ potassium transporter, integral membrane domain

K_trans_N

Domain

28,232

false

This is a family of K+ potassium transporters that are conserved across phyla, including bacterial (KUP) [ ], yeast (HAK) [ ], and plant (AtKT) [ ]. This entry represents the N-terminal integral membrane domain.

[]

0

[ "PFAM" ]

[ "PF02705" ]

[ "K_trans" ]

[ 28232 ]

1

[]

0

[]

0

[ "PUB00007570", "PUB00007571", "PUB00007572" ]

[ "8226635", "7621817", "9350997" ]

[ "Nucleotide sequence and 3'-end deletion studies indicate that the K(+)-uptake protein kup from Escherichia coli is composed of a hydrophobic core linked to a large and partially essential hydrophilic C terminus.", "A potassium transporter of the yeast Schwanniomyces occidentalis homologous to the Kup system of E...

[ 1993, 1995, 1997 ]

3

[]

0

null

[ "Bacteria", "Chlorovirus", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 12768, 2, 15293, 50, 119 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 59, 1, 1, 65, 234 ]

5

true

Domain

K+ potassium transporter, integral membrane domain

K_trans_N

8

IPR053952

53,952

K+ potassium transporter, C-terminal domain

K_trans_C

Domain

26,179

false

This is a family of K+ potassium transporters that are conserved across phyla, including bacterial (KUP) [ ], yeast (HAK) [ ], and plant (AtKT) [ ]. This entry represents the C-terminal non-membrane domain.

[]

0

[ "PFAM" ]

[ "PF22776" ]

[ "K_trans_C" ]

[ 26179 ]

1

[]

0

[]

0

[ "PUB00007570", "PUB00007571", "PUB00007572" ]

[ "8226635", "7621817", "9350997" ]

[ "Nucleotide sequence and 3'-end deletion studies indicate that the K(+)-uptake protein kup from Escherichia coli is composed of a hydrophobic core linked to a large and partially essential hydrophilic C terminus.", "A potassium transporter of the yeast Schwanniomyces occidentalis homologous to the Kup system of E...

[ 1993, 1995, 1997 ]

3

[]

0

null

[ "Bacteria", "Chlorovirus", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 12549, 2, 13462, 47, 119 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 60, 1, 1, 1, 55, 194 ]

6

true

Domain

K+ potassium transporter, C-terminal domain

K_trans_C

4

IPR053953

53,953

Siroheme decarboxylase NirL-like, HTH domain

NirdL-like_HTH

Domain

4,947

false

This entry represents the helix-turn-helix (HTH) domain found in siroheme decarboxylase NirdL from Hydrogenobacter thermophilus and related sequences, from bacteria and archaea [ , , , , ]. NirdL is involved in heme d1 biosynthesis. It catalyses the decarboxylation of siroheme into didecarboxysiroheme.

[]

0

[ "PFAM" ]

[ "PF22451" ]

[ "NirdL-like_HTH" ]

[ 4947 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "4.1.1.111", "PWY-7552", "PWY-7554" ]

[ "EC:4.1.1.111", "METACYC:PWY-7552", "METACYC:PWY-7554" ]

3

[ "4ch7", "4czc", "4czd", "4un1" ]

4

[ "PUB00014071", "PUB00022604", "PUB00050396", "PUB00059696", "PUB00154102" ]

[ "11230123", "14976242", "19004003", "21338611", "25083922" ]

[ "Crystal structure of the Lrp-like transcriptional regulator from the archaeon Pyrococcus furiosus.", "The archaeal feast/famine regulatory protein: potential roles of its assembly forms for regulating transcription.", "Interactions between the archaeal transcription repressor FL11 and its coregulators lysine a...

[ 2001, 2004, 2009, 2011, 2014 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Metazoa", "unclassified sequences" ]

[ 922, 3882, 8, 135 ]

4

[]

0

true

Domain

Siroheme decarboxylase NirL-like, HTH domain

NirdL-like_HTH

5

IPR053954

53,954

Domain of unknown function DUF7023

DUF7023

Domain

966

false

This domain is found in human Protein dispatched homolog 3 (DISP3) and related proteins mainly from vertebrates. DISP3 (PTCHD2), a sterol-sensing domain- containing protein, is highly expressed in neural tissue, promotes cell proliferation and alters expression of genes that are involved in tumorigenesis. The function ...

[]

0

[ "PFAM" ]

[ "PF22894" ]

[ "DUF7023" ]

[ 966 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chordata" ]

[ 966 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 2, 2 ]

4

true

Domain

Domain of unknown function DUF7023

DUF7023

8

IPR053955

53,955

Csm6, CARF domain

Csm6_CARF

Domain

256

false

This entry represents the CARF domain of CRISPR system endoribonuclease Csm6 from Enterococcus italicus and similar bacterial sequences. Csm6 is a Cas (CRISPR-associated) protein from type III-A CRISPR-Cas system. It consists of a CARF domain at the N-terminal, a six-helix domain and a C-terminal HEPN domain at the C-t...

[]

0

[ "PFAM" ]

[ "PF22208" ]

[ "Cas_Csm6_CARF" ]

[ 256 ]

1

[]

0

[ "6tug", "8pcw", "8pe3" ]

3

[ "PUB00153857" ]

[ "32221291" ]

[ "Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Methanobrevibacter millerae", "bioreactor metagenome" ]

[ 254, 1, 1 ]

3

[]

0

true

Domain

Csm6, CARF domain

Csm6_CARF

9

IPR053956

53,956

NPC1, middle luminal domain

NPC1_MLD

Domain

7,601

false

NPC intracellular cholesterol transporter 1 (NPC1) is a endosomal/lysosomal membrane protein that facilitates the trafficking of cholesterol and other cargo from lysosomes and is involved in cholesterol homeostasis [ , , , ]. Mutations in the NPC1 gene cause the rare neurodegenerative disease Niemann-Pick Type C (NPC)....

[]

0

[ "PFAM" ]

[ "PF22314" ]

[ "NPC1_MLD" ]

[ 7601 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-8963678", "R-CEL-8964038", "R-DME-8963678", "R-HSA-8963678", "R-HSA-8964038", "R-MMU-8963678", "R-MMU-8964038", "R-RNO-8963678", "R-SCE-8963678", "R-SCE-8964038" ]

[ "REACTOME:R-CEL-8963678", "REACTOME:R-CEL-8964038", "REACTOME:R-DME-8963678", "REACTOME:R-HSA-8963678", "REACTOME:R-HSA-8964038", "REACTOME:R-MMU-8963678", "REACTOME:R-MMU-8964038", "REACTOME:R-RNO-8963678", "REACTOME:R-SCE-8963678", "REACTOME:R-SCE-8964038" ]

10

[ "3jd8", "5f18", "5f1b", "5hns", "5jnx", "5kwy", "5u73", "5u74", "6r4l", "6uox", "6v3f", "6v3h", "6w5r", "6w5s", "6w5t", "6w5u", "6w5v", "7df8", "7dfw", "7dfz", "7n4u", "7n4v", "7n4x", "8eus", "8qeb", "8qec", "8qed", "8qee", "9dz2" ]

29

[ "PUB00154113", "PUB00154114", "PUB00154115", "PUB00154116", "PUB00154117" ]

[ "31543266", "26771495", "26846330", "27551080", "28784760" ]

[ "Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.", "Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1.", "Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.", "Clues to the mechanism of chole...

[ 2019, 2016, 2016, 2016, 2017 ]

5

[]

0

null

[ "Eukaryota" ]

[ 7601 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 2, 8, 5, 11, 7, 1, 4, 6, 1, 6 ]

11

true

Domain

NPC1, middle luminal domain

NPC1_MLD

5

IPR053957

53,957

DUF2089, zinc ribbon

DUF2089_Zn_ribbon

Domain

1,382

false

This entry represents the zinc ribbon found at the N-terminal of a group of hypothetical prokaryotic proteins that often contain ( ). In some members, it occurs as a fusion of ZnR+HTH+SHOCT-like.

[]

0

[ "PFAM" ]

[ "PF22747" ]

[ "Zn_ribbon_DUF2089" ]

[ 1382 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacterium", "ecological metagenomes" ]

[ 1347, 2, 9, 24 ]

4

[]

0

true

Domain

DUF2089, zinc ribbon

DUF2089_Zn_ribbon

8

IPR053958

53,958

HMGCR/SNAP/NPC1-like, sterol-sensing domain

HMGCR/SNAP/NPC1-like_SSD

Domain

24,045

false

This entry represents the sterol-sensing domain found in a group of proteins related to cholesterol metabolism and transport, such as HMG-CoA reductase (HMGCR), Sterol regulatory element-binding protein cleavage-activating protein (SCAP), NPC1, patched and related proteins, which are membrane-bound transcription factor...

[]

0

[ "PFAM" ]

[ "PF12349" ]

[ "Sterol-sensing" ]

[ 24045 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-191273", "R-CEL-5632684", "R-CEL-8963678", "R-CEL-8964038", "R-DME-191273", "R-DME-209338", "R-DME-209471", "R-DME-5610787", "R-DME-5632681", "R-DME-5632684", "R-DME-8963678", "R-HSA-1655829", "R-HSA-191273", "R-HSA-1989781", "R-HSA-2426168", "R-HSA-373080", "R-HSA-5610787", ...

[ "REACTOME:R-BTA-191273", "REACTOME:R-CEL-5632684", "REACTOME:R-CEL-8963678", "REACTOME:R-CEL-8964038", "REACTOME:R-DME-191273", "REACTOME:R-DME-209338", "REACTOME:R-DME-209471", "REACTOME:R-DME-5610787", "REACTOME:R-DME-5632681", "REACTOME:R-DME-5632684", "REACTOME:R-DME-8963678", "REACTOME:R-...

39

[ "3jd8", "5jnx", "5u73", "5u74", "6dmb", "6dmo", "6dmy", "6e1h", "6m49", "6mg8", "6n7g", "6n7h", "6n7k", "6oeu", "6oev", "6r4l", "6rmg", "6rvd", "6tbu", "6td6", "6uox", "6v3f", "6v3h", "6w5r", "6w5s", "6w5t", "6w5u", "6w5v", "6xe6", "7df8", "7dfw", "7dfz"...

57

[ "PUB00062075", "PUB00109796", "PUB00109797", "PUB00152323", "PUB00154366", "PUB00154389" ]

[ "12482938", "9488713", "17604677", "9242699", "29954986", "27238017" ]

[ "Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols.", "Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies.", ...

[ 2002, 1998, 2007, 1997, 2018, 2016 ]

6

[ "IPR000731" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriati", "ecological metagenomes" ]

[ 67, 23964, 2, 12 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 9, 23, 12, 33, 22, 3, 4, 28, 3, 2, 6 ]

12

true

Domain

HMGCR/SNAP/NPC1-like, sterol-sensing domain

HMGCR/SNAP/NPC1-like_SSD

8

IPR053959

53,959

YvlB/LiaX, N-terminal domain

YvlB/LiaX_N

Domain

2,802

false

This entry represents a small domain found at the N-terminal of the uncharacterised protein YvlB from Bacillus subtilis, the putative adhesin domain-containing protein LiaX from Enterococcus faecalis and similar prokaryotic sequences. In some members, this domain occurs as a fusion of ZnR+DUF2089-HTH+SHOCT-like, where ...

[]

0

[ "PFAM" ]

[ "PF22746" ]

[ "SHOCT-like_DUF2089-C" ]

[ 2802 ]

1

[]

0

[]

0

[ "PUB00105524" ]

[ "31818937" ]

[ "Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis." ]

[ 2019 ]

1

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 13, 2763, 26 ]

3

[]

0

true

Domain

YvlB/LiaX, N-terminal domain

YvlB/LiaX_N

4

IPR053961

53,961

XRCC4, N-terminal domain

XRCC4_N

Domain

2,113

false

This represents the N-terminal β-sandwich domain of a family consisting of several eukaryotic DNA double-strand break repair and V(D)J recombination protein XRCC4 sequences. In the non-homologous end joining pathway of DNA double-strand break repair, the ligation step is catalysed by a complex of XRCC4 and DNA ligase I...

[]

0

[ "PFAM" ]

[ "PF06632" ]

[ "XRCC4" ]

[ 2113 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-5693571", "R-HSA-164843", "R-HSA-3108214", "R-HSA-5693571", "R-MMU-3108214", "R-MMU-5693571" ]

[ "REACTOME:R-DDI-5693571", "REACTOME:R-HSA-164843", "REACTOME:R-HSA-3108214", "REACTOME:R-HSA-5693571", "REACTOME:R-MMU-3108214", "REACTOME:R-MMU-5693571" ]

6

[ "1fu1", "1ik9", "3ii6", "3mud", "3q4f", "3rwr", "3sr2", "3w03", "4xa4", "5chx", "5cj0", "5cj4", "5wj7", "5wlz", "6abo", "7lsy", "7lt3", "7m3p", "7nfc", "7nfe", "8bh3", "8bhv", "8bhy", "8bot", "8eza", "8ezb", "9cq3", "9cq6", "9cqc", "9gd7", "9n81", "9n82"...

33

[ "PUB00012766", "PUB00147236", "PUB00154391" ]

[ "12517771", "10757784", "15385968" ]

[ "Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.", "Ku recruits the XRCC4-ligase IV complex to DNA ends.", "Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV." ]

[ 2003, 2000, 2004 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2113 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 2, 1, 1, 5, 3, 7, 4 ]

8

true

Domain

XRCC4, N-terminal domain

XRCC4_N

9

IPR053962

53,962

XRCC4, coiled-coil domain

XRCC4_CC

Domain

1,923

false

This entry represents the dimeric coiled-coil region from the XRCC4 protein. The complex of two proteins, XRCC4 and DNA ligase IV, plays a fundamental role in DNA non-homologous end joining (NHEJ), a cellular function required for double-strand break repair and V(D)J recombination [ ]. The BRCT domains of DNA ligase IV...

[]

0

[ "PFAM" ]

[ "PF21924" ]

[ "XRCC4_CC" ]

[ 1923 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-164843", "R-HSA-3108214", "R-HSA-5693571", "R-MMU-3108214", "R-MMU-5693571" ]

[ "REACTOME:R-HSA-164843", "REACTOME:R-HSA-3108214", "REACTOME:R-HSA-5693571", "REACTOME:R-MMU-3108214", "REACTOME:R-MMU-5693571" ]

5

[ "1fu1", "1ik9", "3ii6", "3q4f", "3rwr", "3sr2", "3w03", "4xa4", "5cj0", "5cj4", "6abo", "7lsy", "7lt3", "7m3p", "7nfc", "7nfe", "8bh3", "8bhv", "8bhy", "8bot", "8eza", "8ezb", "9cq3", "9cq6", "9cqc", "9gd7", "9n81", "9n82", "9n83" ]

29

[ "PUB00012766", "PUB00013254", "PUB00147236", "PUB00154391" ]

[ "12517771", "11702069", "10757784", "15385968" ]

[ "Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.", "Crystal structure of an Xrcc4-DNA ligase IV complex.", "Ku recruits the XRCC4-ligase IV complex to DNA ends.", "Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligat...

[ 2003, 2001, 2000, 2004 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1923 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 3, 1, 3, 7, 2 ]

7

true

Domain

XRCC4, coiled-coil domain

XRCC4_CC

2

IPR053963

53,963

XRCC4, C-terminal domain

XRCC4_C

Domain

794

false

This entry represents the C-terminal disordered region from the XRCC4 protein. This domain acts as an activator of the phospholipid scramblase activity of XKR4 [ ]. Upon apoptotic stimuli, XRCC4 is cleaved by caspases, and its C-terminal fragment with an intrinsically disordered region is released into the cytoplasm. T...

[]

0

[ "PFAM" ]

[ "PF21925" ]

[ "XRCC4_C" ]

[ 794 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-164843", "R-HSA-3108214", "R-HSA-5693571", "R-MMU-3108214", "R-MMU-5693571" ]

[ "REACTOME:R-HSA-164843", "REACTOME:R-HSA-3108214", "REACTOME:R-HSA-5693571", "REACTOME:R-MMU-3108214", "REACTOME:R-MMU-5693571" ]

5

[ "7lsy", "7lt3", "7nfc", "7nfe", "8bh3", "8bhv", "8bhy", "8bot", "8eza", "8ezb", "9cq3", "9cq6", "9cqc", "9gd7", "9n81", "9n82", "9n83" ]

17

[ "PUB00012766", "PUB00147236", "PUB00154390", "PUB00154391" ]

[ "12517771", "10757784", "33725486", "15385968" ]

[ "Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.", "Ku recruits the XRCC4-ligase IV complex to DNA ends.", "Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.", "Xrcc4 physicall...

[ 2003, 2000, 2021, 2004 ]

4

[]

0

null

[ "Gnathostomata" ]

[ 794 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 3, 7 ]

4

true

Domain

XRCC4, C-terminal domain

XRCC4_C

9

IPR053964

53,964

Integrator complex subunit 1, R3 domain

INT1_R3

Domain

1,806

false

Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. It binds the C-terminal domain (CTD) of RNA polymerase II (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription of both prote...

[]

0

[ "PFAM" ]

[ "PF22927" ]

[ "INT1_R3" ]

[ 1806 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6807505", "R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-DDI-6807505", "REACTOME:R-DME-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

4

[ "7cun", "7pks", "7ycx", "8rbx", "8rbz", "8rc4", "8yjb", "9vd9" ]

8

[ "PUB00152015" ]

[ "33243860" ]

[ "Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase." ]

[ 2020 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1806 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 3, 4, 4 ]

5

true

Domain

Integrator complex subunit 1, R3 domain

INT1_R3

2

IPR053965

53,965

Integrator complex subunit 1, R4 domain

INTS1_R4

Domain

1,732

false

Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. It binds the C-terminal domain (CTD) of RNA polymerase II (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription of both prote...

[]

0

[ "PFAM" ]

[ "PF22928" ]

[ "INTS1_R4" ]

[ 1732 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6807505", "R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-DDI-6807505", "REACTOME:R-DME-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

4

[ "7cun", "7pks", "7ycx", "8rbx", "8rbz", "8rc4", "8yjb", "9vd9" ]

8

[ "PUB00152015" ]

[ "33243860" ]

[ "Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase." ]

[ 2020 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1732 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 4, 3, 2 ]

6

true

Domain

Integrator complex subunit 1, R4 domain

INTS1_R4

6

IPR053967

53,967

Flagellar hook protein FlgE/F/G-like, D1 domain

LlgE_F_G-like_D1

Domain

38,062

false

This entry represents the D1 domain found in three closely related flagellar proteins, usually denoted FlgE, FlgF and FlgG and related proteins. In FlgE, there is an additional domain D2 ( ) outside D1 [ , , , , ]. The flagellar hook is a short, highly curved tubular structure that connects the flagellar motor to the l...

[]

0

[ "PFAM" ]

[ "PF22692" ]

[ "LlgE_F_G_D1" ]

[ 38062 ]

1

[]

0

[ "1wlg", "2bgy", "2bgz", "3a69", "5az4", "5jxl", "5npy", "5wrh", "6jf2", "6jzr", "6jzt", "6k3i", "6k9q", "6kfk", "6ndx", "7bin", "7cbm", "7cgb", "7cgo", "7e80", "7e82", "7nvg", "8wk3", "8wki", "8wkk", "8wl2", "8wlh", "8wlp", "8wlq", "8wlt", "8wo5", "8woe"...

39

[ "PUB00032756", "PUB00106064", "PUB00151809", "PUB00154040", "PUB00154041" ]

[ "15657146", "27759043", "27811912", "19913483", "29083539" ]

[ "A partial atomic structure for the flagellar hook of Salmonella typhimurium.", "Structural insights into bacterial flagellar hooks similarities and specificities.", "Complete structure of the bacterial flagellar hook reveals extensive set of stabilizing interactions.", "Specific arrangement of alpha-helical ...

[ 2005, 2016, 2016, 2009, 2017 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 37573, 69, 2, 418 ]

4

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

Flagellar hook protein FlgE/F/G-like, D1 domain

LlgE_F_G-like_D1

7

IPR053968

53,968

BF9343_1606-like, C-terminal

BF9343_1606-like_C

Domain

25

false

This domain is found at the C-terminal of BF9343_1606 from Bacteroides fragilis ( ). This domain, whose structure has been solved ( ), is associated with .

[]

0

[ "PFAM" ]

[ "PF22452" ]

[ "BF9343_1606-like_C" ]

[ 25 ]

1

[]

0

[ "3g3l" ]

1

[]

0

[]

0

null

[ "Bacteroides" ]

[ 25 ]

1

[]

0

true

Domain

BF9343_1606-like, C-terminal

BF9343_1606-like_C

5

IPR053969

53,969

Gag1-like, lock domain

Lock_Gag1-like

Domain

40

false

This domain found in Gag1 from Saccharomyces cerevisiae and similar fungal sequences. Gag1 interacts with Cka2, the fourth subunit of the eukaryotic kinase CK2. This protein is organised into three domains: lock (this entry), Gag and Clamp ( ) [ ]. This short domain is predicted to adopt a predominantly α-helical confi...

[]

0

[ "PFAM" ]

[ "PF22991" ]

[ "Lock_Gag1-like" ]

[ 40 ]

1

[]

0

[]

0

[ "PUB00153176" ]

[ "37968396" ]

[ "The social and structural architecture of the yeast protein interactome." ]

[ 2023 ]

1

[]

0

null

[ "Saccharomycetaceae" ]

[ 40 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Gag1-like, lock domain

Lock_Gag1-like

9

IPR053970

53,970

RavZ, C-terminal PI3P-binding domain

RavZ_C

Domain

16

false

This entry represents the C-terminal in RavZ proteins. The intracellular pathogen Legionella pneumophila interferes with autophagy by delivering an effector protein, cysteine protease RavZ, into the host cytosol. This effector protein cleaves membrane-conjugated Atg8/LC3 proteins from pre-autophagosomal structures [ , ...

[]

0

[ "PFAM" ]

[ "PF22225" ]

[ "RavZ_C" ]

[ 16 ]

1

[]

0

[ "5cqc", "5hzy", "5io3", "5izv", "5ms2", "5ms7", "5ms8" ]

7

[ "PUB00154191", "PUB00154192", "PUB00154193", "PUB00154418" ]

[ "26343456", "27791457", "28395732", "32686895" ]

[ "The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs.", "The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane.", "Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ us...

[ 2015, 2017, 2017, 2020 ]

4

[]

0

null

[ "Legionella" ]

[ 16 ]

1

[]

0

true

Domain

RavZ, C-terminal PI3P-binding domain

RavZ_C

7

IPR053971

53,971

CofB-like, beta-repeat domain

CofB-like_b-rpt_dom

Domain

24

false

CofB is a minor pilin involved in type IV pili assembly. It consists of a pilin domain at the N-terminal ( ), followed by a β-repeat hinge-like domain and a C-terminal β-sheet-rich lectin domain [ , ]. This entry represents the central β-repeat domain which has two three-stranded anti-parallel β-sheets [ , ].

[]

0

[ "PFAM" ]

[ "PF22228" ]

[ "CofB_beta-rpt" ]

[ 24 ]

1

[]

0

[ "4qs4", "5ax6", "5ypz" ]

3

[ "PUB00151800", "PUB00151801" ]

[ "26324721", "26876601" ]

[ "Crystal Structure of the Minor Pilin CofB, the Initiator of CFA/III Pilus Assembly in Enterotoxigenic Escherichia coli.", "Homo-trimeric Structure of the Type IVb Minor Pilin CofB Suggests Mechanism of CFA/III Pilus Assembly in Human Enterotoxigenic Escherichia coli." ]

[ 2015, 2016 ]

2

[]

0

null

[ "Bacteria" ]

[ 24 ]

1

[]

0

true

Domain

CofB-like, beta-repeat domain

CofB-like_b-rpt_dom

8

IPR053972

53,972

CofB, C-terminal domain

CofB_C

Domain

101

false

CofB is a minor pilin involved in type IV pili assembly. It consists of a pilin domain at the N-terminal ( ), followed by a β-repeat hinge-like domain ( ) and a C-terminal β-sheet-rich domain, similar to H-type lectins [ , ]. This entry represents the C-terminal domain which is required for CofB to initiate pilus assem...

[]

0

[ "PFAM" ]

[ "PF22229" ]

[ "CofB_C" ]

[ 101 ]

1

[]

0

[ "4qs4", "5ax6", "5ypz", "6mic" ]

4

[ "PUB00151800", "PUB00151801" ]

[ "26324721", "26876601" ]

[ "Crystal Structure of the Minor Pilin CofB, the Initiator of CFA/III Pilus Assembly in Enterotoxigenic Escherichia coli.", "Homo-trimeric Structure of the Type IVb Minor Pilin CofB Suggests Mechanism of CFA/III Pilus Assembly in Human Enterotoxigenic Escherichia coli." ]

[ 2015, 2016 ]

2

[]

0

null

[ "Bacteria" ]

[ 101 ]

1

[]

0

true

Domain

CofB, C-terminal domain

CofB_C

2

IPR053973

53,973

Endoplasmic reticulum metallopeptidase 1-like, C-terminal domain

ERMP1-like_C

Domain

3,576

false

Endoplasmic reticulum metallopeptidase 1 (ERMP1, also known as Felix-ina, FXNA or Fxna peptidase) is a multi-pass membrane protein located in the endoplasmic reticulum membrane. In humans, it may play a crucial role in processing proteins required for the organisation of somatic cells and oocytes into discrete follicul...

[]

0

[ "PFAM" ]

[ "PF22248" ]

[ "ERMP1_C" ]

[ 3576 ]

1

[]

0

[]

0

[ "PUB00116354", "PUB00153927" ]

[ "17267443", "24498434" ]

[ "Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis.", "Structural and functional characterization of cargo-binding sites on the μ4-subunit of adaptor protein complex 4." ]

[ 2007, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3576 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 11, 2, 1, 24, 10, 1, 4, 6, 11 ]

9

true

Domain

Endoplasmic reticulum metallopeptidase 1-like, C-terminal domain

ERMP1-like_C

4

IPR053974

53,974

Endoplasmic reticulum metallopeptidase 1/1-A, TM domain

ERMP1_1-A_TM

Domain

2,735

false

Endoplasmic reticulum metallopeptidase 1 (ERMP1, also known as Felix-ina, FXNA or Fxna peptidase) is a multi-pass membrane protein located in the endoplasmic reticulum membrane. In humans, it may play a crucial role in processing proteins required for the organisation of somatic cells and oocytes into discrete follicul...

[]

0

[ "PFAM" ]

[ "PF22249" ]

[ "ERMP1-TM" ]

[ 2735 ]

1

[]

0

[]

0

[ "PUB00116354" ]

[ "17267443" ]

[ "Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2735 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 17, 12, 2, 7 ]

6

true

Domain

Endoplasmic reticulum metallopeptidase 1/1-A, TM domain

ERMP1_1-A_TM

3

IPR053975

53,975

Vacuolar membrane protease, C-terminal domain

PFF1_C

Domain

1,483

false

This entry includes fungal vacuolar membrane proteases, such as PFF1 from yeast, which may be involved in vacuolar sorting and osmoregulation [ ]. It is an homologue of human ERMP1 [ ]. According to AlphaFold structure predictions, these proteins consist of a M28 peptidase domain ( ) at the N-terminal, a central transm...

[]

0

[ "PFAM" ]

[ "PF22250" ]

[ "PFF1_C" ]

[ 1483 ]

1

[]

0

[]

0

[ "PUB00101324", "PUB00151250" ]

[ "35175277", "23679341" ]

[ "A lysosomal biogenesis map reveals the cargo spectrum of yeast vacuolar protein targeting pathways.", "Characterization of an M28 metalloprotease family member residing in the yeast vacuole." ]

[ 2022, 2013 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1483 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

Vacuolar membrane protease, C-terminal domain

PFF1_C

3

IPR053977

53,977

Thioredoxin-like reductase Rv2466c-like

Rv2466c-like

Family

5,946

false

This entry represents a family of proteins mainly found in actinomycetes, including thioredoxin-like reductase Rv2466c from Mycobacterium tuberculosis. Rv2466c is a key oxidoreductase that mediates the reductive activation of TP053, a thienopyrimidine derivative that kills replicating and non-replicating M.tuberculosis...

[]

0

[ "PFAM" ]

[ "PF22234" ]

[ "Rv2466c-like" ]

[ 5946 ]

1

[]

0

[ "4nxi", "4wkw", "4zil", "5xur" ]

4

[ "PUB00154217", "PUB00154218", "PUB00154219" ]

[ "26546681", "24877756", "29465985" ]

[ "The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.", "Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.", "Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis." ]

[ 2015, 2014, 2018 ]

3

[]

0

null

[ "Bacteria", "Rhynchospora breviuscula", "metagenomes" ]

[ 5804, 1, 141 ]

3

[]

0

true

Family

Thioredoxin-like reductase Rv2466c-like

Rv2466c-like

1

IPR053978

53,978

SO2946-like, C-terminal domain

SO2946-like_C

Domain

33

false

This entry represents the C-terminal domain of SO2946 from Shewanella oneidensis ( ). This protein consists of a short helical N-terminal domain and a large C-terminal domain with the jelly-roll topology, identified as a putative carbohydrate-binding module [ ]. This domain can also be found in other regions in bacteri...

[]

0

[ "PFAM" ]

[ "PF22237" ]

[ "SO2946-like_C" ]

[ 33 ]

1

[]

0

[ "2a5z" ]

1

[ "PUB00047012" ]

[ "18566914" ]

[ "Structure of SO2946 orphan from Shewanella oneidensis shows \"jelly-roll\" fold with carbohydrate-binding module." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 18, 4, 11 ]

3

[]

0

true

Domain

SO2946-like, C-terminal domain

SO2946-like_C

4

IPR053980

53,980

Type ISP restriction-modification enzyme, coupler domain

ISP_coupler

Domain

1,584

false

Type ISP restriction-modification (RM) enzymes cleave random DNA between distant target sites when two enzymes collide following convergent ATP-driven translocation. This entry represents the all-helical coupler domain of type ISP RM enzymes, which links the ATPase to the MTase and the C-terminal TRD (target recognitio...

[]

0

[ "PFAM" ]

[ "PF22240" ]

[ "ISP_coupler" ]

[ 1584 ]

1

[]

0

[ "4xqk", "5ffj", "7lo5", "7lvv" ]

4

[ "PUB00091657", "PUB00154025", "PUB00154026" ]

[ "26389736", "26975655", "33826880" ]

[ "Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes.", "Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes.", "Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme vis...

[ 2015, 2016, 2021 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "Siphoviridae sp. ctBLh2", "metagenomes" ]

[ 3, 1558, 5, 1, 17 ]

5

[]

0

true

Domain

Type ISP restriction-modification enzyme, coupler domain

ISP_coupler

6

IPR053981

53,981

Baseplate hub protein gp44/GpP-like, second domain

Gp44/GpP-like_2nd

Domain

2,308

false

This domain is found in baseplate hub protein gp44 from Escherichia phage Mu, GpP from Shewanella oneidensis ( ) and similar proteins found in tailed bacteriophages and bacterial prophages. This domain is located C-terminal to and N-terminal to .

[]

0

[ "PFAM" ]

[ "PF22255" ]

[ "Gp44-like_2nd" ]

[ 2308 ]

1

[]

0

[ "1wru", "3cdd", "3d37", "9ki1" ]

4

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 2252, 34, 8, 14 ]

4

[]

0

true

Domain

Baseplate hub protein gp44/GpP-like, second domain

Gp44/GpP-like_2nd

6

IPR053982

53,982

Baseplate hub protein gp44/GpP-like, C-terminal

Gp44/GpP-like_C

Domain

1,817

false

This domain is found in baseplate hub protein gp44 from Escherichia phage Mu, Mu phage baseplate assembly protein GpP from Shewanella oneidensis ( ) and similar sequences found in tailed bacteriophages and prophages from proteobacteria. It is normally found associated with .

[]

0

[ "PFAM" ]

[ "PF21929" ]

[ "GpP_4th" ]

[ 1817 ]

1

[]

0

[ "1wru", "3cdd", "9ki1" ]

3

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 1787, 11, 6, 13 ]

4

[]

0

true

Domain

Baseplate hub protein gp44/GpP-like, C-terminal

Gp44/GpP-like_C

8

IPR053983

53,983

BDI_1685-like, C-terminal domain

BDI_1685-like_C

Domain

51

false

This domain is found at the C-terminal end of BDI_1685 from Parabacteroides distasonis ( ) and similar bacterial sequences. This domain is usually found associated with .

[]

0

[ "PFAM" ]

[ "PF22256" ]

[ "BDI_1685-like_C" ]

[ 51 ]

1

[]

0

[ "5cd6" ]

1

[]

0

[]

0

null

[ "Bacteria" ]

[ 51 ]

1

[]

0

true

Domain

BDI_1685-like, C-terminal domain

BDI_1685-like_C

7

IPR053984

53,984

GPR128, N-terminal domain

GPR128_N

Domain

491

false

GRP128, also known as Adhesion G-protein coupled receptor G7 (AGRG7), is an orphan receptor of the adhesion family (subclass B2) that belongs to class B GPCRs. Expression of GPR128 was detected in the mouse intestinal mucosa and is thought to be involved in energy balance [ , ]. This entry represents the N-terminal dom...

[]

0

[ "PFAM" ]

[ "PF22257" ]

[ "GPR128_N" ]

[ 491 ]

1

[]

0

[]

0

[ "PUB00058430", "PUB00137741", "PUB00137742" ]

[ "22333914", "24574718", "19797732" ]

[ "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.", "Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency.", "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals." ]

[ 2012, 2014, 2010 ]

3

[]

0

null

[ "Deuterostomia" ]

[ 491 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 1, 2 ]

4

true

Domain

GPR128, N-terminal domain

GPR128_N

2

IPR053985

53,985

GPR128, GAIN subdomain A

GPR128_GAIN_subdom_A

Domain

604

false

GRP128, also known as Adhesion G-protein coupled receptor G7 (AGRG7), is an orphan receptor of the adhesion family (subclass B2) that belongs to class B GPCRs. Expression of GPR128 was detected in the mouse intestinal mucosa and is thought to be involved in energy balance [ , ]. It consists of an N-terminal HormR-like ...

[]

0

[ "PFAM" ]

[ "PF22259" ]

[ "GPR128_GAIN_subdomA" ]

[ 604 ]

1

[]

0

[]

0

[ "PUB00058430", "PUB00137741", "PUB00137742" ]

[ "22333914", "24574718", "19797732" ]

[ "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.", "Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency.", "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals." ]

[ 2012, 2014, 2010 ]

3

[]

0

null

[ "Eukaryota" ]

[ 604 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1, 2 ]

4

true

Domain

GPR128, GAIN subdomain A

GPR128_GAIN_subdom_A

8

IPR053986

53,986

GPR128, GAIN subdomain B

GPR128_GAIN_subdom_B

Domain

650

false

GRP128, also known as Adhesion G-protein coupled receptor G7 (AGRG7), is an orphan receptor of the adhesion family (subclass B2) that belongs to class B GPCRs. Expression of GPR128 was detected in the mouse intestinal mucosa and is thought to be involved in energy balance [ , ]. It consists of an N-terminal HormR-like ...

[]

0

[ "PFAM" ]

[ "PF22261" ]

[ "GPR128_GAIN_subdom_B" ]

[ 650 ]

1

[]

0

[]

0

[ "PUB00058430", "PUB00137741", "PUB00137742" ]

[ "22333914", "24574718", "19797732" ]

[ "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.", "Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency.", "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals." ]

[ 2012, 2014, 2010 ]

3

[ "IPR057244" ]

[]

1

0

1

[ "Eumetazoa", "Pontibacter" ]

[ 648, 2 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 5, 1, 2 ]

4

true

Domain

GPR128, GAIN subdomain B

GPR128_GAIN_subdom_B

1

IPR053987

53,987

Transcriptional regulator MlrA-like, C-terminal domain

MlrA-like_C

Domain

2,581

false

The HTH transcription regulator MlrA belongs to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by re configuring the spacer between the -35 and -10 promoter elements. MlrA it is also known as YehV, and has been shown to control cell-cell aggregation by co-regula...

[]

0

[ "PFAM" ]

[ "PF22267" ]

[ "MlrA_C" ]

[ 2581 ]

1

[]

0

[]

0

[ "PUB00115538", "PUB00151466", "PUB00154392" ]

[ "11489123", "23708798", "22783906" ]

[ "MlrA, a novel regulator of curli (AgF) and extracellular matrix synthesis by Escherichia coli and Salmonella enterica serovar Typhimurium.", "The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control.", "Molecular function and potential evolution of the bi...

[ 2001, 2013, 2012 ]

3

[]

0

null

[ "Opisthokonta", "Pseudomonadati", "metagenomes" ]

[ 5, 2574, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Transcriptional regulator MlrA-like, C-terminal domain

MlrA-like_C

2

IPR053988

53,988

Transcriptional regulator MlrA-like, helical domain

MlrA-like_helical

Domain

2,524

false

The HTH transcription regulator MlrA belongs to the MerR superfamily of transcription regulators that promote expression of several stress regulon genes by re configuring the spacer between the -35 and -10 promoter elements. MlrA it is also known as YehV, and has been shown to control cell-cell aggregation by co-regula...

[]

0

[ "PFAM" ]

[ "PF22270" ]

[ "MlrA_helical" ]

[ 2524 ]

1

[]

0

[]

0

[ "PUB00115538", "PUB00151466", "PUB00154392" ]

[ "11489123", "23708798", "22783906" ]

[ "MlrA, a novel regulator of curli (AgF) and extracellular matrix synthesis by Escherichia coli and Salmonella enterica serovar Typhimurium.", "The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control.", "Molecular function and potential evolution of the bi...

[ 2001, 2013, 2012 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 2519, 5 ]

2

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Transcriptional regulator MlrA-like, helical domain

MlrA-like_helical

7

IPR053989

53,989

Teichoic acid transporter subunit TagH, SH3-like domain

TagH_SH3-like

Domain

166

false

This domain is found in TagH from Staphylococcus epidermidis ( ), the ATPase subunit of the two-component transporter TagGH, which is involved in the synthesis of bacterial polysaccharides-wall teichoic acids. This entry represents the middle SH3-like subdomain that consists of a twisted antiparallel β-sheet and two β-...

[]

0

[ "PFAM" ]

[ "PF22269" ]

[ "TagH_SH3-like" ]

[ 166 ]

1

[]

0

[ "5bnd" ]

1

[ "PUB00154255" ]

[ "27213893" ]

[ "SH3-like motif-containing C-terminal domain of staphylococcal teichoic acid transporter suggests possible function." ]

[ 2016 ]

1

[]

0

null

[ "Staphylococcaceae", "human gut metagenome" ]

[ 165, 1 ]

2

[]

0

true

Domain

Teichoic acid transporter subunit TagH, SH3-like domain

TagH_SH3-like

4

IPR053990

53,990

Teichoic acid transporter subunit TagH, C-terminal domain

TagH_C

Domain

188

false

TagH from Staphylococcus epidermidis ( ) is the ATPase subunit of the two-component transporter TagGH involved in the synthesis of bacterial polysaccharides-wall teichoic acids. This entry represents the C-terminal of TagH that adopts an α/β structure consisting of a central antiparallel mixed β-sheet packed on one sid...

[]

0

[ "PFAM" ]

[ "PF22096" ]

[ "TagH_C" ]

[ 188 ]

1

[]

0

[ "5bnd" ]

1

[ "PUB00154255" ]

[ "27213893" ]

[ "SH3-like motif-containing C-terminal domain of staphylococcal teichoic acid transporter suggests possible function." ]

[ 2016 ]

1

[]

0

null

[ "Bacillales", "human gut metagenome" ]

[ 187, 1 ]

2

[]

0

true

Domain

Teichoic acid transporter subunit TagH, C-terminal domain

TagH_C

7

IPR053992

53,992

ATR1, N-terminal domain

ATR1_N

Domain

7

false

Host-adapted plant pathogens secrete numerous effectors into the host extracellular spaces or inside cells. The A. thaliana TNL receptor RPP1 confers strain-specific immunity through recognition of H.arabidopsidis effector ATR1. ATR1 consists of two α-helical domains that are involved in interactions with the receptor....

[]

0

[ "PFAM" ]

[ "PF22223" ]

[ "ATR1_N" ]

[ 7 ]

1

[]

0

[ "3rmr", "7crb", "7crc" ]

3

[ "PUB00098642" ]

[ "33273071" ]

[ "Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme." ]

[ 2020 ]

1

[]

0

null

[ "Peronosporaceae" ]

[ 7 ]

1

[]

0

true

Domain

ATR1, N-terminal domain

ATR1_N

9

IPR053993

53,993

Cas12a, PI domain

Cas12a_PI

Domain

127

false

This entry represents the PI (PAM-interacting) domain found in Cpf1, also known as CRISPR-associated endonuclease Cas12a. The CRISPR-Cpf1 system is a class 2 CRISPR-Cas system that mediates robust DNA interference. Cpf1 differ from Cas9 in many aspects, including the guide RNAs and substrate specificity. The Cpf1-crRNA...

[]

0

[ "PFAM" ]

[ "PF22222" ]

[ "Cpf1_PI-like" ]

[ 127 ]

1

[]

0

[ "5id6", "5mga", "5nfv", "5ng6", "5xus", "5xut", "5xuu", "5xuz", "6gtc", "6gtd", "6gte", "6gtf", "6gtg", "6i1k", "6i1l", "6iv6", "6kl9", "6klb", "6nm9", "6nma", "6nmc", "6nmd", "6nme", "6omv", "6p7m", "6p7n", "8h9d", "8i54", "8kgf", "8qwd", "8qwe", "8qwf"...

44

[ "PUB00087324", "PUB00087325", "PUB00153855", "PUB00153885", "PUB00153886" ]

[ "28431230", "28562584", "27096363", "28781234", "30503205" ]

[ "Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.", "Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage.", "The crystal structure of Cpf1 in complex with CRISPR RNA.", "Structural Basis for the Canonical and Non-canonical PAM Recognition by ...

[ 2017, 2017, 2016, 2017, 2018 ]

5

[]

0

null

[ "Bacteria", "Methanomassiliicoccales", "Potamilus streckersoni", "bioreactor metagenome" ]

[ 122, 3, 1, 1 ]

4

[]

0

true

Domain

Cas12a, PI domain

Cas12a_PI

2

IPR053994

53,994

NigD-like, OB domain

NigD-like_OB

Domain

93

false

This entry represents an OB fold domain found in NigD and related proteins from bacteria.

[]

0

[ "PFAM" ]

[ "PF22221" ]

[ "NigD_N-like" ]

[ 93 ]

1

[]

0

[ "5bmt" ]

1

[]

0

[]

0

null

[ "Bacteroidales", "bioreactor metagenome" ]

[ 92, 1 ]

2

[]

0

true

Domain

NigD-like, OB domain

NigD-like_OB

2

IPR053995

53,995

Quiescin sulphydryl oxidase, pseudo-Erv domain

QSOX_pErv

Domain

51

false

Quiescin sulphydryl oxidase (QSOX) family of enzymes is the only known example of conserved concatenation of disulphide-generating and disulphide-transferring modules within a single polypeptide. Formation and transfer of disulphide bonds in QSOX are mediated by redox-active cysteine pairs in a canonical Cys-X-X-Cys pa...

[]

0

[ "PFAM" ]

[ "PF22220" ]

[ "QSOX_pErv" ]

[ 51 ]

1

[]

0

[ "3qcp", "3qd9" ]

2

[ "PUB00061153" ]

[ "22801504" ]

[ "The dynamic disulphide relay of quiescin sulphydryl oxidase." ]

[ 2012 ]

1

[]

0

null

[ "Metakinetoplastina" ]

[ 51 ]

1

[]

0

true

Domain

Quiescin sulphydryl oxidase, pseudo-Erv domain

QSOX_pErv

1

IPR053996

53,996

DUF3829-like, C-terminal domain

DUF3829-like_C

Domain

137

false

This domain is found at the C-terminal end of uncharacterised DUF3829-like proteins. It is often found associated to . Its function is unknown. It shows four α-helices.

[]

0

[ "PFAM" ]

[ "PF22219" ]

[ "DUF3829_2nd" ]

[ 137 ]

1

[]

0

[ "3iee", "3rh3" ]

2

[]

0

[]

0

null

[ "Bacteroidales" ]

[ 137 ]

1

[]

0

true

Domain

DUF3829-like, C-terminal domain

DUF3829-like_C

7

IPR053997

53,997

SAS-6, C-terminal coiled coil

SAS-6_C_CC

Domain

102

false

This domain is found at the C-terminal end of Spindle assembly abnormal protein 6 (Sas-6). Sas-6 is a central scaffolding component of the centrioles ensuring their nine-fold symmetry. Sas-6 forms a dimer through this domain to then further homo-oligomerise to form a ring structure from which the CC domains emanate as ...

[]

0

[ "PFAM", "PFAM" ]

[ "PF22216", "PF22218" ]

[ "Sas-6_C_CC", "SAS-6_C_CC_2" ]

[ 61, 41 ]

2

[]

0

[ "4ckn", "4ckp", "5al7" ]

3

[ "PUB00154221", "PUB00154222" ]

[ "26002084", "24596152" ]

[ "The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.", "Structure of the SAS-6 cartwheel hub from Leishmania major." ]

[ 2015, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 97 ]

2

[ "Drosophila melanogaster" ]

[ 1 ]

1

true

Domain

SAS-6, C-terminal coiled coil

SAS-6_C_CC

3

IPR053998

53,998

Acyl-CoA dehydrogenase 11-like C-terminal domain

ACDH-11_C

Domain

1,215

false

Acyl-CoA dehydrogenase 11 (ACDH-11) sequesters C11/C12-chain fatty acids and prevents these fatty acids from activating nuclear hormone receptors and driving fat-7 expression. This enzyme consists of four domains, of which the C-terminal folds into a four-helical up-and-down bundle [ ].

[]

0

[ "PFAM" ]

[ "PF22217" ]

[ "ACDH-11_C" ]

[ 1215 ]

1

[]

0

[ "4y9j", "4y9l" ]

2

[ "PUB00082831" ]

[ "25981666" ]

[ "Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "ecological metagenomes" ]

[ 173, 1005, 35, 2 ]

4

[ "Caenorhabditis elegans", "Danio rerio" ]

[ 1, 3 ]

2

true

Domain

Acyl-CoA dehydrogenase 11-like C-terminal domain

ACDH-11_C

7

IPR054000

54,000

Mixed lineage kinase domain-like, N-terminal domain

MLKL_N

Domain

2,791

false

Mixed-lineage kinase domain-like (MLKL) is crucial for necroptosis, permeabilising membranes via its N-terminal domain upon phosphorylation of its kinase-like domain by RIP3. The MLKL N-terminal domain forms a four-helical up-and-down bundle that is sufficient to induce liposome leakage and a fifth C-terminal helix tha...

[]

0

[ "PFAM" ]

[ "PF22215" ]

[ "MLKL_N" ]

[ 2791 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3295583", "R-HSA-5213460", "R-HSA-5675482", "R-HSA-9686347", "R-MMU-3295583", "R-MMU-5213460", "R-MMU-5675482" ]

[ "REACTOME:R-HSA-3295583", "REACTOME:R-HSA-5213460", "REACTOME:R-HSA-5675482", "REACTOME:R-HSA-9686347", "REACTOME:R-MMU-3295583", "REACTOME:R-MMU-5213460", "REACTOME:R-MMU-5675482" ]

7

[ "2msv", "4btf", "6d74", "6lk5", "6ux8", "6zle", "6zpr", "6zvo", "6zz1", "7nm2", "7nm4", "7nm5" ]

12

[ "PUB00146334", "PUB00146335", "PUB00154068", "PUB00154069", "PUB00154070" ]

[ "25220470", "24012422", "31031142", "34158471", "32234780" ]

[ "A plug release mechanism for membrane permeation by MLKL.", "The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.", "Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.", "The MLKL kinase-like domain dimerization is an indispensable step of mammal...

[ 2014, 2013, 2019, 2021, 2020 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2791 ]

1

[ "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 2, 5, 3, 3 ]

5

true

Domain

Mixed lineage kinase domain-like, N-terminal domain

MLKL_N

2

IPR054001

54,001

Degenerin mec-4/10, cytosolic domain

Mec-4/10_cyt

Domain

132

false

This entry represents the cytosolic domain found in Degenerin mec-4 and mec-10, the pore-forming subunits of the sensory mechanotransduction complex that mediates touch sensation [ ].

[]

0

[ "PFAM" ]

[ "PF22214" ]

[ "Mec-4_10_cyt" ]

[ 132 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-CEL-2672351", "R-CEL-9730628" ]

[ "REACTOME:R-CEL-2672351", "REACTOME:R-CEL-9730628" ]

2

[ "2k2b", "5ttt" ]

2

[ "PUB00154059" ]

[ "17261841" ]

[ "Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade." ]

[ 2007 ]

1

[]

0

null

[ "Chromadorea" ]

[ 132 ]

1

[ "Caenorhabditis elegans" ]

[ 2 ]

1

true

Domain

Degenerin mec-4/10, cytosolic domain

Mec-4/10_cyt

4

IPR054002

54,002

RNA-directed RNA polymerase, C-terminal

RdRP_C

Domain

62

false

This domain is found at the C-terminal of RNA-directed RNA polymerase (RdRP). This protein adopts a closed cage-like structure consisting of a central polymerase domain sandwiched between N-terminal and C-terminal bracelet domains. This domain adopts a predominantly α-helical configuration [ , , , , ].

[]

0

[ "PFAM" ]

[ "PF22213" ]

[ "CPV_RdRP_C" ]

[ 62 ]

1

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[ "3ja4", "3ja5", "3jb6", "3jb7", "5h0r", "6k32", "6ty8", "6ty9", "6tz0", "6tz1", "6tz2" ]

11

[ "PUB00152701", "PUB00153887", "PUB00153888", "PUB00153889", "PUB00153890" ]

[ "31629769", "26383954", "26503045", "27914893", "31695188" ]

[ "Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis.", "Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus.", "In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus.", "Near-Atomic R...

[ 2020, 2015, 2015, 2017, 2019 ]

5

[]

0

null

[ "Riboviria" ]

[ 62 ]

1

[]

0

true

Domain

RNA-directed RNA polymerase, C-terminal

RdRP_C

3

IPR054004

54,004

Type six secretion immunity 3 domain

Tsi3

Domain

42

false

This entry represents the Tsi3 domain. Tsi3 immunity protein prevents early activation of toxin Tse3. Three loops of Tsi3 deeply insert into the groove of Tse3, fully blocking its active site. This interaction serves as the structural basis for Tse3 inactivation [ , , ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF038331", "PF22211" ]

[ "Tsi3_fam", "Tsi3" ]

[ 31, 40 ]

2

[]

0

[ "3wa5", "4luq", "4m5f", "4n7s", "4n80", "4n88", "8ik0", "8ik3" ]

8

[ "PUB00105729", "PUB00105730", "PUB00154253" ]

[ "24100309", "24724564", "24025333" ]

[ "Complex structure of type VI peptidoglycan muramidase effector and a cognate immunity protein.", "Structural insights into the T6SS effector protein Tse3 and the Tse3-Tsi3 complex from Pseudomonas aeruginosa reveal a calcium-dependent membrane-binding mechanism.", "Structural Insights on the bacteriolytic and ...

[ 2013, 2014, 2013 ]

3

[]

0

null

[ "Bacteria" ]

[ 42 ]

1

[]

0

true

Domain

Type six secretion immunity 3 domain

Tsi3

9

IPR054005

54,005

VP17, central beta-barrel

VP17_central_barrel

Domain

21

false

This entry represents the central β-barrel of VP17, the large major capsid protein of of bacteriophage P23-77 [ ].

[]

0

[ "PFAM" ]

[ "PF22210" ]

[ "VP17_central_barrel" ]

[ 21 ]

1

[]

0

[ "3zmn", "3zn6" ]

2

[ "PUB00067131" ]

[ "23623731" ]

[ "Bacteriophage p23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage." ]

[ 2013 ]

1

[]

0

null

[ "Deinococci", "Hukuchivirus" ]

[ 19, 2 ]

2

[]

0

true

Domain

VP17, central beta-barrel

VP17_central_barrel

2

IPR054006

54,006

RNA-directed RNA polymerase, N-terminal

RdRP_N

Domain

129

false

This domain is found at the N terminus of RNA-directed RNA polymerase (RdRP) found in reoviruses. This protein adopts a closed cage-like structure consisting of a central polymerase domain sandwiched between the N-terminal and the C-terminal bracelet domains. This domain adopts a predominantly α-helical configuration [...

[]

0

[ "PFAM" ]

[ "PF22209" ]

[ "CPV_RdRP_N" ]

[ 129 ]

1

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[ "3ja4", "3ja5", "3jb6", "3jb7", "5h0r", "6k32", "6ty8", "6ty9", "6tz0", "6tz1", "6tz2" ]

11

[ "PUB00152701", "PUB00153887", "PUB00153888", "PUB00153889", "PUB00153890" ]

[ "31629769", "26383954", "26503045", "27914893", "31695188" ]

[ "Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis.", "Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus.", "In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus.", "Near-Atomic R...

[ 2020, 2015, 2015, 2017, 2019 ]

5

[]

0

null

[ "Apolygus lucorum", "Viruses" ]

[ 2, 127 ]

2

[]

0

true

Domain

RNA-directed RNA polymerase, N-terminal

RdRP_N

8

IPR054007

54,007

MCM3 winged helix domain

WHD_MCM3

Domain

50

false

This entry represents the C-terminal winged helix domain found in yeast DNA replication licensing factor MCM3. This protein acts as a component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells...

[]

0

[ "PFAM" ]

[ "PF22207" ]

[ "WHD_MCM3" ]

[ 50 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-SCE-176187", "R-SCE-68867", "R-SCE-68962", "R-SCE-69052" ]

[ "REACTOME:R-SCE-176187", "REACTOME:R-SCE-68867", "REACTOME:R-SCE-68962", "REACTOME:R-SCE-69052" ]

4

[ "3ja8", "3jc5", "3jc6", "3jc7", "5bk4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6rqc", "6skl", "6sko", "6wgc", "6wgf", "6wgg", "6wgi", "7p30", "7p5z", "7pmk", "7pmn", "7pt6", "7pt7", "7qhs", "7v3u", "7v3v", "7w8g"...

55

[ "PUB00063043", "PUB00138519", "PUB00152060", "PUB00154054" ]

[ "19896182", "26222030", "26854665", "28191894" ]

[ "Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.", "Structure of the eukaryotic MCM complex at 3.8 A.", "Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.", "Open-ringed structure of the Cdt1-Mcm2-7 complex as a p...

[ 2009, 2015, 2016, 2017 ]

4

[]

0

null

[ "Saccharomycetaceae" ]

[ 50 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

MCM3 winged helix domain

WHD_MCM3

5

IPR054008

54,008

Csm6 6H domain

Csm6_6H

Domain

185

false

This entry represents the six-helix domain (6H) of CRISPR system endoribonuclease Csm6 from Thermus termophilus and related sequences [ ]. Csm6 is a ssRNA-specific endoribonuclease that provides an auxiliary RNA-targeting interference mechanism in type III-A CRISPR-Cas systems, working together with the RNA- and DNA-ta...

[]

0

[ "PFAM" ]

[ "PF22205" ]

[ "Csm6_6H" ]

[ 185 ]

1

[]

0

[ "5fsh", "8jbb", "8jbc", "8jh1" ]

4

[ "PUB00106708", "PUB00153094", "PUB00153854" ]

[ "31326273", "33461211", "26763118" ]

[ "CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity.", "The Card1 nuclease provides defence during type III CRISPR immunity.", "Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated pro...

[ 2019, 2021, 2016 ]

3

[]

0

null

[ "Archaea", "Bacteria", "marine sediment metagenome" ]

[ 32, 151, 2 ]

3

[]

0

true

Domain

Csm6 6H domain

Csm6_6H

7

IPR054009

54,009

CRISPR-associated endonuclease C2c1, wedge domain, second region

C2c1_WED-II

Domain

16

false

This entry represents the second region of the wedge domain (WED-II) of CRISPR-associated endonuclease C2c1 (also known as Cas12b). It adopts an oligonucleotide-binding (OB) fold with eight β-stranded distorted β-sheets flanked by two α-helices and one β-hairpin [ , ]. C2c1 is a class 2 type V-B effector protein that w...

[]

0

[ "PFAM" ]

[ "PF22204" ]

[ "C2c1_WED-II" ]

[ 16 ]

1

[]

0

[ "5u30", "5u31", "5u33", "5u34", "5wqe", "5wti" ]

6

[ "PUB00153840", "PUB00153841" ]

[ "27984729", "27989439" ]

[ "PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.", "C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism." ]

[ 2016, 2017 ]

2

[]

0

null

[ "Bacteria" ]

[ 16 ]

1

[]

0

true

Domain

CRISPR-associated endonuclease C2c1, wedge domain, second region

C2c1_WED-II

9

IPR054010

54,010

CRISPR-associated endonuclease C2c1, Nuc-II domain

C2c1_Nuc-II

Domain

18

false

This entry represents the C-terminal second Nuc (Nuc-II) domain of C2c1 CRISPR-Cas endonuclease (also known as Cas12b). This domain folds into an open five-stranded β-barrel and an α-helix. Nuc-II is essential for cleavage activity. C2c1 is a class 2 type V-B effector protein that was shown to be active for target DNA ...

[]

0

[ "PFAM" ]

[ "PF22077" ]

[ "C2c1_Nuc-II" ]

[ 18 ]

1

[]

0

[ "5u30", "5u31", "5u33", "5u34", "5wqe", "5wti" ]

6

[ "PUB00153840", "PUB00153841" ]

[ "27984729", "27989439" ]

[ "PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.", "C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism." ]

[ 2016, 2017 ]

2

[]

0

null

[ "Bacteria" ]

[ 18 ]

1

[]

0

true

Domain

CRISPR-associated endonuclease C2c1, Nuc-II domain

C2c1_Nuc-II

4

IPR054011

54,011

C2c1 CRISPR-Cas endonuclease, RuvC-like domain

C2c1_RuvC-like

Domain

22

false

This entry represents the RuvC-like domain of C2c1 CRISPR-Cas endonuclease (also known as Cas12b). C2c1 is a class 2 type V-B effector protein that was shown to be active for target DNA cleavage in vivo and in vitro. In contrast to Cpf1, this enzyme cleavage activity requires both crRNA and tracrRNA. The structure of C...

[]

0

[ "PFAM" ]

[ "PF22126" ]

[ "C2c1_RuvC-like" ]

[ 22 ]

1

[]

0

[ "5u30", "5u31", "5u33", "5u34", "5wqe", "5wti", "9kln", "9klo", "9klp", "9klq" ]

10

[ "PUB00153840", "PUB00153841", "PUB00153842" ]

[ "27984729", "27989439", "28374750" ]

[ "PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.", "C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism.", "Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA." ]

[ 2016, 2017, 2017 ]

3

[]

0

null

[ "Bacteria" ]

[ 22 ]

1

[]

0

true

Domain

C2c1 CRISPR-Cas endonuclease, RuvC-like domain

C2c1_RuvC-like

9

IPR054012

54,012

CRISPR-associated endonuclease C2c1, second helical domain

C2c1_helical_2nd

Domain

17

false

This entry represents the second helical domain (REC2) from CRISPR-associated endonuclease C2c1 (also known as Cas12b). This domain, together with the first helical domain (helical-I or REC1) ( ) forms the α-recognition (REC) lobe, which recognises a 20bp guide:target heteroduplex in RNAs [ , ]. C2c1 is a class 2 type ...

[]

0

[ "PFAM" ]

[ "PF22172" ]

[ "C2c1_helical" ]

[ 17 ]

1

[]

0

[ "5u30", "5u31", "5u33", "5u34", "5wqe", "5wti" ]

6

[ "PUB00153840", "PUB00153841", "PUB00153842" ]

[ "27984729", "27989439", "28374750" ]

[ "PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.", "C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism.", "Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA." ]

[ 2016, 2017, 2017 ]

3

[]

0

null

[ "Bacteria" ]

[ 17 ]

1

[]

0

true

Domain

CRISPR-associated endonuclease C2c1, second helical domain

C2c1_helical_2nd

8

IPR054013

54,013

CRISPR-associated endonuclease C2c1, first helical domain

C2c1_helical_1st

Domain

20

false

This entry represents the first helical domain (REC1) of CRISPR-associated endonuclease C2c1 (also known as Cas12b). This domain, together with the second helical domain ( ) forms the α-recognition (REC) lobe, which recognises a 20bp guide:target heteroduplex in RNAs [ , ]. C2c1 is a class 2 type V-B effector protein t...

[]

0

[ "PFAM" ]

[ "PF22202" ]

[ "C2c1_helical_1st" ]

[ 20 ]

1

[]

0

[ "5u30", "5u31", "5u33", "5u34", "5wqe", "5wti" ]

6

[ "PUB00153840", "PUB00153841", "PUB00153842" ]

[ "27984729", "27989439", "28374750" ]

[ "PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.", "C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism.", "Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA." ]

[ 2016, 2017, 2017 ]

3

[]

0

null

[ "Bacteria" ]

[ 20 ]

1

[]

0

true

Domain

CRISPR-associated endonuclease C2c1, first helical domain

C2c1_helical_1st

7

IPR054014

54,014

Surface cell antigen Sca2 helical repeat

Sca2

Repeat

53

false

Sca2 (surface cell antigen 2) is the only bacterial protein known to promote both actin filament nucleation and profilin-dependent elongation, mimicking eukaryotic formins to assemble actin comet tails for Rickettsia motility. Sca2's functional mimicry of formins is achieved through a unique mechanism. Unlike formins, ...

[]

0

[ "PFAM" ]

[ "PF22203" ]

[ "Sca2" ]

[ 53 ]

1

[]

0

[ "4j7o" ]

1

[ "PUB00154223" ]

[ "23818602" ]

[ "Rickettsia Sca2 has evolved formin-like activity through a different molecular mechanism." ]

[ 2013 ]

1

[]

0

null

[ "Rickettsia" ]

[ 53 ]

1

[]

0

true

Repeat

Surface cell antigen Sca2 helical repeat

Sca2

6

IPR054015

54,015

ExsA-like, N-terminal regulatory domain

ExsA-like_N

Domain

3,809

false

This entry represents the ExsA regulatory domain which mediates the ExsD binding. The structure of this domain closely resembles those of the regulatory domains of AraC and ToxT, having typical cupin-like fold [ ]. ExsA is an AraC-type transcriptional activator protein that is regulated through protein-protein interact...

[]

0

[ "PFAM" ]

[ "PF22200" ]

[ "ExsA_N" ]

[ 3809 ]

1

[]

0

[ "4zua" ]

1

[ "PUB00153932", "PUB00154393", "PUB00154394" ]

[ "26317977", "1624422", "2644192" ]

[ "Structural Analysis of the Regulatory Domain of ExsA, a Key Transcriptional Regulator of the Type Three Secretion System in Pseudomonas aeruginosa.", "Temperature sensing in Yersinia pestis: regulation of yopE transcription by lcrF.", "Homology between virF, the transcriptional activator of the Yersinia virule...

[ 2015, 1992, 1989 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3789, 5, 15 ]

3

[]

0

true

Domain

ExsA-like, N-terminal regulatory domain

ExsA-like_N

3

IPR054016

54,016

FKBP26, IF domain

FKBP26_IF

Domain

862

false

This domain is centrally located in Long-type peptidyl-prolyl cis-trans isomerase from Methanocaldococcus jannaschii (FKBP26) and similar archaeal sequences. FKBP26 catalyses the cis-trans isomerisation of peptidyl prolyl bonds and exhibits chaperone-like activity. The latter activity requires a 50-residue insertion (I...

[]

0

[ "PFAM" ]

[ "PF22199" ]

[ "FKBP26_IF" ]

[ 862 ]

1

[]

0

[ "3pr9", "3pra", "3prb", "3prd" ]

4

[ "PUB00026168", "PUB00065543" ]

[ "12729748", "21262232" ]

[ "Three-dimensional solution structure of an archaeal FKBP with a dual function of peptidyl prolyl cis-trans isomerase and chaperone-like activities.", "Structural analysis of protein folding by the long-chain archaeal chaperone FKBP26." ]

[ 2003, 2011 ]

2

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 832, 5, 25 ]

3

[]

0

true

Domain

FKBP26, IF domain

FKBP26_IF

7

IPR054017

54,017

Glucokinase regulatory protein, second SIS domain

GKRP_SIS_2

Domain

686

false

Glucokinase regulatory protein (GKRP) binds glucokinase (GK) mainly through hydrophobic interactions, functioning as an allosteric switch in blood glucose control by the liver [ ]. GKRP is trilobal in shape, consisting of two topologically identical sugar isomerase (SIS) domains capped by an α-helical lid domain ( ). T...

[]

0

[ "PFAM" ]

[ "PF22198" ]

[ "GKRP_SIS_2" ]

[ 686 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-170822", "R-HSA-5619107", "R-MMU-170822", "R-RNO-170822" ]

[ "REACTOME:R-HSA-170822", "REACTOME:R-HSA-5619107", "REACTOME:R-MMU-170822", "REACTOME:R-RNO-170822" ]

4

[ "3w0l", "4bb9", "4bba", "4lc9", "4ly9", "4mqu", "4mro", "4msu", "4ohk", "4ohm", "4oho", "4ohp", "4olh", "4op1", "4op2", "4op3", "4px2", "4px3", "4px5", "4pxs" ]

20

[ "PUB00067028", "PUB00069412", "PUB00151607", "PUB00152605" ]

[ "23621087", "23733961", "24226772", "23957911" ]

[ "Crystal Structure of Glucokinase Regulatory Protein.", "Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase.", "Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.", "Structural basis for regulation of human glucokinase by gluc...

[ 2013, 2013, 2013, 2013 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 12, 672, 2 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 1, 4 ]

4

true

Domain

Glucokinase regulatory protein, second SIS domain

GKRP_SIS_2

5

IPR054018

54,018

HdrB-like C-terminal domain

HdrB-like_C

Domain

279

false

This entry represents a domain found at the C-terminal of poorly characterised bacterial proteins similar to HdrB from Helicobacter sp.

[]

0

[ "PFAM" ]

[ "PF22196" ]

[ "HdrB-like_C" ]

[ 279 ]

1

[]

0

[ "3kwl" ]

1

[]

0

[]

0

null

[ "Campylobacterales" ]

[ 279 ]

1

[]

0

true

Domain

HdrB-like C-terminal domain

HdrB-like_C

8

IPR054019

54,019

Properdin, thrombospondin type 1 C-terminal

CFP_TSR_C

Repeat

583

false

This represents the C-terminal thrombospondin type I repeat (TSR_C) found in human Properdin (CFP) and similar proteins from vertebrates. Properdin is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is a positive regulator of...

[]

0

[ "PFAM" ]

[ "PF22195" ]

[ "TSP1_CFP_C" ]

[ 583 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-173736", "R-HSA-174577", "R-HSA-5083635", "R-HSA-5173214", "R-HSA-6798695", "R-HSA-977606", "R-MMU-173736", "R-MMU-174577", "R-MMU-5173214", "R-MMU-6798695", "R-MMU-977606" ]

[ "REACTOME:R-HSA-173736", "REACTOME:R-HSA-174577", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-977606", "REACTOME:R-MMU-173736", "REACTOME:R-MMU-174577", "REACTOME:R-MMU-5173214", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-977606" ]

11

[ "1w0r", "1w0s", "6rur", "6rus", "6ruv", "6rv6", "6s08", "6s0a", "6s0b", "6sej", "7b26", "7noz", "8q6r" ]

13

[ "PUB00027123", "PUB00038006", "PUB00138414", "PUB00138415", "PUB00153864", "PUB00153865", "PUB00153866", "PUB00153867", "PUB00153868" ]

[ "12391027", "15491616", "28366782", "28069958", "21821127", "31507604", "31552043", "35031611", "36173177" ]

[ "Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication.", "The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modelling.", "Identification and characterizati...

[ 2002, 2004, 2017, 2017, 2011, 2019, 2019, 2022, 2022 ]

9

[]

0

null

[ "Eumetazoa" ]

[ 583 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 2, 3 ]

4

true

Repeat

Properdin, thrombospondin type 1 C-terminal

CFP_TSR_C

7

IPR054020

54,020

F93, winged-helix domain

WHD_F93

Domain

22

false

This entry represents a WH-like domain ( ) found in a putative transcription factor called F-93 from Sulfolobus spindle-shaped viruses (SSVs) ( ) [ ] and related proteins. Members of this family appear to be related to MarR ( ) and PadR ( ) families of prokaryotic transcription factors.

[]

0

[ "PFAM" ]

[ "PF22194" ]

[ "WHD_F93" ]

[ 22 ]

1

[]

0

[ "1tbx" ]

1

[ "PUB00031401" ]

[ "15479795" ]

[ "Crystal structure of F-93 from Sulfolobus spindle-shaped virus 1, a winged-helix DNA binding protein." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Neisseria subflava", "Viruses incertae sedis" ]

[ 16, 1, 5 ]

3

[]

0

true

Domain

F93, winged-helix domain

WHD_F93

6

IPR054021

54,021

MvcA insertion domain

MvcA_ins

Domain

22

false

This entry represents the insertion domain of MvcA, the MavC paralogue A of bacterial effector MavC from Legionella pneumophila. MvcA catalyses the reverse reaction of MavC, removing Ub from Ube2N through hydrolysis which regulates MavC activity. MvcA is similar at sequence and structural levels to MavC, and it exhibit...

[]

0

[ "PFAM" ]

[ "PF22193" ]

[ "MvcA_ins" ]

[ 22 ]

1

[]

0

[ "5suj", "5tsc", "5ym9", "6jky", "6k11", "6k3b", "6kfp", "6kg6", "6kl4", "6lp2", "6lw4", "6p5b", "6p5h", "6ulh", "6ump", "6ums", "7bxf", "7bxg", "7bxh" ]

19

[ "PUB00154089", "PUB00154090", "PUB00154091", "PUB00154092", "PUB00154093" ]

[ "29642013", "31825121", "32286321", "32596129", "32398758" ]

[ "Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila.", "Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination.", "Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector...

[ 2018, 2020, 2020, 2020, 2020 ]

5

[]

0

null

[ "Legionella pneumophila" ]

[ 22 ]

1

[]

0

true

Domain

MvcA insertion domain

MvcA_ins

9

IPR054022

54,022

RickCE N-terminal domain

RickCE_N

Domain

44

false

This is a presumed domain found at the N-terminal end of rickCE ubiquitin-like proteases, such as , which may have a Rossmann-like fold similar to that in glycosyltransferases.

[]

0

[ "PFAM" ]

[ "PF22189" ]

[ "RickCE_N" ]

[ 44 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rickettsieae" ]

[ 44 ]

1

[]

0

true

Domain

RickCE N-terminal domain

RickCE_N

8