LiteFold/InterPro · Datasets at Hugging Face

IPR058514

58,514

Domain of unknown function DUF8201

DUF8201

Domain

673

false

This entry represents uncharacterised bacterial proteins. These proteins are highly hydrophobic and contain a conserved DxxxY sequence motif. Some proteins have a sequence similarity to members of the Glycosyl transferase GT-C superfamily and are predicted to fold into similar structures, suggesting they may be glycosy...

[]

0

[ "PFAM" ]

[ "PF26626" ]

[ "DUF8201" ]

[ 673 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanomicrobia", "ecological metagenomes" ]

[ 653, 4, 16 ]

3

[]

0

true

Domain

Domain of unknown function DUF8201

DUF8201

3

IPR058515

58,515

Domain of unknown function DUF8202

DUF8202

Domain

1,174

false

This entry represents a domain found in uncharacterised bacterial proteins. This domain is found in one or multiple copies and in combination with , and others. It has a significant structural similarity to known ZU5 and Gain domains suggesting it may be involved in adhesion.

[]

0

[ "PFAM" ]

[ "PF26628" ]

[ "DUF8202" ]

[ 1174 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 1164, 3, 7 ]

3

[]

0

true

Domain

Domain of unknown function DUF8202

DUF8202

2

IPR058516

58,516

Domain of unknown function DUF8203

DUF8203

Domain

19

false

This entry represents a domain found in a family of uncharacterised halobacterial species. The predicted structure shows structural similarity to ribonuclease HII suggesting it may act as a nuclease enzyme.

[]

0

[ "PFAM" ]

[ "PF26630" ]

[ "DUF8203" ]

[ 19 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 19 ]

1

[]

0

true

Domain

Domain of unknown function DUF8203

DUF8203

4

IPR058517

58,517

Domain of unknown function DUF8204

DUF8204

Domain

970

false

This domain is found in uncharacterised plant proteins. It is predicted to fold into an open barrel-like structure. It contains two pair of conserved cysteine residues which are predicted to form disulfide bonds. It may be involve in oligomerisation given the number of conserved exposed hydrophobic residues.

[]

0

[ "PFAM" ]

[ "PF26631" ]

[ "DUF8204" ]

[ 970 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 970 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 8, 12 ]

3

true

Domain

Domain of unknown function DUF8204

DUF8204

6

IPR058518

58,518

Domain of unknown function DUF8205

DUF8205

Domain

326

false

This domain is found in uncharacterised fungal proteins. It is probably distantly related to CcmS and and it is predicted to adopt topologically similar structure. It is found frequently in combination with and in multiple copies.

[]

0

[ "PFAM" ]

[ "PF26632" ]

[ "DUF8205" ]

[ 326 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Agaricomycetes" ]

[ 326 ]

1

[]

0

true

Domain

Domain of unknown function DUF8205

DUF8205

9

IPR058519

58,519

Domain of unknown function DUF8206

DUF8206

Domain

1,185

false

This domain is found in uncharacterised eukaryotic proteins. It contains a number of highly conserved cysteine and histidine residues that may be involved in metal coordination. Some proteins contain two copies of this domain. It probably adopt a novel fold judging by its predicted structure.

[]

0

[ "PFAM" ]

[ "PF26633" ]

[ "DUF8206" ]

[ 1185 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1185 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF8206

DUF8206

3

IPR058520

58,520

Domain of unknown function DUF8207

DUF8207

Domain

1,007

false

This domain is found in uncharacterised metazoan protein. It is predicted to adopt an α/β structure composed of curved β-sheet and α-helices packed on it.

[]

0

[ "PFAM" ]

[ "PF26634" ]

[ "DUF8207" ]

[ 1007 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta", "Viruses" ]

[ 1004, 3 ]

2

[]

0

true

Domain

Domain of unknown function DUF8207

DUF8207

9

IPR058521

58,521

Domain of unknown function DUF8208

DUF8208

Domain

873

false

This entry represents the N-terminal domain in large, membrane-embedded proteins of mobile elements such as the Bacillus subtilis natto plasmid pLS20. It is predicted to contain five transmembrane α-helices.

[]

0

[ "PFAM" ]

[ "PF26635" ]

[ "DUF8208" ]

[ 873 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 871, 2 ]

2

[]

0

true

Domain

Domain of unknown function DUF8208

DUF8208

5

IPR058522

58,522

Protein of unknown function DUF8209

DUF8209

Family

1,459

false

This entry represents uncharacterised proteins found in gamma- and beta-proteobacteria. A member of this family, STM2901, is a putative cytoplasmic protein from many but not all forms of SPI-1 (Salmonella Pathogenicity Island 1).

[]

0

[ "PFAM" ]

[ "PF26636" ]

[ "DUF8209" ]

[ 1459 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Erwinia phage EtG", "Pseudomonadati" ]

[ 1, 1458 ]

2

[]

0

true

Family

Protein of unknown function DUF8209

DUF8209

5

IPR058524

58,524

Domain of unknown function DUF8211

DUF8211

Domain

744

false

This domain is found in uncharacterised fungal proteins. It is predicted to fold into unusual α/β structure composed of a four-stranded antiparallel β-sheet capped with α-helices.

[]

0

[ "PFAM" ]

[ "PF26638" ]

[ "DUF8211" ]

[ 744 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Glomeraceae" ]

[ 744 ]

1

[]

0

true

Domain

Domain of unknown function DUF8211

DUF8211

4

IPR058525

58,525

Domain of unknown function DUF8212

DUF8212

Domain

7,027

false

This domain is found in uncharacterised proteins mainly from fungi. It is found frequently C-terminal to Het and it is predicted to fold into a β-barrel structure similar to Het-6 β-barrel domain.

[]

0

[ "PFAM" ]

[ "PF26640" ]

[ "DUF8212" ]

[ 7027 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dikarya" ]

[ 7027 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

Domain of unknown function DUF8212

DUF8212

5

IPR058526

58,526

Domain of unknown function DUF8213

DUF8213

Domain

394

false

This domain is found in uncharacterised proteins mainly from filamentous fungi. It contains ten highly conserved cysteine residues which are predicted to form disulfide bonds.

[]

0

[ "PFAM" ]

[ "PF26641" ]

[ "DUF8213" ]

[ 394 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 39, 355 ]

2

[]

0

true

Domain

Domain of unknown function DUF8213

DUF8213

8

IPR058527

58,527

Domain of unknown function DUF8214

DUF8214

Domain

29

false

This domain is found in uncharacterised proteins mainly from Agaricomycetes. It is probably distantly related to chaperone protein CcmS, and it is predicted to adopt topologically similar structure. It is found frequently in combination with .

[]

0

[ "PFAM" ]

[ "PF26646" ]

[ "DUF8214" ]

[ 29 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Agaricomycetes" ]

[ 29 ]

1

[]

0

true

Domain

Domain of unknown function DUF8214

DUF8214

4

IPR058528

58,528

Domain of unknown function DUF8215

DUF8215

Domain

170

false

This entry represents a domain from a family of uncharacterised proteins in the class Halobacteria. The proteins containing this domain are predominantly found in various genera within the Halobacteriales order. The domain is typically found in proteins ranging from 129 to 225 amino acids in length. These proteins are ...

[]

0

[ "PFAM" ]

[ "PF26650" ]

[ "DUF8215" ]

[ 170 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 170 ]

1

[]

0

true

Domain

Domain of unknown function DUF8215

DUF8215

1

IPR058529

58,529

Domain of unknown function DUF8216

DUF8216

Domain

16

false

This entry represents a domain from a family of uncharacterised proteins in archaea, specifically within the Halobacteria class. The proteins in this family are typically around 116 amino acids in length. They are predicted to be integral membrane proteins, as suggested by the presence of four predicted transmembrane h...

[]

0

[ "PFAM" ]

[ "PF26651" ]

[ "DUF8216" ]

[ 16 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 16 ]

1

[]

0

true

Domain

Domain of unknown function DUF8216

DUF8216

6

IPR058530

58,530

Baseplate J-like, C-terminal domain

Baseplate_J-like_C

Domain

7,883

false

This entry represents a C-terminal domain found in the P2 bacteriophage J protein, which lies at the edge of the baseplate [ , ], in the Baseplate protein gp47 from Escherichia phage Mu [ ] and similar sequences from tailed bacteriophages. This group also includes a number of bacterial homologues, which are thought to ...

[]

0

[ "PFAM" ]

[ "PF26079" ]

[ "Baseplate_J_C" ]

[ 7883 ]

1

[]

0

[ "5ces", "6u5b", "6u5k", "8v3w", "8v41", "8v43", "9g8s", "9gb2", "9ki1" ]

9

[ "PUB00008577", "PUB00161589", "PUB00161590", "PUB00161591" ]

[ "7483254", "22297511", "32350467", "39992138" ]

[ "Bacteriophage P2: genes involved in baseplate assembly.", "Contractile tail machines of bacteriophages.", "Action of a minimal contractile bactericidal nanomachine.", "In situ structures of the contractile nanomachine myophage Mu in both its extended and contracted states." ]

[ 1995, 2012, 2020, 2025 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 13, 7522, 12, 303, 33 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Baseplate J-like, C-terminal domain

Baseplate_J-like_C

4

IPR058531

58,531

Baseplate J-like, central domain

Baseplate_J_M

Domain

9,111

false

This entry represents a domain found centrally in the P2 bacteriophage J protein, which lies at the edge of the baseplate [ , ], in the Baseplate protein gp47 from Escherichia phage Mu [ ] and similar sequences from tailed bacteriophages. This group also includes a number of bacterial homologues, which are thought to h...

[]

0

[ "PFAM" ]

[ "PF26078" ]

[ "Baseplate_J_M" ]

[ 9111 ]

1

[]

0

[ "6u5b", "6u5k", "8v3w", "8v41", "8v43", "9g8s", "9gb2", "9ki1" ]

8

[ "PUB00008577", "PUB00161589", "PUB00161590", "PUB00161591" ]

[ "7483254", "22297511", "32350467", "39992138" ]

[ "Bacteriophage P2: genes involved in baseplate assembly.", "Contractile tail machines of bacteriophages.", "Action of a minimal contractile bactericidal nanomachine.", "In situ structures of the contractile nanomachine myophage Mu in both its extended and contracted states." ]

[ 1995, 2012, 2020, 2025 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanolapillus millepedarum", "Viruses", "metagenomes" ]

[ 8719, 24, 1, 339, 28 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Baseplate J-like, central domain

Baseplate_J_M

8

IPR058532

58,532

YjbR/MT2646/Rv2570-like

Family

22,656

false

This entry represents uncharacterised bacterial proteins including YjbR from Escherichia coli, Rv2570 and MT2646 from Mycobacterium tuberculosis. YjbR protein has been predicted to adopt a CyaY-like fold [ ].

[]

0

[ "PFAM" ]

[ "PF04237" ]

[ "YjbR" ]

[ 22656 ]

1

[]

0

[ "2a1v", "2fki", "2kfp", "3h9x" ]

4

[ "PUB00066658" ]

[ "23044854" ]

[ "Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing." ]

[ 2012 ]

1

[]

[ "IPR007351" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 22489, 16, 13, 138 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

YjbR/MT2646/Rv2570-like

8

IPR058533

58,533

Cation efflux protein, transmembrane domain

Cation_efflux_TM

Domain

108,072

false

This entry represents the transmembrane domain at the N-terminal in Cattion efflux proteins. Cation Diffusion Facilitator (CDF) transporter proteins, including SLC30A, which is involved in zinc transport, and FieF, which is associated with metal detoxification are involved in the transport of divalent metal cations acr...

[]

0

[ "PFAM" ]

[ "PF01545" ]

[ "Cation_efflux" ]

[ 108072 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-425410", "R-CEL-435368", "R-DDI-264876", "R-DDI-425410", "R-DDI-435368", "R-DRE-264876", "R-DRE-435368", "R-GGA-264876", "R-GGA-435368", "R-HSA-264876", "R-HSA-425410", "R-HSA-435368", "R-MMU-264876", "R-MMU-425410", "R-MMU-435368", "R-RNO-264876", "R-RNO-435368", "R-SCE-264...

[ "REACTOME:R-CEL-425410", "REACTOME:R-CEL-435368", "REACTOME:R-DDI-264876", "REACTOME:R-DDI-425410", "REACTOME:R-DDI-435368", "REACTOME:R-DRE-264876", "REACTOME:R-DRE-435368", "REACTOME:R-GGA-264876", "REACTOME:R-GGA-435368", "REACTOME:R-HSA-264876", "REACTOME:R-HSA-425410", "REACTOME:R-HSA-435...

25

[ "2qfi", "3h90", "3j1z", "5vrf", "6xpd", "6xpe", "6xpf", "7kzx", "7kzz", "7y5g", "7y5h", "8f6e", "8f6f", "8f6h", "8f6i", "8f6j", "8f6k", "8j2g", "8j7t", "8j7u", "8j7v", "8j7w", "8j7x", "8j7y", "8j80", "8xm6", "8xma", "8xmf", "8xmj", "8xn1", "8zb0", "8zsb"...

41

[ "PUB00000764", "PUB00002316" ]

[ "8829543", "9696746" ]

[ "Cloning and sequence analysis of czc genes in Alcaligenes sp. strain CT14.", "Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus." ]

[ 1996, 1998 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1736, 65768, 39674, 6, 888 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 61, 16, 27, 14, 2, 37, 35, 10, 21, 32, 5, 4, 67 ]

13

true

Domain

Cation efflux protein, transmembrane domain

Cation_efflux_TM

3

IPR058534

58,534

Inner membrane protein YjdF

YjdF

Family

3,197

false

This entry represents the Inner membrane protein YjdF and related bacterial proteins. Inner membrane protein YjdF is a protein found in Escherichia coli and is encoded by the yjdF gene. It is characterised as a conserved inner membrane protein with six predicted transmembrane domains, and its C-terminal is located in t...

[]

0

[ "PIRSF" ]

[ "PIRSF020606" ]

[ "UCP020606" ]

[ 3197 ]

1

[]

0

[]

0

[]

0

[ "IPR014509" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 3151, 17, 29 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane protein YjdF

YjdF

4

IPR058536

58,536

CFAP65, fourth Ig-like domain

Ig_CFAP65_4th

Domain

1,730

false

This entry represents the fourth Ig-like domain of CFAP65 and related sequences. Cilia-Flagella-Associated Protein 65 (CFAP65) is involved in the structural and functional integrity of cilia and flagella. This protein is implicated in the process of flagellar formation and is essential for proper sperm motility, sugges...

[]

0

[ "PFAM" ]

[ "PF24507" ]

[ "Ig_CFAP65_4th" ]

[ 1730 ]

1

[]

0

[ "7n61", "7som", "9ijj" ]

3

[ "PUB00155585", "PUB00160504" ]

[ "33472045", "22761584" ]

[ "Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.", "The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility." ]

[ 2021, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1730 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 4, 4, 3 ]

4

true

Domain

CFAP65, fourth Ig-like domain

Ig_CFAP65_4th

6

IPR058537

58,537

Transportin-3/Importin-13, fourth TPR domain

TPR_TNPO3_IPO13_4th

Repeat

6,668

false

This entry represents the third TPR domain found in Transportin-3 (TNPO3) from animals, as well as orthologues MTR10 and uncharacterised protein YNR7 from yeast and MOS14 from plants. This entry also includes Importin-13 (IPO3) from animals. This domain interacts with the RS region of the ASF protein for nuclear transp...

[]

0

[ "PFAM" ]

[ "PF24139" ]

[ "TPR_TNPO3_IPO13_4th" ]

[ 6668 ]

1

[]

0

[ "2x19", "2x1g", "2xwu", "3zjy", "3zkv", "4c0o", "4c0p", "4c0q", "4ol0", "6gx9", "8cmk" ]

11

[ "PUB00130144", "PUB00155879" ]

[ "12628928", "24449914" ]

[ "A novel splicing regulator shares a nuclear import pathway with SR proteins.", "Structural basis for nuclear import of splicing factors by human Transportin 3." ]

[ 2003, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 6668 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 4, 2, 8, 6, 1, 4, 17, 1, 1, 21 ]

12

true

Repeat

Transportin-3/Importin-13, fourth TPR domain

TPR_TNPO3_IPO13_4th

2

IPR058538

58,538

TPPC8, second Ig-like domain

Ig_TPPC8_2nd

Domain

2,566

false

This entry represents the second Ig-like domain found in the middle region of TPPC8. TPPC8 plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage [ ]. Together with TBC1D14, it maintains the cycling pool of ATG9 required for initiation of autophagy [ ]. It is one of the TRAPPIII comp...

[]

0

[ "PFAM" ]

[ "PF24544" ]

[ "Ig_TPPC8_2nd" ]

[ 2566 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-CEL-8876198", "R-HSA-8876198" ]

[ "REACTOME:R-CEL-8876198", "REACTOME:R-HSA-8876198" ]

2

[]

0

[ "PUB00075414", "PUB00155679" ]

[ "21525244", "26711178" ]

[ "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.", "TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic." ]

[ 2011, 2016 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2566 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 5, 3, 3, 4, 4 ]

7

true

Domain

TPPC8, second Ig-like domain

Ig_TPPC8_2nd

6

IPR058540

58,540

TPPC8, third Ig-like domain

Ig_TPPC8_3rd

Domain

1,933

false

This entry represents the third Ig-like domain found in the middle region of TPPC8. TPPC8 plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage [ ]. Together with TBC1D14, it maintains the cycling pool of ATG9 required for initiation of autophagy [ ]. It is one of the TRAPPIII compl...

[]

0

[ "PFAM" ]

[ "PF24546" ]

[ "Ig_TPPC8_3rd" ]

[ 1933 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-CEL-8876198", "R-HSA-8876198" ]

[ "REACTOME:R-CEL-8876198", "REACTOME:R-HSA-8876198" ]

2

[]

0

[ "PUB00075414", "PUB00155679" ]

[ "21525244", "26711178" ]

[ "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.", "TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic." ]

[ 2011, 2016 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1933 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 3, 3, 5, 4 ]

6

true

Domain

TPPC8, third Ig-like domain

Ig_TPPC8_3rd

6

IPR058541

58,541

TPPC8, first Ig-like domain

Ig_TPPC8_1st

Domain

3,336

false

This entry represents the first Ig-like domain found in the middle region of TPPC8. TPPC8 plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage [ ]. Together with TBC1D14, it maintains the cycling pool of ATG9 required for initiation of autophagy [ ]. It is one of the TRAPPIII compl...

[]

0

[ "PFAM" ]

[ "PF24545" ]

[ "Ig_TPPC8_1st" ]

[ 3336 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-CEL-8876198", "R-HSA-8876198" ]

[ "REACTOME:R-CEL-8876198", "REACTOME:R-HSA-8876198" ]

2

[]

0

[ "PUB00075414", "PUB00155679" ]

[ "21525244", "26711178" ]

[ "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.", "TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic." ]

[ 2011, 2016 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3336 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 2, 5, 3, 4, 6, 5, 4, 3 ]

9

true

Domain

TPPC8, first Ig-like domain

Ig_TPPC8_1st

3

IPR058542

58,542

SCN5A-like, C-terminal IQ motif

IQ_SCN5A_C

Domain

15,352

false

This entry represents the IQ motif of SCN5A, a key element in the calcium sensing apparatus [ ]. Human Sodium channel protein type 5 subunit alpha (SCN5A) mediates the voltage-dependent sodium ion permeability of excitable membranes. Its C-terminal domain is organised into two regions: an IQ motif and an EF-hand domain...

[]

0

[ "PFAM" ]

[ "PF24609" ]

[ "IQ_SCN5A_C" ]

[ 15352 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-445095", "R-HSA-5576892", "R-HSA-9717207" ]

[ "REACTOME:R-HSA-445095", "REACTOME:R-HSA-5576892", "REACTOME:R-HSA-9717207" ]

3

[ "2kxw", "2l53", "2m5e", "4dck", "4jpz", "4jq0", "4ovn", "5xsy", "6agf", "6but", "6j8e", "6j8g", "6j8h", "6j8i", "6j8j", "6lqa", "6mba", "6mc9", "6mud", "6mue", "7dtc", "7dtd", "7tj8", "7tj9", "7w77", "7w7f", "7w9k", "7w9l", "7w9m", "7w9p", "7w9t", "7we4"...

66

[ "PUB00054635", "PUB00061181", "PUB00155684", "PUB00155685", "PUB00155686", "PUB00155687" ]

[ "21167176", "22705208", "21439835", "25232683", "33770503", "25370050" ]

[ "Solution NMR Structure of Apo-Calmodulin in Complex with the IQ Motif of Human Cardiac Sodium Channel NaV1.5.", "Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin.", "Structural and energetic determinants of apo calmodulin binding ...

[ 2011, 2012, 2011, 2014, 2021, 2014 ]

6

[]

0

null

[ "Eukaryota" ]

[ 15352 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 39, 51, 39, 47, 52 ]

5

true

Domain

SCN5A-like, C-terminal IQ motif

IQ_SCN5A_C

4

IPR058543

58,543

RSE1/DDB1/CPSF1, second beta-propeller

Beta-prop_RSE1/DDB1/CPSF1_2nd

Domain

15,850

false

This entry represents the second β-propeller found in RSE1/SF3B3/ DDB1/CPSF1/CFT1 proteins in eukaryotes. RSE1/SF3B3/DDB1/CPSF1/CFT1 proteins share a domain architecture consisting of three β-propellers. They have diverse functions, primarily related to RNA/DNA binding. Pre-mRNA-splicing factor RSE1 plays an important ...

[]

0

[ "PFAM" ]

[ "PF23726" ]

[ "Beta-prop_RSE1_2nd" ]

[ 15850 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-72163", "R-BTA-72165", "R-CEL-110314", "R-CEL-5696394", "R-CEL-5696395", "R-CEL-5696400", "R-CEL-6781823", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-72187", "R-CEL-72203", "R-CEL-73856", "R-CEL-77595", "R-CEL-8951664", "R-DDI-110314", "R-DDI-5696394", "R-DDI-5696395", "R-DDI-...

[ "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72165", "REACTOME:R-CEL-110314", "REACTOME:R-CEL-5696394", "REACTOME:R-CEL-5696395", "REACTOME:R-CEL-5696400", "REACTOME:R-CEL-6781823", "REACTOME:R-CEL-6782135", "REACTOME:R-CEL-6782210", "REACTOME:R-CEL-72187", "REACTOME:R-CEL-72203", "REACTOME:R-CEL-7...

86

[ "2b5l", "2b5m", "2b5n", "2hye", "3e0c", "3ei1", "3ei2", "3ei3", "3ei4", "3i7h", "3i7k", "3i7l", "3i7n", "3i7o", "3i7p", "3i89", "3i8c", "3i8e", "4a08", "4a09", "4a0a", "4a0b", "4a0k", "4a0l", "4a11", "4ci1", "4ci2", "4ci3", "4e54", "4e5z", "4tz4", "5gm6"...

181

[ "PUB00007715", "PUB00155537", "PUB00155538", "PUB00155539", "PUB00155540", "PUB00155541" ]

[ "11421366", "9819400", "27185460", "16940174", "16407252", "8929410" ]

[ "The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo.", "A link between secretion and pre-mRNA processing defects in Saccharomyces cerevisiae and the identification of a novel splicing gene, RSE1.", "The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila ...

[ 2001, 1998, 2016, 2006, 2006, 1996 ]

6

[]

0

null

[ "Eukaryota", "Pseudomonadati", "bird metagenome" ]

[ 15845, 3, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 29, 4, 6, 4, 17, 9, 4, 11, 12, 2, 4, 71 ]

12

true

Domain

RSE1/DDB1/CPSF1, second beta-propeller

Beta-prop_RSE1/DDB1/CPSF1_2nd

1

IPR058544

58,544

Ethylene receptor 1-like, N-terminal domain

ETR1_N

Domain

4,957

false

This domain is found at the N-terminal end of Ethylene receptor 1 from Arabidopsis thaliana (ETR1) and similar plant proteins. This domain, which is predicted to adopt an all α structure, is often found associated to . ETR1 acts as a redundant negative regulator of ethylene signalling. It is related to bacterial two-co...

[]

0

[ "PFAM" ]

[ "PF25487" ]

[ "ETR1_N" ]

[ 4957 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[]

0

[ "PUB00076421", "PUB00161595" ]

[ "15703053", "15466228" ]

[ "Ethylene-binding activity, gene expression levels, and receptor system output for ethylene receptor family members from Arabidopsis and tomato.", "Requirement of the histidine kinase domain for signal transduction by the ethylene receptor ETR1." ]

[ 2005, 2004 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Mollyvirus", "ecological metagenomes" ]

[ 1629, 3323, 2, 3 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 110, 9, 33 ]

3

true

Domain

Ethylene receptor 1-like, N-terminal domain

ETR1_N

3

IPR058545

58,545

EMC1, first beta-propeller domain

Beta-prop_EMC1_1st

Domain

4,874

false

This entry represents the N-terminal β-propeller domain of EMC1. ER membrane protein complex subunit 1 (EMC1) is a component of the endoplasmic reticulum membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6) that enables the energy-independent insertion into endoplasmic reticulum membranes o...

[]

0

[ "PFAM" ]

[ "PF25293" ]

[ "Beta-prop_EMC1_N" ]

[ 4874 ]

1

[]

0

[ "6ww7", "7ado", "7adp", "8eoi", "8j0n", "8j0o", "8s9s", "9c7v" ]

8

[ "PUB00061987", "PUB00096678", "PUB00096681", "PUB00096682" ]

[ "19325107", "30415835", "32459176", "32439656" ]

[ "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.", "EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.", "The architecture of EMC reveals a path for membrane protein insertion.", "Structural basis for membrane insertion by the human ER membran...

[ 2009, 2018, 2020, 2020 ]

4

[]

0

null

[ "Armatimonas rosea", "Eukaryota" ]

[ 1, 4873 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 2, 2, 2, 9, 3, 1, 4, 4, 1, 17 ]

11

true

Domain

EMC1, first beta-propeller domain

Beta-prop_EMC1_1st

4

IPR058546

58,546

Disease resistance protein RPS4B/Roq1-like, leucine-rich repeats

RPS4B/Roq1-like_LRR

Domain

6,772

false

This entry represents a region of leucine-rich repeats found in Disease resistance protein RPS4B from Arabidopsis thaliana, Disease resistance protein Roq1 from Nicotiana benthamiana and similar proteins found in plants. RPS4B specifically recognises the AvrRps4 type III effector avirulence protein from P.syringae [ ]....

[]

0

[ "PFAM" ]

[ "PF23286" ]

[ "LRR_13" ]

[ 6772 ]

1

[ "EC", "METACYC" ]

[ "3.2.2.6", "PWY-5381" ]

[ "EC:3.2.2.6", "METACYC:PWY-5381" ]

2

[ "7jlu", "7jlv", "7jlx" ]

3

[ "PUB00097510", "PUB00098642", "PUB00098643", "PUB00147622", "PUB00155711", "PUB00155712", "PUB00161088" ]

[ "31439792", "33273071", "33273074", "25744164", "24114786", "31964818", "28891100" ]

[ "NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.", "Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.", "Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.", "Two linked pairs of Arabidop...

[ 2019, 2020, 2020, 2015, 2013, 2020, 2017 ]

7

[]

0

null

[ "Eukaryota" ]

[ 6772 ]

1

[ "Arabidopsis thaliana" ]

[ 100 ]

1

true

Domain

Disease resistance protein RPS4B/Roq1-like, leucine-rich repeats

RPS4B/Roq1-like_LRR

5

IPR058547

58,547

Pelota, N-terminal domain

Pelota_N

Domain

5,840

false

This entry represents the N-terminal domain found in Pelota proteins from eukaryotes and bacteria. Pelota (known as DOM34 in yeast) is a conserved protein in eukaryotes and archaea [ ] that binds Hbs1, a GTPase related to the EF1-alpha subfamily, and plays a central role in mRNA surveillance during protein synthesis [ ...

[]

0

[ "PFAM" ]

[ "PF26356" ]

[ "Pelota_N" ]

[ 5840 ]

1

[]

0

[ "2qi2", "2vgm", "2vgn", "3izq", "3j15", "3j16", "3mca", "3obw", "3oby", "3wxm", "5lzw", "5lzx", "5lzy", "5lzz", "5m1j", "6ji2" ]

16

[ "PUB00049007", "PUB00058728", "PUB00070080", "PUB00070081", "PUB00070083", "PUB00161397", "PUB00161398", "PUB00161399" ]

[ "17889667", "20682285", "21448132", "18022361", "20974926", "22358840", "20890290", "31611569" ]

[ "Structural and functional insights into Dom34, a key component of no-go mRNA decay.", "Crystal structures of two archaeal Pelotas reveal inter-domain structural plasticity.", "Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes.", "RNA quality control in ...

[ 2007, 2010, 2011, 2007, 2010, 2012, 2010, 2019 ]

8

[ "IPR005140" ]

[]

1

0

1

[ "Archaea", "Desulfofervidus auxilii", "Eukaryota", "Halorubrum virus BJ1", "ecological metagenomes" ]

[ 911, 1, 4892, 1, 35 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 1, 1, 2, 2, 1, 4, 1, 1, 1, 4 ]

12

true

Domain

Pelota, N-terminal domain

Pelota_N

8

IPR058549

58,549

Methylmalonyl-CoA mutase, alpha/beta chain, conserved site

MeMalonylCoA_mutase_a/b_site

Conserved_site

9,661

false

This entry represents the best conserved region which is located in the central part of the Methylmalonyl-CoA mutase. Methylmalonyl-CoA mutase ( ) (MCM) [ ] is an adenosylcobalamin (vitamin B12) dependent enzyme that catalyses the isomerization between methylmalonyl-CoA and succinyl-CoA. MCM is involved in various cata...

[]

0

[ "PROSITE" ]

[ "PS00544" ]

[ "METMALONYL_COA_MUTASE" ]

[ 9661 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.4.99.2", "PWY-5743", "PWY-5789", "PWY-6728", "PWY-7384", "PWY-7854", "PWY-8086", "R-CEL-71032", "R-CEL-9759218", "R-HSA-3359475", "R-HSA-3359478", "R-HSA-71032", "R-HSA-9759218", "R-MMU-71032", "R-MMU-9759218" ]

[ "EC:5.4.99.2", "METACYC:PWY-5743", "METACYC:PWY-5789", "METACYC:PWY-6728", "METACYC:PWY-7384", "METACYC:PWY-7854", "METACYC:PWY-8086", "REACTOME:R-CEL-71032", "REACTOME:R-CEL-9759218", "REACTOME:R-HSA-3359475", "REACTOME:R-HSA-3359478", "REACTOME:R-HSA-71032", "REACTOME:R-HSA-9759218", "RE...

15

[ "1e1c", "1req", "2req", "2xij", "2xiq", "3bic", "3req", "4req", "5req", "6oxc", "6oxd", "6req", "7req", "8dyj", "8dyl", "8gju" ]

16

[ "PUB00000715", "PUB00002563" ]

[ "1975493", "2197274" ]

[ "Perspectives on methylmalonic acidemia resulting from molecular cloning of methylmalonyl CoA mutase.", "Cloning, sequencing, and expression of the genes encoding the adenosylcobalamin-dependent ethanolamine ammonia-lyase of Salmonella typhimurium." ]

[ 1990, 1990 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes", "uncultured miscellaneous Crenarchaeota group" ]

[ 8057, 1539, 64, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 13, 2, 3 ]

6

true

Conserved_site

Methylmalonyl-CoA mutase, alpha/beta chain, conserved site

MeMalonylCoA_mutase_a/b_site

5

IPR058551

58,551

Plasmid partition protein, putative, C-terminal domain

Plasmid_parti_C

Domain

630

false

This entry represents the C-terminal domain of conserved hypothetical proteins from Borrelia burgdorferi, the Lyme disease spirochaete, and similar sequences from Borreliella and Borrelia species. Some members are putative plasmid partition proteins [ ].

[]

0

[ "PFAM" ]

[ "PF25882" ]

[ "Plasmid_parti_C" ]

[ 630 ]

1

[]

0

[]

0

[ "PUB00002297", "PUB00003601" ]

[ "8655548", "9695920" ]

[ "A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31.", "Evidence of past recombination events among the genes encoding the Erp antigens of Borrelia burgdorferi." ]

[ 1996, 1998 ]

2

[]

0

null

[ "Borreliaceae" ]

[ 630 ]

1

[]

0

true

Domain

Plasmid partition protein, putative, C-terminal domain

Plasmid_parti_C

1

IPR058552

58,552

V(D)J recombination-activating protein 1, DNA-binding domain

RAG1_DNA-bd

Domain

13,300

false

This entry represents the dimerisation and DNA-binding domain of RAG1 (V(D)J recombination-activating protein 1). The RAG complex, consisting of two RAG1 and two RAG2 proteins is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination [ ]. RAG1 mediates DNA-binding to ...

[]

0

[ "PFAM" ]

[ "PF26024" ]

[ "RAG1_DNA-bd" ]

[ 13300 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "3jbw", "3jbx", "3jby", "4wwx", "5zdz", "5ze0", "5ze1", "5ze2", "6b40", "6cg0", "6cij", "6cik", "6cil", "6cim", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq", "6oer", "6oes"...

42

[ "PUB00054210", "PUB00056079", "PUB00098031", "PUB00150929" ]

[ "8861909", "19621044", "24464998", "25707801" ]

[ "RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.", "RAG: a recombinase diversified.", "The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification.", "Crystal structure of the V(D)J recombinase RAG1-RAG2." ]

[ 1996, 2009, 2014, 2015 ]

4

[]

0

null

[ "Eumetazoa" ]

[ 13300 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 2, 2 ]

4

true

Domain

V(D)J recombination-activating protein 1, DNA-binding domain

RAG1_DNA-bd

4

IPR058553

58,553

V(D)J recombination-activating protein 1, pre-RNase H domain

RAG1_pre-RNase_H

Domain

25,344

false

This entry represents the pre-RNase H domain of RAG1 (V(D)J recombination-activating protein 1). The RAG complex, consisting of two RAG1 and two RAG2 proteins is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination [ ]. RAG1 mediates DNA-binding to the conserved rec...

[]

0

[ "PFAM" ]

[ "PF26025" ]

[ "RAG1_pre-RNase_H" ]

[ 25344 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "3jbw", "3jbx", "3jby", "4wwx", "5zdz", "5ze0", "5ze1", "5ze2", "6b40", "6cg0", "6cij", "6cik", "6cil", "6cim", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq", "6oer", "6oes"...

42

[ "PUB00054210", "PUB00056079", "PUB00098031", "PUB00150929" ]

[ "8861909", "19621044", "24464998", "25707801" ]

[ "RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.", "RAG: a recombinase diversified.", "The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification.", "Crystal structure of the V(D)J recombinase RAG1-RAG2." ]

[ 1996, 2009, 2014, 2015 ]

4

[]

0

null

[ "Eumetazoa" ]

[ 25344 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 2, 3 ]

4

true

Domain

V(D)J recombination-activating protein 1, pre-RNase H domain

RAG1_pre-RNase_H

6

IPR058554

58,554

V(D)J recombination-activating protein 1, RNase H domain

RAG1_RNase_H

Domain

30,320

false

This entry represents the catalytic RNase H domain of RAG1 (V(D)J recombination-activating protein 1). The RAG complex, consisting of two RAG1 and two RAG2 proteins is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination [ ]. RAG1 mediates DNA-binding to the conserv...

[]

0

[ "PFAM" ]

[ "PF26100" ]

[ "RAG1_RNase_H" ]

[ 30320 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "3jbw", "3jbx", "3jby", "4wwx", "5zdz", "5ze0", "5ze1", "5ze2", "6b40", "6cg0", "6cij", "6cik", "6cil", "6cim", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq", "6oer", "6oes"...

42

[ "PUB00054210", "PUB00056079", "PUB00098031", "PUB00150929" ]

[ "8861909", "19621044", "24464998", "25707801" ]

[ "RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.", "RAG: a recombinase diversified.", "The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification.", "Crystal structure of the V(D)J recombinase RAG1-RAG2." ]

[ 1996, 2009, 2014, 2015 ]

4

[]

0

null

[ "Metazoa" ]

[ 30320 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 4, 4, 6 ]

4

true

Domain

V(D)J recombination-activating protein 1, RNase H domain

RAG1_RNase_H

5

IPR058555

58,555

V(D)J recombination-activating protein 1, ZnC2 domain

RAG1_ZnC2

Domain

28,695

false

This entry represents the ZnC2 domain of RAG1(V(D)J recombination-activating protein 1). The RAG complex, consisting of two RAG1 and two RAG2 proteins is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination [ ]. RAG1 mediates DNA-binding to the conserved recombinati...

[]

0

[ "PFAM" ]

[ "PF26101" ]

[ "RAG1_ZnC2" ]

[ 28695 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "3jbw", "3jbx", "3jby", "4wwx", "5zdz", "5ze0", "5ze1", "5ze2", "6b40", "6cg0", "6cij", "6cik", "6cil", "6cim", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq", "6oer", "6oes"...

42

[ "PUB00054210", "PUB00056079", "PUB00056080", "PUB00098031", "PUB00150929" ]

[ "8861909", "19621044", "7642230", "24464998", "25707801" ]

[ "RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.", "RAG: a recombinase diversified.", "The recombination activation gene 1 (RAG1) of rainbow trout (Oncorhynchus mykiss): cloning, expression, and phylogenetic analysis.", "The RNase H-like superfamily: new members, comp...

[ 1996, 2009, 1995, 2014, 2015 ]

5

[]

0

null

[ "Eumetazoa" ]

[ 28695 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 4, 4, 6 ]

4

true

Domain

V(D)J recombination-activating protein 1, ZnC2 domain

RAG1_ZnC2

4

IPR058556

58,556

V(D)J recombination-activating protein 1, ZnH2 domain

RAG1_ZnH2

Domain

24,351

false

This entry represents the ZnH2 domain of RAG1 (V(D)J recombination-activating protein 1). The RAG complex, consisting of two RAG1 and two RAG2 proteins is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination [ ]. RAG1 mediates DNA-binding to the conserved recombinat...

[]

0

[ "PFAM" ]

[ "PF26104" ]

[ "RAG1_ZnH2" ]

[ 24351 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "3jbw", "3jbx", "3jby", "4wwx", "5zdz", "5ze0", "5ze1", "5ze2", "6b40", "6cg0", "6cij", "6cik", "6cil", "6cim", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq", "6oer", "6oes"...

42

[ "PUB00054210", "PUB00056079", "PUB00056080", "PUB00098031", "PUB00150929" ]

[ "8861909", "19621044", "7642230", "24464998", "25707801" ]

[ "RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.", "RAG: a recombinase diversified.", "The recombination activation gene 1 (RAG1) of rainbow trout (Oncorhynchus mykiss): cloning, expression, and phylogenetic analysis.", "The RNase H-like superfamily: new members, comp...

[ 1996, 2009, 1995, 2014, 2015 ]

5

[]

0

null

[ "Eumetazoa" ]

[ 24351 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 4, 5, 5 ]

4

true

Domain

V(D)J recombination-activating protein 1, ZnH2 domain

RAG1_ZnH2

3

IPR058557

58,557

V(D)J recombination-activating protein 1, C-terminal domain

RAG1_C

Domain

9,658

false

This entry represents the C-terminal domain of RAG1(V(D)J recombination-activating protein 1). The RAG complex, consisting of two RAG1 and two RAG2 proteins is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination [ ]. RAG1 mediates DNA-binding to the conserved recom...

[]

0

[ "PFAM" ]

[ "PF26105" ]

[ "RAG1_C" ]

[ 9658 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "3jbw", "3jbx", "3jby", "4wwx", "5zdz", "5ze0", "5ze1", "5ze2", "6b40", "6cg0", "6cij", "6cik", "6cil", "6cim", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq", "6oer", "6oes"...

42

[ "PUB00054210", "PUB00056079", "PUB00056080", "PUB00098031", "PUB00150929" ]

[ "8861909", "19621044", "7642230", "24464998", "25707801" ]

[ "RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.", "RAG: a recombinase diversified.", "The recombination activation gene 1 (RAG1) of rainbow trout (Oncorhynchus mykiss): cloning, expression, and phylogenetic analysis.", "The RNase H-like superfamily: new members, comp...

[ 1996, 2009, 1995, 2014, 2015 ]

5

[]

0

null

[ "Bilateria" ]

[ 9658 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 3, 3 ]

4

true

Domain

V(D)J recombination-activating protein 1, C-terminal domain

RAG1_C

9

IPR058558

58,558

V(D)J recombination-activating protein 1, RING finger, HC subclass

RING-HC_RAG1

Domain

13,109

false

This entry represents the N-terminal domain of RAG1(V(D)J recombination-activating protein 1). This domain consists of a C3HC4-type RING-HC finger. The RAG complex, consisting of two RAG1 and two RAG2 proteins is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination ...

[]

0

[ "CDD" ]

[ "cd16530" ]

[ "RING-HC_RAG1" ]

[ 13109 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1266695", "R-HSA-5687128" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1266695", "REACTOME:R-HSA-5687128" ]

4

[ "3jbw", "3jbx", "3jby", "6cg0", "6cij", "6dbi", "6dbj", "6dbl", "6dbo", "6dbq", "6dbr", "6dbt", "6dbu", "6dbv", "6dbw", "6dbx", "6oem", "6oen", "6oeo", "6oep", "6oeq", "6oer", "6oes", "6oet", "6v0v", "6xnx", "6xny", "6xnz", "9jpu", "9jpx", "9jqn", "9jts"...

33

[ "PUB00030727", "PUB00054210", "PUB00056079", "PUB00098031", "PUB00138007", "PUB00138010", "PUB00138011", "PUB00138016", "PUB00150929" ]

[ "9228952", "8861909", "19621044", "24464998", "2598259", "9630231", "10606976", "20122409", "25707801" ]

[ "Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.", "RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination.", "RAG: a recombinase diversified.", "The RNase H-like superfamily: new members, compar...

[ 1997, 1996, 2009, 2014, 1989, 1998, 2000, 2010, 2015 ]

9

[ "IPR018957" ]

[]

1

0

1

[ "Bilateria" ]

[ 13109 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 3, 3 ]

4

true

Domain

V(D)J recombination-activating protein 1, RING finger, HC subclass

RING-HC_RAG1

1

IPR058559

58,559

STIL, proline-rich motif

PRM_STIL

Conserved_site

1,087

false

This proline-rich region is found in STIL. This motif is involved in the CPAP TCP domain binding [ ]. This entry is specific to vertebrates. SIL (also called STIL/TAL1 interrupting locus) is an immediate-early gene that is essential for embryonic development and is implicated in T-cell leukemia-associated translocation...

[]

0

[ "PFAM" ]

[ "PF26399" ]

[ "PRM_STIL" ]

[ 1087 ]

1

[]

0

[ "4bxr", "4ld3", "4lzf" ]

3

[ "PUB00053803", "PUB00060062", "PUB00060063", "PUB00060064", "PUB00060066", "PUB00060086", "PUB00101592" ]

[ "12006978", "17576815", "11668681", "19215732", "8825637", "16024801", "24052813" ]

[ "Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development.", "The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.", "Genetic evidence that Sil is required for the Sonic Hedgehog response pathway.", "Mutations in STIL, ...

[ 2002, 2007, 2001, 2009, 1995, 2005, 2013 ]

7

[]

0

null

[ "Eukaryota" ]

[ 1087 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 10, 6, 2 ]

4

true

Conserved_site

STIL, proline-rich motif

PRM_STIL

9

IPR058561

58,561

Exonuclease I, C-terminal domain

Exonuc_1_C

Domain

5,975

false

This entry represents the ExoI C-terminal α-helical domain found in bacterial exonuclease I. In bacteria, exonuclease I (ExoI) is a monomeric processive 3'-5' exonuclease that degrades single-stranded DNA. The enzyme has been implicated as primarily being involved in repairing frameshift mutations. ExoI consists of thr...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF26016", "PS51785" ]

[ "ExoI_C", "EXOI_C" ]

[ 5820, 5973 ]

2

[ "EC" ]

[ "3.1.11.1" ]

[ "EC:3.1.11.1" ]

1

[ "1fxx", "2qxf", "3c94", "3c95", "3hl8", "3hp9", "4hcb", "4hcc", "4jrp", "4jrq", "4js4", "4js5", "4rg8" ]

13

[ "PUB00020975", "PUB00021628", "PUB00049176", "PUB00067024" ]

[ "1329027", "11101894", "18219121", "23609540" ]

[ "DNA deoxyribophosphodiesterase of Escherichia coli is associated with exonuclease I.", "Structure of Escherichia coli exonuclease I suggests how processivity is achieved.", "Structure of Escherichia coli exonuclease I in complex with thymidine 5'-monophosphate.", "Crystal structures of Escherichia coli exonu...

[ 1992, 2000, 2008, 2013 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Pseudomonas phage PPAT", "metagenomes" ]

[ 5898, 7, 1, 69 ]

4

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Domain

Exonuclease I, C-terminal domain

Exonuc_1_C

9

IPR058562

58,562

MJ0586, N-terminal zinc binding domain

MJ0586_N

Domain

716

false

This entry represents a likely zinc binding domain found at the N-terminal end of a group of uncharacterised archaeal transcription regulators, including HVO_2718 from Haloferax volcanii ( ) and MJ0586 from Methanocaldococcus jannaschii.

[]

0

[ "PFAM" ]

[ "PF26602" ]

[ "HVO_2718_N" ]

[ 716 ]

1

[]

0

[]

0

[ "PUB00106454" ]

[ "24825021" ]

[ "Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "unclassified sequences" ]

[ 709, 7 ]

2

[]

0

true

Domain

MJ0586, N-terminal zinc binding domain

MJ0586_N

9

IPR058563

58,563

Trs120/TRAPPC9, N-terminal domain

Trs120_TRAPPC9_N

Domain

4,988

false

This region is found at the N-terminal end of Saccharomyces cerevisiae Trafficking protein particle complex II-specific subunit 120 (Trs120), human Trafficking protein particle complex subunit 9 (TRAPPC9) and similar eukaryotic proteins. Trs120 is a subunit specific to the TRAPP II complex [ ] along with Trs65p and Trs...

[]

0

[ "PFAM" ]

[ "PF08626" ]

[ "TRAPPC9-Trs120" ]

[ 4988 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-204005", "R-DME-8876198", "R-HSA-204005", "R-HSA-8876198", "R-MMU-204005", "R-MMU-8876198", "R-SCE-204005", "R-SCE-8876198", "R-SPO-204005", "R-SPO-8876198" ]

[ "REACTOME:R-DME-204005", "REACTOME:R-DME-8876198", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-8876198", "REACTOME:R-SCE-204005", "REACTOME:R-SCE-8876198", "REACTOME:R-SPO-204005", "REACTOME:R-SPO-8876198" ]

10

[ "7e2c", "7e2d", "7e8s", "7e8t", "7e93", "7e94", "7ea3", "7u05", "7u06" ]

9

[ "PUB00033337", "PUB00055564", "PUB00055565", "PUB00143360", "PUB00161601" ]

[ "10727015", "17041589", "18801063", "15951441", "20004763" ]

[ "Identification and characterization of five new subunits of TRAPP.", "TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF.", "The TRAPP complex: insights into its architecture and function.", "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.", "A t...

[ 2000, 2006, 2008, 2005, 2009 ]

5

[]

0

null

[ "Craterilacuibacter sinensis", "Eukaryota" ]

[ 1, 4987 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 3, 2, 2, 2, 1, 2, 6, 1, 1, 11 ]

12

true

Domain

Trs120/TRAPPC9, N-terminal domain

Trs120_TRAPPC9_N

8

IPR058564

58,564

Trs120/TRAPPC9, TPR region

TPR_TRAPPC9_Trs120

Domain

4,296

false

This region is found in Saccharomyces cerevisiae Trafficking protein particle complex II-specific subunit 120 (Trs120), human Trafficking protein particle complex subunit 9 (TRAPPC9) and similar eukaryotic proteins. It contains a tetratricopeptide repeat (TPR). Trs120 is a subunit specific to the TRAPP II complex [ ] a...

[]

0

[ "PFAM" ]

[ "PF26251" ]

[ "TPR_TRAPPC9-Trs120" ]

[ 4296 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-204005", "R-DME-8876198", "R-HSA-204005", "R-HSA-8876198", "R-MMU-204005", "R-MMU-8876198", "R-SCE-204005", "R-SCE-8876198", "R-SPO-204005", "R-SPO-8876198" ]

[ "REACTOME:R-DME-204005", "REACTOME:R-DME-8876198", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-8876198", "REACTOME:R-SCE-204005", "REACTOME:R-SCE-8876198", "REACTOME:R-SPO-204005", "REACTOME:R-SPO-8876198" ]

10

[ "7e2c", "7e2d", "7e8s", "7e8t", "7e93", "7e94", "7ea3", "7u05", "7u06" ]

9

[ "PUB00033337", "PUB00055564", "PUB00055565", "PUB00143360", "PUB00161601" ]

[ "10727015", "17041589", "18801063", "15951441", "20004763" ]

[ "Identification and characterization of five new subunits of TRAPP.", "TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF.", "The TRAPP complex: insights into its architecture and function.", "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.", "A t...

[ 2000, 2006, 2008, 2005, 2009 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4296 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 3, 2, 2, 2, 1, 2, 3, 1, 1, 10 ]

12

true

Domain

Trs120/TRAPPC9, TPR region

TPR_TRAPPC9_Trs120

7

IPR058565

58,565

Trs120/TRAPPC9, first Ig-like domain

Ig_TRAPPC9_Trs120_1st

Domain

4,757

false

This domain is found in the middle region of Saccharomyces cerevisiae Trafficking protein particle complex II-specific subunit 120 (Trs120), human Trafficking protein particle complex subunit 9 (TRAPPC9) and similar eukaryotic proteins. It is predicted to have an Ig-like fold. Trs120 is a subunit specific to the TRAPP ...

[]

0

[ "PFAM" ]

[ "PF26254" ]

[ "Ig_TRAPPC9-Trs120_1st" ]

[ 4757 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-204005", "R-DME-8876198", "R-HSA-204005", "R-HSA-8876198", "R-MMU-204005", "R-MMU-8876198", "R-SCE-204005", "R-SCE-8876198", "R-SPO-204005", "R-SPO-8876198" ]

[ "REACTOME:R-DME-204005", "REACTOME:R-DME-8876198", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-8876198", "REACTOME:R-SCE-204005", "REACTOME:R-SCE-8876198", "REACTOME:R-SPO-204005", "REACTOME:R-SPO-8876198" ]

10

[ "7e2c", "7e2d", "7e8s", "7e8t", "7e93", "7e94", "7ea3", "7u05", "7u06" ]

9

[ "PUB00033337", "PUB00055564", "PUB00055565", "PUB00143360", "PUB00161601" ]

[ "10727015", "17041589", "18801063", "15951441", "20004763" ]

[ "Identification and characterization of five new subunits of TRAPP.", "TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF.", "The TRAPP complex: insights into its architecture and function.", "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.", "A t...

[ 2000, 2006, 2008, 2005, 2009 ]

5

[]

0

null

[ "Archaeoglobus fulgidus", "Eukaryota" ]

[ 3, 4754 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 3, 2, 2, 2, 1, 2, 6, 1, 1, 5 ]

12

true

Domain

Trs120/TRAPPC9, first Ig-like domain

Ig_TRAPPC9_Trs120_1st

8

IPR058567

58,567

Trs120/TRAPPC9, third Ig-like domain

Ig_TRAPPC9_Trs120_3rd

Domain

3,607

false

This entry represents the third Ig-like domain found in the middle region of Saccharomyces cerevisiae Trafficking protein particle complex II-specific subunit 120 (Trs120), human Trafficking protein particle complex subunit 9 (TRAPPC9) and similar eukaryotic proteins. Trs120 is a subunit specific to the TRAPP II comple...

[]

0

[ "PFAM" ]

[ "PF26282" ]

[ "Ig_TRAPPC9-Trs120_3rd" ]

[ 3607 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-204005", "R-DME-8876198", "R-HSA-204005", "R-HSA-8876198", "R-MMU-204005", "R-MMU-8876198", "R-SCE-204005", "R-SCE-8876198", "R-SPO-204005", "R-SPO-8876198" ]

[ "REACTOME:R-DME-204005", "REACTOME:R-DME-8876198", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-8876198", "REACTOME:R-SCE-204005", "REACTOME:R-SCE-8876198", "REACTOME:R-SPO-204005", "REACTOME:R-SPO-8876198" ]

10

[ "7e2c", "7e2d", "7e8s", "7e8t", "7e93", "7e94", "7ea3", "7u05", "7u06" ]

9

[ "PUB00033337", "PUB00055564", "PUB00055565", "PUB00143360", "PUB00161601" ]

[ "10727015", "17041589", "18801063", "15951441", "20004763" ]

[ "Identification and characterization of five new subunits of TRAPP.", "TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF.", "The TRAPP complex: insights into its architecture and function.", "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.", "A t...

[ 2000, 2006, 2008, 2005, 2009 ]

5

[]

0

null

[ "Eukaryota" ]

[ 3607 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 4, 3, 2, 2, 2, 1, 2, 3, 1, 1, 9 ]

11

true

Domain

Trs120/TRAPPC9, third Ig-like domain

Ig_TRAPPC9_Trs120_3rd

6

IPR058568

58,568

Trs120/TRAPPC9, fourth Ig-like domain

Ig_TRAPPC9_Trs120_4th

Domain

3,633

false

This entry represents the fourth Ig-like domain found in the middle region of Saccharomyces cerevisiae Trafficking protein particle complex II-specific subunit 120 (Trs120), human Trafficking protein particle complex subunit 9 (TRAPPC9) and similar eukaryotic proteins. Trs120 is a subunit specific to the TRAPP II compl...

[]

0

[ "PFAM" ]

[ "PF26283" ]

[ "Ig_TRAPPC9-Trs120_4th" ]

[ 3633 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-204005", "R-DME-8876198", "R-HSA-204005", "R-HSA-8876198", "R-MMU-204005", "R-MMU-8876198", "R-SCE-204005", "R-SCE-8876198", "R-SPO-204005", "R-SPO-8876198" ]

[ "REACTOME:R-DME-204005", "REACTOME:R-DME-8876198", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-8876198", "REACTOME:R-SCE-204005", "REACTOME:R-SCE-8876198", "REACTOME:R-SPO-204005", "REACTOME:R-SPO-8876198" ]

10

[ "7e2c", "7e2d", "7e8s", "7e8t", "7e93", "7e94", "7ea3", "7u05", "7u06" ]

9

[ "PUB00033337", "PUB00055564", "PUB00055565", "PUB00143360", "PUB00161601" ]

[ "10727015", "17041589", "18801063", "15951441", "20004763" ]

[ "Identification and characterization of five new subunits of TRAPP.", "TRAPPII subunits are required for the specificity switch of a Ypt-Rab GEF.", "The TRAPP complex: insights into its architecture and function.", "NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.", "A t...

[ 2000, 2006, 2008, 2005, 2009 ]

5

[]

0

null

[ "Eukaryota", "Lentzea rhizosphaerae" ]

[ 3632, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 4, 3, 2, 2, 2, 1, 2, 3, 1, 1, 6 ]

11

true

Domain

Trs120/TRAPPC9, fourth Ig-like domain

Ig_TRAPPC9_Trs120_4th

8

IPR058570

58,570

Homologous recombination OB-fold protein, OB-fold domain

HROB_OB

Domain

2,768

false

This entry represents the OB fold domain of human Homologous recombination OB-fold protein (HROB) and similar eukaryotic proteins. This domain, located in the C-terminal region, is involved in the stimulation of the helicase activity of MCM8-MCM9 probably by altering its conformation [ ]. During homologous recombinatio...

[]

0

[ "PFAM" ]

[ "PF15072" ]

[ "HROB" ]

[ 2768 ]

1

[]

0

[]

0

[ "PUB00093964", "PUB00093965", "PUB00161602" ]

[ "31467087", "31575675", "37535404" ]

[ "Control of homologous recombination by the HROB-MCM8-MCM9 pathway.", "Ways to unwind with HROB, a new player in homologous recombination.", "Structural and mechanistic insights into the MCM8/9 helicase complex." ]

[ 2019, 2019, 2023 ]

3

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 2767, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 2, 1, 1, 3, 5, 3 ]

7

true

Domain

Homologous recombination OB-fold protein, OB-fold domain

HROB_OB

9

IPR058571

58,571

DUF6079, third domain

DUF6079_3rd

Domain

337

false

This entry represents the third domain found in DUF6079 proteins.

[]

0

[ "PFAM" ]

[ "PF26384" ]

[ "DUF6079_3rd" ]

[ 337 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "ecological metagenomes" ]

[ 318, 10, 9 ]

3

[]

0

true

Domain

DUF6079, third domain

DUF6079_3rd

9

IPR058573

58,573

DUF6079, fifth domain

DUF6079_5th

Domain

331

false

This entry represents the fifth domain found in DUF6079 proteins.

[]

0

[ "PFAM" ]

[ "PF26387" ]

[ "DUF6079_5th" ]

[ 331 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "ecological metagenomes" ]

[ 314, 10, 7 ]

3

[]

0

true

Domain

DUF6079, fifth domain

DUF6079_5th

7

IPR058575

58,575

Nucleotidyltransferase-like domain, bacterial

NTP_transf_8_dom

Domain

1,291

false

This is a domain with a nucleotidyltransferase fold found in bacterial proteins. The fold prediction is backed up by conservation of three highly characteristic sequence motifs found in all other nucleotidyl transferases: i) pDhDhhh(h/p), where p is a polar residue and h is a hydrophobic residue; ii) upstream of the fi...

[]

0

[ "PFAM" ]

[ "PF12281" ]

[ "NTP_transf_8" ]

[ 1291 ]

1

[]

0

[]

0

[ "PUB00066751" ]

[ "19833706" ]

[ "Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1270, 3, 18 ]

3

[]

0

true

Domain

Nucleotidyltransferase-like domain, bacterial

NTP_transf_8_dom

5

IPR058577

58,577

DUF7855, C-terminal domain

DUF7855_C

Domain

211

false

This entry represents the C-terminal domain in a group of uncharacterised proteins from halobacteria. Members are around 100 residues and are predicted to adopt an α-helical domain.

[]

0

[ "PFAM" ]

[ "PF26293" ]

[ "DUF7855_C" ]

[ 211 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 211 ]

1

[]

0

true

Domain

DUF7855, C-terminal domain

DUF7855_C

3

IPR058578

58,578

IspG, TIM-barrel domain

IspG_TIM

Domain

23,471

false

This entry represents the TIM barrel domain of 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG) and homologues. In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesised by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. The MEP pathway is a...

[]

0

[ "PFAM" ]

[ "PF04551" ]

[ "GcpE" ]

[ 23471 ]

1

[ "EC" ]

[ "1.17.7.3" ]

[ "EC:1.17.7.3" ]

1

[ "2y0f", "3noy", "4g9p", "4mwa", "4s23", "4s38", "4s39", "4s3a", "4s3b", "4s3c", "4s3d", "4s3e", "4s3f" ]

13

[ "PUB00008495", "PUB00019604", "PUB00161603" ]

[ "11274098", "1521767", "16268586" ]

[ "GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.", "Sequence and characterization of the gcpE gene of Escherichia coli.", "Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli." ]

[ 2001, 1992, 2005 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "virus sp. ctVE78" ]

[ 4, 21669, 1190, 607, 1 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 2, 7 ]

4

true

Domain

IspG, TIM-barrel domain

IspG_TIM

9

IPR058579

58,579

IspG, C-terminal domain

IspG_C

Domain

23,100

false

This entry represents the C-terminal domain of 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG) and homologues. In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesised by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. The MEP pathway is a...

[]

0

[ "PFAM" ]

[ "PF26540" ]

[ "GcpE_C" ]

[ 23100 ]

1

[ "EC" ]

[ "1.17.7.3" ]

[ "EC:1.17.7.3" ]

1

[ "2y0f", "3noy", "4g9p", "4s23", "4s38", "4s39", "4s3a", "4s3b", "4s3c", "4s3d", "4s3e", "4s3f" ]

12

[ "PUB00008495", "PUB00019604", "PUB00161603" ]

[ "11274098", "1521767", "16268586" ]

[ "GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli.", "Sequence and characterization of the gcpE gene of Escherichia coli.", "Biosynthesis of isoprenoids. purification and properties of IspG protein from Escherichia coli." ]

[ 2001, 1992, 2005 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "virus sp. ctVE78" ]

[ 4, 21436, 1084, 575, 1 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 2, 6 ]

4

true

Domain

IspG, C-terminal domain

IspG_C

8

IPR058580

58,580

Domain of unknown function DUF2828

DUF2828

Domain

4,060

false

This is a uncharacterised domain found in eukaryotes and viruses. According to structure predictions and comparison, this domain may have a α-helical fold closely related to the TROVE domain suggesting possible involvement in RNA binding [ ].

[]

0

[ "PFAM" ]

[ "PF11443" ]

[ "DUF2828" ]

[ 4060 ]

1

[]

0

[]

0

[ "PUB00152793" ]

[ "36419248" ]

[ "DALI shines a light on remote homologs: One hundred discoveries." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobrevibacter millerae", "Viruses", "metagenomes" ]

[ 193, 3472, 2, 331, 62 ]

5

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 21, 13, 12 ]

3

true

Domain

Domain of unknown function DUF2828

DUF2828

9

IPR058583

58,583

Non-toxic nonhemagglutinin

NTNH

Family

116

false

This entry represents Clostridium neurotoxins, including non-toxic nonhaemagglutinin (NTNH). This family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin (BoNT)[ , , ]. Bacteria of the Clostridium genus produce protein neurotoxins, which are complexes consisting of neurotoxin (NT), haemaggl...

[ "GO:0004222", "GO:0008270", "GO:0006508" ]

[ "metalloendopeptidase activity", "zinc ion binding", "proteolysis" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "NF033911" ]

[ "botu_NTNH" ]

[ 116 ]

1

[]

0

[ "3v0a", "3v0b", "3vuo", "4zkt", "8byp", "8qft", "9arj", "9ark", "9arl", "9ea9", "9qc7", "9qc8", "9qcm", "9qco" ]

14

[ "PUB00020995", "PUB00020996", "PUB00062647", "PUB00105422", "PUB00154288", "PUB00154289" ]

[ "11233171", "11595633", "22363010", "25592073", "22828508", "26639353" ]

[ "Characterization of nicking of the nontoxic-nonhemagglutinin components of Clostridium botulinum types C and D progenitor toxin.", "Clostridium botulinum and its neurotoxins: a metabolic and cellular perspective.", "Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.", "Two-component systems...

[ 2000, 2001, 2012, 2015, 2012, 2015 ]

6

[]

0

null

[ "Clostridia", "unclassified Caudoviricetes" ]

[ 112, 4 ]

2

[]

0

true

Family

Non-toxic nonhemagglutinin

NTNH

9

IPR058584

58,584

Importin subunit beta-1/Transportin-1-like, TPR repeats

IMB1_TNPO1-like_TPR

Domain

19,379

false

This is a region of tetratricopeptide (TPR)-like repeats found in human Importin subunit beta-1 (IMB1).Transportin-1 (TNPO1) and similar eukaryotic proteins. IMB1 functions in nuclear protein import, either in association with an adapter protein, or by acting as autonomous nuclear transport receptor. Acting autonomousl...

[]

0

[ "PFAM" ]

[ "PF25574" ]

[ "TPR_IMB1" ]

[ 19379 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-450513", "R-DDI-1257604", "R-DDI-1632852", "R-DDI-165159", "R-DDI-166208", "R-DDI-3371571", "R-DDI-380972", "R-DDI-389357", "R-DDI-5218920", "R-DDI-5628897", "R-DDI-6804757", "R-DDI-8943724", "R-DDI-9639288", "R-DDI-9856530", "R-DME-140342", "R-DME-1655829", "R-DME-6798695", ...

[ "REACTOME:R-BTA-450513", "REACTOME:R-DDI-1257604", "REACTOME:R-DDI-1632852", "REACTOME:R-DDI-165159", "REACTOME:R-DDI-166208", "REACTOME:R-DDI-3371571", "REACTOME:R-DDI-380972", "REACTOME:R-DDI-389357", "REACTOME:R-DDI-5218920", "REACTOME:R-DDI-5628897", "REACTOME:R-DDI-6804757", "REACTOME:R-D...

55

[ "1qbk", "1qgk", "1qgr", "1ukl", "2bku", "2h4m", "2ot8", "2p8q", "2q5d", "2qmr", "2qna", "2z5j", "2z5k", "2z5m", "2z5n", "2z5o", "3ea5", "3lww", "3nd2", "3w5k", "4fdd", "4fq3", "4jlq", "4oo6", "4xri", "4xrk", "5j3v", "5owu", "5tqc", "5vch", "5ve8", "5w0v"...

48

[ "PUB00027218", "PUB00030197", "PUB00030257", "PUB00031678", "PUB00031809", "PUB00039663", "PUB00049076", "PUB00051635", "PUB00071404", "PUB00143621", "PUB00160693", "PUB00161607", "PUB00161608", "PUB00161609", "PUB00161610" ]

[ "12504010", "10353245", "10353244", "15537541", "14645851", "15864302", "18028944", "18708071", "20818336", "24753571", "27303791", "11682607", "11891849", "19386897", "24699649" ]

[ "Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta.", "Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.", "Structure of importin-beta bound to the IBB domain of importin-alpha.", "Structure of the Cand1-Cul1-Roc1 complex reveals regula...

[ 2002, 1999, 1999, 2004, 2003, 2005, 2007, 2008, 2010, 2014, 2016, 2001, 2002, 2009, 2014 ]

15

[]

0

null

[ "Eukaryota" ]

[ 19379 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 33, 5, 9, 17, 31, 17, 5, 25, 24, 2, 4, 99 ]

12

true

Domain

Importin subunit beta-1/Transportin-1-like, TPR repeats

IMB1_TNPO1-like_TPR

2

IPR058585

58,585

VIN3-like, fibronectin type-III domain

Fn3_VIN3

Domain

2,334

false

This entry represents the fibronectin type-III domain in Protein Vernalisation Insensitive 3 from Arabidopsis thaliana (VIN3) and similar plant sequences including VIN3-like protein. This domain is predicted to contain a fibronectin type-III and is often found associated with . VIN3 plays a central role in vernalizatio...

[]

0

[ "PFAM" ]

[ "PF23376" ]

[ "Fn3_VIN3" ]

[ 2334 ]

1

[]

0

[]

0

[ "PUB00076963", "PUB00132801" ]

[ "17114575", "14712276" ]

[ "A PHD finger protein involved in both the vernalization and photoperiod pathways in Arabidopsis.", "Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3." ]

[ 2006, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2334 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 22, 8, 44 ]

3

true

Domain

VIN3-like, fibronectin type-III domain

Fn3_VIN3

1

IPR058586

58,586

Apical junction molecule ajm1, alpha/beta domain

Ajm-1

Domain

1,607

false

This domain is found in the Apical junction molecule Ajm-1 from C. elegans and related proteins. It is predicted to fold into an α/β structure with significant similarity to domains members of CcmS-like superfamily. Ajm-1 controls adherens junction integrity in C.elegans and is required for the correct rate and complet...

[]

0

[ "PFAM" ]

[ "PF26649" ]

[ "Ajm-1" ]

[ 1607 ]

1

[]

0

[]

0

[ "PUB00088455" ]

[ "11715019" ]

[ "Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia." ]

[ 2001 ]

1

[]

0

null

[ "Desertifilum tharense IPPAS B-1220", "Eukaryota" ]

[ 1, 1606 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 4, 1, 1, 1 ]

6

true

Domain

Apical junction molecule ajm1, alpha/beta domain

Ajm-1

6

IPR058587

58,587

Chaperone protein CcmS

CcmS

Domain

240

false

This entry represents the chaperone protein CcmS, which is involved in beta-carboxysome assembly and interacts with beta-carboxysome proteins. CcmS specifically interacts with the C-terminal extension of the carboxysome shell protein CcmK1 [ , ]. Upon binding to CcmS, this C-terminal segment of CcmK1 folds into an amph...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF049993", "PF26619" ]

[ "slr1911_CcmS", "CcmS" ]

[ 239, 240 ]

2

[]

0

[ "8zlh", "8zlz", "9iur", "9iv3", "9iv7" ]

5

[ "PUB00161170", "PUB00161171", "PUB00163024" ]

[ "39172695", "40125605", "37271831" ]

[ "Molecular interactions of the chaperone CcmS and carboxysome shell protein CcmK1 that mediate β-carboxysome assembly.", "Assembly mechanism of the β-carboxysome shell mediated by the chaperone CcmS.", "Novel protein CcmS is required for stabilization of the assembly of β-carboxysome in Synechocystis sp. strain...

[ 2024, 2025, 2023 ]

3

[]

0

null

[ "Cyanophyceae" ]

[ 240 ]

1

[]

0

true

Domain

Chaperone protein CcmS

CcmS

6

IPR058588

58,588

Type II CBASS E2 protein

E2-CBASS

Domain

646

false

E2-CBASS is a subtype of the bacterial CBASS (Cyclic oligonucleotide-Based Anti-Phage Signaling System), which is an innate immune system found in bacteria and archaea that protects against phage infections. CBASS systems work by detecting phage infection and triggering a form of programmed cell death (abortive infecti...

[]

0

[ "PFAM" ]

[ "PF26395" ]

[ "E2-CBASS" ]

[ 646 ]

1

[]

0

[ "8hsb", "8yjy" ]

2

[ "PUB00161225" ]

[ "38649411" ]

[ "Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Halobacteriales", "Ostreobium quekettii", "metagenomes" ]

[ 630, 3, 2, 1, 10 ]

5

[]

0

true

Domain

Type II CBASS E2 protein

E2-CBASS

6

IPR058589

58,589

Endo-alpha(1,4)-fucoidanase Mef1

Mef1

Domain

49

false

This entry represents the Endo-alpha(1,4)-fucoidanase Mef1 and related bacterial proteins mainly from Pseudomonadati kingdom. Mef1 catalyses the cleavage of alpha(1,4)-linkages between fucose residues sulfated on C2 in fucoidan [ ]. It folds into a classical TIM β-barrel fold. The active site of this enzyme is located ...

[]

0

[ "PFAM" ]

[ "PF26376" ]

[ "Mef1" ]

[ 49 ]

1

[]

0

[ "6m8n", "8bpd" ]

2

[ "PUB00161339" ]

[ "37877949" ]

[ "Structural and functional characterization of the novel endo-α(1,4)-fucoidanase Mef1 from the marine bacterium Muricauda eckloniae." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria" ]

[ 49 ]

1

[]

0

true

Domain

Endo-alpha(1,4)-fucoidanase Mef1

Mef1

4

IPR058590

58,590

Tle-like phospholipase domain

Tle-like

Domain

2,816

false

The Tle (Type VI lipase effector) phospholipase domains are specialised protein domains found in bacterial toxins, particularly those secreted via the Type VI Secretion System (T6SS). These domains function as phospholipases that hydrolyse phospholipids, key components of cell membranes allowing bacteria to attack and ...

[]

0

[ "PFAM" ]

[ "PF26363" ]

[ "Phospholipase-like" ]

[ 2816 ]

1

[]

0

[ "7ubz", "9cys" ]

2

[ "PUB00161412" ]

[ "39394186" ]

[ "Advanced glycation end-product crosslinking activates a type VI secretion system phospholipase effector protein." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "ecological metagenomes" ]

[ 2653, 150, 3, 10 ]

4

[]

0

true

Domain

Tle-like phospholipase domain

Tle-like

1

IPR058591

58,591

Glucosyltransferase 3-like, N-terminal domain

Gtf3_N

Domain

1,701

false

This domain is found N-terminal is Glucosyltransferase 3 (Gtf3) from from S. pneumoniae, its homologue GtfC from S. agalactiae and related proteins. This domain contains a loop region which is critical for the substrate binding and the enzymatic activity [ ]. This domain is also found in the Beta-1,6-galactofuranosyltr...

[]

0

[ "PFAM" ]

[ "PF26334" ]

[ "Gtf3_N" ]

[ 1701 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

200

[ "3qkw", "3rhz", "4w6q", "9htx", "9hu9", "9hua" ]

6

[ "PUB00064837", "PUB00078872", "PUB00094451", "PUB00094452", "PUB00094454" ]

[ "15489421", "17047874", "25404702", "30371779", "21653318" ]

[ "Four proteins encoded in the gspB-secY2A2 operon of Streptococcus gordonii mediate the intracellular glycosylation of the platelet-binding protein GspB.", "Expression and initial characterization of WbbI, a putative D-Galf:alpha-D-Glc beta-1,6-galactofuranosyltransferase from Escherichia coli K-12.", "A conser...

[ 2004, 2006, 2015, 2019, 2011 ]

5

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 1690, 7, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Glucosyltransferase 3-like, N-terminal domain

Gtf3_N

6

IPR058592

58,592

Glucosyltransferase 3-like, C-terminal domain

Gtf3_C

Domain

1,902

false

This domain is found C-terminal is Glucosyltransferase 3 (Gtf3) from from S. pneumoniae, its homologue GtfC from S. agalactiae and related proteins. This domain is also found in the beta-1,6-galactofuranosyltransferase WbbI. Streptococcus agalactiae is the leading cause of bacterial sepsis and meningitis among newborns...

[]

0

[ "PFAM" ]

[ "PF26337" ]

[ "Gtf3_C" ]

[ 1902 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

200

[ "3qkw", "3rhz", "4w6q", "9htx", "9hu9", "9hua" ]

6

[ "PUB00064837", "PUB00078872", "PUB00094451", "PUB00094452", "PUB00094454" ]

[ "15489421", "17047874", "25404702", "30371779", "21653318" ]

[ "Four proteins encoded in the gspB-secY2A2 operon of Streptococcus gordonii mediate the intracellular glycosylation of the platelet-binding protein GspB.", "Expression and initial characterization of WbbI, a putative D-Galf:alpha-D-Glc beta-1,6-galactofuranosyltransferase from Escherichia coli K-12.", "A conser...

[ 2004, 2006, 2015, 2019, 2011 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 8, 1874, 7, 13 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Glucosyltransferase 3-like, C-terminal domain

Gtf3_C

2

IPR058593

58,593

ARB_07466-like, C-terminal domain

ARB_07466-like_C

Domain

6,758

false

This domain is found at the C-terminal end of Uncharacterized secreted protein ARB_07466 and the LysM domain-containing protein Spr1875 from Streptococcus pneumoniae (VldE, ), which has endopeptidase activity [ ]. This domain shows an α-β configuration.

[]

0

[ "PFAM" ]

[ "PF26571" ]

[ "VldE" ]

[ 6758 ]

1

[]

0

[ "9flh", "9flj", "9flk", "9fll", "9flm", "9fln" ]

6

[ "PUB00161514" ]

[ "39722888" ]

[ "Characterization of VldE (Spr1875), a Pneumococcal Two-State l,d-Endopeptidase with a Four-Zinc Cluster in the Active Site." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 6086, 246, 382, 44 ]

4

[]

0

true

Domain

ARB_07466-like, C-terminal domain

ARB_07466-like_C

6

IPR058595

58,595

Avidin-like protein

Avidin-like

Family

2,039

false

This entry represents a group of uncharacterised proteins primarily from the bacteria. Members of this family are generally around 100-120 amino acids in length. Its predicted structure forms an 8-stranded β- barrel closely structurally related to avidins.

[]

0

[ "PFAM" ]

[ "PF26421" ]

[ "Avidin_like" ]

[ 2039 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "marine sediment metagenome" ]

[ 1897, 74, 67, 1 ]

4

[]

0

true

Family

Avidin-like protein

Avidin-like

5

IPR058596

58,596

TraC-like domain

TraC-like_dom

Domain

2,816

false

This entry represents a domain of a group of uncharacterised prokaryotic proteins. This domain is related to found in the TraC protein involved in conjugal transfer.

[]

0

[ "PFAM" ]

[ "PF26593" ]

[ "TraC-like" ]

[ 2816 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 462, 2337, 17 ]

3

[]

0

true

Domain

TraC-like domain

TraC-like_dom

3

IPR058597

58,597

PrgI-like domain

PrgI-like_dom

Domain

335

false

This entry represents the N-terminal domain of a group of uncharacterised proteins from halobacteria. This domain resembles the PrgI like protein ( ) suggesting a role in secretion or conjugal transfer. This domain, often found associated with , appears to contain two transmembrane helices.

[]

0

[ "PFAM" ]

[ "PF26592" ]

[ "PrgI_like" ]

[ 335 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Halobacteria" ]

[ 2, 333 ]

2

[]

0

true

Domain

PrgI-like domain

PrgI-like_dom

4

IPR058598

58,598

Glycine zipper-like domain

Gly_zipper-like_dom

Domain

1,508

false

This domain is found in a group of uncharacterised integral membrane proteins found in prokaryotes. These proteins contain two predicted transmembrane helices and a glycine zipper motif.

[]

0

[ "PFAM" ]

[ "PF26273" ]

[ "Gly_zipper" ]

[ 1508 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "Tanacetum coccineum", "ecological metagenomes" ]

[ 1326, 172, 1, 9 ]

4

[]

0

true

Domain

Glycine zipper-like domain

Gly_zipper-like_dom

9

IPR058599

58,599

SMAUG/ZCCHC2-like, PHAT domain

PHAT_Smg/ZCCHC2-like

Domain

4,754

false

This PHAT (a pseudo-HEAT-repeat analogous topology) domain is found in SMAUG from fruit flies (Smg) and related animal proteins, including human Zinc finger CCHC domain-containing protein 2 (ZCCHC2). SMAUG is a key regulator of posterior patterning and crucial for the maternal-to-zygotic transition of gene expression o...

[]

0

[ "PFAM" ]

[ "PF26034" ]

[ "PHAT_SMAUG" ]

[ 4754 ]

1

[]

0

[ "8oij", "8oik" ]

2

[ "PUB00075408", "PUB00097386", "PUB00097387", "PUB00161408", "PUB00161614" ]

[ "14685270", "20510020", "16221671", "37523566", "8895661" ]

[ "Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression.", "SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity.", "Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules...

[ 2004, 2010, 2005, 2023, 1996 ]

5

[]

0

null

[ "Opisthokonta" ]

[ 4754 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 2, 14, 8, 20 ]

5

true

Domain

SMAUG/ZCCHC2-like, PHAT domain

PHAT_Smg/ZCCHC2-like

7

IPR058600

58,600

YhjD-like

Family

1,955

false

This entry represents the uncharacterised protein YhjD and similar sequences from bacillales. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF26325" ]

[ "YhjD" ]

[ 1955 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Caudoviricetes", "Phytophthora kernoviae 00238/432" ]

[ 1949, 5, 1 ]

3

[]

0

true

Family

YhjD-like

9

IPR058601

58,601

Phage PhiTE, phiTE_015-like

Phage_phiTE_015-like

Family

1,203

false

This entry represents a family of uncharacterised phage proteins that includes Phage PhiTE PhiTE_015 ( ). Structure prediction suggests that this family does not adopt a globular structure. Many proteins contain a RXXFE motif at their N-terminal. This family also includes proteobacterial prophages.

[]

0

[ "PFAM" ]

[ "PF26207" ]

[ "Phage_phiTE_015" ]

[ 1203 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "Tanacetum cinerariifolium", "Viruses", "metagenomes" ]

[ 905, 1, 292, 5 ]

4

[]

0

true

Family

Phage PhiTE, phiTE_015-like

Phage_phiTE_015-like

5

IPR058602

58,602

YAG7-like, dimerisation domain

YAG7_dimerisation_dom

Domain

1,042

false

This entry represents a domain found in Uncharacterized protein C12G12.07c and YAG7 protein from S. pombe and similar proteins from ascomycetes. This domain is structurally related to the dimerisation domain in caprin-1 ( ) and PAN3 and likely has a role as dimerisation domain.

[]

0

[ "PFAM" ]

[ "PF26434" ]

[ "YAG7_C" ]

[ 1042 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1042 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Domain

YAG7-like, dimerisation domain

YAG7_dimerisation_dom

9

IPR058603

58,603

Protein of unknown function DUF8167, second domain

DUF8167_2nd

Domain

673

false

This entry represents the second domain in a family of uncharacterised proteins from halophilic archaea that contain four domains. These proteins are typically around 400 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF26502" ]

[ "DUF8167_2nd" ]

[ 673 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 673 ]

1

[]

0

true

Domain

Protein of unknown function DUF8167, second domain

DUF8167_2nd

7

IPR058604

58,604

Protein of unknown function DUF8167, third domain

DUF8167_3rd

Domain

661

false

This entry represents the third domain from a family of uncharacterised proteins from halophilic archaea that contain four domains. These proteins are typically around 400 amino acids in length. This domain adopts a five stranded β-barrel structure.

[]

0

[ "PFAM" ]

[ "PF26503" ]

[ "DUF8167_3rd" ]

[ 661 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 661 ]

1

[]

0

true

Domain

Protein of unknown function DUF8167, third domain

DUF8167_3rd

1

IPR058605

58,605

Biotin synthase auxiliary protein, C-terminal domain

BsaP_C

Domain

1,303

false

This domain is found at the C-terminal end of Biotin synthase auxiliary protein from Mycobacterium tuberculosis (BsaP) and similar proteins from actinomycetes. BsaP is required for the activity of the biotin synthase BioB [ ]. These proteins play a crucial auxiliary role in the biotin biosynthesis pathway, which is vit...

[]

0

[ "PFAM" ]

[ "PF26519" ]

[ "BsaP" ]

[ 1303 ]

1

[]

0

[]

0

[ "PUB00161158" ]

[ "38755122" ]

[ "Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin." ]

[ 2024 ]

1

[]

0

null

[ "Actinomycetota", "freshwater metagenome" ]

[ 1299, 4 ]

2

[]

0

true

Domain

Biotin synthase auxiliary protein, C-terminal domain

BsaP_C

2

IPR058606

58,606

Protein capicua homolog-like, C-terminal tri-helical domain

HTH_Cic_C

Domain

2,134

false

This helix-turn-helix (HTH) domain is found at the C-terminal of mouse Protein capicua homolog (Cic) and similar proteins found in animals. Cic is a transcriptional repressor which plays a role in development of the central nervous system. It is involved in brain development together with ATXN1 and ATXN1L [ , ].

[]

0

[ "PFAM" ]

[ "PF25981" ]

[ "HTH_Cic_C" ]

[ 2134 ]

1

[]

0

[ "7m5w" ]

1

[ "PUB00053281", "PUB00148730", "PUB00148732" ]

[ "17190598", "12393275", "28288114" ]

[ "ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.", "CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons.", "Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in m...

[ 2006, 2002, 2017 ]

3

[]

0

null

[ "Eumetazoa", "bird metagenome" ]

[ 2133, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 7, 6, 7, 3, 2 ]

6

true

Domain

Protein capicua homolog-like, C-terminal tri-helical domain

HTH_Cic_C

8

IPR058608

58,608

Oligoribonuclease NrnB, C-terminal domain

NrnB_C

Domain

442

false

This entry represents the C-terminal domain of the Oligoribonuclease NrnB from Bacillus subtilis and similar proteins found in bacillales. NrnB is involved in the degradation of RNA oligonucleotides. It specifically targets RNA fragments that are 5 nucleotides long, breaking them down in a 3'- to 5'-direction and exhib...

[]

0

[ "PFAM" ]

[ "PF26386" ]

[ "NrnB_C" ]

[ 442 ]

1

[]

0

[]

0

[ "PUB00155208" ]

[ "19553197" ]

[ "Degradation of nanoRNA is performed by multiple redundant RNases in Bacillus subtilis." ]

[ 2009 ]

1

[]

0

null

[ "Bacilli", "Rhizophagus irregularis" ]

[ 441, 1 ]

2

[]

0

true

Domain

Oligoribonuclease NrnB, C-terminal domain

NrnB_C

6

IPR058609

58,609

Histone-lysine N-methyltransferase CLF-like, HTH domain

HTH_CLF-like

Domain

1,948

false

This domain is found towards the N-terminal end of Histone-lysine N-methyltransferase CLF from Arabidopsis thaliana and similar proteins found in plants. CLF is the catalytic subunit of some polycomb group protein complexes, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected ...

[]

0

[ "PFAM" ]

[ "PF25996" ]

[ "HTH_CLF_N" ]

[ 1948 ]

1

[ "EC" ]

[ "2.1.1.356" ]

[ "EC:2.1.1.356" ]

1

[]

0

[ "PUB00058001", "PUB00058005", "PUB00058006", "PUB00058007", "PUB00110836", "PUB00161279" ]

[ "11250158", "9052779", "9736998", "11063708", "17881378", "30307069" ]

[ "Polycomb group genes control pattern formation in plant seed.", "A Polycomb-group gene regulates homeotic gene expression in Arabidopsis.", "The CURLY LEAF gene controls both division and elongation of cells during the expansion of the leaf blade in Arabidopsis thaliana.", "Genetic analysis of incurvata muta...

[ 2001, 1997, 1998, 2000, 2007, 2019 ]

6

[]

0

null

[ "Streptophytina" ]

[ 1948 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 39, 3, 39 ]

3

true

Domain

Histone-lysine N-methyltransferase CLF-like, HTH domain

HTH_CLF-like

5

IPR058610

58,610

WIT1/2, N-terminal helical bundle

WIT1_2_N

Domain

1,667

false

This domain is found at the N-terminal end of WIT1/2 from Arabidopsis thaliana. This domain is predicted to show a three-helical bundle. WIT1 and WIT2 are tail-anchored proteins [ ] required for the nuclear envelope anchoring of RANGAP (Ran GTPase activating protein) in root tips in Arabidopsis [ ]. They could be invol...

[]

0

[ "PFAM" ]

[ "PF26581" ]

[ "WIT1_2_N" ]

[ 1667 ]

1

[]

0

[]

0

[ "PUB00090377", "PUB00090378", "PUB00090379", "PUB00090380", "PUB00161547" ]

[ "18591351", "12821639", "25759303", "26409047", "32226330" ]

[ "Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP.", "The tale of tail-anchored proteins: coming from the cytosol and looking for a membrane.", "Plant nuclear shape is independently determin...

[ 2008, 2003, 2015, 2015, 2020 ]

5

[]

0

null

[ "Eukaryota", "Petrachloros mirabilis ULC683" ]

[ 1666, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 14, 5, 11 ]

3

true

Domain

WIT1/2, N-terminal helical bundle

WIT1_2_N

7

IPR058611

58,611

SMCHD1, Ig-like domain 1

Ig_SMCHD1_1st

Domain

1,060

false

This entry represents the first Ig-like domain in structural maintenance of chromosomes flexible hinge domain-containing (SMC-FH) animal proteins, including human Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1). This domain is part of a long linker region located between the SM...

[]

0

[ "PFAM" ]

[ "PF26194" ]

[ "Ig_SMCHD1_1st" ]

[ 1060 ]

1

[]

0

[]

0

[ "PUB00112366", "PUB00161296", "PUB00161297", "PUB00161615", "PUB00161616", "PUB00161617" ]

[ "25294876", "32546545", "32779700", "23542155", "24790221", "29748383" ]

[ "Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.", "Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues.", "Relating SMC...

[ 2014, 2020, 2020, 2013, 2014, 2018 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 1060 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 1, 4 ]

4

true

Domain

SMCHD1, Ig-like domain 1

Ig_SMCHD1_1st

8

IPR058612

58,612

SMCHD1, Ig-like domain 2

Ig_SMCHD1_2nd

Domain

1,027

false

This entry represents the second Ig-like domain in structural maintenance of chromosomes flexible hinge domain-containing (SMC-FH) animal proteins, including human Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1). This domain is part of a long linker region located between the S...

[]

0

[ "PFAM" ]

[ "PF26195" ]

[ "Ig_SMCHD1_2nd" ]

[ 1027 ]

1

[]

0

[]

0

[ "PUB00112366", "PUB00161296", "PUB00161297", "PUB00161615", "PUB00161616", "PUB00161617" ]

[ "25294876", "32546545", "32779700", "23542155", "24790221", "29748383" ]

[ "Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.", "Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues.", "Relating SMC...

[ 2014, 2020, 2020, 2013, 2014, 2018 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 1027 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 1, 4 ]

4

true

Domain

SMCHD1, Ig-like domain 2

Ig_SMCHD1_2nd

5

IPR058613

58,613

SMCHD1, Ig-like domain 4

Ig_SMCHD1_4th

Domain

1,075

false

This entry represents the fourth Ig-like domain in structural maintenance of chromosomes flexible hinge domain-containing (SMC-FH) animal proteins, including human Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1). This domain is part of a long linker region located between the S...

[]

0

[ "PFAM" ]

[ "PF26196" ]

[ "Ig_SMCHD1_4th" ]

[ 1075 ]

1

[]

0

[]

0

[ "PUB00112366", "PUB00161296", "PUB00161297", "PUB00161615", "PUB00161616", "PUB00161617" ]

[ "25294876", "32546545", "32779700", "23542155", "24790221", "29748383" ]

[ "Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.", "Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues.", "Relating SMC...

[ 2014, 2020, 2020, 2013, 2014, 2018 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 1075 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 1, 4 ]

4

true

Domain

SMCHD1, Ig-like domain 4

Ig_SMCHD1_4th

2

IPR058614

58,614

SMCHD1, Ig-like domain 5

Ig_SMCHD1_5th

Domain

1,054

false

This entry represents the fifth Ig-like domain in structural maintenance of chromosomes flexible hinge domain-containing (SMC-FH) animal proteins, including human Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1). This domain is part of a long linker region located between the SM...

[]

0

[ "PFAM" ]

[ "PF26197" ]

[ "Ig_SMCHD1_5th" ]

[ 1054 ]

1

[]

0

[]

0

[ "PUB00112366", "PUB00161296", "PUB00161297", "PUB00161615", "PUB00161616", "PUB00161617" ]

[ "25294876", "32546545", "32779700", "23542155", "24790221", "29748383" ]

[ "Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.", "Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues.", "Relating SMC...

[ 2014, 2020, 2020, 2013, 2014, 2018 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 1054 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 1, 3 ]

4

true

Domain

SMCHD1, Ig-like domain 5

Ig_SMCHD1_5th

7

IPR058615

58,615

SMCHD1, Ig-like domain 6

Ig_SMCHD1_6th

Domain

1,088

false

This entry represents the sixth Ig-like domain in structural maintenance of chromosomes flexible hinge domain-containing (SMC-FH) animal proteins, including human Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1). This domain is part of a long linker region located between the SM...

[]

0

[ "PFAM" ]

[ "PF26198" ]

[ "Ig_SMCHD1_6th" ]

[ 1088 ]

1

[]

0

[]

0

[ "PUB00112366", "PUB00161296", "PUB00161297", "PUB00161615", "PUB00161616", "PUB00161617" ]

[ "25294876", "32546545", "32779700", "23542155", "24790221", "29748383" ]

[ "Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.", "Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues.", "Relating SMC...

[ 2014, 2020, 2020, 2013, 2014, 2018 ]

6

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 11, 1077 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 1, 4 ]

4

true

Domain

SMCHD1, Ig-like domain 6

Ig_SMCHD1_6th

7

IPR058616

58,616

SMCHD1, Ig-like domain 8

Ig_SMCHD1_8th

Domain

1,125

false

This entry represents the eighth Ig-like domain in structural maintenance of chromosomes flexible hinge domain-containing (SMC-FH) animal proteins, including human Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1). This domain is part of a long linker region located between the S...

[]

0

[ "PFAM" ]

[ "PF26199" ]

[ "Ig_SMCHD1_8th" ]

[ 1125 ]

1

[]

0

[]

0

[ "PUB00112366", "PUB00161296", "PUB00161297", "PUB00161615", "PUB00161616", "PUB00161617" ]

[ "25294876", "32546545", "32779700", "23542155", "24790221", "29748383" ]

[ "Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.", "Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues.", "Relating SMC...

[ 2014, 2020, 2020, 2013, 2014, 2018 ]

6

[]

0

null

[ "Eukaryota" ]

[ 1125 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 1, 4 ]

4

true

Domain

SMCHD1, Ig-like domain 8

Ig_SMCHD1_8th

3

IPR058617

58,617

SMCHD1, Ig-like domain 7

Ig_SMCHD1_7th

Domain

1,066

false

This entry represents the seventh Ig-like domain in structural maintenance of chromosomes flexible hinge domain-containing (SMC-FH) animal proteins, including human Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1). This domain is part of a long linker region located between the ...

[]

0

[ "PFAM" ]

[ "PF26201" ]

[ "Ig_SMCHD1_7th" ]

[ 1066 ]

1

[]

0

[]

0

[ "PUB00112366", "PUB00161296", "PUB00161297", "PUB00161615", "PUB00161616", "PUB00161617" ]

[ "25294876", "32546545", "32779700", "23542155", "24790221", "29748383" ]

[ "Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.", "Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues.", "Relating SMC...

[ 2014, 2020, 2020, 2013, 2014, 2018 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 1066 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 1, 4 ]

4

true

Domain

SMCHD1, Ig-like domain 7

Ig_SMCHD1_7th

6

IPR058618

58,618

Virulence sensor histidine kinase PhoQ-like

PhoQ

Family

1,346

false

This entry represents a group of proteins from enterobacterales, including Virulence sensor histidine kinase PhoQ from Salmonella typhimurium. PhoQ is a member of the two-component regulatory system PhoP/PhoQ, which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg2+ environments ...

[ "GO:0000155", "GO:0016772", "GO:0000160" ]

[ "phosphorelay sensor kinase activity", "transferase activity, transferring phosphorus-containing groups", "phosphorelay signal transduction system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "NF008077" ]

[ "PRK10815.1" ]

[ 1346 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.7.13.3", "3.1.3.-", "PWY-4702", "PWY-5491", "PWY-6148", "PWY-6352", "PWY-6365", "PWY-6366", "PWY-6368", "PWY-6456", "PWY-6575", "PWY-6627", "PWY-6664", "PWY-6686", "PWY-6720", "PWY-6724", "PWY-6955", "PWY-6990", "PWY-6991", "PWY-7018", "PWY-7119", "PWY-7321", "PWY-7531...

[ "EC:2.7.13.3", "EC:3.1.3.-", "METACYC:PWY-4702", "METACYC:PWY-5491", "METACYC:PWY-6148", "METACYC:PWY-6352", "METACYC:PWY-6365", "METACYC:PWY-6366", "METACYC:PWY-6368", "METACYC:PWY-6456", "METACYC:PWY-6575", "METACYC:PWY-6627", "METACYC:PWY-6664", "METACYC:PWY-6686", "METACYC:PWY-6720",...

37

[]

0

[ "PUB00161618", "PUB00161619", "PUB00161620", "PUB00161621", "PUB00161622", "PUB00161623", "PUB00161624" ]

[ "10807931", "11160113", "12618457", "15910283", "2544889", "32413287", "9573193" ]

[ "The phosphatase activity is the target for Mg2+ regulation of the sensor protein PhoQ in Salmonella.", "Characterization of the catalytic activities of the PhoQ histidine protein kinase of Salmonella enterica serovar Typhimurium.", "Mutational analysis of the residue at position 48 in the Salmonella enterica S...

[ 2000, 2001, 2003, 2005, 1989, 2020, 1998 ]

7

[ "IPR050428" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 1341, 5 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Virulence sensor histidine kinase PhoQ-like

PhoQ

3

IPR058619

58,619

Virulence sensor histidine kinase PhoQ/CarS-like, histidine kinase-like ATPase domain

PhoQ/CarS-like_HATPase

Domain

3,505

false

This entry represents the histidine kinase-like ATPase (HATPase) domain of Virulence sensor histidine kinase PhoQ from Salmonella typhimurium, Sensor protein kinase CarS from Pseudomonas aeruginosa and similar protein members of two-component sensor histidine kinases from gammaproteobacteria. PhoQ is the histidine kina...

[]

0

[ "CDD" ]

[ "cd16954" ]

[ "HATPase_PhoQ-like" ]

[ 3505 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.7.13.3", "3.1.3.-", "PWY-4702", "PWY-5491", "PWY-6148", "PWY-6352", "PWY-6365", "PWY-6366", "PWY-6368", "PWY-6456", "PWY-6575", "PWY-6627", "PWY-6664", "PWY-6686", "PWY-6720", "PWY-6724", "PWY-6955", "PWY-6990", "PWY-6991", "PWY-7018", "PWY-7119", "PWY-7321", "PWY-7531...

[ "EC:2.7.13.3", "EC:3.1.3.-", "METACYC:PWY-4702", "METACYC:PWY-5491", "METACYC:PWY-6148", "METACYC:PWY-6352", "METACYC:PWY-6365", "METACYC:PWY-6366", "METACYC:PWY-6368", "METACYC:PWY-6456", "METACYC:PWY-6575", "METACYC:PWY-6627", "METACYC:PWY-6664", "METACYC:PWY-6686", "METACYC:PWY-6720",...

37

[ "1id0", "3cgy", "3cgz" ]

3

[ "PUB00025980", "PUB00112322", "PUB00112323", "PUB00112382", "PUB00144943" ]

[ "11493605", "10637609", "10339418", "9680222", "11222580" ]

[ "Structural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism.", "GHKL, an emergent ATPase/kinase superfamily.", "Signal transduction: Gyrating protein kinases.", "A regulatory cascade involving AarG, a putative sensor kinase, controls the expression of...

[ 2001, 2000, 1999, 1998, 2001 ]

5

[ "IPR003594" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3489, 6, 10 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Virulence sensor histidine kinase PhoQ/CarS-like, histidine kinase-like ATPase domain

PhoQ/CarS-like_HATPase

3

IPR058620

58,620

Sporulation membrane protein YtrI, C-terminal domain

YtrI_C

Domain

1,373

false

This entry represents the C-terminal domain of Sporulation membrane protein YtrI from Bacillus subtilis and similar proteins from firmicutes. YtrI is involved in the process of sporulation [ , ]. Sporulation is a critical developmental process in certain bacteria where the cell undergoes a complex transformation to for...

[]

0

[ "PFAM" ]

[ "PF26347" ]

[ "YtrI_C" ]

[ 1373 ]

1

[]

0

[]

0

[ "PUB00012907", "PUB00034546" ]

[ "12662922", "15547282" ]

[ "The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis.", "Unmasking novel sporulation genes in Bacillus subtilis." ]

[ 2003, 2004 ]

2

[]

0

null

[ "Bacillota", "Phytophthora kernoviae 00238/432", "ecological metagenomes" ]

[ 1370, 1, 2 ]

3

[]

0

true

Domain

Sporulation membrane protein YtrI, C-terminal domain

YtrI_C

7

IPR058621

58,621

HelY-like, SH3 domain

SH3_HelY

Domain

3,869

false

This domain is found in the probable helicase HelY from Mycobacterium tuberculosis and similar bacterial sequences. This domain is predicted to show an α-β structure. Its specific function is unknown.

[]

0

[ "PFAM" ]

[ "PF26090" ]

[ "SH3_HelY" ]

[ 3869 ]

1

[ "EC", "METACYC" ]

[ "3.6.4.-", "PWY-7250" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250" ]

2

[]

0

[]

0

[]

0

null

[ "Actinomycetota", "metagenomes" ]

[ 3769, 100 ]

2

[]

0

true

Domain

HelY-like, SH3 domain

SH3_HelY

3

IPR058623

58,623

Macrolide export protein MacA

MacA

Family

1,743

false

This entry represents Macrolide export protein MacA from Escherichia coli and similar sequences from proteobacteria. MacA is part of the tripartite efflux system MacAB-TolC [ , , , , ]. and confers macrolide resistance via active drug efflux [ ]. In addition, MacA binds tightly rough-core lipopolysaccharide (R-LPS), su...

[ "GO:0022857", "GO:1990961", "GO:0019898" ]

[ "transmembrane transporter activity", "xenobiotic detoxification by transmembrane export across the plasma membrane", "extrinsic component of membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "NF008606" ]

[ "PRK11578.1" ]

[ 1743 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9638334", "R-HSA-9760173", "R-HSA-9913143" ]

[ "REACTOME:R-HSA-9638334", "REACTOME:R-HSA-9760173", "REACTOME:R-HSA-9913143" ]

3

[ "3fpp", "5nik", "5nil" ]

3

[ "PUB00071887", "PUB00071888", "PUB00071889", "PUB00159064", "PUB00161626", "PUB00161627", "PUB00161628" ]

[ "23974027", "21696464", "18955484", "28504659", "40083904", "40461577", "17214741" ]

[ "MacA, a periplasmic membrane fusion protein of the macrolide transporter MacAB-TolC, binds lipopolysaccharide core specifically and with high affinity.", "The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by MacB transporter.", "MacB ABC transporter is a dimer w...

[ 2013, 2011, 2009, 2017, 2025, 2025, 2007 ]

7

[ "IPR006143" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "plant metagenome" ]

[ 1735, 2, 6 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Macrolide export protein MacA

MacA

2

IPR058624

58,624

Multidrug resistance protein MdtA-like, alpha-helical hairpin domain

MdtA-like_HH

Domain

63,063

false

This domain is found in a group of bacterial periplasmic membrane fusion proteins (MFPs) that are components of the RND tripartite drug efflux pumps, including Multidrug resistance protein MdtA and Macrolide export protein MacA [ ]. MFPs bridge the outer membrane factor and an inner membrane transporter. The most chara...

[]

0

[ "PFAM" ]

[ "PF25876" ]

[ "HH_MFP_RND" ]

[ 63063 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9638334", "R-HSA-9760173", "R-HSA-9913143" ]

[ "REACTOME:R-HSA-9638334", "REACTOME:R-HSA-9760173", "REACTOME:R-HSA-9913143" ]

3

[ "1t5e", "1vf7", "2f1m", "2v4d", "3fpp", "4dk1", "5ng5", "5nik", "5nil", "5o66", "5v5s", "6iok", "6iol", "6ta5", "6ta6", "6vej", "9j3d", "9j3e", "9v53", "9v55" ]

20

[ "PUB00040497", "PUB00161442", "PUB00161626" ]

[ "16531241", "33009415", "40083904" ]

[ "Conformational flexibility in the multidrug efflux system protein AcrA.", "Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex.", "Transporter excess and clustering facilitate adaptor protein shuttling for bacterial efflux." ]

[ 2006, 2020, 2025 ]

3

[]

0

null

[ "Bacteria", "Dickeya phage phiDP10.3", "Eukaryota", "Halorubrum tibetense", "Plasmid pMCBF1", "unclassified sequences" ]

[ 62623, 1, 76, 1, 1, 361 ]

6

[ "Escherichia coli (strain K12)" ]

[ 7 ]

1

true

Domain

Multidrug resistance protein MdtA-like, alpha-helical hairpin domain

MdtA-like_HH

4

IPR058626

58,626

Multidrug resistance protein MdtA-like, beta-barrel domain

MdtA-like_b-barrel

Domain

42,384

false

This domain is found in a group of bacterial periplasmic membrane fusion proteins (MFPs) that are components of the RND tripartite drug efflux pumps, including Multidrug resistance protein MdtA and Macrolide export protein MacA [ ] MFPs bridge the outer membrane factor and an inner membrane transporter. The most charac...

[]

0

[ "PFAM" ]

[ "PF25944" ]

[ "Beta-barrel_RND" ]

[ 42384 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9638334", "R-HSA-9760173", "R-HSA-9913143" ]

[ "REACTOME:R-HSA-9638334", "REACTOME:R-HSA-9760173", "REACTOME:R-HSA-9913143" ]

3

[ "1t5e", "1vf7", "2f1m", "2v4d", "3fpp", "5ng5", "5nik", "5nil", "5o66", "5v5s", "6iok", "6iol", "6ta5", "6ta6", "9j3d", "9j3e", "9v53", "9v55" ]

18

[ "PUB00040497", "PUB00161137", "PUB00161442", "PUB00161626" ]

[ "16531241", "26867482", "33009415", "40083904" ]

[ "Conformational flexibility in the multidrug efflux system protein AcrA.", "Tripartite assembly of RND multidrug efflux pumps.", "Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex.", "Transporter excess and clustering facilitate adaptor p...

[ 2006, 2016, 2020, 2025 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Plasmid pMCBF1", "unclassified sequences" ]

[ 42122, 58, 1, 203 ]

4

[ "Escherichia coli (strain K12)" ]

[ 5 ]

1

true

Domain

Multidrug resistance protein MdtA-like, beta-barrel domain

MdtA-like_b-barrel

1

IPR058627

58,627

Multidrug resistance protein MdtA-like, C-terminal permuted SH3 domain

MdtA-like_C

Domain

67,097

false

This domain is found in a group of bacterial periplasmic membrane fusion proteins (MFPs) that are components of the RND tripartite drug efflux pumps, including Multidrug resistance protein MdtA and Macrolide export protein MacA [ ]. MFPs bridge the outer membrane factor and an inner membrane transporter. The most chara...

[]

0

[ "PFAM" ]

[ "PF25967" ]

[ "RND-MFP_C" ]

[ 67097 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9638334", "R-HSA-9760173", "R-HSA-9913143" ]

[ "REACTOME:R-HSA-9638334", "REACTOME:R-HSA-9760173", "REACTOME:R-HSA-9913143" ]

3

[ "1t5e", "1vf7", "2v4d", "3fpp", "3lnn", "4dk0", "4dk1", "4l8j", "5ng5", "5nik", "5nil", "5o66", "5v5s", "6iok", "6iol", "6ta5", "6ta6", "6vej", "9j3d", "9j3e", "9v53", "9v55" ]

22

[ "PUB00040497", "PUB00161442", "PUB00161626" ]

[ "16531241", "33009415", "40083904" ]

[ "Conformational flexibility in the multidrug efflux system protein AcrA.", "Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex.", "Transporter excess and clustering facilitate adaptor protein shuttling for bacterial efflux." ]

[ 2006, 2020, 2025 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 66531, 70, 496 ]

3

[ "Escherichia coli (strain K12)" ]

[ 5 ]

1

true

Domain

Multidrug resistance protein MdtA-like, C-terminal permuted SH3 domain

MdtA-like_C

3

IPR058628

58,628

Multidrug efflux pump subunit AcrA

AcrA

Family

739

false

This entry represents Multidrug efflux pump subunit AcrA from Escherichia coli and similar proteins found in enterobacterales. AcrA is the periplasmic adaptor component of the AcrAB-TolC efflux system that confers multidrug resistance [ ]. AcrA is elongated in shape, being long enough to span the periplasm, linking Acr...

[]

0

[ "NCBIFAM" ]

[ "NF011604" ]

[ "PRK15030.1" ]

[ 739 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9638334", "R-HSA-9760173", "R-HSA-9913143" ]

[ "REACTOME:R-HSA-9638334", "REACTOME:R-HSA-9760173", "REACTOME:R-HSA-9913143" ]

3

[ "5ng5", "5o66", "5v5s", "9v53", "9v55" ]

5

[ "PUB00074175", "PUB00161073", "PUB00161629", "PUB00161630" ]

[ "23010927", "28355133", "22308040", "9878415" ]

[ "Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance.", "An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump.", "Assembly and channel opening of outer membrane protein in tripartite drug efflux pumps of Gram-negative bact...

[ 2012, 2017, 2012, 1999 ]

4

[ "IPR006143" ]

[]

1

0

1

[ "Pseudomonadati" ]

[ 739 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Multidrug efflux pump subunit AcrA

AcrA

4

IPR058629

58,629

Dihydropteroate synthase type-3

Sul3

Family

69

false

This entry represents Dihydropteroate synthase type-3 from Escherichia coli (Sul3) and similar sequences from gammaproteobacteria. Sul3 catalyses the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of fol...

[]

0

[ "NCBIFAM" ]

[ "NF000296" ]

[ "Sul3" ]

[ 69 ]

1

[]

0

[ "7s2l", "7s2m", "8scd" ]

3

[ "PUB00161002", "PUB00161631" ]

[ "37419898", "12604565" ]

[ "Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.", "A new sulfonamide resistance gene (sul3) in Escherichia coli is widespread in the pig population of Switzerland." ]

[ 2023, 2003 ]

2

[ "IPR045031" ]

[]

1

0

1

[ "Bacteria", "Punavirus P1" ]

[ 68, 1 ]

2

[]

0

true

Family

Dihydropteroate synthase type-3

Sul3

6

IPR058630

58,630

Phage T4, Y16D

T4_Y16D

Family

521

false

This entry represents a family of phage proteins an prophages mainly found in proteobacteria that includes Uncharacterized 17.8 kDa protein in arn-motA intergenic region (Y16D) from phage T4. This protein is predicted to form a homodimer, with a monomer composed of a pair of N-terminal α-helices followed by a domain co...

[]

0

[ "PFAM" ]

[ "PF26092" ]

[ "T4_Y16D" ]

[ 521 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 110, 402, 9 ]

3

[]

0

true

Family

Phage T4, Y16D

T4_Y16D

1