LiteFold/InterPro · Datasets at Hugging Face

IPR006255

6,255

Dihydrolipoamide succinyltransferase

SucB

Family

19,022

false

These sequences describe the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. Members include the mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly ...

[ "GO:0004149", "GO:0006099", "GO:0045252" ]

[ "dihydrolipoyllysine-residue succinyltransferase activity", "tricarboxylic acid cycle", "oxoglutarate dehydrogenase complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01347" ]

[ "sucB" ]

[ 19022 ]

1

[ "EC", "GP", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REAC...

[ "2.3.1.61", "GenProp0630", "GenProp1348", "GenProp1693", "PWY-5084", "R-DDI-6783984", "R-DDI-9853506", "R-DDI-9857492", "R-DDI-9858328", "R-HSA-6783984", "R-HSA-9853506", "R-HSA-9857492", "R-HSA-9858328", "R-MMU-6783984", "R-MMU-9853506", "R-MMU-9857492", "R-MMU-9858328", "R-RNO-67...

[ "EC:2.3.1.61", "GP:GenProp0630", "GP:GenProp1348", "GP:GenProp1693", "METACYC:PWY-5084", "REACTOME:R-DDI-6783984", "REACTOME:R-DDI-9853506", "REACTOME:R-DDI-9857492", "REACTOME:R-DDI-9858328", "REACTOME:R-HSA-6783984", "REACTOME:R-HSA-9853506", "REACTOME:R-HSA-9857492", "REACTOME:R-HSA-98583...

27

[ "1c4t", "1e2o", "1scz", "6h05", "6pbr", "7q5q", "7uol", "8oiu", "8x02", "8xll", "9dz8", "9mu6", "9njt" ]

13

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 13568, 5357, 97 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 10, 1, 1, 1, 1, 3, 1, 1, 6, 8, 1, 1, 16 ]

13

true

Family

Dihydrolipoamide succinyltransferase

SucB

1

IPR006256

6,256

Dihydrolipoamide acetyltransferase pyruvate dehydrogenase complex

AcTrfase_Pyrv_DH_cplx

Family

6,506

false

This group of sequences are a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and percent identity (UPGMA) trees. Members contain two or three copies of the lipoyl-binding domain. Escherichia coli AceF is included in this set while mitochondrial and so...

[ "GO:0004742", "GO:0045254" ]

[ "dihydrolipoyllysine-residue acetyltransferase activity", "pyruvate dehydrogenase complex" ]

[ "molecular_function", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01348" ]

[ "PDHac_trf_long" ]

[ 6506 ]

1

[ "EC", "GP", "GP" ]

[ "2.3.1.12", "GenProp1536", "GenProp1710" ]

[ "EC:2.3.1.12", "GP:GenProp1536", "GP:GenProp1710" ]

3

[ "7b9k" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6455, 3, 48 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Dihydrolipoamide acetyltransferase pyruvate dehydrogenase complex

AcTrfase_Pyrv_DH_cplx

7

IPR006257

6,257

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

LAT1

Family

8,871

false

The pyruvate dehydrogenase complex catalyses the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) [ ]. This entry represent the dihydrolipoamide acetyltra...

[ "GO:0004742", "GO:0006090", "GO:0045254" ]

[ "dihydrolipoyllysine-residue acetyltransferase activity", "pyruvate metabolic process", "pyruvate dehydrogenase complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01349" ]

[ "PDHac_trf_mito" ]

[ 8871 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "2.3.1.12", "GenProp1536", "R-BTA-204174", "R-BTA-5362517", "R-BTA-9857492", "R-BTA-9861559", "R-CEL-204174", "R-CEL-5362517", "R-CEL-9857492", "R-CEL-9861559", "R-DDI-9857492", "R-DDI-9861559", "R-HSA-204174", "R-HSA-5362517", "R-HSA-9857492", "R-HSA-9861559", "R-MMU-204174", "R-M...

[ "EC:2.3.1.12", "GP:GenProp1536", "REACTOME:R-BTA-204174", "REACTOME:R-BTA-5362517", "REACTOME:R-BTA-9857492", "REACTOME:R-BTA-9861559", "REACTOME:R-CEL-204174", "REACTOME:R-CEL-5362517", "REACTOME:R-CEL-9857492", "REACTOME:R-CEL-9861559", "REACTOME:R-DDI-9857492", "REACTOME:R-DDI-9861559", "...

30

[ "6ct0", "6h55", "6zlm", "7bgj", "7ott", "7q5r", "7uom", "8ohs", "8piu", "8x03", "9j1w" ]

11

[ "PUB00000614" ]

[ "1825611" ]

[ "Sequence similarities within the family of dihydrolipoamide acyltransferases and discovery of a previously unidentified fungal enzyme." ]

[ 1991 ]

1

[ "IPR045257" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 4392, 4459, 20 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 2, 3, 13, 1, 1, 9, 2, 1, 1, 11 ]

12

true

Family

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

LAT1

7

IPR006258

6,258

Dihydrolipoamide dehydrogenase

Lipoamide_DH

Family

44,393

false

These sequences represent dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members kno...

[ "GO:0004148", "GO:0050660" ]

[ "dihydrolipoyl dehydrogenase (NADH) activity", "flavin adenine dinucleotide binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR01350" ]

[ "lipoamide_DH" ]

[ 44393 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...

[ "1.8.1.4", "GenProp0178", "GenProp0630", "GenProp1223", "GenProp1275", "GenProp1348", "GenProp1356", "GenProp1408", "GenProp1439", "GenProp1533", "GenProp1536", "GenProp1673", "GenProp1710", "PWY-5046", "PWY-5084", "R-BTA-204174", "R-BTA-5362517", "R-BTA-6783984", "R-BTA-70895", ...

[ "EC:1.8.1.4", "GP:GenProp0178", "GP:GenProp0630", "GP:GenProp1223", "GP:GenProp1275", "GP:GenProp1348", "GP:GenProp1356", "GP:GenProp1408", "GP:GenProp1439", "GP:GenProp1533", "GP:GenProp1536", "GP:GenProp1673", "GP:GenProp1710", "METACYC:PWY-5046", "METACYC:PWY-5084", "REACTOME:R-BTA-...

78

[ "1bhy", "1dxl", "1ebd", "1jeh", "1lpf", "1lvl", "1ojt", "1v59", "1zmc", "1zmd", "1zy8", "2a8x", "2eq6", "2eq7", "2eq8", "2eq9", "2f5z", "2qae", "2yqu", "3ii4", "3lad", "3rnm", "3urh", "4jdr", "4jq9", "4m52", "5j5z", "5nhg", "5tr3", "5u25", "5u8u", "5u8v"...

52

[]

0

[ "IPR001100" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 517, 38302, 5075, 499 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 10, 1, 1, 1, 1, 5, 2, 1, 7, 7, 1, 1, 9 ]

13

true

Family

Dihydrolipoamide dehydrogenase

Lipoamide_DH

2

IPR006259

6,259

Adenylate kinase subfamily

Adenyl_kin_sub

Family

31,192

false

Adenylate kinase ( ) converts ATP + AMP to ADP + ADP, that is, it uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase ...

[ "GO:0004017", "GO:0005524", "GO:0016776" ]

[ "AMP kinase activity", "ATP binding", "phosphotransferase activity, phosphate group as acceptor" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "NCBIFAM" ]

[ "TIGR01351" ]

[ "adk" ]

[ 31192 ]

1

[ "EC", "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "2.7.4", "2.7.4.3", "GenProp1227", "GenProp1262", "GenProp1343", "GenProp1372", "GenProp1406", "GenProp1484", "GenProp1494", "GenProp1607", "GenProp1617", "GenProp1621", "GenProp1634", "GenProp1650", "GenProp1755", "PWY-7219", "R-BTA-499943", "R-BTA-983231", "R-CEL-499943", "R-...

[ "EC:2.7.4", "EC:2.7.4.3", "GP:GenProp1227", "GP:GenProp1262", "GP:GenProp1343", "GP:GenProp1372", "GP:GenProp1406", "GP:GenProp1484", "GP:GenProp1494", "GP:GenProp1607", "GP:GenProp1617", "GP:GenProp1621", "GP:GenProp1634", "GP:GenProp1650", "GP:GenProp1755", "METACYC:PWY-7219", "REA...

36

[ "1ak2", "1ake", "1aky", "1ank", "1dvr", "1e4v", "1e4y", "1p3j", "1s3g", "1zak", "1zd8", "1zin", "1zio", "1zip", "2ak2", "2ak3", "2aky", "2ar7", "2bbw", "2c9y", "2eck", "2eu8", "2oo7", "2ori", "2osb", "2p3s", "2qaj", "2rgx", "2rh5", "3aky", "3be4", "3dkv"...

102

[]

0

[ "IPR000850" ]

[ "IPR028586", "IPR028587" ]

1

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 577, 19113, 11130, 372 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 24, 1, 4, 2, 2, 9, 6, 1, 8, 9, 2, 1, 35 ]

13

true

Family

Adenylate kinase subfamily

Adenyl_kin_sub

3

IPR006260

6,260

TonB/TolA, C-terminal

TonB/TolA_C

Domain

48,089

false

TonB is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane [ ]. This entry represents the C-terminal domain of TonB. TonB_C interacts with the N-terminal T...

[]

0

[ "NCBIFAM" ]

[ "TIGR01352" ]

[ "tonB_Cterm" ]

[ 48089 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp0543", "R-HSA-9638334", "R-HSA-9638482", "R-HSA-9927020" ]

[ "GP:GenProp0543", "REACTOME:R-HSA-9638334", "REACTOME:R-HSA-9638482", "REACTOME:R-HSA-9927020" ]

4

[ "1ihr", "1lr0", "1qxx", "1u07", "1xx3", "2grx", "2gsk", "2k9k", "2m2k", "5lw8", "6fip", "6i97", "6s3w", "6sly", "7zc8", "8rd6", "9ddo", "9ddp", "9ddq", "9hi3" ]

20

[ "PUB00032540", "PUB00041162", "PUB00066694" ]

[ "15644214", "16741124", "21277822" ]

[ "The solution structure of the C-terminal domain of TonB and interaction studies with TonB box peptides.", "Outer membrane active transport: structure of the BtuB:TonB complex.", "Recent insights into iron import by bacteria." ]

[ 2005, 2006, 2011 ]

3

[]

[ "IPR037682" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 4, 47332, 80, 5, 668 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

TonB/TolA, C-terminal

TonB/TolA_C

8

IPR006261

6,261

dGTP triphosphohydrolase

dGTPase

Family

20,916

false

This entry represents a group of dNTP triphosphohydrolases, which is an class of enzymes capable of hydrolysing deoxynucleoside 5'-triphosphates (dNTPs) into the corresponding deoxynucleosides and tripolyphosphate (PPPi) [ ]. They can be classified into three subgroups [ ]: Type 1: represented by E. coli dGTPase and , ...

[ "GO:0016793" ]

[ "triphosphoric monoester hydrolase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01353" ]

[ "dGTP_triPase" ]

[ 20916 ]

1

[]

0

[ "2dqb", "2pgs", "3bg2", "4x9e", "4xds", "6oi7", "6oiv", "6oiw", "6oix", "6oiy", "7lwz", "7tu0", "7tu1", "7tu2", "7tu3", "7tu4", "7tu5", "7tu6", "7tu7", "7tu8", "7u65", "7u66", "7u67", "7w1f", "9p8s", "9p8t", "9p8u", "9p8v", "9p8w" ]

29

[ "PUB00083218", "PUB00083223", "PUB00083224" ]

[ "19438719", "15496593", "25694425" ]

[ "Two dNTP triphosphohydrolases from Pseudomonas aeruginosa possess diverse substrate specificities.", "Biochemical characterization of TT1383 from Thermus thermophilus identifies a novel dNTP triphosphohydrolase activity stimulated by dATP and dTTP.", "Structure of Escherichia coli dGTP triphosphohydrolase: a h...

[ 2009, 2004, 2015 ]

3

[ "IPR050135" ]

[ "IPR020779", "IPR023023", "IPR023024" ]

1

3

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Siphoviridae sp. ctsfh5", "unclassified sequences" ]

[ 20486, 34, 37, 1, 358 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 1 ]

2

true

Family

dGTP triphosphohydrolase

dGTPase

9

IPR006262

6,262

Cytidine deaminase, homotetrameric

Cyt_deam_tetra

Family

15,301

false

This family represents the small homotetrameric form cytidine deaminase, which is a zinc metalloprotein. It is found in humans and most bacteria. A related homodimeric form, , with a much larger subunit is found in Escherichia coli [ ] and in Arabidopsis thaliana (Mouse-ear cress). Both types may act on deoxycytidine a...

[ "GO:0004126", "GO:0008270" ]

[ "cytidine deaminase activity", "zinc ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR01354" ]

[ "cyt_deam_tetra" ]

[ 15301 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.4.5", "GenProp1221", "GenProp1384", "GenProp1410", "GenProp1465", "GenProp1576", "PWY-6556", "PWY-7181", "PWY-7193", "PWY-7199", "R-DDI-6798695", "R-DDI-73614", "R-HSA-6798695", "R-HSA-73614", "R-MMU-6798695", "R-MMU-73614", "R-SCE-6798695", "R-SCE-73614", "R-SPO-6798695", ...

[ "EC:3.5.4.5", "GP:GenProp1221", "GP:GenProp1384", "GP:GenProp1410", "GP:GenProp1465", "GP:GenProp1576", "METACYC:PWY-6556", "METACYC:PWY-7181", "METACYC:PWY-7193", "METACYC:PWY-7199", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-73614", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-73614", "REA...

20

[ "1jtk", "1mq0", "1r5t", "1uwz", "1ux0", "1ux1", "1zab", "2d30", "2fr5", "2fr6", "3dmo", "3r2n", "7zob", "8x6u", "8x6w", "8x6y" ]

16

[ "PUB00009543", "PUB00021931" ]

[ "10493793", "11851403" ]

[ "Cytidine deaminases from B. subtilis and E. coli: compensating effects of changing zinc coordination and quaternary structure.", "Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution." ]

[ 1999, 2002 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviridae environmental sample", "metagenomes" ]

[ 410, 11413, 3265, 1, 212 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 4, 2, 1, 1, 1, 2, 1, 1 ]

9

true

Family

Cytidine deaminase, homotetrameric

Cyt_deam_tetra

2

IPR006263

6,263

Cytidine deaminase, homodimeric

Cyt_deam_dimer

Family

2,417

false

This family represents the homodimeric form of cytidine deaminase, a zinc metalloprotein found in Escherichia coli [ ] and in Arabidopsis thaliana (Mouse-ear cress). A related, homotetrameric form with a much smaller subunit is found most bacteria and in animals, . Both types may act on deoxycytidine as well as cytidin...

[ "GO:0004126", "GO:0008270" ]

[ "cytidine deaminase activity", "zinc ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR01355" ]

[ "cyt_deam_dimer" ]

[ 2417 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.5.4.5", "GenProp1221", "GenProp1384", "GenProp1410", "GenProp1465", "GenProp1576", "PWY-6556", "PWY-7181", "PWY-7193", "PWY-7199" ]

[ "EC:3.5.4.5", "GP:GenProp1221", "GP:GenProp1384", "GP:GenProp1410", "GP:GenProp1465", "GP:GenProp1576", "METACYC:PWY-6556", "METACYC:PWY-7181", "METACYC:PWY-7193", "METACYC:PWY-7199" ]

10

[ "1af2", "1aln", "1ctt", "1ctu", "4eg2", "6k63", "6l08" ]

7

[ "PUB00009543" ]

[ "10493793" ]

[ "Cytidine deaminases from B. subtilis and E. coli: compensating effects of changing zinc coordination and quaternary structure." ]

[ 1999 ]

1

[]

[ "IPR020797" ]

0

1

0

[ "Bacteria", "Eukaryota" ]

[ 1751, 666 ]

2

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 36, 1, 2, 6 ]

4

true

Family

Cytidine deaminase, homodimeric

Cyt_deam_dimer

7

IPR006266

6,266

UMP-CMP kinase

UMP_CMP_kinase

Family

5,653

false

This entry represents the UMP-CMP kinase subfamily of the adenylate kinase family. UMP-CMP kinase catalyses the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP and is involved in de novo pyrimidine nucleotide biosynthesis [ , ]. In budding yeast, it is also known as Ura6 [ ].

[ "GO:0016776", "GO:0006207", "GO:0006221" ]

[ "phosphotransferase activity, phosphate group as acceptor", "'de novo' pyrimidine nucleobase biosynthetic process", "pyrimidine nucleotide biosynthetic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_03172", "TIGR01359" ]

[ "Adenylate_kinase_UMP_CMP_kin", "UMP_CMP_kin_fam" ]

[ 4665, 5535 ]

2

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.4.14", "GenProp1262", "GenProp1264", "GenProp1307", "GenProp1318", "GenProp1369", "GenProp1494", "GenProp1634", "GenProp1635", "PWY-7176", "R-CEL-499943", "R-DDI-499943", "R-DRE-499943", "R-GGA-499943", "R-HSA-499943", "R-MMU-499943", "R-RNO-499943", "R-SCE-499943", "R-SPO-4...

[ "EC:2.7.4.14", "GP:GenProp1262", "GP:GenProp1264", "GP:GenProp1307", "GP:GenProp1318", "GP:GenProp1369", "GP:GenProp1494", "GP:GenProp1634", "GP:GenProp1635", "METACYC:PWY-7176", "REACTOME:R-CEL-499943", "REACTOME:R-DDI-499943", "REACTOME:R-DRE-499943", "REACTOME:R-GGA-499943", "REACTOME...

20

[ "1qf9", "1tev", "1uke", "1uky", "1ukz", "2ukd", "3ukd", "4ukd", "5ukd", "7e9v" ]

10

[ "PUB00071562", "PUB00071563", "PUB00071564" ]

[ "19645718", "11912132", "1333436" ]

[ "Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans.", "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.", "The adenylate kinase family in yeast: identification of URA6 ...

[ 2009, 2002, 1992 ]

3

[ "IPR000850" ]

[]

1

0

1

[ "Eukaryota" ]

[ 5653 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 3, 2, 3, 2, 2, 1, 9, 5, 1, 1, 16 ]

12

true

Family

UMP-CMP kinase

UMP_CMP_kinase

3

IPR006267

6,267

Adenylate kinase, isozyme 1/5

AK1/5

Family

1,521

false

Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyse the phosphorylation of AMP by using ATP or GTP as phosphate donors.

[ "GO:0004017", "GO:0005524", "GO:0046034", "GO:0005737" ]

[ "AMP kinase activity", "ATP binding", "ATP metabolic process", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR01360" ]

[ "aden_kin_iso1" ]

[ 1521 ]

1

[ "EC", "EC", "EC", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...

[ "2.7.4.3", "2.7.4.4", "2.7.4.6", "GenProp1372", "GenProp1406", "GenProp1607", "PWY-6545", "PWY-7176", "PWY-7184", "PWY-7187", "PWY-7197", "PWY-7198", "PWY-7205", "PWY-7210", "PWY-7219", "PWY-7220", "PWY-7221", "PWY-7222", "PWY-7224", "PWY-7226", "PWY-7227", "PWY-8289", "R...

[ "EC:2.7.4.3", "EC:2.7.4.4", "EC:2.7.4.6", "GP:GenProp1372", "GP:GenProp1406", "GP:GenProp1607", "METACYC:PWY-6545", "METACYC:PWY-7176", "METACYC:PWY-7184", "METACYC:PWY-7187", "METACYC:PWY-7197", "METACYC:PWY-7198", "METACYC:PWY-7205", "METACYC:PWY-7210", "METACYC:PWY-7219", "METACYC:P...

30

[ "1z83", "2bwj", "2c95", "3adk", "5x6k", "5x6l", "5xru", "5xz2", "5ycb", "5ycc", "5ycd", "5ycf", "7de3", "7x7s", "8x1g" ]

15

[ "PUB00068790" ]

[ "23416111" ]

[ "The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase." ]

[ 2013 ]

1

[ "IPR000850" ]

[ "IPR028582" ]

1

0

[ "Bilateria", "Pantoea vagans" ]

[ 1520, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 5, 2, 9 ]

6

true

Family

Adenylate kinase, isozyme 1/5

AK1/5

9

IPR006268

6,268

Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2

DAHP_syn_2

Domain

8,267

false

This entry describes one of at least three types of phospho-2-dehydro-3-deoxyheptonate aldolase (DAHP synthase). This enzyme catalyzes the first of 7 steps in the biosynthesis of chorismate, that last common precursor of all three aromatic amino acids and of PABA, ubiquinone and menaquinone. Some members of this family...

[ "GO:0016832", "GO:0009073" ]

[ "aldehyde-lyase activity", "aromatic amino acid family biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01361" ]

[ "DAHP_synth_Bsub" ]

[ 8267 ]

1

[ "GP" ]

[ "GenProp0001" ]

[ "GP:GenProp0001" ]

1

[ "1rzm", "1vr6", "1vs1", "1zco", "3nvt", "3pg8", "3pg9", "3tfc", "4c1k", "4c1l", "4grs", "5j6f" ]

12

[]

0

[ "IPR006218" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 143, 7994, 10, 120 ]

4

[]

0

true

Domain

Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2

DAHP_syn_2

6

IPR006269

6,269

3-deoxy-8-phosphooctulonate synthase

KDO8P_synthase

Family

14,689

false

These sequences describe 2-dehydro-3-deoxyphosphooctonate aldolase. Alternate names include 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate. phosphoenolpyruvate + D-arabinose 5-phosphate + H 2 O = 2-dehy...

[ "GO:0008676", "GO:0005737" ]

[ "3-deoxy-8-phosphooctulonate synthase activity", "cytoplasm" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_00056", "PTHR21057", "TIGR01362" ]

[ "KDO8P_synth", "", "KDO8P_synth" ]

[ 10993, 14674, 14110 ]

3

[ "EC", "GP", "METACYC", "METACYC" ]

[ "2.5.1.55", "GenProp0204", "PWY-1269", "PWY-7674" ]

[ "EC:2.5.1.55", "GP:GenProp0204", "METACYC:PWY-1269", "METACYC:PWY-7674" ]

4

[ "1d9e", "1fwn", "1fws", "1fwt", "1fww", "1fx6", "1fxp", "1fxq", "1fy6", "1g7u", "1g7v", "1gg0", "1jcx", "1jcy", "1lrn", "1lro", "1lrq", "1o60", "1pck", "1pcw", "1pe1", "1phq", "1phw", "1pl9", "1q3n", "1t8x", "1t96", "1t99", "1x6u", "1x8f", "1zha", "1zji"...

78

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "unclassified sequences" ]

[ 13497, 848, 10, 3, 331 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 1, 3, 5 ]

4

true

Family

3-deoxy-8-phosphooctulonate synthase

KDO8P_synthase

5

IPR006270

6,270

Streptococcal histidine triad repeat

Strep_his_triad_rpt

Repeat

1,354

false

This entry represents a repeated sequence region that includes a His-X-X-His-X-His (histidine triad) motif, which is found in a family of predominantly streptococcal proteins. Members of the family are suggested to cleave human complement component 3, and family member PhpA has been shown in vaccine studies to be a pro...

[]

0

[ "PFAM" ]

[ "PF04270" ]

[ "Strep_his_triad" ]

[ 1354 ]

1

[]

0

[ "2cs7", "3zfj", "6csl" ]

3

[ "PUB00009544" ]

[ "11349048" ]

[ "Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "human gut metagenome" ]

[ 1327, 26, 1 ]

3

[]

0

true

Repeat

Streptococcal histidine triad repeat

Strep_his_triad_rpt

3

IPR006271

6,271

Phosphoserine aminotransferase, Methanosarcina-type

Pser_aminoTfrase_methanosarc

Family

3,349

false

These sequences represent a variant form of the serine biosynthesis enzyme phosphoserine aminotransferase, as found in a small number of distantly related species, including Caulobacter crescentus, Rhizobium loti (Mesorhizobium loti), and the archaeon Methanosarcina barkeri.

[ "GO:0004648", "GO:0006564" ]

[ "O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "L-serine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01365" ]

[ "serC_2" ]

[ 3349 ]

1

[ "EC", "METACYC" ]

[ "2.6.1.52", "PWY-8010" ]

[ "EC:2.6.1.52", "METACYC:PWY-8010" ]

2

[]

0

[]

0

[ "IPR022278" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanosarcina", "unclassified sequences" ]

[ 3134, 164, 22, 29 ]

4

[]

0

true

Family

Phosphoserine aminotransferase, Methanosarcina-type

Pser_aminoTfrase_methanosarc

3

IPR006272

6,272

Phosphoserine aminotransferase, Mycobacterial-type

Pser_aminoTfrase_mycobac

Family

4,552

false

These sequences represent a putative variant form of the serine biosynthesis enzyme phosphoserine aminotransferase, as found in Mycobacterium tuberculosis and related high-GC Gram-positive bacteria.

[ "GO:0004648", "GO:0006564", "GO:0009058" ]

[ "O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "L-serine biosynthetic process", "biosynthetic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01366" ]

[ "serC_3" ]

[ 4552 ]

1

[ "EC", "METACYC" ]

[ "2.6.1.52", "PWY-8010" ]

[ "EC:2.6.1.52", "METACYC:PWY-8010" ]

2

[ "2fyf", "3vom" ]

2

[]

0

[ "IPR022278" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4359, 2, 191 ]

3

[]

0

true

Family

Phosphoserine aminotransferase, Mycobacterial-type

Pser_aminoTfrase_mycobac

9

IPR006273

6,273

Orotate phosphoribosyltransferase, bacterial

Orotate_PRibTrfase_bac

Family

3,081

false

This group of sequences are a distinct clade of bacterial orotate phosphoribosyltransferases. Members include the experimentally determined example from Thermus aquaticus and additional examples from Caulobacter crescentus, Helicobacter pylori (Campylobacter pylori), Rhizobium loti (Mesorhizobium loti), and related spe...

[ "GO:0004588", "GO:0019856" ]

[ "orotate phosphoribosyltransferase activity", "pyrimidine nucleobase biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01367" ]

[ "pyrE_Therm" ]

[ 3081 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC" ]

[ "2.4.2.10", "GenProp0187", "PWY-5686", "PWY-7790", "PWY-7791" ]

[ "EC:2.4.2.10", "GP:GenProp0187", "METACYC:PWY-5686", "METACYC:PWY-7790", "METACYC:PWY-7791" ]

5

[ "4paw" ]

1

[ "PUB00060925", "PUB00060929", "PUB00060930", "PUB00060931", "PUB00060932" ]

[ "22075667", "12872993", "9305779", "8720144", "8487307" ]

[ "Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase.", "Crystallization and preliminary X-ray crystallographic analysis of orotate phosphoribosyltransferase from Helicobacter pylori.", "Sequence and phylogenetic analysis of the Rhizobium legumin...

[ 2012, 2003, 1997, 1995, 1993 ]

5

[ "IPR023031" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2986, 11, 84 ]

3

[]

0

true

Family

Orotate phosphoribosyltransferase, bacterial

Orotate_PRibTrfase_bac

7

IPR006274

6,274

Carbamoyl-phosphate synthase, small subunit

CarbamoylP_synth_ssu

Family

35,951

false

Carbamoyl phosphate synthase (CPSase) is a heterodimeric enzyme composed of a small and a large subunit (with the exception of CPSase III, see below). CPSase catalyses the synthesis of carbamoyl phosphate from biocarbonate, ATP and glutamine or ammonia, and represents the first committed step in pyrimidine and arginine...

[ "GO:0004088", "GO:0006207", "GO:0006541" ]

[ "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity", "'de novo' pyrimidine nucleobase biosynthetic process", "glutamine metabolic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01209", "TIGR01368" ]

[ "CPSase_S_chain", "CPSaseIIsmall" ]

[ 33034, 35827 ]

2

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.5.5", "GenProp0187", "GenProp1129", "GenProp1300", "GenProp1418", "GenProp1427", "GenProp1614", "PWY-5154", "PWY-5686", "PWY-7400", "PWY-7790", "PWY-7791", "R-CEL-500753", "R-DDI-500753", "R-DME-500753", "R-HSA-500753", "R-HSA-70635", "R-MMU-500753", "R-MMU-70635", "R-RNO-...

[ "EC:6.3.5.5", "GP:GenProp0187", "GP:GenProp1129", "GP:GenProp1300", "GP:GenProp1418", "GP:GenProp1427", "GP:GenProp1614", "METACYC:PWY-5154", "METACYC:PWY-5686", "METACYC:PWY-7400", "METACYC:PWY-7790", "METACYC:PWY-7791", "REACTOME:R-CEL-500753", "REACTOME:R-DDI-500753", "REACTOME:R-DME-...

22

[ "1a9x", "1bxr", "1c30", "1c3o", "1ce8", "1cs0", "1jdb", "1kee", "1m6v", "1t36", "5dot", "5dou", "6uel", "6w2j" ]

14

[ "PUB00006448", "PUB00042597", "PUB00074256" ]

[ "10387030", "11212301", "24332717" ]

[ "The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.", "Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product.", "Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD." ]

[ 1999, 1999, 2014 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 801, 24810, 9844, 2, 494 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 8, 1, 7, 2, 1, 11, 6, 2, 3, 10, 2, 2, 10 ]

13

true

Family

Carbamoyl-phosphate synthase, small subunit

CarbamoylP_synth_ssu

9

IPR006275

6,275

Carbamoyl-phosphate synthase, large subunit

CPSase_lsu

Family

34,474

false

This entry represents glutamine-dependent CPSase ( ) from prokaryotes and eukaryotes (CPSase II). Carbamoyl phosphate synthase (CPSase) is a heterodimeric enzyme composed of a small and a large subunit (with the exception of CPSase III, see below). CPSase catalyses the synthesis of carbamoyl phosphate from biocarbonate...

[]

0

[ "HAMAP", "HAMAP", "NCBIFAM" ]

[ "MF_01210_A", "MF_01210_B", "TIGR01369" ]

[ "CPSase_L_chain_A", "CPSase_L_chain_B", "CPSaseII_lrg" ]

[ 14866, 23158, 34316 ]

3

[ "EC", "EC", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.4.16", "6.3.5.5", "GenProp0187", "GenProp1129", "GenProp1300", "GenProp1418", "GenProp1427", "GenProp1614", "PWY-4984", "PWY-5154", "PWY-5686", "PWY-7400", "PWY-7790", "PWY-7791", "R-CEL-500753", "R-DDI-500753", "R-DME-500753", "R-HSA-500753", "R-HSA-70635", "R-MMU-500753"...

[ "EC:6.3.4.16", "EC:6.3.5.5", "GP:GenProp0187", "GP:GenProp1129", "GP:GenProp1300", "GP:GenProp1418", "GP:GenProp1427", "GP:GenProp1614", "METACYC:PWY-4984", "METACYC:PWY-5154", "METACYC:PWY-5686", "METACYC:PWY-7400", "METACYC:PWY-7790", "METACYC:PWY-7791", "REACTOME:R-CEL-500753", "REA...

26

[ "1a9x", "1bxr", "1c30", "1c3o", "1ce8", "1cs0", "1jdb", "1kee", "1m6v", "1t36", "5dot", "5dou", "6uel", "6w2j" ]

14

[ "PUB00006448", "PUB00007868", "PUB00042596", "PUB00042597", "PUB00042598", "PUB00042599", "PUB00042600", "PUB00042601", "PUB00042602" ]

[ "10387030", "10089390", "17397987", "11212301", "8916922", "12379099", "7907330", "17451989", "7932737" ]

[ "The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.", "The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.", "cyclicAMP and glucocorticoid responsiveness of the rat carbamoylphosphate synthetase gene requires the interplay of upstre...

[ 1999, 1999, 2007, 1999, 1996, 2002, 1994, 2007, 1994 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 800, 25464, 7796, 2, 412 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 4, 1, 5, 2, 1, 9, 5, 2, 1, 12, 2, 2, 6 ]

13

true

Family

Carbamoyl-phosphate synthase, large subunit

CPSase_lsu

4

IPR006276

6,276

Cobalamin-independent methionine synthase

Cobalamin-indep_Met_synthase

Family

15,485

false

Methionine synthases catalyse the the final step of methionine biosynthesis. Two apparently unrelated families of proteins catalyse this step: cobalamin-dependent methionine synthase, which catalyses the transfer of a methyl group from N5-methyltetrahydrofolate to L-homocysteine and requires cobalamin as a cofactor (Me...

[ "GO:0003871", "GO:0008270" ]

[ "5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity", "zinc ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_00172", "PIRSF000382", "TIGR01371" ]

[ "Meth_synth", "MeTrfase_B12_ind", "met_syn_B12ind" ]

[ 14130, 15002, 14614 ]

3

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.1.1.14", "GenProp1250", "GenProp1258", "PWY-5041", "PWY-6151", "PWY-6936", "PWY-702" ]

[ "EC:2.1.1.14", "GP:GenProp1250", "GP:GenProp1258", "METACYC:PWY-5041", "METACYC:PWY-6151", "METACYC:PWY-6936", "METACYC:PWY-702" ]

7

[ "1t7l", "1u1h", "1u1j", "1u1u", "1u22", "1xdj", "1xpg", "1xr2", "2nq5", "3bq5", "3bq6", "3l7r", "3ppc", "3ppf", "3ppg", "3pph", "3t0c", "4l5z", "4l61", "4l64", "4l65", "4l6h", "4l6o", "4qqu", "4ztx", "4zty" ]

26

[ "PUB00037682", "PUB00070291" ]

[ "15630480", "1339288" ]

[ "Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication.", "Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem." ]

[ 2005, 1992 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Haloferacaceae", "unclassified sequences" ]

[ 11962, 3470, 5, 48 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 11, 1, 1, 6, 1, 1, 14 ]

7

true

Family

Cobalamin-independent methionine synthase

Cobalamin-indep_Met_synthase

1

IPR006277

6,277

Sarcosine oxidase, alpha subunit

Sarcosine_oxidase_asu

Family

5,359

false

This entry represents the alpha subunit of the heterotetrameric sarcosine oxidases ( ). Five operons of such oxidases are found in Rhizobium loti (Mesorhizobium loti) and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members share the same function. Sarcosine oxidase subunit alph...

[ "GO:0008115", "GO:0046653" ]

[ "sarcosine oxidase activity", "tetrahydrofolate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF037980", "TIGR01372" ]

[ "SoxA", "soxA" ]

[ 5065, 4994 ]

2

[ "EC", "METACYC" ]

[ "1.5.3.24", "PWY-3661" ]

[ "EC:1.5.3.24", "METACYC:PWY-3661" ]

2

[ "1vrq", "1x31", "2gag", "2gah", "3ad7", "3ad8", "3ad9", "3ada" ]

8

[ "PUB00009925", "PUB00033240" ]

[ "7543100", "3790506" ]

[ "Sequence analysis of sarcosine oxidase and nearby genes reveals homologies with key enzymes of folate one-carbon metabolism.", "Bacterial sarcosine oxidase: comparison of two multisubunit enzymes containing both covalent and noncovalent flavin." ]

[ 1995, 1986 ]

2

[ "IPR028896" ]

[]

1

0

1

[ "Bacteria", "Geodia barretti", "unclassified sequences" ]

[ 5334, 1, 24 ]

3

[]

0

true

Family

Sarcosine oxidase, alpha subunit

Sarcosine_oxidase_asu

5

IPR006278

6,278

Sarcosine oxidase subunit beta

SoxB

Family

5,696

false

These sequences represent the beta subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Rhizobium loti (Mesorhizobium loti) and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members share the same function. The ...

[ "GO:0008115", "GO:0046653" ]

[ "sarcosine oxidase activity", "tetrahydrofolate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01373" ]

[ "soxB" ]

[ 5696 ]

1

[ "EC", "METACYC" ]

[ "1.5.3.24", "PWY-3661" ]

[ "EC:1.5.3.24", "METACYC:PWY-3661" ]

2

[ "1vrq", "1x31", "2gag", "2gah", "3ad7", "3ad8", "3ad9", "3ada" ]

8

[ "PUB00033240" ]

[ "3790506" ]

[ "Bacterial sarcosine oxidase: comparison of two multisubunit enzymes containing both covalent and noncovalent flavin." ]

[ 1986 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5640, 3, 53 ]

3

[]

0

true

Family

Sarcosine oxidase subunit beta

SoxB

6

IPR006279

6,279

Sarcosine oxidase, delta subunit, heterotetrameric

SoxD

Family

6,377

false

These sequences represent the delta subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Rhizobium loti (Mesorhizobium loti) and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members share the same function. Sar...

[ "GO:0008115", "GO:0046653" ]

[ "sarcosine oxidase activity", "tetrahydrofolate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "NCBIFAM" ]

[ "PF04267", "TIGR01374" ]

[ "SoxD", "soxD" ]

[ 6377, 3068 ]

2

[ "EC", "METACYC" ]

[ "1.5.3.24", "PWY-3661" ]

[ "EC:1.5.3.24", "METACYC:PWY-3661" ]

2

[ "1vrq", "1x31", "2gag", "2gah", "3ad7", "3ad8", "3ad9", "3ada" ]

8

[ "PUB00033240" ]

[ "3790506" ]

[ "Bacterial sarcosine oxidase: comparison of two multisubunit enzymes containing both covalent and noncovalent flavin." ]

[ 1986 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6278, 6, 93 ]

3

[]

0

true

Family

Sarcosine oxidase, delta subunit, heterotetrameric

SoxD

4

IPR006280

6,280

Sarcosine oxidase, gamma subunit, heterotetrameric

SoxG_het

Family

1,676

false

These sequences represent the gamma subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Rhizobium loti (Mesorhizobium loti) and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members share the same function. The...

[ "GO:0008115", "GO:1901053" ]

[ "sarcosine oxidase activity", "sarcosine catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01375" ]

[ "soxG" ]

[ 1676 ]

1

[ "EC", "METACYC" ]

[ "1.5.3.24", "PWY-3661" ]

[ "EC:1.5.3.24", "METACYC:PWY-3661" ]

2

[ "1vrq", "1x31", "2gag", "2gah", "3ad7", "3ad8", "3ad9", "3ada" ]

8

[ "PUB00033240" ]

[ "3790506" ]

[ "Bacterial sarcosine oxidase: comparison of two multisubunit enzymes containing both covalent and noncovalent flavin." ]

[ 1986 ]

1

[ "IPR007375" ]

[]

1

0

1

[ "Bacteria", "marine sediment metagenome" ]

[ 1675, 1 ]

2

[]

0

true

Family

Sarcosine oxidase, gamma subunit, heterotetrameric

SoxG_het

4

IPR006281

6,281

Sarcosine oxidase, monomeric

SoxA_mon

Family

138

false

This set of sequences describe the alpha subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Rhizobium loti (Mesorhizobium loti) and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members share the same function...

[ "GO:0008115" ]

[ "sarcosine oxidase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_00516" ]

[ "MSOX" ]

[ 138 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.5.3.1", "PWY-3661", "PWY-4722" ]

[ "EC:1.5.3.1", "METACYC:PWY-3661", "METACYC:PWY-4722" ]

3

[ "1el5", "1el7", "1el8", "1el9", "1eli", "1l9c", "1l9d", "1l9e", "2a89", "2gb0", "2gf3", "3bhf", "3bhk", "3m0o", "3m12", "3m13", "3qse", "3qsm", "3qss", "9u3b", "9u3c", "9u3d", "9u3e", "9u3f" ]

24

[ "PUB00033240" ]

[ "3790506" ]

[ "Bacterial sarcosine oxidase: comparison of two multisubunit enzymes containing both covalent and noncovalent flavin." ]

[ 1986 ]

1

[ "IPR045170" ]

[]

1

0

1

[ "Bacillati" ]

[ 138 ]

1

[]

0

true

Family

Sarcosine oxidase, monomeric

SoxA_mon

5

IPR006282

6,282

Thiamin pyrophosphokinase

Thi_PPkinase

Family

13,782

false

This entry represents prokaryotic and eukaryotic thiamin pyrophosphokinase, which converts thiamin (vitamin B1) into the enzyme cofactor thiamin pyrophosphate (TPP, coenzyme B1).

[ "GO:0004788", "GO:0006772" ]

[ "thiamine diphosphokinase activity", "thiamine metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR01378", "cd07995" ]

[ "thi_PPkinase", "TPK" ]

[ 13260, 13661 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.6.2", "GenProp0254", "GenProp1702", "PWY-6898", "PWY-6907", "PWY-6908", "PWY-7356", "R-BTA-196819", "R-CEL-196819", "R-HSA-196819", "R-MMU-196819", "R-SCE-196819", "R-SPO-196819" ]

[ "EC:2.7.6.2", "GP:GenProp0254", "GP:GenProp1702", "METACYC:PWY-6898", "METACYC:PWY-6907", "METACYC:PWY-6908", "METACYC:PWY-7356", "REACTOME:R-BTA-196819", "REACTOME:R-CEL-196819", "REACTOME:R-HSA-196819", "REACTOME:R-MMU-196819", "REACTOME:R-SCE-196819", "REACTOME:R-SPO-196819" ]

13

[ "1ig0", "1ig3", "2f17", "2g9z", "2hh9", "2omk", "3cq9", "3ihk", "3k94", "3l8m", "3lm8", "3mel", "3s4y", "9hjc" ]

14

[ "PUB00009922", "PUB00040489", "PUB00079584", "PUB00079585", "PUB00079590", "PUB00122643", "PUB00122644" ]

[ "11435118", "16365036", "19490098", "6282163", "11899071", "2560632", "7499352" ]

[ "The crystal structure of yeast thiamin pyrophosphokinase.", "Pyrithiamine as a substrate for thiamine pyrophosphokinase.", "Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors.", "Thiamin pyrophosphokinase: structu...

[ 2001, 2006, 2009, 1982, 2001, 1989, 1995 ]

7

[]

[ "IPR016966" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 26, 8635, 4960, 161 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 4, 2, 7, 1, 1, 5, 7, 1, 1, 16 ]

12

true

Family

Thiamin pyrophosphokinase

Thi_PPkinase

3

IPR006283

6,283

Thiamine-monophosphate kinase-like

ThiL-like

Family

21,524

false

This family represents thiamine-monophosphate kinase (ThiL), an enzyme that converts thiamine monophosphate into thiamine pyrophosphate (TPP, coenzyme B1), an enzyme cofactor [ , , , ]. Thiamine monophosphate may be derived from de novo synthesis or from unphosphorylated thiamine, known as vitamin B1. The N-terminal do...

[ "GO:0009030", "GO:0009228" ]

[ "thiamine-phosphate kinase activity", "thiamine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_02128", "PIRSF005303", "PTHR30270", "TIGR01379", "cd02194" ]

[ "TMP_kinase", "Thiam_monoph_kin", "", "thiL", "ThiL" ]

[ 18750, 18094, 21512, 18023, 19038 ]

5

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.4.16", "GenProp0254", "GenProp1144", "GenProp1219", "GenProp1289", "GenProp1457", "GenProp1725", "PWY-6893", "PWY-6894", "PWY-6896", "PWY-6897", "PWY-8457" ]

[ "EC:2.7.4.16", "GP:GenProp0254", "GP:GenProp1144", "GP:GenProp1219", "GP:GenProp1289", "GP:GenProp1457", "GP:GenProp1725", "METACYC:PWY-6893", "METACYC:PWY-6894", "METACYC:PWY-6896", "METACYC:PWY-6897", "METACYC:PWY-8457" ]

12

[ "1vqv", "2yxz", "3c9r", "3c9s", "3c9t", "3c9u", "3mcq", "5cc8", "5cm7", "5dd7", "6mfm", "6xep", "8yks", "8yku" ]

14

[ "PUB00016093", "PUB00050941", "PUB00060746", "PUB00060747" ]

[ "9188462", "18311927", "4567662", "6284709" ]

[ "Characterization of thiL, encoding thiamin-monophosphate kinase, in Salmonella typhimurium.", "Structural studies of thiamin monophosphate kinase in complex with substrates and products.", "Biogenesis of cocarboxylase in Escherichia coli. Partial purification and some properties of thiamine monophosphate kinas...

[ 1997, 2008, 1972, 1982 ]

4

[]

[ "IPR009186", "IPR011413", "IPR011414" ]

0

3

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 1491, 19439, 35, 1, 558 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Thiamine-monophosphate kinase-like

ThiL-like

6

IPR006284

6,284

Glutathione synthetase, prokaryotic

Glut_synth_pro

Family

10,773

false

These are the glutathione synthetases found in Gram-negative bacteria. This gene does not appear to be present in genomes of Gram-positive bacteria. Glutathione synthetase has an ATP-binding domain in the COOH terminus and catalyzes the second step in the glutathione biosynthesis pathway: ATP + gamma-L-glutamyl-L-cyste...

[ "GO:0004363", "GO:0006750" ]

[ "glutathione synthase activity", "glutathione biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00162", "TIGR01380" ]

[ "GSH_S", "glut_syn" ]

[ 10773, 9780 ]

2

[ "EC", "GP", "GP", "METACYC" ]

[ "6.3.2.3", "GenProp0030", "GenProp1359", "PWY-8043" ]

[ "EC:6.3.2.3", "GP:GenProp0030", "GP:GenProp1359", "METACYC:PWY-8043" ]

4

[ "1glv", "1gsa", "1gsh", "2glt" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10617, 25, 131 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glutathione synthetase, prokaryotic

Glut_synth_pro

9

IPR006285

6,285

Ubiquitin-like modifier-activating enzyme Atg7

Atg7

Family

3,877

false

Ubiquitin-like modifier-activating enzyme ATG7 is an E1-like activating enzyme involved in two ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy [ ]. Structurally, ATG7 is a symmetric homodimer with two catalytic cysteine residues and has a combined adenylation/catalytic cysteine-co...

[ "GO:0005737" ]

[ "cytoplasm" ]

[ "cellular_component" ]

1

[ "NCBIFAM" ]

[ "TIGR01381" ]

[ "E1_like_apg7" ]

[ 3877 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-1632852", "R-DDI-6798695", "R-DDI-983168", "R-GGA-1632852", "R-GGA-6798695", "R-GGA-983168", "R-HSA-1632852", "R-HSA-6798695", "R-HSA-6802952", "R-HSA-983168", "R-MMU-1632852", "R-MMU-6798695", "R-MMU-983168", "R-RNO-1632852", "R-RNO-6798695", "R-RNO-983168", "R-SCE-1632852", ...

[ "REACTOME:R-DDI-1632852", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-983168", "REACTOME:R-GGA-1632852", "REACTOME:R-GGA-6798695", "REACTOME:R-GGA-983168", "REACTOME:R-HSA-1632852", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-6802952", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-1632852", "REACTOME:R...

22

[ "3vh1", "3vh2", "4gsk", "4gsl" ]

4

[ "PUB00066530", "PUB00095360", "PUB00095361", "PUB00095362", "PUB00095363", "PUB00108655", "PUB00163357", "PUB00163358", "PUB00163359", "PUB00163360", "PUB00163361", "PUB00163362" ]

[ "17204848", "29937374", "21339326", "17726112", "19910529", "18704115", "17475204", "19139628", "22291845", "22499945", "23638598", "34161705" ]

[ "ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes.", "Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1.", "The autophagy protein Atg7 is essential for hematopoietic stem ce...

[ 2007, 2018, 2011, 2007, 2009, 2008, 2007, 2009, 2012, 2012, 2013, 2021 ]

12

[ "IPR045886" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3877 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 4, 5, 2, 2, 11, 1, 1 ]

11

true

Family

Ubiquitin-like modifier-activating enzyme Atg7

Atg7

2

IPR006286

6,286

Deglycase PfpI-like

C56_PfpI-like

Family

20,634

false

PfpI from Pyrococcus furiosus functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins [ ]. Pfpi-like proteins have been found in bacteria, archaea, in some plants and in amoebae. The structure of P. horikoshii PfpI shows an α/β sandwich fold, which consists of a central β sheet flanke...

[]

0

[ "PROFILE", "PANTHER", "NCBIFAM" ]

[ "PS51276", "PTHR42733", "TIGR01382" ]

[ "PEPTIDASE_C56_PFPI", "", "PfpI" ]

[ 19491, 20459, 18489 ]

3

[]

0

[ "1g2i", "1oi4", "2vrn", "3fse", "3l18", "3uk7", "4ofw", "4ogg", "4y0n", "4y1e", "4y1f", "4y1g", "4y1r", "5tw0", "5txw", "6f2f", "6f2h", "6hf6", "6q3t", "7qo8", "7r66", "8r3n" ]

22

[ "PUB00017672", "PUB00079195", "PUB00086596", "PUB00086658", "PUB00086659" ]

[ "11114201", "26774339", "28596309", "24330391", "27530919" ]

[ "Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution.", "The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal.", "Guanine glycation repair by DJ-1/Park7 and its bacterial homologs.", "Methylglyoxal ...

[ 2000, 2016, 2017, 2014, 2016 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 613, 18546, 1356, 119 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 12, 1, 6, 7 ]

4

true

Family

Deglycase PfpI-like

C56_PfpI-like

5

IPR006287

6,287

Protein/nucleic acid deglycase DJ-1

DJ-1

Family

10,231

false

Glycation is a nonenzymatic covalent reaction between proteins and endogenous reducing sugars or dicarbonyls (methylglyoxal, glyoxal) that results in protein inactivation. DJ-1 was described in vitro as a protein deglycase that repaired methylglyoxal-and glyoxal-glycated proteins [ , ]. Since then there have been repor...

[]

0

[ "NCBIFAM" ]

[ "TIGR01383" ]

[ "not_thiJ" ]

[ 10231 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3899300", "R-BTA-9646399", "R-CEL-3899300", "R-CEL-9646399", "R-DME-9646399", "R-DRE-9646399", "R-HSA-3899300", "R-HSA-9613829", "R-HSA-9615710", "R-HSA-9646399", "R-MMU-3899300", "R-MMU-9646399", "R-RNO-3899300", "R-RNO-9646399" ]

[ "REACTOME:R-BTA-3899300", "REACTOME:R-BTA-9646399", "REACTOME:R-CEL-3899300", "REACTOME:R-CEL-9646399", "REACTOME:R-DME-9646399", "REACTOME:R-DRE-9646399", "REACTOME:R-HSA-3899300", "REACTOME:R-HSA-9613829", "REACTOME:R-HSA-9615710", "REACTOME:R-HSA-9646399", "REACTOME:R-MMU-3899300", "REACTOM...

14

[ "1j42", "1p5f", "1pdv", "1pdw", "1pe0", "1q2u", "1soa", "1ucf", "2ab0", "2or3", "2r1t", "2r1u", "2r1v", "2rk3", "2rk4", "2rk6", "3b36", "3b38", "3b3a", "3bwe", "3cy6", "3cyf", "3cz9", "3cza", "3ezg", "3f71", "3ot1", "3sf8", "4bte", "4e08", "4mnt", "4mtc"...

94

[ "PUB00079190", "PUB00079191", "PUB00079193", "PUB00079194", "PUB00079195", "PUB00084366", "PUB00084367", "PUB00086596", "PUB00086597" ]

[ "25416785", "12446870", "26995087", "20889753", "26774339", "27903648", "28013050", "28596309", "28706026" ]

[ "Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.", "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.", "The Parkinsonism-associated protein DJ-1/Park7 prevent...

[ 2015, 2003, 2016, 2010, 2016, 2017, 2017, 2017, 2017 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 17, 5864, 4268, 82 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 16, 2, 1, 3, 1, 3, 3, 13, 5, 17 ]

10

true

Family

Protein/nucleic acid deglycase DJ-1

DJ-1

3

IPR006288

6,288

Transcription factor S/S1

TFS

Family

1,394

false

This entry represents the transcription factor S, a protein related in size and sequence to DNA-directed RNA polymerase subunit M, and in sequence and function to the much larger eukaryotic transcription factor IIS (TFIIS). Although originally suggested to be a subunit of the archaeal RNA polymerase (known as archaeal ...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR01384" ]

[ "TFS_arch" ]

[ 1394 ]

1

[]

0

[ "1qyp" ]

1

[ "PUB00009536", "PUB00078615", "PUB00099581" ]

[ "10777522", "15130130", "29203770" ]

[ "Transcription factor S, a cleavage induction factor of the archaeal RNA polymerase.", "Transcriptional fidelity and proofreading in Archaea and implications for the mechanism of TFS-induced RNA cleavage.", "The transcript cleavage factor paralogue TFS4 is a potent RNA polymerase inhibitor." ]

[ 2000, 2004, 2017 ]

3

[ "IPR012164" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1164, 6, 198, 26 ]

4

[ "Arabidopsis thaliana" ]

[ 7 ]

1

true

Family

Transcription factor S/S1

TFS

4

IPR006289

6,289

Transcription elongation factor, TFIIS

TFSII

Family

5,623

false

Transcription elongation factor IIS (TFIIS) is a component of RNA polymerase II preinitiation complexes, and is required for preinitiation complex assembly and stability [ ]. The association of TFIIS with a promoter depends on functional preinitiation complex components including Mediator and the SAGA complex [ ]. TFII...

[ "GO:0003676", "GO:0006368", "GO:0005634" ]

[ "nucleic acid binding", "transcription elongation by RNA polymerase II", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01385" ]

[ "TFSII" ]

[ 5623 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-75955", "R-CEL-112382", "R-CEL-674695", "R-CEL-6781823", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-6796648", "R-CEL-75955", "R-DME-112382", "R-DME-674695", "R-DME-6781823", "R-DME-6782135", "R...

[ "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-75955", "REACTOME:R-CEL-112382", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-6781823", "REACTOME:R-CEL-6782135", "REACTOME:R-CEL-6782210", "REACTOME:R-C...

57

[ "1pqv", "1y1v", "1y1y", "3gtm", "3po3", "5fmf", "5iy6", "5iy7", "5iy8", "5iya", "5iyb", "5iyc", "6o9l", "7ui9", "7uif", "7uio", "7unc", "7und", "8a40", "8uis", "8umh", "8umi", "8uoq", "8uot", "9egx", "9egy", "9egz", "9eh0", "9eh1", "9eh2", "9j0n", "9s0u"...

33

[ "PUB00042911", "PUB00042912", "PUB00042913", "PUB00042914" ]

[ "17913884", "17901206", "16648364", "10940308" ]

[ "The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes.", "TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo.", "A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised f...

[ 2007, 2007, 2006, 2000 ]

4

[ "IPR035100" ]

[]

1

0

1

[ "Eukaryota" ]

[ 5623 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 8, 2, 9, 11, 1, 6, 11, 1, 1, 8 ]

12

true

Family

Transcription elongation factor, TFIIS

TFSII

5

IPR006290

6,290

Heavy metal sensor kinase

CztS_silS_copS

Family

8,479

false

Members of this family contain a sensor histidine kinase domain ( ) and a domain found in bacterial signal proteins ( ). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, ca...

[ "GO:0004673", "GO:0000160", "GO:0016020" ]

[ "protein histidine kinase activity", "phosphorelay signal transduction system", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01386" ]

[ "cztS_silS_copS" ]

[ 8479 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[ "7zp0" ]

1

[ "PUB00090185", "PUB00090186", "PUB00090187" ]

[ "22348296", "25568260", "27983483" ]

[ "Regulation of Cu(I)/Ag(I) efflux genes in Escherichia coli by the sensor kinase CusS.", "Cooperative regulation of the common target genes between H₂O₂-sensing YedVW and Cu²⁺-sensing CusSR in Escherichia coli.", "Cross-regulation between two common ancestral response regulators, HprR and CusR, in Escherichia c...

[ 2012, 2015, 2017 ]

3

[ "IPR050428" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8422, 7, 50 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Heavy metal sensor kinase

CztS_silS_copS

5

IPR006291

6,291

Transcriptional regulatory protein CusR-like, heavy metal response

CusR-like

Family

7,585

false

This family represents Transcriptional regulatory protein CusR from Escherichia coli ([ , ]) and similar sequences predominantly found in proteobacteria. Proteins in this entry contain a response regulator receiver domain ( ) and an associated transcriptional regulatory region ( ). This group is separated phylogenetica...

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01387" ]

[ "cztR_silR_copR" ]

[ 7585 ]

1

[]

0

[]

0

[ "PUB00090186", "PUB00090187" ]

[ "25568260", "27983483" ]

[ "Cooperative regulation of the common target genes between H₂O₂-sensing YedVW and Cu²⁺-sensing CusSR in Escherichia coli.", "Cross-regulation between two common ancestral response regulators, HprR and CusR, in Escherichia coli." ]

[ 2015, 2017 ]

2

[ "IPR039420" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7531, 8, 46 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Transcriptional regulatory protein CusR-like, heavy metal response

CusR-like

3

IPR006293

6,293

DNA helicase, ATP-dependent, RecQ type, bacterial

DNA_helicase_ATP-dep_RecQ_bac

Family

18,862

false

The ATP-dependent DNA helicase RecQ ( ) is involved in genome maintenance [ ]. All homologues tested to date unwind paired DNA, translocating in a 3' to 5' direction and several have a preference for forked or 4-way DNA structures (e.g. Holliday junctions) or for G-quartet DNA. The yeast protein, Sgs1, is present in nu...

[ "GO:0003678", "GO:0006310", "GO:0009432" ]

[ "DNA helicase activity", "DNA recombination", "SOS response" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01389" ]

[ "recQ" ]

[ 18862 ]

1

[ "EC", "GP" ]

[ "5.6.2.4", "GenProp0491" ]

[ "EC:5.6.2.4", "GP:GenProp0491" ]

2

[ "1oyw", "1oyy", "4q47", "4q48", "4tmu", "6crm" ]

6

[ "PUB00009985" ]

[ "12354611" ]

[ "RecQ helicases: at the heart of genetic stability." ]

[ 2002 ]

1

[ "IPR004589" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 18610, 9, 112, 131 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA helicase, ATP-dependent, RecQ type, bacterial

DNA_helicase_ATP-dep_RecQ_bac

7

IPR006294

6,294

2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase

Cyc_nuc_PDE_nucleotidase

Family

2,420

false

These sequences represent 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidases; it is a bifunctional enzyme localized to the periplasm of Gram-negative bacteria. 2',3'-cyclic-nucleotide 2'-phosphodiesters are intermediates formed during the hydrolysis of RNA by the ribonuclease I, which is also found in the pe...

[ "GO:0008663", "GO:0009117" ]

[ "2',3'-cyclic-nucleotide 2'-phosphodiesterase activity", "nucleotide metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01390" ]

[ "CycNucDiestase" ]

[ 2420 ]

1

[ "EC", "EC" ]

[ "3.1.3.6", "3.1.4.16" ]

[ "EC:3.1.3.6", "EC:3.1.4.16" ]

2

[]

0

[ "PUB00009537" ]

[ "11160814" ]

[ "Cloning and characterization of the gene encoding periplasmic 2',3'-cyclic phosphodiesterase of Yersinia enterocolitica O:8." ]

[ 2001 ]

1

[ "IPR006179" ]

[]

1

0

1

[ "Bacteria" ]

[ 2420 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase

Cyc_nuc_PDE_nucleotidase

3

IPR006295

6,295

DNA primase, DnaG

DNA_primase_DnaG

Domain

26,541

false

Proteins with this domain are DNA primases, a ubiquitous bacteria protein. Most DNA primases contain nearly two hundred additional residues C-terminal to the region represented here, but conservation between species is poor. DNA primase synthesises the RNA primers for the Okazaki fragments in lagging strand DNA synthes...

[ "GO:0006269" ]

[ "DNA replication, synthesis of primer" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR01391" ]

[ "dnaG" ]

[ 26541 ]

1

[ "EC", "GP" ]

[ "2.7.7.101", "GenProp0806" ]

[ "EC:2.7.7.101", "GP:GenProp0806" ]

2

[ "1dd9", "1dde", "1eqn", "2au3", "3b39", "4e2k", "4edg", "4edk", "4edr", "4edt", "4edv", "4ee1", "5guj", "5vaz" ]

14

[ "PUB00028344", "PUB00033248", "PUB00033249", "PUB00033250", "PUB00033251", "PUB00033252" ]

[ "10741967", "1531480", "8702921", "8917517", "9989506", "2411935" ]

[ "Structure of the RNA polymerase domain of E. coli primase.", "Coordinated leading- and lagging-strand synthesis at the Escherichia coli DNA replication fork. III. A polymerase-primase interaction governs primer size.", "The interaction between helicase and primase sets the replication fork clock.", "Direct p...

[ 2000, 1992, 1996, 1996, 1999, 1985 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 26015, 49, 32, 445 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DNA primase, DnaG

DNA_primase_DnaG

2

IPR006297

6,297

Elongation factor 4

EF-4

Family

33,830

false

Elongation factor 4, also known as ribosomal back-translocase LepA, is required for accurate and efficient protein synthesis under certain stress conditions. Its function is not clear. However, it may act as a fidelity factor of the translation reaction, by catalysing a one-codon backward translocation of tRNAs on impr...

[ "GO:0005525" ]

[ "GTP binding" ]

[ "molecular_function" ]

1

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_00071", "PTHR43512", "TIGR01393" ]

[ "LepA", "", "lepA" ]

[ 30792, 33769, 30130 ]

3

[]

0

[ "2ywe", "2ywf", "2ywg", "2ywh", "3cb4", "3deg", "3jcd", "3jce", "4w2e", "5imq", "5imr", "5j8b" ]

12

[ "PUB00056782", "PUB00056783", "PUB00056784" ]

[ "17110332", "20045415", "18442968" ]

[ "The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome.", "Interrupted catalysis: the EF4 (LepA) effect on back-translocation.", "The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions." ]

[ 2006, 2010, 2008 ]

3

[]

[ "IPR027518" ]

0

1

0

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 26880, 6165, 6, 779 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 7, 1, 5, 3, 1, 2, 5, 1, 2, 3, 1, 1, 9 ]

13

true

Family

Elongation factor 4

EF-4

8

IPR006298

6,298

GTP-binding protein BipA

BipA

Family

24,846

false

This family includes the GTP-binding protein BipA or TypA (Tyrosine phosphorylated protein A (TypA), also known as 50S ribosomal subunit assembly factor BipA) from bacteria and its homologue from Arabidopsis (putative elongation factor TypA-like SVR3). BipA is a 50S ribosomal subunit assembly protein with GTPase activi...

[ "GO:0003924", "GO:0005525" ]

[ "GTPase activity", "GTP binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00849", "TIGR01394" ]

[ "BipA", "TypA_BipA" ]

[ 22785, 24834 ]

2

[ "EC" ]

[ "3.6.5.-" ]

[ "EC:3.6.5.-" ]

1

[ "4zci", "4zcl", "4zcm", "5a9v", "5a9w", "5a9x", "5a9y", "5a9z", "5aa0", "8ewh" ]

10

[ "PUB00043024", "PUB00085803", "PUB00092580", "PUB00101692", "PUB00101693", "PUB00101694", "PUB00101695" ]

[ "9622352", "12675808", "26163516", "21187014", "21208309", "19803466", "25777676" ]

[ "BipA: a tyrosine-phosphorylated GTPase that mediates interactions between enteropathogenic Escherichia coli (EPEC) and epithelial cells.", "Co-ordination of pathogenicity island expression by the BipA GTPase in enteropathogenic Escherichia coli (EPEC).", "Structural and Functional Analysis of BipA, a Regulator...

[ 1998, 2003, 2015, 2010, 2011, 2009, 2015 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 23299, 1225, 322 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 12, 1, 6, 8 ]

4

true

Family

GTP-binding protein BipA

BipA

6

IPR006300

6,300

Flagellar basal-body rod protein FlgB

FlgB

Family

12,016

false

FlgB is a flagellar basal-body protein that along with FlgCFG composes the rod of bacterial flagellin [ ].

[ "GO:0071973", "GO:0030694" ]

[ "bacterial-type flagellum-dependent cell motility", "bacterial-type flagellum basal body, rod" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF002889", "TIGR01396" ]

[ "Rod_FlgB", "FlgB" ]

[ 11811, 10288 ]

2

[ "GP" ]

[ "GenProp0880" ]

[ "GP:GenProp0880" ]

1

[ "7bin", "7cg0", "7cgo", "7e80", "7e82", "7nvg", "8wk3", "8wk4", "8wkk", "8wkq", "8wl2", "8wlh", "8wln", "8wlq", "8wlt", "8wo5", "8woe", "8z5s", "8z5u", "8z5w", "8z5x", "8z60" ]

22

[ "PUB00003254", "PUB00033604" ]

[ "2129540", "15136044" ]

[ "FlgB, FlgC, FlgF and FlgG. A family of structurally related proteins in the flagellar basal body of Salmonella typhimurium.", "In vitro characterization of FlgB, FlgC, FlgF, FlgG, and FliE, flagellar basal body proteins of Salmonella." ]

[ 1990, 2004 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 11866, 22, 128 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar basal-body rod protein FlgB

FlgB

4

IPR006302

6,302

Type III secretion protein HrcV

T3SS_HrcV

Family

3,368

false

Members of this family are closely homologous to the flagellar biosynthesis protein FlhA and should all participate in type III secretion systems. Examples include InvA (Salmonella enterica), LcrD (Yersinia enterocolitica), HrcV (Xanthomonas), etc. Type III secretion systems resemble flagellar biogenesis systems, and m...

[ "GO:0015031", "GO:0016020" ]

[ "protein transport", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01399" ]

[ "hrcV" ]

[ 3368 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "7alw", "7awa" ]

2

[]

0

[ "IPR001712" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3355, 4, 9 ]

3

[]

0

true

Family

Type III secretion protein HrcV

T3SS_HrcV

1

IPR006303

6,303

Flagellar biosynthesis protein FliR

FliR

Family

10,310

false

This entry represents the bacterial flagellar biosynthesis protein FliR [ , ].

[ "GO:0044780", "GO:0016020" ]

[ "bacterial-type flagellum assembly", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01400" ]

[ "fliR" ]

[ 10310 ]

1

[ "GP" ]

[ "GenProp0879" ]

[ "GP:GenProp0879" ]

1

[ "6f2d", "6r69", "6s3l", "6s3r", "6s3s", "7bin", "7cgo", "7e80", "7nvg", "8wk3", "8wkk", "8wkq", "8wl2", "8wlh", "8wln", "8wlq", "8wlt", "8wo5", "8woe", "8z5s", "8z5u", "8z5x", "8z60", "9k29" ]

24

[ "PUB00067601", "PUB00067602" ]

[ "9324257", "9426140" ]

[ "The FliO, FliP, FliQ, and FliR proteins of Salmonella typhimurium: putative components for flagellar assembly.", "The FliP and FliR proteins of Salmonella typhimurium, putative components of the type III flagellar export apparatus, are located in the flagellar basal body." ]

[ 1997, 1997 ]

2

[ "IPR002010" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10210, 4, 96 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar biosynthesis protein FliR

FliR

3

IPR006304

6,304

Type III secretion protein SpaR/YscT

T3SS_SpaR/YscT

Family

3,469

false

These sequences represent members of bacterial type III secretion systems homologous to the flagellar biosynthetic protein FliR ( ).

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "NCBIFAM" ]

[ "TIGR01401" ]

[ "fliR_like_III" ]

[ 3469 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "6pem", "6pep", "6q14", "6q15", "6q16", "6r6b", "6rwy", "7agx", "7ah9", "7ahi", "8axk" ]

11

[]

0

[ "IPR002010" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3462, 2, 5 ]

3

[]

0

true

Family

Type III secretion protein SpaR/YscT

T3SS_SpaR/YscT

6

IPR006305

6,305

Flagellar biosynthesis protein FliQ

FliQ

Family

9,825

false

These sequences represent FliQ, a protein involved in biosynthesis of bacterial flagella [ , ].

[ "GO:0044780", "GO:0016020" ]

[ "bacterial-type flagellum assembly", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01402" ]

[ "fliQ" ]

[ 9825 ]

1

[ "GP" ]

[ "GenProp0879" ]

[ "GP:GenProp0879" ]

1

[ "6f2d", "6r69", "6s3l", "6s3s", "7bin", "7cgo", "7e80", "7nvg", "8wk3", "8wkk", "8wkq", "8wl2", "8wlh", "8wln", "8wlq", "8wlt", "8wo5", "8woe", "8z5s", "8z5u", "8z5x", "8z60", "9k29" ]

23

[ "PUB00067601", "PUB00067603" ]

[ "9324257", "10234819" ]

[ "The FliO, FliP, FliQ, and FliR proteins of Salmonella typhimurium: putative components for flagellar assembly.", "Functional analysis of the roles of FliQ and FlhB in flagellar expression in Helicobacter pylori." ]

[ 1997, 1999 ]

2

[ "IPR002191" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9701, 2, 122 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar biosynthesis protein FliQ

FliQ

5

IPR006306

6,306

Type III secretion protein HrpO

T3SS_HrpO

Family

2,933

false

This is one of several families of proteins related to bacterial flagellar biosynthesis proteins and involved in bacterial type III protein secretion systems, and is represented by HrpO [ ]. This family is homologous to, but separate from, the flagellar biosynthetic protein FliQ.

[ "GO:0009306", "GO:0016020" ]

[ "protein secretion", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01403" ]

[ "fliQ_rel_III" ]

[ 2933 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "6pem", "6pep", "6q14", "6q15", "6q16", "6r6b", "6rwy", "7agx", "7ah9", "7ahi", "8axk" ]

11

[ "PUB00087517" ]

[ "18836182" ]

[ "Evidence for a coiled-coil interaction mode of disordered proteins from bacterial type III secretion systems." ]

[ 2008 ]

1

[ "IPR002191" ]

[]

1

0

1

[ "Bacteria", "Bracon brevicornis", "metagenomes" ]

[ 2927, 1, 5 ]

3

[]

0

true

Family

Type III secretion protein HrpO

T3SS_HrpO

7

IPR006307

6,307

Type III exporter system, secretion apparatus protein BsaZ-like

BsaZ-like

Family

2,684

false

This entry represents a group of proteins related to bacterial flagellar biosynthesis proteins and involved in bacterial type III protein secretion systems, including Secretion apparatus protein BsaZ from Burkholderia pseudomallei. BsaZ is involved in the intracellular replication of invading bacteria inside the host c...

[ "GO:0009306", "GO:0016020" ]

[ "protein secretion", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01404" ]

[ "FlhB_rel_III" ]

[ 2684 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "8axk" ]

1

[ "PUB00104257", "PUB00150963" ]

[ "26520801", "18443088" ]

[ "Type III Secretion: Building and Operating a Remarkable Nanomachine.", "Burkholderia pseudomallei type III secretion system mutants exhibit delayed vacuolar escape phenotypes in RAW 264.7 murine macrophages." ]

[ 2016, 2008 ]

2

[ "IPR006135" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 2680, 2, 2 ]

3

[]

0

true

Family

Type III exporter system, secretion apparatus protein BsaZ-like

BsaZ-like

2

IPR006308

6,308

DNA polymerase III, alpha subunit, PolC-type, Gram-positive bacteria

Pol_III_a_PolC-type_gram_pos

Family

5,855

false

These are the polypeptide chains of DNA polymerase III. Full-length homologues of this protein are found mainly in Gram-positive lineages, including the Mycoplasmas. This protein is designated alpha chain and given the gene symbol polC, but is not a full-length homologue of other polC genes. The N-terminal region of ab...

[ "GO:0003677", "GO:0003887", "GO:0006260", "GO:0005737" ]

[ "DNA binding", "DNA-directed DNA polymerase activity", "DNA replication", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "HAMAP", "NCBIFAM" ]

[ "MF_00356", "TIGR01405" ]

[ "DNApol_PolC", "polC_Gram_pos" ]

[ 5855, 5681 ]

2

[ "EC", "GP" ]

[ "2.7.7.7", "GenProp0263" ]

[ "EC:2.7.7.7", "GP:GenProp0263" ]

2

[ "3f2b", "3f2c", "3f2d", "9qpc", "9qrl", "9qrn" ]

6

[]

0

[ "IPR004805" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5841, 4, 10 ]

3

[]

0

true

Family

DNA polymerase III, alpha subunit, PolC-type, Gram-positive bacteria

Pol_III_a_PolC-type_gram_pos

8

IPR006309

6,309

DNA polymerase 3, epsilon subunit

DnaQ_proteo

Family

9,690

false

These represent DnaQ, the DNA polymerase III epsilon subunit, as found in most Proteobacteria. It consists largely of an exonuclease region as described in . In Gram-positive bacteria, closely related regions are found both in the Gram-positive type DNA polymerase III alpha subunit and as an additional N-terminal domai...

[ "GO:0003677", "GO:0003887", "GO:0006260" ]

[ "DNA binding", "DNA-directed DNA polymerase activity", "DNA replication" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR01406", "cd06131" ]

[ "dnaQ_proteo", "DNA_pol_III_epsilon_Ecoli_like" ]

[ 9616, 9666 ]

2

[ "EC", "GP", "GP" ]

[ "2.7.7.7", "GenProp0263", "GenProp1155" ]

[ "EC:2.7.7.7", "GP:GenProp0263", "GP:GenProp1155" ]

3

[ "1j53", "1j54", "2gui", "2ido", "2xy8", "5fku", "5fkv", "5fkw", "5m1s" ]

9

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9549, 26, 115 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA polymerase 3, epsilon subunit

DnaQ_proteo

6

IPR006310

6,310

3'-5' exonuclease DinG

DinG

Family

3,370

false

Canonical DinG is a bacterial helicase with 5'->3' polarity. In the bacilli and clostridia, the DinG helicase has become fused with an N-terminal exonuclease domain and lacks the FeS-binding domain essential for the helicase activity. Instead of being an helicase, the enzyme is a 3'->5' exonuclease acting on single-str...

[ "GO:0005524", "GO:0008408" ]

[ "ATP binding", "3'-5' exonuclease activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_02206", "TIGR01407" ]

[ "DinG_exonucl", "dinG_rel" ]

[ 3247, 3220 ]

2

[]

0

[ "8zef", "9ii8" ]

2

[ "PUB00088400" ]

[ "22166102" ]

[ "Staphylococcus aureus DinG, a helicase that has evolved into a nuclease." ]

[ 2012 ]

1

[ "IPR045028" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 3365, 5 ]

2

[]

0

true

Family

3'-5' exonuclease DinG

DinG

3

IPR006311

6,311

Twin-arginine translocation pathway, signal sequence

TAT_signal

Conserved_site

625,407

false

This entry represents the Tat signal, from the methionine to the A-x-A short motif. The twin-arginine translocation (Tat) pathway serves the role of transporting folded proteins across energy-transducing membranes [ ]. Homologues of the genes that encode the transport apparatus occur in archaea, bacteria, chloroplasts,...

[]

0

[ "PROFILE" ]

[ "PS51318" ]

[ "TAT" ]

[ 625407 ]

1

[ "REACTOME" ]

[ "R-HSA-9638482" ]

[ "REACTOME:R-HSA-9638482" ]

1

[ "1dmr", "1e18", "1e5v", "1e60", "1e61", "1h2a", "1h5n", "1h6a", "1h6b", "1h6c", "1h6d", "1hfe", "1kqf", "1kqg", "1psc", "1tmo", "1wx2", "1wx4", "1wx5", "1wxc", "1zrt", "2ahk", "2ahl", "2cnc", "2dmr", "2fyn", "2hdw", "2hzk", "2hzl", "2ivf", "2iwf", "2iwk"...

277

[ "PUB00043729", "PUB00043730", "PUB00043731", "PUB00043732", "PUB00043733", "PUB00043734", "PUB00043735" ]

[ "16322447", "12029389", "16092521", "16756481", "15546663", "15802249", "12427925" ]

[ "Protein translocation across biological membranes.", "Sequence and phylogenetic analyses of the twin-arginine targeting (Tat) protein export system.", "Sec-dependent protein translocation across biological membranes: evolutionary conservation of an essential protein transport pathway (review).", "The bacteri...

[ 2005, 2002, 2005, 2006, 2004, 2005, 2002 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "Viruses", "unclassified sequences" ]

[ 22688, 591856, 5671, 2, 139, 5051 ]

6

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Homo sapiens", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 22, 2, 1, 74, 1, 99 ]

7

true

Conserved_site

Twin-arginine translocation pathway, signal sequence

TAT_signal

9

IPR006312

6,312

Sec-independent protein translocase protein TatA/E

TatA/E

Family

29,248

false

TatA and TatE are highly related proteins and appear to overlap in functionality [ ]. Translocation occurred in single mutants of either TatA or TatE, though much less efficiently, but double mutants showed no detectable translocation. Translocation of proteins across the two membranes of Gram-negative bacteria can be ...

[ "GO:0043953", "GO:0016020" ]

[ "protein transport by the Tat complex", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00236", "TIGR01411" ]

[ "TatA_E", "tatAE" ]

[ 28100, 26017 ]

2

[ "GP", "GP" ]

[ "GenProp0127", "GenProp1136" ]

[ "GP:GenProp0127", "GP:GenProp1136" ]

2

[ "2l16", "2lzr", "2lzs", "2mn6", "2mn7", "7b7o", "9e07" ]

7

[ "PUB00007662", "PUB00007663" ]

[ "9649434", "10652088" ]

[ "Overlapping functions of components of a bacterial Sec-independent protein export pathway.", "The Tat protein export pathway." ]

[ 1998, 2000 ]

2

[ "IPR003369" ]

[ "IPR024905" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 686, 26788, 1257, 517 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 2, 2, 17 ]

4

true

Family

Sec-independent protein translocase protein TatA/E

TatA/E

1

IPR006313

6,313

Deferrochelatase

EfeB/EfeN

Family

6,595

false

This entry represents a small family of proteins with a typical Tat (twin-arginine translocation) signal sequence, suggesting that the family is exported in a folded state, perhaps with a bound redox cofactor. Proteins in this family include deferrochelatase/peroxidase EfeB, which is involved in the recovery of exogeno...

[ "GO:0004601", "GO:0020037", "GO:0033212" ]

[ "peroxidase activity", "heme binding", "iron import into cell" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01412" ]

[ "tat_substr_1" ]

[ 6595 ]

1

[ "EC", "EC", "METACYC", "REACTOME" ]

[ "1.11.1.-", "4.98.1.1", "PWY-5292", "R-HSA-9638482" ]

[ "EC:1.11.1.-", "EC:4.98.1.1", "METACYC:PWY-5292", "REACTOME:R-HSA-9638482" ]

4

[ "2y4d", "2y4e", "2y4f", "3o72", "4grc", "4gt2", "5map", "5mjh", "6gzw", "6i43", "6i7c", "6i7z", "6i8e", "6i8i", "6i8j", "6i8k", "6i8o", "6i8p", "6i8q", "6i91", "6ibn", "6jbn", "6kmm", "6kmn", "6q31", "6q34", "6q3d", "6q3e", "6tb8", "7dlk", "7e5q", "7pkx"...

61

[ "PUB00070842", "PUB00099956", "PUB00100762" ]

[ "19564607", "21324904", "32971035" ]

[ "Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact.", "Crystal structure and biochemical features of EfeB/YcdB from Escherichia coli O157: ASP235 plays divergent roles in different enzyme-catalyzed processes.", "Characterization of dye-decolorizing peroxidase from Bacillus subtilis." ]

[ 2009, 2011, 2020 ]

3

[ "IPR006314" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6573, 4, 18 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Deferrochelatase

EfeB/EfeN

6

IPR006314

6,314

Dyp-type peroxidase

Dyp_peroxidase

Family

20,957

false

Heme peroxidases were originally divided into two superfamilies, namely, the animal peroxidases and the plant peroxidases (class I, II and III), which include fungal (class II) and bacterial peroxidases. The DyP (for dye decolorizing peroxidase) family constitutes a novel class of heme peroxidase. Because these enzymes...

[ "GO:0004601", "GO:0020037" ]

[ "peroxidase activity", "heme binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PROFILE", "PANTHER", "NCBIFAM" ]

[ "PS51404", "PTHR30521", "TIGR01413" ]

[ "DYP_PEROXIDASE", "", "Dyp_perox_fam" ]

[ 20858, 20603, 19232 ]

3

[ "EC", "EC", "GP", "GP", "METACYC", "REACTOME" ]

[ "1.11.1", "1.11.1.-", "GenProp0810", "GenProp1470", "PWY-5292", "R-HSA-9638482" ]

[ "EC:1.11.1", "EC:1.11.1.-", "GP:GenProp0810", "GP:GenProp1470", "METACYC:PWY-5292", "REACTOME:R-HSA-9638482" ]

6

[ "2d3q", "2gvk", "2hag", "2iiz", "2y4d", "2y4e", "2y4f", "3afv", "3mm1", "3mm2", "3mm3", "3o72", "3qnr", "3qns", "3vec", "3ved", "3vee", "3vef", "3veg", "3vxi", "3vxj", "4au9", "4g2c", "4grc", "4gs1", "4gt2", "4gu7", "4hov", "4uzi", "4w7j", "4w7k", "4w7l"...

173

[ "PUB00047552", "PUB00047708", "PUB00052610", "PUB00061072", "PUB00099956", "PUB00100762" ]

[ "17654545", "17654547", "17928290", "22308037", "21324904", "32971035" ]

[ "Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.", "Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA.", "DyP, a unique dye-decolorizing peroxidase, represents a novel heme perox...

[ 2007, 2007, 2007, 2012, 2011, 2020 ]

6

[]

[ "IPR006313" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Pandoravirus", "unclassified sequences" ]

[ 81, 18719, 2091, 9, 57 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2, 1 ]

2

true

Family

Dyp-type peroxidase

Dyp_peroxidase

2

IPR006315

6,315

Outer membrane autotransporter barrel domain

OM_autotransptr_brl_dom

Domain

28,758

false

The secretion of protein products occurs by a number of different pathways in bacteria and several secretion mechanisms have been described for Gram-negative bacteria [ ], an increasing number employ a highly efficient but simple mechanism first described for the immunoglobulin A1 (IgA1) proteases [ , ].

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "NCBIFAM" ]

[ "TIGR01414" ]

[ "autotrans_barl" ]

[ 28758 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1074", "R-HSA-202733", "R-HSA-9760173", "R-HSA-9927020" ]

[ "GP:GenProp1074", "REACTOME:R-HSA-202733", "REACTOME:R-HSA-9760173", "REACTOME:R-HSA-9927020" ]

4

[ "1dab", "2iou", "2maf", "2mlh", "2qom", "3aeh", "3ml3", "3qq2", "3slj", "3slo", "3slt", "3syj", "4mee", "5ke1", "7akv", "7ri4", "7rj5", "7tsz", "7tt0", "7tt1", "7tt2", "7tt3", "7tt4", "7tt5", "7tt6", "7tt7", "7ttc", "7ye4", "7ye6", "8bnz", "8bo2", "8q0g"...

40

[ "PUB00008434", "PUB00008435", "PUB00019184", "PUB00033379", "PUB00033380", "PUB00033382" ]

[ "3027577", "9778731", "11980709", "11459823", "8709857", "11179284" ]

[ "Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease.", "The great escape: structure and function of the autotransporter proteins.", "Export of autotransported proteins proceeds through an oligomeric ring shaped by C-terminal domains.", "Protein secretion and the pathogenesis of b...

[ 1987, 1998, 2002, 2001, 1995, 2001 ]

6

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 28549, 13, 89, 107 ]

4

[ "Escherichia coli (strain K12)" ]

[ 10 ]

1

true

Domain

Outer membrane autotransporter barrel domain

OM_autotransptr_brl_dom

1

IPR006316

6,316

Tryptophan synthase, beta chain-like

Trp_synth_b-like

Family

3,982

false

These sequences represent a family of pyridoxal-phosphate dependent enzymes that are closely related to the beta subunit of tryptophan synthase.

[ "GO:0004834", "GO:0030170", "GO:0000162" ]

[ "tryptophan synthase activity", "pyridoxal phosphate binding", "L-tryptophan biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF500824", "TIGR01415" ]

[ "TrpB_prok", "trpB_rel" ]

[ 3967, 3954 ]

2

[ "EC", "GP", "GP" ]

[ "4.2.1.20", "GenProp0037", "GenProp1450" ]

[ "EC:4.2.1.20", "GP:GenProp0037", "GP:GenProp1450" ]

3

[ "4qys", "6hte", "6hul" ]

3

[]

0

[ "IPR023026" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 455, 2890, 533, 104 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 5, 2 ]

3

true

Family

Tryptophan synthase, beta chain-like

Trp_synth_b-like

9

IPR006317

6,317

Ubiquinol-cytochrome c reductase, iron-sulphur subunit

Ubiquinol_cyt_c_Rdtase_Fe-S-su

Domain

13,537

false

These sequences represent the Proteobacterial and mitochondrial type of the Rieske [2Fe-2S] iron-sulphur subunit as found in ubiquinol-cytochrome c reductase. Not included in this group are the Rieske iron-sulphur protein as found in the cytochrome b6-f complex of the Cyanobacteria and chloroplasts. Most members of thi...

[ "GO:0008121" ]

[ "quinol-cytochrome-c reductase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01416" ]

[ "Rieske_proteo" ]

[ 13537 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME...

[ "7.1.1.8", "GenProp0613", "PWY-3781", "PWY-6692", "PWY-7279", "R-BTA-611105", "R-BTA-9865881", "R-CEL-9865881", "R-DME-611105", "R-DME-9865881", "R-DRE-9865881", "R-GGA-611105", "R-GGA-9865881", "R-HSA-611105", "R-HSA-9865881", "R-MMU-611105", "R-MMU-9865881", "R-RNO-611105", "R-...

[ "EC:7.1.1.8", "GP:GenProp0613", "METACYC:PWY-3781", "METACYC:PWY-6692", "METACYC:PWY-7279", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-9865881", "REACTOME:R-CEL-9865881", "REACTOME:R-DME-611105", "REACTOME:R-DME-9865881", "REACTOME:R-DRE-9865881", "REACTOME:R-GGA-611105", "REACTOME:R-GGA-98658...

25

[ "1bcc", "1be3", "1bgy", "1ezv", "1kb9", "1kyo", "1l0l", "1l0n", "1ntk", "1ntm", "1ntz", "1nu1", "1p84", "1pp9", "1ppj", "1qcr", "1rie", "1sqb", "1sqp", "1sqq", "1sqv", "1sqx", "1zrt", "2a06", "2bcc", "2fyn", "2fyu", "2ibz", "2nuk", "2num", "2nve", "2nvf"...

214

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7813, 5566, 158 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 1, 1, 4, 1, 1, 6, 3, 1, 1, 13 ]

12

true

Domain

Ubiquinol-cytochrome c reductase, iron-sulphur subunit

Ubiquinol_cyt_c_Rdtase_Fe-S-su

8

IPR006318

6,318

Phosphotransferase system, enzyme I-like

PTS_EI-like

Domain

27,857

false

Most proteins with this domain are known or deduced to function as the phosphoenolpyruvate-protein phosphotransferases (or enzyme I) of PTS sugar transport systems. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). This domain is also found in enzyme I-Ntr, ...

[ "GO:0016772" ]

[ "transferase activity, transferring phosphorus-containing groups" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01417" ]

[ "PTS_I_fam" ]

[ 27857 ]

1

[ "EC", "GP" ]

[ "2.7.3.9", "GenProp0119" ]

[ "EC:2.7.3.9", "GP:GenProp0119" ]

2

[ "1eza", "1ezb", "1ezc", "1ezd", "1zym", "2bg5", "2eza", "2ezb", "2ezc", "2hro", "2hwg", "2kx9", "2l5h", "2mp0", "2n5t", "2wqd", "2xdf", "2xz7", "2xz9", "3ezb", "3eze", "6v9k", "6vbj", "6vu0" ]

24

[ "PUB00070136", "PUB00076910" ]

[ "18421563", "7496537" ]

[ "Solution structure of NPr, a bacterial signal-transducing protein that controls the phosphorylation state of the potassium transporter-regulating protein IIA Ntr.", "Fructose phosphotransferase system of Xanthomonas campestris pv. campestris: characterization of the fruB gene." ]

[ 2008, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 192, 27451, 26, 188 ]

4

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Domain

Phosphotransferase system, enzyme I-like

PTS_EI-like

7

IPR006321

6,321

Pilus retraction protein PilT/PilU

PilT/PilU

Family

20,068

false

Bacterial type IV pili are critical surface appendages involved in diverse biological processes including horizontal gene transfer, surface and host cell adhesion, biofilm formation, colonization, twitching and virulence. These pili extend and retract from the cell surface, requiring the action of an extension ATPase, ...

[ "GO:0005524" ]

[ "ATP binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "CDD" ]

[ "TIGR01420", "cd01131" ]

[ "pilT_fam", "PilT" ]

[ 19885, 19925 ]

2

[]

0

[ "2ewv", "2eww", "2eyu", "2gsz", "3jvu", "3jvv", "5fl3", "5zfq", "6ojx", "6ojy", "6ojz", "6ok2", "6okv", "6olk", "6oll", "6olm" ]

16

[ "PUB00007956", "PUB00094573", "PUB00094574" ]

[ "10993081", "31626631", "26809217" ]

[ "Pilus retraction powers bacterial twitching motility.", "PilT and PilU are homohexameric ATPases that coordinate to retract type IVa pili.", "The pilT gene contributes to type III ExoS effector injection into epithelial cells in Pseudomonas aeruginosa." ]

[ 2000, 2019, 2016 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 19645, 20, 403 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Pilus retraction protein PilT/PilU

PilT/PilU

1

IPR006322

6,322

Glutathione reductase, eukaryote/bacterial

Glutathione_Rdtase_euk/bac

Family

7,017

false

This entry represents glutathione reductase (GSHR or GRase) from bacteria, animals and fungi. This protein family is one of two closely related subfamilies of GRase, which are also closely related to trypanothione reductase. GRase regenerates glutathione disulphide and NADPH from oxidized glutathione and NADP. In mice,...

[ "GO:0004362", "GO:0050660", "GO:0050661", "GO:0006749" ]

[ "glutathione-disulfide reductase (NADPH) activity", "flavin adenine dinucleotide binding", "NADP binding", "glutathione metabolic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "NCBIFAM" ]

[ "TIGR01421" ]

[ "gluta_reduc_1" ]

[ 7017 ]

1

[ "EC", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTO...

[ "1.8.1.7", "GenProp1721", "PWY-4081", "R-CEL-3299685", "R-CEL-499943", "R-CEL-5628897", "R-DDI-3299685", "R-DDI-499943", "R-DDI-5628897", "R-HSA-2408550", "R-HSA-3299685", "R-HSA-499943", "R-HSA-5628897", "R-HSA-9818027", "R-MMU-3299685", "R-MMU-499943", "R-MMU-5628897", "R-RNO-329...

[ "EC:1.8.1.7", "GP:GenProp1721", "METACYC:PWY-4081", "REACTOME:R-CEL-3299685", "REACTOME:R-CEL-499943", "REACTOME:R-CEL-5628897", "REACTOME:R-DDI-3299685", "REACTOME:R-DDI-499943", "REACTOME:R-DDI-5628897", "REACTOME:R-HSA-2408550", "REACTOME:R-HSA-3299685", "REACTOME:R-HSA-499943", "REACTOME...

26

[ "1bwc", "1dnc", "1ger", "1ges", "1get", "1geu", "1gra", "1grb", "1gre", "1grf", "1grg", "1grh", "1grt", "1gsn", "1k4q", "1xan", "2aaq", "2gh5", "2grt", "2hqm", "2r9z", "2rab", "3djg", "3djj", "3dk4", "3dk8", "3dk9", "3grs", "3grt", "3sqp", "4gr1", "4grt"...

39

[ "PUB00099976", "PUB00099977" ]

[ "29105080", "23623936" ]

[ "Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis.", "Glutathione reductase is essential for host defense against bacterial infection." ]

[ 2018, 2013 ]

2

[ "IPR046952" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Siphoviridae sp. cti6f5", "unclassified sequences" ]

[ 3929, 3053, 1, 34 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe ...

[ 1, 3, 1, 2, 7, 1, 4, 1, 1 ]

9

true

Family

Glutathione reductase, eukaryote/bacterial

Glutathione_Rdtase_euk/bac

2

IPR006323

6,323

Phosphonoacetaldehyde hydrolase

Phosphonoacetald_hydro

Family

3,998

false

Phosphonoacetaldehyde hydrolase or phosphonatase catalyses the cleavage of the carbon-phosphorous bond of a phosphonate. This enzyme is a member of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases, and contains a modified version of the conserved catalytic motifs of that superfamily [ ]. ...

[ "GO:0050194", "GO:0019700" ]

[ "phosphonoacetaldehyde hydrolase activity", "organic phosphonate catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_01375", "TIGR01422", "cd02586" ]

[ "PhnX", "phosphonatase", "HAD_PHN" ]

[ 3993, 3891, 2536 ]

3

[ "EC", "GP", "METACYC" ]

[ "3.11.1.1", "GenProp0238", "PWY-8465" ]

[ "EC:3.11.1.1", "GP:GenProp0238", "METACYC:PWY-8465" ]

3

[ "1fez", "1rdf", "1rql", "1rqn", "1swv", "1sww", "2iof", "2ioh", "3iru" ]

9

[ "PUB00003337", "PUB00009540" ]

[ "7966317", "10956028" ]

[ "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.", "The crystal structure of bacillus cereus phosphonoacetaldehyde hydrolase: insight into catalysis of phosphorus bond cleavage and ca...

[ 1994, 2000 ]

2

[ "IPR006439" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Yasminevirus sp. GU-2018", "unclassified sequences" ]

[ 3781, 188, 1, 28 ]

4

[]

0

true

Family

Phosphonoacetaldehyde hydrolase

Phosphonoacetald_hydro

1

IPR006324

6,324

Glutathione reductase

GSHR

Family

4,398

false

This entry represents glutathione reductase (GSHR or GRase) from proteobacteria, cyanobacteria and plants. This protein family is one of two closely related subfamilies of GRase, both also closely related to trypanothione reductase. GRase regenerates glutathione disulphide and NADPH from oxidized glutathione and NADP. ...

[ "GO:0004362", "GO:0050660", "GO:0050661", "GO:0006749" ]

[ "glutathione-disulfide reductase (NADPH) activity", "flavin adenine dinucleotide binding", "NADP binding", "glutathione metabolic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "NCBIFAM" ]

[ "TIGR01424" ]

[ "gluta_reduc_2" ]

[ 4398 ]

1

[ "EC", "METACYC" ]

[ "1.8.1.7", "PWY-4081" ]

[ "EC:1.8.1.7", "METACYC:PWY-4081" ]

2

[ "3o0h", "4dna" ]

2

[ "PUB00099971", "PUB00099972", "PUB00099974", "PUB00099975" ]

[ "29150514", "23792825", "32365245", "31782847" ]

[ "Sinorhizobium meliloti Glutathione Reductase Is Required for both Redox Homeostasis and Symbiosis.", "Glutathione and glutathione reductase: a boon in disguise for plant abiotic stress defense operations.", "Chloroplasts require glutathione reductase to balance reactive oxygen species and maintain efficient ph...

[ 2018, 2013, 2020, 2020 ]

4

[ "IPR046952" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3244, 1139, 15 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 3, 5 ]

3

true

Family

Glutathione reductase

GSHR

6

IPR006325

6,325

Signal recognition particle, SRP54 subunit, eukaryotic

SRP54_euk

Family

4,657

false

The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, or to the plasma membrane in prokaryotes [ , , ]. SRP recognises the signal sequence of the nascent po...

[ "GO:0003924", "GO:0005525", "GO:0008312", "GO:0006614", "GO:0048500" ]

[ "GTPase activity", "GTP binding", "7S RNA binding", "SRP-dependent cotranslational protein targeting to membrane", "signal recognition particle" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "NCBIFAM" ]

[ "TIGR01425" ]

[ "SRP54_euk" ]

[ 4657 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.5.4", "R-BTA-1799339", "R-CFA-1799339", "R-DDI-1799339", "R-DRE-1799339", "R-HSA-1799339", "R-MMU-1799339", "R-RNO-1799339", "R-SCE-1799339", "R-SPO-1799339" ]

[ "EC:3.6.5.4", "REACTOME:R-BTA-1799339", "REACTOME:R-CFA-1799339", "REACTOME:R-DDI-1799339", "REACTOME:R-DRE-1799339", "REACTOME:R-HSA-1799339", "REACTOME:R-MMU-1799339", "REACTOME:R-RNO-1799339", "REACTOME:R-SCE-1799339", "REACTOME:R-SPO-1799339" ]

10

[ "2j37", "3jaj", "3jan", "4ue5", "5l3q", "6frk", "6r6g", "6y2z", "6y30", "6y32", "7nfx", "7obq", "7obr", "7qwq" ]

14

[ "PUB00028143", "PUB00035998", "PUB00035999", "PUB00053948", "PUB00063486", "PUB00100261", "PUB00103630", "PUB00103631" ]

[ "16469117", "17622352", "17507650", "12364595", "12605305", "34020957", "28972538", "29914977" ]

[ "Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages.", "X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates.", "The signal recognition particle (SRP) RNA links conformational changes in the SRP to pro...

[ 2006, 2007, 2007, 2002, 2003, 2021, 2017, 2018 ]

8

[ "IPR022941" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4657 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 1, 1, 2, 7, 4, 1, 4, 2, 1, 1, 15 ]

12

true

Family

Signal recognition particle, SRP54 subunit, eukaryotic

SRP54_euk

9

IPR006326

6,326

UDP-glycosyltransferase, MGT-like

UDPGT_MGT-like

Family

4,019

false

This entry includes sequences that belong to the UDP-glucuronosyltransferase family such as Macrolide glycosyltransferase from Streptomyces lividans (MGT), a glucosyl transferase for macrolide antibiotic inactivation, and Demethyllactenocin mycarosyltransferase from Streptomyces fradiae, a transferase of glucose-relate...

[ "GO:0016758" ]

[ "hexosyltransferase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01426" ]

[ "MGT" ]

[ 4019 ]

1

[]

0

[ "2iya", "2iyf", "3ia7", "3iaa", "3rsc", "4m60", "4m7p", "4m83", "5du2", "6j31", "6j32", "6kqw", "6kqx", "7bov", "7vlb", "7vm0", "7xx4", "8h5d" ]

18

[ "PUB00001835", "PUB00100296", "PUB00100297", "PUB00100298" ]

[ "8244027", "33152360", "10658660", "28315700" ]

[ "Characterization of a Streptomyces antibioticus gene cluster encoding a glycosyltransferase involved in oleandomycin inactivation.", "Structural and biochemical studies of the glycosyltransferase Bs-YjiC from Bacillus subtilis.", "The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.", ...

[ 1993, 2021, 2000, 2017 ]

4

[ "IPR002213" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 4010, 7, 2 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

UDP-glycosyltransferase, MGT-like

UDPGT_MGT-like

2

IPR006327

6,327

Phosphotransferase system, fructose IIC component

PTS_IIC_fruc

Domain

17,297

false

This entry represents the IIC component, or IIC region of a IIABC or IIBC polypeptide of a phosphotransferase system for carbohydrate transport. Members of this family belong to the fructose-specific subfamily of the broader family of PTS EIIC proteins. Members should be found as part of the same chain or in the same o...

[ "GO:0005351", "GO:0008982", "GO:0009401", "GO:0016020" ]

[ "carbohydrate:proton symporter activity", "protein-N(PI)-phosphohistidine-sugar phosphotransferase activity", "phosphoenolpyruvate-dependent sugar phosphotransferase system", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR01427" ]

[ "PTS_IIC_fructo" ]

[ 17297 ]

1

[ "EC", "GP", "GP" ]

[ "2.7.1.202", "GenProp0119", "GenProp0693" ]

[ "EC:2.7.1.202", "GP:GenProp0119", "GP:GenProp0693" ]

3

[]

0

[ "PUB00060540" ]

[ "22493022" ]

[ "Fructose degradation in the haloarchaeon Haloferax volcanii involves a bacterial type phosphoenolpyruvate-dependent phosphotransferase system, fructose-1-phosphate kinase, and class II fructose-1,6-bisphosphate aldolase." ]

[ 2012 ]

1

[ "IPR013014" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 17141, 7, 117, 32 ]

4

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Domain

Phosphotransferase system, fructose IIC component

PTS_IIC_fruc

9

IPR006328

6,328

L-2-Haloacid dehalogenase

2-HAD

Family

12,243

false

These proteins catalyse the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids [ ]. They belong to the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases, class (subfamily) I. Note that the Type I HAD enzymes have not yet been fully ch...

[ "GO:0019120" ]

[ "hydrolase activity, acting on halide bonds, in C-halide compounds" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "CDD" ]

[ "TIGR01428", "cd02588" ]

[ "HAD_type_II", "HAD_L2-DEX" ]

[ 12040, 7553 ]

2

[ "EC", "METACYC" ]

[ "3.8.1.2", "PWY-7425" ]

[ "EC:3.8.1.2", "METACYC:PWY-7425" ]

2

[ "1aq6", "1jud", "1qh9", "1qq5", "1qq6", "1qq7", "1zrm", "1zrn", "2no4", "2no5", "2w11", "2w43", "2yml", "2ymm", "2ymp", "2ymq", "2yn4", "3smv", "3um9", "3umb", "3umc", "3umg", "4ce6", "4cf3", "4cf4", "4cf5", "4cnq", "7arp", "7asz", "7qnm", "8hp5", "8hp6"...

49

[ "PUB00009547" ]

[ "11404103" ]

[ "Microbial dehalogenation." ]

[ 2001 ]

1

[ "IPR006439" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 345, 9738, 2048, 112 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

L-2-Haloacid dehalogenase

2-HAD

2

IPR006329

6,329

AMP deaminase

AMPD

Family

13,083

false

AMP-deaminase (AMPD) ( ) is a large, well-conserved eukaryotic protein that catalyses the hydrolytic deamination of adenosine monophosphate (AMP) to inosine monophosphate (IMP), and so plays an important role in purine and energy metabolism [ , ]. This entry also includes inactive deaminases from yeast, which lack the ...

[ "GO:0003876", "GO:0032264" ]

[ "AMP deaminase activity", "IMP salvage" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM", "CDD" ]

[ "PF19326", "PIRSF001251", "PTHR11359", "TIGR01429", "cd01319" ]

[ "AMP_deaminase", "AMP_deaminase_met", "", "AMP_deaminase", "AMPD" ]

[ 13078, 7257, 12706, 9926, 9103 ]

5

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.4.6", "PWY-6596", "R-DDI-6798695", "R-DDI-74217", "R-HSA-6798695", "R-HSA-74217", "R-MMU-6798695", "R-MMU-74217", "R-RNO-6798695", "R-RNO-74217", "R-SCE-6798695", "R-SCE-74217", "R-SPO-6798695", "R-SPO-74217" ]

[ "EC:3.5.4.6", "METACYC:PWY-6596", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-74217", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-74217", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-74217", "REACTOME:R-RNO-6798695", "REACTOME:R-RNO-74217", "REACTOME:R-SCE-6798695", "REACTOME:R-SCE-74217", "REACTOM...

14

[ "2a3l", "8hu6", "8hub" ]

3

[ "PUB00070718", "PUB00154422" ]

[ "23911318", "9291127" ]

[ "AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder.", "Regulation of rat AMP deaminase 3 (isoform C) by development and skeletal muscle fibre type." ]

[ 2013, 1997 ]

2

[]

0

null

[ "Eukaryota", "Pantoea vagans", "mine drainage metagenome" ]

[ 13079, 3, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 4, 33, 10, 28, 9, 1, 3, 19, 3, 1, 14 ]

12

true

Family

AMP deaminase

AMPD

7

IPR006331

6,331

Adenosine deaminase-related growth factor

ADGF

Family

2,329

false

Members of this family have been described as secreted proteins with growth factor activity and regions of adenosine deaminase homology in insects, molluscs, and vertebrates [ ]. Adenosine deaminase-related growth factors (ADGF) are also known as CECR1 in vertebrates. They are a novel family of growth factors with sequ...

[ "GO:0004000", "GO:0006154", "GO:0005615" ]

[ "adenosine deaminase activity", "adenosine catabolic process", "extracellular space" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01431" ]

[ "adm_rel" ]

[ 2329 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.4.4", "PWY-6609", "PWY-6611", "PWY-7179", "R-DDI-5683826", "R-DDI-6798695", "R-DRE-5683826", "R-DRE-6798695", "R-HSA-5683826", "R-HSA-6798695" ]

[ "EC:3.5.4.4", "METACYC:PWY-6609", "METACYC:PWY-6611", "METACYC:PWY-7179", "REACTOME:R-DDI-5683826", "REACTOME:R-DDI-6798695", "REACTOME:R-DRE-5683826", "REACTOME:R-DRE-6798695", "REACTOME:R-HSA-5683826", "REACTOME:R-HSA-6798695" ]

10

[ "3lgd", "3lgg", "9nte", "9ntf", "9ntg", "9nth", "9nti", "9ntj", "9ntk" ]

9

[ "PUB00009548", "PUB00043445", "PUB00043446", "PUB00043447", "PUB00043448" ]

[ "10903440", "18032387", "17439545", "15579078", "15907156" ]

[ "A family of genes with growth factor and adenosine deaminase similarity are preferentially expressed in the salivary glands of Glossina m. morsitans.", "The extracellular adenosine deaminase growth factor, ADGF/CECR1, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor.", "Molecular characteriz...

[ 2000, 2008, 2007, 2004, 2005 ]

5

[ "IPR006330" ]

[]

1

0

1

[ "Bacteroidota", "Eukaryota" ]

[ 46, 2283 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens" ]

[ 4, 12, 12 ]

3

true

Family

Adenosine deaminase-related growth factor

ADGF

5

IPR006332

6,332

Quinol oxidase subunit II

QoxA

Family

1,390

false

Members of this family catalyze the oxidation of quinol with the concomitant reduction of molecular oxygen to water. This acts as the terminal electron acceptor in the respiratory chain. This subunit contains two transmembrane helices and a large external domain responsible for the binding and oxidation of quinol. QuoX...

[ "GO:0009486", "GO:0016682", "GO:0016020" ]

[ "cytochrome bo3 ubiquinol oxidase activity", "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor", "membrane" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01432" ]

[ "QOXA" ]

[ 1390 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.10.3.-", "GenProp0620", "PWY-5399", "PWY-5404", "PWY-5439", "PWY-5476", "PWY-5780", "PWY-5787", "PWY-7079" ]

[ "EC:1.10.3.-", "GP:GenProp0620", "METACYC:PWY-5399", "METACYC:PWY-5404", "METACYC:PWY-5439", "METACYC:PWY-5476", "METACYC:PWY-5780", "METACYC:PWY-5787", "METACYC:PWY-7079" ]

9

[ "6kob", "6koc", "6koe" ]

3

[ "PUB00006601" ]

[ "1316894" ]

[ "Molecular cloning, sequencing, and physiological characterization of the qox operon from Bacillus subtilis encoding the aa3-600 quinol oxidase." ]

[ 1992 ]

1

[ "IPR045187" ]

[]

1

0

1

[ "Bacteria", "human gut metagenome" ]

[ 1389, 1 ]

2

[]

0

true

Family

Quinol oxidase subunit II

QoxA

1

IPR006333

6,333

Cytochrome o ubiquinol oxidase subunit II

Cyt_o_ubiquinol_oxidase_su2

Family

7,659

false

This enzyme catalyses the oxidation of ubiquinol with the concomitant reduction of molecular oxygen to water. This acts as the terminal electron acceptor in the respiratory chain. Subunit II is responsible for binding and oxidation of the ubiquinone substrate. This sequence is closely related to QoxA, which oxidizes qu...

[ "GO:0016682", "GO:0016020" ]

[ "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF000292", "TIGR01433" ]

[ "Ubi_od_II", "CyoA" ]

[ 6740, 6449 ]

2

[ "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP" ]

[ "GenProp0618", "GenProp1164", "GenProp1256", "GenProp1367", "GenProp1401", "GenProp1493", "GenProp1563", "GenProp1641", "GenProp1751" ]

[ "GP:GenProp0618", "GP:GenProp1164", "GP:GenProp1256", "GP:GenProp1367", "GP:GenProp1401", "GP:GenProp1493", "GP:GenProp1563", "GP:GenProp1641", "GP:GenProp1751" ]

9

[ "1fft", "6kob", "6koc", "6koe", "6wti", "7cub", "7cuq", "7cuw", "7n9z", "7xmc", "7xmd", "8f68", "8f6c", "8go3", "8qqk" ]

15

[ "PUB00006602" ]

[ "2162835" ]

[ "The sequence of the cyo operon indicates substantial structural similarities between the cytochrome o ubiquinol oxidase of Escherichia coli and the aa3-type family of cytochrome c oxidases." ]

[ 1990 ]

1

[ "IPR045187" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7638, 7, 14 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cytochrome o ubiquinol oxidase subunit II

Cyt_o_ubiquinol_oxidase_su2

4

IPR006334

6,334

Glutamate--cysteine ligase, monofunctional

Glut_cys_ligase

Family

7,793

false

These sequences represent glutamate--cysteine ligase, also known as gamma-glutamylcysteine synthetase, an enzyme in the biosynthesis of glutathione (GSH). GSH is one of several low molecular weight cysteine derivatives that can serve to protect against oxidative damage and participate in biosynthetic or detoxification ...

[ "GO:0004357", "GO:0006750" ]

[ "glutamate-cysteine ligase activity", "glutathione biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_00578", "PTHR38761", "TIGR01434" ]

[ "Glu_cys_ligase", "", "glu_cys_ligase" ]

[ 5614, 7793, 5608 ]

3

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC" ]

[ "6.3.2.2", "GenProp0030", "GenProp1359", "PWY-6840", "PWY-7255", "PWY-8043" ]

[ "EC:6.3.2.2", "GP:GenProp0030", "GP:GenProp1359", "METACYC:PWY-6840", "METACYC:PWY-7255", "METACYC:PWY-8043" ]

6

[ "1v4g", "1va6", "2d32", "2d33", "3ln6", "3ln7", "3nzt" ]

7

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriaceae", "unclassified sequences" ]

[ 7664, 6, 21, 102 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glutamate--cysteine ligase, monofunctional

Glut_cys_ligase

1

IPR006336

6,336

Glutamate--cysteine ligase, GCS2

GCS2

Family

27,079

false

Also known as gamma-glutamylcysteine synthetase and gamma-ECS ( ). This enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis. Members of this family are found in archaea, bacteria and plants. May and Leaver [ ] discuss the possible evolutionary origins of glutamate-cysteine ligase enzym...

[ "GO:0004357", "GO:0042398" ]

[ "glutamate-cysteine ligase activity", "modified amino acid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF04107" ]

[ "GCS2" ]

[ 27079 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC" ]

[ "6.3.2.2", "GenProp1359", "PWY-6840", "PWY-7255", "PWY-8043" ]

[ "EC:6.3.2.2", "GP:GenProp1359", "METACYC:PWY-6840", "METACYC:PWY-7255", "METACYC:PWY-8043" ]

5

[ "1r8g", "1tt4", "2gwc", "2gwd", "6gmo" ]

5

[ "PUB00014837" ]

[ "7937837" ]

[ "Arabidopsis thaliana gamma-glutamylcysteine synthetase is structurally unrelated to mammalian, yeast, and Escherichia coli homologs." ]

[ 1994 ]

1

[]

[ "IPR011792", "IPR011793", "IPR035434" ]

0

3

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1062, 24564, 1250, 203 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 5, 14 ]

4

true

Family

Glutamate--cysteine ligase, GCS2

GCS2

2

IPR006337

6,337

D-glucosaminate-6-phosphate ammonia lyase DgaE-like

DgaE-like

Family

2,871

false

DgaE catalyses the conversion of D-glucosaminate 6-phosphate to yield keto-3-deoxygluconate 6-phosphate (KDGP) [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR01437" ]

[ "selA_rel" ]

[ 2871 ]

1

[ "GP" ]

[ "GenProp0798" ]

[ "GP:GenProp0798" ]

1

[ "7lc0", "7lce" ]

2

[ "PUB00075650" ]

[ "23836865" ]

[ "Salmonella utilizes D-glucosaminate via a mannose family phosphotransferase system permease and associated enzymes." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 2868, 2, 1 ]

3

[]

0

true

Family

D-glucosaminate-6-phosphate ammonia lyase DgaE-like

DgaE-like

2

IPR006338

6,338

Thioredoxin/glutathione reductase selenoprotein

Thioredoxin/glutathione_Rdtase

Family

4,903

false

This entry represents thioredoxin reductase family, including thioredoxin reductase 1 and 2 from animals. This homodimeric, FAD-containing member of the pyridine nucleotide disulphide oxidoreductase family contains a C-terminal motif Cys-SeCys-Gly, where SeCys is selenocysteine encoded by TGA (in some sequence reports ...

[ "GO:0004791" ]

[ "thioredoxin-disulfide reductase (NADPH) activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01438" ]

[ "TGR" ]

[ 4903 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "1.8.1.9", "R-BTA-3299685", "R-BTA-499943", "R-BTA-5263617", "R-BTA-5628897", "R-CEL-3299685", "R-CEL-499943", "R-CEL-5263617", "R-CEL-5628897", "R-DME-3299685", "R-HSA-1989781", "R-HSA-2408550", "R-HSA-3299685", "R-HSA-499943", "R-HSA-5263617", "R-HSA-5336415", "R-HSA-5628897", "R...

[ "EC:1.8.1.9", "REACTOME:R-BTA-3299685", "REACTOME:R-BTA-499943", "REACTOME:R-BTA-5263617", "REACTOME:R-BTA-5628897", "REACTOME:R-CEL-3299685", "REACTOME:R-CEL-499943", "REACTOME:R-CEL-5263617", "REACTOME:R-CEL-5628897", "REACTOME:R-DME-3299685", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-240855...

30

[ "1h6v", "1zdl", "1zkq", "2cfy", "2j3n", "2nvk", "2v6o", "2x8c", "2x8g", "2x8h", "2x99", "2zz0", "2zzb", "2zzc", "3dgh", "3dgz", "3dh9", "3ean", "3eao", "3h4k", "3qfa", "3qfb", "4b1b", "4j56", "4j57", "4kpr", "4la1", "5w1j", "5w1l", "6fmu", "6fmz", "6fp4"...

86

[ "PUB00009581", "PUB00009582" ]

[ "11259642", "8650234" ]

[ "Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems.", "Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene." ]

[ 2001, 1996 ]

2

[ "IPR046952" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4903 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 3, 19, 11, 10 ]

6

true

Family

Thioredoxin/glutathione reductase selenoprotein

Thioredoxin/glutathione_Rdtase

3

IPR006340

6,340

Protein of unknown function DUF436

DUF436

Family

3,364

false

Members of this family are uncharacterised proteins predominantly found in Firmicutes in no more than one copy per genome.

[]

0

[ "HAMAP", "PFAM", "PIRSF", "NCBIFAM" ]

[ "MF_00800", "PF04260", "PIRSF007510", "TIGR01440" ]

[ "UPF0340", "DUF436", "UCP007510", "" ]

[ 3342, 3364, 3209, 3337 ]

4

[]

0

[ "1v8d", "7z06" ]

2

[]

0

[]

0

null

[ "Acyrthosiphon pisum", "Bacteria", "metagenomes" ]

[ 1, 3347, 16 ]

3

[]

0

true

Family

Protein of unknown function DUF436

DUF436

3

IPR006341

6,341

Acid-soluble spore protein, gamma-type

Spore_gamma

Family

1,224

false

This is a family of small, glutamine and asparagine-rich peptides that store amino acids in the spores of Bacillus subtilis and related bacteria. Most members of the family have two copies of the spore protease (GPR) cleavage motif, typically EFASE in this family, separating three low-complexity repeats.

[ "GO:0030435" ]

[ "sporulation resulting in formation of a cellular spore" ]

[ "biological_process" ]

1

[ "PFAM", "NCBIFAM" ]

[ "PF04259", "TIGR01442" ]

[ "SASP_gamma", "SASP_gamma" ]

[ 1172, 1184 ]

2

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[]

0

[]

0

null

[ "Bacilli" ]

[ 1224 ]

1

[]

0

true

Family

Acid-soluble spore protein, gamma-type

Spore_gamma

5

IPR006342

6,342

Methyltransferase FkbM

FkbM_mtfrase

Domain

29,758

false

This domain is characterised by two well-conserved short regions separated by a variable region in both sequence and length. The first of the two regions is found in a large number of proteins outside this group, a number of which have been characterised as methyltransferases. One member of this group, FkbM, was shown ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF05050", "TIGR01444" ]

[ "Methyltransf_21", "fkbM_fam" ]

[ 28672, 23948 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[ "2py6" ]

1

[ "PUB00009583", "PUB00089798", "PUB00100396", "PUB00100397" ]

[ "8752344", "27072286", "20543073", "25814981" ]

[ "Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.", "Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase.",...

[ 1996, 2016, 2010, 2015 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 819, 20078, 7656, 148, 1057 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Drosophila melanogaster", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 45, 2, 2, 7 ]

5

true

Domain

Methyltransferase FkbM

FkbM_mtfrase

5

IPR006343

6,343

DnaB/C, C-terminal domain

DnaB/C_C

Domain

11,734

false

This entry describes the C-terminal domain in DnaB, DnaD and related bacterial proteins. This domain is α-helical. DnaB is a key component of the bacterial DNA replication machinery, involved in both initiation and replication restart. It functions in coordination with DnaI to assist in loading the replicative helicase...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF07261", "TIGR01446" ]

[ "DnaB_2", "DnaD_dom" ]

[ 11693, 8157 ]

2

[]

0

[ "2i5u", "2zc2", "8ojj" ]

3

[ "PUB00009584", "PUB00085025", "PUB00160774", "PUB00160775", "PUB00160776" ]

[ "11679082", "16677303", "12718886", "15186423", "19968790" ]

[ "DnaB, DnaD and DnaI proteins are components of the Bacillus subtilis replication restart primosome.", "The DNA-remodelling activity of DnaD is the sum of oligomerization and DNA-binding activities on separate domains.", "A two-protein strategy for the functional loading of a cellular replicative DNA helicase."...

[ 2001, 2006, 2003, 2004, 2010 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 11328, 9, 265, 132 ]

4

[]

0

true

Domain

DnaB/C, C-terminal domain

DnaB/C_C

3

IPR006344

6,344

RecBCD enzyme subunit RecD

RecD

Family

7,888

false

Exodeoxyribonuclease V or RecBCD is an heterotrimeric enzyme comprised of the proteins RecB, RecC and RecD. RecBCD is a helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair [ ]. Subunit RecD is a DNA helicase with 5' --> 3' polarity, whereas the RecB subunit possesses a 3' --> 5' DNA helica...

[ "GO:0004386", "GO:0008854", "GO:0006302", "GO:0006310", "GO:0009338" ]

[ "helicase activity", "exodeoxyribonuclease V activity", "double-strand break repair", "DNA recombination", "exodeoxyribonuclease V complex" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]

5

[ "HAMAP", "NCBIFAM" ]

[ "MF_01487", "TIGR01447" ]

[ "RecD", "recD" ]

[ 7741, 7559 ]

2

[ "EC", "GP", "GP" ]

[ "5.6.2.3", "GenProp0216", "GenProp1188" ]

[ "EC:5.6.2.3", "GP:GenProp0216", "GP:GenProp1188" ]

3

[ "1w36", "3k70", "5ld2", "5mbv", "6sjb", "6sje", "6sjf", "6sjg", "6t2u", "6t2v", "7mr0", "7mr1", "7mr2", "7mr3", "7mr4", "8b1r", "8b1t", "8b1u" ]

18

[ "PUB00074177", "PUB00074178", "PUB00074179" ]

[ "12815438", "9230304", "16041061" ]

[ "RecBCD enzyme is a bipolar DNA helicase.", "The translocating RecBCD enzyme stimulates recombination by directing RecA protein onto ssDNA in a chi-regulated manner.", "Bipolar DNA translocation contributes to highly processive DNA unwinding by RecBCD enzyme." ]

[ 2003, 1997, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7813, 7, 68 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RecBCD enzyme subunit RecD

RecD

2

IPR006345

6,345

ATP-dependent RecD2 DNA helicase

RecD2

Family

8,317

false

These sequences represent a family similar to RecD from the RecBCD enzyme . Members of this family, however, are not found in a context of RecB and RecC and are longer by about 200 amino acids at the amino end. In Deinococcus radiodurans RecD2 is a DNA helicase with 5'-3' polarity and low processivity [ ]. Chlamydia mu...

[ "GO:0003677", "GO:0043139", "GO:0006310" ]

[ "DNA binding", "5'-3' DNA helicase activity", "DNA recombination" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01488", "TIGR01448" ]

[ "RecD2", "helicase_RecD2" ]

[ 7944, 8307 ]

2

[]

0

[]

0

[ "PUB00074180" ]

[ "15466873" ]

[ "DNA helicase activity of the RecD protein from Deinococcus radiodurans." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8256, 21, 40 ]

3

[]

0

true

Family

ATP-dependent RecD2 DNA helicase

RecD2

1

IPR006349

6,349

2-phosphoglycolate phosphatase, eukaryotic

PGP_euk

Family

5,134

false

This family of sequences represent 2-phosphoglycolate phosphatase which is limited to the eukaryotic lineage. PGP is an essential enzyme in the glycolate salvage pathway in higher organisms (photorespiration in plants). Phosphoglycolate results from the oxidase activity of RubisCO in the Calvin cycle when concentration...

[ "GO:0016791" ]

[ "phosphatase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01452" ]

[ "PGP_euk" ]

[ 5134 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3", "GenProp1747", "R-BTA-1483206", "R-CEL-9013407", "R-HSA-1483206", "R-MMU-1483206", "R-RNO-1483206" ]

[ "EC:3.1.3", "GP:GenProp1747", "REACTOME:R-BTA-1483206", "REACTOME:R-CEL-9013407", "REACTOME:R-HSA-1483206", "REACTOME:R-MMU-1483206", "REACTOME:R-RNO-1483206" ]

7

[ "2cfr", "2cfs", "2cft", "2oyc", "2p27", "2p69", "4bkm", "4bx0", "4bx2", "4bx3", "5aes", "5gyn", "7po7", "7poe", "8qfw", "8s8a", "9em1" ]

17

[ "PUB00009589", "PUB00009590", "PUB00009591", "PUB00009592", "PUB00097892" ]

[ "11601995", "11581250", "3015949", "2164460", "26755581" ]

[ "MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases.", "Characteristics and sequence of phosphoglycolate phosphatase from a eukaryotic green alga Chlamydomonas reinhardtii.", "Mechanism of activation by anions of phosphoglycolate phosphatases from spi...

[ 2001, 2001, 1986, 1990, 2016 ]

5

[ "IPR006357" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Thermococcaceae" ]

[ 7, 5122, 5 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 6, 2, 4, 3, 3, 1, 4, 5, 1, 1, 5 ]

12

true

Family

2-phosphoglycolate phosphatase, eukaryotic

PGP_euk

7

IPR006350

6,350

Intron endonuclease, group I

Intron_endoG1

Family

2,109

false

This entry represents a subfamily of endonucleases containing the N-terminal endo/excinuclease amino terminal domain, . Sequences containing this domain are often termed often termed GIY-YIG endonucleases after a conserved sequence motif. The sequences are encoded by open reading frames found in group I introns in both...

[ "GO:0004519" ]

[ "endonuclease activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01453" ]

[ "grpIintron_endo" ]

[ 2109 ]

1

[]

0

[ "1i3j", "1ln0", "1mk0", "1t2t" ]

4

[ "PUB00017038", "PUB00017039" ]

[ "12379841", "11447104" ]

[ "Catalytic domain structure and hypothesis for function of GIY-YIG intron endonuclease I-TevI.", "Intertwined structure of the DNA-binding domain of intron endonuclease I-TevI with its substrate." ]

[ 2002, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "metagenomes" ]

[ 302, 1333, 5, 367, 102 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Intron endonuclease, group I

Intron_endoG1

2

IPR006351

6,351

3-amino-5-hydroxybenzoic acid synthesis-related

AHBA_synth-like

Family

263

false

The enzymes in this family are all located in the operons for the biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), which is a precursor of several antibiotics including ansatrienin [ ], naphthomycin [ ], rifamycin [ ] and mitomycin [ ]. The role that this enzyme plays in this biosynthesis has not been elucidated. ...

[]

0

[ "NCBIFAM" ]

[ "TIGR01454" ]

[ "AHBA_synth_RP" ]

[ 263 ]

1

[]

0

[]

0

[ "PUB00009593", "PUB00009722", "PUB00009723" ]

[ "10103039", "11278540", "10099135" ]

[ "Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tu 1892.", "Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starte...

[ 1999, 2001, 1999 ]

3

[ "IPR006439" ]

[]

1

0

1

[ "Actinomycetes" ]

[ 263 ]

1

[]

0

true

Family

3-amino-5-hydroxybenzoic acid synthesis-related

AHBA_synth-like

9

IPR006352

6,352

Phosphoglucosamine mutase, bacterial type

GlmM_bact

Family

21,284

false

The alpha-D-phosphohexomutase superfamily is composed of four related enzymes, each of which catalyses a phosphoryl transfer on their sugar substrates: phosphoglucomutase (PGM), phosphoglucomutase/phosphomannomutase (PGM/PMM), phosphoglucosamine mutase (PNGM), and phosphoacetylglucosamine mutase (PAGM) [ ]. PGM ( ) con...

[ "GO:0000287", "GO:0008966", "GO:0005975" ]

[ "magnesium ion binding", "phosphoglucosamine mutase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_01554_B", "TIGR01455", "cd05802" ]

[ "GlmM_B", "glmM", "GlmM" ]

[ 21106, 21230, 21121 ]

3

[ "EC", "GP", "GP", "GP", "METACYC" ]

[ "5.4.2.10", "GenProp0750", "GenProp1443", "GenProp1623", "PWY-6749" ]

[ "EC:5.4.2.10", "GP:GenProp0750", "GP:GenProp1443", "GP:GenProp1623", "METACYC:PWY-6749" ]

5

[ "3i3w", "3pdk", "6gyz", "7ojr", "7ojs", "7olh", "7oml", "9g69" ]

8

[ "PUB00009595", "PUB00009596", "PUB00009597", "PUB00022429", "PUB00037156", "PUB00040705", "PUB00042561", "PUB00042562", "PUB00042563", "PUB00042564", "PUB00080213", "PUB00080214", "PUB00080215", "PUB00080216", "PUB00080217" ]

[ "8550580", "9171391", "9286983", "14725765", "15299905", "16595672", "10506283", "10913078", "11004509", "15238632", "10671448", "10231382", "15720398", "9549096", "12604356" ]

[ "Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli.", "The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase.", "The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphog...

[ 1996, 1997, 1997, 2004, 1997, 2006, 1999, 2000, 2000, 2004, 2000, 1999, 2005, 1998, 2003 ]

15

[ "IPR005841" ]

[]

1

0

1

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "Myoviridae sp. ctWXg38", "unclassified sequences" ]

[ 20907, 6, 20, 1, 350 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phosphoglucosamine mutase, bacterial type

GlmM_bact

4

IPR006353

6,353

HAD-superfamily hydrolase, subfamily IIA, CECR5

HAD-SF_hydro_IIA_CECR5

Family

6,939

false

This family is a member of the Class IIA subfamily of the haloacid dehalogenase superfamily of aspartate-nucleophile hydrolases. Sequences in this family are all from eukaryotes. The human sequence is called "Cat Eye Syndrome critical region protein 5" (CECR5) [ ], also known as Haloacid dehalogenase-like hydrolase dom...

[]

0

[ "NCBIFAM" ]

[ "TIGR01456" ]

[ "CECR5" ]

[ 6939 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-SPO-1482925", "R-SPO-1483076" ]

[ "REACTOME:R-SPO-1482925", "REACTOME:R-SPO-1483076" ]

2

[ "3kc2", "3rf6" ]

2

[ "PUB00015450", "PUB00042821", "PUB00151491" ]

[ "11381032", "14562106", "29958934" ]

[ "Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.", "Global analysis of protein expression in yeast.", "Schizosaccharomyces pombe cardiolipin synthase is part of a mitochondrial...

[ 2001, 2003, 2018 ]

3

[ "IPR006357" ]

[]

1

0

1

[ "Eukaryota" ]

[ 6939 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "S...

[ 7, 2, 1, 2, 1, 4, 3, 3, 1, 1, 7 ]

11

true

Family

HAD-superfamily hydrolase, subfamily IIA, CECR5

HAD-SF_hydro_IIA_CECR5

5

IPR006355

6,355

HAD hydrolase, LHPP/HDHD2

LHPP/HDHD2

Family

3,597

false

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) hydrolyzes nitrogen-phosphorus bonds in phospholysine, phosphohistidine and imidodiphosphate as well as oxygen-phosphorus bonds in inorganic pyrophosphate in vitro [ ]. This family also includes human haloacid dehalogenase like hydrolase domain c...

[ "GO:0016791", "GO:0016311" ]

[ "phosphatase activity", "dephosphorylation" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR01458", "cd07509" ]

[ "HAD-SF-IIA-hyp3", "HAD_PPase" ]

[ 3561, 2125 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-71737", "R-DRE-71737", "R-HSA-71737", "R-MMU-71737", "R-RNO-71737" ]

[ "REACTOME:R-BTA-71737", "REACTOME:R-DRE-71737", "REACTOME:R-HSA-71737", "REACTOME:R-MMU-71737", "REACTOME:R-RNO-71737" ]

5

[ "2ho4", "2x4d", "3hlt" ]

3

[ "PUB00085864", "PUB00085865" ]

[ "12801912", "26103128" ]

[ "Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase.", "Two candidate genes for two quantitative trait loci epistatically attenuate hypertension in a novel pathway." ]

[ 2003, 2015 ]

2

[ "IPR006357" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 694, 2847, 39, 17 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 1, 8, 2, 13 ]

6

true

Family

HAD hydrolase, LHPP/HDHD2

LHPP/HDHD2

7

IPR006356

6,356

HAD-superfamily hydrolase, subfamily IIA, hypothetical 3

HAD-SF_hydro_IIA_hyp3

Family

3,530

false

These sequences are all members of the Class IIA subfamily of the haloacid dehalogenase superfamily of aspartate-nucleophile hydrolases. The sequences are restricted to the Gram-negative and primarily alpha proteobacteria. Only one sequence has been annotated as other than "hypothetical." That one, from Brucella, is an...

[]

0

[ "NCBIFAM" ]

[ "TIGR01459" ]

[ "HAD-SF-IIA-hyp4" ]

[ 3530 ]

1

[]

0

[ "2hx1", "6nq4" ]

2

[]

0

[ "IPR006357" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2878, 621, 31 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 2, 4 ]

3

true

Family

HAD-superfamily hydrolase, subfamily IIA, hypothetical 3

HAD-SF_hydro_IIA_hyp3

3

IPR006358

6,358

Transcription elongation factor GreB

Tscrpt_elong_fac_GreB

Family

6,800

false

Bacterial GreA and GreB promote transcription elongation by stimulating an endogenous, endonucleolytic transcript cleavage activity of the RNA polymerase, allowing RNA transcription to continue past template-encoded arresting sites. GreA and GreB are sequence homologues and have homologues in every known bacterial geno...

[ "GO:0003677", "GO:0032784" ]

[ "DNA binding", "regulation of DNA-templated transcription elongation" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00930", "TIGR01461" ]

[ "GreB", "greB" ]

[ 6775, 6634 ]

2

[]

0

[ "2p4v", "6ri7", "6rin" ]

3

[ "PUB00011909" ]

[ "12914698" ]

[ "Structure and function of the transcription elongation factor GreB bound to bacterial RNA polymerase." ]

[ 2003 ]

1

[ "IPR028624" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6742, 6, 52 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcription elongation factor GreB

Tscrpt_elong_fac_GreB

4

IPR006359

6,359

Transcription elongation factor GreA

Tscrpt_elong_fac_GreA

Family

22,244

false

Bacterial GreA and GreB promote transcription elongation by stimulating an endogenous, endonucleolytic transcript cleavage activity of the RNA polymerase (RNAP) [ ], allowing RNA transcription to continue past template-encoded arresting sites. GreA and GreB are sequence homologues and have homologues in every known bac...

[ "GO:0003677", "GO:0032784" ]

[ "DNA binding", "regulation of DNA-templated transcription elongation" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01462" ]

[ "greA" ]

[ 22244 ]

1

[]

0

[ "1grj" ]

1

[ "PUB00004205", "PUB00011909" ]

[ "7854424", "12914698" ]

[ "Crystal structure of the GreA transcript cleavage factor from Escherichia coli.", "Structure and function of the transcription elongation factor GreB bound to bacterial RNA polymerase." ]

[ 1995, 2003 ]

2

[ "IPR028624" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctHip2", "unclassified sequences" ]

[ 21884, 41, 1, 318 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcription elongation factor GreA

Tscrpt_elong_fac_GreA

4

IPR006360

6,360

Methyltransferase MtaA/CmuA

Mtase_MtaA_CmuA

Domain

707

false

This entry represents a methyltransferase domain found in proteins which are involved in C1 metabolism in methanogenic archaea and methylotrophic bacteria. It is closely related to, yet is distinct from, uroporphyrinogen decarboxylase ( ). In methanogens, this domain is found in single-domain proteins catalysing the tr...

[ "GO:0008168", "GO:0006730" ]

[ "methyltransferase activity", "one-carbon metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR01463", "cd03307" ]

[ "mtaA_cmuA", "Mta_CmuA_like" ]

[ 702, 390 ]

2

[]

0

[ "4ay7", "4ay8" ]

2

[ "PUB00009600", "PUB00015988", "PUB00016918", "PUB00016919", "PUB00016920", "PUB00016938" ]

[ "8654414", "9371433", "10200311", "10447694", "11358510", "8617801" ]

[ "Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli.", "Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri...

[ 1996, 1997, 1999, 1999, 2001, 1996 ]

6

[ "IPR000257" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Geodia barretti", "ecological metagenomes" ]

[ 442, 254, 1, 10 ]

4

[]

0

true

Domain

Methyltransferase MtaA/CmuA

Mtase_MtaA_CmuA

4

IPR006361

6,361

Uroporphyrinogen decarboxylase HemE

Uroporphyrinogen_deCO2ase_HemE

Family

24,864

false

This entry represents uroporphyrinogen decarboxylase (URO-D or HemE), which catalyzes the fifth step in the haem biosynthetic pathway, converting uroporphyrinogen III to coproporphyrinogen III by decarboxylating the four acetate side chains of the substrate [ ]. This step takes the pathway toward protoporphyrin IX, a c...

[ "GO:0004853", "GO:0006779" ]

[ "uroporphyrinogen decarboxylase activity", "porphyrin-containing compound biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00218", "TIGR01464", "cd00717" ]

[ "URO_D", "hemE", "URO-D" ]

[ 23064, 24519, 24636 ]

3

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.1.1.37", "GenProp0221", "GenProp1421", "GenProp1470", "GenProp1663", "GenProp1686", "GenProp1716", "GenProp1720", "PWY-5531", "PWY-7159", "PWY-7766", "R-DDI-189451", "R-DME-189451", "R-DRE-189451", "R-HSA-189451", "R-MMU-189451", "R-RNO-189451", "R-SCE-189451", "R-SPO-189451" ...

[ "EC:4.1.1.37", "GP:GenProp0221", "GP:GenProp1421", "GP:GenProp1470", "GP:GenProp1663", "GP:GenProp1686", "GP:GenProp1716", "GP:GenProp1720", "METACYC:PWY-5531", "METACYC:PWY-7159", "METACYC:PWY-7766", "REACTOME:R-DDI-189451", "REACTOME:R-DME-189451", "REACTOME:R-DRE-189451", "REACTOME:R-...

19

[ "1j93", "1jph", "1jpi", "1jpk", "1r3q", "1r3r", "1r3s", "1r3t", "1r3v", "1r3w", "1r3y", "1uro", "2eja", "2inf", "2q6z", "2q71", "3cyv", "3gvq", "3gvr", "3gvv", "3gvw", "3gw0", "3gw3", "4exq", "4wsh", "4zr8", "6w2o" ]

27

[ "PUB00006407", "PUB00080567" ]

[ "9564029", "7592567" ]

[ "Crystal structure of human uroporphyrinogen decarboxylase.", "Uroporphyrinogen decarboxylase." ]

[ 1998, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Inoviridae sp. ct6Sz5", "unclassified sequences" ]

[ 97, 19148, 5416, 1, 202 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae...

[ 8, 1, 3, 1, 8, 1, 1, 2, 3, 1, 1, 21 ]

12

true

Family

Uroporphyrinogen decarboxylase HemE

Uroporphyrinogen_deCO2ase_HemE

7

IPR006362

6,362

Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase

Cbl_synth_CobM/CibF

Domain

11,046

false

Cobalamin (vitamin B12) is a structurally complex cofactor, consisting of a modified tetrapyrrole with a centrally chelated cobalt. Cobalamin is usually found in one of two biologically active forms: methylcobalamin and adocobalamin. Most prokaryotes, as well as animals, have cobalamin-dependent enzymes, whereas plants...

[ "GO:0046026", "GO:0009236" ]

[ "precorrin-4 C11-methyltransferase activity", "cobalamin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR01465", "cd11641" ]

[ "cobM_cbiF", "Precorrin-4_C11-MT" ]

[ 10323, 11046 ]

2

[ "EC", "GP", "METACYC" ]

[ "2.1.1.133", "GenProp0275", "PWY-7376" ]

[ "EC:2.1.1.133", "GP:GenProp0275", "METACYC:PWY-7376" ]

3

[ "1cbf", "2cbf", "3ndc", "3nei", "4e16" ]

5

[ "PUB00009744", "PUB00014672", "PUB00015657", "PUB00035308", "PUB00035309", "PUB00035310", "PUB00070131" ]

[ "11215515", "11153269", "12869542", "17163662", "16042605", "12055304", "23922391" ]

[ "Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.", "Multiple biosynthetic pathways for vitamin B12: variations on a central theme.", "Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes.", "B12 trafficking in mammals: A for coenzyme escort service.", "Aerobic syn...

[ 2000, 2001, 2003, 2006, 2005, 2002, 2013 ]

7

[ "IPR000878" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 579, 10356, 13, 98 ]

4

[]

0

true

Domain

Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase

Cbl_synth_CobM/CibF

1

IPR006363

6,363

Precorrin-3B C17-methyltransferase domain

Cbl_synth_CobJ/CibH_dom

Domain

11,213

false

This entry represents a domain found in CobJ and CbiH precorrin-3B C(17)-methyltransferase ( ). In the aerobic pathway, once CobG has generated precorrin-3b, CobJ catalyses the methylation of precorrin-3b at C-17 to form precorrin-4 (the extruded methylated C-20 fragment is left attached as an acyl group at C-1) [ ]. I...

[ "GO:0008168", "GO:0009236" ]

[ "methyltransferase activity", "cobalamin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR01466", "cd11646" ]

[ "cobJ_cbiH", "Precorrin_3B_C17_MT" ]

[ 10785, 11213 ]

2

[ "EC", "GP" ]

[ "2.1.1", "GenProp0275" ]

[ "EC:2.1.1", "GP:GenProp0275" ]

2

[ "2zvb", "2zvc", "3nut" ]

3

[ "PUB00009744", "PUB00014672", "PUB00015657", "PUB00035308", "PUB00035309", "PUB00035310", "PUB00070130", "PUB00070131" ]

[ "11215515", "11153269", "12869542", "17163662", "16042605", "12055304", "23155054", "23922391" ]

[ "Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.", "Multiple biosynthetic pathways for vitamin B12: variations on a central theme.", "Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes.", "B12 trafficking in mammals: A for coenzyme escort service.", "Aerobic syn...

[ 2000, 2001, 2003, 2006, 2005, 2002, 2013, 2013 ]

8

[ "IPR000878" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 783, 10324, 10, 96 ]

4

[]

0

true

Domain

Precorrin-3B C17-methyltransferase domain

Cbl_synth_CobJ/CibH_dom

9

IPR006364

6,364

Precorrin-2 C(20)-methyltransferase domain

CobI/CbiL/CobIJ_dom

Domain

10,078

false

This entry represents a domain found in precorrin-2 C(20)-methyltransferase, one of several closely related S-adenosylmethionine-dependent methyltransferases, which introduces a methyl group at C-20 on precorrin-2 to produce precorrin-3A during cobalamin (vitamin B12) biosynthesis. This reaction is key to the conversio...

[ "GO:0008757", "GO:0009236" ]

[ "S-adenosylmethionine-dependent methyltransferase activity", "cobalamin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01467" ]

[ "cobI_cbiL" ]

[ 10078 ]

1

[ "EC", "GP", "METACYC" ]

[ "2.1.1.130", "GenProp0275", "PWY-7376" ]

[ "EC:2.1.1.130", "GP:GenProp0275", "METACYC:PWY-7376" ]

3

[ "2qbu", "8xj3" ]

2

[ "PUB00035497" ]

[ "17229157" ]

[ "Crystal structures of CbiL, a methyltransferase involved in anaerobic vitamin B biosynthesis, and CbiL in complex with S-adenosylhomocysteine--implications for the reaction mechanism." ]

[ 2007 ]

1

[ "IPR000878" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 203, 9792, 5, 78 ]

4

[]

0

true

Domain

Precorrin-2 C(20)-methyltransferase domain

CobI/CbiL/CobIJ_dom

9

IPR006365

6,365

Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase

Cbl_synth_CobL

Family

8,656

false

Cobalamin (vitamin B12) is a structurally complex cofactor, consisting of a modified tetrapyrrole with a centrally chelated cobalt. Cobalamin is usually found in one of two biologically active forms: methylcobalamin and adocobalamin. Most prokaryotes, as well as animals, have cobalamin-dependent enzymes, whereas plants...

[ "GO:0008276", "GO:0009236" ]

[ "protein methyltransferase activity", "cobalamin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF036428" ]

[ "CobL" ]

[ 8656 ]

1

[ "EC" ]

[ "2.1.1.132" ]

[ "EC:2.1.1.132" ]

1

[]

0

[ "PUB00009744", "PUB00014672", "PUB00014680", "PUB00014681", "PUB00015657", "PUB00035308", "PUB00035309", "PUB00035310", "PUB00070131" ]

[ "11215515", "11153269", "12429089", "1732195", "12869542", "17163662", "16042605", "12055304", "23922391" ]

[ "Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.", "Multiple biosynthetic pathways for vitamin B12: variations on a central theme.", "The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase.", "Biosynthesis of vitamin B12 in Pseudomonas...

[ 2000, 2001, 2002, 1992, 2003, 2006, 2005, 2002, 2013 ]

9

[ "IPR014008" ]

[]

1

0

1

[ "Bacteria", "Geodia barretti", "Thermoplasmatales", "metagenomes" ]

[ 8602, 1, 7, 46 ]

4

[]

0

true

Family

Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase

Cbl_synth_CobL

7

IPR006367

6,367

Sirohaem synthase, N-terminal

Sirohaem_synthase_N

Domain

19,035

false

Bacterial sulphur metabolism depends on the iron-containing porphinoid sirohaem. CysG is a multi-functional enzyme with S-adenosyl-L-methionine (SAM)-dependent bismethyltransferase, dehydrogenase and ferrochelatase activities. CysG synthesizes sirohaem from uroporphyrinogen III via reactions which encompass two branchp...

[ "GO:0006779", "GO:0019354" ]

[ "porphyrin-containing compound biosynthetic process", "siroheme biosynthetic process" ]

[ "biological_process", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01470" ]

[ "cysG_Nterm" ]

[ 19035 ]

1

[ "EC", "EC", "EC", "GP", "METACYC", "METACYC", "METACYC" ]

[ "1.3.1.76", "2.1.1.107", "4.99.1.4", "GenProp1215", "PWY-5194", "PWY-5196", "PWY-7377" ]

[ "EC:1.3.1.76", "EC:2.1.1.107", "EC:4.99.1.4", "GP:GenProp1215", "METACYC:PWY-5194", "METACYC:PWY-5196", "METACYC:PWY-7377" ]

7

[ "1pjq", "1pjs", "1pjt", "3dfz", "6p5x", "6p5z", "6p7c", "6p7d", "6pqz", "6pr0", "6pr1", "6pr2", "6pr3", "6pr4", "6ulu", "6veb" ]

16

[ "PUB00029889" ]

[ "14595395" ]

[ "CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 662, 16347, 1777, 249 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Sirohaem synthase, N-terminal

Sirohaem_synthase_N

4

IPR006370

6,370

4-hydroxybenzoate polyprenyltransferase-like

HB_polyprenyltransferase-like

Family

14,241

false

Members of this family show a broad specificity for prenyl diphosphates, accepting substrates of different chain lengths. Genes coding for these enzymes have been identified in many organisms, and are mostly responsible for ubiquinone (UQ) biosynthesis [ , , ]. 4-hydroxybenzoate solanesyltransferase from cyanobacteria ...

[ "GO:0004659", "GO:0016020" ]

[ "prenyltransferase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01635", "TIGR01474" ]

[ "UbiA", "ubiA_proteo" ]

[ 14144, 13488 ]

2

[ "EC", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.5.1.39", "GenProp0136", "GenProp1585", "GenProp1744", "PWY-5855", "PWY-5856", "PWY-5857", "PWY-5870", "PWY-5871", "PWY-5872", "PWY-5873", "PWY-6708", "PWY-6978", "PWY-7230", "R-CEL-1268020", "R-CEL-2142789", "R-DDI-1268020", "R-DDI-2142789", "R-DME-1268020", "R-DME-2142789",...

[ "EC:2.5.1.39", "GP:GenProp0136", "GP:GenProp1585", "GP:GenProp1744", "METACYC:PWY-5855", "METACYC:PWY-5856", "METACYC:PWY-5857", "METACYC:PWY-5870", "METACYC:PWY-5871", "METACYC:PWY-5872", "METACYC:PWY-5873", "METACYC:PWY-6708", "METACYC:PWY-6978", "METACYC:PWY-7230", "REACTOME:R-CEL-126...

28

[]

0

[ "PUB00074582", "PUB00074583", "PUB00074584", "PUB00074585", "PUB00074586", "PUB00074587", "PUB00074588" ]

[ "11744717", "2774555", "15604701", "16501255", "15153069", "22166075", "19392660" ]

[ "Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis.", "Partial purification and properties of geranyl pyrophosphate synthase from Lithospermum erythrorhizon cell cultures.", "The AtPPT1 gene encoding 4-...

[ 2002, 1989, 2004, 2006, 2004, 2012, 2009 ]

7

[ "IPR039653" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9913, 4219, 109 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 6, 1, 1, 1, 1, 3, 1, 1, 5, 4, 1, 1, 9 ]

13

true

Family

4-hydroxybenzoate polyprenyltransferase-like

HB_polyprenyltransferase-like

3

IPR006371

6,371

Polyprenyltransferase UbiA-like

Polyprenyltransferase_UbiA-li

Family

4,075

false

A fairly deep split separates this polyprenyltransferase subfamily from the set of mitochondrial and proteobacterial 4-hydroxybenzoate polyprenyltransferases, described in . Protoheme IX farnesyltransferase (heme O synthase) ( ) is more distantly related. Because no species appears to have both this protein and a membe...

[]

0

[ "NCBIFAM" ]

[ "TIGR01475" ]

[ "ubiA_other" ]

[ 4075 ]

1

[ "GP", "GP" ]

[ "GenProp0136", "GenProp0829" ]

[ "GP:GenProp0136", "GP:GenProp0829" ]

2

[ "4od4", "4od5" ]

2

[ "PUB00106614" ]

[ "24558159" ]

[ "Structural insights into ubiquinone biosynthesis in membranes." ]

[ 2014 ]

1

[ "IPR039653" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 135, 3861, 4, 75 ]

4

[]

0

true

Family

Polyprenyltransferase UbiA-like

Polyprenyltransferase_UbiA-li

1

IPR006372

6,372

Bacteriochlorophyll/chlorophyll synthetase

Chl_synth

Family

1,958

false

These are a subfamily of a large family of polyprenyltransferases that also includes 4-hydroxybenzoate octaprenyltransferase and protoheme IX farnesyltransferase (heme O synthase). Members of this family are found exclusively in photosynthetic organisms, including a single copy in Arabidopsis thaliana(Mouse-ear cress).

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR01476", "cd13958" ]

[ "chlor_syn_BchG", "PT_UbiA_chlorophyll" ]

[ 1931, 1883 ]

2

[ "GP", "GP", "GP" ]

[ "GenProp0146", "GenProp1355", "GenProp1724" ]

[ "GP:GenProp0146", "GP:GenProp1355", "GP:GenProp1724" ]

3

[]

0

[]

0

[ "IPR050475" ]

[ "IPR011799" ]

1

0

[ "Bacteria", "Eukaryota", "freshwater sediment metagenome" ]

[ 1110, 847, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 2, 6 ]

3

true

Family

Bacteriochlorophyll/chlorophyll synthetase

Chl_synth

7

IPR006373

6,373

Variant surface antigen Rifin

VSA_Rifin

Family

3,253

false

Malaria is still a major cause of mortality in many areas of the world. Plasmodium falciparum causes the most severe human form of the disease and is responsible for most fatalities. Severe cases of malaria can occur when the parasite invades and then proliferates within red blood cell erythrocytes. The parasite produc...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF02009", "TIGR01477" ]

[ "RIFIN", "RIFIN" ]

[ 3251, 2794 ]

2

[]

0

[ "7f9k", "7f9l", "7f9m", "7f9n", "7jzi", "7jzk", "7kfk", "7khf", "9f2d", "9hml" ]

10

[ "PUB00033900", "PUB00033903", "PUB00033904", "PUB00085061", "PUB00085062", "PUB00085063" ]

[ "10885986", "12368864", "14573641", "23259643", "18253504", "25751816" ]

[ "Molecular aspects of severe malaria.", "Genome sequence of the human malaria parasite Plasmodium falciparum.", "Antibodies to Plasmodium falciparum rifin proteins are associated with rapid parasite clearance and asymptomatic infections.", "Expression of a type B RIFIN in Plasmodium falciparum merozoites and ...

[ 2000, 2002, 2003, 2012, 2008, 2015 ]

6

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 3251 ]

2

[]

0

true

Family

Variant surface antigen Rifin

VSA_Rifin

5