LiteFold/InterPro · Datasets at Hugging Face

IPR054591

54,591

PL28 ulvan lyase

PL28

Domain

88

false

This entry includes sequences from the PL28 family of ulvan lyases. These enzymes degrade ulvan next to either epimer of uronic acid. They adopt a β-sandwich structure with a jelly-roll topology containing a deep positively charged cleft that defines the substrate binding site [ ]. This domain is found as standalone or...

[]

0

[ "PFAM" ]

[ "PF22826" ]

[ "PL28" ]

[ 88 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "4.2.2.-", "PWY-7246", "PWY-7647" ]

[ "EC:4.2.2.-", "METACYC:PWY-7246", "METACYC:PWY-7647" ]

3

[ "6d2c", "6d3u" ]

2

[ "PUB00154170" ]

[ "29875159" ]

[ "Structural and functional characterization of PL28 family ulvan lyase NLR48 from Nonlabens ulvanivorans." ]

[ 2018 ]

1

[]

0

null

[ "Bacteroidota" ]

[ 88 ]

1

[]

0

true

Domain

PL28 ulvan lyase

PL28

8

IPR054592

54,592

Inactive Receiver domain

iREC

Domain

58

false

This entry represents the inactive Receiver domain (iREC). iREC is predicted to dimerize with active counterparts as part of signal transduction relays in a subset of TOTE (TPR, OB, TBP, Effector) biological conflict systems [ ].

[]

0

[ "PFAM" ]

[ "PF22563" ]

[ "iREC" ]

[ 58 ]

1

[]

0

[]

0

[ "PUB00153788" ]

[ "35609893" ]

[ "Discovering Biological Conflict Systems Through Genome Analysis: Evolutionary Principles and Biochemical Novelty." ]

[ 2022 ]

1

[]

0

null

[ "Pseudomonadati", "metagenomes" ]

[ 56, 2 ]

2

[]

0

true

Domain

Inactive Receiver domain

iREC

9

IPR054593

54,593

Beta-mannosidase-like, galactose-binding domain-like

Beta-mannosidase-like_N2

Domain

20,511

false

This domain is found in a group of proteins belonging to glycosyl hydrolase 2 family (GH2) including beta-mannosidases, beta-glucuronidases and similar sequences [ , , , , ].

[]

0

[ "PFAM" ]

[ "PF22666" ]

[ "Glyco_hydro_2_N2" ]

[ 20511 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.2.1.25", "R-CEL-6798695", "R-CEL-8853383", "R-HSA-6798695", "R-HSA-8853383", "R-MMU-6798695", "R-MMU-8853383", "R-RNO-6798695", "R-RNO-8853383" ]

[ "EC:3.2.1.25", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-8853383", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-8853383", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-8853383", "REACTOME:R-RNO-6798695", "REACTOME:R-RNO-8853383" ]

9

[ "2je8", "2vjx", "2vl4", "2vmf", "2vo5", "2vot", "2vqt", "2vqu", "2vr4", "2vzo", "2vzs", "2vzt", "2vzu", "2vzv", "2wbk", "2x05", "2x09", "4cvu", "4uoj", "5mqm", "5mqn", "5mwk", "5n6u", "6byc", "6bye", "6byg", "6byi", "6ddt", "6ddu", "6q2f", "7kgz", "7op6"...

44

[ "PUB00016274", "PUB00023616", "PUB00024278", "PUB00030015", "PUB00038591" ]

[ "11732897", "8599764", "11045615", "14621996", "16171818" ]

[ "A structural view of the action of Escherichia coli (lacZ) beta-galactosidase.", "Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs.", "High resolution refinement of beta-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a str...

[ 2001, 1996, 2000, 2003, 2005 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 48, 12658, 7638, 167 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 1, 1, 4, 14, 3, 3, 3, 3, 6 ]

10

true

Domain

Beta-mannosidase-like, galactose-binding domain-like

Beta-mannosidase-like_N2

7

IPR054594

54,594

Lon protease, AAA+ ATPase lid domain

Lon_lid

Domain

34,051

false

This entry represents the AAA+ ATPase lid domain of Lon proteases [ , , , , ]. Lon protease belongs to the S16 peptidase family and is an ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins, as well as certain short-lived regulatory proteins. It is required for cellular...

[]

0

[ "PFAM" ]

[ "PF22667" ]

[ "Lon_lid" ]

[ 34051 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.21.53", "R-BTA-9033241", "R-CEL-9033241", "R-CEL-9837999", "R-DDI-9837999", "R-DME-9837999", "R-HSA-390471", "R-HSA-9033241", "R-HSA-9837999", "R-HSA-9841251", "R-MMU-9033241", "R-MMU-9837999", "R-RNO-9033241", "R-RNO-9837999", "R-SCE-9837999", "R-SPO-9837999" ]

[ "EC:3.4.21.53", "REACTOME:R-BTA-9033241", "REACTOME:R-CEL-9033241", "REACTOME:R-CEL-9837999", "REACTOME:R-DDI-9837999", "REACTOME:R-DME-9837999", "REACTOME:R-HSA-390471", "REACTOME:R-HSA-9033241", "REACTOME:R-HSA-9837999", "REACTOME:R-HSA-9841251", "REACTOME:R-MMU-9033241", "REACTOME:R-MMU-983...

16

[ "1qzm", "1x37", "3m6a", "4git", "4ypl", "4ypm", "5e7s", "6n2i", "6on2", "6u5z", "6v11", "6wqh", "7fd4", "7fd5", "7fid", "7fie", "7fiz", "7krz", "7ksl", "7ksm", "7nfy", "7ng4", "7ng5", "7ngc", "7ngf", "7ngl", "7ngp", "7ngq", "7oxo", "7p09", "7p0b", "7p0m"...

55

[ "PUB00000452", "PUB00001838", "PUB00002455", "PUB00002806", "PUB00037475", "PUB00062804", "PUB00062807", "PUB00065410", "PUB00154043", "PUB00154044", "PUB00154045" ]

[ "9425059", "8294008", "3042779", "8226758", "15037242", "10672180", "17216028", "20600124", "24531457", "27041592", "27041593" ]

[ "The lon protease from Mycobacterium smegmatis: molecular cloning, sequence analysis, functional expression, and enzymatic characterization.", "Controlled high-level expression of the lon gene of Escherichia coli allows overproduction of Lon protease.", "Sequence of the lon gene in Escherichia coli. A heat-shoc...

[ 1998, 1993, 1988, 1993, 2004, 2000, 2006, 2010, 2014, 2016, 2016 ]

11

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 23835, 9580, 82, 55, 499 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 20, 2, 2, 2, 1, 13, 5, 2, 8, 8, 1, 1, 42 ]

13

true

Domain

Lon protease, AAA+ ATPase lid domain

Lon_lid

8

IPR054595

54,595

Duffy-binding-like domain, C-terminal subdomain

DBL_C

Domain

2,620

false

This entry represents a domain found C-terminally to Duffy binding-like (DBL, ) domains of PfEMP1 ( ), the adhesin of Plasmodium falciparum which is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors [ , , , , ]. This dom...

[]

0

[ "PFAM" ]

[ "PF22672" ]

[ "DBL_C" ]

[ 2620 ]

1

[]

0

[ "2xu0", "2yk0", "3bqi", "3bqk", "3bql", "7y0j", "8c3y", "8c44", "8vdf", "8vdg", "9bhb", "9naq" ]

12

[ "PUB00021045", "PUB00052735", "PUB00061246", "PUB00066775", "PUB00153904" ]

[ "16051144", "19695262", "22807674", "21402930", "23429057" ]

[ "Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum.", "Structural comparison of two CSPG-binding DBL domains from the VAR2CSA protein important in malaria during pregnancy.", "Structural Basis for the ABO Blood-Group Dependence of Plasmodium falciparum R...

[ 2005, 2009, 2012, 2011, 2013 ]

5

[]

0

null

[ "Plasmodium (Laverania)" ]

[ 2620 ]

1

[]

0

true

Domain

Duffy-binding-like domain, C-terminal subdomain

DBL_C

9

IPR054596

54,596

Mono-ADP-ribosyltransferase PARP14, WWE domain

PARP14_WWE

Domain

1,897

false

This entry represents the WWE domain of protein mono-ADP-ribosyltransferase PARP14 from mouse and similar proteins from vertebrates. PARP14 is an ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins [ ]. It is related to inhibition of STAT1 phosphorylation, however it has ...

[]

0

[ "PFAM" ]

[ "PF22005" ]

[ "WWE_1" ]

[ 1897 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-196807", "R-HSA-9683610", "R-HSA-9694631" ]

[ "REACTOME:R-HSA-196807", "REACTOME:R-HSA-9683610", "REACTOME:R-HSA-9694631" ]

3

[ "1x4r" ]

1

[ "PUB00116104", "PUB00116105" ]

[ "27796300", "29858569" ]

[ "PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.", "On the role of STAT1 and STAT6 ADP-ribosylation in the regulation of macrophage activation." ]

[ 2016, 2018 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 1897 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 2, 2 ]

4

true

Domain

Mono-ADP-ribosyltransferase PARP14, WWE domain

PARP14_WWE

4

IPR054597

54,597

N-acyl amino acid synthase FeeM, catalytic core

FeeM_cat

Domain

2,177

false

This entry represents the catalytic core of the N-acyl amino acid synthase FeeM ( , ). This domain folds into a central antiparallel β-sheet packed on both sides with α-helices and closely resembles the conserved core of members of the GNAT superfamily.

[]

0

[ "PFAM" ]

[ "PF21926" ]

[ "FeeM" ]

[ 2177 ]

1

[]

0

[ "2g0b" ]

1

[ "PUB00040888" ]

[ "16962973" ]

[ "FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2131, 10, 36 ]

3

[]

0

true

Domain

N-acyl amino acid synthase FeeM, catalytic core

FeeM_cat

3

IPR054599

54,599

Transcription factor IIIA, beta-beta-alpha zinc finger

TFIIIA_Zfn-C2H2

Domain

1,355

false

This entry represents a beta-beta-alpha (C2H2-type) zinc finger from TFIIIA, a transcription factor involved in ribosomal large subunit biogenesis. It binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III-dependent transcription and ma...

[]

0

[ "PFAM" ]

[ "PF22110" ]

[ "TFIIIA_zf-C2H2" ]

[ 1355 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-749476", "R-HSA-76061", "R-MMU-76061", "R-RNO-76061" ]

[ "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-MMU-76061", "REACTOME:R-RNO-76061" ]

4

[ "1tf6", "1un6", "2hgh", "2j7j" ]

4

[ "PUB00022799", "PUB00031437", "PUB00062618", "PUB00097261", "PUB00154824" ]

[ "14603324", "9501194", "17335000", "24120868", "2331751" ]

[ "Crystal structure of a zinc-finger-RNA complex reveals two modes of molecular recognition.", "Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex.", "Invariance of the zinc finger module: a comparison of the free structure with those in nucleic-acid ...

[ 2003, 1998, 2007, 2013, 1990 ]

5

[]

0

null

[ "Opisthokonta" ]

[ 1355 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 3, 3 ]

4

true

Domain

Transcription factor IIIA, beta-beta-alpha zinc finger

TFIIIA_Zfn-C2H2

1

IPR054600

54,600

Transcription initiation factor IIE subunit beta, E-tether

TFA2_E-tether

Domain

1,143

false

The small TFIIE subunit Tfa2 (yeast Transcription initiation factor IIE subunit beta) contains two WH domains and two conserved α-helices called the E-tether (represented by this entry) that bind the E-linker [ , ]. Consistent with the structure, the E-tether is essential for TFIIE function and subunit dimerisation. Me...

[]

0

[ "PFAM" ]

[ "PF22254" ]

[ "TFA2_E-tether" ]

[ 1143 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-674695", "R-DDI-6807505", "R-DDI-73776", "R-DDI-73779", "R-DDI-75953", "R-DDI-76042", "R-SCE-674695", "R-SCE-6807505", "R-SCE-73776", "R-SCE-73779", "R-SCE-75953", "R-SCE-76042", "R-SPO-674695", "R-SPO-6807505", "R-SPO-73776", "R-SPO-73779", "R-SPO-75953", "R-SPO-76042" ]

[ "REACTOME:R-DDI-674695", "REACTOME:R-DDI-6807505", "REACTOME:R-DDI-73776", "REACTOME:R-DDI-73779", "REACTOME:R-DDI-75953", "REACTOME:R-DDI-76042", "REACTOME:R-SCE-674695", "REACTOME:R-SCE-6807505", "REACTOME:R-SCE-73776", "REACTOME:R-SCE-73779", "REACTOME:R-SCE-75953", "REACTOME:R-SCE-76042", ...

18

[ "5fyw", "5fz5", "5oqj", "5oqm", "5sva", "6gyl", "6gym", "7ml0", "7ml1", "7ml2", "7ml4", "7o4i", "7o4j", "7o4k", "7o4l", "7o72", "7o73", "7o75", "7zs9", "7zsa", "7zsb", "8cen", "8ceo", "8umh", "8umi", "8uoq", "8uot" ]

27

[ "PUB00154276", "PUB00154277" ]

[ "27193681", "29088706" ]

[ "Transcription initiation complex structures elucidate DNA opening.", "Structures of transcription pre-initiation complex with TFIIH and Mediator." ]

[ 2016, 2017 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1143 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Transcription initiation factor IIE subunit beta, E-tether

TFA2_E-tether

4

IPR054601

54,601

C2185-like, N-terminal

C2185-like_N

Domain

1,584

false

This domain is found at the N-terminal end of the C2185 protein from Clostridium acetobutylicum ( ) and uncharacterised bacterial proteins. This domain is found associated with and shows a NAD(P) binding Rossmann fold.

[]

0

[ "PFAM" ]

[ "PF22674" ]

[ "C2185-like_N" ]

[ 1584 ]

1

[]

0

[ "2g6t", "3nkl" ]

2

[ "PUB00152539" ]

[ "24064219" ]

[ "Biochemical analysis and structure determination of bacterial acetyltransferases responsible for the biosynthesis of UDP-N,N'-diacetylbacillosamine." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Methanospirillum purgamenti", "ecological metagenomes" ]

[ 1550, 1, 33 ]

3

[]

0

true

Domain

C2185-like, N-terminal

C2185-like_N

1

IPR054604

54,604

Surface layer protein, bacterial Ig-like domain

SbsC_Big-like

Domain

367

false

This entry represents bacterial domains that are structurally similar to an immunoglobulin-like domain of intimins (bacterial Ig-like domains, Big-like). Members of this group include Surface layer protein from Geobacillus stearothermophilus ( , ).

[]

0

[ "PFAM" ]

[ "PF22359" ]

[ "Big-like" ]

[ 367 ]

1

[]

0

[ "4uic", "4uid", "4uj6", "5ftx" ]

4

[ "PUB00153834" ]

[ "23794438" ]

[ "Biochemical characterization and crystal structure of a GH10 xylanase from termite gut bacteria reveal a novel structural feature and significance of its bacterial Ig-like domain." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Glossina morsitans morsitans", "Methanobacteriota", "metagenomes" ]

[ 350, 9, 1, 3, 4 ]

5

[]

0

true

Domain

Surface layer protein, bacterial Ig-like domain

SbsC_Big-like

9

IPR054605

54,605

S-layer protein, spectrin-like repeat

SbsA_spectrin-like

Domain

37

false

This entry represents a Spectrin-like domain present in the bacterial S-layer protein from Geobacillus stearothermophilus (SbsA, [ ]) and similar sequences from bacillales. This domain shows structural similarity to the Spectrin domain ( ).

[]

0

[ "PFAM" ]

[ "PF22360" ]

[ "SbsC_spectrin-like" ]

[ 37 ]

1

[]

0

[ "2ra1", "4uic", "4uj6" ]

3

[ "PUB00091547" ]

[ "18682224" ]

[ "The structure and binding behavior of the bacterial cell surface layer protein SbsC." ]

[ 2008 ]

1

[]

0

null

[ "Bacillales" ]

[ 37 ]

1

[]

0

true

Domain

S-layer protein, spectrin-like repeat

SbsA_spectrin-like

3

IPR054606

54,606

NADH:ubiquinone reductase, helical insertion domain

NDH2_hel_ins

Domain

84

false

This entry represent the helical insertion domain of NDH2, a NADH-ubiquinone oxidoreductase from Plasmodium falciparum [ ], an interesting target for antimalarial drug development. This domain seems to be specific to sequences from Apicomplexa.

[]

0

[ "PFAM" ]

[ "PF22365" ]

[ "PfNDH2_hel_ins" ]

[ 84 ]

1

[]

0

[ "5jwa", "5jwb", "5jwc" ]

3

[ "PUB00154098" ]

[ "28195463" ]

[ "Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria." ]

[ 2017 ]

1

[]

0

null

[ "Apicomplexa" ]

[ 84 ]

1

[]

0

true

Domain

NADH:ubiquinone reductase, helical insertion domain

NDH2_hel_ins

4

IPR054607

54,607

Listeria nuclear targeted protein A, helical domain

LntA_helical

Domain

46

false

This entry represents the C-terminal helical domain present in LntA protein, a virulence factor from Listeria monocytogenes [ , ]. LntA targets and inhibits the chromatin repressor BAHD1 in the host cell nucleus to activate interferon-stimulated genes. LntA interacts directly with a central domain of BAHD1 via a surfac...

[]

0

[ "PFAM" ]

[ "PF22390" ]

[ "LntA_helical" ]

[ 46 ]

1

[]

0

[ "2xl4", "4cih" ]

2

[ "PUB00093663", "PUB00154042" ]

[ "24449750", "21252314" ]

[ "Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA.", "A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response." ]

[ 2014, 2011 ]

2

[]

0

null

[ "Listeria" ]

[ 46 ]

1

[]

0

true

Domain

Listeria nuclear targeted protein A, helical domain

LntA_helical

4

IPR054608

54,608

Tyrosine--tRNA ligase SYY-like, C-terminal domain

SYY-like_C

Domain

20,135

false

This entry represents the C-terminal domain of Tyrosine--tRNA ligases which contains the S4 motif that binds RNA [ , , , ]. Members of this group are mainly found in bacteria, including tyrS from Escherichia coli which structure has been determined ( ). TyrS catalyses the attachment of L-tyrosine to tRNA(Tyr) in a two-...

[]

0

[ "PFAM" ]

[ "PF22421" ]

[ "SYY_C-terminal" ]

[ 20135 ]

1

[ "EC" ]

[ "6.1.1.1" ]

[ "EC:6.1.1.1" ]

1

[ "1jh3", "1jii", "1jij", "1jik", "1jil", "2jan", "2ts1", "3ts1", "4oud", "6hb5", "6hb6", "6hb7", "6i5y", "6n0w", "6otj", "7ap3" ]

16

[ "PUB00018354", "PUB00024928", "PUB00025946", "PUB00028507", "PUB00037020", "PUB00154816", "PUB00154817" ]

[ "12005430", "11014183", "11296217", "11007480", "11567092", "4292198", "4579631" ]

[ "Structure and dynamics of the anticodon arm binding domain of Bacillus stearothermophilus Tyrosyl-tRNA synthetase.", "Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics.", "Crystal structures of complexes of the small ribosomal subunit with tetracycline, e...

[ 2002, 2000, 2001, 2000, 2001, 1967, 1973 ]

7

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 18421, 10, 1388, 316 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 3, 3 ]

4

true

Domain

Tyrosine--tRNA ligase SYY-like, C-terminal domain

SYY-like_C

5

IPR054609

54,609

Transcriptional regulatory protein PF0864-like, C-terminal domain

PF0864-like_C

Domain

2,101

false

This entry represents the C-terminal domain of the Transcriptional Regulatory Protein PF0864 from Pyrococcus furiosus and similar prokaryotic proteins. PF0864 is 162 amino acids long and contains an N-terminal HTH asnC-type domain responsible for DNA binding. The crystal structure of PF0864 ( ) reveals a dimeric α-β ba...

[]

0

[ "PFAM" ]

[ "PF22482" ]

[ "AsnC_trans_reg_3" ]

[ 2101 ]

1

[]

0

[ "2ia0" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "metagenomes" ]

[ 43, 2002, 1, 55 ]

4

[]

0

true

Domain

Transcriptional regulatory protein PF0864-like, C-terminal domain

PF0864-like_C

5

IPR054610

54,610

NACHT N-terminal helical domain

NNH

Domain

154

false

This entry represents an helical domain found at the N-terminal of a group of proteins from NACHT conflict systems (named NHH for NACHT N-terminal helical) mainly found in cyanobacteria, including from Rivularia sp. PCC 7116 [ ]. This position is frequently occupied by an effector domain.

[]

0

[ "PFAM" ]

[ "PF22736" ]

[ "NNH5" ]

[ 154 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria" ]

[ 154 ]

1

[]

0

true

Domain

NACHT N-terminal helical domain

NNH

7

IPR054611

54,611

NACHT C-terminal Alpha/Beta domain

NCAB

Domain

169

false

This domain, which contains α-helices and β-strands, is found at the C-terminal of a group of cyanobacterial sequences from NACHT conflict systems [ ].

[]

0

[ "PFAM" ]

[ "PF22724" ]

[ "NCAB1" ]

[ 169 ]

1

[]

0

[]

0

[ "PUB00154095" ]

[ "37160116" ]

[ "Bacterial NLR-related proteins protect against phage." ]

[ 2023 ]

1

[]

0

null

[ "Cyanophyceae" ]

[ 169 ]

1

[]

0

true

Domain

NACHT C-terminal Alpha/Beta domain

NCAB

9

IPR054612

54,612

Phage capsid-like, C-terminal

Phage_capsid-like_C

Domain

16,849

false

This entry represents a domain found in bacteria and viruses (Caudovirales), including bacteriophage capsid proteins. The major capsid protein of Enterobacteria phage HK97 assembles to form an icosahedral capsid [ , ]. Included within the capsid protein is the delta domain which acts as the scaffold upon which the caps...

[]

0

[ "PFAM" ]

[ "PF05065" ]

[ "Phage_capsid" ]

[ 16849 ]

1

[]

0

[ "1if0", "1ohg", "2frp", "2fs3", "2fsy", "2ft1", "2fte", "2gp1", "3ddx", "3e8k", "3j1a", "3qpr", "5tjt", "6b0x", "6b23", "6c21", "6c22", "6okb", "6oma", "6omc", "6tb9", "6tba", "6tsu", "6tsw", "6tui", "7rwz", "8cfa", "8eb4", "8ec2", "8ec8", "8eci", "8ecj"...

54

[ "PUB00046522", "PUB00065553", "PUB00100782" ]

[ "11000116", "21276801", "34362927" ]

[ "Topologically linked protein rings in the bacteriophage HK97 capsid.", "The Prohead-I structure of bacteriophage HK97: implications for scaffold-mediated control of particle assembly and maturation.", "Large-scale computational discovery and analysis of virus-derived microbial nanocompartments." ]

[ 2000, 2011, 2021 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 13, 14222, 34, 2223, 357 ]

5

[]

0

true

Domain

Phage capsid-like, C-terminal

Phage_capsid-like_C

8

IPR054613

54,613

Prohead serine protease domain

Peptidase_S78_dom

Domain

10,169

false

This entry represents the protease domain found in Caudovirus prohead serine proteases and in a number of bacteria possibly as the result of horizontal transfer.

[]

0

[ "PFAM" ]

[ "PF04586" ]

[ "Peptidase_S78" ]

[ 10169 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 10, 8291, 16, 1642, 210 ]

5

[]

0

true

Domain

Prohead serine protease domain

Peptidase_S78_dom

8

IPR054614

54,614

DIP0205-like, N-terminal domain

DIP0205-like_N

Domain

4

false

This domain is found at the N-terminal end of DIP0205 from Corynebacterium diphtheriae ( ) and other putative phage capsid proteins from tailed bacteriophages and bacterial prophages. This domain adopts an α-helical structure. It is often found associated to .

[]

0

[ "PFAM" ]

[ "PF22313" ]

[ "DIP0205-like_N" ]

[ 4 ]

1

[]

0

[ "2r9i" ]

1

[]

0

[]

0

null

[ "Corynebacterium" ]

[ 4 ]

1

[]

0

true

Domain

DIP0205-like, N-terminal domain

DIP0205-like_N

4

IPR054615

54,615

Symporter small accessory protein

Symport_access

Family

271

false

Members of this family share a conserved N-terminal region of about 33 amino acids, with variable length C-terminal regions. As the conserved region is highly hydrophobic, and member proteins are nearly always encoded adjacent to sodium:solute symporter family proteins, typically with coding regions that overlap by at ...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045580", "PF28215" ]

[ "symport_access", "Symport_access" ]

[ 269, 271 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriati", "metagenomes" ]

[ 156, 100, 15 ]

3

[]

0

true

Family

Symporter small accessory protein

Symport_access

9

IPR054617

54,617

Flavin-dependent monooxygenase, oxygenase subunit HsaA

HsaA

Family

1,256

false

This entry represents Flavin-dependent monooxygenase, oxygenase subunit HsaA and related proteins mainly found in Actinomycetes. HsaA catalyses the o-hydroxylation of 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione to 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione in the catabolism of cholesterol [...

[]

0

[ "NCBIFAM" ]

[ "NF045629" ]

[ "monooxsub_HsaA" ]

[ 1256 ]

1

[ "EC", "METACYC" ]

[ "1.14.14.12", "PWY-6944" ]

[ "EC:1.14.14.12", "METACYC:PWY-6944" ]

2

[ "2rfq", "3afe", "3aff" ]

3

[ "PUB00054498" ]

[ "20448045" ]

[ "A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism." ]

[ 2010 ]

1

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 1254, 2 ]

2

[]

0

true

Family

Flavin-dependent monooxygenase, oxygenase subunit HsaA

HsaA

9

IPR054618

54,618

Fructokinase

ScrK

Family

982

false

This entry represents fructokinase ScrK from Lactobacillales, whose amino acid sequence has no significant similarity to fructokinase genes from Klebsiella pneumoniae or Vibrio alginolyticus [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045550" ]

[ "FrctkaseScrK" ]

[ 982 ]

1

[]

0

[]

0

[ "PUB00154715" ]

[ "8336109" ]

[ "Isolation, characterization and sequence analysis of the scrK gene encoding fructokinase of Streptococcus mutans." ]

[ 1993 ]

1

[ "IPR000600" ]

[]

1

0

1

[ "Bacteria" ]

[ 982 ]

1

[]

0

true

Family

Fructokinase

ScrK

3

IPR054619

54,619

Npun_R2821-like

Family

585

false

This entry represents a protein family from Cyanobacteria, including the predicted Sugar transferase Npun_R2821 from Nostoc punctiforme ( ). Members of this entry are almost perfectly matched to the presence of the cyanoexosortase CrtB ( ).

[]

0

[ "NCBIFAM" ]

[ "NF045582" ]

[ "Npun_R2823_gen" ]

[ 585 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 585 ]

1

[]

0

true

Family

Npun_R2821-like

7

IPR054621

54,621

Carboxyl-terminal processing protease CtpA

Cterm_S41_CtpA

Family

297

false

This entry represents a family of proteins from Cyanobacteria, including carboxyl-terminal processing protease A from Synechocystis sp. (CtpA), which processes the photosystem II core complex protein D1 (PsbA) [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045588" ]

[ "Cterm_S41_CtpA" ]

[ 297 ]

1

[]

0

[]

0

[ "PUB00153562", "PUB00154604" ]

[ "8034700", "35269663" ]

[ "Molecular cloning and characterization of the ctpA gene encoding a carboxyl-terminal processing protease. Analysis of a spontaneous photosystem II-deficient mutant strain of the cyanobacterium Synechocystis sp. PCC 6803.", "Processing of D1 Protein: A Mysterious Process Carried Out in Thylakoid Lumen." ]

[ 1994, 2022 ]

2

[ "IPR004447" ]

[]

1

0

1

[ "Cyanobacteriota" ]

[ 297 ]

1

[]

0

true

Family

Carboxyl-terminal processing protease CtpA

Cterm_S41_CtpA

3

IPR054622

54,622

DVU0150-like

Family

78

false

This family includes a group of poorly characterised sequences mainly from Thermodesulfobacteriota, such as DVU0150 ( ) from Desulfovibrio vulgaris [ , ]. Its function is not yet clear but it has been suggested to be involved syntrophic metabolism between D. vulgaris and M. barkeri. [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF040783", "PF28216" ]

[ "DVU0150_fam", "DVU0150" ]

[ 65, 78 ]

2

[]

0

[]

0

[ "PUB00154755", "PUB00154756" ]

[ "19581361", "25504148" ]

[ "The electron transfer system of syntrophically grown Desulfovibrio vulgaris.", "Single-cell analysis reveals gene-expression heterogeneity in syntrophic dual-culture of Desulfovibrio vulgaris with Methanosarcina barkeri." ]

[ 2009, 2014 ]

2

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 76, 2 ]

2

[]

0

true

Family

DVU0150-like

2

IPR054623

54,623

HAH_0734-like

Family

320

false

This uncharacterised protein family is found in halophilic archaea, such as HAH_0734 ( ) from Haloarcula hispanica. It has several conserved motifs WHGP, QLWC and RxYxP. Members of this entry average about 87 amino acids in length and are predicted to adopt a predominantly β-structure with a short α-helix.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045545", "PF23384" ]

[ "HAH_0734_fam", "DUF7098" ]

[ 320, 320 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 320 ]

1

[]

0

true

Family

HAH_0734-like

4

IPR054624

54,624

GDSL lipase Rv0518

GDSL_Rv0518

Family

322

false

This family represents a group of GDSL lipases from Mycobacteriaceae, including Rv0518 from Mycobacterium tuberculosis. Rv0518 catalyses the hydrolysis of p-nitrophenyl (pNP) esters, being pNP-decanoate (C10) the preferred substrate. It can also use pNP-octanoate (C8), pNP-dodecanoate (C12) and pNP-tetradecanoate (C14)...

[]

0

[ "NCBIFAM" ]

[ "NF045548" ]

[ "GDSL_lipase" ]

[ 322 ]

1

[]

0

[]

0

[ "PUB00154697" ]

[ "31125644" ]

[ "Rv0518, a nutritive stress inducible GDSL lipase of Mycobacterium tuberculosis, enhanced intracellular survival of bacteria by cell wall modulation." ]

[ 2019 ]

1

[ "IPR053140" ]

[]

1

0

1

[ "Mycobacteriaceae" ]

[ 322 ]

1

[]

0

true

Family

GDSL lipase Rv0518

GDSL_Rv0518

4

IPR054625

54,625

Carboxyl-terminal processing protease CtpB

Cterm_S41_CtpB

Family

269

false

This entry represents a family of proteins from Cyanobacteria, including carboxyl-terminal protease CtpB from Synechocystis sp. ( ), a paralogue of CtpA ( ) whose exact function has not been yet clarified [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF045589" ]

[ "Cterm_S41_CtpB" ]

[ 269 ]

1

[]

0

[]

0

[ "PUB00153562", "PUB00154604" ]

[ "8034700", "35269663" ]

[ "Molecular cloning and characterization of the ctpA gene encoding a carboxyl-terminal processing protease. Analysis of a spontaneous photosystem II-deficient mutant strain of the cyanobacterium Synechocystis sp. PCC 6803.", "Processing of D1 Protein: A Mysterious Process Carried Out in Thylakoid Lumen." ]

[ 1994, 2022 ]

2

[ "IPR004447" ]

[]

1

0

1

[ "Cyanophyceae" ]

[ 269 ]

1

[]

0

true

Family

Carboxyl-terminal processing protease CtpB

Cterm_S41_CtpB

3

IPR054626

54,626

Carboxyl-terminal processing protease CtpC

Cterm_S41_CtpC

Family

321

false

This entry represents a family of proteins from Cyanobacteria, including carboxyl-terminal protease CtpC from Synechocystis sp. (slr1751, ), a paralogue of CtpA ( ) that may act in crucial housekeeping processes directly linking with survival [ , ]. Its exact function has not been yet clarified [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045590" ]

[ "Cterm_S41_CtpC" ]

[ 321 ]

1

[]

0

[]

0

[ "PUB00153562", "PUB00154604", "PUB00154825" ]

[ "8034700", "35269663", "12244721" ]

[ "Molecular cloning and characterization of the ctpA gene encoding a carboxyl-terminal processing protease. Analysis of a spontaneous photosystem II-deficient mutant strain of the cyanobacterium Synechocystis sp. PCC 6803.", "Processing of D1 Protein: A Mysterious Process Carried Out in Thylakoid Lumen.", "[Stud...

[ 1994, 2022, 2002 ]

3

[ "IPR004447" ]

[]

1

0

1

[ "Cyanobacteriota" ]

[ 321 ]

1

[]

0

true

Family

Carboxyl-terminal processing protease CtpC

Cterm_S41_CtpC

4

IPR054628

54,628

Carboxyl-terminal processing protease CtpZ

Cterm_S41_CtpZ

Family

46

false

This entry represents a family of serine endopeptidases from cyanobacteria that belong to a subgroup distinct from its paralogues in the families of the carboxyl-terminal processing proteases CtpA, CtpB, and CtpC ( , and ). Members are predominantly found in various species of Synechococcus and Prochlorococcus. While C...

[]

0

[ "NCBIFAM" ]

[ "NF045591" ]

[ "Cterm_S41_CtpZ" ]

[ 46 ]

1

[]

0

[]

0

[ "PUB00154603" ]

[ "3526966" ]

[ "[Opioids and reproduction]." ]

[ 1986 ]

1

[ "IPR004447" ]

[]

1

0

1

[ "Cyanophyceae", "Paulinella" ]

[ 41, 5 ]

2

[]

0

true

Family

Carboxyl-terminal processing protease CtpZ

Cterm_S41_CtpZ

3

IPR054629

54,629

Bilirubin reductase, N-terminal domain

BilR_N

Domain

239

false

This entry includes bilirubin reductase from Clostridioides difficile (BilR), as found in the gut microbiome, and similar sequences mainly found in firmicutes. While BilR fom Clostridioides difficile is a monodomain protein, some members of this entry are longer and this constitutes the N-terminal domain, such as in Bi...

[]

0

[ "NCBIFAM" ]

[ "NF045592" ]

[ "bili_reduct_N" ]

[ 239 ]

1

[]

0

[]

0

[ "PUB00154537" ]

[ "38172624" ]

[ "BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen." ]

[ 2024 ]

1

[ "IPR001155" ]

[]

1

0

1

[ "Bacteria", "Piromyces finnis" ]

[ 238, 1 ]

2

[]

0

true

Domain

Bilirubin reductase, N-terminal domain

BilR_N

3

IPR054630

54,630

HTH-type transcriptional regulator BilQ

BilQ

Family

108

false

This entry represents a family of proteins from firmicutes, including HTH-type transcriptional regulator BilQ from Clostridioides difficile. BilQ regulates expression of the bilirubin reductase operon (including bilQ, bilR and bilS) [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045593" ]

[ "bilirub_TF_BilQ" ]

[ 108 ]

1

[]

0

[]

0

[ "PUB00154537" ]

[ "38172624" ]

[ "BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen." ]

[ 2024 ]

1

[]

0

null

[ "Bacillota" ]

[ 108 ]

1

[]

0

true

Family

HTH-type transcriptional regulator BilQ

BilQ

3

IPR054631

54,631

Glycerol facilitator-aquaporin gla

Gla

Family

463

false

This family includes Glycerol facilitator-aquaporin gla, a mixed channel protein that transports both water and glycerol [ ]. Members are specific to Lactobacillales.

[]

0

[ "NCBIFAM" ]

[ "NF045553" ]

[ "AquGlycerPorinGla" ]

[ 463 ]

1

[]

0

[]

0

[ "PUB00154651" ]

[ "11320116" ]

[ "Functional characterization of a microbial aquaglyceroporin." ]

[ 2001 ]

1

[ "IPR000425" ]

[]

1

0

1

[ "Bacteria" ]

[ 463 ]

1

[]

0

true

Family

Glycerol facilitator-aquaporin gla

Gla

3

IPR054632

54,632

Aroma-sacti cluster domain

Aroma_sacti_dom

Domain

267

false

The aroma-sacti cluster domain appears to be found exclusively in biosynthetic gene clusters (BGC) that include both a radical SAM/SPASM domain peptide maturase and RiPP precursor peptide. In some cases, the domain occurs in the N-terminal region of RiPP precursors with known sulfur-to-alpha-carbon (sacti) bonds formed...

[]

0

[ "NCBIFAM", "NCBIFAM" ]

[ "NF045559", "NF045560" ]

[ "sacti_RiPP_CxC", "aroma_sacti_dom" ]

[ 32, 267 ]

2

[]

0

[]

0

[ "PUB00154685" ]

[ "37363077" ]

[ "Catalytic Site Proximity Profiling for Functional Unification of Sequence-Diverse Radical S-Adenosylmethionine Enzymes." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "freshwater metagenome" ]

[ 266, 1 ]

2

[]

0

true

Domain

Aroma-sacti cluster domain

Aroma_sacti_dom

5

IPR054633

54,633

Flavodoxin-like domain-containing protein BilS

BilS

Family

462

false

This entry represents flavodoxin-like domain-containing protein BilS from Clostridioides difficile and similar sequences primarily in Gram-positive bacteria of the gut microbiome. BilS is a flavodoxin-like protein, regularly found in operons with the bilirubin reductase BilR and the MarR family transcriptional regulato...

[]

0

[ "NCBIFAM" ]

[ "NF045594" ]

[ "flavodox_BilS" ]

[ 462 ]

1

[]

0

[]

0

[ "PUB00154537" ]

[ "38172624" ]

[ "BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 460, 2 ]

2

[]

0

true

Family

Flavodoxin-like domain-containing protein BilS

BilS

8

IPR054634

54,634

Type III secretion system effector HrpZ

T3SS_HrpZ

Family

164

false

This family represents Harpin HrpZ from Pseudomonas sp. and similar sequences specific to Pseudomonas species. Harpins are proteins able to elicit hypersensitive response (HR) in non-host plants and are required for pathogenicity in host plants. HrpZ forms ion-conducting pores permeable for cations. Such pore-forming a...

[]

0

[ "NCBIFAM" ]

[ "NF045569" ]

[ "T3SSHrpZ" ]

[ 164 ]

1

[]

0

[]

0

[ "PUB00008686", "PUB00154774", "PUB00154775", "PUB00154776" ]

[ "11134504", "7579616", "15672819", "8324821" ]

[ "HrpZ(Psph) from the plant pathogen Pseudomonas syringae pv. phaseolicola binds to lipid bilayers and forms an ion-conducting pore in vitro.", "The HrpZ proteins of Pseudomonas syringae pvs. syringae, glycinea, and tomato are encoded by an operon containing Yersinia ysc homologs and elicit the hypersensitive resp...

[ 2001, 1995, 2005, 1993 ]

4

[ "IPR006961" ]

[]

1

0

1

[ "Pseudomonas" ]

[ 164 ]

1

[]

0

true

Family

Type III secretion system effector HrpZ

T3SS_HrpZ

3

IPR054635

54,635

PA1571-like

Family

814

false

This entry represents a group of small proteins from gammaproteobacteria, including PA1571 of Pseudomonas aeruginosa ( ), which is homologous to BAL062_00718 from Acinetobacter baumannii, identified by transposon mutagenesis as a likely mediator of reduced sensitivity to colistin [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045613" ]

[ "PA1571_fam" ]

[ 814 ]

1

[]

0

[]

0

[ "PUB00154637" ]

[ "30720421" ]

[ "Clinical and laboratory-induced colistin-resistance mechanisms in Acinetobacter baumannii." ]

[ 2019 ]

1

[]

0

null

[ "Gammaproteobacteria", "marine sediment metagenome" ]

[ 812, 2 ]

2

[]

0

true

Family

PA1571-like

5

IPR054636

54,636

Cytochrome oxidase putative small subunit CydP

CydP

Family

896

false

This entry represents a group of small proteins with a highly hydrophobic core region from proteobacteria, including the cytochrome oxidase putative small subunit CydP [ ]. Members are found in the context of larger subunits of cytochrome bd oxidases, therefore, they are presumed to be a small subunit or assembly facto...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045611", "PF28236" ]

[ "small_CydP", "CydP" ]

[ 867, 885 ]

2

[]

0

[]

0

[ "PUB00154617" ]

[ "35562951" ]

[ "Identification of Key Factors for Anoxic Survival of B. cenocepacia H111." ]

[ 2022 ]

1

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 886, 10 ]

2

[]

0

true

Family

Cytochrome oxidase putative small subunit CydP

CydP

6

IPR054638

54,638

Npun_F0813-like

Family

189

false

Members of this family, including Npun_F0813 from Nostoc punctiforme ( ), are uncharacterised proteins found in cyanobacteria that grow with a filamentous morphology [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045621", "PF24276" ]

[ "Npun_F0813_fam", "DUF7469" ]

[ 181, 189 ]

2

[]

0

[]

0

[ "PUB00154605" ]

[ "20169071" ]

[ "The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications." ]

[ 2010 ]

1

[]

0

null

[ "Cyanobacteriota" ]

[ 189 ]

1

[]

0

true

Family

Npun_F0813-like

2

IPR054639

54,639

Npun_F5560-like

Family

217

false

Members of this family, including Npun_F5560 ( ) from Nostoc punctiforme PCC 73102, appear only in the cyanobacteria, and appear restricted to the subset of cyanobacteria that grow in elongated fibers and form heterocysts for nitrogen fixation. This entry describes full-length homologues of Npun_F5560, and currently ex...

[]

0

[ "NCBIFAM" ]

[ "NF045622" ]

[ "Npun_F5560_fam" ]

[ 217 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 217 ]

1

[]

0

true

Family

Npun_F5560-like

8

IPR054641

54,641

Glutaryl-CoA dehydrogenase ACD

GlutCoADH_Des

Family

60

false

This family includes glutaryl-CoA dehydrogenase ACD from Desulfococcus multivorans, which catalyses the dehydrogenation of Glutaryl-CoA to glutaconyl-CoA [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045552" ]

[ "GlutCoADH_Des" ]

[ 60 ]

1

[]

0

[ "3mpi", "3mpj" ]

2

[ "PUB00154716", "PUB00154717" ]

[ "19395484", "20486657" ]

[ "Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria.", "Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases." ]

[ 2009, 2010 ]

2

[]

0

null

[ "Bacteria" ]

[ 60 ]

1

[]

0

true

Family

Glutaryl-CoA dehydrogenase ACD

GlutCoADH_Des

6

IPR054642

54,642

O-aminophenol oxidase PhsA

AmiPhnlOxPhsA

Family

162

false

This family includes O-aminophenol oxidase PhsA from Streptomyces antibioticus and similar sequences from actinomycetes. It may be involved in the spore pigmentation and melanin production. It catalyses the oxidative coupling of 2-aminophenols to form the 2-aminophenoxazinone chromophore. 2-aminophenoxazinone synthesis...

[]

0

[ "NCBIFAM" ]

[ "NF045554" ]

[ "AmiPhnlOxPhsA" ]

[ 162 ]

1

[]

0

[ "3gyr" ]

1

[ "PUB00130930", "PUB00154684" ]

[ "19268377", "10770769" ]

[ "Phenoxazinone synthase: what's in a name?", "Actinomycin production persists in a strain of Streptomyces antibioticus lacking phenoxazinone synthase." ]

[ 2009, 2000 ]

2

[ "IPR045087" ]

[]

1

0

1

[ "Bacteria" ]

[ 162 ]

1

[]

0

true

Family

O-aminophenol oxidase PhsA

AmiPhnlOxPhsA

8

IPR054643

54,643

Thiopeptide maturation pyridine synthase TbtD/PbtD

TbtD_PbtD_pyrid

Family

155

false

This family represents pyridine synthase synthases for thiopeptide (thiazolyl peptide) maturation, including TbtD in thiomuracin biosynthesis and PbtD ( ) in GE2270A biosynthesis [ , ], which resemble the elimination domain (C-terminal domain) of class I lanthipeptide dehydratases, but those dehydratases convert Ser an...

[]

0

[ "NCBIFAM" ]

[ "NF045556" ]

[ "TbtD_PbtD_pyrid" ]

[ 155 ]

1

[]

0

[ "5w98", "5w99", "5wa3", "5wa4", "8ejy", "8ejz" ]

6

[ "PUB00152393", "PUB00154701", "PUB00154702", "PUB00154703" ]

[ "29158402", "36351243", "26675417", "30653303" ]

[ "Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.", "Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis.", "In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin.", "Thiopeptide Pyridine Synthase TbtD Catalyzes an Intermolecul...

[ 2017, 2022, 2015, 2019 ]

4

[]

0

null

[ "Bacillati" ]

[ 155 ]

1

[]

0

true

Family

Thiopeptide maturation pyridine synthase TbtD/PbtD

TbtD_PbtD_pyrid

3

IPR054644

54,644

Exosortase-dependent surface domain XDD4

Xrt_dep_XDD4

Domain

37

false

This entry represents XDD4 (exosortase-dependent surface domain 4), the fourth in a series of domains or full-length proteins that appear always, or nearly always, to have a C-terminal sorting signal such as PEP-CTERM ( ) that is recognized and processed by XrtA or another exosortase.

[]

0

[ "NCBIFAM" ]

[ "NF045504" ]

[ "Xrt_dep_XDD4" ]

[ 37 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 37 ]

1

[]

0

true

Domain

Exosortase-dependent surface domain XDD4

Xrt_dep_XDD4

6

IPR054645

54,645

Heparin/heparin-sulfate lyase HepB

HepB

Family

127

false

This family represents heparin and heparin-sulfate lyase (HepB, also known as heparinase II), which cleaves both heparin and heparan sulfate glycosaminoglycans through a beta-elimination mechanism. It cleaves heparin at alpha-D-GlcNp2S6S(1->4) alpha-L-IdoAp2S and heparan sulfate at alpha-D-GlcNp2Ac(or 2S)6OH(1->4)beta-...

[]

0

[ "NCBIFAM" ]

[ "NF045571" ]

[ "HepHepsulflyase" ]

[ 127 ]

1

[]

0

[ "2fuq", "2fut", "3e7j", "3e80" ]

4

[ "PUB00016410", "PUB00040822", "PUB00154826" ]

[ "8702264", "16565082", "10747789" ]

[ "Isolation and expression in Escherichia coli of hepB and hepC, genes coding for the glycosaminoglycan-degrading enzymes heparinase II and heparinase III, respectively, from Flavobacterium heparinum.", "Crystal structure of heparinase II from Pedobacter heparinus and its complex with a disaccharide product.", "...

[ 1996, 2006, 2000 ]

3

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 126, 1 ]

2

[]

0

true

Family

Heparin/heparin-sulfate lyase HepB

HepB

8

IPR054646

54,646

Heparin-sulfate lyase HepC

HepC

Family

378

false

This family represents heparin-sulfate lyase (HepC, also known as heparinase III), which specifically cleaves heparan sulfate-rich regions of acidic polysaccharides, it does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. HepC functions in cleaving metazoan heparan sulfate and providi...

[]

0

[ "NCBIFAM", "NCBIFAM" ]

[ "NF045572", "NF045573" ]

[ "Hepsulflyase_bctds", "Hepsulflyase_CFB" ]

[ 120, 258 ]

2

[ "EC", "METACYC" ]

[ "4.2.2.8", "PWY-7651" ]

[ "EC:4.2.2.8", "METACYC:PWY-7651" ]

2

[ "4fnv", "4mmh", "4mmi", "5jmd", "5jmf" ]

5

[ "PUB00016410", "PUB00075988", "PUB00154826" ]

[ "8702264", "23011846", "10747789" ]

[ "Isolation and expression in Escherichia coli of hepB and hepC, genes coding for the glycosaminoglycan-degrading enzymes heparinase II and heparinase III, respectively, from Flavobacterium heparinum.", "Structural basis of heparan sulfate-specific degradation by heparinase III.", "Histidine 295 and histidine 51...

[ 1996, 2012, 2000 ]

3

[]

0

null

[ "Pseudomonadati", "metagenomes" ]

[ 376, 2 ]

2

[]

0

true

Family

Heparin-sulfate lyase HepC

HepC

9

IPR054647

54,647

Gamma-glutamyl-CDP-amidate hydrolase

GCDPHdlase

Family

94

false

This family includes gamma-glutamyl-CDP-amidate hydrolase (GCDPH) from Campylobacter jejuni and similar sequences from campylobacterales. GCDPH is involved in the biosynthesis of the O-methyl phosphoramidate (MeOPN) group found on the capsular polysaccharide (CPS) of C.jejuni [ ]. It catalyses the hydrolysis of CDP-L-g...

[]

0

[ "NCBIFAM" ]

[ "NF045546" ]

[ "GCDPHdlase" ]

[ 94 ]

1

[]

0

[]

0

[ "PUB00096743", "PUB00096744" ]

[ "17675288", "29023101" ]

[ "Commonality and biosynthesis of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni.", "Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni." ]

[ 2007, 2017 ]

2

[ "IPR044668" ]

[]

1

0

1

[ "Campylobacterales" ]

[ 94 ]

1

[]

0

true

Family

Gamma-glutamyl-CDP-amidate hydrolase

GCDPHdlase

7

IPR054648

54,648

TudS-related putative desulfidase

TudS-rel

Family

569

false

Members of this family of prokaryotic proteins typically show weak sequence similarity to , the 2-thiouracil desulfurase (TudS) family. Proteins in this group frequently co-occur with the selenide, water dikinase SelD and with the [Fe8-S9] double-cubane cluster family , plus frequent occurrence in a tandem gene pair wi...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045597", "PF27735" ]

[ "TudS_rel_CD3072", "2-thiour_desulf_put" ]

[ 495, 205 ]

2

[]

0

[]

0

[ "PUB00098595", "PUB00154658", "PUB00154659" ]

[ "29194984", "32929873", "38082046" ]

[ "A gene encoding a DUF523 domain protein is involved in the conversion of 2-thiouracil into uracil.", "Structural Evidence for a [4Fe-5S] Intermediate in the Non-Redox Desulfuration of Thiouracil.", "Publisher Correction: TudS desulfidases recycle 4-thiouridine-5'-monophosphate at a catalytic [4Fe-4S] cluster."...

[ 2018, 2021, 2023 ]

3

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 98, 462, 9 ]

3

[]

0

true

Family

TudS-related putative desulfidase

TudS-rel

9

IPR054649

54,649

Npun_R2479-like

Family

666

false

This family includes Npun_R2479 ( ) from Nostoc punctiforme and similar sequences found primarily in the group of Cyanobacteria that also contain Cyanoexosortase B (CrtB). Members show the HDIG motif of HD domain proteins [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045583", "PF28239" ]

[ "Npun_R2479_HDIG", "Npun_R2479" ]

[ 294, 666 ]

2

[]

0

[]

0

[ "PUB00154669" ]

[ "34094591" ]

[ "The HD-Domain Metalloprotein Superfamily: An Apparent Common Protein Scaffold with Diverse Chemistries." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Orpheovirus IHUMI-LCC2", "ecological metagenomes" ]

[ 638, 7, 1, 20 ]

4

[]

0

true

Family

Npun_R2479-like

6

IPR054650

54,650

Photosystem II high light acclimation Slr0320-like

Slr0320-like

Family

349

false

This entry represents a family of cyanobacterial proteins that contain the radical SAM domain ( ), including Slr0320 from Synechocystis sp. ( ), which is crucial for the functioning of photosystem II upon exposure to high light [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045585" ]

[ "rSAM_slr0320" ]

[ 349 ]

1

[]

0

[]

0

[ "PUB00154601" ]

[ "33810453" ]

[ "Slr0320 Is Crucial for Optimal Function of Photosystem II during High Light Acclimation in Synechocystis sp. PCC 6803." ]

[ 2021 ]

1

[]

0

null

[ "Cyanobacteriota", "Paulinella" ]

[ 344, 5 ]

2

[]

0

true

Family

Photosystem II high light acclimation Slr0320-like

Slr0320-like

5

IPR054651

54,651

Npun_F0494-like

Family

346

false

This entry represents a group of uncharacterised proteins from cyanobacteria, including Npun_F0494 from Nostoc punctiforme ( ). Most members are found encoded next to CobQ ( ). The central motif LRREVDGQGxxxxxRLTPLG is highly conserved.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045586", "PF28240" ]

[ "Npun_F0494_fam", "Npun_F0494" ]

[ 346, 346 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota", "Paulinella" ]

[ 341, 5 ]

2

[]

0

true

Family

Npun_F0494-like

5

IPR054652

54,652

Type IV pilus, essential for biofilm suppression A-like

T4P_EbsA-like

Family

327

false

This entry represents a family of proteins from cyanobacteria, including EbsA (essential for biofilm self-suppression A) from Synechococcus elongatus ( ), a protein that plays a role in both type IV pilus formation and protein secretion across the outer membrane, two processes that rely on the same set of genes [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045587", "PF28241" ]

[ "T4P_biogen_EbsA", "T4P_EbsA" ]

[ 327, 327 ]

2

[]

0

[ "6uf2", "7n82" ]

2

[ "PUB00154602" ]

[ "33727363" ]

[ "A Cyanobacterial Component Required for Pilus Biogenesis Affects the Exoproteome." ]

[ 2021 ]

1

[]

0

null

[ "Cyanobacteriota" ]

[ 327 ]

1

[]

0

true

Family

Type IV pilus, essential for biofilm suppression A-like

T4P_EbsA-like

8

IPR054653

54,653

Exosortase-associated protein EpsI, B-type, predicted

EpsI_type_B_pred

Family

319

false

This entry represents a family of proteobacterial proteins that contain the domain .

[]

0

[ "NCBIFAM" ]

[ "NF045609" ]

[ "EpsI_type_B" ]

[ 319 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota", "ecological metagenomes" ]

[ 316, 3 ]

2

[]

0

true

Family

Exosortase-associated protein EpsI, B-type, predicted

EpsI_type_B_pred

1

IPR054654

54,654

Exosortase-associated protein EpsI, V-type, predicted

EpsI_type_V_pred

Family

101

false

This entry represents a family of proteobacterial proteins that contain the domain . This variant form of EpsI occurs with the type V exosortase, XrtV, involved in sorting a subclass of PEP-CTERM proteins to the cell surface [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045608" ]

[ "EpsI_type_V" ]

[ 101 ]

1

[]

0

[]

0

[ "PUB00034422" ]

[ "16930487" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic." ]

[ 2006 ]

1

[]

0

null

[ "Alphaproteobacteria", "hydrothermal vent metagenome" ]

[ 100, 1 ]

2

[]

0

true

Family

Exosortase-associated protein EpsI, V-type, predicted

EpsI_type_V_pred

6

IPR054655

54,655

Sorting system accessory protein XrtV-like

XrtV-like

Family

136

false

Members of this hydrophobic protein family are found associated with the protein-sorting cysteine endopeptidase XrtV (exosortase V as in Victor), and likely participate in the proper targeting and localisation of client PEP-CTERM proteins. The system is mainly seen in Sphingomonadales.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045607", "PF28242" ]

[ "exo_Victor_syst", "XrtV" ]

[ 136, 136 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaproteobacteria", "hydrothermal vent metagenome" ]

[ 134, 2 ]

2

[]

0

true

Family

Sorting system accessory protein XrtV-like

XrtV-like

2

IPR054656

54,656

DVU_1557-like

Family

329

false

This family of putative redox proteins includes DVU_1557 ( ) from Desulfovibrio vulgaris, as well as the related paralogues from Clostridium ljungdahlii. Members of this family are found in an extended conserved gene neighborhood that also includes a molybdopterin-dependent aldehyde oxidoreductase and the radical SAM (...

[]

0

[ "NCBIFAM" ]

[ "NF045645" ]

[ "DVU_1557_fam" ]

[ 329 ]

1

[]

0

[]

0

[ "PUB00154723" ]

[ "29030620" ]

[ "Transcriptomic profiles of Clostridium ljungdahlii during lithotrophic growth with syngas or H2 and CO2 compared to organotrophic growth with fructose." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 318, 11 ]

2

[]

0

true

Family

DVU_1557-like

1

IPR054657

54,657

Putative T6SS immunity periplasmic lipoprotein

T6SS_periplasmic_put

Family

643

false

Members of this family, including SARI_02726 ( ) from Salmonella enterica subsp. arizonae and EC042_4532 ( ) from sequence type ST31 strains of enteroaggregative Escherichia coli, are associated with type VI secretion systems (T6SS), and suggested to be immunity proteins with periplasmic localization. A well-conserved ...

[]

0

[ "NCBIFAM" ]

[ "NF045617" ]

[ "mostly_LP" ]

[ 643 ]

1

[]

0

[]

0

[ "PUB00100134", "PUB00154618" ]

[ "31577948", "32366874" ]

[ "The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology.", "Identification and characterisation of enteroaggregative Escherichia coli subtypes associated with human disease." ]

[ 2019, 2020 ]

2

[]

0

null

[ "Pseudomonadota" ]

[ 643 ]

1

[]

0

true

Family

Putative T6SS immunity periplasmic lipoprotein

T6SS_periplasmic_put

8

IPR054658

54,658

Extracytoplasmic lipoprotein

Extrcyto_LP

Family

86

false

Members of this family are found primarily in the genus Acinetobacter. These proteins have four widely spaced invariant Cys residues, suggesting an extracytoplasmic (surface or periplasmic) location. About half the members of this family have an apparent lipoprotein signal peptide.

[]

0

[ "NCBIFAM" ]

[ "NF045616" ]

[ "Acin_mostly_LP" ]

[ 86 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Moraxellaceae" ]

[ 86 ]

1

[]

0

true

Family

Extracytoplasmic lipoprotein

Extrcyto_LP

9

IPR054659

54,659

J517_1871 lipoprotein-like

J517_1871_lipoprot

Family

88

false

This entry represents a group of proteins commonly found in Acinetobacter and Acinetobacter phages, which are predicted lipoproteins. Many members contain a lipid attachment site and are predicted to show an extensive β-sheet structure.

[]

0

[ "NCBIFAM" ]

[ "NF045606" ]

[ "lipo_J517_1871" ]

[ 88 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota", "Vieuvirus" ]

[ 86, 2 ]

2

[]

0

true

Family

J517_1871 lipoprotein-like

J517_1871_lipoprot

6

IPR054660

54,660

Cation efflux protein, CzcI-like

CzcI-like

Family

323

false

This entry represents a family of proteins mainly found in Acinetobacter species. Members are metal resistance efflux proteins, related to the cobalt-zinc-cadmium transporter protein CzcI [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045615", "PF28244" ]

[ "efflu_CzcI_Acin", "CzcI" ]

[ 253, 323 ]

2

[]

0

[]

0

[ "PUB00154794" ]

[ "32117089" ]

[ "Characterization of Acinetobacter baumannii Copper Resistance Reveals a Role in Virulence." ]

[ 2020 ]

1

[]

0

null

[ "Pseudomonadota", "marine sediment metagenome" ]

[ 321, 2 ]

2

[]

0

true

Family

Cation efflux protein, CzcI-like

CzcI-like

4

IPR054661

54,661

Scytonemin biosynthesis sensor histidine kinase Npun_F1277-like

Npun_F1277-like

Family

49

false

This entry represents a family of cyanobacterial sequences, including the histidine kinase Npun_F1277 from Nostoc punctiforme ( ), part of a two-component regulatory system encoded upstream of the scytonemin gene cluster [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045595" ]

[ "HK_scytonemin" ]

[ 49 ]

1

[]

0

[]

0

[ "PUB00154785" ]

[ "27020740" ]

[ "The response regulator Npun_F1278 is essential for scytonemin biosynthesis in the cyanobacterium Nostoc punctiforme ATCC 29133." ]

[ 2016 ]

1

[ "IPR050736" ]

[]

1

0

1

[ "Cyanophyceae" ]

[ 49 ]

1

[]

0

true

Family

Scytonemin biosynthesis sensor histidine kinase Npun_F1277-like

Npun_F1277-like

6

IPR054662

54,662

PT dipeptide repeat lipoprotein

Lipo_PTPT

Family

120

false

This entry represents a group of uncharacterised proteins found in proteobacteria. Members of this group show an N-terminal lipoprotein signal peptide, followed by a variable length stretch of Pro-Thr dipeptide repeats or a related Pro-rich region and the non-repetitive domain.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045612", "PF28245" ]

[ "lipo_PTPT", "Lipo_PTPT" ]

[ 53, 120 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati" ]

[ 120 ]

1

[]

0

true

Family

PT dipeptide repeat lipoprotein

Lipo_PTPT

6

IPR054663

54,663

Filament integrity protein FraC

FraC

Family

201

false

This entry represents the Filament integrity protein FraC and related proteins found in cyanobacteria. FraC, along with FraD and SepJ (FraG), is found at intercellular septa in heterocyst-forming filamentous cyanobacteria such as Nostoc punctiforme. This protein is involved in filament integrity and is required for the...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045624", "PF24301" ]

[ "filament_FraC", "FraC" ]

[ 196, 201 ]

2

[]

0

[]

0

[ "PUB00154607", "PUB00154608", "PUB00154609" ]

[ "20487302", "38164507", "25784700" ]

[ "Fra proteins influencing filament integrity, diazotrophy and localization of septal protein SepJ in the heterocyst-forming cyanobacterium Anabaena sp.", "Complete Genome Sequence of Annamia dubia, filamentous colony-making Chroococcales with the analysis of FraC gene influencing filament integrity.", "I...

[ 2010, 2024, 2015 ]

3

[]

0

null

[ "Cyanobacteriota" ]

[ 201 ]

1

[]

0

true

Family

Filament integrity protein FraC

FraC

2

IPR054664

54,664

Alr0857-like

Family

239

false

This entry includes uncharacterised proteins, including Alr0857 protein ( ) from Nostoc sp., that are found predominantly in cyanobacteria [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045647", "PF28246" ]

[ "alr0857_fam", "Alr0857" ]

[ 237, 239 ]

2

[]

0

[]

0

[ "PUB00154605" ]

[ "20169071" ]

[ "The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications." ]

[ 2010 ]

1

[]

0

null

[ "Cyanobacteriota" ]

[ 239 ]

1

[]

0

true

Family

Alr0857-like

4

IPR054665

54,665

ZirU-like domain

ZirU-like_dom

Domain

792

false

This entry represents a domain that covers the whole protein length in ZirU from Salmonella, which shares with ZirS the property of requiring ZirT for its type Vb-like secretion and is homologous to immunoglobulin superfamily members [ ]. It is also found at the C-terminal end of several uncharacterised proteins. Membe...

[]

0

[ "NCBIFAM" ]

[ "NF040485" ]

[ "ZirU_fam" ]

[ 792 ]

1

[]

0

[]

0

[ "PUB00061238" ]

[ "22810234" ]

[ "The Zinc Regulated Antivirulence Pathway of Salmonella is a Multi-protein Immunoglobulin Adhesion System." ]

[ 2012 ]

1

[]

0

null

[ "Anopheles maculatus", "Gammaproteobacteria" ]

[ 1, 791 ]

2

[]

0

true

Domain

ZirU-like domain

ZirU-like_dom

1

IPR054666

54,666

Sactipeptide maturase StsB

Sacti_mat_StsB

Family

46

false

Members of this family are radical SAM/SPASM enzymes that modify RiPP precursor peptides to introduce sulfur-to-alpha-carbon amino acid side chain crosslinks. Peptides modified in this way are often called sactipeptides, therefore, this family of proteins has been called radical SAM/SPASM domain sactipeptide maturase S...

[]

0

[ "NCBIFAM" ]

[ "NF045574" ]

[ "sacti_mat_StsB" ]

[ 46 ]

1

[]

0

[]

0

[ "PUB00154685" ]

[ "37363077" ]

[ "Catalytic Site Proximity Profiling for Functional Unification of Sequence-Diverse Radical S-Adenosylmethionine Enzymes." ]

[ 2023 ]

1

[ "IPR050377" ]

[]

1

0

1

[ "Bacteria" ]

[ 46 ]

1

[]

0

true

Family

Sactipeptide maturase StsB

Sacti_mat_StsB

4

IPR054667

54,667

Methanobactin export MATE transporter MbnM

Export_MbnM

Family

22

false

Members of this family of MATE type efflux transporter occur in methanobactin biosynthesis loci and are presumed to function in the export of methanobactin, a siderophore analog that is synthesized, exported so that it can bind copper ion with high affinity, and then reimported [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045578" ]

[ "export_MbnM" ]

[ 22 ]

1

[]

0

[]

0

[ "PUB00154719" ]

[ "29305514" ]

[ "Metals and Methanotrophy." ]

[ 2018 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 22 ]

1

[]

0

true

Family

Methanobactin export MATE transporter MbnM

Export_MbnM

7

IPR054668

54,668

Methanobactin biosynthesis FAD monooxygenase MbnF-like

FAD_mono_MbnF-like

Family

9

false

This entry represents a group of uncharacterised proteins from Hyphomicrobiales, including Methanobactin biosynthesis FAD monooxygenase MbnF from Methylocystis borbori. Methanobactins (MBs) are ribosomally produced and post-translationally modified peptides (RiPPs) that are used by methanotrophs for copper acquisition....

[]

0

[ "NCBIFAM" ]

[ "NF045577" ]

[ "FAD_mono_MbnF" ]

[ 9 ]

1

[]

0

[ "8fhj" ]

1

[ "PUB00154790", "PUB00154791" ]

[ "34510894", "37158309" ]

[ "Characterization of a Copper-Chelating Natural Product from the Methanotroph Methylosinus sp. LW3.", "Crystal structure of MbnF: an NADPH-dependent flavin monooxygenase from Methylocystis strain SB2." ]

[ 2021, 2023 ]

2

[ "IPR050641" ]

[]

1

0

1

[ "Methylocystaceae" ]

[ 9 ]

1

[]

0

true

Family

Methanobactin biosynthesis FAD monooxygenase MbnF-like

FAD_mono_MbnF-like

5

IPR054669

54,669

Gamma-glutamylputrescine synthetase

GGputSyn

Family

38

false

This family includes Gamma-glutamylputrescine synthetase from Haloferax mediterranei and related sequences from halobacteria. It is involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine. It is not required for glutamine synthesis [ ] and it is not able to compensate for the loss of ...

[]

0

[ "NCBIFAM" ]

[ "NF045547" ]

[ "GGputSyn" ]

[ 38 ]

1

[]

0

[]

0

[ "PUB00154711", "PUB00154712" ]

[ "32296946", "34439822" ]

[ "Essentiality of the glnA gene in Haloferax mediterranei: gene conversion and transcriptional analysis.", "Novel Glutamate-Putrescine Ligase Activity in Haloferax mediterranei: A New Function for glnA-2 Gene." ]

[ 2020, 2021 ]

2

[]

0

null

[ "Halobacteriales" ]

[ 38 ]

1

[]

0

true

Family

Gamma-glutamylputrescine synthetase

GGputSyn

4

IPR054670

54,670

Type IV CRISPR-associated endonuclease Csf5

Cas6_csf5

Family

16

false

This entry represents the type IV CRISPR-associated endonuclease Csf5 from Aromatoleum aromaticum ( ) and similar bacterial sequences [ ]. Csf5 generates CRISPR RNAs (crRNAs) that are specifically incorporated into type IV CRISPR-ribonucleoprotein (crRNP) complexes.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045575", "PF28248" ]

[ "cas6_csf5", "Cas6_csf5" ]

[ 5, 16 ]

2

[]

0

[ "6h9h", "6h9i", "7xfz", "7xg0", "7xg2", "7xg3", "7xg4", "8rc3", "8rfj" ]

9

[ "PUB00154718" ]

[ "30397343" ]

[ "Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum." ]

[ 2019 ]

1

[]

0

null

[ "Pseudomonadati" ]

[ 16 ]

1

[]

0

true

Family

Type IV CRISPR-associated endonuclease Csf5

Cas6_csf5

7

IPR054671

54,671

ATP-dependent glucokinase, pyrobaculum-type

GK_pyrobaculum-type

Family

13

false

This small family of proteins includes glucokinase (also known as Pcal_1032) from Pyrobaculum calidifontis and related sequences from Thermoproteaceae. These proteins belong to the ROK family of sugar kinases and catalyse the phosphorylation of D-glucose to D-glucose 6-phosphate using ATP as the phosphate donor. It has...

[]

0

[ "NCBIFAM" ]

[ "NF045551" ]

[ "GK_Pyrobac" ]

[ 13 ]

1

[]

0

[]

0

[ "PUB00154768" ]

[ "29275440" ]

[ "Enhancement of gene expression in Escherichia coli and characterization of highly stable ATP-dependent glucokinase from Pyrobaculum calidifontis." ]

[ 2018 ]

1

[ "IPR000600" ]

[]

1

0

1

[ "Thermoproteaceae" ]

[ 13 ]

1

[]

0

true

Family

ATP-dependent glucokinase, pyrobaculum-type

GK_pyrobaculum-type

1

IPR054672

54,672

Sactipeptide RiPP StsA

StsA_sacti_RiPP

Family

10

false

Members of this small family are encoded next to the radical SAM enzyme StsB, and are average about 40 amino acids in length. Maturation involves the introduction of three sulfur-to-alpha carbon thioether (sactionine) crosslinks, from the Cys residues in the motif CxCxC to glycines in a nearby motif GxGxG that runs ant...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045558", "PF28249" ]

[ "StsA_sacti_RiPP", "StsA_sacti_RiPP" ]

[ 9, 10 ]

2

[]

0

[]

0

[ "PUB00154685" ]

[ "37363077" ]

[ "Catalytic Site Proximity Profiling for Functional Unification of Sequence-Diverse Radical S-Adenosylmethionine Enzymes." ]

[ 2023 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 10 ]

1

[]

0

true

Family

Sactipeptide RiPP StsA

StsA_sacti_RiPP

7

IPR054673

54,673

Putative four-helix membrane protein

Four_helix_put

Family

15

false

This entry represents a group of uncharacterised proteins from Acinetobacter that are predicted to show four α-helices, the first of which is likely to be a signal peptide.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF045610", "PF28250" ]

[ "acin_4_helix", "Four_helix_put" ]

[ 15, 15 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Acinetobacter" ]

[ 15 ]

1

[]

0

true

Family

Putative four-helix membrane protein

Four_helix_put

9

IPR054674

54,674

4-aminobenzoate N-oxygenase AurF

Diiron_AurF

Family

13

false

This entry represents 4-aminobenzoate N-oxygenase from Streptomyces thioluteus (AurF) are similar proteins. AurF is a di-iron oxygenase encoded in a polyketide synthase-type biosynthetic gene cluster that produce aureothin. It is a 4-aminobenzoate N-oxygenase ( ) enzyme [ , , , ]. This family is specific to Streptomyce...

[]

0

[ "NCBIFAM" ]

[ "NF045603" ]

[ "diiron_AurF" ]

[ 13 ]

1

[]

0

[ "2jcd", "3chh", "3chi", "3cht", "3chu" ]

5

[ "PUB00051000", "PUB00154686", "PUB00154829", "PUB00154830", "PUB00154831" ]

[ "18458342", "17763486", "15038705", "16927313", "20798054" ]

[ "In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.", "Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective.", "Biosynthetic origin of the rare nitroaryl moiety of the polyketide antibiot...

[ 2008, 2007, 2004, 2006, 2010 ]

5

[ "IPR025859" ]

[]

1

0

1

[ "Actinomycetes" ]

[ 13 ]

1

[]

0

true

Family

4-aminobenzoate N-oxygenase AurF

Diiron_AurF

9

IPR054676

54,676

Hydrolase HsaD

HsaD

Family

776

false

This entry represents 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolasefrom Mycobacterium tuberculosis (HsaD) and related proteins from actinomycetes. HsaD catalyses the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate to yield 9,17...

[]

0

[ "NCBIFAM" ]

[ "NF045632" ]

[ "hydroxlase_HsaD" ]

[ 776 ]

1

[ "EC", "METACYC" ]

[ "3.7.1.17", "PWY-6944" ]

[ "EC:3.7.1.17", "METACYC:PWY-6944" ]

2

[ "2vf2", "2wud", "2wue", "2wuf", "2wug", "5jz9", "5jzb", "5jzs", "7zjt", "7zm1", "7zm2", "7zm3", "7zm4" ]

13

[ "PUB00049709", "PUB00066117", "PUB00124068", "PUB00154687" ]

[ "18097091", "19875455", "16233225", "17264217" ]

[ "Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis.", "Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.", "Diversity of 2,3-dihydroxybiphenyl dioxygenase genes in a strong PCB degrader, Rhodococcus sp. strain RHA1."...

[ 2008, 2010, 2002, 2007 ]

4

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 774, 2 ]

2

[]

0

true

Family

Hydrolase HsaD

HsaD

6

IPR054677

54,677

Lipid A 4'-phosphatase

LpxF

Family

29

false

This entry represents the Lipid A 4'-phosphatase from Francisella tularensis (LpxF) and related proteins. This enzyme removes the 4'-phosphate moiety from the tetraacylated precursor of lipid A and from pentaacylated lipid A, but not from hexaacylated lipid A which is found in E.coli. Its expression in E.coli confers r...

[]

0

[ "NCBIFAM" ]

[ "NF045633" ]

[ "LipidAPhtaseLpxF" ]

[ 29 ]

1

[]

0

[]

0

[ "PUB00154769", "PUB00154770", "PUB00154832" ]

[ "16467300", "17263332", "17360489" ]

[ "Expression cloning and periplasmic orientation of the Francisella novicida lipid A 4'-phosphatase LpxF.", "Characterization of lipid A acylation patterns in Francisella tularensis, Francisella novicida, and Francisella philomiragia using multiple-stage mass spectrometry and matrix-assisted laser desorption/ioniz...

[ 2006, 2007, 2007 ]

3

[]

0

null

[ "Francisellaceae" ]

[ 29 ]

1

[]

0

true

Family

Lipid A 4'-phosphatase

LpxF

4

IPR054678

54,678

Beta-carotene hydroxylase CrtR-like

CrtR-like

Family

353

false

This entry represents a group of proteins from cyanobacteria, including Beta-carotene hydroxylase from Synechocystis sp. (CrtR, ), which is involved both in zeaxanthin and myxoxanthophyll synthesis [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045688" ]

[ "BCarotHydoxCrtR" ]

[ 353 ]

1

[]

0

[]

0

[ "PUB00008469" ]

[ "10431816" ]

[ "The zeaxanthin biosynthesis enzyme beta-carotene hydroxylase is involved in myxoxanthophyll synthesis in Synechocystis sp. PCC 6803." ]

[ 1999 ]

1

[ "IPR012171" ]

[]

1

0

1

[ "Cyanobacteriota", "Paulinella" ]

[ 349, 4 ]

2

[]

0

true

Family

Beta-carotene hydroxylase CrtR-like

CrtR-like

4

IPR054679

54,679

Beta-carotene ketolase CrtO-like

CrtO-like

Family

266

false

This entry represents a group of proteins from cyanobacteria, including Beta-carotene ketolase CrtO (all3744, ) from Anabaena sp. (Nostoc), which catalyse the conversion of beta-carotene to echinenone [ ]. This protein is not required for normal growth under standard or high light conditions [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045689" ]

[ "BCarotKetCrtO" ]

[ 266 ]

1

[]

0

[]

0

[ "PUB00154786", "PUB00154787", "PUB00154788" ]

[ "17415558", "9092504", "16242129" ]

[ "Characterization of two beta-carotene ketolases, CrtO and CrtW, by complementation analysis in Escherichia coli.", "A new type of asymmetrically acting beta-carotene ketolase is required for the synthesis of echinenone in the cyanobacterium Synechocystis sp. PCC 6803.", "The cyanobacterium Anabaena sp. PCC 712...

[ 2007, 1997, 2005 ]

3

[]

0

null

[ "Cyanophyceae" ]

[ 266 ]

1

[]

0

true

Family

Beta-carotene ketolase CrtO-like

CrtO-like

5

IPR054680

54,680

Iron-dependent extradiol dioxygenase

HsaC

Family

889

false

This entry represents Iron-dependent extradiol dioxygenase from Mycobacterium tuberculosis (HsaC). and similar sequences specific to actinomycetes. This enzyme catalyses the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-di...

[]

0

[ "NCBIFAM" ]

[ "NF045631" ]

[ "exdiol_diox_HsaC" ]

[ 889 ]

1

[ "EC", "METACYC" ]

[ "1.13.11.25", "PWY-6944" ]

[ "EC:1.13.11.25", "METACYC:PWY-6944" ]

2

[ "2zi8", "2zyq" ]

2

[ "PUB00054462", "PUB00124068", "PUB00154687" ]

[ "19300498", "16233225", "17264217" ]

[ "Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.", "Diversity of 2,3-dihydroxybiphenyl dioxygenase genes in a strong PCB degrader, Rhodococcus sp. strain RHA1.", "A gene cluster encoding cholesterol catabolism in a soil acti...

[ 2009, 2002, 2007 ]

3

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 887, 2 ]

2

[]

0

true

Family

Iron-dependent extradiol dioxygenase

HsaC

3

IPR054681

54,681

Beta-carotene ketolase CrtW-like

CrtW-like

Family

125

false

This entry represents a group of proteins from cyanobacteria that contain the fatty acid desaturase domain ( ), including beta-carotene ketolase CrtW (alr3189, ) from Nostoc, which catalyses the conversion of myxol 2'-fucoside to ketomyxol 2'-fucosid [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045690" ]

[ "BCarotKetCrtW" ]

[ 125 ]

1

[]

0

[]

0

[ "PUB00154788", "PUB00154789" ]

[ "16242129", "15269553" ]

[ "The cyanobacterium Anabaena sp. PCC 7120 has two distinct beta-carotene ketolases: CrtO for echinenone and CrtW for ketomyxol synthesis.", "Cloning of two carotenoid ketolase genes from Nostoc punctiforme for the heterologous production of canthaxanthin and astaxanthin." ]

[ 2005, 2004 ]

2

[]

0

null

[ "Cyanophyceae" ]

[ 125 ]

1

[]

0

true

Family

Beta-carotene ketolase CrtW-like

CrtW-like

3

IPR054682

54,682

Flavin-dependent monooxygenase, reductase subunit HsaB

HsaB

Family

834

false

This entry represents Flavin-dependent monooxygenase, reductase subunit, known as HsaB. HsaB catalyses the reduction of free flavins (FMN or FAD) by NADH. Subsequently, the reduced flavins diffuse to the HsaA oxygenase subunit [ ]. Members of this family are found exclusively in Actinomycetes.

[]

0

[ "NCBIFAM" ]

[ "NF045630" ]

[ "monooxsub_HsaB" ]

[ 834 ]

1

[ "EC" ]

[ "1.5.1.36" ]

[ "EC:1.5.1.36" ]

1

[ "3nfw" ]

1

[ "PUB00054498", "PUB00154687" ]

[ "20448045", "17264217" ]

[ "A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism.", "A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages." ]

[ 2010, 2007 ]

2

[ "IPR050268" ]

[]

1

0

1

[ "Actinomycetes" ]

[ 834 ]

1

[]

0

true

Family

Flavin-dependent monooxygenase, reductase subunit HsaB

HsaB

6

IPR054683

54,683

2'-O-glycosyltransferase CruG-like

CruG-like

Family

276

false

This entry represents a group of proteins from cyanobacteria, including 2'-O-glycosyltransferase CruG ( ) from Picosynechococcus sp. [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045692" ]

[ "OglycostaseCruG" ]

[ 276 ]

1

[]

0

[]

0

[ "PUB00154614" ]

[ "19304845" ]

[ "The biosynthetic pathway for myxol-2' fucoside (myxoxanthophyll) in the cyanobacterium Synechococcus sp. strain PCC 7002." ]

[ 2009 ]

1

[]

0

null

[ "Cyanobacteriota" ]

[ 276 ]

1

[]

0

true

Family

2'-O-glycosyltransferase CruG-like

CruG-like

4

IPR054685

54,685

RCKP-type rubredoxin-like

Rubredox_RCKP

Family

115

false

This entry represents a group of bacterial uncharacterised sequences that contain a variant form of rubredoxin-like proteins that often covers its full-length, about 35 amino acids long. Of the five distinctive highly conserved Cys residues, the first two and last two are shared with typical rubredoxin-like domains, bu...

[]

0

[ "NCBIFAM" ]

[ "NF045720" ]

[ "rubredox_RCKP" ]

[ 115 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Odinarchaeota yellowstonii (strain LCB_4)", "ecological metagenomes" ]

[ 109, 1, 5 ]

3

[]

0

true

Family

RCKP-type rubredoxin-like

Rubredox_RCKP

9

IPR054687

54,687

Two-CW domain

Two-CW_dom

Domain

211

false

The two-CW domain is a bacterial domain of up to 81-residues in its long form that shows strongly conserved motifs with six invariant Cys residues. A shorter form exists, with gaps at both sides of the motifs, that includes the third invariant Cys. The domain is named for CW dipeptides in the two strongest motifs, the ...

[]

0

[ "NCBIFAM" ]

[ "NF045718" ]

[ "two_CW_domain" ]

[ 211 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanomicrobia", "ecological metagenomes" ]

[ 190, 6, 15 ]

3

[]

0

true

Domain

Two-CW domain

Two-CW_dom

5

IPR054689

54,689

Lipid acquisition surface protein MG075-like

MG075-like

Family

45

false

This entry represents the uncharacterised protein MG075 homolog from Mycoplasma pneumoniae (MPN_213) and similar sequences from Mycoplasmatota. MG075, named P116, is an essential surface protein, shown to form a homodimer with a large hydrophobic cavity, and to play a role in obtaining lipids such as phosphatidylcholin...

[]

0

[ "NCBIFAM" ]

[ "NF045696" ]

[ "MG075_fam" ]

[ 45 ]

1

[]

0

[ "8a9a", "8a9b", "9fch" ]

3

[ "PUB00154800", "PUB00154801" ]

[ "36782049", "21144026" ]

[ "Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas.", "Identification of an N-terminal 27 kDa fragment of Mycoplasma pneumoniae P116 protein as specific immunogen in M. pneumoniae infections." ]

[ 2023, 2010 ]

2

[]

[ "IPR057145" ]

0

1

0

[ "Mycoplasmatota" ]

[ 45 ]

1

[]

0

true

Family

Lipid acquisition surface protein MG075-like

MG075-like

5

IPR054690

54,690

DNA polymerase I, 3'-5' exonuclease domain

DNA_polI_exonuclease

Domain

8,862

false

This entry represents a domain found in DNA polymerase I from Geobacillus stearothermophilus and similar sequences mainly from actinomycetes and firmicutes. In addition to polymerase activity, this enzyme has strand displacement and 5'-3' exonuclease activity, but lacks proofreading 3'-5' exonuclease activity [ , ]. Th...

[]

0

[ "PFAM" ]

[ "PF22619" ]

[ "DNA_polI_exo1" ]

[ 8862 ]

1

[ "EC" ]

[ "2.7.7.7" ]

[ "EC:2.7.7.7" ]

1

[ "1l3s", "1l3t", "1l3u", "1l3v", "1l5u", "1lv5", "1njw", "1njx", "1njy", "1njz", "1nk0", "1nk4", "1nk5", "1nk6", "1nk7", "1nk8", "1nk9", "1nkb", "1nkc", "1nke", "1u45", "1u47", "1u48", "1u49", "1u4b", "1ua0", "1ua1", "1xc9", "1xwl", "2bdp", "2hhq", "2hhs"...

132

[ "PUB00032537", "PUB00154833" ]

[ "9016716", "8679703" ]

[ "Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution.", "Construction of single amino acid substitution mutants of cloned Bacillus stearothermophilus DNA polymerase I which lack 5'-->3' exonuclease activity." ]

[ 1997, 1996 ]

2

[ "IPR002562" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8741, 5, 116 ]

3

[]

0

true

Domain

DNA polymerase I, 3'-5' exonuclease domain

DNA_polI_exonuclease

3

IPR054691

54,691

2-isopropylmalate synthase/homocitrate synthase, post-catalytic domain

LeuA/HCS_post-cat

Domain

30,890

false

This entry represents a domain found centrally in 2-isopropylmalate synthase from Neisseria meningitidis (LeuA) [ ], homocitrate synthase from Sulfolobus acidocaldarius (HCS) [ , ] and similar proteins found in all cellular organisms. This domain follows the catalytic domain and is required for the enzymatic activity.

[]

0

[ "PFAM" ]

[ "PF22617" ]

[ "HCS_D2" ]

[ 30890 ]

1

[ "EC", "EC", "METACYC" ]

[ "2.3.3", "2.3.3.13", "PWY-6871" ]

[ "EC:2.3.3", "EC:2.3.3.13", "METACYC:PWY-6871" ]

3

[ "2ztj", "2ztk", "2zyf", "3a9i", "3eeg", "3ivs", "3ivt", "3ivu", "3mi3", "3rmj", "6e1j", "6ktq" ]

12

[ "PUB00054765", "PUB00065745", "PUB00154834" ]

[ "19776021", "22352945", "32897601" ]

[ "Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.", "Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate binding.", "Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crys...

[ 2009, 2012, 2021 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2096, 24108, 3961, 725 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 24, 1, 2, 5, 2, 1, 32 ]

7

true

Domain

2-isopropylmalate synthase/homocitrate synthase, post-catalytic domain

LeuA/HCS_post-cat

1

IPR054693

54,693

Sensor histidine protein kinase/phosphatase WalK-like, HAMP domain

WalK-like_HAMP

Domain

454

false

This domain is found at the N-terminal of sensor histidine protein kinase/phosphatase WalK from Streptococcus pneumoniae, the histidine kinase SMU_1516 from Streptococcus mutans (CovS, ) and similar proteins mainly found in Lactobacillales. WalK functions as a sensor protein kinase which is autophosphorylated at a hist...

[]

0

[ "PFAM" ]

[ "PF22610" ]

[ "CovS-like_HAMP" ]

[ 454 ]

1

[]

0

[ "4i5s" ]

1

[ "PUB00056536", "PUB00059470", "PUB00153881", "PUB00153882", "PUB00153883", "PUB00153884", "PUB00154837", "PUB00154838", "PUB00154839" ]

[ "21397188", "22244755", "23468592", "24680785", "24568954", "24681325", "20190050", "23013245", "27902439" ]

[ "The mechanisms of HAMP-mediated signaling in transmembrane receptors.", "Mechanism of regulation of receptor histidine kinases.", "Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains.", "Axial helix rotation as a mechanism for signal regulati...

[ 2011, 2012, 2013, 2014, 2014, 2014, 2010, 2012, 2017 ]

9

[ "IPR003660" ]

[]

1

0

1

[ "Bacteria" ]

[ 454 ]

1

[]

0

true

Domain

Sensor histidine protein kinase/phosphatase WalK-like, HAMP domain

WalK-like_HAMP

9

IPR054694

54,694

E3 ubiquitin-protein ligase parkin-like, IBR domain

Parkin-like_IBR

Domain

3,943

false

This entry represents an IBR (In Between Ring fingers) domain found in human E3 ubiquitin-protein ligase parkin and similar eukaryotic proteins. Parkin functions within a multiprotein E3 ubiquitin ligase complex, catalysing the covalent attachment of ubiquitin moieties onto substrate protein [ , , , , ]. This domain oc...

[]

0

[ "PFAM" ]

[ "PF22605" ]

[ "IBR_2" ]

[ 3943 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.3.2.31", "R-DDI-5675482", "R-DDI-5689877", "R-DDI-9646399", "R-DDI-983168", "R-DME-5205685", "R-DME-5689877", "R-DME-9646399", "R-DME-983168", "R-HSA-5205685", "R-HSA-5675482", "R-HSA-5689877", "R-HSA-9646399", "R-HSA-977225", "R-HSA-983168", "R-MMU-5205685", "R-MMU-5675482", "R...

[ "EC:2.3.2.31", "REACTOME:R-DDI-5675482", "REACTOME:R-DDI-5689877", "REACTOME:R-DDI-9646399", "REACTOME:R-DDI-983168", "REACTOME:R-DME-5205685", "REACTOME:R-DME-5689877", "REACTOME:R-DME-9646399", "REACTOME:R-DME-983168", "REACTOME:R-HSA-5205685", "REACTOME:R-HSA-5675482", "REACTOME:R-HSA-56898...

25

[ "1wd2", "2lwr", "2m48", "2m9y", "4bm9", "4i1f", "4i1h", "4k7d", "4k95", "4zyn", "5c1z", "5c23", "5c9v", "5caw", "5n2w", "5n38", "6djx", "6hue", "6n13", "8ik6", "8ikv", "8jwv", "8wzn", "8wzo", "9c5e" ]

25

[ "PUB00032241", "PUB00103494", "PUB00108941", "PUB00154021", "PUB00154840", "PUB00154841", "PUB00154842" ]

[ "15236971", "23754282", "23620051", "23770917", "22396657", "29311685", "32047033" ]

[ "Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING.", "Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.", "PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochond...

[ 2004, 2013, 2013, 2013, 2012, 2018, 2020 ]

7

[]

0

null

[ "Eukaryota", "Klosneuvirinae", "Parendozoicomonas haliclonae", "viral metagenome" ]

[ 3935, 3, 1, 4 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 2, 1, 8, 2, 1, 3, 21, 7 ]

9

true

Domain

E3 ubiquitin-protein ligase parkin-like, IBR domain

Parkin-like_IBR

5

IPR054695

54,695

Pierisin-like domain

Pierisin-like_dom

Domain

1,125

false

This entry represents a domain found in a group of ADP-ribosyltransferases from bacteria and eukaryota, including Pierisin from the butterfly Pieris rapae [ , ] and the smaller protein scabin ( ), a novel DNA-targeting enzyme from the plant pathogen Streptomyces scabiei [ , ].

[]

0

[ "PFAM" ]

[ "PF22596" ]

[ "Scabin-like" ]

[ 1125 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.4.2.-", "PWY-5381", "PWY-5800", "PWY-6148", "PWY-6720", "PWY-7018", "PWY-7025", "PWY-7450", "PWY-7817", "PWY-7981" ]

[ "EC:2.4.2.-", "METACYC:PWY-5381", "METACYC:PWY-5800", "METACYC:PWY-6148", "METACYC:PWY-6720", "METACYC:PWY-7018", "METACYC:PWY-7025", "METACYC:PWY-7450", "METACYC:PWY-7817", "METACYC:PWY-7981" ]

10

[ "2cb4", "2cb6", "2vsa", "2vse", "5daz", "5ewk", "5ewy", "5h6j", "5h6k", "5h6l", "5h6m", "5h6n", "5tlb", "5uvq", "5zj4", "5zj5", "6apy", "6vpa", "6vuv", "6vv4", "6vvf", "8s2m", "8s2n", "9gco" ]

24

[ "PUB00154224", "PUB00154225", "PUB00154843", "PUB00154844" ]

[ "27002155", "33450958", "10485873", "28765284" ]

[ "Scabin, a Novel DNA-acting ADP-ribosyltransferase from Streptomyces scabies.", "Mapping the DNA-Binding Motif of Scabin Toxin, a Guanine Modifying Enzyme from Streptomyces scabies.", "Molecular cloning of an apoptosis-inducing protein, pierisin, from cabbage butterfly: possible involvement of ADP-ribosy...

[ 2016, 2021, 1999, 2017 ]

4

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "hydrothermal vent metagenome" ]

[ 822, 4, 298, 1 ]

4

[]

0

true

Domain

Pierisin-like domain

Pierisin-like_dom

7

IPR054696

54,696

GTP-eEF1A, C-terminal domain

GTP-eEF1A_C

Domain

77,830

false

This entry represents a β-barrel domain that is found C-terminal in Elongation factor 1-alpha (eEF1A) and similar proteins from all cellular organisms. eEF1A promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis [ , ].

[]

0

[ "PFAM" ]

[ "PF22594" ]

[ "GTP-eEF1A_C" ]

[ 77830 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156842", "R-BTA-3371511", "R-BTA-6798695", "R-BTA-8876725", "R-CEL-3371511", "R-CEL-6798695", "R-CEL-8876725", "R-DDI-156842", "R-DDI-3371511", "R-DDI-6798695", "R-DDI-72764", "R-DDI-8876725", "R-DDI-975956", "R-DDI-975957", "R-DME-156842", "R-DME-3371511", "R-DME-429958", "...

[ "REACTOME:R-BTA-156842", "REACTOME:R-BTA-3371511", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8876725", "REACTOME:R-CEL-3371511", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-8876725", "REACTOME:R-DDI-156842", "REACTOME:R-DDI-3371511", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-72764", "REACTOME:R-...

62

[ "1f60", "1g7c", "1ije", "1ijf", "1jny", "1r5b", "1r5n", "1r5o", "1skq", "1zun", "2b7b", "2b7c", "3e1y", "3e20", "3izq", "3j5y", "3mca", "3p26", "3p27", "3vmf", "3wxm", "3wy9", "3wya", "4c0s", "4crn", "4cxg", "4cxh", "4d61", "5hxb", "5lzs", "5lzt", "5lzw"...

57

[ "PUB00039545", "PUB00154845" ]

[ "16675455", "28801462" ]

[ "Mg2+ and a key lysine modulate exchange activity of eukaryotic translation elongation factor 1B alpha.", "Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A." ]

[ 2006, 2017 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1079, 17190, 59251, 17, 293 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 35, 5, 24, 9, 1, 72, 17, 3, 23, 28, 3, 5, 110 ]

13

true

Domain

GTP-eEF1A, C-terminal domain

GTP-eEF1A_C

5

IPR054697

54,697

Nuclear pore complex interacting protein, N-terminal

NPIP_N

Domain

901

false

This entry includes a series of nuclear pore complex-interacting protein (NPIP) sequences from vertebrates. This entry represents helical segments that in some members constitute almost the full length of the sequence, while in others they are found at the N-terminal. In those cases, they are associated to a β-solenoid...

[]

0

[ "PFAM" ]

[ "PF06409" ]

[ "NPIP" ]

[ 901 ]

1

[ "REACTOME" ]

[ "R-HSA-9692916" ]

[ "REACTOME:R-HSA-9692916" ]

1

[]

0

[ "PUB00012374", "PUB00152230", "PUB00152231", "PUB00152232", "PUB00152233" ]

[ "11586358", "19717539", "18055785", "22405323", "11948212" ]

[ "Positive selection of a gene family during the emergence of humans and African apes.", "The evolution of human segmental duplications and the core duplicon hypothesis.", "Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.", "New and novel intrinsic host repressiv...

[ 2001, 2009, 2007, 2012, 2001 ]

5

[]

0

null

[ "Bilateria", "Enterobacter hormaechei" ]

[ 900, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 139, 1, 2 ]

3

true

Domain

Nuclear pore complex interacting protein, N-terminal

NPIP_N

8

IPR054698

54,698

Radical SAM (seleno)protein TrsS

rSAM_Se_TrsS

Family

308

false

This family represents TrsS (Third Radical SAM Selenoprotein) which joins two others radical SAM enzyme families of selenocysteine-containing family members. The other two are the arsenosugar biosynthesis radical SAM protein ArsS ( ) and the CUAEP/CCAEP-tail radical SAM protein family. In all three cases, the Sec resid...

[]

0

[ "NCBIFAM" ]

[ "NF045646" ]

[ "rSAM_Se_TrsS" ]

[ 308 ]

1

[]

0

[]

0

[]

0

[ "IPR034474" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriati", "ecological metagenomes" ]

[ 297, 5, 6 ]

3

[]

0

true

Family

Radical SAM (seleno)protein TrsS

rSAM_Se_TrsS

2

IPR054699

54,699

CUAEP/CCAEP-tail radical SAM protein

rSAM_CUAEP

Family

91

false

Members of this family are radical SAM enzymes with an N-terminal apparent B12-binding domain. Some members of the family have Cys-Cys motif about 10 amino acids before the C-terminal, but the majority of the family are selenoproteins with the second Cys replaced by selenocysteine, in a strongly conserved motif W[YF]C[...

[]

0

[ "NCBIFAM" ]

[ "NF040546" ]

[ "rSAM_CUAEP" ]

[ 91 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Marine Group III euryarchaeote", "unclassified sequences" ]

[ 77, 1, 13 ]

3

[]

0

true

Family

CUAEP/CCAEP-tail radical SAM protein

rSAM_CUAEP

4

IPR054700

54,700

Methanethiol S-methyltransferase

MddA

Family

875

false

This family includes methanethiol S-methyltransferases which catalyse the methylation of methanethiol (MeSH) to yield dimethylsulphide (DMS) [ ].

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF045656" ]

[ "MeththiolMtaseMddA" ]

[ 875 ]

1

[ "EC", "METACYC" ]

[ "2.1.1.334", "PWY-7793" ]

[ "EC:2.1.1.334", "METACYC:PWY-7793" ]

2

[]

0

[ "PUB00089624" ]

[ "25807229" ]

[ "A novel pathway producing dimethylsulphide in bacteria is widespread in soil environments." ]

[ 2015 ]

1

[ "IPR033580" ]

[]

1

0

1

[ "Bacteria", "Symbiodinium necroappetens", "ecological metagenomes" ]

[ 872, 1, 2 ]

3

[]

0

true

Family

Methanethiol S-methyltransferase

MddA

5

IPR054701

54,701

DVU0298-like

Family

355

false

Members of this family occur primarily in sulfate-reducing bacteria. They contain a HEAT repeat-region. DVU0298 ( ) was identified as candidate protein for involvement in carbon monoxide utilization as an electron donor during sulfate reduction [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045662" ]

[ "DVU0298_fam" ]

[ 355 ]

1

[]

0

[]

0

[ "PUB00154660" ]

[ "20628586" ]

[ "Carbon monoxide as an electron donor for the biological reduction of sulphate." ]

[ 2010 ]

1

[]

0

null

[ "Archaeoglobaceae", "Bacteria", "ecological metagenomes" ]

[ 9, 335, 11 ]

3

[]

0

true

Family

DVU0298-like

8

IPR054703

54,703

Molybdopterin-dependent aldehyde oxidoreductase-related

Mop-rel

Family

246

false

This entry represents a family of bacterial proteins that occur regularly in the context of a molybdopterin-dependent aldehyde oxidoreductase ( ). The N-terminal 200 amino acids are homologous to the molybdenum cofactor cytidylyltransferase MocA of Escherichia coli. The C-terminal 170 amino acid region contains an HDIG...

[]

0

[ "NCBIFAM" ]

[ "NF045665" ]

[ "NTPtran_DVU1551" ]

[ 246 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 242, 4 ]

2

[]

0

true

Family

Molybdopterin-dependent aldehyde oxidoreductase-related

Mop-rel

4

IPR054705

54,705

Molybdopterin-dependent aldehyde oxidoreductase

Mop

Family

366

false

Members of this family are molybdopterin-dependent enzymes that perform oxidative hydroxylation of aldehydes. Members are encoded in an eight-gene context that includes a radical SAM enzyme we designate TrsS, as it is the Third Radical SAM (Seleno)protein family discovered to have at least some members encoded with a s...

[]

0

[ "NCBIFAM" ]

[ "NF045668" ]

[ "pterin_aldehy" ]

[ 366 ]

1

[]

0

[ "1dgj", "1sij", "1vlb", "3fah", "3fc4", "3l4p", "4c7y", "4c7z", "4c80", "4us8", "4us9", "4usa" ]

12

[ "PUB00021399", "PUB00154723", "PUB00154724", "PUB00154725", "PUB00154726", "PUB00154727" ]

[ "10704312", "29030620", "25344343", "30451902", "24391748", "25536080" ]

[ "Gene sequence and crystal structure of the aldehyde oxidoreductase from Desulfovibrio desulfuricans ATCC 27774.", "Transcriptomic profiles of Clostridium ljungdahlii during lithotrophic growth with syngas or H2 and CO2 compared to organotrophic growth with fructose.", "Isotropic exchange ...

[ 2000, 2017, 2015, 2018, 2013, 2014 ]

6

[ "IPR016208" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 362, 4 ]

2

[]

0

true

Family

Molybdopterin-dependent aldehyde oxidoreductase

Mop

2