LiteFold/InterPro · Datasets at Hugging Face

IPR054474

54,474

Diacylglycerol kinase eta/delta/kappa, helical domain

DGKD_4H

Domain

4,773

false

This domain is found in diacylglycerol kinase isoenzymes eta (DGKH), delta (DGKD), and kappa (DGKK) [ , , , ]. These enzymes play important roles in lipid signaling by converting diacylglycerol to phosphatidic acid. DGKD is a multidomain protein composed of seven globular domains. The domain represented by this entry l...

[]

0

[ "PFAM" ]

[ "PF22944" ]

[ "DGKD_4H" ]

[ 4773 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1.107", "PWY-7039", "PWY-7817", "R-DME-114508", "R-HSA-114508", "R-MMU-114508" ]

[ "EC:2.7.1.107", "METACYC:PWY-7039", "METACYC:PWY-7817", "REACTOME:R-DME-114508", "REACTOME:R-HSA-114508", "REACTOME:R-MMU-114508" ]

6

[]

0

[ "PUB00103262", "PUB00127493", "PUB00144950", "PUB00154452" ]

[ "12810723", "12200442", "16210324", "23949095" ]

[ "Identification and characterization of two splice variants of human diacylglycerol kinase eta.", "Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions.", "Identification and characterization of a novel human...

[ 2003, 2002, 2005, 2013 ]

4

[]

0

null

[ "Metazoa" ]

[ 4773 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 39, 6, 7, 12, 15 ]

5

true

Domain

Diacylglycerol kinase eta/delta/kappa, helical domain

DGKD_4H

4

IPR054475

54,475

DNA polymerase-epsilon, zinc finger domain

Znf-DPOE

Domain

4,334

false

This zinc finger domain is found in the epsilon subunit of eukaryotic DNA polymerase which is involved in DNA synthesis during DNA repair [ , ]. This domain is also found in DNA polymerase II large subunit DP2 from archaea, which is the large subunit of a two-subunit archaebacterial replicative DNA polymerase.

[]

0

[ "PFAM" ]

[ "PF22912" ]

[ "zf-DPOE" ]

[ 4334 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.7", "R-DDI-110314", "R-DDI-5651801", "R-DDI-5656169", "R-DDI-5696397", "R-DDI-6782135", "R-DDI-6782210", "R-DDI-68952", "R-DDI-68962", "R-DME-110314", "R-DME-5651801", "R-DME-5656169", "R-DME-5696400", "R-DME-6782135", "R-DME-68952", "R-DME-68962", "R-HSA-110314", "R-HSA-565...

[ "EC:2.7.7.7", "REACTOME:R-DDI-110314", "REACTOME:R-DDI-5651801", "REACTOME:R-DDI-5656169", "REACTOME:R-DDI-5696397", "REACTOME:R-DDI-6782135", "REACTOME:R-DDI-6782210", "REACTOME:R-DDI-68952", "REACTOME:R-DDI-68962", "REACTOME:R-DME-110314", "REACTOME:R-DME-5651801", "REACTOME:R-DME-5656169", ...

49

[ "5vbn", "6hv8", "6hv9", "6wjv", "7pfo", "7plo", "7pmk", "7pmn", "7qhs", "7z13", "8kg6", "8kg8", "8kg9", "8p5e", "8p62", "8p63", "8tw9", "8twa", "8xgc", "9b8s", "9b8t", "9nea" ]

22

[ "PUB00154339", "PUB00154453", "PUB00154454" ]

[ "30498216", "20227374", "27573199" ]

[ "Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome.", "Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.", "A novel germline POLE mutation causes an early onset cancer prone syndrome mi...

[ 2018, 2010, 2017 ]

3

[]

0

null

[ "Archaea", "Clostridia", "Eukaryota", "ecological metagenomes" ]

[ 89, 2, 4239, 4 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 1, 3, 10, 7, 1, 4, 2, 1, 1, 14 ]

12

true

Domain

DNA polymerase-epsilon, zinc finger domain

Znf-DPOE

1

IPR054476

54,476

E3 ubiquitin-protein ligase listerin, N-terminal domain

Ltn1_N

Domain

4,613

false

This domain is found at the N-terminal of E3 ubiquitin-protein ligase listerin from Saccharomyces cerevisiae (Ltn1) and similar eukaryotic proteins. Ltn1 is a component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesised na...

[]

0

[ "PFAM" ]

[ "PF22958" ]

[ "Ltn1_1st" ]

[ 4613 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-CEL-983168", "R-DDI-983168", "R-DME-983168", "R-HSA-983168", "R-MMU-983168", "R-SCE-983168", "R-SPO-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-CEL-983168", "REACTOME:R-DDI-983168", "REACTOME:R-DME-983168", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168", "REACTOME:R-SCE-983168", "REACTOME:R-SPO-983168" ]

9

[ "3j92", "5fg0", "5fg1", "8aaf", "8agt", "8agu", "8agv", "8agw", "8agx", "8agz", "9gy4", "9ofv" ]

12

[ "PUB00154051" ]

[ "27385828" ]

[ "Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits." ]

[ 2016 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4613 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 3, 1, 4, 2, 1, 4, 2, 1, 1, 8 ]

12

true

Domain

E3 ubiquitin-protein ligase listerin, N-terminal domain

Ltn1_N

2

IPR054477

54,477

E3 ubiquitin-protein ligase listerin, HEAT repeat region

LTN1_E3_ligase_6th

Domain

4,404

false

This entry represents a series of HEAT repeats from the LTN1 family of proteins. The LTN1 family consists of E3 ubiquitin-protein ligases that are integral components of the ribosome quality control complex (RQC). The RQC is a ribosome-associated complex responsible for the ubiquitination and subsequent extraction of i...

[]

0

[ "PFAM" ]

[ "PF22999" ]

[ "LTN1_E3_ligase_6th" ]

[ 4404 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-DDI-983168", "R-DME-983168", "R-HSA-983168", "R-MMU-983168", "R-SCE-983168", "R-SPO-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-DDI-983168", "REACTOME:R-DME-983168", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168", "REACTOME:R-SCE-983168", "REACTOME:R-SPO-983168" ]

8

[ "3j92", "8aaf", "8agt", "8agu", "8agv", "8agw", "8agx", "8agz", "9gy4", "9ofv" ]

10

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4404 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 6, 3, 1, 1, 1, 1, 4, 3, 1, 1, 11 ]

11

true

Domain

E3 ubiquitin-protein ligase listerin, HEAT repeat region

LTN1_E3_ligase_6th

5

IPR054478

54,478

E3 ubiquitin-protein ligase listerin, ubiquitin conjugating domain

LTN1_UBC

Domain

4,569

false

This entry represents a domain that structurally resembles the ubiquitin conjugating enzyme domain and the RWD domain . This domain is somewhat smaller and apparently lacks the conserved cysteine that is used for ubiquitin conjugation. This domain is commonly found in the LTN1 family that comprises E3 ubiquitin-protein...

[]

0

[ "PFAM" ]

[ "PF23009" ]

[ "UBC_like" ]

[ 4569 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-CEL-983168", "R-DDI-983168", "R-DME-983168", "R-HSA-983168", "R-MMU-983168", "R-SCE-983168", "R-SPO-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-CEL-983168", "REACTOME:R-DDI-983168", "REACTOME:R-DME-983168", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168", "REACTOME:R-SCE-983168", "REACTOME:R-SPO-983168" ]

9

[ "3j92", "8aaf", "8agt", "8agu", "8agv", "8agw", "8agx", "8agz", "9gy4", "9ofv" ]

10

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4569 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 3, 1, 1, 2, 1, 4, 2, 1, 1, 11 ]

12

true

Domain

E3 ubiquitin-protein ligase listerin, ubiquitin conjugating domain

LTN1_UBC

9

IPR054479

54,479

AglB-like, core domain

AglB-like_core

Domain

2,209

false

This entry represents the core domain of archaeal oligosaccharyltransferase AglB that transfers oligosaccharide chain from a lipid-linked oligosaccharide (LLO) donor to the asparagine residues in the N-glycosylation sequon, Asn-X-Ser/Thr (X=Pro) [ , , , , ]. In the archaea AlgB, it occurs alone, rather than in complex ...

[]

0

[ "PFAM" ]

[ "PF22627" ]

[ "AglB_core-like" ]

[ 2209 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.99", "R-BTA-9768727", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9768727", "R-MMU-9768727" ]

[ "EC:2.4.99", "REACTOME:R-BTA-9768727", "REACTOME:R-HSA-446203", "REACTOME:R-HSA-9694548", "REACTOME:R-HSA-9768727", "REACTOME:R-MMU-9768727" ]

6

[ "3vgp", "3vu0", "3wai", "3waj", "3wak", "5gmy", "6ftg", "6fti", "6ftj", "6s7o", "7e9s", "8b6l", "8pn9" ]

13

[ "PUB00050259", "PUB00091458", "PUB00152090", "PUB00152091", "PUB00153793" ]

[ "18046457", "23815857", "22865878", "23177926", "22559858" ]

[ "Structure-guided identification of a new catalytic motif of oligosaccharyltransferase.", "Crystal structure of the C-terminal globular domain of the third paralog of the Archaeoglobus fulgidus oligosaccharyltransferases.", "Eukaryotic N-glycosylation occurs via the membrane-anchored C-terminal domain of the St...

[ 2008, 2013, 2012, 2013, 2012 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 689, 15, 1469, 36 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 11, 4 ]

5

true

Domain

AglB-like, core domain

AglB-like_core

7

IPR054480

54,480

Acetolactate synthase small subunit-like, ACT domain

AHAS_small-like_ACT

Domain

33,795

false

This entry represents the ACT domain found at the N-terminal of acetohydroxyacid synthase isozyme III small subunit (ILVH) from Escherichia coli and at the C-terminal of D-3-phosphoglycerate dehydrogenase [ , ], which are closely related [ , , , ]. ILVH is the regulatory subunit of acetohydroxyacid synthase (AHAS), an ...

[]

0

[ "PFAM" ]

[ "PF22629" ]

[ "ACT_AHAS_ss" ]

[ 33795 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.2.1.6", "PWY-5101", "PWY-5103", "PWY-5104", "PWY-5938", "PWY-5939", "PWY-6389", "PWY-7111" ]

[ "EC:2.2.1.6", "METACYC:PWY-5101", "METACYC:PWY-5103", "METACYC:PWY-5104", "METACYC:PWY-5938", "METACYC:PWY-5939", "METACYC:PWY-6389", "METACYC:PWY-7111" ]

8

[ "1psd", "1sc6", "1y7p", "1yba", "2f1f", "2fgc", "2lvw", "2p9c", "2p9e", "2p9g", "2pa3", "2pc6", "3k5p", "5uyy", "5v0s", "5ypp", "5ypw", "5ypy", "5yum", "6lpi", "6u60", "6u9d", "6u9h", "6vz8", "6wo1" ]

25

[ "PUB00005737", "PUB00030987", "PUB00038467", "PUB00040493", "PUB00048655", "PUB00154455", "PUB00154456" ]

[ "7719856", "15035616", "15823035", "16458324", "17586771", "11243831", "22284339" ]

[ "The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase.", "Multiconformational states in phosphoglycerate dehydrogenase.", "Vmax regulation through domain and subunit changes. The active form of phosphoglycerate dehydrogenase.", "Structure of the regulatory subunit of a...

[ 1995, 2004, 2005, 2006, 2007, 2001, 2012 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviricetes", "unclassified sequences" ]

[ 736, 28902, 3663, 2, 492 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 3, 1, 9, 1, 1, 25 ]

7

true

Domain

Acetolactate synthase small subunit-like, ACT domain

AHAS_small-like_ACT

2

IPR054481

54,481

Alpha-glucan water dikinase, phosphohistidine-like domain

GWD1_pHisD

Domain

2,397

false

This domain is found in Alpha-glucan water dikinase (GWD1) and its homologues [ , , ]. This enzyme is involved in the incorporation of phosphate into starch-like alpha-V, with preferred C-6 position of glucose units. It acts as an overall regulator of starch mobilisation and it is required for starch degradation. The d...

[]

0

[ "PFAM" ]

[ "PF22973" ]

[ "GWD1_pHisD" ]

[ 2397 ]

1

[ "EC", "METACYC" ]

[ "2.7.9.4", "PWY-6724" ]

[ "EC:2.7.9.4", "METACYC:PWY-6724" ]

2

[]

0

[ "PUB00153995", "PUB00154457", "PUB00154474" ]

[ "11487701", "14525539", "28303594" ]

[ "The Arabidopsis sex1 mutant is defective in the R1 protein, a general regulator of starch degradation in plants, and not in the chloroplast hexose transporter.", "Functional characterization of alpha-glucan,water dikinase, the starch phosphorylating enzyme.", "The analysis of the different functions of starch-...

[ 2001, 2004, 2017 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 6, 2387, 4 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 6, 23 ]

3

true

Domain

Alpha-glucan water dikinase, phosphohistidine-like domain

GWD1_pHisD

8

IPR054482

54,482

Tail protein NMB1110-like, third domain

NMB1110-like_3rd

Domain

372

false

This domain is found in Tail protein, 43 kDa from Neisseria meningitidis (NMB1110) and similar sequences which are related to baseplate hub protein gp44 from Mu bacteriophage. This domain is located C-terminal to and N-terminal to .

[]

0

[ "PFAM" ]

[ "PF22630" ]

[ "NMB1110_3rd" ]

[ 372 ]

1

[]

0

[ "3d37" ]

1

[]

0

[]

0

null

[ "Caudoviricetes", "Glossina brevipalpis", "Pseudomonadati", "ecological metagenomes" ]

[ 4, 1, 365, 2 ]

4

[]

0

true

Domain

Tail protein NMB1110-like, third domain

NMB1110-like_3rd

6

IPR054483

54,483

DC1-like, C-terminal

DC1-like_CT

Domain

1,894

false

This entry represents a variation of the protein kinase C1 domain (named DC1 for divergent C1 domain) that is characterised by a rich cysteine content, found at the C-terminal of a group of uncharacterised plant proteins. This domain is involved in binding many ligands, which include diacylglycerol, phorbol esters and ...

[]

0

[ "PFAM" ]

[ "PF22926" ]

[ "C1-like_CT" ]

[ 1894 ]

1

[]

0

[]

0

[ "PUB00153838" ]

[ "35577811" ]

[ "Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists." ]

[ 2022 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1894 ]

1

[ "Arabidopsis thaliana" ]

[ 446 ]

1

true

Domain

DC1-like, C-terminal

DC1-like_CT

6

IPR054484

54,484

ComC, supersandwich domain

ComC_SSD

Domain

1,014

false

This domain is found in ComC from Dictyostelium discoideum and related proteins from Amoebozoa species. It adopts a supersandwich fold with a greater similarity to GLMP luminal domain. ComC mediates a cell adhesion pathway via regulation of the expression of the other intercellular communication genes lagC, and lagD du...

[]

0

[ "PFAM" ]

[ "PF22933" ]

[ "ComC_SSD" ]

[ 1014 ]

1

[]

0

[]

0

[ "PUB00154458" ]

[ "14651934" ]

[ "A cell-adhesion pathway regulates intercellular communication during Dictyostelium development." ]

[ 2003 ]

1

[]

0

null

[ "Dictyostelia" ]

[ 1014 ]

1

[]

0

true

Domain

ComC, supersandwich domain

ComC_SSD

4

IPR054485

54,485

Fluoroacetyl-CoA-specific thioesterase-like domain

FlK-like_dom

Domain

4,353

false

This entry includes fluoroacetyl-CoA-specific thioesterases (FlK), which catalyses the hydrolysis of fluoroacetyl-coenzyme A and provides an effective self-defence mechanism, preventing any fluoroacetyl-coenzyme A formed from being further metabolized to 4-hydroxy-trans-aconitate, an inhibitor of TCA cycle [ , ]. This ...

[]

0

[ "PFAM" ]

[ "PF22636" ]

[ "FlK" ]

[ 4353 ]

1

[]

0

[ "2cwz", "2q78", "3kuv", "3kuw", "3kv7", "3kv8", "3kvi", "3kvu", "3kvz", "3kw1", "3kx7", "3kx8", "3p2q", "3p2r", "3p2s", "3p3f", "3p3i", "3qoo" ]

18

[ "PUB00026174", "PUB00054890", "PUB00057360" ]

[ "14997554", "20430898", "20836570" ]

[ "Crystal structure of conserved protein PH1136 from Pyrococcus horikoshii.", "Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.", "Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity." ]

[ 2004, 2010, 2010 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 107, 3943, 116, 187 ]

4

[]

0

true

Domain

Fluoroacetyl-CoA-specific thioesterase-like domain

FlK-like_dom

9

IPR054488

54,488

Cyanobactin oxidase ThcOx, second domain

ThcOx_dom2

Domain

720

false

Thus entry represents the second peptide-clamp domain described in cianobactin oxidase ThcOx from Cyanothece sp. [ ]. The first one is represented in and at the C-terminal it contains a nitroreductase domain ( ) [ ]. In this domain, the binding site is buried by an interaction with the other clamp domain and thus it is...

[]

0

[ "PFAM" ]

[ "PF22767" ]

[ "ThcOx" ]

[ 720 ]

1

[]

0

[ "5lq4", "8pz5" ]

2

[ "PUB00091260" ]

[ "27841750" ]

[ "Structure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 711, 9 ]

2

[]

0

true

Domain

Cyanobactin oxidase ThcOx, second domain

ThcOx_dom2

1

IPR054490

54,490

BT_1020-like, structural beta-sandwich domain 1

BT_1020-like_b-sandwich_1

Domain

630

false

This entry represents the central structural β-sandwich domain 1 found in Six-hairpin glycosidase from Bacteroides thetaiotaomicron (BT_1020, ) and similar uncharacterised proteins mainly found in bacteroidetes [ ].

[]

0

[ "PFAM" ]

[ "PF22585" ]

[ "Sialidase-like_CBM" ]

[ 630 ]

1

[]

0

[ "5mqr", "5mqs" ]

2

[ "PUB00103952" ]

[ "28329766" ]

[ "Complex pectin metabolism by gut bacteria reveals novel catalytic functions." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 622, 8 ]

2

[]

0

true

Domain

BT_1020-like, structural beta-sandwich domain 1

BT_1020-like_b-sandwich_1

4

IPR054491

54,491

Mannosylglycerate hydrolase MGH1-like, glycoside hydrolase domain

MGH1-like_GH

Domain

18,982

false

This entry represents the glycoside hydrolase domain found in Mannosylglycerate hydrolase MGH(1/2) from Selaginella moellendorffii, Glucosidase YgjK and similar sequences from bacteria and eukaryotes. MGH1 catalyses the hydrolysis of alpha-D-mannosyl-glycerate (MG) to D-glycerate and D-mannose [ ]. Glucosidase YgjK cle...

[]

0

[ "PFAM" ]

[ "PF22422" ]

[ "MGH1-like_GH" ]

[ 18982 ]

1

[]

0

[ "2z07", "3d3i", "3w7s", "3w7t", "3w7u", "3w7w", "3w7x", "4wva", "4wvb", "4wvc", "5ca3", "5gw7", "5mqr", "5mqs", "5ohc", "5ohz", "5oi0", "5oi1", "5oie", "5oiv", "5oiw", "5oj4", "5oju", "5ojv", "5ont", "5onz", "5oo2", "6g3n", "6m5a", "6q5t", "6xux", "7pqq"...

43

[ "PUB00050905", "PUB00094228", "PUB00103952", "PUB00151327", "PUB00154459", "PUB00154477" ]

[ "18586271", "31316802", "28329766", "21149454", "23179444", "25341489" ]

[ "Structural insights into the substrate specificity and function of Escherichia coli K12 YgjK, a glucosidase belonging to the glycoside hydrolase family 63.", "The structural characterization of a glucosylglycerate hydrolase provides insights into the molecular mechanism of mycobacterial recovery from nitrogen st...

[ 2008, 2019, 2017, 2011, 2013, 2014 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 146, 15959, 2708, 1, 168 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 2, 1 ]

3

true

Domain

Mannosylglycerate hydrolase MGH1-like, glycoside hydrolase domain

MGH1-like_GH

4

IPR054492

54,492

Polysaccharide deacetylase-like

WbmS-like

Family

95

false

This family represents a group of prokaryotic proteins, including the putative polysaccharide deacetylase WbmS from Bordetella bronchiseptica ( ), which is involved in O-antigen biosynthesis. It adopts an α-β barrel configuration .

[]

0

[ "PFAM" ]

[ "PF22537" ]

[ "WbmS-like" ]

[ 95 ]

1

[]

0

[ "3hft" ]

1

[]

0

[]

0

null

[ "Bacteria", "Nitrososphaerota", "ecological metagenomes" ]

[ 85, 4, 6 ]

3

[]

0

true

Family

Polysaccharide deacetylase-like

WbmS-like

9

IPR054494

54,494

Conserved oligomeric Golgi complex subunit 2, C-terminal

COG2_C

Domain

58

false

This entry represents the C-terminal region of Conserved oligomeric Golgi complex subunit 2 from yeast, a component of the peripheral membrane COG complex involved in intra-Golgi protein trafficking. This domain adopts a six-helix bundle that seems to play an important structural role in the COG complex [ ].

[]

0

[ "PFAM" ]

[ "PF22431" ]

[ "COG2p_C" ]

[ 58 ]

1

[]

0

[ "2jqq" ]

1

[ "PUB00044936" ]

[ "17565980" ]

[ "Structural analysis of conserved oligomeric Golgi complex subunit 2." ]

[ 2007 ]

1

[]

0

null

[ "Saccharomycetaceae" ]

[ 58 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Conserved oligomeric Golgi complex subunit 2, C-terminal

COG2_C

8

IPR054495

54,495

Active DUF488-N3 subclade

DUF488-N3a

Domain

1,281

false

This entry represents a subclade of DUF488 domains with degenerate C-terminal core strand. Sometimes it is observed adjacent to the DUF488-s subclade, suggesting it preserves a catalytic activity comparable to other active DUF488 subclades [ ].

[]

0

[ "PFAM" ]

[ "PF22751" ]

[ "DUF488-N3a" ]

[ 1281 ]

1

[]

0

[]

0

[ "PUB00153826" ]

[ "36968430" ]

[ "New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts." ]

[ 2023 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Knufia peltigerae", "Viruses", "metagenomes" ]

[ 184, 1008, 1, 62, 26 ]

5

[]

0

true

Domain

Active DUF488-N3 subclade

DUF488-N3a

8

IPR054496

54,496

Baseplate hub gp41

E217_GP41

Family

1,253

false

E217 is a Pseudomonas phage used in an experimental cocktail to eradicate cystic fibrosis-associated Pseudomonas aeruginosa. Gp41 ia a baseplate cap protein that forms a complex with gp36, gp37 and gp38 proteins. These four proteins are evolutionarily related to the tail tube and adopt a similar fold, consisting of two...

[]

0

[ "PFAM" ]

[ "PF22759" ]

[ "E217_GP41" ]

[ 1253 ]

1

[]

0

[ "7yfz", "8eon", "9b45" ]

3

[ "PUB00153918" ]

[ "37422479" ]

[ "High-resolution cryo-EM structure of the Pseudomonas bacteriophage E217." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 978, 4, 265, 6 ]

4

[]

0

true

Family

Baseplate hub gp41

E217_GP41

6

IPR054497

54,497

Lytic polysaccharide monooxygenase AA14

LPMO_AA14

Family

1,365

false

This entry represents the AA14 family of lytic polysaccharide monooxygenases (LPMOs), mainly found in fungi. These enzymes cleave polysaccharides through an oxidative, instead of hydrolytic, mechanism. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H2O2 ...

[]

0

[ "PFAM" ]

[ "PF22810" ]

[ "LPMO_AA14" ]

[ 1365 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.14.99.-", "PWY-2961", "PWY-5132", "PWY-5133", "PWY-5175", "PWY-5368", "PWY-5748", "PWY-5775", "PWY-5795", "PWY-5875", "PWY-5947", "PWY-6279", "PWY-6280", "PWY-6286", "PWY-6346", "PWY-699", "PWY-7495", "PWY-7849", "PWY-7857", "PWY-8399", "PWY-8400", "PWY-8412" ]

[ "EC:1.14.99.-", "METACYC:PWY-2961", "METACYC:PWY-5132", "METACYC:PWY-5133", "METACYC:PWY-5175", "METACYC:PWY-5368", "METACYC:PWY-5748", "METACYC:PWY-5775", "METACYC:PWY-5795", "METACYC:PWY-5875", "METACYC:PWY-5947", "METACYC:PWY-6279", "METACYC:PWY-6280", "METACYC:PWY-6286", "METACYC:PWY...

22

[ "5no7" ]

1

[ "PUB00154046", "PUB00154972" ]

[ "29377002", "38395898" ]

[ "Lytic xylan oxidases from wood-decay fungi unlock biomass degradation.", "A novel AA14 LPMO from Talaromyces rugulosus with bifunctional cellulolytic/hemicellulolytic activity boosted cellulose hydrolysis." ]

[ 2018, 2024 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1365 ]

1

[]

0

true

Family

Lytic polysaccharide monooxygenase AA14

LPMO_AA14

3

IPR054498

54,498

Swiss Army Knife, 2H phosphoesterase domain

2H-SAK

Domain

577

false

The Swiss Army Knife class of proteins features a diverse domain repertoire acting to repair RNA damaged in the wake of RNase attacks. 2H-SAK is one such domain, a phosphatase of the rhodanese-phosphatase superfamily. It is predicted to 'clean' RNA ends by removing phosphate groups, preparing them for ligation by their...

[]

0

[ "PFAM" ]

[ "PF22547" ]

[ "2H-SAK" ]

[ 577 ]

1

[]

0

[]

0

[ "PUB00066726" ]

[ "22731697" ]

[ "Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 89, 471, 13, 4 ]

4

[]

0

true

Domain

Swiss Army Knife, 2H phosphoesterase domain

2H-SAK

5

IPR054499

54,499

Diels-Alderase, C-terminal domain

DA_C

Domain

503

false

This domain is found at the C-terminal of a number of fungal Diels-Alderases, including mycB, mpsD and cghA. Diels-Alderases catalyse different pericyclic [4+2] cycloaddition reactions that synthesise potential pharmaceuticals and mycotoxins [ , , , ]. These enzymes consist of two similar β-barrel domains with arrangem...

[]

0

[ "PFAM" ]

[ "PF22903" ]

[ "DA_C" ]

[ 503 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "5.5.1.-", "PWY-6094", "PWY-6193", "PWY-7669", "PWY-7702", "PWY-7811", "PWY-7941", "PWY-7945", "PWY-7946" ]

[ "EC:5.5.1.-", "METACYC:PWY-6094", "METACYC:PWY-6193", "METACYC:PWY-7669", "METACYC:PWY-7702", "METACYC:PWY-7811", "METACYC:PWY-7941", "METACYC:PWY-7945", "METACYC:PWY-7946" ]

9

[ "6kaw", "6kbc", "7dmn", "7dmo", "7e22", "7e5t", "7e5u", "7e5v" ]

8

[ "PUB00093970", "PUB00153902", "PUB00153903", "PUB00155600", "PUB00155601" ]

[ "31815421", "34056443", "34121297", "26360642", "28379186" ]

[ "Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum.", "Crystal Structures of Fsa2 and Phm7 Catalyzing [4 + 2] Cycloaddition Reactions with Reverse Stereoselectivities in Equisetin and Phomasetin Biosynthesis.", "Molecular Basis for Two...

[ 2020, 2021, 2021, 2015, 2017 ]

5

[]

0

null

[ "Bacteria", "Fungi" ]

[ 8, 495 ]

2

[]

0

true

Domain

Diels-Alderase, C-terminal domain

DA_C

2

IPR054500

54,500

Phage tail fiber repeat

Phage_fiber_rpt

Repeat

379

false

This entry represents a lasso-like repeat found in phage tail proteins from tailed bacteriophages and prophages mainly found in flavobacteria.

[]

0

[ "PFAM" ]

[ "PF22337" ]

[ "Phage_fiber_rpt" ]

[ 379 ]

1

[]

0

[ "4mtm" ]

1

[]

0

[]

0

null

[ "Bacteria", "Cylicocyclus nassatus", "Methanobacteriota", "Viruses", "bioreactor metagenome" ]

[ 291, 1, 4, 82, 1 ]

5

[]

0

true

Repeat

Phage tail fiber repeat

Phage_fiber_rpt

1

IPR054501

54,501

NACHT conflict system, C-terminal helical domain 2

NCH2

Domain

644

false

This is an helical domain found at the C-terminal of bacterial NACHT conflict systems [ ].

[]

0

[ "PFAM" ]

[ "PF22727" ]

[ "NCH2" ]

[ 644 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 643, 1 ]

2

[]

0

true

Domain

NACHT conflict system, C-terminal helical domain 2

NCH2

3

IPR054502

54,502

Plant bHLH transcription factor, ACT-like domain

bHLH-TF_ACT-like_plant

Domain

21,667

false

This entry represents an ACT-like domain found at the C-terminal of plant transcription factors, such as transcription factor GLABRA 3 from Arabidopsis and the bHLH transcription factor ( ) from maize, which is associated with bHLH domains. This domain association is unique to the kingdom Plantae [ ]. Phylogenetic anal...

[]

0

[ "PFAM" ]

[ "PF22754" ]

[ "bHLH-TF_ACT-like_plant" ]

[ 21667 ]

1

[]

0

[ "9c7n", "9c7o" ]

2

[ "PUB00153833" ]

[ "37126718" ]

[ "Evolution and diversification of the ACT-like domain associated with plant basic helix-loop-helix transcription factors." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 20, 21638, 9 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 172, 88, 153 ]

3

true

Domain

Plant bHLH transcription factor, ACT-like domain

bHLH-TF_ACT-like_plant

6

IPR054503

54,503

Lysine-specific demethylase 3A/B, tudor domain

KDM3AB_Tudor

Domain

3,753

false

This domain is found in Lysine-specific demethylase 3B (KDM3B, also known as JmjC domain-containing histone demethylation protein 2B or JHDM2B), Lysine-specific demethylase 3A (KDM3A, also known as JmjC domain-containing histone demethylation protein 2A or JHDM2A) and related proteins. KDM3B is a histone demethylase th...

[]

0

[ "PFAM" ]

[ "PF22987" ]

[ "Tudor_KDM3B" ]

[ 3753 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.11.65", "R-HSA-3214842", "R-HSA-9029569", "R-HSA-983231", "R-MMU-3214842", "R-MMU-983231", "R-RNO-3214842" ]

[ "EC:1.14.11.65", "REACTOME:R-HSA-3214842", "REACTOME:R-HSA-9029569", "REACTOME:R-HSA-983231", "REACTOME:R-MMU-3214842", "REACTOME:R-MMU-983231", "REACTOME:R-RNO-3214842" ]

7

[]

0

[ "PUB00153916", "PUB00154027" ]

[ "16603237", "34099688" ]

[ "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.", "A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation." ]

[ 2006, 2021 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3753 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 60, 9, 9, 13 ]

4

true

Domain

Lysine-specific demethylase 3A/B, tudor domain

KDM3AB_Tudor

6

IPR054504

54,504

Lysine-specific demethylase 3B, PWWP domain

PWWP_KDM3B

Domain

3,175

false

This domain is found in Lysine-specific demethylase 3B (KDM3B, also known as JmjC domain-containing histone demethylation protein 2B or JHDM2B), Lysine-specific demethylase 3A (KDM3A, also known as JmjC domain-containing histone demethylation protein 2A or JHDM2A) and related proteins. KDM3B is a histone demethylase th...

[]

0

[ "PFAM" ]

[ "PF22988" ]

[ "PWWP_KDM3B" ]

[ 3175 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.11.65", "R-HSA-3214842", "R-HSA-9029569", "R-HSA-983231", "R-MMU-3214842", "R-MMU-983231", "R-RNO-3214842" ]

[ "EC:1.14.11.65", "REACTOME:R-HSA-3214842", "REACTOME:R-HSA-9029569", "REACTOME:R-HSA-983231", "REACTOME:R-MMU-3214842", "REACTOME:R-MMU-983231", "REACTOME:R-RNO-3214842" ]

7

[]

0

[ "PUB00153916" ]

[ "16603237" ]

[ "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3175 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 27, 8, 9, 12 ]

4

true

Domain

Lysine-specific demethylase 3B, PWWP domain

PWWP_KDM3B

9

IPR054505

54,505

Myb-like DNA-binding domain

Myb_DNA-bind_8

Domain

2,867

false

This entry represents a Myb-like domain. These are short DNA-binding domains.

[]

0

[ "PFAM" ]

[ "PF22980" ]

[ "Myb_DNA-bind_8" ]

[ 2867 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Ascomycota", "Bacteria" ]

[ 2861, 6 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

Myb-like DNA-binding domain

Myb_DNA-bind_8

9

IPR054506

54,506

STICHEL, DnaA_N-like alpha-beta domain

DnaA_N-like_STI

Domain

2,989

false

This domain is found in protein STICHEL (STI) from Arabidopsis thaliana and related proteins from plants and cyanobacteria. STICHEL acts as a key regulator of trichome branching through an endoreduplication-independent pathway [ ]. The domain represented by this entry is predicted to adopt a globular α/β structure with...

[]

0

[ "PFAM" ]

[ "PF23007" ]

[ "DnaA_N-like_STI" ]

[ 2989 ]

1

[]

0

[]

0

[ "PUB00101309" ]

[ "12586888" ]

[ "The Arabidopsis STICHEL gene is a regulator of trichome branch number and encodes a novel protein." ]

[ 2003 ]

1

[]

0

null

[ "Cyanobacteriota", "Streptophytina" ]

[ 319, 2670 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 25, 16, 53 ]

3

true

Domain

STICHEL, DnaA_N-like alpha-beta domain

DnaA_N-like_STI

1

IPR054507

54,507

CGL2689-like, C-terminal domain

CGL2689-like_C

Domain

104

false

This entry represents the α-helical C-terminal domain of CGL2689 from Corynebacterium glutamicum ( , ) and similar sequences from actinomycetes. CGL2689 is a putative dehydrogenase that contain an N-terminal Rossmann domain ( ). This domain is involved in dimerisation by swapping of helices along a central long α-helix...

[]

0

[ "PFAM" ]

[ "PF22242" ]

[ "6PGD_like" ]

[ 104 ]

1

[]

0

[ "3dfu" ]

1

[]

0

[]

0

null

[ "Corynebacterium" ]

[ 104 ]

1

[]

0

true

Domain

CGL2689-like, C-terminal domain

CGL2689-like_C

2

IPR054509

54,509

Leucine--tRNA ligase, ubiquitin-like domain

LARS1_ULD

Domain

1,829

false

This domain is found in human Leucine--tRNA ligase (LARS1) and related metazoan proteins. LARS1 is aminoacyl-tRNA synthetase that catalyses the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) [ , ]. It also mediates activation of leucine-dependent mechanistic target of rapamycin complex 1 (mTORC1). In th...

[]

0

[ "PFAM" ]

[ "PF22947" ]

[ "ULD_3" ]

[ 1829 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.1.1.4", "R-HSA-2408522", "R-HSA-379716", "R-HSA-9856649", "R-MMU-9856649" ]

[ "EC:6.1.1.4", "REACTOME:R-HSA-2408522", "REACTOME:R-HSA-379716", "REACTOME:R-HSA-9856649", "REACTOME:R-MMU-9856649" ]

5

[ "6kid", "6kqy", "6kr7" ]

3

[ "PUB00154460", "PUB00154461", "PUB00154462" ]

[ "25051973", "32232361", "33910001" ]

[ "A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity.", "Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.", "Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activati...

[ 2014, 2020, 2021 ]

3

[]

0

null

[ "Metazoa" ]

[ 1829 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 15, 4, 3 ]

6

true

Domain

Leucine--tRNA ligase, ubiquitin-like domain

LARS1_ULD

1

IPR054510

54,510

Tm0771-like, C-terminal domain

Tm0771-like_C

Domain

27

false

This entry represents the C-terminal domain of Tm0771 from Thermotoga maritima, a DNA polymerase III, gamma subunit-related protein. This domain consists of a five α-helix bundle ( ). Members of this entry are specific to Thermotogales.

[]

0

[ "PFAM" ]

[ "PF22227" ]

[ "DNA_pol3_gamma_R_C" ]

[ 27 ]

1

[]

0

[ "2gno" ]

1

[]

0

[]

0

null

[ "Thermotogales" ]

[ 27 ]

1

[]

0

true

Domain

Tm0771-like, C-terminal domain

Tm0771-like_C

1

IPR054511

54,511

RNAP inhibitory protein/P131-like

RIP_P131-like

Family

9

false

This entry represents a family of viral proteins, including RNAP Inhibitory Protein (RIP) and its paralogue, the major capsid protein (MCP) P131, both from Acidianus two-tailed virus. These proteins adopt very similar bundle structures consisting of six α-helices [ , ]. RIP factor binds inside the DNA-binding channel o...

[]

0

[ "PFAM" ]

[ "PF22238" ]

[ "RIP_P131-like" ]

[ 9 ]

1

[]

0

[ "3faj", "5eqw", "7oq4" ]

3

[ "PUB00154210", "PUB00154211" ]

[ "29440399", "34535646" ]

[ "Structural studies of Acidianus tailed spindle virus reveal a structural paradigm used in the assembly of spindle-shaped viruses.", "Structural basis of RNA polymerase inhibition by viral and host factors." ]

[ 2018, 2021 ]

2

[]

0

null

[ "Bicaudaviridae", "Sulfolobus acidocaldarius" ]

[ 5, 4 ]

2

[]

0

true

Family

RNAP inhibitory protein/P131-like

RIP_P131-like

1

IPR054512

54,512

DD-carboxypeptidase/endopeptidase Mpg-like, N-terminal

NMB0315-like_N

Domain

667

false

This entry represents the N-terminal domain I of DD-carboxypeptidase/endopeptidase Mpg (NMB0315), an outer membrane protein of Neisseria meningitidis serogroup B and a potential candidate for a broad-spectrum vaccine against meningococcal disease. This domain tightly associates with domain III, which blocks the active ...

[]

0

[ "PFAM" ]

[ "PF22310" ]

[ "NMB0315_dom_I" ]

[ 667 ]

1

[ "EC", "EC", "METACYC" ]

[ "3.4.17.-", "3.4.24.-", "PWY-8119" ]

[ "EC:3.4.17.-", "EC:3.4.24.-", "METACYC:PWY-8119" ]

3

[ "3slu", "6muk" ]

2

[ "PUB00059052" ]

[ "22046377" ]

[ "Crystal structure of outer membrane protein NMB0315 from Neisseria meningitidis." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 657, 10 ]

2

[]

0

true

Domain

DD-carboxypeptidase/endopeptidase Mpg-like, N-terminal

NMB0315-like_N

7

IPR054514

54,514

RhiE-like, KS-MAT linker domain

RhiE-like_linker

Domain

3,935

false

This entry represents a linker domain found in polyketide synthases from ascomycetes and bacteria. This domain connects the N-terminal domains with the B-domain as described in RhiE ( ) [ , , ].

[]

0

[ "PFAM" ]

[ "PF22336" ]

[ "RhiE-like_linker" ]

[ 3935 ]

1

[]

0

[ "4kc5", "4na1", "4na2", "4na3", "4qyr", "4tkt", "4z37", "5e5n", "5e6k", "5elp", "5eny", "5erb", "5erf", "6mhk", "6mhl", "7s2x", "7zm9", "7zma", "7zmc", "7zmd", "7zsk", "8oii" ]

22

[ "PUB00153896", "PUB00153897", "PUB00154203", "PUB00154204" ]

[ "24048471", "24508341", "26420866", "26724270" ]

[ "Vinylogous chain branching catalysed by a dedicated polyketide synthase module.", "A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.", "Structural and evolutionary relationships of \"AT-less\" type I polyketide synthase ketosynthases.", "The LINKS motif zippers trans-ac...

[ 2013, 2014, 2015, 2016 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3659, 271, 5 ]

3

[]

0

true

Domain

RhiE-like, KS-MAT linker domain

RhiE-like_linker

6

IPR054515

54,515

YgxA-like, substrate binding domain

YgxA-like_substrate-bd

Domain

1,174

false

This entry represents the substrate binding domain of the uncharacterised protein YgxA from Bacillus subtilis and similar sequences from firmicutes. This domain consists of four-helical up-and-down bundle .

[]

0

[ "PFAM" ]

[ "PF22339" ]

[ "YgxA-like_sub_bind" ]

[ 1174 ]

1

[]

0

[ "3c18" ]

1

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis" ]

[ 1173, 1 ]

2

[]

0

true

Domain

YgxA-like, substrate binding domain

YgxA-like_substrate-bd

7

IPR054516

54,516

Cell-shape determining Csd6, N-terminal dimerization domain

Csd6-like_dimerization

Domain

180

false

This entry represents the dimerization domain found at the N terminus of Cds6 from H. pylori, a cell shape-determining protein that plays key roles in alteration of cross-linking or by trimming of peptidoglycan muropeptides. It is also involved in deglycosylation of the flagellar protein FlaA [ ]. Members of this group...

[]

0

[ "PFAM" ]

[ "PF22401" ]

[ "Csd6-like_dimeriz" ]

[ 180 ]

1

[]

0

[ "4xzz", "4y4v" ]

2

[ "PUB00143415" ]

[ "26306031" ]

[ "The Cell Shape-determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of L,D-Carboxypeptidase." ]

[ 2015 ]

1

[]

0

null

[ "Campylobacterales" ]

[ 180 ]

1

[]

0

true

Domain

Cell-shape determining Csd6, N-terminal dimerization domain

Csd6-like_dimerization

5

IPR054517

54,517

CPC1/SPEF2 domain D5

SPEF2_D5

Domain

1,710

false

This domain is found in the axoneme central apparatus (CA) associated proteins such as Chlamydomonas Central pair complex 1 (CPC1, ) and its mammalian orthologues Sperm flagellar protein 2 (SPEF2) [ , ]. CPC1 is located at C1 microtubule. Most of the distal components of the C1b projection bind CPC1 and its correct rec...

[]

0

[ "PFAM" ]

[ "PF22946" ]

[ "SPEF2_D5" ]

[ 1710 ]

1

[]

0

[ "7n6g", "7sqc", "9ijj" ]

3

[ "PUB00153933", "PUB00153934", "PUB00154240", "PUB00154241" ]

[ "35578023", "35578022", "15292403", "31545650" ]

[ "Ciliary central apparatus structure reveals mechanisms of microtubule patterning.", "Cryo-EM structure of an active central apparatus.", "Cpc1, a Chlamydomonas central pair protein with an adenylate kinase domain.", "SPEF2- and HYDIN-Mutant Cilia Lack the Central Pair-associated Protein SPEF2, ...

[ 2022, 2022, 2004, 2020 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1710 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 4, 4, 4 ]

4

true

Domain

CPC1/SPEF2 domain D5

SPEF2_D5

3

IPR054518

54,518

Phosphatidylserine Lipase ABHD16, N-terminal domain

ABHD16_N

Domain

1,623

false

This entry represents the N-terminal domain from ABHD16 family of proteins. The ABHD16 family comprises enzymes with phosphatidylserine lipase activity, catalysing the hydrolysis of phosphatidylserine to produce lysophosphatidylserine, a signaling lipid involved in immunological and neurological processes. These enzyme...

[]

0

[ "PFAM" ]

[ "PF22990" ]

[ "ABHD16_N" ]

[ 1623 ]

1

[ "EC", "METACYC" ]

[ "3.1.1.23", "PWY-7420" ]

[ "EC:3.1.1.23", "METACYC:PWY-7420" ]

2

[]

0

[]

0

[]

0

null

[ "Opisthokonta", "bird metagenome" ]

[ 1622, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 6, 2, 10 ]

6

true

Domain

Phosphatidylserine Lipase ABHD16, N-terminal domain

ABHD16_N

3

IPR054519

54,519

Integrator complex subunit 7, C-terminal domain

INTS7_C

Domain

1,863

false

This entry represents the C-terminal domain of the Integrator complex subunit 7 (INTS7). Integrator complex subunit 7 (INTS7) is a component of the integrator complex which is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of ...

[]

0

[ "PFAM" ]

[ "PF22965" ]

[ "INTS7_C" ]

[ 1863 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6807505", "R-DME-6807505", "R-DRE-6807505", "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-BTA-6807505", "REACTOME:R-DME-6807505", "REACTOME:R-DRE-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

5

[ "7cun", "7pks", "7ycx", "8rbx", "8rbz", "8rc4", "8yjb", "9vd9" ]

8

[ "PUB00035147", "PUB00045283", "PUB00053803", "PUB00077569", "PUB00077570", "PUB00152015", "PUB00154024" ]

[ "12529635", "16239144", "12006978", "15716491", "19326441", "33243860", "27427483" ]

[ "Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.", "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.", "Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate dev...

[ 2003, 2005, 2002, 2005, 2009, 2020, 2016 ]

7

[]

0

null

[ "Eukaryota" ]

[ 1863 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 2, 2, 4 ]

6

true

Domain

Integrator complex subunit 7, C-terminal domain

INTS7_C

2

IPR054520

54,520

Type II methyltransferase M.Eco57I, C-terminal domain

M_Eco57I_C

Domain

1,638

false

This domain is found at the C-terminal of the gamma subtype methylase Type II methyltransferase M.Eco57I from Escherichia coli and other related methytransferases. This domain is predicted to adopt an α-β configuration and is often found associated with .

[]

0

[ "PFAM" ]

[ "PF22837" ]

[ "M_Eco57I_C" ]

[ 1638 ]

1

[ "EC" ]

[ "2.1.1.72" ]

[ "EC:2.1.1.72" ]

1

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Rotaria sordida", "Siphoviridae sp. ctLgc23", "metagenomes" ]

[ 151, 1461, 1, 1, 24 ]

5

[]

0

true

Domain

Type II methyltransferase M.Eco57I, C-terminal domain

M_Eco57I_C

8

IPR054521

54,521

Heme-regulated eIF-2-alpha kinase, helical domain

HRI2_3H

Domain

1,760

false

This domain is found at the N-terminal of Heme-regulated eIF-2-alpha kinase (HRI1/HRI2). This enzyme phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions [ ]. HRI is a key activator of the integrated stress response (ISR) required f...

[]

0

[ "PFAM" ]

[ "PF22949" ]

[ "HRI2_3H" ]

[ 1760 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-HSA-9648895", "R-HSA-9840373", "R-MMU-9840373", "R-RNO-9840373" ]

[ "EC:2.7.11.1", "REACTOME:R-HSA-9648895", "REACTOME:R-HSA-9840373", "REACTOME:R-MMU-9840373", "REACTOME:R-RNO-9840373" ]

5

[]

0

[ "PUB00154016", "PUB00154017" ]

[ "32132706", "32132707" ]

[ "A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.", "Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway." ]

[ 2020, 2020 ]

2

[]

0

null

[ "Eukaryota", "Klosneuvirus KNV1", "seawater metagenome" ]

[ 1758, 1, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 5, 2, 2, 3, 2 ]

5

true

Domain

Heme-regulated eIF-2-alpha kinase, helical domain

HRI2_3H

7

IPR054522

54,522

Cadherin-related hmr-1, C-terminal

Hmr1_C

Domain

58

false

This entry represents the C-terminal region of Cadherin-related hmr-1 from Caenorhabditis elegans and similar sequences from nematodes. Hmr-1 is a calcium-dependent cell adhesion protein [ , ] required for adherens junction assembly and connecting adherens junctions to the cytoskeleton [ ]. This domain is homologous to...

[]

0

[ "PFAM" ]

[ "PF22417" ]

[ "Hmr1_E-cad-like" ]

[ 58 ]

1

[]

0

[ "4r10", "4r11" ]

2

[ "PUB00078905", "PUB00154009", "PUB00154467" ]

[ "25938815", "25850673", "26412237" ]

[ "An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity.", "A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo.", "ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions." ]

[ 2015, 2015, 2015 ]

3

[]

0

null

[ "Rhabditida" ]

[ 58 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

Cadherin-related hmr-1, C-terminal

Hmr1_C

1

IPR054523

54,523

Complement regulator-acquiring surface protein 2-like

CRASP-2-like

Family

53

false

This protein family includes Complement regulator-acquiring surface protein 2 from Borreliella burgdorferi (CRASP-2, also known as CspZ, ), the causative agent of Lyme disease. CRASP-2 can bind both the major alternative pathway complement regulator factor H (CFH) and factor H-like protein 1 (CFHL-1), contributing to t...

[]

0

[ "PFAM" ]

[ "PF22487" ]

[ "CRASP-2" ]

[ 53 ]

1

[]

0

[ "4bg0", "4cbe", "6atg", "7zjj", "7zjk", "7zjm", "9f1v", "9f21", "9f7i" ]

9

[ "PUB00153892" ]

[ "24702793" ]

[ "Structural characterization of CspZ, a complement regulator factor H and FHL-1 binding protein from Borrelia burgdorferi." ]

[ 2014 ]

1

[]

0

null

[ "Borreliaceae" ]

[ 53 ]

1

[]

0

true

Family

Complement regulator-acquiring surface protein 2-like

CRASP-2-like

1

IPR054524

54,524

Ssol_1539-like, N-teminal, second subdomain

Ssol_1539-like_N_2

Domain

21

false

This domain is found in Ssol_1539 from Saccharolobus solfataricus and similar archaeal sequences. Ssol_1539 is organised into two domains . The N-terminal domain contains two subdomains separated by a central helix. This entry represents the second subdomain, which shows an all-α configuration [ ].

[]

0

[ "PFAM" ]

[ "PF22445" ]

[ "Ssol_1539-like_2nd" ]

[ 21 ]

1

[]

0

[ "5k5a", "5k5d" ]

2

[ "PUB00136439" ]

[ "26339031" ]

[ "Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages." ]

[ 2015 ]

1

[]

0

null

[ "Sulfolobaceae" ]

[ 21 ]

1

[]

0

true

Domain

Ssol_1539-like, N-teminal, second subdomain

Ssol_1539-like_N_2

2

IPR054525

54,525

DEAD box helicase Hera, RNA-binding domain

Hera_RBD

Domain

71

false

This entry represents the RNA binding domain found at the C-terminal end of DEAD box helicase Hera from Thermus thermophilus and similar proteins from Deinococci. This domain, which is located C-terminal to the dimerisation domain ( ), is responsible for binding of Hera to 23S rRNA. It consists of a central four-strand...

[]

0

[ "PFAM" ]

[ "PF22231" ]

[ "Hera_RBD" ]

[ 71 ]

1

[]

0

[ "3i31", "3i32", "4i67", "4i68", "4i69", "5mao" ]

6

[ "PUB00058544", "PUB00067185" ]

[ "19710183", "23625962" ]

[ "The Thermus thermophilus DEAD box helicase Hera contains a modified RNA recognition motif domain loosely connected to the helicase core.", "Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera." ]

[ 2009, 2013 ]

2

[]

0

null

[ "Deinococci" ]

[ 71 ]

1

[]

0

true

Domain

DEAD box helicase Hera, RNA-binding domain

Hera_RBD

5

IPR054526

54,526

VtrC-like

Family

32

false

This entry represents a family of proteins specific to Vibrionaceae, including the Vibrio parahaemolyticus VtrC protein, which shows a lipocalin-like β-barrel configuration [ ]. VtrC, along with VtrA and VtrB, are required for activating the virulence type III secretion system 2 in response to bile salts. The VtrA/VtrC...

[]

0

[ "PFAM" ]

[ "PF22280" ]

[ "VtrC" ]

[ 32 ]

1

[]

0

[ "5kev", "5kew", "8dml" ]

3

[ "PUB00154328", "PUB00154473" ]

[ "27377244", "36894018" ]

[ "Bile salt receptor complex activates a pathogenic type III secretion system.", "Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus." ]

[ 2016, 2023 ]

2

[]

0

null

[ "Vibrionaceae" ]

[ 32 ]

1

[]

0

true

Family

VtrC-like

9

IPR054527

54,527

BCE_2095-like, N-terminal domain

BCE_2095-like_N

Domain

408

false

This is the N-terminal domain found in a group of uncharacterised bacterial proteins which have a Phospholipase/carboxylesterase/thioesterase domain ( ) at the C-terminal, including BCE_2095 from Bacillus cereus whose structure was determined ( , ). This domain consists of armadillo (ARM) repeats.

[]

0

[ "PFAM" ]

[ "PF22316" ]

[ "ABhydrolase-like_N" ]

[ 408 ]

1

[]

0

[ "5f2h" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eutreptiella gymnastica", "marine sediment metagenome" ]

[ 400, 4, 4 ]

3

[]

0

true

Domain

BCE_2095-like, N-terminal domain

BCE_2095-like_N

7

IPR054528

54,528

TcaA protein NTF2-like domain

TcaA_5th

Domain

1,237

false

This entry represents the C-terminal domain of the TcaA protein. TcaA plays a major role in decreasing resistance to glycopeptide antibiotics [ , ]. This domain has an NTF2-like fold. This suggests this domain could have an enzymatic function.

[]

0

[ "PFAM" ]

[ "PF22819" ]

[ "TcaA_5th" ]

[ 1237 ]

1

[]

0

[]

0

[ "PUB00054615", "PUB00154262", "PUB00154468" ]

[ "15155184", "37401629", "11042376" ]

[ "tcaA inactivation increases glycopeptide resistance in Staphylococcus aureus.", "Extensive remodelling of the cell wall during the development of Staphylococcus aureus bacteraemia.", "Inactivation of a novel three-cistronic operon tcaR-tcaA-tcaB increases teicoplanin resistance in Staphylococcus aureus....

[ 2004, 2023, 2000 ]

3

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "human gut metagenome" ]

[ 1234, 1, 2 ]

3

[]

0

true

Domain

TcaA protein NTF2-like domain

TcaA_5th

4

IPR054529

54,529

TcaA, second domain

TcaA_2nd

Domain

1,489

false

This entry represents the second domain of the TcaA proteins. TcaA plays a major role in decreasing resistance to glycopeptide antibiotics [ , , ].

[]

0

[ "PFAM" ]

[ "PF22813" ]

[ "TcaA_2nd" ]

[ 1489 ]

1

[]

0

[]

0

[ "PUB00054615", "PUB00154262", "PUB00154468" ]

[ "15155184", "37401629", "11042376" ]

[ "tcaA inactivation increases glycopeptide resistance in Staphylococcus aureus.", "Extensive remodelling of the cell wall during the development of Staphylococcus aureus bacteraemia.", "Inactivation of a novel three-cistronic operon tcaR-tcaA-tcaB increases teicoplanin resistance in Staphylococcus aureus....

[ 2004, 2023, 2000 ]

3

[]

0

null

[ "Bacteria", "Natranaeroarchaeum aerophilus" ]

[ 1488, 1 ]

2

[]

0

true

Domain

TcaA, second domain

TcaA_2nd

3

IPR054530

54,530

TcaA, 4th domain

TcaA_4th

Domain

1,665

false

This entry represents the fourth domain of the TcaA proteins that adopt an Ig-like fold. TcaA plays a major role in decreasing resistance to glycopeptide antibiotics [ , , ]. In the uncharacterised membrane protein YvbJ, thi entry covers the third and fourth domains.

[]

0

[ "PFAM" ]

[ "PF22820" ]

[ "TcaA_3rd_4th" ]

[ 1665 ]

1

[]

0

[]

0

[ "PUB00054615", "PUB00154262", "PUB00154468" ]

[ "15155184", "37401629", "11042376" ]

[ "tcaA inactivation increases glycopeptide resistance in Staphylococcus aureus.", "Extensive remodelling of the cell wall during the development of Staphylococcus aureus bacteraemia.", "Inactivation of a novel three-cistronic operon tcaR-tcaA-tcaB increases teicoplanin resistance in Staphylococcus aureus....

[ 2004, 2023, 2000 ]

3

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 1662, 1, 2 ]

3

[]

0

true

Domain

TcaA, 4th domain

TcaA_4th

5

IPR054532

54,532

TPL/SMU1, LisH-like dimerisation domain

TPL_SMU1_LisH-like

Domain

9,090

false

This entry represents a highly conserved domain containing a lissencephaly homologous (LisH) dimerisation motif found at the N-terminal end of a group of eukaryotic proteins, including Protein TOPLESS from Arabidopsis thaliana (TPL, [ ]) and human WD40 repeat-containing protein SMU1 [ , ]. TPL is a transcriptional core...

[]

0

[ "PFAM" ]

[ "PF17814" ]

[ "LisH_TPL" ]

[ 9090 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-72163", "R-DME-9861718", "R-DRE-9861718", "R-HSA-72163", "R-HSA-9861718", "R-MMU-72163", "R-MMU-9861718", "R-RNO-72163", "R-XTR-9861718" ]

[ "REACTOME:R-BTA-72163", "REACTOME:R-DME-9861718", "REACTOME:R-DRE-9861718", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-9861718", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-9861718", "REACTOME:R-RNO-72163", "REACTOME:R-XTR-9861718" ]

9

[ "4zhe", "5c6q", "5c6v", "5c7e", "5c7f", "5en6", "5en7", "5en8", "5j9k", "5ja5", "5jgc", "5jhp", "5nqs", "5nqv", "5o9z", "6ahd", "6q8f", "6q8i", "6q8j", "7wej", "7wek", "8h6k", "8h6l", "8qbn", "8qe8", "8qo9", "8qzs" ]

27

[ "PUB00074663", "PUB00090272", "PUB00095257", "PUB00138298", "PUB00154294" ]

[ "23034631", "28781166", "25378179", "26601214", "31076555" ]

[ "APETALA2 negatively regulates multiple floral organ identity genes in Arabidopsis by recruiting the co-repressor TOPLESS and the histone deacetylase HDA19.", "Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.", "The molecular mechanism of sporocyteless/nozzle in controlling Arabidop...

[ 2012, 2017, 2015, 2015, 2019 ]

5

[]

0

null

[ "Eukaryota" ]

[ 9090 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 28, 1, 5, 3, 12, 8, 5, 10, 75 ]

9

true

Domain

TPL/SMU1, LisH-like dimerisation domain

TPL_SMU1_LisH-like

1

IPR054533

54,533

Histone-lysine methyltransferase SETD7, N-terminal

SETD7_N

Domain

999

false

This entry includes histone-lysine N-methyltransferase SETD7 (also known as SET7/9) which specifically monomethylate Lys-4 of histone H3, creating a specific tag for epigenetic transcriptional activation [ , , , , ]. This entry represents the N-terminal region, which consists of MORN repeats. This entry represents hist...

[]

0

[ "PFAM" ]

[ "PF22648" ]

[ "SET7_N" ]

[ 999 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "2.1.1.364", "R-HSA-3214841", "R-MMU-3214841" ]

[ "EC:2.1.1.364", "REACTOME:R-HSA-3214841", "REACTOME:R-MMU-3214841" ]

3

[ "1h3i", "1mt6", "1muf", "1n6a", "1n6c", "1o9s", "1xqh", "2f69", "3cbm", "3cbo", "3cbp", "3m53", "3m54", "3m55", "3m56", "3m57", "3m58", "3m59", "3m5a", "3os5", "3vuz", "3vv0", "4e47", "4j7f", "4j7i", "4j83", "4j8o", "4jds", "4jlg", "5ayf", "5eg2", "5ylt"...

32

[ "PUB00018236", "PUB00027453", "PUB00027572", "PUB00032493", "PUB00040554", "PUB00044656", "PUB00103776" ]

[ "12372304", "12389038", "12514135", "15525938", "16415881", "18391193", "16141209" ]

[ "Crystal structure and functional analysis of the histone methyltransferase SET7/9.", "The active site of the SET domain is constructed on a knot.", "Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet.", "Regulation of p53 activity through lysine methylation.", "Structura...

[ 2002, 2002, 2003, 2004, 2006, 2008, 2005 ]

7

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 995 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1, 4 ]

4

true

Domain

Histone-lysine methyltransferase SETD7, N-terminal

SETD7_N

8

IPR054534

54,534

EST1-like, DNA-binding domain

EST1-like_DNA_bind

Domain

48

false

This entry represents a DNA/RNA binding domain found in a group of worm sequences, such as from C.elegans [ ], which are related to Est1A from human (SMG6), defined as 14-3-3-like proteins involved in nonsense-mediated mRNA decay (NMD) pathway.

[]

0

[ "PFAM" ]

[ "PF22695" ]

[ "EST1-like_DNA_bind" ]

[ 48 ]

1

[]

0

[ "3zhe" ]

1

[ "PUB00153928" ]

[ "23348841" ]

[ "An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay." ]

[ 2013 ]

1

[]

0

null

[ "Rhabditida" ]

[ 48 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

EST1-like, DNA-binding domain

EST1-like_DNA_bind

3

IPR054535

54,535

HphA, N-terminal heme-binding domain

HphA_N

Domain

476

false

HphA (heme scavenger) is a secreted hemophore that binds and acquires heme from hemoglobin. It consists of two domains: N-terminal heme binding domain (this entry) and C-terminal β-barrel that is related to domains members of the Outer membrane β-barrel superfamily. The N-terminal domain has a clamp-like structure cons...

[]

0

[ "PFAM" ]

[ "PF22828" ]

[ "HphA_N" ]

[ 476 ]

1

[]

0

[ "6om5", "7re4", "7rea", "7red", "8glo", "8gm3", "8gmm" ]

7

[ "PUB00154014" ]

[ "34725337" ]

[ "A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii." ]

[ 2021 ]

1

[]

0

null

[ "Bacteria", "Chaetothyriales", "marine sediment metagenome" ]

[ 472, 2, 2 ]

3

[]

0

true

Domain

HphA, N-terminal heme-binding domain

HphA_N

7

IPR054536

54,536

HphA, C-terminal domain

HphA_C

Domain

507

false

HphA (heme scavenger) is a secreted hemophore that binds and acquires heme from hemoglobin. It consists of two domains: N-terminal heme binding domain and C-terminal β-barrel (this entry) that is related to domains members of the Outer membrane β-barrel superfamily [ ].

[]

0

[ "PFAM" ]

[ "PF22829" ]

[ "HphA_C" ]

[ 507 ]

1

[]

0

[ "6om5", "7re4", "7rea", "7red", "8glo", "8gm3", "8gmm" ]

7

[ "PUB00154014" ]

[ "34725337" ]

[ "A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii." ]

[ 2021 ]

1

[ "IPR054843" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "marine sediment metagenome" ]

[ 502, 3, 2 ]

3

[]

0

true

Domain

HphA, C-terminal domain

HphA_C

3

IPR054537

54,537

Headcase, N-terminal

HECA_N

Domain

1,552

false

This domain is found towards the N-terminal of Drosophila headcase protein [ ] and the human headcase protein homologue. Drosophila headcase protein is involved in dendrite pruning [ ] and is a branching inhibitor during tracheal development [ ]. It also promotes cell survival and niche maintenance in the Drosophila te...

[]

0

[ "PFAM" ]

[ "PF15353" ]

[ "HECA_N" ]

[ 1552 ]

1

[]

0

[]

0

[ "PUB00059939", "PUB00059940", "PUB00076484", "PUB00076485", "PUB00076486", "PUB00076487", "PUB00154470" ]

[ "8575315", "11696983", "11463742", "23874487", "23197702", "19643820", "22100912" ]

[ "headcase, an imaginal specific gene required for adult morphogenesis in Drosophila melanogaster.", "Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer.", "A novel stop codon readt...

[ 1995, 2001, 2001, 2013, 2012, 2009, 2012 ]

7

[]

0

null

[ "Eukaryota" ]

[ 1552 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 1, 1, 2 ]

6

true

Domain

Headcase, N-terminal

HECA_N

4

IPR054538

54,538

F1F0 ATP synthase subunit ASA5

ASA5

Family

21

false

This entry represents the homologues of mitochondrial F1F0 ATP synthase subunit ASA5. F0 has six transmembrane helices and four long, membrane-intrinsic helices, which form the two helical hairpins of the conserved alpha subunit. Of the six transmembrane helices, two belong to ASA6 and one each to ASA5, ASA8, ASA9, and...

[]

0

[ "PFAM" ]

[ "PF22804" ]

[ "ASA5" ]

[ 21 ]

1

[]

0

[ "6rd4", "6rd5", "6rd7", "6rd8", "6rd9", "6rda", "6rdc", "6rdd", "6rdf", "6rdh", "6rdi", "6rdk", "6rdl", "6rdn", "6rdo", "6rdq", "6rdr", "6rdt", "6rdu", "6rdw", "6rdx", "6rdz", "6re0", "6re2", "6re3", "6re5", "6re6", "6re8", "6re9", "6reb", "6rec", "6ree"...

37

[ "PUB00154471" ]

[ "31221832" ]

[ "Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F1-Fo coupling." ]

[ 2019 ]

1

[]

0

null

[ "CS clade" ]

[ 21 ]

1

[]

0

true

Family

F1F0 ATP synthase subunit ASA5

ASA5

2

IPR054539

54,539

Pyrroloquinoline quinone-dependent pyranose dehydrogenase, beta-propeller domain

Beta-prop_PDH

Domain

10,786

false

This entry includes homologues of the AA12 (Auxilliary activities family 12) enzyme from Trichoderma reesei (TrAA12, , ) [ ], and pyrroloquinoline quinone-dependent pyranose dehydrogenases. TrAA12 is a monodomain protein that adopts six-bladed β-propeller structure. AA12 shows similarities to the global active-site arc...

[]

0

[ "PFAM" ]

[ "PF22807" ]

[ "TrAA12" ]

[ 10786 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.1.99.-", "PWY-2582", "PWY-282", "PWY-5644", "PWY-5748", "PWY-6420", "PWY-6670", "PWY-699", "PWY-7300", "PWY-7599", "PWY-7636", "PWY-8110" ]

[ "EC:1.1.99.-", "METACYC:PWY-2582", "METACYC:PWY-282", "METACYC:PWY-5644", "METACYC:PWY-5748", "METACYC:PWY-6420", "METACYC:PWY-6670", "METACYC:PWY-699", "METACYC:PWY-7300", "METACYC:PWY-7599", "METACYC:PWY-7636", "METACYC:PWY-8110" ]

12

[ "6h7t", "6i1q", "6i1t", "6jt5", "6jwf" ]

5

[ "PUB00154472", "PUB00154973", "PUB00154974", "PUB00154975" ]

[ "31604773", "25121592", "25679509", "27338639" ]

[ "Trichoderma reesei Dehydrogenase, a Pyrroloquinoline Quinone-Dependent Member of Auxiliary Activity Family 12 of the Carbohydrate-Active Enzymes Database: Functional and Structural Characterization.", "Discovery of a eukaryotic pyrroloquinoline quinone-dependent oxidoreductase belonging to a new auxiliary...

[ 2019, 2014, 2015, 2016 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "ecological metagenomes" ]

[ 8355, 2341, 30, 60 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 3 ]

1

true

Domain

Pyrroloquinoline quinone-dependent pyranose dehydrogenase, beta-propeller domain

Beta-prop_PDH

2

IPR054542

54,542

Cys/Met metabolism enzyme, pyridoxal-phosphate attachment site

Cys_met_metab_PP

Conserved_site

58,487

false

This entry represents a conserved site which contains a lysine residue located in the central section of these enzymes to which the pyridoxal-P group is attached. The sequence around this residue is highly conserved. A number of pyridoxal-dependent enzymes involved in the metabolism of cysteine, homocysteine and methio...

[]

0

[ "PROSITE" ]

[ "PS00868" ]

[ "CYS_MET_METAB_PP" ]

[ 58487 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-1614558", "R-CEL-1614603", "R-HSA-1614558", "R-HSA-1614603", "R-HSA-2408508", "R-MMU-1614558", "R-MMU-1614603", "R-MTU-937250", "R-RNO-1614558", "R-RNO-1614603", "R-SCE-1614558", "R-SCE-1614603", "R-SPO-1614558", "R-SPO-1614603" ]

[ "REACTOME:R-CEL-1614558", "REACTOME:R-CEL-1614603", "REACTOME:R-HSA-1614558", "REACTOME:R-HSA-1614603", "REACTOME:R-HSA-2408508", "REACTOME:R-MMU-1614558", "REACTOME:R-MMU-1614603", "REACTOME:R-MTU-937250", "REACTOME:R-RNO-1614558", "REACTOME:R-RNO-1614603", "REACTOME:R-SCE-1614558", "REACTOME...

14

[ "1cl1", "1cl2", "1cs1", "1gc0", "1gc2", "1i41", "1i43", "1i48", "1ibj", "1n8p", "1pg8", "1qgn", "1ukj", "2fq6", "2gqn", "2nmp", "2o7c", "3cog", "3e6g", "3elp", "3qhx", "3qi6", "3vk2", "3vk3", "3vk4", "4itg", "4itx", "4ixs", "4ixz", "4iy7", "4iyo", "4kam"...

110

[ "PUB00002177", "PUB00005650", "PUB00006322", "PUB00035504", "PUB00035505", "PUB00035506", "PUB00035507", "PUB00035508", "PUB00082323" ]

[ "1577698", "8511966", "7748903", "15581583", "8690703", "15189147", "17109392", "16763894", "26662839" ]

[ "Cloning and characterization of the CYS3 (CYI1) gene of Saccharomyces cerevisiae.", "Physical localization of yeast CYS3, a gene whose product resembles the rat gamma-cystathionase and Escherichia coli cystathionine gamma-synthase enzymes.", "Pyridoxal phosphate-dependent enzymes.", "Reaction specificity in ...

[ 1992, 1993, 1995, 2005, 1995, 2004, 2006, 2006, 2016 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 677, 46290, 10944, 576 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae ...

[ 22, 3, 10, 2, 1, 1, 3, 21, 5, 6, 4, 28 ]

12

true

Conserved_site

Cys/Met metabolism enzyme, pyridoxal-phosphate attachment site

Cys_met_metab_PP

4

IPR054543

54,543

Epi-isozizaene synthase

IsozizSyn

Family

272

false

This entry represents Epi-isozizaene synthase and related sequences. It catalyses the cyclization of farnesyl diphosphate (FPP) to the sesquiterpene epi-isozizaene [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045483" ]

[ "IsozizSyn" ]

[ 272 ]

1

[]

0

[ "3kb9", "3kbk", "3lg5", "3lgk", "4ltv", "4ltz", "4luu", "4lxw", "4lz0", "4lz3", "4lzc", "6ax9", "6axm", "6axn", "6axo", "6axu", "6ofv", "7kj8", "7kj9", "7kjd", "7kje", "7kjf", "7kjg", "8su0", "8su1", "8su2", "8su3", "8su4", "8su5", "8v3k" ]

30

[ "PUB00153499" ]

[ "16669656" ]

[ "Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase." ]

[ 2006 ]

1

[ "IPR034686" ]

[]

1

0

1

[ "Actinomycetes" ]

[ 272 ]

1

[]

0

true

Family

Epi-isozizaene synthase

IsozizSyn

5

IPR054544

54,544

Pesticidal crystal protein Cry1Aa, domain IV

Pest_crys_Cry1Aa_dom-IV

Domain

990

false

This entry represents a domain found in the protoxin portion of insecticidal proteins (parasporins, or Cry proteins) such as Cry1Aa from Bacillus thuringiensis (Bt) and related proteins. These proteins contain a proteolytically labile protoxin segment (in the C-terminal region) and a three-domain toxic core at the N-te...

[]

0

[ "PFAM" ]

[ "PF18449" ]

[ "Endotoxin_C2" ]

[ 990 ]

1

[]

0

[ "8w7n", "9h99" ]

2

[ "PUB00091639", "PUB00154565" ]

[ "25139047", "37922785" ]

[ "Structure of the full-length insecticidal protein Cry1Ac reveals intriguing details of toxin packaging into in vivo formed crystals.", "Crystal structure of the in-cell Cry1Aa purified from Bacillus thuringiensis." ]

[ 2014, 2023 ]

2

[]

0

null

[ "Bacillati", "bioreactor metagenome" ]

[ 989, 1 ]

2

[]

0

true

Domain

Pesticidal crystal protein Cry1Aa, domain IV

Pest_crys_Cry1Aa_dom-IV

8

IPR054545

54,545

ApeI dehydratase-like

ApeI-like

Domain

5,312

false

This entry represents a domain found in ApeI dehydratase ( ) and its homologues. This enzyme forms a heterodimer with ApeP that carries out dehydratation in APE biosynthesis. Both subunits in this complex adopt a typical hotdog fold comprising six antiparallel β-strands and a central α-helix [ ]. The domain represented...

[]

0

[ "PFAM" ]

[ "PF22818" ]

[ "ApeI-like" ]

[ 5312 ]

1

[]

0

[ "3esi", "6qsr" ]

2

[ "PUB00153819" ]

[ "30908039" ]

[ "An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halorubrum tibetense", "metagenomes" ]

[ 5258, 10, 1, 43 ]

4

[]

0

true

Domain

ApeI dehydratase-like

ApeI-like

5

IPR054547

54,547

NACHT N-terminal Helical domain 1

NNH1

Domain

1,297

false

This entry represents an α-helical domain found at the N-terminualof bacterial NACHT conflict systems [ ]. This position is frequently occupied by an effector domain.

[]

0

[ "PFAM" ]

[ "PF22733" ]

[ "NNH1" ]

[ 1297 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 1296, 1 ]

2

[]

0

true

Domain

NACHT N-terminal Helical domain 1

NNH1

5

IPR054548

54,548

SCP160-like, KH domain

SCP160-like_KH

Domain

1,289

false

This entry represents a KH domain found in SCP160 from S.cerevisiae and similar fungal sequences. SCP160 is involved in the control of mitotic chromosome transmission. It is required during cell division for faithful partitioning of the ER-nuclear envelope membranes which, in S.cerevisiae, enclose the duplicated chromo...

[]

0

[ "PFAM" ]

[ "PF22952" ]

[ "KH_11" ]

[ 1289 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1289 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

SCP160-like, KH domain

SCP160-like_KH

4

IPR054549

54,549

Protein root UVB sensitive/RUS domain

UVB_sens_RUS_dom

Domain

8,201

false

This domain is found in a group of root UVB sensitive plant proteins and their eukaryotic RUS homologues. In plants, this domain plays a role in auxin-transport, plant growth and development [ , ] and appears to be expressed by all cells in the plant as well as in plastids. This group of proteins has been shown to play...

[]

0

[ "PFAM" ]

[ "PF04884" ]

[ "UVB_sens_prot" ]

[ 8201 ]

1

[]

0

[]

0

[ "PUB00057512", "PUB00057513", "PUB00066759" ]

[ "19515790", "20562234", "21511809" ]

[ "ROOT UV-B SENSITIVE2 acts with ROOT UV-B SENSITIVE1 in a root ultraviolet B-sensing pathway.", "Arabidopsis ROOT UVB SENSITIVE2/WEAK AUXIN RESPONSE1 is required for polar auxin transport.", "root uv-b sensitive mutants are suppressed by specific mutations in ASPARTATE AMINOTRANSFERASE2 and by exogenous vitamin...

[ 2009, 2010, 2011 ]

3

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 8198, 3 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 28, 9, 2, 9, 4, 1, 20, 5, 58 ]

9

true

Domain

Protein root UVB sensitive/RUS domain

UVB_sens_RUS_dom

1

IPR054550

54,550

Mal s 1 allergenic protein-like

Mala_s_1-like

Family

805

false

This family includes the allergenic protein Mala s 1 from the yeast Malassezia sympodialis. Mala s 1 is localised in the cell wall and exposed on the cell surface, where it can trigger specific IgE and T-cell responses in individuals with atopic eczema (AE), a chronic inflammatory skin disease. Although it does not sho...

[]

0

[ "PFAM", "CDD" ]

[ "PF22701", "cd12811" ]

[ "Mala_s_1-like", "MALA" ]

[ 597, 606 ]

2

[]

0

[ "2p9w", "3no2" ]

2

[ "PUB00017010", "PUB00017037", "PUB00027581", "PUB00029179", "PUB00036620", "PUB00042353" ]

[ "11373616", "14561773", "12459547", "12931195", "11435114", "17481656" ]

[ "Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.", "Model of the brain tumor-Pumilio translation repressor complex.", "Structure of the LDL receptor extracellular domain at endosomal pH.", "Complex between nidogen and laminin fragments reveals a para...

[ 2001, 2003, 2002, 2003, 2001, 2007 ]

6

[]

0

null

[ "Eukaryota", "Pseudomonadati", "ecological metagenomes" ]

[ 647, 156, 2 ]

3

[ "Zea mays" ]

[ 5 ]

1

true

Family

Mal s 1 allergenic protein-like

Mala_s_1-like

2

IPR054551

54,551

RSC4, Ig-like domain

RSC4_Ig-like

Domain

1,016

false

The RSC4 family includes components of the RSC chromatin remodeling complex, which plays a crucial role in the regulation of transcription and the positioning of nucleosomes. Members of the RSC4 family are particularly important for the control of genes associated with membrane and organelle development, thereby influe...

[]

0

[ "PFAM", "PFAM" ]

[ "PF22994", "PF24189" ]

[ "RSC4_Ig_like", "Ig_RSC4" ]

[ 950, 66 ]

2

[ "REACTOME" ]

[ "R-SPO-3214858" ]

[ "REACTOME:R-SPO-3214858" ]

1

[ "6k15", "6kw3", "6kw4", "6kw5", "6tda", "6v8o", "6v92" ]

7

[ "PUB00155674", "PUB00155675" ]

[ "15014446", "32188943" ]

[ "Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14.", "Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome." ]

[ 2004, 2020 ]

2

[]

0

null

[ "Fungi" ]

[ 1016 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

RSC4, Ig-like domain

RSC4_Ig-like

7

IPR054552

54,552

SPT2 homolog, N-terminal

SPT2_N

Domain

1,328

false

This entry represents an N-terminal conserved region found in the SPT2 homologues from animals. SPT2 is a histone chaperone that stabilises pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin [ ].

[]

0

[ "PFAM" ]

[ "PF22878" ]

[ "SPT2_N" ]

[ 1328 ]

1

[]

0

[]

0

[ "PUB00154243" ]

[ "26109053" ]

[ "Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2." ]

[ 2015 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 1328 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 2, 1, 3 ]

5

true

Domain

SPT2 homolog, N-terminal

SPT2_N

2

IPR054553

54,553

VirG, insertion domain

VID

Domain

75

false

Outer membrane autotransporter VirG/IcsA is a virulence factor from Shigella flexneri that acts as an adhesin and actin-polymerising factor during infection [ ]. It mediates polar adhesion to host cells and their invasion. The bile salt deoxycholate activates adhesion and invasion of host cells, possibly by altering Ic...

[]

0

[ "PFAM" ]

[ "PF22364" ]

[ "VID" ]

[ 75 ]

1

[]

0

[ "5ke1" ]

1

[ "PUB00106899", "PUB00154597" ]

[ "28268178", "24721572" ]

[ "Structural insights into the architecture of the Shigella flexneri virulence factor IcsA/VirG and motifs involved in polar distribution and secretion.", "IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesis." ]

[ 2017, 2014 ]

2

[]

0

null

[ "Escherichia phage phi456", "Panagrolaimus superbus", "Pseudomonadota" ]

[ 1, 1, 73 ]

3

[]

0

true

Domain

VirG, insertion domain

VID

8

IPR054554

54,554

Zona pellucida sperm-binding protein 1/4, Ig-like domain

ZP1/4_Ig-like

Domain

1,378

false

This entry represents an immunoglobulin-like domain found at the N-terminal of Zona pellucida sperm-binding proteins 1 and 4 (ZP1 and ZP4) [ ]. ZP1 and ZP4 are components of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post...

[]

0

[ "PFAM" ]

[ "PF22821" ]

[ "ZP1_ZP4_Ig-like" ]

[ 1378 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2534343", "R-HSA-2534343", "R-MMU-2534343", "R-SSC-2534343" ]

[ "REACTOME:R-BTA-2534343", "REACTOME:R-HSA-2534343", "REACTOME:R-MMU-2534343", "REACTOME:R-SSC-2534343" ]

4

[ "6gf6", "6gf7", "6gf8" ]

3

[ "PUB00154341", "PUB00154342", "PUB00160749" ]

[ "31300655", "34440440", "39753129" ]

[ "Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility.", "Zona Pellucida Genes and Proteins: Essential Players in Mammalian Oogenesis and Fertility.", "CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans." ]

[ 2019, 2021, 2025 ]

3

[]

0

null

[ "Gnathostomata" ]

[ 1378 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 20, 4, 3, 10 ]

4

true

Domain

Zona pellucida sperm-binding protein 1/4, Ig-like domain

ZP1/4_Ig-like

7

IPR054555

54,555

Type III secretion system effector HopBF1-like

T3SS_HopBF1-like

Domain

236

false

This entry includes HopBF1 family of bacterial type III secretion system (T3SS) effectors identified as eukaryotic-specific HSP90 protein kinases. HopBF1 ( ) adopts a minimal and atypical protein kinase fold such that it is recognized by HSP90 as a host client. Utilizing this "betrayal-like" mechanism to achieve specif...

[]

0

[ "PFAM", "CDD" ]

[ "PF26324", "cd20900" ]

[ "HopBF1_kinase", "HopBF1" ]

[ 143, 229 ]

2

[]

0

[ "6pwd", "6pwg", "8hoe" ]

3

[ "PUB00105465" ]

[ "31522888" ]

[ "A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 233, 3 ]

2

[]

0

true

Domain

Type III secretion system effector HopBF1-like

T3SS_HopBF1-like

7

IPR054556

54,556

T3SS, low calcium response E, C-terminal helical domain

T3SS_CopN_C

Domain

50

false

This domain is found at the C-terminal of Low calcium response E from Chlamydia pneumoniae (CopN, also known as LcrE, ) and similar bacterial sequences. CopN is involved in the regulation of type III secretion systems (T3SSs). This protein contains three repetitions of a helical motif flanked by disordered N- and C-ter...

[]

0

[ "PFAM" ]

[ "PF22342" ]

[ "T3SS_CopN_3rd" ]

[ 50 ]

1

[]

0

[ "4nrh", "4p3z", "4p40", "6gx7" ]

4

[ "PUB00106892", "PUB00154250", "PUB00154251" ]

[ "25056950", "25375170", "31036638" ]

[ "Biochemical and structural insights into microtubule perturbation by CopN from Chlamydia pneumoniae.", "A gatekeeper chaperone complex directs translocator secretion during type three secretion.", "Insight into microtubule nucleation from tubulin-capping proteins." ]

[ 2014, 2014, 2019 ]

3

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 49, 1 ]

2

[]

0

true

Domain

T3SS, low calcium response E, C-terminal helical domain

T3SS_CopN_C

7

IPR054557

54,557

NACHT-associated inactive Restriction Endonuclease 1 sensor domain

NA-iREase1_dom

Domain

348

false

This entry represents a predicted sensor domain in bacterial NACHT conflict systems. It is likely to bind a ligand which could contribute to activation of enzymatic domains additionally fused to the N-terminal of the NACHT module [ ].

[]

0

[ "PFAM" ]

[ "PF22722" ]

[ "NA-iREase1" ]

[ 348 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Potamilus streckersoni", "Stenosarchaea group", "metagenomes" ]

[ 327, 3, 1, 4, 13 ]

5

[]

0

true

Domain

NACHT-associated inactive Restriction Endonuclease 1 sensor domain

NA-iREase1_dom

1

IPR054559

54,559

PSMD12/CSN4-like, N-terminal

PSMD12-CSN4-like_N

Domain

10,438

false

The 26S proteasome consists of a 20S proteolytic core particle (CP) and a 19S regulatory particle (RP). The RP can be further divided into two subcomplexes, a base and a peripheral lid. The RP lid is structurally similar to the COP9 signalosome (CSN). The core CSN subunits (CSN4/5/7/6) show a remarkable one-to-one sequ...

[]

0

[ "PFAM" ]

[ "PF22241" ]

[ "PSMD12-CSN4_N" ]

[ 10438 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1236978", "R-BTA-174084", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA-2467813", "R-BTA-2871837", "R-BTA-349425", "R-BTA-350562", "R-BTA-382556", "R-BTA-450408", "R-BTA-4608870", "R-B...

[ "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-174084", "REACTOME:R-BTA-174154", "REACTOME:R-BTA-174178", "REACTOME:R-BTA-174184", "REACTOME:R-BTA-187577", "REACTOME:R-BTA-195253", "REACTOME:R-BTA-202424", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA...

256

[ "3jck", "3jco", "3jcp", "4cr2", "4cr3", "4cr4", "4d0p", "4d10", "4d18", "4wsn", "5a5b", "5gjq", "5gjr", "5l4k", "5ln3", "5m32", "5mpb", "5mpc", "5mpd", "5mpe", "5t0c", "5t0g", "5t0h", "5t0i", "5t0j", "5vfp", "5vfq", "5vfr", "5vfs", "5vft", "5vfu", "5vgz"...

124

[ "PUB00033528", "PUB00091374", "PUB00110070", "PUB00152659", "PUB00154186" ]

[ "11742986", "25043011", "27428775", "26744777", "30177392" ]

[ "Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome.", "Crystal structure of the human COP9 signalosome.", "An atomic structure of the human 26S proteasome.", "Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.", "S...

[ 2001, 2014, 2016, 2016, 2018 ]

5

[]

0

null

[ "Eukaryota" ]

[ 10438 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 2, 4, 3, 10, 11, 2, 7, 15, 1, 2, 30 ]

12

true

Domain

PSMD12/CSN4-like, N-terminal

PSMD12-CSN4-like_N

6

IPR054560

54,560

Metapyrocatechase-like, N-terminal domain

XylE-like_N

Domain

1,568

false

This entry represents the N-terminal domain of a group of bacterial proteins that function as 2,3-dioxigenases, including Metapyrocatechase from Pseudomonas putida (XylE), which catalyses the incorporation of dioxygen into catechol and the extradiol ring cleavage to form 2-hydroxymuconate semialdehyde [ , , , , ].

[]

0

[ "PFAM" ]

[ "PF22247" ]

[ "Diox-like_N" ]

[ 1568 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.13.11.2", "PWY-5419", "PWY-5641" ]

[ "EC:1.13.11.2", "METACYC:PWY-5419", "METACYC:PWY-5641" ]

3

[ "1mpy", "3hpv", "3hpy", "3hq0", "5znh", "5zsx", "5zsz" ]

7

[ "PUB00022487", "PUB00027414", "PUB00051656", "PUB00064041", "PUB00121681" ]

[ "15028678", "10368270", "18826259", "23066739", "19828456" ]

[ "Crystallographic comparison of manganese- and iron-dependent homoprotocatechuate 2,3-dioxygenases.", "An archetypical extradiol-cleaving catecholic dioxygenase: the crystal structure of catechol 2,3-dioxygenase (metapyrocatechase) from Ppseudomonas putida mt-2.", "Intermediate in the O-O bond cleavage reaction...

[ 2004, 1999, 2008, 2012, 2009 ]

5

[ "IPR037523" ]

[]

1

0

1

[ "Bacteria", "Cyprideis torosa", "Halobacteriales", "Sym plasmid", "unclassified sequences" ]

[ 1513, 1, 34, 1, 19 ]

5

[]

0

true

Domain

Metapyrocatechase-like, N-terminal domain

XylE-like_N

5

IPR054563

54,563

Hyaluronate lyase-like, N-terminal

HylB-like_N

Domain

364

false

This entry represents the N-terminal domain of hyaluronate lyases (HylB) mainly found in Lactobacillales. These enzymes degrade hyaluronan and certain chondroitin sulfates at beta-1,4 glycosidic linkages and constitutes a virulence factor in Streptococcus agalactiae [ ]. This domain is also found in accessory protein B...

[]

0

[ "PFAM" ]

[ "PF22637" ]

[ "CBM_4_9_1" ]

[ 364 ]

1

[]

0

[ "4d0q", "5e7t" ]

2

[ "PUB00008088", "PUB00021705", "PUB00024748", "PUB00028799", "PUB00050313", "PUB00061245", "PUB00151805" ]

[ "8916925", "12079353", "11527972", "11980475", "18025086", "22434778", "26814179" ]

[ "Structure of the N-terminal cellulose-binding domain of Cellulomonas fimi CenC determined by nuclear magnetic resonance spectroscopy.", "Differential oligosaccharide recognition by evolutionarily-related beta-1,4 and beta-1,3 glucan-binding modules.", "Hyaluronan binding and degradation by Streptococcus agalac...

[ 1996, 2002, 2001, 2002, 2008, 2012, 2016 ]

7

[]

0

null

[ "Bacteria", "Caudoviricetes" ]

[ 347, 17 ]

2

[]

0

true

Domain

Hyaluronate lyase-like, N-terminal

HylB-like_N

9

IPR054564

54,564

Tail sheath protein Gp18-like, domain III N-terminal region

Gp18_domIII_N

Domain

4,187

false

This entry represents the N-terminal segment of domain III from the phage tail sheath protein Gp18 y similar sequences [ , , , , ]. Domain III is completed by with an overall structure consisting of a β-sheet with five parallel and one anti-parallel β-strands plus six α-helices, which surround the β-sheet.

[]

0

[ "PFAM" ]

[ "PF22671" ]

[ "Gp18_domIII_N" ]

[ 4187 ]

1

[]

0

[ "3foa", "3foh", "3foi", "3hxl", "3j2m", "3j2n", "3j9q", "3j9r", "3lml", "6pyt", "6u5b", "6u5f", "6u5j", "6u5k", "9ev2", "9f4a" ]

16

[ "PUB00052010", "PUB00065095", "PUB00097484", "PUB00145048", "PUB00153987" ]

[ "19229296", "23434847", "30905475", "30127773", "25822993" ]

[ "The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria.", "The Molecular Architecture of the Bacteriophage T4 Neck.", "Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System.", "Crystal Structures of R-Type Bacteriocin Sheath and Tube Proteins CD136...

[ 2009, 2013, 2019, 2018, 2015 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2, 3643, 23, 503, 16 ]

5

[]

0

true

Domain

Tail sheath protein Gp18-like, domain III N-terminal region

Gp18_domIII_N

4

IPR054567

54,567

NACHT N-terminal Helical domain 7

NNH7

Domain

694

false

This entry represents an helical domain found at the N-terminal of bacterial NACHT conflict systems. This position is frequently occupied by an effector domain [ ].

[]

0

[ "PFAM" ]

[ "PF22738" ]

[ "NNH7" ]

[ 694 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Methanosarcina vacuolata Z-761" ]

[ 693, 1 ]

2

[]

0

true

Domain

NACHT N-terminal Helical domain 7

NNH7

1

IPR054568

54,568

NACHT N-terminal Helical domain 3

NNH3

Domain

272

false

This is an helical domain found at the N-terminal of bacterial NACHT conflict systems [ ]. This position is frequently occupied by an effector domain.

[]

0

[ "PFAM" ]

[ "PF22735" ]

[ "NNH3" ]

[ 272 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 270, 2 ]

2

[]

0

true

Domain

NACHT N-terminal Helical domain 3

NNH3

3

IPR054569

54,569

NACHT N-terminal Helical domain 2

NNH2

Domain

213

false

This is an helical domain found at the N-terminal of bacterial NACHT conflict systems [ ]. This position is frequently occupied by an effector domain.

[]

0

[ "PFAM" ]

[ "PF22734" ]

[ "NNH2" ]

[ 213 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria" ]

[ 213 ]

1

[]

0

true

Domain

NACHT N-terminal Helical domain 2

NNH2

3

IPR054570

54,570

NACHT, C-terminal Cysteine and Histidine-containing domain

NCC-H_dom

Domain

287

false

This is a domain discovered C-terminal to HEAT repeat modules, observed in some bacterial NACHT conflict systems. These domains feature highly conserved cysteine and histidine residues [ ].

[]

0

[ "PFAM" ]

[ "PF22730" ]

[ "NCC-H" ]

[ 287 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Cyanophyceae" ]

[ 287 ]

1

[]

0

true

Domain

NACHT, C-terminal Cysteine and Histidine-containing domain

NCC-H_dom

8

IPR054572

54,572

TATA-binding-like protein domain of the TOTE conflict systems

TBP-TOTE

Domain

220

false

This entry represents the principal predicted hybrid duplex-binding domain of the TOTE (TPR, OB, TBP, Effector) conflict systems described as TATA-binding-like protein (TBP) domain of the TOTE (TBP-TOTE) in [ ].

[]

0

[ "PFAM" ]

[ "PF22721" ]

[ "TBP-TOTE" ]

[ 220 ]

1

[]

0

[]

0

[ "PUB00153788" ]

[ "35609893" ]

[ "Discovering Biological Conflict Systems Through Genome Analysis: Evolutionary Principles and Biochemical Novelty." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Neophaeococcomyces mojaviensis", "metagenomes" ]

[ 212, 1, 7 ]

3

[]

0

true

Domain

TATA-binding-like protein domain of the TOTE conflict systems

TBP-TOTE

3

IPR054573

54,573

Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat

PP2A/SF3B1-like_HEAT

Domain

11,540

false

This entry represents HEAT repeats found in serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A (PP2ARA) and Splicing factor 3B subunit 1 [ , , , , ]. PP2AR serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. It is required for proper...

[]

0

[ "PFAM" ]

[ "PF22646" ]

[ "PPP2R1A-like_HEAT" ]

[ 11540 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-195253", "R-CEL-196299", "R-CEL-198753", "R-CEL-202670", "R-CEL-2995383", "R-CEL-389513", "R-CEL-5673000", "R-CEL-5675221", "R-CEL-6811558", "R-CEL-69231", "R-CEL-69273", "R-CEL-975957", "R-CEL-9833482", "R-CEL-9860927", "R-DDI-113501", "R-DDI-198753", "R-DDI-202670", "R-DDI...

[ "REACTOME:R-CEL-195253", "REACTOME:R-CEL-196299", "REACTOME:R-CEL-198753", "REACTOME:R-CEL-202670", "REACTOME:R-CEL-2995383", "REACTOME:R-CEL-389513", "REACTOME:R-CEL-5673000", "REACTOME:R-CEL-5675221", "REACTOME:R-CEL-6811558", "REACTOME:R-CEL-69231", "REACTOME:R-CEL-69273", "REACTOME:R-CEL-9...

201

[ "1b3u", "2iae", "2ie3", "2ie4", "2npp", "2nyl", "2nym", "2pf4", "2pkg", "3dw8", "3fga", "3k7v", "3k7w", "4i5l", "4i5n", "5gm6", "5ife", "5lqw", "5nrl", "5o9z", "5w0w", "5z56", "5z57", "5z58", "5zwm", "5zwo", "5zya", "6ah0", "6ahd", "6ef4", "6en4", "6ff4"...

113

[ "PUB00006180", "PUB00030197", "PUB00035461", "PUB00036086", "PUB00041276", "PUB00041649", "PUB00074475", "PUB00088342" ]

[ "9989501", "10353245", "16432215", "17055435", "16901787", "17086192", "16580887", "11500380" ]

[ "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.", "Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.", "Crystal structure of a core spliceosomal protein interface.", "Structure of protein phosphatase 2A core...

[ 1999, 1999, 2006, 2006, 2006, 2007, 2006, 2001 ]

8

[]

0

null

[ "Eukaryota" ]

[ 11540 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 17, 3, 5, 6, 18, 14, 2, 14, 16, 2, 2, 41 ]

12

true

Domain

Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat

PP2A/SF3B1-like_HEAT

1

IPR054574

54,574

Cgl0159-like domain

Cgl0159_dom

Domain

2,488

false

This domain is found in the uncharacterised protein Cgl0159 from Corynebacterium glutamicum ( ) and its homologues mainly from actinomycetes. It adopts a classical (β/α)8 barrel. Members of this entry share significant similarity with Deoxyribose-phosphate aldolase.

[]

0

[ "PFAM" ]

[ "PF22649" ]

[ "Cgl0159" ]

[ 2488 ]

1

[]

0

[ "3fok" ]

1

[ "PUB00029475", "PUB00038045", "PUB00049025", "PUB00052973", "PUB00060484" ]

[ "12941964", "15766250", "17713928", "19714241", "20427286" ]

[ "Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins.", "Mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase: structural analysis of reaction intermediates.", "Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst i...

[ 2003, 2005, 2007, 2009, 2010 ]

5

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 2, 2447, 39 ]

3

[]

0

true

Domain

Cgl0159-like domain

Cgl0159_dom

3

IPR054575

54,575

Glyoxalase At5g48480-like, C-terminal

At5g48480-like_C

Domain

571

false

This entry includes plant sequences that belong to the Lactoylglutathione lyase/glyoxalase I family. They are poorly characterised and contain two characteristic VOC domains. Members of this entry contain conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping. This en...

[]

0

[ "PFAM" ]

[ "PF22650" ]

[ "At5g48480-like_C" ]

[ 571 ]

1

[]

0

[ "1xy7", "2q48" ]

2

[]

0

[]

0

null

[ "Bacteria", "Embryophyta" ]

[ 3, 568 ]

2

[ "Arabidopsis thaliana" ]

[ 3 ]

1

true

Domain

Glyoxalase At5g48480-like, C-terminal

At5g48480-like_C

9

IPR054576

54,576

Glyoxalase At5g48480-like, N-terminal

At5g48480-like_N

Domain

687

false

This entry includes, mainly, plant sequences that belong to the Lactoylglutathione lyase/glyoxalase I family. They are poorly characterised and contain two characteristic VOC domains. Members of this entry contain conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping...

[]

0

[ "PFAM" ]

[ "PF22656" ]

[ "At5g48480-like_N" ]

[ 687 ]

1

[]

0

[ "1xy7", "2q48" ]

2

[]

0

[]

0

null

[ "Bacteria", "Candidatus Nitrosotenuis uzonensis", "Embryophyta" ]

[ 2, 1, 684 ]

3

[ "Arabidopsis thaliana" ]

[ 3 ]

1

true

Domain

Glyoxalase At5g48480-like, N-terminal

At5g48480-like_N

7

IPR054577

54,577

OBP47-like domain

OBP47-like_dom

Domain

689

false

This domain is found in the Anopheles gambiae odorant-binding protein AgamOBP47 ( ) and related insect proteins. OBP47 belongs a C-plus class OBP and possesses 13 cysteine residues. It folds into a eight helical structure instead of six as observed in the classical OBPs and no internal cavity [ ].

[]

0

[ "PFAM" ]

[ "PF22651" ]

[ "OBP47_like" ]

[ 689 ]

1

[]

0

[ "3pm2", "4ij7", "4kyn" ]

3

[ "PUB00154133", "PUB00154134" ]

[ "21561433", "24097978" ]

[ "Crystal structure of a novel type of odorant-binding protein from Anopheles gambiae, belonging to the C-plus class.", "Crystal and solution studies of the \"Plus-C\" odorant-binding protein 48 from Anopheles gambiae: control of binding specificity through three-dimensional domain swapping." ]

[ 2011, 2013 ]

2

[]

0

null

[ "Pterygota" ]

[ 689 ]

1

[ "Drosophila melanogaster" ]

[ 12 ]

1

true

Domain

OBP47-like domain

OBP47-like_dom

4

IPR054578

54,578

SpoU L30e-like, N-terminal

SpoU_sub_bind-like_N

Domain

773

false

This domain is found in a group of rRNA methyltransferases that belong to SpoU family, including 23S rRNA (uridine(2479)-2'-O)-methyltransferase from Streptomyces viridochromogenes. They are composed of two domains: N-terminal, represented by this entry, and the RNA-binding domain and C-terminal domain responsible for ...

[]

0

[ "PFAM" ]

[ "PF22655" ]

[ "SpoU_sub_bind_like" ]

[ 773 ]

1

[]

0

[ "1x7o", "1x7p" ]

2

[ "PUB00032343" ]

[ "15581897" ]

[ "Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 770, 3 ]

2

[]

0

true

Domain

SpoU L30e-like, N-terminal

SpoU_sub_bind-like_N

4

IPR054579

54,579

4-O-methyl-glucuronoyl methylesterase-like domain

GCE-like_dom

Domain

3,407

false

This entry represents a domain found in 4-O-methyl-glucuronoyl methylesterase from Schizophyllum commune (GCE) and similar glucuronyl esterases from fungi and bacteria. This protein seems to play a significant role in biomass degradation, as they can disconnect hemicellulose from lignin through the hydrolysis of the es...

[]

0

[ "PFAM" ]

[ "PF22244" ]

[ "GCE_fung" ]

[ 3407 ]

1

[ "EC" ]

[ "3.1.1.117" ]

[ "EC:3.1.1.117" ]

1

[ "3pic", "4g4g", "4g4i", "4g4j", "6ehn", "6grw", "6gry", "6gs0", "6gu8", "6hsw", "6rtv", "6ru1", "6ru2", "6rv7", "6rv8", "6rv9", "6syr", "6syu", "6syv", "6sz0", "6sz4", "6szo", "6t0e", "6t0i", "7b7h", "7nn3", "8b48", "8q6s", "8qcl", "8qef", "8tru", "8trx"...

33

[ "PUB00065495", "PUB00153963", "PUB00153964", "PUB00153965", "PUB00154599" ]

[ "21661060", "23275164", "29222424", "30083226", "16876163" ]

[ "Structure of the catalytic domain of glucuronoyl esterase Cip2 from Hypocrea jecorina.", "The structure of a novel glucuronoyl esterase from Myceliophthora thermophila gives new insights into its role as a potential biocatalyst.", "Structural insight into a CE15 esterase from the marine bacterial metagenome.",...

[ 2011, 2013, 2017, 2018, 2006 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 2132, 1205, 12, 58 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

4-O-methyl-glucuronoyl methylesterase-like domain

GCE-like_dom

7

IPR054580

54,580

Nucleoid occlusion factor SlmA-like, C-terminal

SlmA-like_C

Domain

3,691

false

This domain is found at the C-terminal end of Nucleoid occlusion factor SlmA from Escherichia coli and similar transcriptional repressors from proteobacteria. SlmA is required for the nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. It is organised into two domain...

[]

0

[ "PFAM" ]

[ "PF22276" ]

[ "SlmA-like_C" ]

[ 3691 ]

1

[]

0

[ "3nxc", "4gck", "4gcl", "4gct", "4gfk", "4gfl", "5haw", "5hbu", "5hsz", "5k58" ]

10

[ "PUB00065191", "PUB00091666", "PUB00154235", "PUB00154236" ]

[ "23408580", "27091999", "21113127", "23754405" ]

[ "Structure and function of a TetR family transcriptional regulator, SbtR, from Thermus thermophilus HB8.", "Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ.", "Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytoki...

[ 2013, 2016, 2011, 2013 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "metagenomes" ]

[ 2, 3646, 2, 41 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Nucleoid occlusion factor SlmA-like, C-terminal

SlmA-like_C

4

IPR054581

54,581

Encapsulated ferritin-like

EncFtn-like

Family

1,225

false

This protein family includes Encapsulated ferritin-like protein from Rhodospirillum rubrum (EncFtn) and similar prokaryotic sequences. This encapsulated ferritin that acts as a ferroxidase adopts an open decameric structure. Each monomer has an N-terminal 3-10-helix, two long antiparallel α-helices and a shorter helix ...

[]

0

[ "PFAM" ]

[ "PF22277" ]

[ "EncFtn-like" ]

[ 1225 ]

1

[]

0

[ "3k6c", "5da5", "5l89", "5l8b", "5l8f", "5l8g", "5n5f", "6suw", "6sv1", "7oe2", "7oeu", "7s5c", "7s5k", "7s8t" ]

14

[ "PUB00100753", "PUB00100754", "PUB00153926" ]

[ "27529188", "32878987", "30837306" ]

[ "Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments.", "Dissecting the structural and functional roles of a putative metal entry site in encapsulated ferritins.", "Conservation of the structural and functional architecture of encapsulated ferrit...

[ 2016, 2020, 2019 ]

3

[]

[ "IPR030907" ]

0

1

0

[ "Alphatristromavirus", "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2, 74, 1112, 4, 33 ]

5

[]

0

true

Family

Encapsulated ferritin-like

EncFtn-like

3

IPR054582

54,582

Dimethylamine monooxygenase subunit DmmA-like, N-terminal domain

DmmA-like_N

Domain

4,340

false

This entry represents the N-terminal domain of the dimethylamine monooxygenase subunit DmmA from Methylocella silvestris (Msil_3607, ) and similar sequences, mainly found in proteobacteria and actinomycetes. Dimethylamine (DMA) monooxygenase is required for metabolism of trimethylamine N-oxide (TMAO) [ , ]. This domain...

[]

0

[ "PFAM" ]

[ "PF22290" ]

[ "DmmA-like_N" ]

[ 4340 ]

1

[ "EC" ]

[ "1.14.13" ]

[ "EC:1.14.13" ]

1

[ "6kbh", "6laa", "7ylr" ]

3

[ "PUB00088057", "PUB00100877", "PUB00106271", "PUB00106272" ]

[ "25440057", "27851736", "25088783", "28304370" ]

[ "γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO.", "An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.", "Identification and characterization of trimethylamine N-oxide (TMAO) demethylase and TMAO permease in Methylocella silve...

[ 2014, 2016, 2014, 2017 ]

4

[]

0

null

[ "Bacteria", "Natrialbaceae", "Opisthokonta", "metagenomes" ]

[ 4146, 3, 168, 23 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Dimethylamine monooxygenase subunit DmmA-like, N-terminal domain

DmmA-like_N

2

IPR054583

54,583

Aldos-2-ulose dehydratase, beta-propeller domain

Beta-prop_AUDH

Domain

580

false

This domain is found in Aldos-2-ulose dehydratase from Phanerodontia chrysosporium (AUDH) and similar sequences from invertebrates, fungi and bacteria. AUDH is a bifunctional enzyme which catalyses the dehydration of anhydrofructose into ascopyrone M, and the isomerisation of ascopyrone M into microthecin. It is organi...

[]

0

[ "PFAM" ]

[ "PF22301" ]

[ "AUDH_beta_propeller" ]

[ 580 ]

1

[]

0

[ "4a7k", "4a7y", "4a7z" ]

3

[ "PUB00065867" ]

[ "22330145" ]

[ "Crystal structure of bifunctional aldos-2-ulose dehydratase/isomerase from Phanerochaete chrysosporium with the reaction intermediate ascopyrone M." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 270, 307, 3 ]

3

[]

0

true

Domain

Aldos-2-ulose dehydratase, beta-propeller domain

Beta-prop_AUDH

2

IPR054584

54,584

Envelope glycoprotein GP2-like, HR1-HR2

Ebola-like_HR1-HR2

Domain

530

false

This entry spans heptad repeats 1 and 2 of the glycoprotein (GP) from Ebola and Marburg viruses [ , , , , ]. Viral infection involves the formation of a trimer-of-hairpins structure (three HR1s helices, buttressed by three HR2 helices lying in antiparallel orientation). This domain may have been acquired via horizontal...

[]

0

[ "PFAM" ]

[ "PF22307" ]

[ "Ebola-like_HR1-HR2" ]

[ 530 ]

1

[]

0

[ "1ebo", "2ebo", "2lcy", "2lcz", "2m5f", "2mb1", "3csy", "3s88", "3ve0", "4g2k", "4r0r", "5f1b", "5fhc", "5hj3", "5jnx", "5jq3", "5jq7", "5jqb", "5kel", "5ken", "5uqy", "6bp2", "6dzl", "6dzm", "6ea5", "6ea7", "6eay", "6f5u", "6f6i", "6f6n", "6f6s", "6g95"...

74

[ "PUB00028421", "PUB00032802", "PUB00066075", "PUB00126896", "PUB00153919" ]

[ "9844633", "10077567", "21690393", "18615077", "24696482" ]

[ "Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain.", "Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution.", "Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2.", "Structure of...

[ 1998, 1999, 2011, 2008, 2014 ]

5

[]

0

null

[ "Filoviridae" ]

[ 530 ]

1

[]

0

true

Domain

Envelope glycoprotein GP2-like, HR1-HR2

Ebola-like_HR1-HR2

6

IPR054585

54,585

External alternative NADH-ubiquinone oxidoreductase-like, C-terminal domain

NDH2-like_C

Domain

14,483

false

This entry represent the C-terminal domain of alternative NADH:quinone oxidoreductases known as NDH2 and related proteins. NDH2 delivers electrons to the respiratory chain by oxidation of NADH and reduction of quinones but does not pump protons. NDH2 have a particular relevance in yeasts like Saccharomyces cerevisiae a...

[]

0

[ "PFAM" ]

[ "PF22366" ]

[ "NDH2_C" ]

[ 14483 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "1.6.5.9", "PWY-7269", "PWY-7279", "PWY-7998" ]

[ "EC:1.6.5.9", "METACYC:PWY-7269", "METACYC:PWY-7279", "METACYC:PWY-7998" ]

4

[ "4g6g", "4g6h", "4g73", "4g74", "4g9k", "4gap", "4gav", "5jwa", "5jwb", "5jwc", "5yjw", "5yjx", "5yjy" ]

13

[ "PUB00097735", "PUB00097739", "PUB00154098", "PUB00154821", "PUB00154822" ]

[ "15590775", "24709059", "28195463", "12972666", "1735444" ]

[ "New insights into type II NAD(P)H:quinone oxidoreductases.", "Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines.", "Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH...

[ 2004, 2014, 2017, 2003, 1992 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 55, 5893, 8431, 104 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 26, 3, 9, 3, 2, 26 ]

6

true

Domain

External alternative NADH-ubiquinone oxidoreductase-like, C-terminal domain

NDH2-like_C

9

IPR054587

54,587

Complement C4A/B, CUB C-terminal domain

CO4A-B_CUB_C

Domain

786

false

Complement C4 is organised in 12 structural domains, with eight macroglobulin (MG) domains forming the core of the molecule [ , , , ]. They have a thioester domain (TED, ), a large α-helical domain inserted in the CUB (complement C1r/C1s, Uegf, Bmp1) domain [ ] which consists of two antiparallel β-sheets. This entry co...

[]

0

[ "PFAM" ]

[ "PF22661" ]

[ "CO4A-B_CUB_C" ]

[ 786 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-166663", "R-HSA-174577", "R-HSA-381426", "R-HSA-8957275", "R-HSA-977606", "R-MMU-166663", "R-MMU-174577", "R-MMU-381426", "R-MMU-8957275", "R-MMU-977606", "R-RNO-166663", "R-RNO-174577", "R-RNO-381426", "R-RNO-8957275", "R-RNO-977606" ]

[ "REACTOME:R-HSA-166663", "REACTOME:R-HSA-174577", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-HSA-977606", "REACTOME:R-MMU-166663", "REACTOME:R-MMU-174577", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275", "REACTOME:R-MMU-977606", "REACTOME:R-RNO-166663", "REACTOME:R-RNO-1...

15

[ "5jpm", "5jpn", "5jtw", "6ysq", "7b2m", "7b2p", "7b2q" ]

7

[ "PUB00028642", "PUB00062695", "PUB00153876", "PUB00153877", "PUB00153878" ]

[ "12367531", "22949645", "27599733", "25911760", "32769120" ]

[ "X-ray crystal structure of the C4d fragment of human complement component C4.", "Structural basis for activation of the complement system by component C4 cleavage.", "Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.",...

[ 2002, 2012, 2016, 2015, 2020 ]

5

[]

0

null

[ "Gnathostomata" ]

[ 786 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 10, 7 ]

3

true

Domain

Complement C4A/B, CUB C-terminal domain

CO4A-B_CUB_C

3

IPR054588

54,588

Csa3, N-terminal

Csa3_N

Domain

317

false

This domain is found at the N-terminal in CRISPR-associated protein Csa3 and related proteins. Csa3 proteins consist of two domains that intertwine to form a homodimer. The N-terminal domain (also known as CARF domain) is a unique variation on the nucleotide-binding domain, and it is essential for dimer formation. It i...

[]

0

[ "PFAM" ]

[ "PF22662" ]

[ "Csa3_N" ]

[ 317 ]

1

[]

0

[ "2wte", "6w11", "6wxq" ]

3

[ "PUB00055126", "PUB00106905", "PUB00153893" ]

[ "21093452", "35038453", "34944496" ]

[ "The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system.", "Structural basis of cyclic oligoadenylate binding to the transcription factor Csa3 outlines cross talk between type III and type I CRISPR systems.", "Cyclic Tetra-Adenylate (cA4) Rec...

[ 2011, 2022, 2021 ]

3

[]

0

null

[ "Archaea", "Bacteria", "marine sediment metagenome" ]

[ 311, 3, 3 ]

3

[]

0

true

Domain

Csa3, N-terminal

Csa3_N

3

IPR054589

54,589

NACHT C-terminal Helical domain 4

NCH4

Domain

67

false

This is an helical domain found at the C terminus of bacterial NACHT conflict systems [ ].

[]

0

[ "PFAM" ]

[ "PF22731" ]

[ "NCH4" ]

[ 67 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria" ]

[ 67 ]

1

[]

0

true

Domain

NACHT C-terminal Helical domain 4

NCH4

4

IPR054590

54,590

Ephrin receptor 1, SAM domain-like

EPH_SAM

Domain

113

false

This entry represents the SAM-like domain found in the Ephrin receptor 1 from nematodes. The Ephrin receptor 1 family comprises tyrosine kinase receptors that interact with ephrins and major sperm proteins (MSPs). They play a crucial role in various biological processes including the inhibition of oocyte meiotic matura...

[]

0

[ "PFAM" ]

[ "PF22993" ]

[ "SAM_EPH" ]

[ 113 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-2682334", "R-CEL-3928662", "R-CEL-3928663", "R-CEL-3928664", "R-CEL-3928665", "R-CEL-9013149", "R-CEL-9013404", "R-CEL-9013408", "R-CEL-9013420", "R-CEL-9013423", "R-CEL-9013424" ]

[ "REACTOME:R-CEL-2682334", "REACTOME:R-CEL-3928662", "REACTOME:R-CEL-3928663", "REACTOME:R-CEL-3928664", "REACTOME:R-CEL-3928665", "REACTOME:R-CEL-9013149", "REACTOME:R-CEL-9013404", "REACTOME:R-CEL-9013408", "REACTOME:R-CEL-9013420", "REACTOME:R-CEL-9013423", "REACTOME:R-CEL-9013424" ]

11

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 113 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

Ephrin receptor 1, SAM domain-like

EPH_SAM

8