interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR058631 | 58,631 | Teashirt homolog 1-3-like, homeodomain | TSHZ1-3_homeodomain | Domain | 2,709 | false | false | This entry represents the homeodomain of human Teashirt homolog 3 (TSHZ3) and similar proteins from vertebrates. TSHZ3 is a transcriptional regulator involved in developmental processes. It associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) [ ]. This domain is often found associat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26094"
] | [
"HTH_TSHZ3"
] | [
2709
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00061839",
"PUB00061840",
"PUB00061841",
"PUB00061842",
"PUB00161292",
"PUB00161293",
"PUB00161294"
] | [
"14973285",
"20631175",
"18776146",
"19745106",
"19343227",
"10704881",
"27668656"
] | [
"Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.",
"Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control.",
"Teashirt 3 is necessary for ureteral smooth muscle differentiation downst... | [
2004,
2010,
2008,
2010,
2009,
2000,
2016
] | 7 | [
"IPR001356"
] | [] | 1 | 0 | 1 | [
"Chordata"
] | [
2709
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
7,
16,
14
] | 4 | true | Domain | Teashirt homolog 1-3-like, homeodomain | Teashirt homolog 1-3-like, homeodomain | TSHZ1-3_homeodomain | 2 |
IPR058632 | 58,632 | p-hydroxybenzoic acid efflux pump subunit AaeA, alpha-helical hairpin domain | HH_AaeA | Domain | 1,514 | false | false | This entry represents the α-helical hairpin domain found in p-hydroxybenzoic acid efflux pump subunit AaeA, which is a component of the p-hydroxybenzoic acid (pHBA) efflux pump in Escherichia coli [ ]. It forms an efflux pump with AaeB, which functions to export certain aromatic carboxylic acids from the cell. The AaeA... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25878"
] | [
"HH_AAEA_pHBA"
] | [
1514
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054183"
] | [
"15489430"
] | [
"Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve?"
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Pseudomonadati",
"mine drainage metagenome"
] | [
2,
1511,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | p-hydroxybenzoic acid efflux pump subunit AaeA, alpha-helical hairpin domain | p-hydroxybenzoic acid efflux pump subunit AaeA, alpha-helical hairpin domain | HH_AaeA | 7 |
IPR058633 | 58,633 | Multidrug export protein EmrA/FarA, alpha-helical hairpin domain | EmrA/FarA_HH | Domain | 5,857 | false | false | This domain is found in the Multidrug export protein EmrA and related proteins, including its paralogue ErmK and Fatty acid resistance protein FarA. EmrA is a crucial component of the EmrAB-TolC efflux system in Escherichia coli, which plays a significant role in conferring resistance to various antibiotics and toxic c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25885"
] | [
"HH_EMRA"
] | [
5857
] | 1 | [] | [] | [] | 0 | [
"8zal",
"8zar"
] | 2 | [
"PUB00092686",
"PUB00104016",
"PUB00158923"
] | [
"12482849",
"19171121",
"10447892"
] | [
"Identification of oligomerization and drug-binding domains of the membrane fusion protein EmrA.",
"The multidrug resistance efflux complex, EmrAB from Escherichia coli forms a dimer in vitro.",
"The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids."
] | [
2003,
2009,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5814,
6,
37
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Multidrug export protein EmrA/FarA, alpha-helical hairpin domain | Multidrug export protein EmrA/FarA, alpha-helical hairpin domain | EmrA/FarA_HH | 9 |
IPR058635 | 58,635 | YhbJ, barrel-sandwich hybrid domain | BSH_YhbJ | Domain | 790 | false | false | This domain is found in the putative efflux system component YhbJ from Bacillus subtilis and related proteins mainly found in firmicutes. In contrast to the barrel-sandwich hybrid domains found in other efflux system components, this domain doesn't have a helical insertion but similarly it is inserted into a β-barrel w... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25997"
] | [
"BSH_YhbJ"
] | [
790
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"bioreactor metagenome"
] | [
788,
2
] | 2 | [] | [] | 0 | true | Domain | YhbJ, barrel-sandwich hybrid domain | YhbJ, barrel-sandwich hybrid domain | BSH_YhbJ | 8 |
IPR058636 | 58,636 | YknX-like, beta-barrel domain | Beta-barrel_YknX | Domain | 10,663 | false | false | This domain is found in the putative efflux system component YknX from Bacillus subtilis and related proteins. YknX is a component of an unusual four-component transporter YknWXYZ, which is required for protection against the killing factor SdpC (sporulation-delaying protein) [ ]. YknX interacts with YknYZ. The domain ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25990"
] | [
"Beta-barrel_YknX"
] | [
10663
] | 1 | [] | [] | [] | 0 | [
"5xu0"
] | 1 | [
"PUB00161138"
] | [
"22707703"
] | [
"YknWXYZ is an unusual four-component transporter with a role in protection against sporulation-delaying-protein-induced killing of Bacillus subtilis."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
10467,
9,
2,
185
] | 4 | [] | [] | 0 | true | Domain | YknX-like, beta-barrel domain | YknX-like, beta-barrel domain | Beta-barrel_YknX | 3 |
IPR058637 | 58,637 | YknX-like, C-terminal permuted SH3-like domain | YknX-like_C | Domain | 23,454 | false | false | This domain is found in the Putative efflux system component YknX from Bacillus subtilis and related bacterial proteins. YknX is a component of an unusual four-component transporter YknWXYZ, which is required for protection against the killing factor SdpC (sporulation-delaying protein) [ ]. YknX interacts with YknYZ. T... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25989"
] | [
"YknX_C"
] | [
23454
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161138"
] | [
"22707703"
] | [
"YknWXYZ is an unusual four-component transporter with a role in protection against sporulation-delaying-protein-induced killing of Bacillus subtilis."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Plasmid pMCBF1",
"Siphoviridae sp. ct3z32",
"unclassified sequences"
] | [
23114,
21,
1,
1,
317
] | 5 | [] | [] | 0 | true | Domain | YknX-like, C-terminal permuted SH3-like domain | YknX-like, C-terminal permuted SH3-like domain | YknX-like_C | 5 |
IPR058638 | 58,638 | YknX-like, alpha-helical hairpin domain | HH_YknX-like | Domain | 530 | false | false | This domain is found in the putative efflux system component YknX from Bacillus subtilis and related proteins from firmicutes. YknX is a component of an unusual four-component transporter YknWXYZ, which is required for protection against the killing factor SdpC (sporulation-delaying protein) [ ]. YknX interacts with Yk... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25982"
] | [
"HH_YknX"
] | [
530
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161138"
] | [
"22707703"
] | [
"YknWXYZ is an unusual four-component transporter with a role in protection against sporulation-delaying-protein-induced killing of Bacillus subtilis."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Sinanodonta woodiana"
] | [
529,
1
] | 2 | [] | [] | 0 | true | Domain | YknX-like, alpha-helical hairpin domain | YknX-like, alpha-helical hairpin domain | HH_YknX-like | 4 |
IPR058639 | 58,639 | YknX-like, barrel-sandwich hybrid domain | BSH_YknX-like | Domain | 2,820 | false | false | This domain is found in the putative efflux system component YknX from Bacillus subtilis and related proteins. YknX is a component of an unusual four-component transporter YknWXYZ, which is required for protection against the killing factor SdpC (sporulation-delaying protein) [ ]. YknX interacts with YknYZ. This barrel... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25984"
] | [
"BSH_YknX"
] | [
2820
] | 1 | [] | [] | [] | 0 | [
"5xu0"
] | 1 | [
"PUB00161138"
] | [
"22707703"
] | [
"YknWXYZ is an unusual four-component transporter with a role in protection against sporulation-delaying-protein-induced killing of Bacillus subtilis."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
2814,
6
] | 2 | [] | [] | 0 | true | Domain | YknX-like, barrel-sandwich hybrid domain | YknX-like, barrel-sandwich hybrid domain | BSH_YknX-like | 1 |
IPR058640 | 58,640 | Phage Phi812, Virion protein 5 | Phi812_Virion_protein_5 | Family | 247 | false | false | This entry represents Virion protein 5 of bacteriophage phi812 and related proteins. Phi812 is a bacteriophage that infects Staphylococcus aureus, including many methicillin-resistant strains (MRSA). This protein adopts an eight-stranded β-barrel fold with a protruding stacking loop, characteristic for tail tube protei... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26461"
] | [
"Phi812_tail_tube"
] | [
247
] | 1 | [] | [] | [] | 0 | [
"8q01",
"8qek",
"8r5g",
"8r69",
"9euf",
"9eug",
"9f04",
"9f06"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Sphagnum jensenii",
"Viruses",
"marine sediment metagenome"
] | [
34,
2,
208,
3
] | 4 | [] | [] | 0 | true | Family | Phage Phi812, Virion protein 5 | Phage Phi812, Virion protein 5 | Phi812_Virion_protein_5 | 7 |
IPR058641 | 58,641 | Interferon-induced very large GTPase 1 domain | GVIN1_dom | Domain | 2,940 | false | false | This domain is found in mouse Interferon-induced very large GTPase 1 (GVIN1 or VLIG-1) and similar proteins mainly found in vertebrates. Members of this group play a role in conserved immune functions [ , ]. This domain is predicted to adopt a mainly α structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25974"
] | [
"GVIN1"
] | [
2940
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00072540",
"PUB00161632"
] | [
"12874213",
"19369598"
] | [
"A giant GTPase, very large inducible GTPase-1, is inducible by IFNs.",
"The evolutionarily dynamic IFN-inducible GTPase proteins play conserved immune functions in vertebrates and cephalochordates."
] | [
2003,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Metazoa"
] | [
5,
2935
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
45,
1,
2,
2
] | 4 | true | Domain | Interferon-induced very large GTPase 1 domain | Interferon-induced very large GTPase 1 domain | GVIN1_dom | 7 |
IPR058642 | 58,642 | BRE1A/B-like domain | BRE1A/B-like_dom | Domain | 3,045 | false | false | This domain is found in human E3 ubiquitin-protein ligase BRE1A/B and similar animal proteins. This domain shows an α-helical configuration. BRE1A (known as RNF20) and BRE1B (known as RNF40) form a heterodimeric E3 ubiquitin ligase complex essential for monoubiquitinating histone H2B at lysine 120, a key epigenetic mar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26052"
] | [
"BRE1B"
] | [
3045
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-BTA-8866654",
"R-BTA-9013422",
"R-DME-8866654",
"R-DME-9013422",
"R-HSA-8866654",
"R-HSA-9013422",
"R-MMU-8866654",
"R-MMU-9013422",
"R-RNO-8866654"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-8866654",
"REACTOME:R-BTA-9013422",
"REACTOME:R-DME-8866654",
"REACTOME:R-DME-9013422",
"REACTOME:R-HSA-8866654",
"REACTOME:R-HSA-9013422",
"REACTOME:R-MMU-8866654",
"REACTOME:R-MMU-9013422",
"REACTOME:R-RNO-8866654"
] | 11 | [
"8gui",
"8guj"
] | 2 | [
"PUB00033272",
"PUB00135664",
"PUB00135665",
"PUB00135666",
"PUB00135675",
"PUB00147625",
"PUB00161150",
"PUB00161151",
"PUB00161152",
"PUB00161153",
"PUB00161154"
] | [
"16337599",
"15691768",
"19410543",
"19037095",
"16307923",
"28453857",
"37888983",
"25564623",
"12121982",
"31951376",
"38519511"
] | [
"The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions.",
"Bre1 is required for Notch signaling and histone modification.",
"RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.",
"Human BRE1 is a... | [
2005,
2005,
2009,
2009,
2005,
2017,
2023,
2015,
2002,
2020,
2024
] | 11 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
3045
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
2,
9,
5,
12
] | 6 | true | Domain | BRE1A/B-like domain | BRE1A/B-like domain | BRE1A/B-like_dom | 2 |
IPR058643 | 58,643 | BRE1-like, coiled-coil containing domain | BRE1-like_CC | Domain | 3,710 | false | false | This domain is found in the human paralogues E3 ubiquitin-protein ligase BRE1A and BRE1B, and related proteins from animals and fungi. The domain represented by this entry is predicted with high probability to contain at least two coiled-coil regions. BRE1A (known as RNF20) and BRE1B (known as RNF40) form a heterodimer... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26095"
] | [
"CC_Bre1"
] | [
3710
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-BTA-8866654",
"R-BTA-9013422",
"R-DME-8866654",
"R-DME-9013422",
"R-HSA-8866654",
"R-HSA-9013422",
"R-MMU-8866654",
"R-MMU-9013422",
"R-RNO-8866654"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-8866654",
"REACTOME:R-BTA-9013422",
"REACTOME:R-DME-8866654",
"REACTOME:R-DME-9013422",
"REACTOME:R-HSA-8866654",
"REACTOME:R-HSA-9013422",
"REACTOME:R-MMU-8866654",
"REACTOME:R-MMU-9013422",
"REACTOME:R-RNO-8866654"
] | 11 | [
"8gui",
"8guj"
] | 2 | [
"PUB00033272",
"PUB00135664",
"PUB00135665",
"PUB00135666",
"PUB00135675",
"PUB00161150",
"PUB00161152"
] | [
"16337599",
"15691768",
"19410543",
"19037095",
"16307923",
"37888983",
"12121982"
] | [
"The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions.",
"Bre1 is required for Notch signaling and histone modification.",
"RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.",
"Human BRE1 is a... | [
2005,
2005,
2009,
2009,
2005,
2023,
2002
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Hyperionvirus sp.",
"Methanomicrobia",
"metagenomes"
] | [
22,
3682,
1,
3,
2
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
2,
8,
5,
2,
10
] | 6 | true | Domain | BRE1-like, coiled-coil containing domain | BRE1-like, coiled-coil containing domain | BRE1-like_CC | 1 |
IPR058644 | 58,644 | Low molecular weight antigen MTB12-like, C-terminal domain | Mtb12-like_C | Domain | 2,901 | false | false | This domain is found at the C-terminal end of Low molecular weight antigen MTB12 from Mycobacterium tuberculosis, which may play a role in the development of protective immune responses. It shows a unique tertiary structure that consists of four β-strands and four α-helices [ ]. This group is specific to actinomycetes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26580"
] | [
"Mtb12_C"
] | [
2901
] | 1 | [] | [] | [] | 0 | [
"8z9b"
] | 1 | [
"PUB00161360"
] | [
"38718566"
] | [
"Novel structure of secreted small molecular weight antigen Mtb12 from Mycobacterium tuberculosis."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
2887,
14
] | 2 | [] | [] | 0 | true | Domain | Low molecular weight antigen MTB12-like, C-terminal domain | Low molecular weight antigen MTB12-like, C-terminal domain | Mtb12-like_C | 9 |
IPR058645 | 58,645 | NTF2-like domain | NTF2-like_dom_7 | Domain | 1,277 | false | false | This entry represents a domain found in a family of uncharacterised proteins from ascomycetes. The typical length of the proteins in this group is around 150-200 amino acids. This domain belongs to the NTF2-like superfamily ( ), characterised by a partial β-barrel structure with α-helices enclosing a solvent-accessible... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26534"
] | [
"NTF2_7"
] | [
1277
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1277
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | NTF2-like domain | NTF2-like domain | NTF2-like_dom_7 | 1 |
IPR058646 | 58,646 | CzcB, N-terminal domain | CzcB_N | Domain | 1,138 | false | false | This domain is found N-terminal in the Cobalt-zinc-cadmium resistance protein CzcB and related proteins from proteobacteria. This domain can be found sometimes inserted in members of the Cation efflux family or in the NicO family of high-affinity nickel-transports . It is predicted to fold into a β-sandwich with an Ig-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25971"
] | [
"CzcB_N"
] | [
1138
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161159"
] | [
"9371429"
] | [
"New functions for the three subunits of the CzcCBA cation-proton antiporter."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1111,
6,
21
] | 3 | [] | [] | 0 | true | Domain | CzcB, N-terminal domain | CzcB, N-terminal domain | CzcB_N | 6 |
IPR058647 | 58,647 | CzcB-like, barrel-sandwich hybrid domain | BSH_CzcB-like | Domain | 25,322 | false | false | This domain is found in the Cobalt-zinc-cadmium resistance protein CzcB, its paralogue Nickel and cobalt resistance protein CnrB from Cupriavidus metallidurans and related bacterial proteins. CzcB is a crucial component of the CzcCBA protein complex, which mediates heavy metal resistance in bacteria through an active c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25973"
] | [
"BSH_CzcB"
] | [
25322
] | 1 | [] | [] | [] | 0 | [
"3lnn",
"4tko"
] | 2 | [
"PUB00161159"
] | [
"9371429"
] | [
"New functions for the three subunits of the CzcCBA cation-proton antiporter."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
24929,
33,
360
] | 3 | [] | [] | 0 | true | Domain | CzcB-like, barrel-sandwich hybrid domain | CzcB-like, barrel-sandwich hybrid domain | BSH_CzcB-like | 6 |
IPR058648 | 58,648 | CzcB-like, alpha-helical hairpin domain | HH_CzcB-like | Domain | 4,540 | false | false | This domain is found in the Cobalt-zinc-cadmium resistance protein CzcB, its paralogue Nickel and cobalt resistance protein CnrB from Cupriavidus metallidurans and related bacterial proteins. CzcB is a crucial component of the CzcCBA protein complex, which mediates heavy metal resistance in bacteria through an active c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25893"
] | [
"HH_CzcB"
] | [
4540
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161159"
] | [
"9371429"
] | [
"New functions for the three subunits of the CzcCBA cation-proton antiporter."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4481,
14,
45
] | 3 | [] | [] | 0 | true | Domain | CzcB-like, alpha-helical hairpin domain | CzcB-like, alpha-helical hairpin domain | HH_CzcB-like | 9 |
IPR058649 | 58,649 | CzcB-like, C-terminal circularly permuted SH3-like domain | CzcB_C | Domain | 16,375 | false | false | This domain is found in the Cobalt-zinc-cadmium resistance protein CzcB, its paralogue Nickel and cobalt resistance protein CnrB from Cupriavidus metallidurans and related bacterial proteins. The domain represented by this entry folds into an open barrel with a circularly permuted topology of SH3-like barrels. CzcB is ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25975"
] | [
"CzcB_C"
] | [
16375
] | 1 | [] | [] | [] | 0 | [
"5a4g"
] | 1 | [
"PUB00161159"
] | [
"9371429"
] | [
"New functions for the three subunits of the CzcCBA cation-proton antiporter."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanolliviera hydrocarbonicum",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
16072,
1,
29,
1,
272
] | 5 | [] | [] | 0 | true | Domain | CzcB-like, C-terminal circularly permuted SH3-like domain | CzcB-like, C-terminal circularly permuted SH3-like domain | CzcB_C | 6 |
IPR058650 | 58,650 | Mechanosensitive ion channel protein Msy1/2-like, transmembrane domain | Msy1/2-like | Domain | 4,096 | false | false | This domain is found in Mechanosensitive ion channel protein Msy1/2 from Schizosaccharomyces pombe, Mechanosensitive ion channel protein 9/10 from Arabidopsis thaliana (MSL9/10), and similar sequences from fungi and plants. Msy1 regulates intracellular calcium levels and cell volume for survival in response to hypo-osm... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25886"
] | [
"Msy1"
] | [
4096
] | 1 | [] | [] | [] | 0 | [
"8jwe",
"8tdj",
"8tdk",
"8tdl",
"8tdm"
] | 5 | [
"PUB00057878",
"PUB00057879",
"PUB00089654",
"PUB00097362",
"PUB00161350"
] | [
"19704841",
"18485707",
"22910366",
"25041276",
"35941834"
] | [
"AtMSL9 and AtMSL10: Sensors of plasma membrane tension in Arabidopsis roots.",
"Two MscS homologs provide mechanosensitive channel activities in the Arabidopsis root.",
"Organellar mechanosensitive channels in fission yeast regulate the hypo-osmotic shock response.",
"Mechanosensitive channels Msy1 and Msy2 ... | [
2008,
2008,
2012,
2014,
2022
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4096
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
8,
2,
2,
1
] | 4 | true | Domain | Mechanosensitive ion channel protein Msy1/2-like, transmembrane domain | Mechanosensitive ion channel protein Msy1/2-like, transmembrane domain | Msy1/2-like | 7 |
IPR058651 | 58,651 | vWA-MoxR associated protein, N-terminal HTH domain | HTH_VMAP-M9 | Domain | 2,244 | false | false | This entry represents the N-terminal helix-turn-helix (HTH) domain of the vWA-MoxR associated protein (VMAP) of the classical ternary system (vWA-MoxR-VMAP) in NTP-dependent conflict systems. VMAP-Ms may be involved in sensing of invasive entities [ ]. Members of this group are mainly found in cyanobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26355"
] | [
"HTH_VMAP-M9"
] | [
2244
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098776"
] | [
"32101166"
] | [
"Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
2244
] | 1 | [] | [] | 0 | true | Domain | vWA-MoxR associated protein, N-terminal HTH domain | vWA-MoxR associated protein, N-terminal HTH domain | HTH_VMAP-M9 | 5 |
IPR058654 | 58,654 | Cell wall alpha-1,3-glucan synthase Mok11-14/Ags1-like, transmembrane domain | Mok11-14/Ags1-like_TM | Domain | 1,883 | false | false | This domain is found in the family of fungal cell wall alpha-1,3-glucan synthase enzymes such as Mok11, Mok12, Mok13, Mok14 and Ags1. The domain represented by this entry is predicted to contain twelve transmembrane helices. Mok11, Mok12, Mok13 and Ags1 are involved in the biosynthesis of alpha-1,3-glucan, a key struct... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26127"
] | [
"12TM_Mok13"
] | [
1883
] | 1 | [
"EC"
] | [
"2.4.1.183"
] | [
"EC:2.4.1.183"
] | 1 | [] | 0 | [
"PUB00116318",
"PUB00161107",
"PUB00161633"
] | [
"10087262",
"17472966",
"16420355"
] | [
"Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.",
"Role of the synthase domain of Ags1p in cell wall alpha-glucan biosynthesis in fission yeast.",
"Synthesis of al... | [
1999,
2007,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
1883
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
5
] | 2 | true | Domain | Cell wall alpha-1,3-glucan synthase Mok11-14/Ags1-like, transmembrane domain | Cell wall alpha-1,3-glucan synthase Mok11-14/Ags1-like, transmembrane domain | Mok11-14/Ags1-like_TM | 4 |
IPR058655 | 58,655 | Cell wall alpha-1,3-glucan synthase Mok11-14/Ags1-like | Mok11-14/Ags1-like | Family | 2,254 | false | false | This family of fungal cell wall alpha-1,3-glucan synthase enzymes includes Mok11, Mok12, Mok13, Mok14 and Ags1. Mok11, Mok12, Mok13 and Ags1 are involved in the biosynthesis of alpha-1,3-glucan, a key structural polysaccharide in fungal cell walls. They play critical roles in maintaining cell integrity, morphology, and... | [
"GO:0047657",
"GO:0070600"
] | [
"alpha-1,3-glucan synthase activity",
"fungal-type cell wall (1->3)-alpha-glucan biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR47182"
] | [
""
] | [
2254
] | 1 | [
"EC"
] | [
"2.4.1.183"
] | [
"EC:2.4.1.183"
] | 1 | [] | 0 | [
"PUB00116318",
"PUB00161107",
"PUB00161633"
] | [
"10087262",
"17472966",
"16420355"
] | [
"Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.",
"Role of the synthase domain of Ags1p in cell wall alpha-glucan biosynthesis in fission yeast.",
"Synthesis of al... | [
1999,
2007,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Vallitalea"
] | [
2251,
3
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
5
] | 2 | true | Family | Cell wall alpha-1,3-glucan synthase Mok11-14/Ags1-like | Cell wall alpha-1,3-glucan synthase Mok11-14/Ags1-like | Mok11-14/Ags1-like | 7 |
IPR058656 | 58,656 | Mok11-13/Ags1-like, GH beta-sandwich domain | Mok11-13/Ags1-like_GH | Domain | 1,838 | false | false | This domain is found in the family of fungal cell wall alpha-1,3-glucan synthase enzymes such as Mok11, Mok12, Mok13 and Ags1. The domain represented by this entry has a remote similarity to the C-terminal domain of fungal amylases and is predicted to adopt a similar structure. Mok11, Mok12, Mok13 and Ags1 are involved... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26108"
] | [
"GH_Mok13"
] | [
1838
] | 1 | [
"EC"
] | [
"2.4.1.183"
] | [
"EC:2.4.1.183"
] | 1 | [] | 0 | [
"PUB00116318",
"PUB00161107",
"PUB00161633"
] | [
"10087262",
"17472966",
"16420355"
] | [
"Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.",
"Role of the synthase domain of Ags1p in cell wall alpha-glucan biosynthesis in fission yeast.",
"Synthesis of al... | [
1999,
2007,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
1838
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
4
] | 2 | true | Domain | Mok11-13/Ags1-like, GH beta-sandwich domain | Mok11-13/Ags1-like, GH beta-sandwich domain | Mok11-13/Ags1-like_GH | 1 |
IPR058657 | 58,657 | Mok11-13/Ags1-like, Ig-like beta-sandwich domain | Mok11-13/Ags1-like_Ig | Domain | 1,840 | false | false | This domain is found in the family of fungal cell wall alpha-1,3-glucan synthase enzymes such as Mok11, Mok12, Mok13 and Ags1. The domain represented by this entry has a detectable similarity to known Ig-like domains and share common structural features with them, in particular with PapD-like domains. Mok11, Mok12, Mok... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26111"
] | [
"Ig_Mok13"
] | [
1840
] | 1 | [
"EC"
] | [
"2.4.1.183"
] | [
"EC:2.4.1.183"
] | 1 | [] | 0 | [
"PUB00116318",
"PUB00161107",
"PUB00161633"
] | [
"10087262",
"17472966",
"16420355"
] | [
"Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.",
"Role of the synthase domain of Ags1p in cell wall alpha-glucan biosynthesis in fission yeast.",
"Synthesis of al... | [
1999,
2007,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Fungi",
"Vallitalea longa"
] | [
1839,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
4
] | 2 | true | Domain | Mok11-13/Ags1-like, Ig-like beta-sandwich domain | Mok11-13/Ags1-like, Ig-like beta-sandwich domain | Mok11-13/Ags1-like_Ig | 9 |
IPR058658 | 58,658 | Mok11-13/Ags1-like, second Ig-like beta-sandwich domain | Mok11-13/Ags1-like_Ig_2 | Domain | 1,839 | false | false | This domain is found in the family of fungal cell wall alpha-1,3-glucan synthase enzymes such as Mok11, Mok12, Mok13 and Ags1. The domain represented by this entry has a detectable similarity to known Ig-like domains and is predicted to adopt a similar structure. Mok11, Mok12, Mok13 and Ags1 are involved in the biosynt... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26114"
] | [
"Ig_2_Mok13"
] | [
1839
] | 1 | [
"EC"
] | [
"2.4.1.183"
] | [
"EC:2.4.1.183"
] | 1 | [] | 0 | [
"PUB00116318",
"PUB00161107",
"PUB00161633"
] | [
"10087262",
"17472966",
"16420355"
] | [
"Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.",
"Role of the synthase domain of Ags1p in cell wall alpha-glucan biosynthesis in fission yeast.",
"Synthesis of al... | [
1999,
2007,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Fungi",
"Vallitalea"
] | [
1836,
3
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
4
] | 2 | true | Domain | Mok11-13/Ags1-like, second Ig-like beta-sandwich domain | Mok11-13/Ags1-like, second Ig-like beta-sandwich domain | Mok11-13/Ags1-like_Ig_2 | 7 |
IPR058659 | 58,659 | Mok11-13/Ags1-like, CBM domain | Mok11-13/Ags1-like_CBM | Domain | 1,836 | false | false | This domain is found in the family of fungal cell wall alpha-1,3-glucan synthase enzymes such as Mok11, Mok12, Mok13 and Ags1. The domain represented by this entry has detectable similarity to the starch specific domains of SusE/SusF outer membrane proteins and it is predicted to adopt a similar structure. Mok11, Mok12... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26122"
] | [
"CBM_Mok13"
] | [
1836
] | 1 | [
"EC"
] | [
"2.4.1.183"
] | [
"EC:2.4.1.183"
] | 1 | [] | 0 | [
"PUB00116318",
"PUB00161107",
"PUB00161633"
] | [
"10087262",
"17472966",
"16420355"
] | [
"Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function.",
"Role of the synthase domain of Ags1p in cell wall alpha-glucan biosynthesis in fission yeast.",
"Synthesis of al... | [
1999,
2007,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
1836
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
4
] | 2 | true | Domain | Mok11-13/Ags1-like, CBM domain | Mok11-13/Ags1-like, CBM domain | Mok11-13/Ags1-like_CBM | 5 |
IPR058660 | 58,660 | Replicative helicase loading/DNA remodeling protein DnaB, N-terminal winged helix domain | WHD_DnaB | Domain | 3,817 | false | false | This entry represents the N-terminal winged helix domain (WHD) of Replicative helicase loading/DNA remodeling protein DnaB from Bacillus subtilis and similar sequences mainly found in firmicutes. DnaB is involved in both the initiation of replication at oriC and in replication restart of stalled replication forks as pa... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25888"
] | [
"WHD_DnaB"
] | [
3817
] | 1 | [] | [] | [] | 0 | [
"5wtn"
] | 1 | [
"PUB00009584",
"PUB00013071",
"PUB00160774",
"PUB00160776",
"PUB00161522",
"PUB00161634",
"PUB00161635"
] | [
"11679082",
"3027697",
"12718886",
"19968790",
"3027671",
"15686560",
"32817095"
] | [
"DnaB, DnaD and DnaI proteins are components of the Bacillus subtilis replication restart primosome.",
"Nucleotide sequence of Bacillus subtilis dnaB: a gene essential for DNA replication initiation and membrane attachment.",
"A two-protein strategy for the functional loading of a cellular replicative DNA helic... | [
2001,
1987,
2003,
2010,
1986,
2005,
2020
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Zophobas morio",
"human gut metagenome"
] | [
3812,
1,
4
] | 3 | [] | [] | 0 | true | Domain | Replicative helicase loading/DNA remodeling protein DnaB, N-terminal winged helix domain | Replicative helicase loading/DNA remodeling protein DnaB, N-terminal winged helix domain | WHD_DnaB | 6 |
IPR058661 | 58,661 | Scaffold protein FimL, second domain | FimL_2nd | Domain | 2,825 | false | false | This entry represents the second domain of Scaffold protein FimL from Pseudomonas aeruginosa and similar proteins from proteobacteria. FimL is involved in the regulation of various virulence functions in bacteria, including the assembly of type IV pili (T4P) and twitching motility [ ]. It plays a crucial role in contro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26379"
] | [
"FimL_2nd"
] | [
2825
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161228",
"PUB00161229",
"PUB00161230"
] | [
"15720546",
"21264306",
"27145134"
] | [
"Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways.",
"FimL regulates cAMP synthesis in Pseudomonas aeruginosa.",
"A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas ae... | [
2005,
2011,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"Sar",
"metagenomes"
] | [
2777,
2,
46
] | 3 | [] | [] | 0 | true | Domain | Scaffold protein FimL, second domain | Scaffold protein FimL, second domain | FimL_2nd | 5 |
IPR058662 | 58,662 | Unconventional myosin-Va/b domain | Myo5a/b_dom | Domain | 4,128 | false | false | This domain is found in mouse Unconventional myosin-Va/b (Myo5a/b) and similar sequences mainly found in animals. Myo5a is a processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. This protein is involved in melanosome transport and mediates the transport ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25966"
] | [
"Myo5a"
] | [
4128
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1445148",
"R-HSA-2029482",
"R-HSA-264876",
"R-HSA-432040",
"R-HSA-9664422",
"R-HSA-9824585",
"R-MMU-2029482",
"R-MMU-432040",
"R-MMU-9824585",
"R-RNO-2029482",
"R-RNO-432040",
"R-RNO-9824585"
] | [
"REACTOME:R-HSA-1445148",
"REACTOME:R-HSA-2029482",
"REACTOME:R-HSA-264876",
"REACTOME:R-HSA-432040",
"REACTOME:R-HSA-9664422",
"REACTOME:R-HSA-9824585",
"REACTOME:R-MMU-2029482",
"REACTOME:R-MMU-432040",
"REACTOME:R-MMU-9824585",
"REACTOME:R-RNO-2029482",
"REACTOME:R-RNO-432040",
"REACTOME:R-... | 12 | [
"7yv9"
] | 1 | [
"PUB00132155",
"PUB00161363",
"PUB00161364",
"PUB00161365",
"PUB00161366",
"PUB00161367",
"PUB00161368",
"PUB00161369",
"PUB00161370",
"PUB00161636"
] | [
"19812310",
"22908308",
"10448864",
"17462998",
"19542231",
"21206382",
"21282656",
"28027573",
"36490350",
"34816459"
] | [
"Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling.",
"Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes.",
"Myosin-V is a processive actin-based motor.",
"Myosin Vb is required for trafficking of the cystic f... | [
2009,
2012,
1999,
2007,
2009,
2011,
2011,
2017,
2022,
2022
] | 10 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4128
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
34,
27,
10,
18
] | 4 | true | Domain | Unconventional myosin-Va/b domain | Unconventional myosin-Va/b domain | Myo5a/b_dom | 4 |
IPR058663 | 58,663 | PucR-like, N-terminal domain | PucR-like_N | Domain | 3,072 | false | false | This entry describes a domain of unknown function found at the N-terminal of putative PucR-like transcriptional regulators from actinomycetes. It is often found associated with which is located at the C-terminal. This domain is predicted to contain a globin-like domain structure. The globin fold typically consists of e... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25906"
] | [
"PucR-like_N"
] | [
3072
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00035871"
] | [
"15598493"
] | [
"Structural and functional properties of hemoglobins from unicellular organisms as revealed by resonance Raman spectroscopy."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetota",
"freshwater metagenome"
] | [
3071,
1
] | 2 | [] | [] | 0 | true | Domain | PucR-like, N-terminal domain | PucR-like, N-terminal domain | PucR-like_N | 4 |
IPR058664 | 58,664 | Beta-lactamase-like ARB_00930-like, C-terminal domain | ARB_00930-like_C | Domain | 3,147 | false | false | This domain is found at the C-terminal end of a group of functionally uncharacterised proteins from ascomycetes, including Beta-lactamase-like protein ARB_00930 from Arthroderma benhamiae. This domain, which is predicted to adopt an α-β configuration, is often found associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26335"
] | [
"ARB_00930_C"
] | [
3147
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3147
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | Beta-lactamase-like ARB_00930-like, C-terminal domain | Beta-lactamase-like ARB_00930-like, C-terminal domain | ARB_00930-like_C | 4 |
IPR058666 | 58,666 | SASH1/NUB1, homeodomain-like domain | SASH1/NUB1_homeodomain | Domain | 3,362 | false | false | This small domain is found at the N-terminal end in human SAM and SH3 domain-containing protein 1 (SASH1) and NEDD8 ultimate buster 1(NUB1) and similar animal proteins. The function of this domain is unknown, however it shows some structural similarity to the homeodomain suggesting a potential DNA-binding function. SAS... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26285"
] | [
"SASH1_Homeodomain"
] | [
3362
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-8951664",
"R-MMU-8951664"
] | [
"REACTOME:R-HSA-8951664",
"REACTOME:R-MMU-8951664"
] | 2 | [
"8usb",
"8usc",
"8usd",
"9e8g",
"9e8h",
"9e8i",
"9e8j",
"9e8l"
] | 8 | [
"PUB00134613",
"PUB00161454",
"PUB00161455",
"PUB00161456"
] | [
"16707496",
"23333244",
"23776175",
"25315659"
] | [
"The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10.",
"SASH1 regulates melanocyte transepithelial migration through a novel Gαs-SASH1-IQGAP1-E-Cadherin dependent pathway.",
"SASH1 is a scaffold molecule in endothelial TLR4 signaling.",
"... | [
2006,
2013,
2013,
2015
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3362
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
31,
6,
11,
9,
17
] | 5 | true | Domain | SASH1/NUB1, homeodomain-like domain | SASH1/NUB1, homeodomain-like domain | SASH1/NUB1_homeodomain | 2 |
IPR058667 | 58,667 | DUF6242, beta-propeller domain | DUF6242_C | Domain | 1,289 | false | false | This entry represents the C-terminal β-propeller domain of a family of uncharacterised bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25852"
] | [
"DUF6242_C"
] | [
1289
] | 1 | [] | [] | [] | 0 | [
"4lgn",
"9his",
"9hj3"
] | 3 | [
"PUB00014861"
] | [
"11266614"
] | [
"Sialidase-like Asp-boxes: sequence-similar structures within different protein folds."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
1195,
7,
16,
9,
62
] | 5 | [] | [] | 0 | true | Domain | DUF6242, beta-propeller domain | DUF6242, beta-propeller domain | DUF6242_C | 8 |
IPR058668 | 58,668 | NERD domain | NERD_dom | Domain | 2,806 | false | false | This domain is found in Zinc finger CCCH domain-containing protein 19 (NERD) from Arabidopsis thaliana and similar plant proteins. NERD plays a central role in integrating RNA silencing and chromatin signals in the 21 nt siRNA-dependent DNA methylation on the cytosine pathway leading to transcriptional gene silencing o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25980"
] | [
"NERD_plant"
] | [
2806
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00142540"
] | [
"22940247"
] | [
"NERD, a plant-specific GW protein, defines an additional RNAi-dependent chromatin-based pathway in Arabidopsis."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
2806
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
22,
7,
89
] | 3 | true | Domain | NERD domain | NERD domain | NERD_dom | 3 |
IPR058669 | 58,669 | Importin-7/11-like, TPR repeats | TPR_IPO7/11-like | Domain | 11,270 | false | false | This region of tetratricopeptide (TPR)-like repeats is found at the C-terminal end of human Importin-7/11 and similar eukaryotic proteins. IPO7/11 function in nuclear protein import as nuclear transport receptors [ , , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25758"
] | [
"TPR_IPO11"
] | [
11270
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5578749",
"R-MMU-5578749"
] | [
"REACTOME:R-HSA-5578749",
"REACTOME:R-MMU-5578749"
] | 2 | [
"6fvb",
"6n1z",
"6n88",
"8f7a"
] | 4 | [
"PUB00100785",
"PUB00159905",
"PUB00160696",
"PUB00160731"
] | [
"34711951",
"30855230",
"30824373",
"11823430"
] | [
"AKIRIN2 controls the nuclear import of proteasomes in vertebrates.",
"Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone.",
"Fuzzy Interactions Form and Shape the Histone Transport Complex.",
"Importins fulfil a dual function as nuclear import receptors and cytoplasmic ... | [
2021,
2019,
2019,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
11270
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
19,
11,
7,
12,
11,
2,
11,
11,
1,
1,
51
] | 11 | true | Domain | Importin-7/11-like, TPR repeats | Importin-7/11-like, TPR repeats | TPR_IPO7/11-like | 1 |
IPR058670 | 58,670 | Phosphotyrosine protein phosphatase domain | PTPase_dom | Domain | 2,076 | false | false | This entry represents the Phosphotyrosine Protein Phosphatase PTPase domain from plant proteins, including Protein SEEDLING PLASTID DEVELOPMENT 1 from Arabidopsis thaliana (SPD1, ) and similar uncharacterised sequences from bacteria. While it shares limited sequence similarity with known plant protein tyrosine phosphat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25516"
] | [
"PTPase"
] | [
2076
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00035793",
"PUB00160662",
"PUB00160663",
"PUB00161637"
] | [
"9818190",
"26962298",
"32542989",
"21045120"
] | [
"Protein tyrosine phosphatases: mechanisms of catalysis and regulation.",
"Role of Protein Tyrosine Phosphatases in Plants.",
"Plant protein phosphatases: What do we know about their mechanism of action?",
"A mutation in Arabidopsis seedling plastid development1 affects plastid differentiation in embryo-deriv... | [
1998,
2015,
2021,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes",
"uncultured marine group II/III euryarchaeote AD1000_66_E09"
] | [
576,
1455,
44,
1
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
15,
6,
9
] | 3 | true | Domain | Phosphotyrosine protein phosphatase domain | Phosphotyrosine protein phosphatase domain | PTPase_dom | 6 |
IPR058672 | 58,672 | Putative restriction endonuclease, halobacteria | RE_put_halobact | Family | 74 | false | false | This entry represents a domain from a family of uncharacterised proteins mainly found in halobacteria. The proteins in this family are typically around 181 amino acids in length. The domain shows structural similarity to restriction endonucleases such as BglIIR. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26497"
] | [
"Halo_RE"
] | [
74
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"bioreactor metagenome"
] | [
19,
53,
2
] | 3 | [] | [] | 0 | true | Family | Putative restriction endonuclease, halobacteria | Putative restriction endonuclease, halobacteria | RE_put_halobact | 2 |
IPR058673 | 58,673 | HHO5-like, N-terminal domain | HHO5-like_N | Domain | 3,599 | false | false | This entry represents the N-terminal in a group of plant Myb family transcription factors from Arabidopsis thaliana, including HHO1-6, HRS1, and EFM. This domain is often found in association with , and predicted to adopt an all-α structure. Transcription Factor HHO5, which plays a role in regulating floral meristem ho... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26575"
] | [
"HHO5_N"
] | [
3599
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00097079",
"PUB00097080",
"PUB00097081",
"PUB00161268",
"PUB00161269",
"PUB00161270",
"PUB00161271"
] | [
"25723764",
"22545134",
"25132385",
"19341407",
"26903506",
"23324170",
"27016098"
] | [
"AtNIGT1/HRS1 integrates nitrate and phosphate signals at the Arabidopsis root tip.",
"HRS1 acts as a negative regulator of abscisic acid signaling to promote timely germination of Arabidopsis seeds.",
"A MYB-domain protein EFM mediates flowering responses to environmental cues in Arabidopsis.",
"Overexpressi... | [
2015,
2012,
2014,
2009,
2016,
2013,
2016
] | 7 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
3599
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
30,
12,
30
] | 3 | true | Domain | HHO5-like, N-terminal domain | HHO5-like, N-terminal domain | HHO5-like_N | 9 |
IPR058675 | 58,675 | DUF8054, C-terminal domain | DUF8054_C | Domain | 575 | false | false | This entry represents the small C-terminal β domain in putative proteins from halobacteria. This domain contains 6 highly conserved cysteines that form two putative zinc binding sites. This domain is associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26237"
] | [
"DUF8054_C"
] | [
575
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Halobacteriales"
] | [
2,
573
] | 2 | [] | [] | 0 | true | Domain | DUF8054, C-terminal domain | DUF8054, C-terminal domain | DUF8054_C | 4 |
IPR058676 | 58,676 | YuzK | YuzK | Family | 380 | false | false | This entry represents an uncharacterised protein family that includes the B. subtilis YuzK protein. This proteins contains and all-helical fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26149"
] | [
"YuzK"
] | [
380
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacilli"
] | [
380
] | 1 | [] | [] | 0 | true | Family | YuzK | YuzK | YuzK | 9 |
IPR058677 | 58,677 | Envelope protein, N-terminal domain | ORF4_N | Domain | 311 | false | false | This entry represents the N-terminal domain in envelope protein (Env/VP5) found in archaeal pleolipoviruses such as Halorubrum pleomorphic virus 1 (HRPV-1). This membrane fusion protein mediates viral entry by fusing the viral envelope with the host cell membrane [ ]. The protein has a unique V-shaped fold representing... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26255"
] | [
"Viral_env_HRPV"
] | [
311
] | 1 | [] | [] | [] | 0 | [
"6j7v",
"6qgi",
"6qgl"
] | 3 | [
"PUB00161513"
] | [
"30783086"
] | [
"The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Methanobacteriota",
"Trapavirae"
] | [
2,
288,
21
] | 3 | [] | [] | 0 | true | Domain | Envelope protein, N-terminal domain | Envelope protein, N-terminal domain | ORF4_N | 7 |
IPR058679 | 58,679 | RlmG, N-terminal domain | RlmG_N | Domain | 5,469 | false | false | This entry represents the N-terminal domain of Ribosomal RNA large subunit methyltransferase G (RlmG) and similar proteins mainly found in proteobacteria and actinomycetes. RlmG is a specific S-adenosylmethionine (AdoMet)-dependent methyltransferase responsible for N2-methylation of guanine at position 1835 (m2G1835) i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26049"
] | [
"RLMG_N"
] | [
5469
] | 1 | [
"EC"
] | [
"2.1.1.174"
] | [
"EC:2.1.1.174"
] | 1 | [
"4dcm"
] | 1 | [
"PUB00101544",
"PUB00101545"
] | [
"17010380",
"22753782"
] | [
"Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA.",
"Structural insights into the function of 23S rRNA methyltransferase RlmG (m²G1835) from Escherichia coli."
] | [
2006,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Protostomia",
"metagenomes"
] | [
5445,
3,
21
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | RlmG, N-terminal domain | RlmG, N-terminal domain | RlmG_N | 7 |
IPR058680 | 58,680 | SMAX1-like, nucleotide binding domain | NBD_SMAX1-like | Domain | 4,982 | false | false | This domain is found in Protein SUPPRESSOR OF MAX2 1 from Arabidopsis thaliana (SMAX1), a number of SMAX1-like proteins, Protein DWARF 53 from Oryza sativa, and similar sequences found in plants and some bacterial species. SMAX1 is thought to be a component of a transcriptional corepressor complex that acts downstream ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23569"
] | [
"NBD_SMAX1"
] | [
4982
] | 1 | [] | [] | [] | 0 | [
"9kkx",
"9kld",
"9klv"
] | 3 | [
"PUB00161108",
"PUB00161109",
"PUB00161110",
"PUB00161111",
"PUB00161112",
"PUB00161113"
] | [
"26546447",
"23893171",
"26546446",
"26754282",
"24336200",
"24336215"
] | [
"SMAX1-LIKE/D53 Family Members Enable Distinct MAX2-Dependent Responses to Strigolactones and Karrikins in Arabidopsis.",
"SUPPRESSOR OF MORE AXILLARY GROWTH2 1 controls seed germination and seedling development in Arabidopsis.",
"Strigolactone Signaling in Arabidopsis Regulates Shoot Development by Targeting D... | [
2015,
2013,
2015,
2016,
2013,
2013
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanomarinus sp.",
"Eukaryota",
"metagenomes"
] | [
751,
1,
4221,
9
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
39,
25,
35
] | 3 | true | Domain | SMAX1-like, nucleotide binding domain | SMAX1-like, nucleotide binding domain | NBD_SMAX1-like | 2 |
IPR058681 | 58,681 | Serine/threonine-protein kinase MEC1, HEAT repeats | HEAT_MEC1_N | Domain | 937 | false | false | This region of HEAT repeats is found at the N-terminal end of the yeast Serine/threonine-protein kinase MEC1 and similar proteins from ascomycetes. MEC1 activates checkpoint signalling upon genotoxic stresses such as ionising radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA d... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25385"
] | [
"HEAT_MEC1_N"
] | [
937
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [
"5x6o",
"6z2w",
"6z2x",
"6z3a",
"7wzr",
"7wzw"
] | 6 | [
"PUB00155649",
"PUB00160141"
] | [
"33169019",
"36175395"
] | [
"Mechanism of auto-inhibition and activation of Mec1<sup>ATR</sup> checkpoint kinase.",
"Structures of Mec1/ATR kinase endogenously stimulated by different genotoxins."
] | [
2021,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
937
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Serine/threonine-protein kinase MEC1, HEAT repeats | Serine/threonine-protein kinase MEC1, HEAT repeats | HEAT_MEC1_N | 2 |
IPR058682 | 58,682 | IRF-2BP1/2-like, middle domain | IRF-2BP1/2-like_M | Domain | 1,853 | false | false | This entry represents a domain found toward the central part of Interferon regulatory factor 2-binding protein 1 and 2 (IRF-2BP1/2) and their homologue IRF-2BP-like (also known as IRF-2BPL or C14orf4). These proteins are nuclear transcriptional repressors that bind to the C-terminal repression domain of IRF-2 and can i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25457"
] | [
"IRF-2BP1_2_M"
] | [
1853
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053789",
"PUB00097578",
"PUB00097579"
] | [
"12799427",
"30057031",
"27016798"
] | [
"Identification of novel co-repressor molecules for Interferon Regulatory Factor-2.",
"IRF2BPL Is Associated with Neurological Phenotypes.",
"Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder."
] | [
2003,
2018,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Metazoa",
"Pseudoalteromonas lipolytica"
] | [
1851,
2
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
3,
6
] | 4 | true | Domain | IRF-2BP1/2-like, middle domain | IRF-2BP1/2-like, middle domain | IRF-2BP1/2-like_M | 3 |
IPR058683 | 58,683 | TP_1001-like, C-terminal domain | TP_1001-like_C | Domain | 161 | false | false | This entry represents the C-terminal β-sandwich domain found in the uncharacterised Treponema pallidum TP_1001 lipoprotein. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26342"
] | [
"TP_1001_2nd"
] | [
161
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
156,
5
] | 2 | [] | [] | 0 | true | Domain | TP_1001-like, C-terminal domain | TP_1001-like, C-terminal domain | TP_1001-like_C | 7 |
IPR058684 | 58,684 | YopA, central domain | YopA_M | Domain | 237 | false | false | This entry represents the central domain found in the SPbeta prophage-derived uncharacterized protein YopA ( ). The function of this protein is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26308"
] | [
"YopA_M"
] | [
237
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillus phage SPbeta",
"Bacteria",
"Methanomicrobia",
"metagenomes"
] | [
1,
228,
4,
4
] | 4 | [] | [] | 0 | true | Domain | YopA, central domain | YopA, central domain | YopA_M | 7 |
IPR058686 | 58,686 | NPHP4, Ig-like domain 3 | Ig_NPHP4_3rd | Domain | 1,363 | false | false | This entry represents the third Ig-like domain in NPHP4 and related eukaryotic proteins. NPHP4 is involved in the organisation of apical junctions and the subapical actin network in multiciliated epithelial cells. It plays a crucial role in building functional cilia and is part of a proposed NPHP1-4-8 module. It is imp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26015"
] | [
"Ig_NPH4_3rd"
] | [
1363
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2028269",
"R-HSA-5620912",
"R-MMU-2028269",
"R-MMU-5620912"
] | [
"REACTOME:R-HSA-2028269",
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-2028269",
"REACTOME:R-MMU-5620912"
] | 4 | [] | 0 | [
"PUB00070859",
"PUB00129248"
] | [
"15661758",
"21357692"
] | [
"Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes.",
"Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia."
] | [
2005,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1363
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
2,
4,
4
] | 4 | true | Domain | NPHP4, Ig-like domain 3 | NPHP4, Ig-like domain 3 | Ig_NPHP4_3rd | 4 |
IPR058687 | 58,687 | NPHP4, Ig-like domain 1 | Ig_NPHP4_1st | Domain | 1,351 | false | false | This entry represents the first Ig-like domain in NPHP4 and related eukaryotic proteins. NPHP4 is involved in the organisation of apical junctions and the subapical actin network in multiciliated epithelial cells. It plays a crucial role in building functional cilia and is part of a proposed NPHP1-4-8 module. It is imp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26190"
] | [
"Ig_NPHP4_1st"
] | [
1351
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2028269",
"R-HSA-5620912",
"R-MMU-2028269",
"R-MMU-5620912"
] | [
"REACTOME:R-HSA-2028269",
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-2028269",
"REACTOME:R-MMU-5620912"
] | 4 | [] | 0 | [
"PUB00070859",
"PUB00074744",
"PUB00129248"
] | [
"15661758",
"16339905",
"21357692"
] | [
"Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes.",
"Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations.",
"Nephrocystin-4 regulates Pyk2-induced... | [
2005,
2005,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1351
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
3,
4,
4
] | 5 | true | Domain | NPHP4, Ig-like domain 1 | NPHP4, Ig-like domain 1 | Ig_NPHP4_1st | 8 |
IPR058688 | 58,688 | NPHP4, Ig-like domain 2 | Ig_NPHP4_2nd | Domain | 1,288 | false | false | This entry represents the second Ig-like domain in NPHP4 and related eukaryotic proteins. NPHP4 is involved in the organisation of apical junctions and the subapical actin network in multiciliated epithelial cells. It plays a crucial role in building functional cilia and is part of a proposed NPHP1-4-8 module. It is im... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26189"
] | [
"Ig_NPHP4_2nd"
] | [
1288
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2028269",
"R-HSA-5620912",
"R-MMU-2028269",
"R-MMU-5620912"
] | [
"REACTOME:R-HSA-2028269",
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-2028269",
"REACTOME:R-MMU-5620912"
] | 4 | [] | 0 | [
"PUB00070859",
"PUB00074744",
"PUB00129248"
] | [
"15661758",
"16339905",
"21357692"
] | [
"Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes.",
"Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations.",
"Nephrocystin-4 regulates Pyk2-induced... | [
2005,
2005,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1288
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
3,
4,
4
] | 4 | true | Domain | NPHP4, Ig-like domain 2 | NPHP4, Ig-like domain 2 | Ig_NPHP4_2nd | 1 |
IPR058689 | 58,689 | Lipid uptake coordinator A | LUCA | Family | 360 | false | false | Lipid uptake coordinator A (LUCA) is essential for the import of fatty acids and cholesterol, particularly during growth in macrophages and axenic culture. It plays a crucial role by stabilising the protein subunits of the Mce1 and Mce4 multi-subunit transporters, which are responsible for transporting fatty acids and ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26307"
] | [
"LUCA"
] | [
360
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161325"
] | [
"28708968"
] | [
"Rv3723/LucA coordinates fatty acid and cholesterol uptake in <i>Mycobacterium tuberculosis</i>."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
360
] | 1 | [] | [] | 0 | true | Family | Lipid uptake coordinator A | Lipid uptake coordinator A | LUCA | 9 |
IPR058690 | 58,690 | BrxE | BrxE | Family | 216 | false | false | This entry represents a family that includes the BrxE proteins found in both bacteria and archaea. These proteins range from 166 to 218 amino acids in length. BrxE is a protein of unknown function found in type 6 BREX phage resistance systems. | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF033447",
"PF26412"
] | [
"BrxE_fam",
"BrxE"
] | [
211,
214
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"leotiomyceta",
"mine drainage metagenome",
"uncultured Caudovirales phage"
] | [
195,
16,
2,
2,
1
] | 5 | [] | [] | 0 | true | Family | BrxE | BrxE | BrxE | 9 |
IPR058691 | 58,691 | SaeA, first Fn3-like domain | Fn3_SaeA_1st | Domain | 295 | false | false | This entry represents the first Fn3-like domain found in the ESX-1 scaffolding and assembly protein SaeA and similar proteins from actinomycetes. SaeA is involved in assembly of the ESX-1 secretion system (T7SS), which exports several proteins including EsxA and EsxB. The SaeA protein localises to the bacterial cell po... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25832"
] | [
"Fn3_SaeA_2nd"
] | [
295
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106782",
"PUB00161235"
] | [
"18554329",
"22233444"
] | [
"The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis.",
"Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria."
] | [
2008,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
295
] | 1 | [] | [] | 0 | true | Domain | SaeA, first Fn3-like domain | SaeA, first Fn3-like domain | Fn3_SaeA_1st | 1 |
IPR058692 | 58,692 | SaeA, second Fn3-like domain | Fn3_SaeA_2nd | Domain | 445 | false | false | This entry represents the second Fn3-like domain found in the ESX-1 scaffolding and assembly protein SaeA and similar bacterial proteins. SaeA is involved in assembly of the ESX-1 secretion system (T7SS), which exports several proteins including EsxA and EsxB. The SaeA protein localises to the bacterial cell pole and i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25833"
] | [
"Fn3_SaeA_3rd"
] | [
445
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106782",
"PUB00161235"
] | [
"18554329",
"22233444"
] | [
"The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis.",
"Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria."
] | [
2008,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"marine sediment metagenome"
] | [
443,
1,
1
] | 3 | [] | [] | 0 | true | Domain | SaeA, second Fn3-like domain | SaeA, second Fn3-like domain | Fn3_SaeA_2nd | 4 |
IPR058693 | 58,693 | SaeA, third Fn3-like domain | Fn3_SaeA_3rd | Domain | 229 | false | false | This entry represents the third Fn3-like domain found in the ESX-1 scaffolding and assembly protein SaeA and similar proteins from actinomycetes. SaeA is involved in assembly of the ESX-1 secretion system (T7SS), which exports several proteins including EsxA and EsxB. The SaeA protein localises to the bacterial cell po... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25834"
] | [
"Fn3_SaeA_4th"
] | [
229
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106782",
"PUB00161235"
] | [
"18554329",
"22233444"
] | [
"The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis.",
"Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria."
] | [
2008,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
229
] | 1 | [] | [] | 0 | true | Domain | SaeA, third Fn3-like domain | SaeA, third Fn3-like domain | Fn3_SaeA_3rd | 6 |
IPR058694 | 58,694 | SaeA, fourth Fn3-like domain | Fn3_SaeA_4th | Domain | 326 | false | false | This entry represents the fourth Fn3-like domain found in the ESX-1 scaffolding and assembly protein SaeA and similar proteins from actinomycetes. SaeA is involved in assembly of the ESX-1 secretion system (T7SS), which exports several proteins including EsxA and EsxB. The SaeA protein localises to the bacterial cell p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25835"
] | [
"Fn3_SaeA_5th"
] | [
326
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106782",
"PUB00161235"
] | [
"18554329",
"22233444"
] | [
"The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis.",
"Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria."
] | [
2008,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Methanomethylophilus alvi"
] | [
324,
2
] | 2 | [] | [] | 0 | true | Domain | SaeA, fourth Fn3-like domain | SaeA, fourth Fn3-like domain | Fn3_SaeA_4th | 4 |
IPR058695 | 58,695 | SaeA, N-terminal domain | SaeA_N | Domain | 132 | false | false | This entry represents the N-terminal in SaeA proteins from actinomycetes. This domain shows structural similarity to the HRDC domain ( ). SaeA is involved in assembly of the ESX-1 secretion system (T7SS), which exports several proteins including EsxA and EsxB. The SaeA protein localises to the bacterial cell pole and i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25831"
] | [
"SaeA_1st"
] | [
132
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106782",
"PUB00161235"
] | [
"18554329",
"22233444"
] | [
"The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis.",
"Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria."
] | [
2008,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
132
] | 1 | [] | [] | 0 | true | Domain | SaeA, N-terminal domain | SaeA, N-terminal domain | SaeA_N | 5 |
IPR058696 | 58,696 | SaeA, fifth Fn3-like domain | Fn3_SaeA_5th | Domain | 196 | false | false | This entry represents the fifth Fn3-like domain found in the ESX-1 scaffolding and assembly protein SaeA and similar proteins from actinomycetes. SaeA is involved in assembly of the ESX-1 secretion system (T7SS), which exports several proteins including EsxA and EsxB. The SaeA protein localises to the bacterial cell po... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25836"
] | [
"Fn3_SaeA_6th"
] | [
196
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00106782",
"PUB00161235"
] | [
"18554329",
"22233444"
] | [
"The specialized secretory apparatus ESX-1 is essential for DNA transfer in Mycobacterium smegmatis.",
"Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria."
] | [
2008,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
196
] | 1 | [] | [] | 0 | true | Domain | SaeA, fifth Fn3-like domain | SaeA, fifth Fn3-like domain | Fn3_SaeA_5th | 5 |
IPR058697 | 58,697 | RDRP3-5, N-terminal domain | RDRP3-5_N | Domain | 732 | false | false | This domain is found N-terminal in the plant probable RDR3, RDR4 and RDR5. This domain is not present in RDR1, RDR2 and RDR6. It is predicted to fold into a four α-helical bundle. RDR3, RDR4 and RDR5 are probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs) [ ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26249"
] | [
"4HB_RdRP3_N"
] | [
732
] | 1 | [
"EC"
] | [
"2.7.7.48"
] | [
"EC:2.7.7.48"
] | 1 | [] | 0 | [
"PUB00016353",
"PUB00035781",
"PUB00148892"
] | [
"12553882",
"16691418",
"12650452"
] | [
"Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases.",
"On the origin and functions of RNA-mediated silencing: from protists to man.",
"Analysis of the involvement of an inducible Arabidopsis RNA-... | [
2003,
2006,
2003
] | 3 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
732
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
23,
5,
8
] | 3 | true | Domain | RDRP3-5, N-terminal domain | RDRP3-5, N-terminal domain | RDRP3-5_N | 4 |
IPR058698 | 58,698 | CUB domain, metazoa | CUB_metazoa | Domain | 2,326 | false | false | This is a predicted CUB domain found in a group of uncharacterised proteins mainly found in animals, including from Drosophila simulans. It is often found associated to . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26080"
] | [
"CUB_animal"
] | [
2326
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Ecdysozoa"
] | [
2326
] | 1 | [
"Drosophila melanogaster"
] | [
17
] | 1 | true | Domain | CUB domain, metazoa | CUB domain, metazoa | CUB_metazoa | 3 |
IPR058699 | 58,699 | LARP4/4B, RNA recognition motif | RRM_LARP4/4B | Domain | 4,510 | false | false | This RNA recognition motif (RRM) is found in La-related protein 4 (LARP4) and LARP4B predominantly from animals. LARP4 binds to the poly-A tract of mRNA molecules and plays a role in the regulation of mRNA translation and in the regulation of cell morphology and cytoskeletal organisation [ , ]. This domain is not prese... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26088"
] | [
"RRM_LARP4"
] | [
4510
] | 1 | [] | [] | [] | 0 | [
"6i9b"
] | 1 | [
"PUB00063300",
"PUB00084584",
"PUB00084585",
"PUB00161450",
"PUB00161451",
"PUB00161452"
] | [
"21834987",
"20573744",
"21098120",
"29462618",
"27615744",
"30820564"
] | [
"Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.",
"A stimulatory role for the La-related protein 4B in translation.",
"La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a varia... | [
2011,
2010,
2011,
2018,
2016,
2019
] | 6 | [] | [
"IPR034900",
"IPR034903"
] | 0 | 2 | 0 | [
"Eukaryota"
] | [
4510
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
32,
1,
8,
8,
10
] | 6 | true | Domain | LARP4/4B, RNA recognition motif | LARP4/4B, RNA recognition motif | RRM_LARP4/4B | 7 |
IPR058700 | 58,700 | PIN domain-containing protein, halobacteria | PIN_com-containing_halobact | Family | 77 | false | false | This entry represents a family of uncharacterised proteins from Halobacteria that contains a domain with structural similarity to PIN domains. Proteins in this entry are typically around 200 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26499"
] | [
"PIN_13"
] | [
77
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
77
] | 1 | [] | [] | 0 | true | Family | PIN domain-containing protein, halobacteria | PIN domain-containing protein, halobacteria | PIN_com-containing_halobact | 5 |
IPR058701 | 58,701 | PhiTE_072-like | PhiTE_072-like | Family | 427 | false | false | This entry represents an uncharacterised family of phage and bacterial proteins that includes Phage PhiTE protein PhiTE_072 ( ). The family includes proteins with either one (e.g. ) or two domains (e.g. ). Both classes of proteins share an N-terminal domain that contains a 4 or 5 stranded β-sheet. The fifth strand if p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26211"
] | [
"Phage_phiTE_072"
] | [
427
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"metagenomes"
] | [
405,
17,
5
] | 3 | [] | [] | 0 | true | Family | PhiTE_072-like | PhiTE_072-like | PhiTE_072-like | 5 |
IPR058702 | 58,702 | MafI2-like | MafI2-like | Family | 444 | false | false | This entry includes MafI2 immunity protein from Neisseria meningitidis ( ) and similar bacterial proteins. MafI2 is an immunity protein found in pathogenic Neisseria species, such as Neisseria meningitidis. It is part of the Maf polymorphic toxin system, which consists of toxin (MafB) and immunity (MafI) protein pairs ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26541"
] | [
"MafI2"
] | [
444
] | 1 | [] | [] | [] | 0 | [
"8hhj"
] | 1 | [
"PUB00161329"
] | [
"36849501"
] | [
"Structural basis for the toxic activity of MafB2 from maf genomic island 2 (MGI-2) in N. meningitidis B16B6."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
439,
5
] | 2 | [] | [] | 0 | true | Family | MafI2-like | MafI2-like | MafI2-like | 3 |
IPR058703 | 58,703 | PIN domain-containing protein | PIN-containing | Family | 390 | false | false | This entry represents a group of uncharacterised proteins from halobacteria that contain a PIN domain, which might function as ribonuclease enzymes. Proteins containing this domain are typically around 175 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26425"
] | [
"PIN_halo"
] | [
390
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteriales",
"Planotetraspora kaengkrachanensis"
] | [
389,
1
] | 2 | [] | [] | 0 | true | Family | PIN domain-containing protein | PIN domain-containing protein | PIN-containing | 7 |
IPR058704 | 58,704 | Osteocalcin-like, C-terminal domain | BGLAP-like_C | Domain | 2,004 | false | false | This domain is the GLA domain found at the C-terminal end of bovine Osteocalcin (BGLAP) and similar short sequences mainly found in animals such as Matrix Gla protein. The carboxylated form of BGLAP is one of the main organic components of the bone matrix [ , ]. The uncarboxylated form acts as a hormone secreted by ost... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25890"
] | [
"BGLAP_C"
] | [
2004
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-159763",
"R-DRE-159782",
"R-HSA-159740",
"R-HSA-159763",
"R-HSA-159782",
"R-HSA-8940973",
"R-MMU-159740",
"R-MMU-159763",
"R-MMU-159782",
"R-RNO-159740",
"R-RNO-159763",
"R-RNO-159782",
"R-XTR-159740",
"R-XTR-159763",
"R-XTR-159782"
] | [
"REACTOME:R-DRE-159763",
"REACTOME:R-DRE-159782",
"REACTOME:R-HSA-159740",
"REACTOME:R-HSA-159763",
"REACTOME:R-HSA-159782",
"REACTOME:R-HSA-8940973",
"REACTOME:R-MMU-159740",
"REACTOME:R-MMU-159763",
"REACTOME:R-MMU-159782",
"REACTOME:R-RNO-159740",
"REACTOME:R-RNO-159763",
"REACTOME:R-RNO-15... | 15 | [
"1q3m",
"1q8h",
"1vzm",
"4mzz",
"8i74",
"8i75",
"8i76",
"9bur",
"9bux",
"9l23",
"9mqb",
"9mqc",
"9mqe"
] | 13 | [
"PUB00030105",
"PUB00030165",
"PUB00032135",
"PUB00044565",
"PUB00044566",
"PUB00044567",
"PUB00161143",
"PUB00161144",
"PUB00161145",
"PUB00161146",
"PUB00161147",
"PUB00161148",
"PUB00161149",
"PUB00161640",
"PUB00161641",
"PUB00161642",
"PUB00161643"
] | [
"12820886",
"14586470",
"15667217",
"18374189",
"11818531",
"18374194",
"6792200",
"6332627",
"3019668",
"6967872",
"8684484",
"24138653",
"36976525",
"20655470",
"20655471",
"21333348",
"24074871"
] | [
"The three-dimensional structure of bovine calcium ion-bound osteocalcin using 1H NMR spectroscopy.",
"Bone recognition mechanism of porcine osteocalcin from crystal structure.",
"Structural evidence of a fourth Gla residue in fish osteocalcin: biological implications.",
"The vitamin K cycle.",
"gamma -Glut... | [
2003,
2003,
2005,
2008,
2002,
2008,
1981,
1984,
1986,
1980,
1996,
2013,
2023,
2010,
2010,
2011,
2013
] | 17 | [
"IPR000294"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
2004
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
7,
8
] | 4 | true | Domain | Osteocalcin-like, C-terminal domain | Osteocalcin-like, C-terminal domain | BGLAP-like_C | 9 |
IPR058705 | 58,705 | Alpha-helical endospore appendage domain-containing protein | A_ENA | Family | 1,447 | false | false | This entry represents a group of uncharacterised proteins from firmicutes that contain the α-helical endospore appendage (A-ENA) domain. A-ENA proteins form 8 nm diameter protein nanofibers with a double helical symmetry that function as extrasporal matrix components in bacterial spore biofilms. Its structure consists ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26595"
] | [
"A_ENA"
] | [
1447
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Siphoviridae sp. ct8HH20",
"bioreactor metagenome"
] | [
1445,
1,
1
] | 3 | [] | [] | 0 | true | Family | Alpha-helical endospore appendage domain-containing protein | Alpha-helical endospore appendage domain-containing protein | A_ENA | 3 |
IPR058706 | 58,706 | AHC1-like, C2H2 zinc-finger domain | Znf-C2H2_AHC1-like | Domain | 1,342 | false | false | This entry describes the zinc finger domain in AHC1 proteins found in fungi. AHC1 proteins are involved in chromatin interaction and potential signal transduction processes. They are part of ADA histone acetyltransferase complex involved in repair of replication-born double-strand DNA breaks [ , ]. AHC1 lacks orthologu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25909"
] | [
"zf-C2H2_AHC1"
] | [
1342
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161117",
"PUB00161118",
"PUB00161119"
] | [
"25128619",
"30715476",
"10490601"
] | [
"Chromatin regulation of DNA damage repair and genome integrity in the central nervous system.",
"Characterization of a metazoan ADA acetyltransferase complex.",
"The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae."
] | [
2014,
2019,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1342
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | AHC1-like, C2H2 zinc-finger domain | AHC1-like, C2H2 zinc-finger domain | Znf-C2H2_AHC1-like | 6 |
IPR058707 | 58,707 | AHC1, N-terminal | AHC1_N | Domain | 68 | false | false | This entry describes the N-terminal domain in AHC1 proteins found in Saccharomycetes. AHC1 proteins are involved in chromatin interaction and potential signal transduction processes. They are part of ADA histone acetyltransferase complex involved in repair of replication-born double-strand DNA breaks [ , ]. AHC1 has no... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25910"
] | [
"AHC1_N"
] | [
68
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161117",
"PUB00161118",
"PUB00161119"
] | [
"25128619",
"30715476",
"10490601"
] | [
"Chromatin regulation of DNA damage repair and genome integrity in the central nervous system.",
"Characterization of a metazoan ADA acetyltransferase complex.",
"The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae."
] | [
2014,
2019,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Saccharomycetes"
] | [
68
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | AHC1, N-terminal | AHC1, N-terminal | AHC1_N | 9 |
IPR058708 | 58,708 | AHC1, C-terminal | AHC1_C | Domain | 47 | false | false | This entry describes the C-terminal domain in AHC1 proteins found in Saccharomycetes. AHC1 proteins are involved in chromatin interaction and potential signal transduction processes. They are part of ADA histone acetyltransferase complex involved in repair of replication-born double-strand DNA breaks [ , ]. AHC1 has no... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25911"
] | [
"AHC1_C"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161117",
"PUB00161118",
"PUB00161119"
] | [
"25128619",
"30715476",
"10490601"
] | [
"Chromatin regulation of DNA damage repair and genome integrity in the central nervous system.",
"Characterization of a metazoan ADA acetyltransferase complex.",
"The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae."
] | [
2014,
2019,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Saccharomycetaceae"
] | [
47
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | AHC1, C-terminal | AHC1, C-terminal | AHC1_C | 6 |
IPR058709 | 58,709 | RND related, barrel-sandwich hybrid domain | BSH_RND-rel | Domain | 904 | false | false | This domain is found in proteins from firmicutes that are related to RND (resistance-nodulation-division) efflux pump components. It is interrupted by an α-helical insertion ( ) which split the domain into two sequentially separated parts. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26018"
] | [
"BSH_RND_rel"
] | [
904
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
892,
12
] | 2 | [] | [] | 0 | true | Domain | RND related, barrel-sandwich hybrid domain | RND related, barrel-sandwich hybrid domain | BSH_RND-rel | 7 |
IPR058710 | 58,710 | PPi-type phosphoenolpyruvate carboxykinase lobe 2 domain | PEPCK_lobe_2 | Domain | 529 | false | false | This entry represents the second lobe domain [ ] of PPi-type phosphoenolpyruvate carboxykinase (PEPCK) enzymes from lower eukaryotes and bacteria. This domain is not catalytic. These enzymes play a crucial role in regulating the carbon flow of central metabolism. They are inorganic pyrophosphate (PPi)-dependent and are... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26300"
] | [
"PEPCK_PPi_lobe_2"
] | [
529
] | 1 | [
"EC"
] | [
"4.1.1.38"
] | [
"EC:4.1.1.38"
] | 1 | [
"6k31",
"8e1u"
] | 2 | [
"PUB00161401",
"PUB00161402",
"PUB00161403"
] | [
"31662435",
"26269598",
"37226637"
] | [
"Structural comparisons of phosphoenolpyruvate carboxykinases reveal the evolutionary trajectories of these phosphodiester energy conversion enzymes.",
"Discovery of PPi-type Phosphoenolpyruvate Carboxykinase Genes in Eukaryotes and Bacteria.",
"Biochemical, structural, and kinetic characterization of PP<sub... | [
2019,
2015,
2023
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
450,
66,
13
] | 3 | [] | [] | 0 | true | Domain | PPi-type phosphoenolpyruvate carboxykinase lobe 2 domain | PPi-type phosphoenolpyruvate carboxykinase lobe 2 domain | PEPCK_lobe_2 | 7 |
IPR058711 | 58,711 | SCO6045-like, C-terminal domain | SCO6045-like_C | Domain | 1,542 | false | false | This domain is found at the C-terminal end of a group of uncharacterised bacterial proteins, including SCO6045 from Streptomyces coelicolor. This domain, which is predicted to adopt an all-α structure, is found associated with in some members of this group. This domain is also found covering the whole length of the pro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26136"
] | [
"SCO6045_C"
] | [
1542
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161457"
] | [
"31863750"
] | [
"Structural Insights into the Specific Recognition of 5-methylcytosine and 5-hydroxymethylcytosine by TAL Effectors."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
1542
] | 1 | [] | [] | 0 | true | Domain | SCO6045-like, C-terminal domain | SCO6045-like, C-terminal domain | SCO6045-like_C | 7 |
IPR058712 | 58,712 | ScoMcrA-like, SRA domain | SRA_ScoMcrA | Domain | 1,142 | false | false | This entry represents the SRA domain found in the endonuclease ScoMcrA and related type IV restriction enzymes. This domain has a detectable similarity to known PUA domains. The ScoMcrA SRA domain mediates dimerisation and does not engage in interactions with the phosphorothioated DNA [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26348"
] | [
"SRA_ScoMcrA"
] | [
1142
] | 1 | [] | [] | [] | 0 | [
"5zmm",
"5zmn"
] | 2 | [
"PUB00154747"
] | [
"30409991"
] | [
"Structural basis for the recognition of sulfur in phosphorothioated DNA."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Viruses",
"metagenomes"
] | [
131,
994,
3,
14
] | 4 | [] | [] | 0 | true | Domain | ScoMcrA-like, SRA domain | ScoMcrA-like, SRA domain | SRA_ScoMcrA | 6 |
IPR058713 | 58,713 | N,N-dimethylformamidase, alpha subunit domain | DMF_alpha_dom | Domain | 405 | false | false | This entry represents a domain that covers the whole length of the alpha subunit (DmfA1) of N,N-dimethylformamidase, an enzyme that catalyses the hydrolysis of N,N-dimethylformamide to dimethylamine and formate [ ]. The enzyme functions as a heterotetramer composed of two alpha (DmfA1) and two beta (DmfA2) subunits. It... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26354"
] | [
"DMF_alpha"
] | [
405
] | 1 | [] | [] | [] | 0 | [
"6lvb",
"6lvc",
"6lvd",
"6lve",
"6lvv",
"7w8j"
] | 6 | [
"PUB00161644"
] | [
"10664842"
] | [
"Cloning and expression of the N,N-dimethylformamidase gene from Alcaligenes sp. strain KUFA-1."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"ecological metagenomes"
] | [
365,
3,
37
] | 3 | [] | [] | 0 | true | Domain | N,N-dimethylformamidase, alpha subunit domain | N,N-dimethylformamidase, alpha subunit domain | DMF_alpha_dom | 6 |
IPR058714 | 58,714 | Lipoprotein LpqS | LpqS | Family | 523 | false | false | This family includes Lipoprotein LpqS from Mycobacterium tuberculosis and similar proteins from actinomycetes. LpqS is implicated in the replication and survival of Mycobacterium tuberculosis within host cells [ ]. This suggests a potential role in the pathogen's ability to persist and proliferate during infection, whi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26327"
] | [
"LpqS"
] | [
523
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161324"
] | [
"23562345"
] | [
"The lpqS knockout mutant of Mycobacterium tuberculosis is attenuated in macrophages."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"freshwater metagenome"
] | [
521,
2
] | 2 | [] | [] | 0 | true | Family | Lipoprotein LpqS | Lipoprotein LpqS | LpqS | 4 |
IPR058715 | 58,715 | PD-(D/E)XK nuclease related | PDDEXK_nuclease-rel | Family | 395 | false | false | This entry represents a family of putative nucleases found in proteins from halobacteria and some viruses. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25941"
] | [
"PDDEXK_16"
] | [
395
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Stenosarchaea group",
"Streptomyces",
"Viruses",
"marine sediment metagenome"
] | [
375,
2,
16,
2
] | 4 | [] | [] | 0 | true | Family | PD-(D/E)XK nuclease related | PD-(D/E)XK nuclease related | PDDEXK_nuclease-rel | 4 |
IPR058716 | 58,716 | WNWW domain-containing protein | WNWW_dom-containing | Family | 326 | false | false | This entry represents a family of uncharacterised proteins from Halobacteria. Its exact function remains unknown. It contains a highly conserved WNWW motif close to the C terminus after which the domain is named. Tryptophan is usually a relatively uncommon amino acid so this motif is unusual. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26484"
] | [
"WNWW"
] | [
326
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
326
] | 1 | [] | [] | 0 | true | Family | WNWW domain-containing protein | WNWW domain-containing protein | WNWW_dom-containing | 1 |
IPR058719 | 58,719 | Cell growth-regulating nucleolar protein-like, winged helix domain | WHD_LYAR | Domain | 2,595 | false | false | This entry represents the C-terminal winged helix domain (WHD) found in the LYAR family of proteins, including mammal Cell growth-regulating nucleolar protein (LYAR), and similar sequences mainly found in animals and plants. LYAR plays a crucial role in ribosome biogenesis and transcription regulation. Members of this ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25879"
] | [
"WHD_LYAR"
] | [
2595
] | 1 | [] | [] | [] | 0 | [
"6zmi",
"6zmo",
"6zvh",
"7xnx"
] | 4 | [
"PUB00090407",
"PUB00090408",
"PUB00090409",
"PUB00161527",
"PUB00161528",
"PUB00161529",
"PUB00161530"
] | [
"24495227",
"25092918",
"28686580",
"31413131",
"19489080",
"25735755",
"29375609"
] | [
"Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA.",
"Human fetal globin gene expression is regulated by LYAR.",
"Upregulation of LYAR induces neuroblastoma cell proliferation and survival.",
"LYAR Suppresses Beta Interferon Induction by Targeting Phospho... | [
2014,
2014,
2017,
2019,
2009,
2015,
2017
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2595
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
1,
2,
2,
1,
4,
4,
11
] | 8 | true | Domain | Cell growth-regulating nucleolar protein-like, winged helix domain | Cell growth-regulating nucleolar protein-like, winged helix domain | WHD_LYAR | 8 |
IPR058720 | 58,720 | CHMP7, N-terminal winged helix domain | WHD_CHMP7_1st | Domain | 2,992 | false | false | This entry represents the N-terminal of two tandem winged helix domains found in the Charged Multivesicular Body Protein 7 family. The second is found in . The Charged Multivesicular Body Protein 7 family is involved in the endosomal sorting pathway and plays a crucial role during cell division. This family is characte... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25880"
] | [
"WHD_CHMP7_1st"
] | [
2992
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DDI-1632852",
"R-DDI-917729",
"R-DDI-9668328",
"R-DRE-1632852",
"R-DRE-917729",
"R-DRE-9668328",
"R-GGA-1632852",
"R-GGA-5620971",
"R-GGA-917729",
"R-GGA-9668328",
"R-HSA-162588",
"R-HSA-1632852",
"R-HSA-5620971",
"R-HSA-917729",
"R-HSA-9610379",
"R-HSA-9615710",
"R-HSA-9668328",
... | [
"REACTOME:R-DDI-1632852",
"REACTOME:R-DDI-917729",
"REACTOME:R-DDI-9668328",
"REACTOME:R-DRE-1632852",
"REACTOME:R-DRE-917729",
"REACTOME:R-DRE-9668328",
"REACTOME:R-GGA-1632852",
"REACTOME:R-GGA-5620971",
"REACTOME:R-GGA-917729",
"REACTOME:R-GGA-9668328",
"REACTOME:R-HSA-162588",
"REACTOME:R-... | 32 | [] | 0 | [
"PUB00160205",
"PUB00160206",
"PUB00161521"
] | [
"26040712",
"28242692",
"16856878"
] | [
"Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.",
"LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.",
"CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway."
] | [
2015,
2017,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2992
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
1,
4,
1,
2,
3,
3,
1,
1,
6
] | 12 | true | Domain | CHMP7, N-terminal winged helix domain | CHMP7, N-terminal winged helix domain | WHD_CHMP7_1st | 8 |
IPR058722 | 58,722 | RNA-editing substrate-binding complex 5 protein | RESC5 | Domain | 107 | false | false | This domain is found in the RNA-editing substrate-binding complex 5 protein (RESC5) from Trypanosoma brucei, a component of RESC which, together with RECC, forms the editosome that orchestrates guide RNA (gRNA)-programmed editing to recode cryptic mitochondrial transcripts into messenger RNAs [ ]. RESC stabilises gRNAs... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF26170",
"cd23678"
] | [
"RESC5",
"RESC5"
] | [
107,
82
] | 2 | [] | [] | [] | 0 | [
"8dpk",
"8fn4",
"8fn6",
"8fnc",
"8fnf",
"8fni",
"8fnk"
] | 7 | [
"PUB00157634",
"PUB00157638",
"PUB00157639",
"PUB00158232",
"PUB00158233",
"PUB00158234",
"PUB00158235",
"PUB00160174"
] | [
"32191849",
"30213880",
"33677542",
"26447184",
"25225332",
"24250748",
"20654741",
"37410820"
] | [
"Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.",
"Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.",
"Trypanosome RNAEditing Substrate Binding Complex integrity and function depends on the upstream action of RESC10.",
"Integrity of the core mit... | [
2020,
2018,
2021,
2015,
2014,
2013,
2010,
2023
] | 8 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Eukaryota",
"freshwater metagenome"
] | [
9,
97,
1
] | 3 | [] | [] | 0 | true | Domain | RNA-editing substrate-binding complex 5 protein | RNA-editing substrate-binding complex 5 protein | RESC5 | 1 |
IPR058723 | 58,723 | Weld-like protein, Lid domain | Lid_Weld | Domain | 60 | false | false | This entry represents the lid domain of the weld protein from bacteriophage phi812 and associated proteins. Phi812 is a bacteriophage that infects Staphylococcus aureus, including many methicillin-resistant strains (MRSA). The weld protein of phi812 can be divided into N-terminal lid and C-terminal clip ( ) domains, wh... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26537"
] | [
"Phi812_weld_lid"
] | [
60
] | 1 | [] | [] | [] | 0 | [
"9euf",
"9eug",
"9euh"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
60
] | 1 | [] | [] | 0 | true | Domain | Weld-like protein, Lid domain | Weld-like protein, Lid domain | Lid_Weld | 2 |
IPR058724 | 58,724 | YhzF | YhzF | Family | 281 | false | false | This entry represents a family of small integral membrane proteins found in bacilli. The protein is composed of two transmembrane α-helices. There is some weak evidence from structure predictions that these proteins might form a homodimeric complex. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26302"
] | [
"YhzF"
] | [
281
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillales"
] | [
281
] | 1 | [] | [] | 0 | true | Family | YhzF | YhzF | YhzF | 4 |
IPR058725 | 58,725 | YczF | YczF | Family | 436 | false | false | This entry contains the uncharacterised B. subtilis protein YczF ( ) and its homologues. This protein is about 80 amino acids in length and contains two transmembrane helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26310"
] | [
"YczF"
] | [
436
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillales"
] | [
436
] | 1 | [] | [] | 0 | true | Family | YczF | YczF | YczF | 2 |
IPR058726 | 58,726 | Roller-3, N-terminal domain | Roller3_N | Domain | 106 | false | false | This entry represents the N-terminal α-helical domain from Roller-3 proteins [ , ]. According to ECOD this domain shows structural similarity to . Roller-3 is involved in the development and locomotion of organisms. It plays a crucial role in larval development and is thought to contribute to the establishment of poste... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26432"
] | [
"Roller3_N"
] | [
106
] | 1 | [
"REACTOME"
] | [
"R-CEL-8863795"
] | [
"REACTOME:R-CEL-8863795"
] | 1 | [] | 0 | [
"PUB00160112",
"PUB00161449"
] | [
"8138151",
"1752418"
] | [
"The generation and genetic analysis of suppressors of lethal mutations in the Caenorhabditis elegans rol-3(V) gene.",
"Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans."
] | [
1994,
1991
] | 2 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
106
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Roller-3, N-terminal domain | Roller-3, N-terminal domain | Roller3_N | 1 |
IPR058727 | 58,727 | Vwde, helical domain | Helical_Vwde | Domain | 2,474 | false | false | This domain is found in mouse von Willebrand factor D and EGF domain-containing protein (Vwde) and similar animal sequences. Vwde may play a role in initial ameloblast differentiation and is involved in the maturation of enamel mineralisation [ ]. This domain is predicted to have an all-α helical configuration and is o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26129"
] | [
"Vwde"
] | [
2474
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161520"
] | [
"34957547"
] | [
"von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"viral metagenome"
] | [
2473,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
2,
3
] | 4 | true | Domain | Vwde, helical domain | Vwde, helical domain | Helical_Vwde | 2 |
IPR058728 | 58,728 | RND related, alpha-helical hairpin domain | HH_RND-rel | Domain | 204 | false | false | This α-helical insertion domain is found in proteins from firmicutes that are related to RND (resistance-nodulation-division) efflux pump components. It interrupts , which is split into two sequentially separated parts. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26012"
] | [
"HH_RND_rel"
] | [
204
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
203,
1
] | 2 | [] | [] | 0 | true | Domain | RND related, alpha-helical hairpin domain | RND related, alpha-helical hairpin domain | HH_RND-rel | 2 |
IPR058729 | 58,729 | RND related, beta-barrel domain | Beta-barrel_RND-rel | Domain | 453 | false | false | This domain is found in proteins from firmicutes that are related to RND (resistance-nodulation-division) efflux pump components. The domain represented in this entry folds into a six-stranded closed β-barrel with a greek-key topology which has a structural similarity to the C-terminal domain of alanine racemase. This ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26011"
] | [
"Beta-barrel_RND_rel"
] | [
453
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota",
"metagenomes"
] | [
447,
6
] | 2 | [] | [] | 0 | true | Domain | RND related, beta-barrel domain | RND related, beta-barrel domain | Beta-barrel_RND-rel | 8 |
IPR058730 | 58,730 | ZFPL1-like, U-box domain | U-box_ZFPL1-like | Domain | 2,036 | false | false | This domain is found immediately C-terminal to in ZFPL1 mostly from metazoa and uncharacterised plant proteins. This domain is predicted to adopt a U-box configuration. Zinc finger protein-like 1 (ZFPL1) is required for cis-Golgi integrity and efficient ER to Golgi transport, possibly via its interaction with GOLGA2/GM... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25998"
] | [
"U-box_ZFPL1"
] | [
2036
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088814"
] | [
"18323775"
] | [
"ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2036
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
1,
6,
1,
4,
6,
3,
2,
5
] | 9 | true | Domain | ZFPL1-like, U-box domain | ZFPL1-like, U-box domain | U-box_ZFPL1-like | 4 |
IPR058731 | 58,731 | ZFPL1-like, B-box zinc-binding domain | Znf-B_box_ZFPL1-like | Domain | 1,961 | false | false | This B-box zinc-binding domain is found at the N-terminal end in ZFPL1 mostly found in metazoa and uncharacterised plant proteins. Zinc finger protein-like 1 (ZFPL1) is required for cis-Golgi integrity and efficient ER to Golgi transport, possibly via its interaction with GOLGA2/GM130 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25993"
] | [
"zf-B_box_ZFPL1"
] | [
1961
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088814"
] | [
"18323775"
] | [
"ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
1960,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
1,
6,
1,
8,
7,
3,
2,
5
] | 9 | true | Domain | ZFPL1-like, B-box zinc-binding domain | ZFPL1-like, B-box zinc-binding domain | Znf-B_box_ZFPL1-like | 8 |
IPR058732 | 58,732 | RUN domain-containing protein 1, middle domain | RUNDC1_M | Domain | 1,612 | false | false | This domain is found in human RUNDC1 and similar proteins mainly found in animals. This domain is predicted to adopt an all-α configuration. RUN domain-containing protein 1 (RUNDC1) is thought to play a role as p53/TP53 inhibitor and as such may have oncogenic activity [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26030"
] | [
"RUNDC1"
] | [
1612
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00018296",
"PUB00102654"
] | [
"11166556",
"16929179"
] | [
"RUN domains: a new family of domains involved in Ras-like GTPase signaling.",
"A high-throughput loss-of-function screening identifies novel p53 regulators."
] | [
2001,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1612
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
2,
1,
4
] | 6 | true | Domain | RUN domain-containing protein 1, middle domain | RUN domain-containing protein 1, middle domain | RUNDC1_M | 1 |
IPR058737 | 58,737 | REH2, DRSM domain | DSRM_REH2 | Domain | 236 | false | false | This entry represents a DSRM domain found in RNA editing associated helicase 2 (REH2) and similar eukaryotic proteins. The RNA editing-associated helicase 2 family is involved in mitochondrial mRNA editing, a crucial process that includes the addition and deletion of uridine nucleotides in pre-mRNA. These proteins func... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26536"
] | [
"DSRM_REH2"
] | [
236
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00158276",
"PUB00161218",
"PUB00161219",
"PUB00161220"
] | [
"25928631",
"19850921",
"26769962",
"31034523"
] | [
"Native Variants of the MRB1 Complex Exhibit Specialized Functions in Kinetoplastid RNA Editing.",
"REH2 RNA helicase in kinetoplastid mitochondria: ribonucleoprotein complexes and essential motifs for unwinding and guide RNA (gRNA) binding.",
"REH2C Helicase and GRBC Subcomplexes May Base Pair through mRNA and... | [
2015,
2010,
2016,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
236
] | 1 | [
"Homo sapiens",
"Rattus norvegicus"
] | [
2,
1
] | 2 | true | Domain | REH2, DRSM domain | REH2, DRSM domain | DSRM_REH2 | 4 |
IPR058738 | 58,738 | Apoptosis-resistant E3 ubiquitin protein ligase 1, PH-like domain | PH-like_AREL1 | Domain | 1,853 | false | false | This entry describes the PH-like domain in Apoptosis-resistant E3 ubiquitin protein ligase 1 (AREL1) found in animals. PH domains function as membrane-targeting modules that bind phosphoinositide lipids and/or proteins to localise signalling molecules to specific cellular membranes [ , ]. Apoptosis-resistant E3 ubiquit... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25916"
] | [
"AREL1_PH-like"
] | [
1853
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 2 | [] | 0 | [
"PUB00080402",
"PUB00161123",
"PUB00161124",
"PUB00161125",
"PUB00161126"
] | [
"17233582",
"31578312",
"23479728",
"25752577",
"9891074"
] | [
"Pleckstrin homology (PH) domains and phosphoinositides.",
"KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.",
"Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.",
"Assembly and specific rec... | [
2007,
2019,
2013,
2015,
1999
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1853
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
6,
4,
2
] | 5 | true | Domain | Apoptosis-resistant E3 ubiquitin protein ligase 1, PH-like domain | Apoptosis-resistant E3 ubiquitin protein ligase 1, PH-like domain | PH-like_AREL1 | 2 |
IPR058739 | 58,739 | NicX | NicX | Family | 3,411 | false | false | This entry represents NicX and related prokaryotic proteins. 2,5-dihydroxypyridine 5,6-dioxygenase (NicX) catalyses the dioxygenolytic ring cleavage of 2,5-dihydroxypyridine between carbons 5 and 6 generating N-formylmaleamate. It is a component of the Nic cluster, which is responsible for the aerobic nicotinate degrad... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26233"
] | [
"NicX"
] | [
3411
] | 1 | [] | [] | [] | 0 | [
"7cn3",
"7cnt",
"7cup"
] | 3 | [
"PUB00068857"
] | [
"18678916"
] | [
"Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
522,
2724,
21,
144
] | 4 | [] | [] | 0 | true | Family | NicX | NicX | NicX | 9 |
IPR058740 | 58,740 | MurL, N-terminal domain | MurL_N | Domain | 1,297 | false | false | This entry represents the N-terminal domain of MurL (UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase. This N-terminal domain likely participates in ATP binding and substrate recognition. The paper describing MurL indicates that the enzyme has no putative conserved domains or cofactor binding domains curren... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26299"
] | [
"MurL_N"
] | [
1297
] | 1 | [
"EC",
"METACYC"
] | [
"5.1.1.23",
"PWY-7953"
] | [
"EC:5.1.1.23",
"METACYC:PWY-7953"
] | 2 | [] | 0 | [
"PUB00094462"
] | [
"28294606"
] | [
"A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanolliviera hydrocarbonicum",
"Eukaryota",
"metagenomes"
] | [
1174,
1,
86,
36
] | 4 | [] | [] | 0 | true | Domain | MurL, N-terminal domain | MurL, N-terminal domain | MurL_N | 4 |
IPR058741 | 58,741 | MurL, C-terminal domain | MurL_C | Domain | 1,276 | false | false | This entry represents the C-terminal domain of MurL, a novel glycopeptidyl- glutamate epimerase involved in bacterial cell wall formation. MurL is an ATP-dependent enzyme that catalyses the epimerisation of the terminal L-glutamate residue in UDP-MurNAc-L-Ala-L-Glu to D-glutamate, functioning in conjunction with MurD2-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26298"
] | [
"MurL_epimerase_C"
] | [
1276
] | 1 | [
"EC",
"METACYC"
] | [
"5.1.1.23",
"PWY-7953"
] | [
"EC:5.1.1.23",
"METACYC:PWY-7953"
] | 2 | [] | 0 | [
"PUB00094462"
] | [
"28294606"
] | [
"A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanolliviera hydrocarbonicum",
"Eukaryota",
"ecological metagenomes"
] | [
1169,
1,
74,
32
] | 4 | [] | [] | 0 | true | Domain | MurL, C-terminal domain | MurL, C-terminal domain | MurL_C | 7 |
IPR058742 | 58,742 | Protein of unknown function DUF7989 | DUF7989 | Family | 276 | false | false | This entry describes a group of uncharacterised proteins from Halobacteriales, which are small in size (~80 aa) and are predicted to be largely disordered. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25951"
] | [
"DUF7989"
] | [
276
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea"
] | [
276
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF7989 | Protein of unknown function DUF7989 | DUF7989 | 7 |
IPR058743 | 58,743 | Salmonella anti-inflammatory response activator | SarA | Family | 81 | false | false | This protein family comprises effector molecules secreted via specialised type III secretion systems that modulate host immune responses in a sophisticated manner [ ]. They harbour conserved sequence motifs, notably a YxxQ element whose activity is enhanced by an invariant isoleucine at the pY+1 position, making them e... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26316"
] | [
"SarA_SteE"
] | [
81
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161453"
] | [
"40188438"
] | [
"A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory gene expression."
] | [
2025
] | 1 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
81
] | 1 | [] | [] | 0 | true | Family | Salmonella anti-inflammatory response activator | Salmonella anti-inflammatory response activator | SarA | 1 |
IPR058744 | 58,744 | BstA-like, C-terminal domain | BstA-like_C | Domain | 378 | false | false | This entry represents the C-terminal domain of the BstA protein, an abortive infection protein found in prophages of diverse Gram-negative bacteria . BstA mediates population-level defence against exogenous phage infection by localising to sites of phage DNA replication and inhibiting phage propagation. The C-terminal ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26567"
] | [
"BstA_C"
] | [
378
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161161"
] | [
"34597593"
] | [
"Prophages encode phage-defense systems with cognate self-immunity."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Knufia peltigerae",
"Viruses",
"metagenomes"
] | [
368,
1,
5,
4
] | 4 | [] | [] | 0 | true | Domain | BstA-like, C-terminal domain | BstA-like, C-terminal domain | BstA-like_C | 2 |
IPR058745 | 58,745 | Topors, PWI-like domain | PWI_Topors | Domain | 1,491 | false | false | This domain is found in the human E3 ubiquitin-protein ligase Topors and related animal proteins. The domain represented by this entry has a detectable sequence similarity to known PWI domains, and it is predicted to adopt a similar structure. Topors, also known as topoisomerase I-binding RING finger protein, tumour su... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26084"
] | [
"PWI_Topors"
] | [
1491
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-HSA-3899300",
"R-HSA-4085377",
"R-HSA-4755510",
"R-MMU-3899300",
"R-MMU-4085377",
"R-MMU-4755510"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-HSA-3899300",
"REACTOME:R-HSA-4085377",
"REACTOME:R-HSA-4755510",
"REACTOME:R-MMU-3899300",
"REACTOME:R-MMU-4085377",
"REACTOME:R-MMU-4755510"
] | 8 | [] | 0 | [
"PUB00135444",
"PUB00135447",
"PUB00135452",
"PUB00135454",
"PUB00135457",
"PUB00161430",
"PUB00161431"
] | [
"18077445",
"16122737",
"19473992",
"17803295",
"15247280",
"16209949",
"20188669"
] | [
"Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.",
"Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo.",
"Plk1-mediated phosphorylation of Topors regulates p53 stability.",
"TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.",
"Topors functions as ... | [
2008,
2005,
2009,
2007,
2004,
2005,
2010
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1491
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2,
4,
4
] | 5 | true | Domain | Topors, PWI-like domain | Topors, PWI-like domain | PWI_Topors | 5 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.