LiteFold/InterPro · Datasets at Hugging Face

IPR006492

6,492

Plasmodium yoelii subtelomeric PYST-D

PYST_D

Family

18

false

The proteins in this set represent a paralogous family of Plasmodium yoelii genes preferentially located in the subtelomeric regions of the chromosomes. These genes are generally very short (ca. 50 residues). There are no obvious homologues to these genes in any other organism.

[]

0

[ "NCBIFAM" ]

[ "TIGR01605" ]

[ "PYST-D" ]

[ 18 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Plasmodium yoelii" ]

[ 18 ]

1

[]

0

true

Family

Plasmodium yoelii subtelomeric PYST-D

PYST_D

6

IPR006493

6,493

Holin, BlyA

Holin_BlyA

Family

109

false

This family is represented by BlyA, a small holin found in Borrelia circular plasmids that prove to be temperate phage [ ]. This protein was previously proposed to be a haemolysin. BlyA is small (67 residues) and contains two largely hydrophobic helices and a highly charged C terminus.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF05102", "TIGR01606" ]

[ "Holin_BlyA", "holin_BlyA" ]

[ 108, 90 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00009741" ]

[ "11073925" ]

[ "Characterization of Borrelia burgdorferi BlyA and BlyB proteins: a prophage-encoded holin-like system." ]

[ 2000 ]

1

[]

0

null

[ "Borreliaceae" ]

[ 109 ]

1

[]

0

true

Family

Holin, BlyA

Holin_BlyA

5

IPR006494

6,494

Plasmodium subtelomeric PST-A

PST_A

Family

653

false

These proteins represent a paralogous family of genes found in Plasmodium falciparum and Plasmodium yoelii that are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the α/β-fold superfamily of hydrolases. These genes are preferentially located in the subte...

[]

0

[ "NCBIFAM" ]

[ "TIGR01607" ]

[ "PST-A" ]

[ 653 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Plasmodium" ]

[ 653 ]

1

[]

0

true

Family

Plasmodium subtelomeric PST-A

PST_A

8

IPR006495

6,495

Citrate lyase acyl carrier protein CitD

CitD

Family

2,694

false

This group of sequences represent the acyl carrier protein (gamma subunit) of the holoenzyme citrate lyase ( ) composed of alpha ( ), beta ( ), and acyl carrier protein subunits in a stoichiometric relationship of 6:6:6. Citrate lyase is an enzyme which converts citrate to oxaloacetate. In bacteria, this reaction is in...

[ "GO:0005737" ]

[ "cytoplasm" ]

[ "cellular_component" ]

1

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_00805", "PIRSF002736", "TIGR01608" ]

[ "CitD", "Citrt_lyas_gamma", "citD" ]

[ 2199, 2520, 2694 ]

3

[ "GP" ]

[ "GenProp0672" ]

[ "GP:GenProp0672" ]

1

[]

0

[ "PUB00005807" ]

[ "9457870" ]

[ "Purification of Leuconostoc mesenteroides citrate lyase and cloning and characterization of the citCDEFG gene cluster." ]

[ 1998 ]

1

[ "IPR023439" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 2674, 20 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Citrate lyase acyl carrier protein CitD

CitD

5

IPR006496

6,496

Conserved hypothetical protein CHP01609, Plasmodium spp

CHP01606_Plasmodium_spp

Family

302

false

This entry represents a set of protein sequences found in Plasmodium species. An interesting feature is five perfectly conserved Trp residues.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09688", "TIGR01609" ]

[ "Wx5_PLAF3D7", "PF_unchar_267" ]

[ 302, 144 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Plasmodium" ]

[ 302 ]

1

[]

0

true

Family

Conserved hypothetical protein CHP01609, Plasmodium spp

CHP01606_Plasmodium_spp

6

IPR006497

6,497

Bacteriophage lambda, Replication protein O, N-terminal

Phage_lambda_VrpO_N

Domain

2,557

false

This entry represents the N-terminal domain of Replication protein O from Bacteriophage lambda and similar proteins found in tailed bacteriophages and bacterial prophages. O is necessary for the bidirectional replication of DNA. It interacts with the ori (origin of replication) region of the genome during the initiatio...

[ "GO:0006260" ]

[ "DNA replication" ]

[ "biological_process" ]

1

[ "PFAM", "NCBIFAM" ]

[ "PF04492", "TIGR01610" ]

[ "Phage_rep_O", "phage_O_Nterm" ]

[ 2557, 1992 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00099999", "PUB00100000", "PUB00100001" ]

[ "2936603", "2521755", "6264392" ]

[ "Binding and bending of the lambda replication origin by the phage O protein.", "DNA looping induced by bacteriophage lambda O protein: implications for formation of higher order structures at the lambda origin of replication.", "Purified bacteriophage lambda O protein binds to four repeating sequences at the l...

[ 1985, 1989, 1981 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 3, 2360, 8, 91, 95 ]

5

[]

0

true

Domain

Bacteriophage lambda, Replication protein O, N-terminal

Phage_lambda_VrpO_N

4

IPR006498

6,498

Tail tube protein

Tail_tube

Family

5,192

false

These sequences represent the tail tube protein of the contractile tail of phage P2, and homologous proteins from other phage [ ].

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF04985", "TIGR01611" ]

[ "Phage_tube", "tail_tube" ]

[ 5192, 3723 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "3j9q", "5w5e", "6pyt", "6u5b", "6u5f" ]

5

[ "PUB00020099" ]

[ "1825255" ]

[ "Nucleotide sequence of the genes encoding the major tail sheath and tail tube proteins of bacteriophage P2." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halolamina pelagica", "Viruses", "metagenomes" ]

[ 4956, 24, 1, 197, 14 ]

5

[]

0

true

Family

Tail tube protein

Tail_tube

2

IPR006499

6,499

Reticulocyte binding protein

Reticulocyte-bd

Family

127

false

These sequences represent a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235kDa family protein and rhoptry protein. Rhoptry protein is localised on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for ...

[]

0

[ "NCBIFAM" ]

[ "TIGR01612" ]

[ "235kDa-fam" ]

[ 127 ]

1

[]

0

[]

0

[ "PUB00009742", "PUB00009743" ]

[ "11551627", "10637585" ]

[ "The 235 kDa rhoptry protein of Plasmodium (yoelii) yoelii: function at the junction.", "Malaria multigene families: the price of chronicity." ]

[ 2001, 2000 ]

2

[]

0

null

[ "Plasmodium (Vinckeia)" ]

[ 127 ]

1

[]

0

true

Family

Reticulocyte binding protein

Reticulocyte-bd

8

IPR006500

6,500

Helicase, putative, phage/plasmid, C-terminal domain

Helicase_put_C_phage/plasmid

Domain

6,675

false

This entry represents the C-terminal domain of the putative helicase 022R from Frog virus and similar sequences found in virus and plasmids from bacteria and archaea. These sequences form a clade within a larger family of proteins from viruses of bacteria and animals.

[]

0

[ "NCBIFAM" ]

[ "TIGR01613" ]

[ "primase_Cterm" ]

[ 6675 ]

1

[]

0

[ "7ola", "7om0" ]

2

[]

0

[ "IPR051620" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 159, 5336, 132, 646, 402 ]

5

[]

0

true

Domain

Helicase, putative, phage/plasmid, C-terminal domain

Helicase_put_C_phage/plasmid

2

IPR006501

6,501

Pectinesterase inhibitor domain

Pectinesterase_inhib_dom

Domain

40,487

false

This domain inhibits pectin methylesterases (PMEs) and invertases through formation of a non-covalent 1:1 complex [ ]. It has been implicated in the regulation of fruit development, carbohydrate metabolism and cell wall extension [ ]. It may also be involved in inhibiting microbial pathogen PMEs. It has been observed t...

[ "GO:0004857" ]

[ "enzyme inhibitor activity" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART", "NCBIFAM" ]

[ "PF04043", "SM00856", "TIGR01614" ]

[ "PMEI", "PMEI", "PME_inhib" ]

[ 39671, 36499, 36465 ]

3

[ "EC", "METACYC", "METACYC" ]

[ "3.1.1.11", "PWY-7246", "PWY-7248" ]

[ "EC:3.1.1.11", "METACYC:PWY-7246", "METACYC:PWY-7248" ]

3

[ "1rj1", "1rj4", "1x8z", "1x90", "1x91", "1xg2", "2cj4", "2cj5", "2cj6", "2cj7", "2cj8", "2xqr" ]

12

[ "PUB00009644", "PUB00010585" ]

[ "10880981", "8521860" ]

[ "Kiwi protein inhibitor of pectin methylesterase amino-acid sequence and structural importance of two disulfide bridges.", "A glycoprotein inhibitor of pectin methylesterase in kiwi fruit. Purification by affinity chromatography and evidence of a ripening-related precursor." ]

[ 2000, 1995 ]

2

[]

0

null

[ "Alteraurantiacibacter buctensis", "Eukaryota" ]

[ 1, 40486 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 510, 172, 213 ]

3

true

Domain

Pectinesterase inhibitor domain

Pectinesterase_inhib_dom

8

IPR006502

6,502

Protein of unknown function PDDEXK-like

PDDEXK-like

Family

6,990

false

PDDEXK_6 is a family of plant proteins that are distant homologues of the PD-(D/E)XK nuclease superfamily. The core structure is retained, as α-β-β-β-α-β. It retains the characteristic PDDEXK motifs II and III in modified forms - xDxxx motif located in the second core β-strand, where x is any hydrophobic residue, and a...

[]

0

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF04720", "PTHR31579", "TIGR01615" ]

[ "PDDEXK_6", "", "A_thal_3542" ]

[ 6987, 6756, 6175 ]

3

[]

0

[]

0

[ "PUB00044133", "PUB00075365" ]

[ "17584917", "22936940" ]

[ "Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families with modified transitive meta profile searches.", "Conserved Peptide Upstream Open Reading Frames are Associated with Regulatory Genes in Angiosperms." ]

[ 2007, 2012 ]

2

[]

0

null

[ "Eukaryota", "Meridianimaribacter flavus" ]

[ 6989, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 64, 41, 39 ]

3

true

Family

Protein of unknown function PDDEXK-like

PDDEXK-like

5

IPR006503

6,503

Nitrogenase-associated protein

Nase-assoc

Family

678

false

This set of sequences describe a small family of uncharacterised proteins only found so far in alpha and gamma proteobacteria and in the Cyanobacterium Anabaena sp. (strain PCC 7120). The gene for this protein is associated with nitrogenase genes. This family shows sequence similarity to glutaredoxin-dependent arsenate...

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR01616", "cd03033" ]

[ "nitro_assoc", "ArsC_15kD" ]

[ 678, 388 ]

2

[]

0

[]

0

[]

0

[ "IPR006660" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 669, 9 ]

2

[]

0

true

Family

Nitrogenase-associated protein

Nase-assoc

4

IPR006504

6,504

Transcriptional regulator Spx/MgsR

Tscrpt_reg_Spx/MgsR

Family

16,728

false

Characterised members of this family include Spx and MgsR from Bacillus subtilis. Spx is a global transcription regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Induces the expression of a large number of genes in response to a variety of stress conditions, ...

[]

0

[ "NCBIFAM" ]

[ "TIGR01617" ]

[ "arsC_related" ]

[ 16728 ]

1

[]

0

[ "1rw1", "1z3e", "2kok", "2m46", "3fz4", "3gfk", "3gkx", "3ihq", "3l78", "6ghb", "6gho", "7f75" ]

12

[ "PUB00057340", "PUB00057826", "PUB00095599" ]

[ "18643936", "18687074", "29271514" ]

[ "The Spx paralogue MgsR (YqgZ) controls a subregulon within the general stress response of Bacillus subtilis.", "Activation of transcription initiation by Spx: formation of transcription complex and identification of a Cis-acting element required for transcriptional activation.", "Induction of the Spx regulon b...

[ 2008, 2008, 2018 ]

3

[ "IPR006660" ]

[ "IPR023731" ]

1

0

[ "Bacteria", "Eukaryota", "Methanobrevibacter", "unclassified sequences" ]

[ 16606, 9, 12, 101 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcriptional regulator Spx/MgsR

Tscrpt_reg_Spx/MgsR

4

IPR006505

6,505

Phage nucleotide-binding protein

Phage_nucleotide-bp

Family

531

false

These sequences represent an uncharacterised family of proteins from a number of phage of Gram-positive bacteria, including Streptococcus phage Sfi11 and Lactobacillus phage JNU_P5. This protein contains a P-loop motif, G/A-X-X-G-X-G-K-T near its amino end. The characteristics of the protein distribution suggest propha...

[]

0

[ "NCBIFAM" ]

[ "TIGR01618" ]

[ "phage_P_loop" ]

[ 531 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 430, 101 ]

2

[]

0

true

Family

Phage nucleotide-binding protein

Phage_nucleotide-bp

4

IPR006506

6,506

Conserved hypothetical protein CHP01619

CHP01619

Family

332

false

These sequences represent a hypothetical equivalog of gamma proteobacteria, which includes HI0040.

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF017962", "TIGR01619" ]

[ "UCP017962", "hyp_HI0040" ]

[ 310, 104 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 332 ]

1

[]

0

true

Family

Conserved hypothetical protein CHP01619

CHP01619

7

IPR006507

6,507

Uncharacterised protein family UPF0283

UPF0283

Family

4,830

false

These are putative membrane proteins from alpha and gamma proteobacteria, each making up their own clade. The two clades have less than 25% identity between them.

[]

0

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_01085", "PTHR39342", "TIGR01620" ]

[ "UPF0283", "", "hyp_HI0043" ]

[ 2282, 4830, 4607 ]

3

[]

0

[]

0

[]

0

[ "IPR021147" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4809, 4, 17 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0283

UPF0283

2

IPR006508

6,508

Pseudouridine synthase, RluA-like

PsdUridine_synth_RluA-like

Family

1,224

false

Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine (Psi) in a variety of RNA molecules, and may function as RNA chaperones. Pseudouridine is the most abundant modified nucleotide found in all cellular RNAs. There are four distinct families of pseudouridine synthases that share no global sequ...

[]

0

[ "NCBIFAM" ]

[ "TIGR01621" ]

[ "RluA-like" ]

[ 1224 ]

1

[]

0

[]

0

[ "PUB00009645", "PUB00045922", "PUB00092579" ]

[ "10383384", "10529181", "19664587" ]

[ "Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA.", "Role of cysteine residues in pseudouridine synthases of different families.", "Enzymatic characterization and mutational studies of TruD--the fifth family of pseudouridine synthases." ]

[ 1999, 1999, 2009 ]

3

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1221, 3 ]

2

[]

0

true

Family

Pseudouridine synthase, RluA-like

PsdUridine_synth_RluA-like

4

IPR006510

6,510

Zinc finger, lateral root primordium type 1

Znf_LRP1

Domain

3,502

false

These sequences contain a putative zinc finger domain found predominantly in plants. Arabidopsis thaliana (Mouse-ear cress) has at least 10 distinct members. Proteins containing this domain, including LRP1 (lateral root primordium 1)[ ], generally share the same size, about 300 amino acids, and architecture. This 43-re...

[]

0

[ "NCBIFAM" ]

[ "TIGR01623" ]

[ "put_zinc_LRP1" ]

[ 3502 ]

1

[]

0

[]

0

[ "PUB00007958", "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "7647564", "12665246", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "LRP1, a gene expressed in lateral and adventitious root primordia of arabidopsis.", "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc...

[ 1995, 2002, 2007, 2005, 2005, 1999, 2001 ]

7

[]

0

null

[ "Streptophytina" ]

[ 3502 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 45, 14, 25 ]

3

true

Domain

Zinc finger, lateral root primordium type 1

Znf_LRP1

7

IPR006511

6,511

Short internodes, C-terminal

SHI_C

Domain

3,583

false

These sequences contain a tightly conserved small domain found in Short internodes (SHI) and related plant proteins. SHI proteins also contain a well-conserved adjacent N-terminal putative zinc finger domain ( ). SHI may act as a negative regulator of GA responses through transcriptional control [ , ].

[]

0

[ "NCBIFAM" ]

[ "TIGR01624" ]

[ "LRP1_Cterm" ]

[ 3583 ]

1

[]

0

[]

0

[ "PUB00083348" ]

[ "10368174" ]

[ "The Arabidopsis dwarf mutant shi exhibits reduced gibberellin responses conferred by overexpression of a new putative zinc finger protein." ]

[ 1999 ]

1

[]

0

null

[ "Bowmanella dokdonensis", "Streptophytina" ]

[ 1, 3582 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 43, 14, 26 ]

3

true

Domain

Short internodes, C-terminal

SHI_C

5

IPR006512

6,512

YidE/YbjL duplication

YidE_YbjL

Domain

9,051

false

These sequences contain a domain that is duplicated in HI0035 of Haemophilus influenzae, in YidE and YbjL of Escherichia coli, and in a number of other putative transporters. Member proteins may have 0, 1, or 2 copies of the TrkA-C potassium uptake domain ( ) between the duplications. The duplication appears distantly ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF06826", "TIGR01625" ]

[ "Asp-Al_Ex", "YidE_YbjL_dupl" ]

[ 9051, 8539 ]

2

[]

0

[ "8xw5", "8y1x", "9oqy", "9vdc", "9veb" ]

5

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 8918, 12, 22, 99 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

YidE/YbjL duplication

YidE_YbjL

3

IPR006513

6,513

YtfJ-like family

YtfJ_HI0045

Family

2,263

false

These are sequences from gammaproteobacteria that are related to the Escherichia coli protein, YtfJ. It is predicted to adopt Thioredoxin-like fold, particularly similar to Glutathione peroxidase family ( ).

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09695", "TIGR01626" ]

[ "YtfJ_HI0045", "ytfJ_HI0045" ]

[ 2263, 2044 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Ecdysozoa", "metagenomes" ]

[ 2240, 4, 19 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YtfJ-like family

YtfJ_HI0045

1

IPR006514

6,514

IRX15/GXM/AGM

Family

4,335

false

This entry includes IRREGULAR XYLEM IRX15/IRX15L, glucuronoxylan 4-O-methyltransferases 1(GXM1), 2(GXM2) and 3(GXM3) from plants. GXMs and IRX15/15L are all expressed in secondary wall-forming cells and they are all involved in xylan biosynthesis. However, they have different functions [ ]. GXM1/GXM2/GXM3 are methyltra...

[ "GO:0045492" ]

[ "xylan biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF21729", "PTHR31444", "TIGR01627" ]

[ "IRX15_IRX15L_GXM", "", "A_thal_3515" ]

[ 4322, 4264, 3872 ]

3

[]

0

[]

0

[ "PUB00076852", "PUB00076853", "PUB00103824" ]

[ "23045523", "24576763", "31245760" ]

[ "Three Arabidopsis DUF579 domain-containing GXM proteins are methyltransferases catalyzing 4-o-methylation of glucuronic acid on xylan.", "Modification of the degree of 4-O-methylation of secondary wall glucuronoxylan.", "Two members of the DUF579 family are responsible for arabinogalactan methylation in Arabid...

[ 2012, 2014, 2019 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Terrestrivirus sp.", "metagenomes" ]

[ 27, 4304, 1, 3 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 36, 25, 35 ]

3

true

Family

IRX15/GXM/AGM

5

IPR006515

6,515

Polyadenylate binding protein, human types 1, 2, 3, 4

PABP_1234

Family

10,834

false

These eukaryotic proteins recognise the poly-A of mRNA and consist of four tandem RNA recognition domains at the N terminus followed by a PABP-specific domain at the C terminus. The protein is involved in the transport of mRNAs from the nucleus to the cytoplasm [ ]. There are four paralogs in Homo sapiens (Human) which...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01628" ]

[ "PABP-1234" ]

[ 10834 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-429947", "R-BTA-450408", "R-BTA-72649", "R-BTA-975956", "R-BTA-975957", "R-DRE-156827", "R-DRE-450408", "R-DRE-975956", "R-DRE-975957", "R-HSA-156827", "R-HSA-429947", "R-HSA-450408", "R-HSA-72649", "R-HSA-9010553", "R-HSA-975956", "R-HSA-975957", "R-HSA-9820...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-429947", "REACTOME:R-BTA-450408", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-DRE-156827", "REACTOME:R-DRE-450408", "REACTOME:R-DRE-975956", "REACTOME:R-DRE-975957", "REACTOME:R-HSA-156827", "REACTOME:R-HSA-4299...

31

[ "6r5k" ]

1

[ "PUB00007959", "PUB00007960", "PUB00007961" ]

[ "9582337", "11328870", "8524242" ]

[ "The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm.", "Human testis expresses a specific poly(A)-binding protein.", "iPABP, an inducible poly(A)-binding protein detected in activated human T cells." ]

[ 1998, 2001, 1995 ]

3

[]

0

null

[ "Eukaryota", "Kangiella spongicola" ]

[ 10833, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 23, 4, 8, 1, 25, 16, 1, 14, 17, 1, 1, 43 ]

12

true

Family

Polyadenylate binding protein, human types 1, 2, 3, 4

PABP_1234

1

IPR006516

6,516

Replication-associated protein G2P

G2P

Family

573

false

This entry represents a family of phage and plasmid replication proteins. In bacteriophage IKe and related phage, the full-length protein is designated gene II protein (G2P). A much shorter protein of unknown function, translated from a conserved in-frame alternative initiator, is designated gene X protein (G10P). Memb...

[ "GO:0006260" ]

[ "DNA replication" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR01629" ]

[ "rep_II_X" ]

[ 573 ]

1

[ "EC", "EC" ]

[ "3.1.21.-", "6.5.1.1" ]

[ "EC:3.1.21.-", "EC:6.5.1.1" ]

2

[]

0

[]

0

[]

0

null

[ "Bacteria", "Inoviridae", "Rhabditida", "unclassified sequences" ]

[ 523, 29, 3, 18 ]

4

[]

0

true

Family

Replication-associated protein G2P

G2P

1

IPR006517

6,517

Phage terminase large subunit-like, C-terminal domain

Phage_terminase_lsu-like_C

Domain

4,142

false

This entry represents the C-terminal domain of a group of proteins from tailed bacteriophages that are typically about 400-500 amino acids in length, although some members are considerably shorter. Most proteins in this family have an apparent P-loop nucleotide-binding sequence toward the N terminus, consistent with th...

[]

0

[ "NCBIFAM" ]

[ "TIGR01630" ]

[ "psiM2_ORF9" ]

[ 4142 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00005832", "PUB00106624" ]

[ "9791169", "17615066" ]

[ "Molecular analysis of Methanobacterium phage psiM2.", "Characterization of the dsDNA prophage sequences in the genome of Neisseria gonorrhoeae and visualization of productive bacteriophage." ]

[ 1998, 2007 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 15, 2922, 29, 1020, 156 ]

5

[]

0

true

Domain

Phage terminase large subunit-like, C-terminal domain

Phage_terminase_lsu-like_C

3

IPR006518

6,518

Trypanosome RHS

Trypano_RHS

Family

3,047

false

These sequences are full-length and part-length members of the RHS (retrotransposon hot spot) family in Trypanosoma brucei and Trypanosoma cruzi. Members of this family are frequently interrupted by non-LTR retrotransposons inserted at exactly the same relative position [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR01631" ]

[ "Trypano_RHS" ]

[ 3047 ]

1

[]

0

[]

0

[ "PUB00020247" ]

[ "12455980" ]

[ "A new, expressed multigene family containing a hot spot for insertion of retroelements is associated with polymorphic subtelomeric regions of Trypanosoma brucei." ]

[ 2002 ]

1

[]

0

null

[ "Trypanosoma" ]

[ 3047 ]

1

[]

0

true

Family

Trypanosome RHS

Trypano_RHS

1

IPR006519

6,519

Large ribosomal subunit protein uL11, bacteria

Ribosomal_uL11_bact

Family

27,509

false

Ribosomal protein uL11 is one of the proteins from the large ribosomal subunit. In Escherichia coli, uL11 is known to bind directly to the 23S rRNA. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [ ], groups bacterial, chloroplast, cyanelle, and most mitochondrial forms of rib...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01632" ]

[ "L11_bact" ]

[ 27509 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840", "R-RNO-5419276", "R-RNO-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383", "REACTOME:R-RNO-5389840", "REACTOM...

13

[ "1eg0", "1jqm", "1jqs", "1jqt", "1mj1", "1ml5", "1mms", "1mvr", "1nkw", "1nwx", "1nwy", "1oln", "1pn7", "1pn8", "1r2w", "1r2x", "1sm1", "1xbp", "2e34", "2e35", "2e36", "2ftc", "2h8w", "2j28", "2jq7", "2k3f", "2klm", "2nxn", "2rdo", "2zjp", "2zjq", "2zjr"...

602

[ "PUB00000269", "PUB00004378", "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "2483975", "2167467", "11297922", "11290319", "11114498" ]

[ "Structural properties of ribosomal protein L11 from Escherichia coli.", "The 26S rRNA binding ribosomal protein equivalent to bacterial protein L11 is encoded by unspliced duplicated genes in Saccharomyces cerevisiae.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end ...

[ 1989, 1990, 2001, 2001, 2000 ]

5

[ "IPR000911" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2, 23189, 3898, 420 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...

[ 6, 1, 1, 2, 2, 1, 6, 3, 1, 1, 5 ]

11

true

Family

Large ribosomal subunit protein uL11, bacteria

Ribosomal_uL11_bact

3

IPR006521

6,521

Tail protein I

Tail_protein_I

Family

8,684

false

These sequences represent a family of phage tail proteins from phage P2 protein and related temperates phage of Gram-negative bacteria.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09684", "TIGR01634" ]

[ "Tail_P2_I", "tail_P2_I" ]

[ 8682, 5264 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "6u5b", "6u5k", "9gtp" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "Viruses", "metagenomes" ]

[ 8350, 17, 56, 237, 24 ]

5

[]

0

true

Family

Tail protein I

Tail_protein_I

3

IPR006522

6,522

Phage virion morphogensis protein

Phage_virion_morphogenesis

Family

6,094

false

This entry represents a number of known and suspected phage virion morphogenesis proteins. The S protein from phage P2 is thought to act in tail completion and stable head joining [ ].

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF05069", "TIGR01635" ]

[ "Phage_tail_S", "tail_comp_S" ]

[ 6090, 4560 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00012904" ]

[ "8178426" ]

[ "Molecular cloning and characterization of bacteriophage P2 genes R and S involved in tail completion." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 5671, 6, 9, 352, 56 ]

5

[]

0

true

Family

Phage virion morphogensis protein

Phage_virion_morphogenesis

9

IPR006523

6,523

Transcription activator RinA

RinA

Family

1,051

false

These sequences represent a family of phage (and phage-related) proteins, including RinA, a transcriptional activator in staphylococcal phage phi 11. This family shows similarity to ArpU, a phage-related putative autolysin regulator, and to some sporulation-specific sigma factors [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR01636" ]

[ "phage_rinA" ]

[ 1051 ]

1

[]

0

[]

0

[ "PUB00009648" ]

[ "8432703" ]

[ "Cloning, sequencing, and genetic characterization of regulatory genes, rinA and rinB, required for the activation of staphylococcal phage phi 11 int expression." ]

[ 1993 ]

1

[]

0

null

[ "Bacteria", "Halobaculum halobium", "Viruses", "metagenomes" ]

[ 896, 1, 150, 4 ]

4

[]

0

true

Family

Transcription activator RinA

RinA

6

IPR006524

6,524

Putative autolysin regulatory protein ArpU-like

ArpU-like

Family

2,510

false

This entry represents a group of proteins that includes Putative autolysin regulatory protein ArpU. ArpU was originally described as a regulator of cellular muramidase-2 of Enterococcus hirae [ ], but appears to have been cloned from a prophage. This family appears related to the RinA family of bacteriophage transcript...

[]

0

[ "NCBIFAM" ]

[ "TIGR01637" ]

[ "phage_arpU" ]

[ 2510 ]

1

[]

0

[]

0

[ "PUB00099978", "PUB00099979" ]

[ "21450808", "7592343" ]

[ "RinA controls phage-mediated packaging and transfer of virulence genes in Gram-positive bacteria.", "Identification of a gene (arpU) controlling muramidase-2 export in Enterococcus hirae." ]

[ 2011, 1995 ]

2

[]

0

null

[ "Bacteria", "Viruses" ]

[ 2343, 167 ]

2

[]

0

true

Family

Putative autolysin regulatory protein ArpU-like

ArpU-like

5

IPR006525

6,525

Cystatin-related, plant

Cystatin-related_pln

Domain

1,468

false

Sequences with this domain represent a family similar in sequence and probably homologous to a large family of cysteine proteinase inhibitors, or cystatins, as described by . These proteins are only found in dicots. Cystatins may help plants resist attack by insects.

[]

0

[ "NCBIFAM" ]

[ "TIGR01638" ]

[ "Atha_cystat_rel" ]

[ 1468 ]

1

[]

0

[ "2l4v", "4n6t", "4n6u", "6qoz" ]

4

[]

0

[]

0

null

[ "Mesangiospermae" ]

[ 1468 ]

1

[ "Arabidopsis thaliana" ]

[ 94 ]

1

true

Domain

Cystatin-related, plant

Cystatin-related_pln

9

IPR006526

6,526

Exported protein, PHISTa/b/c, conserved domain, Plasmodium

Export_prot_PHISTa/b/c

Domain

1,389

false

This entry represents a conserved domain of about 60 amino acids that is found in several paralogues from Plasmodium falciparum, the apicomplexan parasite that causes the most severe form of malaria in humans. This domain is not currently found elsewhere, even in closely related Plasmodium species. Proteins that contai...

[]

0

[ "NCBIFAM" ]

[ "TIGR01639" ]

[ "P_fal_TIGR01639" ]

[ 1389 ]

1

[]

0

[ "4jle", "7d2w" ]

2

[ "PUB00053439" ]

[ "16507167" ]

[ "Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites." ]

[ 2006 ]

1

[]

0

null

[ "Plasmodium", "Psychroflexus salis" ]

[ 1388, 1 ]

2

[]

0

true

Domain

Exported protein, PHISTa/b/c, conserved domain, Plasmodium

Export_prot_PHISTa/b/c

8

IPR006527

6,527

F-box associated beta-propeller, type 1

F-box-assoc_dom_typ1

Domain

26,884

false

This β-propeller domain occurs in a diverse superfamily of genes in plants. Most examples are found C-terminal to an F-box ( ), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of...

[]

0

[ "PFAM" ]

[ "PF07734" ]

[ "FBA_1" ]

[ 26884 ]

1

[]

0

[]

0

[ "PUB00009649" ]

[ "12169662" ]

[ "The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis." ]

[ 2002 ]

1

[ "IPR017451" ]

[]

1

0

1

[ "Eukaryota", "Flavivirga algicola" ]

[ 26883, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 675, 37, 3 ]

3

true

Domain

F-box associated beta-propeller, type 1

F-box-assoc_dom_typ1

7

IPR006528

6,528

Phage head morphogenesis domain

Phage_head_morphogenesis_dom

Domain

9,990

false

This domain is found in proteins found in the tailed bacteriophages Caudovirales and in bacterial prophages, internally or toward the C terminus. Minor head protein GP7 from Bacillus phage SPP1 is required for viral head morphogenesis [ ]. Gp7 binds the viral DNA inside the capsid and the portal protein and may control...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF04233", "TIGR01641" ]

[ "Phage_Mu_F", "phageSPP1_gp7" ]

[ 9845, 5832 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00056246", "PUB00056247", "PUB00100007" ]

[ "9180375", "1385991", "16899078" ]

[ "Head morphogenesis genes of the Bacillus subtilis bacteriophage SPP1.", "DNA sequence characterization of the G gene region of bacteriophage Mu.", "The minor capsid protein gp7 of bacteriophage SPP1 is required for efficient infection of Bacillus subtilis." ]

[ 1997, 1992, 2006 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 73, 8264, 28, 1389, 236 ]

5

[]

0

true

Domain

Phage head morphogenesis domain

Phage_head_morphogenesis_dom

6

IPR006529

6,529

U2 snRNP auxilliary factor, large subunit, splicing factor

U2AF_lg

Family

5,701

false

These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs. The well-characterised members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-li...

[ "GO:0003723", "GO:0006397", "GO:0005634" ]

[ "RNA binding", "mRNA processing", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01642" ]

[ "U2AF_lg" ]

[ 5701 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-159236", "R-CEL-72187", "R-CEL-73856", "R-CEL-9629569", "R-DME-159236", "R-DME-72187", "R-DME-73856", "R-DME-9629569", "R-HSA-159236", "R-HSA-72163", "R-HSA-72187", "R-HSA-73856", "R-HSA-9629569", "R-MMU-159236", "R-MMU-72163", "R-MMU-72187", "R-MMU-73856", "R-MMU-9629569" ]

[ "REACTOME:R-CEL-159236", "REACTOME:R-CEL-72187", "REACTOME:R-CEL-73856", "REACTOME:R-CEL-9629569", "REACTOME:R-DME-159236", "REACTOME:R-DME-72187", "REACTOME:R-DME-73856", "REACTOME:R-DME-9629569", "REACTOME:R-HSA-159236", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72187", "REACTOME:R-HSA-73856",...

18

[ "2yh0", "2yh1", "5ev1", "5ev2", "5ev3", "5ev4", "6tr0", "6xlv", "6xlw", "6xlx", "7s3a", "7s3b", "7s3c", "9c7a", "9c7b" ]

15

[]

0

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 5700, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 13, 1, 13, 6, 2, 5, 1, 5, 2, 1, 45 ]

11

true

Family

U2 snRNP auxilliary factor, large subunit, splicing factor

U2AF_lg

7

IPR006530

6,530

YD repeat

YD

Repeat

39,925

false

These sequences contain two tandem copies of a 21-residue extracellular repeat that is found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken ...

[]

0

[ "NCBIFAM" ]

[ "TIGR01643" ]

[ "YD_repeat_2x" ]

[ 39925 ]

1

[]

0

[ "6cmx", "6fay", "6fb3", "6ska", "6ske", "7bam", "7ban", "7bao", "7pq5", "7q97", "8cp6", "8fia", "8h8a", "8h8b", "8h8c", "8qja", "8qjb", "8qjc", "8qjd", "8r50", "8r51", "8r54", "8uxt", "8uy4" ]

24

[ "PUB00002114", "PUB00003864", "PUB00009650" ]

[ "2403547", "7934896", "10341219" ]

[ "Structure of the rhsA locus from Escherichia coli K-12 and comparison of rhsA with other members of the rhs multigene family.", "Rhs elements of Escherichia coli: a family of genetic composites each encoding a large mosaic protein.", "Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, i...

[ 1990, 1994, 1999 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 29, 30605, 9, 9088, 194 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 146, 8, 4, 14, 11, 34 ]

6

true

Repeat

YD repeat

YD

1

IPR006531

6,531

Gp5/Type VI secretion system Vgr protein, OB-fold domain

Gp5/Vgr_OB

Domain

30,071

false

This domain occurs in a family of phage (and bacteriocin) proteins related to the phage P2 V gene product, which forms the small spike at the tip of the tail [ ]. Homologs in general are annotated as baseplate assembly protein V. At least one member is encoded within a region of Pectobacterium carotovorum (Erwinia caro...

[]

0

[ "PFAM" ]

[ "PF04717" ]

[ "Phage_base_V" ]

[ 30071 ]

1

[]

0

[ "2p5z", "3qr8", "4mtk", "4s37", "4uhv", "6h3l", "6h3n", "6j0m", "6rbk", "6sjl", "6sk0", "6ski", "7aef", "7b5h", "7q5p", "8gra", "8kea", "8qja", "9gtr", "9jg8", "9jg9", "9qgm" ]

22

[ "PUB00008577", "PUB00048623", "PUB00054068" ]

[ "7483254", "19251641", "17873062" ]

[ "Bacteriophage P2: genes involved in baseplate assembly.", "Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.", "Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin." ]

[ 1995, 2009, 2007 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 60, 29611, 47, 222, 131 ]

5

[]

0

true

Domain

Gp5/Type VI secretion system Vgr protein, OB-fold domain

Gp5/Vgr_OB

3

IPR006532

6,532

Poly-U binding splicing factor, PUF60-like

PUF60-like

Family

2,707

false

Proteins in this family are DNA- and/or RNA-binding proteins involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation [ , ], containing three RNA recognition motifs [ , , ]. In the case of PUF60, in complex with p54, and in the presence of U2AF, it facilitates association ...

[ "GO:0003723", "GO:0000381" ]

[ "RNA binding", "regulation of alternative mRNA splicing, via spliceosome" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01645" ]

[ "half-pint" ]

[ 2707 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-72163", "R-DME-72163", "R-DRE-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-CEL-72163", "REACTOME:R-DME-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

6

[]

0

[ "PUB00009653", "PUB00009654", "PUB00009655", "PUB00082878", "PUB00096635" ]

[ "11879639", "10606266", "10668799", "17579712", "32538777" ]

[ "Half pint regulates alternative splice site selection in Drosophila.", "PUF60: a novel U2AF65-related splicing activity.", "Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins.", "Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF...

[ 2002, 1999, 2000, 2007, 2020 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2707 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 12, 2, 5, 2, 8 ]

6

true

Family

Poly-U binding splicing factor, PUF60-like

PUF60-like

5

IPR006533

6,533

Type VI secretion system, RhsGE-associated Vgr protein

T6SS_Vgr_RhsGE

Family

20,599

false

This entry represent the Vgr family of proteins, associated with some classes of Rhs elements (Rhs classes G and E). Rhs (rearrangement hot-spot) elements are repetitious sequences identified in certain Escherichia coli strains [ , ]. Type VI secretion system (T6SS) appears to be confined to Proteobacteria. It is impor...

[]

0

[ "NCBIFAM" ]

[ "TIGR01646" ]

[ "vgr_GE" ]

[ 20599 ]

1

[]

0

[ "2p5z", "4mtk", "4uhv", "6h3l", "6h3n", "6sjl", "6sk0", "6ski", "7aef", "7b5h", "7q5p", "8qja" ]

12

[ "PUB00009657", "PUB00034462", "PUB00042938", "PUB00067798", "PUB00067801", "PUB00067820" ]

[ "9696756", "16763151", "16432199", "15385502", "19284603", "10673005" ]

[ "Rhs elements comprise three subfamilies which diverged prior to acquisition by Escherichia coli.", "A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.", "Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system...

[ 1998, 2006, 2006, 2004, 2009, 1999 ]

6

[]

[ "IPR017847" ]

0

1

0

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 20476, 5, 31, 87 ]

4

[]

0

true

Family

Type VI secretion system, RhsGE-associated Vgr protein

T6SS_Vgr_RhsGE

1

IPR006534

6,534

P-type ATPase, subfamily IIIA

P-type_ATPase_IIIA

Family

10,642

false

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ...

[ "GO:0008553", "GO:0120029", "GO:0016020" ]

[ "P-type proton-exporting transporter activity", "proton export across plasma membrane", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR01647", "cd02076" ]

[ "ATPase-IIIA_H", "P-type_ATPase_H" ]

[ 10424, 8702 ]

2

[ "EC" ]

[ "7.1.2.1" ]

[ "EC:7.1.2.1" ]

1

[ "1mhs", "5ksd", "7nxf", "7ny1", "7vh5", "7vh6", "9ugb", "9ugc" ]

8

[ "PUB00009616", "PUB00009658", "PUB00020603", "PUB00020604", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00160065", "PUB00160066" ]

[ "9419228", "1288321", "15473999", "15078220", "20450191", "18937357", "1385979", "9741106", "37264943", "37838176" ]

[ "Evolution of substrate specificities in the P-type ATPase superfamily.", "Structure and function of the yeast plasma-membrane H(+)-ATPase.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-discip...

[ 1998, 1992, 2004, 2004, 2010, 2008, 1992, 1998, 2023, 2023 ]

10

[ "IPR001757" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Terrestrivirus sp.", "unclassified sequences" ]

[ 136, 606, 9849, 1, 50 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 51, 1, 35, 2, 2, 66 ]

6

true

Family

P-type ATPase, subfamily IIIA

P-type_ATPase_IIIA

7

IPR006535

6,535

HnRNP R/Q splicing factor

HnRNP_R/Q_splicing_fac

Family

9,028

false

Sequences in this subfamily include the human heterogeneous nuclear ribonucleoproteins (hnRNP) R [ ], Q [ ] and APOBEC-1 complementation factor (aka APOBEC-1 stimulating protein) [ ]. These proteins contain three RNA recognition domains and a somewhat variable C-terminal domain.

[]

0

[ "NCBIFAM" ]

[ "TIGR01648" ]

[ "hnRNP-R-Q" ]

[ 9028 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-HSA-72200", "R-HSA-72203", "R-HSA-75094", "R-MMU-72200", "R-MMU-75094", "R-RNO-72200", "R-RNO-75094" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72200", "REACTOME:R-HSA-72203", "REACTOME:R-HSA-75094", "REACTOME:R-MMU-72200", "REACTOME:R-MMU-75094", "REACTOME:R-RNO-72200", "REACTOME:R-RNO-75094" ]

8

[ "6kor" ]

1

[ "PUB00009659", "PUB00009660", "PUB00009661" ]

[ "9421497", "11574476", "10781591" ]

[ "Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P.", "SMN interacts with a novel family of hnRNP and spliceosomal proteins.", "Purification and molecular cloning of a novel essential component of the apolipoprotein B m...

[ 1998, 2001, 2000 ]

3

[]

0

null

[ "Eukaryota" ]

[ 9028 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 35, 20, 34, 25, 26 ]

6

true

Family

HnRNP R/Q splicing factor

HnRNP_R/Q_splicing_fac

1

IPR006536

6,536

HnRNP-L/PTB

Family

10,973

false

Included in this family of heterogeneous ribonucleoproteins are PTB (polypyrimidine tract binding protein [ ]) and hnRNP-L [ ]. These proteins contain four RNA recognition motifs.

[ "GO:0003723", "GO:0006397", "GO:0005634" ]

[ "RNA binding", "mRNA processing", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01649" ]

[ "hnRNP-L_PTB" ]

[ 10973 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6803529", "R-BTA-72163", "R-BTA-72203", "R-HSA-6803529", "R-HSA-72163", "R-HSA-72203", "R-MMU-6803529", "R-MMU-72163", "R-MMU-72203", "R-RNO-6803529", "R-RNO-72163", "R-RNO-72203" ]

[ "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72203", "REACTOME:R-HSA-6803529", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72203", "REACTOME:R-MMU-6803529", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72203", "REACTOME:R-RNO-6803529", "REACTOME:R-RNO-72163", "REACTOME:R-RNO-72203"...

12

[ "1qm9", "2adc", "2evz", "2mju", "2mqn", "2mqq", "3s01", "3to8", "3tyt", "4cq1", "4qpt" ]

11

[ "PUB00009662", "PUB00009663" ]

[ "11804786", "7542615" ]

[ "Lineage-specific expression of polypyrimidine tract binding protein (PTB) in Drosophila embryos.", "HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression." ]

[ 2002, 1995 ]

2

[]

0

null

[ "Eukaryota" ]

[ 10973 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 25, 21, 40, 29, 2, 34, 4 ]

8

true

Family

HnRNP-L/PTB

2

IPR006537

6,537

Cobaltochelatase subunit CobS

PD_CobS

Family

2,708

false

These sequences are related to the Pseudomonas denitrificans CobS gene product, which is a cobalt chelatase subunit of MW ~37kDa [ ] that functions in cobalamin biosynthesis. Cobalamin (vitamin B12) can be synthesized via several pathways, including an aerobic pathway (found in P. denitrificans) and an anaerobic pathwa...

[]

0

[ "NCBIFAM" ]

[ "TIGR01650" ]

[ "PD_CobS" ]

[ 2708 ]

1

[]

0

[]

0

[ "PUB00006361", "PUB00009664", "PUB00009744", "PUB00009745" ]

[ "8905078", "1429466", "11215515", "7592411" ]

[ "Cobalamin (coenzyme B12): synthesis and biological significance.", "Assay, purification, and characterization of cobaltochelatase, a unique complex enzyme catalyzing cobalt insertion in hydrogenobyrinic acid a,c-diamide during coenzyme B12 biosynthesis in Pseudomonas denitrificans.", "Biosynthesis of cobalamin...

[ 1996, 1992, 2000, 1995 ]

4

[]

0

null

[ "Pseudomonadati", "Symbiodiniaceae", "metagenomes" ]

[ 2678, 5, 25 ]

3

[]

0

true

Family

Cobaltochelatase subunit CobS

PD_CobS

9

IPR006538

6,538

Cobalt chelatase, CobT subunit

CobT

Family

4,098

false

These proteins are CobT subunits of the aerobic cobalt chelatase (aerobic cobalamin biosynthesis pathway). Pseudomonas denitrificans CobT has been experimentally characterised [ , ]. Aerobic cobalt chelatase consists of three subunits, CobT, CobN ( ) and CobS ( ). Cobalamin (vitamin B12) can be complexed with metal via...

[ "GO:0009236" ]

[ "cobalamin biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF06213", "PIRSF031715", "TIGR01651" ]

[ "CobT", "Cob_chel_CobT", "CobT" ]

[ 4076, 3635, 2734 ]

3

[]

0

[]

0

[ "PUB00006361", "PUB00009664", "PUB00011188", "PUB00011189" ]

[ "8905078", "1429466", "1917840", "11469861" ]

[ "Cobalamin (coenzyme B12): synthesis and biological significance.", "Assay, purification, and characterization of cobaltochelatase, a unique complex enzyme catalyzing cobalt insertion in hydrogenobyrinic acid a,c-diamide during coenzyme B12 biosynthesis in Pseudomonas denitrificans.", "Genetic and sequence anal...

[ 1996, 1992, 1991, 2001 ]

4

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 4016, 8, 4, 70 ]

4

[]

0

true

Family

Cobalt chelatase, CobT subunit

CobT

9

IPR006540

6,540

Bacteriocin, lactococcin 972

Lactococcin_972

Family

894

false

These sequences represent bacteriocins related to lactococcin 972 [ ]. Members tend to be found in association with a seven transmembrane putative immunity protein.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09683", "TIGR01653" ]

[ "Lactococcin_972", "lactococcin_972" ]

[ 852, 513 ]

2

[ "GP" ]

[ "GenProp0809" ]

[ "GP:GenProp0809" ]

1

[ "2lgn" ]

1

[ "PUB00009668" ]

[ "10589723" ]

[ "Synthesis of lactococcin 972, a bacteriocin produced by Lactococcus lactis IPLA 972, depends on the expression of a plasmid-encoded bicistronic operon." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 873, 18, 3 ]

3

[]

0

true

Family

Bacteriocin, lactococcin 972

Lactococcin_972

6

IPR006541

6,541

Bacteriocin-associated integral membrane protein

Bacteriocin_ass

Family

1,346

false

These sequences represent a family of integral membrane proteins, most of which are about 650 residues in size and predicted to span the membrane seven times. Nearly half of the members of this family are found in association with a member of the lactococcin 972 family of bacteriocins ( ) [ ]. Others may be associated ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF07242", "TIGR01654" ]

[ "DUF1430", "bact_immun_7tm" ]

[ 1194, 870 ]

2

[ "GP" ]

[ "GenProp0809" ]

[ "GP:GenProp0809" ]

1

[]

0

[ "PUB00009668" ]

[ "10589723" ]

[ "Synthesis of lactococcin 972, a bacteriocin produced by Lactococcus lactis IPLA 972, depends on the expression of a plasmid-encoded bicistronic operon." ]

[ 1999 ]

1

[]

[ "IPR016976" ]

0

1

0

[ "Bacteria", "metagenomes" ]

[ 1342, 4 ]

2

[]

0

true

Family

Bacteriocin-associated integral membrane protein

Bacteriocin_ass

4

IPR006542

6,542

Protein of unknown function DUF1093

DUF1093

Family

3,417

false

These are a family of small (about 115 amino acids) uncharacterised proteins with N-terminal signal sequences, found predominantly in Gram-positive organisms. Most genomes that have any members of this family have at least two members. This entry includes YxeA from Bacillus subtilis, which gene is located in operon enc...

[]

0

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF06486", "PTHR36433", "TIGR01655" ]

[ "DUF1093", "", "yxeA_fam" ]

[ 3127, 2871, 3117 ]

3

[]

0

[ "2k5q", "2k5w", "3npp" ]

3

[ "PUB00062417" ]

[ "15289557" ]

[ "Characterization of the Bacillus subtilis YxdJ response regulator as the inducer of expression for the cognate ABC transporter YxdLM." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Cylicostephanus goldi", "metagenomes" ]

[ 3405, 7, 1, 4 ]

4

[]

0

true

Family

Protein of unknown function DUF1093

DUF1093

3

IPR006543

6,543

Histidinol-phosphate phosphatase

Histidinol-phos

Domain

18,118

false

This is a group of authentic histidinol-phosphate phosphatases which are sometimes found as stand-alone entities and sometimes as fusions with imidazoleglycerol-phosphate dehydratase. Additionally, a family of proteins including YaeD from Escherichia coli and various other proteins are closely related but may not have ...

[ "GO:0016791" ]

[ "phosphatase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01656" ]

[ "Histidinol-ppas" ]

[ 18118 ]

1

[ "EC", "EC", "EC" ]

[ "3.1.3", "3.1.3.15", "4.2.1.19" ]

[ "EC:3.1.3", "EC:3.1.3.15", "EC:4.2.1.19" ]

3

[ "2fpr", "2fps", "2fpu", "2fpw", "2fpx", "2gmw", "2o2x", "3esq", "3esr", "3l1u", "3l1v", "3l8e", "3l8f", "3l8g", "3l8h", "4pnh" ]

16

[]

0

[ "IPR006549" ]

[ "IPR005954" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 54, 17690, 99, 275 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Histidinol-phosphate phosphatase

Histidinol-phos

5

IPR006544

6,544

P-type ATPase, subfamily V

P-type_TPase_V

Family

18,168

false

This entry includes P-type ATPases from eukaryotes that form a different clade, designated subfamily V (P5-ATPases) [ ]. P-type ATPases use ATP for intracellular cation homeostasis and are required for proper lysosomal and mitochondria maintenance [ , ], also playing a role in the maintenance of neuronal integrity [ ]....

[ "GO:0140358", "GO:0016020" ]

[ "P-type transmembrane transporter activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PANTHER", "NCBIFAM" ]

[ "PTHR45630", "TIGR01657" ]

[ "", "P-ATPase-V" ]

[ 18163, 12908 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-936837", "R-HSA-936837", "R-MMU-936837", "R-SCE-936837", "R-SPO-936837" ]

[ "REACTOME:R-CEL-936837", "REACTOME:R-HSA-936837", "REACTOME:R-MMU-936837", "REACTOME:R-SCE-936837", "REACTOME:R-SPO-936837" ]

5

[ "6xmp", "6xmq", "6xms", "6xmt", "6xmu", "7fjm", "7fjp", "7fjq", "7m5v", "7m5x", "7m5y", "7n70", "7n72", "7n73", "7n74", "7n75", "7n76", "7n77", "7n78", "7op1", "7op3", "7op5", "7op8", "7vpi", "7vpj", "7vpk", "7vpl", "8iek", "8iel", "8iem", "8ien", "8ieo"...

44

[ "PUB00009616", "PUB00020603", "PUB00020604", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00094240", "PUB00094241", "PUB00096637", "PUB00101910", "PUB00101911", "PUB00151055", "PUB00151056", "PUB00151057", "PUB00151058", "PUB00151059", "PUB00151060", "PUB001510...

[ "9419228", "15473999", "15078220", "20450191", "18937357", "1385979", "9741106", "19762559", "27278822", "32973005", "33310703", "34663092", "34715013", "34172751", "34715014", "22918956", "32353073", "31996848", "22745129", "37264943", "37838176" ]

[ "Evolution of substrate specificities in the P-type ATPase superfamily.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "Regulation and isoform function of the V-ATPases...

[ 1998, 2004, 2004, 2010, 2008, 1992, 1998, 2010, 2016, 2020, 2021, 2021, 2021, 2021, 2021, 2012, 2020, 2020, 2012, 2023, 2023 ]

21

[ "IPR001757" ]

[ "IPR047820", "IPR047821" ]

1

2

0

[ "Actinomycetes", "Catovirus CTV1", "Eukaryota", "bird metagenome" ]

[ 2, 1, 18163, 2 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 8, 14, 14, 27, 20, 2, 5, 26, 2, 3, 20 ]

12

true

Family

P-type ATPase, subfamily V

P-type_TPase_V

5

IPR006545

6,545

EYA domain

EYA_dom

Domain

8,331

false

The Eyes absent proteins are members of a conserved regulatory network implicated in the development of the eye, muscle, kidney and ear. Eyes absent is a nuclear transcription factor, acting through interaction with homeodomain-containing Sine oculis (also known as Six) proteins. Eyes absent is also a protein tyrosine ...

[ "GO:0007275" ]

[ "multicellular organism development" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR01658" ]

[ "EYA-cons_domain" ]

[ 8331 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.48", "R-BTA-5693565", "R-DME-5693565", "R-HSA-5693565", "R-HSA-9830674", "R-MMU-5693565" ]

[ "EC:3.1.3.48", "REACTOME:R-BTA-5693565", "REACTOME:R-DME-5693565", "REACTOME:R-HSA-5693565", "REACTOME:R-HSA-9830674", "REACTOME:R-MMU-5693565" ]

6

[ "3geb", "3hb0", "3hb1", "4egc", "5zma", "7f8g", "7f8h", "9n0y" ]

8

[ "PUB00014199", "PUB00014200", "PUB00088225" ]

[ "14628053", "14628052", "10835393" ]

[ "The transcription factor Eyes absent is a protein tyrosine phosphatase.", "Eyes absent represents a class of protein tyrosine phosphatases.", "Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain." ]

[ 2003, 2003, 2000 ]

3

[]

[ "IPR042577" ]

0

1

0

[ "Eukaryota" ]

[ 8331 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 97, 2, 27, 16, 3, 29, 7 ]

8

true

Domain

EYA domain

EYA_dom

6

IPR006546

6,546

Sex-lethal splicing factor

Sxl

Family

147

false

These sequences describe the sex-lethal family of splicing factors found in Dipteran insects. The sex-lethal phenotype, however, may be limited to the Melanogasters and closely related species [ ]. In Drosophila the protein acts as an inhibitor of splicing. This subfamily is most closely related to the ELAV/HUD subfami...

[ "GO:0003723", "GO:0000380", "GO:0007530" ]

[ "RNA binding", "alternative mRNA splicing, via spliceosome", "sex determination" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01659" ]

[ "sex-lethal" ]

[ 147 ]

1

[]

0

[]

0

[ "PUB00009671", "PUB00033013", "PUB00083875", "PUB00083876", "PUB00083879" ]

[ "10648226", "10220389", "3144435", "12966139", "9592147" ]

[ "Structure, function and evolution of sex-determining systems in Dipteran insects.", "Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal.", "Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA...

[ 2000, 1999, 1988, 2003, 1998 ]

5

[ "IPR002343" ]

[]

1

0

1

[ "Cyclorrhapha" ]

[ 147 ]

1

[ "Drosophila melanogaster" ]

[ 7 ]

1

true

Family

Sex-lethal splicing factor

Sxl

4

IPR006547

6,547

Nitrate reductase, beta subunit

NO3_Rdtase_bsu

Family

7,609

false

The nitrate reductase enzyme complex allows bacteria to use nitrate as an electron acceptor during anaerobic growth. The enzyme complex consists of a tetramer that has an alpha, beta and 2 gamma subunits. The alpha and beta subunits have catalytic activity and the gamma subunits attach the enzyme to the membrane and ar...

[ "GO:0008940", "GO:0042126", "GO:0009325" ]

[ "nitrate reductase activity", "nitrate metabolic process", "nitrate reductase complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR01660", "cd10557" ]

[ "narH", "NarH_beta-like" ]

[ 7606, 6012 ]

2

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC" ]

[ "1.7.5.1", "GenProp0636", "GenProp1122", "GenProp1329", "GenProp1474", "GenProp1583", "GenProp1676", "PWY-6748" ]

[ "EC:1.7.5.1", "GP:GenProp0636", "GP:GenProp1122", "GP:GenProp1329", "GP:GenProp1474", "GP:GenProp1583", "GP:GenProp1676", "METACYC:PWY-6748" ]

8

[ "1q16", "1r27", "1siw", "1y4z", "1y5i", "1y5l", "1y5n", "3egw", "3ir5", "3ir6", "3ir7" ]

11

[ "PUB00008262", "PUB00009746" ]

[ "2233673", "2674654" ]

[ "Nitrate reductases of Escherichia coli: sequence of the second nitrate reductase and comparison with that encoded by the narGHJI operon.", "Nitrate reductase of Escherichia coli: completion of the nucleotide sequence of the nar operon and reassessment of the role of the alpha and beta subunits in iron binding an...

[ 1990, 1989 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 25, 7509, 4, 71 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Nitrate reductase, beta subunit

NO3_Rdtase_bsu

1

IPR006548

6,548

Splicing factor ELAV/Hu

ELAD_HU_SF

Family

8,198

false

These sequences represent the ELAV/Hu subfamily of splicing factors found in metazoa. ELAV stands for the Drosophila Embryonic lethal abnormalvisual protein [ ]. ELAV-like splicing factors are also known in human as HuB (ELAV-like protein 2), HuC (ELAV-like protein 3, HuD (LAV-like protein 4) and HuR (ELAV-like protein...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01661" ]

[ "ELAV_HUD_SF" ]

[ 8198 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-450520", "R-HSA-450520", "R-MMU-450520", "R-RNO-450520", "R-XTR-450520" ]

[ "REACTOME:R-DME-450520", "REACTOME:R-HSA-450520", "REACTOME:R-MMU-450520", "REACTOME:R-RNO-450520", "REACTOME:R-XTR-450520" ]

5

[ "1fnx", "1fxl", "1g2e", "4ed5", "4egl" ]

5

[ "PUB00000859", "PUB00009747", "PUB00084953" ]

[ "1655278", "3144044", "22139917" ]

[ "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.", "The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs.", "Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternati...

[ 1991, 1988, 2012 ]

3

[ "IPR002343" ]

[]

1

0

1

[ "Eukaryota" ]

[ 8198 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 45, 12, 15, 23, 22 ]

6

true

Family

Splicing factor ELAV/Hu

ELAD_HU_SF

9

IPR006549

6,549

HAD-superfamily hydrolase,subfamily IIIA

HAD-SF_hydro_IIIA

Domain

35,266

false

This group of proteins is a part of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. The Class III subfamilies are characterised by the lack of any domains located either between the first and second conserved catalytic motifs (as in the Class I subfamilies) or between the second and thi...

[]

0

[ "NCBIFAM" ]

[ "TIGR01662" ]

[ "HAD-SF-IIIA" ]

[ 35266 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "3.1.3", "R-HSA-5649702", "R-MMU-5649702" ]

[ "EC:3.1.3", "REACTOME:R-HSA-5649702", "REACTOME:R-MMU-5649702" ]

3

[ "1j8d", "1k1e", "1yj5", "2fpr", "2fps", "2fpu", "2fpw", "2fpx", "2gmw", "2hoq", "2o2x", "2p9j", "3e81", "3e84", "3e8m", "3esq", "3esr", "3l1u", "3l1v", "3l8e", "3l8f", "3l8g", "3l8h", "3n1u", "3u7e", "3u7f", "3u7g", "3u7h", "3zvl", "3zvm", "3zvn", "4hgo"...

40

[ "PUB00003337", "PUB00009589", "PUB00009674" ]

[ "7966317", "11601995", "3007936" ]

[ "Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search.", "MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases.", "Gene structur...

[ 1994, 2001, 1986 ]

3

[]

[ "IPR006543", "IPR006551" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 202, 29076, 5381, 103, 504 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 10, 1, 3, 2, 2, 6, 4, 1, 3, 4, 2, 11 ]

12

true

Domain

HAD-superfamily hydrolase,subfamily IIIA

HAD-SF_hydro_IIIA

6

IPR006550

6,550

Bifunctional polynucleotide phosphatase/kinase PNKP

PNKP

Family

966

false

This entry includes bifunctional polynucleotide phosphatase/kinase PNKP from animals. PNKP plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. It has been shown that the DNA 3'-phosphatase activity of PNKP takes precede...

[ "GO:0046403", "GO:0046404", "GO:0006281" ]

[ "polynucleotide 3'-phosphatase activity", "ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "DNA repair" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01663" ]

[ "PNK-3'Pase" ]

[ 966 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5649702", "R-MMU-5649702" ]

[ "REACTOME:R-HSA-5649702", "REACTOME:R-MMU-5649702" ]

2

[ "1yj5", "3u7e", "3u7f", "3u7g", "3u7h", "3zvl", "3zvm", "3zvn" ]

8

[ "PUB00092581", "PUB00092582" ]

[ "22210862", "16648365" ]

[ "Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair.", "The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity in repair of single strand breaks." ]

[ 2012, 2006 ]

2

[ "IPR013954" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 966 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 5, 3, 4 ]

5

true

Family

Bifunctional polynucleotide phosphatase/kinase PNKP

PNKP

9

IPR006553

6,553

Leucine-rich repeat, cysteine-containing subtype

Leu-rich_rpt_Cys-con_subtyp

Repeat

76,481

false

Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape [ ]. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [ , ].Proteins containing LR...

[]

0

[ "SMART" ]

[ "SM00367" ]

[ "LRR_CC" ]

[ 76481 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-8951664", "R-BTA-917937", "R-BTA-983168", "R-CEL-8951664", "R-CEL-983168", "R-CFA-8951664", "R-CFA-983168", "R-DRE-8854050", "R-DRE-8951664", "R-DRE-917937", "R-DRE-983168", "R-HSA-168928", "R-HSA-174178", "R-HSA-187577", "R-HSA-3214842", "R-HSA-390471", "R-HSA-5689880", "R-...

[ "REACTOME:R-BTA-8951664", "REACTOME:R-BTA-917937", "REACTOME:R-BTA-983168", "REACTOME:R-CEL-8951664", "REACTOME:R-CEL-983168", "REACTOME:R-CFA-8951664", "REACTOME:R-CFA-983168", "REACTOME:R-DRE-8854050", "REACTOME:R-DRE-8951664", "REACTOME:R-DRE-917937", "REACTOME:R-DRE-983168", "REACTOME:R-HS...

43

[ "1a4y", "1dfj", "1fqv", "1fs2", "1z7x", "2ass", "2ast", "2bex", "2bnh", "2p1m", "2p1n", "2p1o", "2p1p", "2p1q", "2q4g", "3c6n", "3c6o", "3c6p", "4peq", "4per", "4q62", "4r5d", "4r6g", "5hyw", "5hzg", "5jh5", "5zb2", "6bro", "6brp", "6brq", "6o60", "6vcd"...

63

[ "PUB00001625", "PUB00001898", "PUB00007147", "PUB00007148", "PUB00017058", "PUB00094376" ]

[ "1657640", "2176636", "11751054", "11967365", "14747988", "21606681" ]

[ "A leucine-rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a beta-sheet structure.", "slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.", "The leucine-rich repeat as a protein reco...

[ 1991, 1990, 2001, 2002, 2004, 2011 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 5, 1149, 75067, 157, 103 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 217, 6, 135, 30, 68, 50, 4, 158, 90, 4, 2, 286 ]

12

true

Repeat

Leucine-rich repeat, cysteine-containing subtype

Leu-rich_rpt_Cys-con_subtyp

3

IPR006554

6,554

Helicase-like, DEXD box c2 type

Helicase-like_DEXD_c2

Domain

22,538

false

This domain of unknown function is found in the Xeroderma pigmentosum group D (XPD) proteins which belong to a family of ATP-dependent helicases characterised by a 'D-E-A-H' motif. This resembles the 'D-E-A-D-box' of other known helicases, which represents a special version of the B motif of ATP-binding proteins. In XP...

[ "GO:0003678", "GO:0016818" ]

[ "DNA helicase activity", "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" ]

[ "molecular_function", "molecular_function" ]

2

[ "SMART" ]

[ "SM00488" ]

[ "DEXDc2" ]

[ 22538 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "5.6.2.3", "R-BTA-113418", "R-BTA-5696395", "R-BTA-5696400", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-72086", "R-BTA-73762", "R-BTA-73772", "R-BTA-73776", "R-BTA-73779", "R-BTA-73863", "R-BTA-75953", "R-BTA-75955", "R-BTA-76042", ...

[ "EC:5.6.2.3", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5696395", "REACTOME:R-BTA-5696400", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-72086", "REACTOME:R-BTA-73762", "REACTOME:R-BTA-73772", ...

143

[ "2vl7", "2vsf", "3crv", "3crw", "4a15", "5fmf", "5h8c", "5h8w", "5ivw", "5iy6", "5iy7", "5iy8", "5iy9", "5of4", "5oqj", "5oqm", "5sva", "6fwr", "6fws", "6gym", "6nmi", "6o9l", "6o9m", "6ro4", "7ad8", "7egb", "7egc", "7ena", "7enc", "7k01", "7k04", "7lbm"...

80

[]

0

[ "IPR010614" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Sulfolobus virus Kamchatka 1", "unclassified sequences" ]

[ 957, 5916, 15575, 1, 89 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 37, 4, 24, 13, 1, 40, 14, 2, 10, 16, 2, 2, 33 ]

13

true

Domain

Helicase-like, DEXD box c2 type

Helicase-like_DEXD_c2

9

IPR006560

6,560

AWS domain

AWS_dom

Domain

15,473

false

This domain, Associated With SET (AWS), whose specific function is still unknown, is found in a group of histone-lysine N-methyltransferases and similar eukaryotic proteins, including Histone-lysine N-methyltransferase, H3 lysine-36 specific from humans (H3-K36-HMTase or Nsd1). Nsd1 is a transcriptional intermediary fa...

[ "GO:0042054", "GO:0005634" ]

[ "histone methyltransferase activity", "nucleus" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PROFILE", "SMART" ]

[ "PF17907", "PS51215", "SM00570" ]

[ "AWS", "AWS", "AWS" ]

[ 13230, 15283, 13828 ]

3

[ "EC", "EC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1", "2.1.1.359", "PDOC51215", "R-HSA-3214841", "R-HSA-5693565", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-69473", "R-MMU-3214841", "R-MMU-5693565", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-69473", "R-PFA-3214841", "R-SCE-3214841", "R-SCE-5693565", "R-SPO-3214841", "R-SPO-569356...

[ "EC:2.1.1", "EC:2.1.1.359", "PROSITEDOC:PDOC51215", "REACTOME:R-HSA-3214841", "REACTOME:R-HSA-5693565", "REACTOME:R-HSA-5693571", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-69473", "REACTOME:R-MMU-3214841", "REACTOME:R-MMU-5693565", "REACTOME:R-MMU-5693571", "REACTOME:R-MMU-5693607", "REACTOM...

18

[ "3ooi", "3ope", "4fmu", "4h12", "4ynm", "4ynp", "4ypa", "4ype", "4ypu", "5jjy", "5jlb", "5jle", "5lss", "5lsu", "5lsx", "5lsy", "5lsz", "5lt6", "5lt7", "5lt8", "5upd", "5v21", "5v22", "6ago", "6cen", "6ine", "6j9j", "6kqp", "6kqq", "6nzo", "6px3", "6vdb"...

62

[ "PUB00055387", "PUB00101938" ]

[ "21196496", "11896389" ]

[ "The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation.", "Haploinsufficiency of NSD1 causes Sotos syndrome." ]

[ 2011, 2002 ]

2

[]

0

null

[ "Eukaryota", "Succiniclasticum ruminis" ]

[ 15472, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 29, 4, 40, 5, 27, 12, 2, 12, 21, 1, 1, 36 ]

12

true

Domain

AWS domain

AWS_dom

7

IPR006561

6,561

DZF domain

DZF_dom

Domain

9,256

false

This entry represents the DZF domain, which is found exclusively in metazoa. The DZF domain (domain associated with zinc fingers) is a dimerisation domain found in [ , , ]: Interleukin enhancer-binding factor 3 (also known as Nuclear factor of activated T-cells 90 kDa, NF90, DRBP76 or NFAR), contains two double-strande...

[]

0

[ "PROFILE", "SMART" ]

[ "PS51703", "SM00572" ]

[ "DZF", "DZF" ]

[ 9238, 8572 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6798695", "R-DME-9833482", "R-DRE-6798695", "R-DRE-9833482", "R-HSA-6798695", "R-HSA-9762293", "R-HSA-9833482", "R-MMU-6798695", "R-MMU-9762293", "R-MMU-9833482", "R-RNO-6798695", "R-RNO-9833482", "R-XTR-6798695", "R-XTR-9762293", "R-XTR-9833482" ]

[ "REACTOME:R-DME-6798695", "REACTOME:R-DME-9833482", "REACTOME:R-DRE-6798695", "REACTOME:R-DRE-9833482", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9762293", "REACTOME:R-HSA-9833482", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-9762293", "REACTOME:R-MMU-9833482", "REACTOME:R-RNO-6798695", "REACTOM...

15

[ "4at7", "4at8", "4at9", "4atb", "5dv7" ]

5

[ "PUB00011448", "PUB00063988", "PUB00072569" ]

[ "11779830", "22833610", "11438540" ]

[ "Systematic identification of novel protein domain families associated with nuclear functions.", "NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltransferase fold.", "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded R...

[ 2002, 2012, 2001 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halobium salinum", "bird metagenome" ]

[ 5, 9249, 1, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 40, 5, 34, 21, 29 ]

6

true

Domain

DZF domain

DZF_dom

1

IPR006563

6,563

POX domain

POX_dom

Domain

8,199

false

This domain in found exclusively in plant proteins, associated with homeobox domain which may suggest these proteins are homeodomain transcription factors. Proteins containing this domain include BEL1-like homeodomain protein 1 (BLH1) from Arabidopsis thaliana. BLH1 interacts with KNAT2 and KNAT5 [ ] and affects plant ...

[]

0

[ "PFAM", "SMART" ]

[ "PF07526", "SM00574" ]

[ "POX", "POX" ]

[ 8180, 7794 ]

2

[]

0

[]

0

[ "PUB00066806", "PUB00066807" ]

[ "17873098", "20371112" ]

[ "The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act redundantly to regulate KNOX expression spatially in leaf margins.", "Plant development: a TALE story." ]

[ 2007, 2010 ]

2

[]

0

null

[ "Embryophyta" ]

[ 8199 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 63, 54, 74 ]

3

true

Domain

POX domain

POX_dom

4

IPR006564

6,564

Zinc finger, PMZ-type

Znf_PMZ

Domain

37,143

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "SMART" ]

[ "SM00575" ]

[ "ZnF_PMZ" ]

[ 37143 ]

1

[]

0

[]

0

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001 ]

6

[ "IPR007527" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota" ]

[ 7, 17, 37119 ]

3

[ "Arabidopsis thaliana", "Homo sapiens", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 267, 3, 452, 86 ]

4

true

Domain

Zinc finger, PMZ-type

Znf_PMZ

4

IPR006565

6,565

Bromodomain associated domain

BTP

Domain

10,603

false

This domain is found in eukaryotic bromodomain containing transcription factors and PHD domain containing proteins ( ). This domain has a histone-like fold and is predicted to bind DNA [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF07524", "SM00576" ]

[ "Bromo_TP", "BTP" ]

[ 10544, 7561 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-6807505", "R-DME-6807505", "R-DRE-6807505", "R-GGA-6807505", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-3214847", "R-HSA-674695", "R-HSA-6804756", "R-HSA-6807505", "R-HSA-73776", "R-HSA-73779", "R-HSA-75953", "R-HSA-76042", "R-MMU-674695", "R-MMU-6804756", "R-MMU...

[ "REACTOME:R-BTA-6807505", "REACTOME:R-DME-6807505", "REACTOME:R-DRE-6807505", "REACTOME:R-GGA-6807505", "REACTOME:R-HSA-167161", "REACTOME:R-HSA-167162", "REACTOME:R-HSA-167172", "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-674695", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-6807505", "REACTOME:R-...

23

[ "4wv4", "5fur", "6mzc", "6mzd", "6mzl", "6mzm", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egf", "7egg", "7egh", "7egi", "7egj", "7ena", "7enc", "7ktr", "7kts", "8gxq", "8gxs", "8h7g", "8wak", "8wal", "8wan", "8wao", "8wap"...

35

[ "PUB00011448" ]

[ "11779830" ]

[ "Systematic identification of novel protein domain families associated with nuclear functions." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 10603 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 19, 4, 3, 9, 14, 10, 3, 8, 11, 1, 2, 13 ]

12

true

Domain

Bromodomain associated domain

BTP

1

IPR006566

6,566

FBD domain

FBD

Domain

20,772

false

This domain is found at the C-terminal of F-box domain containing proteins from plants. Its precise function is unknown, but it is thought to be associated with nuclear processes [ ]. Proteins in this entry are involved in the ubiquitin-proteasome pathway. They function as components of SCF (SKP1-CUL1-F-box protein) E3...

[]

0

[ "PFAM", "SMART" ]

[ "PF08387", "SM00579" ]

[ "FBD", "FBD" ]

[ 16784, 14419 ]

2

[]

0

[]

0

[ "PUB00011448", "PUB00153716" ]

[ "11779830", "33098089" ]

[ "Systematic identification of novel protein domain families associated with nuclear functions.", "AtMIF1 increases seed oil content by attenuating GL2 inhibition." ]

[ 2002, 2021 ]

2

[]

0

null

[ "Magnoliopsida", "Pseudomonadati" ]

[ 20770, 2 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 708, 108, 29 ]

3

true

Domain

FBD domain

FBD

6

IPR006568

6,568

PSP, proline-rich

PSP_pro-rich

Domain

7,522

false

PSP is a proline-rich domain of unknown function found in spliceosome associated proteins.

[]

0

[ "PFAM", "SMART" ]

[ "PF04046", "SM00581" ]

[ "PSP", "PSP" ]

[ 7505, 7284 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-9930044", "R-HSA-72163", "R-HSA-72165", "R-HSA-9843970", "R-HSA-9930044", "R-MMU-72163", "R-MMU-72165", "R-MMU-9930044" ]

[ "REACTOME:R-DME-9930044", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72165", "REACTOME:R-HSA-9843970", "REACTOME:R-HSA-9930044", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72165", "REACTOME:R-MMU-9930044" ]

8

[ "5gm6", "5lsb", "5lsl", "5lxr", "5lxy", "5nrl", "5z56", "5z57", "5z58", "5zwm", "5zwo", "6ah0", "6ahd", "6ff4", "6ff7", "6g90", "6qx9", "6y50", "6y53", "6y5q", "7abg", "7abh", "7abi", "7dco", "7dvq", "7evo", "7onb", "7oqb", "7oqe", "7q3l", "7q4o", "7q4p"...

60

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "bird metagenome" ]

[ 4, 7517, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 23, 4, 4, 2, 8, 3, 1, 5, 9, 1, 1, 19 ]

12

true

Domain

PSP, proline-rich

PSP_pro-rich

1

IPR006569

6,569

CID domain

CID_dom

Domain

32,899

false

The C-terminal domain (CTD) of the large subunit of RNA polymerase II is a platform for mRNA processing factors and links gene transcription to mRNA capping, splicing and polyadenylation. CTD recognition is dependent on the phosphorylation state of the CTD itself, which varies during the course of transcription but has...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF04818", "PS51391", "SM00582" ]

[ "CID", "CID", "RPR" ]

[ 29257, 32360, 26408 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6807505", "R-CEL-6807505", "R-CEL-72187", "R-CEL-72203", "R-CEL-73856", "R-CEL-77595", "R-HSA-6807505", "R-HSA-72163", "R-HSA-72187", "R-HSA-72203", "R-HSA-73856", "R-HSA-77595", "R-MMU-6807505", "R-MMU-72163", "R-MMU-72187", "R-MMU-72203", "R-MMU-73856", "R-MMU-77595", "R...

[ "REACTOME:R-BTA-6807505", "REACTOME:R-CEL-6807505", "REACTOME:R-CEL-72187", "REACTOME:R-CEL-72203", "REACTOME:R-CEL-73856", "REACTOME:R-CEL-77595", "REACTOME:R-HSA-6807505", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72187", "REACTOME:R-HSA-72203", "REACTOME:R-HSA-73856", "REACTOME:R-HSA-77595", ...

20

[ "1sz9", "1sza", "2bf0", "2diw", "2km4", "2l0i", "2lo6", "2mow", "3clj", "3d9i", "3d9j", "3d9k", "3d9l", "3d9m", "3d9n", "3d9o", "3d9p", "4flb", "4fu3", "4hfg", "4jxt", "4nac", "4q94", "4q96", "5ce7", "5lvf", "5m9d", "5mdt", "5woz", "6gc3", "6o3w", "6o3x"...

37

[ "PUB00031251", "PUB00039629" ]

[ "15241417", "15665873" ]

[ "Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA-processing factors.", "Key features of the interaction between Pcf11 CID and RNA polymerase II CTD." ]

[ 2004, 2005 ]

2

[]

[ "IPR024638", "IPR047415", "IPR047882", "IPR047883", "IPR047884", "IPR047885" ]

0

6

0

[ "Bacteria", "Eukaryota" ]

[ 7, 32892 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 60, 10, 30, 21, 25, 20, 7, 36, 34, 3, 5, 161 ]

12

true

Domain

CID domain

CID_dom

8

IPR006570

6,570

SPK domain

SPK_dom

Domain

811

false

SPK is a domain of unknown function that is found in some SET and PHD domain-containing proteins and protein kinases.

[]

0

[ "PFAM", "SMART" ]

[ "PF04435", "SM00583" ]

[ "SPK", "SPK" ]

[ 808, 515 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Algibacter luteus", "Rhabditidae" ]

[ 1, 810 ]

2

[ "Caenorhabditis elegans" ]

[ 41 ]

1

true

Domain

SPK domain

SPK_dom

8

IPR006571

6,571

TLDc domain

TLDc_dom

Domain

34,070

false

The Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic (TLDc) domain is present in all eukaryotes, and its primary sequence is highly conserved among species. The TLDc domain is present in several proteins that share a protective function against oxidative stress (OS). The TLDc domain alone is able to confer o...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF07534", "PS51886", "SM00584" ]

[ "TLD", "TLDC", "TLDc" ]

[ 33704, 31343, 24695 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8854214", "R-HSA-9909505", "R-MMU-8854214", "R-MMU-9909505" ]

[ "REACTOME:R-HSA-8854214", "REACTOME:R-HSA-9909505", "REACTOME:R-MMU-8854214", "REACTOME:R-MMU-9909505" ]

4

[ "4acj", "6r82", "7fde", "7obp", "7u4t", "7u8o", "7une", "7unf", "7uzg", "7uzi", "7uzj", "7uzk", "8ar6", "8ar9" ]

14

[ "PUB00059585", "PUB00094779", "PUB00094780", "PUB00094781" ]

[ "22434723", "20567517", "28707022", "26668325" ]

[ "Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish.", "The Anopheles gambiae oxidation resistance 1 (OXR1) gene regulates expression of enzymes that detoxify reactive oxygen species.", "TLDc proteins: new players in the oxidative stress response and neurological disease.", ...

[ 2012, 2010, 2017, 2016 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Pandoravirus", "marine metagenome" ]

[ 46, 34020, 2, 2 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 25, 15, 44, 33, 26, 20, 2, 19, 33, 2, 2, 36 ]

12

true

Domain

TLDc domain

TLDc_dom

1

IPR006572

6,572

Zinc finger, DBF-type

Znf_DBF

Domain

4,747

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[ "GO:0003676", "GO:0008270" ]

[ "nucleic acid binding", "zinc ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PROFILE", "SMART" ]

[ "PF07535", "PS51265", "SM00586" ]

[ "zf-DBF", "ZF_DBF4", "ZnF_DBF" ]

[ 4537, 4694, 4333 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-176187", "R-DME-68962", "R-HSA-176187", "R-HSA-68962", "R-MMU-176187", "R-MMU-68962", "R-SCE-176187", "R-SCE-68962", "R-SPO-176187", "R-SPO-68962", "R-XTR-68962" ]

[ "REACTOME:R-DME-176187", "REACTOME:R-DME-68962", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-68962", "REACTOME:R-MMU-176187", "REACTOME:R-MMU-68962", "REACTOME:R-SCE-176187", "REACTOME:R-SCE-68962", "REACTOME:R-SPO-176187", "REACTOME:R-SPO-68962", "REACTOME:R-XTR-68962" ]

11

[ "4f99", "4f9a", "4f9b", "4f9c", "6ya6", "6ya7", "6ya8", "7p5z", "7pt6", "7pt7", "7v3v" ]

11

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00043725", "PUB00043726", "PUB00043727", "PUB00043728" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890", "8984634", "14643426", "8943332", "8066465" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001, 1996, 2003, 1996, 1994 ]

10

[]

0

null

[ "Candidatus Woesebacteria bacterium GW2011_GWA1_39_8", "Eukaryota" ]

[ 1, 4746 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 5, 1, 11, 6, 1, 4, 1, 2 ]

8

true

Domain

Zinc finger, DBF-type

Znf_DBF

9

IPR006573

6,573

Neuralized homology repeat (NHR) domain

NHR_dom

Domain

8,016

false

The neuralized homology repeat (NHR) domain is a module of ~160 amino acids, which has been identified as a tandem repeat in drosophila neuralized, a protein involved in development of the central and peripheral nervous system [ ]. Several other fly, worm, and mammalian neuralized-like proteins were found to contain be...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF07177", "PS51065", "SM00588" ]

[ "Neuralized", "NHR", "NEUZ" ]

[ 7758, 7715, 7171 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC51065", "R-HSA-2122948", "R-HSA-2644606", "R-HSA-2691232", "R-HSA-2894862", "R-HSA-2979096", "R-HSA-8951664", "R-HSA-9013507", "R-MMU-8951664" ]

[ "PROSITEDOC:PDOC51065", "REACTOME:R-HSA-2122948", "REACTOME:R-HSA-2644606", "REACTOME:R-HSA-2691232", "REACTOME:R-HSA-2894862", "REACTOME:R-HSA-2979096", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-9013507", "REACTOME:R-MMU-8951664" ]

9

[ "2e63", "2yue", "4kg0" ]

3

[ "PUB00007973", "PUB00011448", "PUB00018520", "PUB00018521" ]

[ "11731489", "11779830", "9519875", "11696324" ]

[ "Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution.", "Systematic identification of novel protein domain families associated with nuclear functions.", "Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant as...

[ 2001, 2002, 1998, 2001 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 2, 131, 7880, 3 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 14, 7, 16, 18, 24 ]

6

true

Domain

Neuralized homology repeat (NHR) domain

NHR_dom

2

IPR006574

6,574

SPRY-associated

PRY

Domain

63,274

false

PRY is a 50-60 amino acids domain associated with SPRY domains, adjacent to its N-terminal. The SPRY domain ( ) is a protein-protein interaction module involved in many important signaling pathways [ , ]. Distant homologues are domains in butyrophilin/marenostrin/pyrin, evolutionarily more ancient than SPRY/B30.2 count...

[]

0

[ "PFAM", "SMART" ]

[ "PF13765", "SM00589" ]

[ "PRY", "PRY" ]

[ 61908, 61526 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-3134975", "R-BTA-9755511", "R-BTA-983168", "R-HSA-1169408", "R-HSA-168928", "R-HSA-1834941", "R-HSA-3134975", "R-HSA-3232142", "R-HSA-445355", "R-HSA-5656169", "R-HSA-5689896", "R-HSA-844456", "R-HSA-877300", "R-HSA-8851680", "R-HSA-8948751", "R-HSA-918233", "R-HSA-933541", ...

[ "REACTOME:R-BTA-3134975", "REACTOME:R-BTA-9755511", "REACTOME:R-BTA-983168", "REACTOME:R-HSA-1169408", "REACTOME:R-HSA-168928", "REACTOME:R-HSA-1834941", "REACTOME:R-HSA-3134975", "REACTOME:R-HSA-3232142", "REACTOME:R-HSA-445355", "REACTOME:R-HSA-5656169", "REACTOME:R-HSA-5689896", "REACTOME:R...

41

[ "2fbe", "2iwg", "2vok", "2wl1", "3kb5", "3zo0", "4b8e", "4cfg", "4cg4", "4n7i", "4n7u", "4v1p", "4wvm", "5hm7", "5lyg", "5lyk", "5zxk", "5zz3", "6flm", "6fln", "6ism", "6ita", "6j06", "6j0g", "6j0k", "6j0l", "6jbm", "6sjh", "6uma", "6umb", "7hla", "7hlb"...

221

[ "PUB00009560", "PUB00009682", "PUB00009683", "PUB00041714", "PUB00085899" ]

[ "9866204", "11331580", "1412709", "17189197", "23139046" ]

[ "B30.2-like domain proteins: update and new insights into a rapidly expanding family of proteins.", "The tripartite motif family identifies cell compartments.", "A novel zinc finger coiled-coil domain in a family of nuclear proteins.", "Structural basis for protein recognition by B30.2/SPRY domains.", "Stru...

[ 1998, 2001, 1992, 2006, 2013 ]

5

[]

0

null

[ "Eukaryota", "Nocardioides malaquae", "bird metagenome" ]

[ 63272, 1, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1007, 138, 89, 99 ]

4

true

Domain

SPRY-associated

PRY

4

IPR006575

6,575

RWD domain

RWD_dom

Domain

30,415

false

The RWD domain is a conserved region of about 110 amino acid residues, which has been identified in the mouse GCN2 eIF2alpha kinase and histidyl-tRNA synthetase and in presumed orthologues in other eukaryotic species from yeast to vertebrates. Additionally, it is also found in WD repeat containing proteins, yeast DEAD ...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF05773", "PS50908", "SM00591" ]

[ "RWD", "RWD", "RWD" ]

[ 27958, 27585, 22750 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC50908", "R-BTA-8866652", "R-BTA-983168", "R-DRE-983168", "R-GGA-9639288", "R-HSA-3065678", "R-HSA-8866652", "R-HSA-9629569", "R-HSA-9633012", "R-HSA-9639288", "R-HSA-983168", "R-MMU-3065678", "R-MMU-8866652", "R-MMU-9629569", "R-MMU-9639288", "R-MMU-983168", "R-RNO-9629569", "...

[ "PROSITEDOC:PDOC50908", "REACTOME:R-BTA-8866652", "REACTOME:R-BTA-983168", "REACTOME:R-DRE-983168", "REACTOME:R-GGA-9639288", "REACTOME:R-HSA-3065678", "REACTOME:R-HSA-8866652", "REACTOME:R-HSA-9629569", "REACTOME:R-HSA-9633012", "REACTOME:R-HSA-9639288", "REACTOME:R-HSA-983168", "REACTOME:R-M...

18

[ "1ukx", "2daw", "2dax", "2day", "2dmf", "2ebk", "2ebm", "2yz0", "4y1l", "6bqi", "6u1l", "6u1o", "7e2k", "7e2m", "7uhy", "8adl", "8ae6", "8t7t", "9bf3", "9f58", "9h4q", "9h5k", "9lvj", "9lvk", "9lwf", "9oti" ]

26

[ "PUB00011448" ]

[ "11779830" ]

[ "Systematic identification of novel protein domain families associated with nuclear functions." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4, 30403, 8 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 23, 6, 31, 19, 35, 43, 5, 24, 41, 5, 6, 37 ]

12

true

Domain

RWD domain

RWD_dom

7

IPR006576

6,576

BRK domain

BRK_domain

Domain

11,651

false

The function of this domain is unknown [ ]. It is often found associated with helicases and transcription factors.

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF07533", "SM00592" ]

[ "BRK", "BRK" ]

[ 10734, 11289 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "3.6.4.-", "PWY-7250", "R-BTA-1266695", "R-BTA-201722", "R-BTA-3214858", "R-BTA-3247509", "R-BTA-8939243", "R-BTA-9764725", "R-BTA-9933937", "R-BTA-9933939", "R-BTA-9933946", "R-BTA-9933947", "R-BTA-9934037", "R-CEL-8939243", "R-CEL-9764725", "R-CEL-9933939", "R-CEL-9934037", "R-DM...

[ "EC:3.6.4.-", "METACYC:PWY-7250", "REACTOME:R-BTA-1266695", "REACTOME:R-BTA-201722", "REACTOME:R-BTA-3214858", "REACTOME:R-BTA-3247509", "REACTOME:R-BTA-8939243", "REACTOME:R-BTA-9764725", "REACTOME:R-BTA-9933937", "REACTOME:R-BTA-9933939", "REACTOME:R-BTA-9933946", "REACTOME:R-BTA-9933947", ...

81

[ "2cka", "2ckc", "2dl6", "2v0e", "2v0f", "6lth", "6ltj", "6sy2", "7vdt", "7vdv", "7y8r" ]

11

[ "PUB00011448" ]

[ "11779830" ]

[ "Systematic identification of novel protein domain families associated with nuclear functions." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 11651 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 45, 13, 44, 19, 27 ]

6

true

Domain

BRK domain

BRK_domain

3

IPR006577

6,577

UAS

Domain

11,812

false

UAS is a domain of unknown function found in FAF1 proteins (FAS-associated factor 1) and in other proteins, many of which are described as having no known function.

[]

0

[ "SMART" ]

[ "SM00594" ]

[ "UAS" ]

[ 11812 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6798695", "R-BTA-8980692", "R-DDI-8951664", "R-DDI-9755511", "R-HSA-6798695", "R-HSA-8951664", "R-HSA-8980692", "R-HSA-9755511", "R-MMU-6798695", "R-MMU-8951664", "R-MMU-8980692", "R-MMU-9755511", "R-RNO-6798695", "R-RNO-8980692", "R-SCE-8951664", "R-SCE-9755511", "R-SPO-67986...

[ "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8980692", "REACTOME:R-DDI-8951664", "REACTOME:R-DDI-9755511", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9755511", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-8951664", "REACTOME:R-MMU-8980692", "REACTOM...

22

[ "2dlx", "2ec4", "2lst" ]

3

[]

0

[]

[ "IPR049483" ]

0

1

0

[ "Bacteria", "Eukaryota" ]

[ 75, 11737 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 24, 2, 6, 7, 10, 6, 2, 18, 19, 2, 2, 28 ]

12

true

Domain

UAS

2

IPR006578

6,578

MADF domain

MADF-dom

Domain

21,061

false

The MADF (myb/SANT-like domain in Adf-1) domain is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain [ ]. M...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF10545", "PS51029" ]

[ "MADF_DNA_bdg", "MADF" ]

[ 20730, 18196 ]

2

[ "PROSITEDOC" ]

[ "PDOC51029" ]

[ "PROSITEDOC:PDOC51029" ]

1

[]

0

[ "PUB00018477", "PUB00018478", "PUB00018479", "PUB00158965" ]

[ "1731341", "9528796", "12459265", "38769058" ]

[ "Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb oncoproteins.", "Adf-1 is a nonmodular transcription factor that contains a TAF-binding Myb-like motif.", "The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist.", "New Drosophila promoter-associated ar...

[ 1992, 1998, 2002, 2024 ]

4

[]

0

null

[ "Bacteria", "Betaentomopoxvirus", "Eukaryota" ]

[ 4, 2, 21055 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster" ]

[ 15, 16, 127 ]

3

true

Domain

MADF domain

MADF-dom

6

IPR006579

6,579

Pre-C2HC domain

Pre_C2HC_dom

Domain

2,536

false

This domain (PRE_C2HC) is present in proteins associated with nuclear functions [ ] and is found exclusively in the arthropods, including a number of Drosophila species, the silk moth and the gypsy moth. These proteins are possibly involved in RNA binding or single strand DNA binding.

[]

0

[ "PFAM", "SMART" ]

[ "PF07530", "SM00596" ]

[ "PRE_C2HC", "PRE_C2HC" ]

[ 2529, 1392 ]

2

[]

0

[]

0

[ "PUB00011448" ]

[ "11779830" ]

[ "Systematic identification of novel protein domain families associated with nuclear functions." ]

[ 2002 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 2536 ]

1

[ "Drosophila melanogaster" ]

[ 16 ]

1

true

Domain

Pre-C2HC domain

Pre_C2HC_dom

2

IPR006580

6,580

Zinc finger, TTF-type

Znf_TTF

Domain

6,796

false

The TTF zinc finger domain is found in transposases and transcription factors. It is present in eukaryotic proteins but has not been identified in any from fungi and nematodes. Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with the...

[]

0

[ "SMART" ]

[ "SM00597" ]

[ "ZnF_TTF" ]

[ 6796 ]

1

[]

0

[]

0

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001 ]

6

[]

0

null

[ "Eukaryota" ]

[ 6796 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 24, 1, 2, 2, 34, 4, 58 ]

7

true

Domain

Zinc finger, TTF-type

Znf_TTF

4

IPR006581

6,581

VPS10

Domain

10,917

false

Yeast Vps10p is a receptor for sorting and transport of the soluble vacuolar hydrolase carboxypeptidase Y to the lysosome-like vacuole [ ]. In mammalian cells, proteins containing this domain are involved in the transport of lipoproteins and sorting of endosomal proteins. They may also act as receptors for some neurope...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "SMART" ]

[ "SM00602" ]

[ "VPS10" ]

[ 10917 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-432722", "R-HSA-977225", "R-MMU-432722", "R-RNO-432722" ]

[ "REACTOME:R-HSA-432722", "REACTOME:R-HSA-977225", "REACTOME:R-MMU-432722", "REACTOME:R-RNO-432722" ]

4

[ "3f6k", "3wsx", "3wsy", "3wsz", "4msl", "4n7e", "4po7", "5mrh", "5mri", "5nmr", "5nmt", "5nni", "5nnj", "5znn", "6eho", "6ffy", "6fg9", "6x3l", "6x48", "6x4h", "7vt0", "8t8r", "8t8s" ]

23

[ "PUB00007963", "PUB00009685", "PUB00009686" ]

[ "11801606", "10600506", "10329739" ]

[ "The yeast Vps10p cytoplasmic tail mediates lysosomal sorting in mammalian cells and interacts with human GGAs.", "Identification and characterization of SorCS, a third member of a novel receptor family.", "Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport." ]

[ 2002, 1999, 1999 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "hydrocarbon metagenome" ]

[ 7, 10909, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 26, 15, 17, 1, 17, 5, 1 ]

7

true

Domain

VPS10

5

IPR006582

6,582

MD domain

MD_domain

Domain

336

false

MD is a domain of unknown function found in a number of Caenorhabditis elegans and Caenorhabditis briggsae hypothetical proteins.

[]

0

[ "SMART" ]

[ "SM00604" ]

[ "MD" ]

[ 336 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chromadorea" ]

[ 336 ]

1

[ "Caenorhabditis elegans" ]

[ 5 ]

1

true

Domain

MD domain

MD_domain

2

IPR006583

6,583

PAN-3 domain

PAN-3_domain

Domain

1,116

false

PAN domains have significant functional versatility fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions [ ]. These domains contain a hair-pin loop like structure, similar to knottins, but the pattern of disulphide bonds differs. The PAN-3 or CW is a domain associate...

[]

0

[ "PFAM", "SMART" ]

[ "PF08277", "SM00605" ]

[ "PAN_3", "CW" ]

[ 1104, 676 ]

2

[]

0

[]

0

[ "PUB00005679" ]

[ "10561497" ]

[ "The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins." ]

[ 1999 ]

1

[]

0

null

[ "Cupriavidus necator", "Eukaryota" ]

[ 1, 1115 ]

2

[ "Caenorhabditis elegans" ]

[ 58 ]

1

true

Domain

PAN-3 domain

PAN-3_domain

3

IPR006584

6,584

Cellulose binding, type IV

Cellulose-bd_IV

Domain

14,691

false

This entry represents a type IV cellulose binding domain. It is a sub-domain of the carbohydrate-binding module, family 6 ( ). Regarding the function, it shows endohydrolysis of 1,4-beta-d-xylosidic linkages in xylans [ ].

[ "GO:0030246" ]

[ "carbohydrate binding" ]

[ "molecular_function" ]

1

[ "SMART" ]

[ "SM00606" ]

[ "CBD_IV" ]

[ 14691 ]

1

[]

0

[ "1gmm", "1nae", "1o8p", "1o8s", "1od3", "1uxx", "1uxz", "1uy0", "1uy1", "1uy2", "1uy3", "1uy4", "1uyx", "1uyy", "1uyz", "1uz0", "1w9s", "1w9t", "1w9w", "2cdo", "2cdp", "2v4v", "2y8k", "3c7e", "3c7f", "3c7g", "3c7h", "3c7o", "5fui", "5g56", "5la0", "5la1"...

36

[ "PUB00034658" ]

[ "1938968" ]

[ "Two beta-glycanase genes are clustered in Bacillus polymyxa: molecular cloning, expression, and sequence analysis of genes encoding a xylanase and an endo-beta-(1,3)-(1,4)-glucanase." ]

[ 1991 ]

1

[ "IPR005084" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 14078, 451, 125, 37 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

Cellulose binding, type IV

Cellulose-bd_IV

3

IPR006585

6,585

Fucolectin tachylectin-4 pentraxin-1

FTP1

Domain

8,235

false

Lectins, a group of proteins that bind to cell surface carbohydrates and play important roles in innate immunity, are widely used experimentally to distinguish cell types and to induce cell proliferation. Eel serum lectins have been useful as anti-H hemagglutinins and also in lectin histochemistry as fucose-binding lec...

[]

0

[ "SMART" ]

[ "SM00607" ]

[ "FTP" ]

[ 8235 ]

1

[]

0

[ "1k12", "2j1r", "2j1s", "2j1t", "2j1u", "2j1v", "2j22", "3cqo", "3le0", "3leg", "3lei", "3lek", "4gwi", "4gwj" ]

14

[ "PUB00007964" ]

[ "10924498" ]

[ "Multiplicity, structures, and endocrine and exocrine natures of eel fucose-binding lectins." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 739, 7488, 8 ]

3

[ "Danio rerio", "Drosophila melanogaster" ]

[ 18, 7 ]

2

true

Domain

Fucolectin tachylectin-4 pentraxin-1

FTP1

9

IPR006586

6,586

ADAM, cysteine-rich domain

ADAM_Cys-rich

Domain

31,567

false

A Disintegrin and Metalloproteinase (ADAM) is a family of proteolytic enzymes that regulate shedding of membrane-bound proteins, growth factors, cytokines, ligands and receptors [ ]. This group of proteins are fundamental to many control processes in development and homeostasis, and they are linked to pathological stat...

[]

0

[ "PFAM", "SMART" ]

[ "PF08516", "SM00608" ]

[ "ADAM_CR", "ACR" ]

[ 23277, 31530 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "3.4.24.-", "PWY-8119", "R-CEL-1474228", "R-CEL-6798695", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1650814", "R-HSA-177929", "R-HSA-2534343", "R-HSA-5083635", "R-HSA-5173214", "R-HSA-5682910", "R-HSA-6798695", "R-HSA-75892", "R-HSA-8941237", "R-HSA-9762292", "R-HSA-9845619", "R-HSA...

[ "EC:3.4.24.-", "METACYC:PWY-8119", "REACTOME:R-CEL-1474228", "REACTOME:R-CEL-6798695", "REACTOME:R-HSA-1442490", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-1650814", "REACTOME:R-HSA-177929", "REACTOME:R-HSA-2534343", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-HSA-5682910", ...

29

[ "2dw0", "2dw1", "2dw2", "2e3x", "2ero", "2erp", "2erq", "2jih", "2rjp", "2rjq", "2v4b", "3b2z", "3dsl", "3g5c", "3ghm", "3ghn", "3hdb", "3k7l", "3k7n", "3q2g", "3q2h", "3vn4", "5y2z", "5y31", "6qig", "8hpy", "8hq1", "8hq2", "8y6b", "9clp", "9kzc", "9kzt"...

32

[ "PUB00007965", "PUB00010250", "PUB00020872", "PUB00098761", "PUB00098763" ]

[ "11193153", "12514095", "12460986", "30905657", "18762209" ]

[ "Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure.", "The ADAMs family of metalloproteases: multidomain proteins with multiple functions.", "The cysteine-rich domain regulates ADAM protease function in vivo.", "A Disintegrin and Metalloproteinase (ADAM) and A...

[ 2000, 2003, 2002, 2019, 2008 ]

5

[]

0

null

[ "Eukaryota", "Tsuneonella suprasediminis" ]

[ 31566, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 90, 17, 96, 118, 128 ]

6

true

Domain

ADAM, cysteine-rich domain

ADAM_Cys-rich

7

IPR006588

6,588

Peptide N glycanase, PAW domain

Peptide_N_glycanase_PAW_dom

Domain

1,941

false

The PAW domain (present in PNGases and other worm proteins) is found as a single copy at the C terminus of metazoan peptide:N-glycanase (PNGase) and in multiple copies in hypothetical Caenorhabditis elegans proteins peptide:N-glycanases (PNGases) [ ]. The C-terminal PAW domain of PNGase binds to the mannose moieties of...

[ "GO:0006516", "GO:0005737" ]

[ "glycoprotein catabolic process", "cytoplasm" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PROFILE", "SMART" ]

[ "PF04721", "PS51398", "SM00613" ]

[ "PAW", "PAW", "PAW" ]

[ 1831, 1683, 1216 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.1.52", "R-CEL-532668", "R-DME-532668", "R-DRE-532668", "R-HSA-532668", "R-MMU-532668", "R-RNO-532668" ]

[ "EC:3.5.1.52", "REACTOME:R-CEL-532668", "REACTOME:R-DME-532668", "REACTOME:R-DRE-532668", "REACTOME:R-HSA-532668", "REACTOME:R-MMU-532668", "REACTOME:R-RNO-532668" ]

7

[ "2g9f", "2g9g", "2i74" ]

3

[ "PUB00011448", "PUB00041628" ]

[ "11779830", "17088551" ]

[ "Systematic identification of novel protein domain families associated with nuclear functions.", "Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module." ]

[ 2002, 2006 ]

2

[]

0

null

[ "Bacteria", "Candidatus Argoarchaeum ethanivorans", "Eukaryota", "marine sediment metagenome" ]

[ 8, 1, 1931, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 20, 2, 1, 5, 3, 5 ]

6

true

Domain

Peptide N glycanase, PAW domain

Peptide_N_glycanase_PAW_dom

7

IPR006590

6,590

RNA polymerase Rpb4/RPC9, core

RNA_pol_Rpb4/RPC9_core

Domain

8,270

false

DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-directed RNA polymerases transcribing different sets of genes. Most RNA polymerase...

[]

0

[ "SMART" ]

[ "SM00657" ]

[ "RPOL4c" ]

[ 8270 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-112382", "R-BTA-113418", "R-BTA-5578749", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-6803529", "R-BTA-6807505", "R-BTA-72086", "R-BTA-72163", "R-BTA-72165", "R-BTA-72203", "R-BTA-73776", "R-BTA-73779", "R-BTA-75953", "R-BTA-759...

[ "REACTOME:R-BTA-112382", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5578749", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-6807505", "REACTOME:R-BTA-72086", "REACTOME:R-B...

170

[ "1nt9", "1pqv", "1wcm", "1y14", "1y1v", "1y1w", "1y1y", "1y77", "2b63", "2b8k", "2c35", "2ja5", "2ja6", "2ja7", "2ja8", "2r7z", "2r92", "2r93", "2vum", "3ayh", "3fki", "3h0g", "3h3v", "3hou", "3hov", "3how", "3hox", "3hoy", "3hoz", "3i4m", "3i4n", "3j0k"...

338

[ "PUB00000061", "PUB00007967", "PUB00033173" ]

[ "3052291", "11087726", "10499798" ]

[ "Structure and function of bacterial sigma factors.", "Dissociable Rpb4-Rpb7 subassembly of rna polymerase II binds to single-strand nucleic acid and mediates a post-recruitment step in transcription initiation.", "Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution." ]

[ 1988, 2001, 1999 ]

3

[]

0

null

[ "Eukaryota", "Thermoproteati", "metagenomes" ]

[ 8257, 11, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 22, 2, 3, 5, 9, 4, 1, 9, 8, 1, 2, 19 ]

12

true

Domain

RNA polymerase Rpb4/RPC9, core

RNA_pol_Rpb4/RPC9_core

6

IPR006591

6,591

RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4

RNAP_P/RPABC4

Family

4,280

false

This family includes the DNA-directed RNA polymerases I, II, and III subunit RPABC4 (also known as RPC10 and ABC10-alpha) [ ] and archaeal polymerase subunit P [ ]. DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence comple...

[ "GO:0003677", "GO:0003899", "GO:0006351" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "SMART" ]

[ "PF03604", "SM00659" ]

[ "Zn_ribbon_RPAB4", "RPOLCX" ]

[ 3989, 4250 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.6", "R-BTA-112382", "R-BTA-113418", "R-BTA-5250924", "R-BTA-5578749", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-6803529", "R-BTA-6807505", "R-BTA-72086", "R-BTA-72163", "R-BTA-72165", "R-BTA-72203", "R-BTA-73762", "R-BTA-73772...

[ "EC:2.7.7.6", "REACTOME:R-BTA-112382", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5250924", "REACTOME:R-BTA-5578749", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-6807505...

168

[ "1i3q", "1i50", "1i6h", "1k83", "1nik", "1nt9", "1pqv", "1r5u", "1r9s", "1r9t", "1sfo", "1twa", "1twc", "1twf", "1twg", "1twh", "1wcm", "1y1v", "1y1w", "1y1y", "1y77", "2b63", "2b8k", "2e2h", "2e2i", "2e2j", "2ja5", "2ja6", "2ja7", "2ja8", "2nvq", "2nvt"...

531

[ "PUB00000061", "PUB00033173", "PUB00059148", "PUB00059151" ]

[ "3052291", "10499798", "19419240", "10559229" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution.", "Evolution of Complex RNA Polymerases: The Complete Archaeal RNA Polymerase Structure.", "Interaction between yeast RNA polymerase III and transcription factor TFIIIC via AB...

[ 1988, 1999, 2009, 1999 ]

4

[]

[ "IPR023464", "IPR039747" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctdvJ3", "ecological metagenomes" ]

[ 759, 35, 3465, 1, 20 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 1, 2, 4, 1, 6, 3, 1, 1, 9 ]

12

true

Family

RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4

RNAP_P/RPABC4

4

IPR006592

6,592

RNA polymerase, N-terminal

RNA_pol_N

Domain

71,912

false

The task of transcribing nuclear genes is shared between three RNA polymerases in eukaryotes: RNA polymerase (pol) I synthesizes the large rRNA, pol II synthesizes mRNA and pol III synthesizes tRNA and 5S rRNA [ ]. Pol I transcription is localised to discrete sites called nucleoli; these can be likened to ribosome fact...

[ "GO:0003677", "GO:0003899", "GO:0006351" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "SMART" ]

[ "SM00663" ]

[ "RPOLA_N" ]

[ 71912 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.6", "R-BTA-112382", "R-BTA-113418", "R-BTA-5578749", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-6803529", "R-BTA-6807505", "R-BTA-72086", "R-BTA-72163", "R-BTA-72165", "R-BTA-72203", "R-BTA-73776", "R-BTA-73779", "R-BTA-75953",...

[ "EC:2.7.7.6", "REACTOME:R-BTA-112382", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5578749", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-6807505", "REACTOME:R-BTA-72086",...

209

[ "1hqm", "1i3q", "1i50", "1i6h", "1i6v", "1iw7", "1k83", "1l9u", "1l9z", "1nik", "1nt9", "1pqv", "1r5u", "1r9s", "1r9t", "1sfo", "1smy", "1twa", "1twc", "1twf", "1twg", "1twh", "1wcm", "1y1v", "1y1w", "1y1y", "1y77", "1ynj", "1ynn", "1zyr", "2a68", "2a69"...

1,221

[ "PUB00028105", "PUB00028106" ]

[ "10684922", "8689574" ]

[ "Survey and summary: transcription by RNA polymerases I and III.", "The nucleolus." ]

[ 2000, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 969, 26947, 42733, 472, 791 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 32, 3, 5, 8, 1, 15, 14, 3, 27, 8, 3, 3, 77 ]

13

true

Domain

RNA polymerase, N-terminal

RNA_pol_N

2

IPR006593

6,593

Cytochrome b561/ferric reductase, transmembrane domain

Cyt_b561/ferric_Rdtase_TM

Domain

29,098

false

Cytochromes b561 constitute a class of intrinsic membrane proteins containing two haem molecules that are involved in ascorbate (vitamin C) regeneration. They have been suggested to function as electron transporters, shuttling electrons across membranes from ascorbate to an acceptor molecule. The one-electron oxidation...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03188", "PS50939", "SM00665" ]

[ "Cytochrom_B561", "CYTOCHROME_B561", "B561" ]

[ 22083, 25724, 27646 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC50939", "R-CEL-917937", "R-DRE-917937", "R-HSA-917937", "R-MMU-917937", "R-RNO-917937", "R-XTR-917937" ]

[ "PROSITEDOC:PDOC50939", "REACTOME:R-CEL-917937", "REACTOME:R-DRE-917937", "REACTOME:R-HSA-917937", "REACTOME:R-MMU-917937", "REACTOME:R-RNO-917937", "REACTOME:R-XTR-917937" ]

7

[ "4o6y", "4o79", "4o7g", "5zle", "5zlg" ]

5

[ "PUB00018313", "PUB00018403", "PUB00018404" ]

[ "11532994", "12801412", "12768339" ]

[ "Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?", "A phylogenetic study of cytochrome b561 proteins.", "Structure prediction for the di-heme cytochrome b561 protein family." ]

[ 2001, 2003, 2003 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Marseilleviridae", "metagenomes" ]

[ 13, 227, 28844, 3, 11 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 72, 12, 20, 37, 29, 20, 4, 58, 21, 87 ]

10

true

Domain

Cytochrome b561/ferric reductase, transmembrane domain

Cyt_b561/ferric_Rdtase_TM

2

IPR006594

6,594

LIS1 homology motif

LisH

Conserved_site

79,292

false

The 33-residue LIS1 homology (LisH) motif is found in eukaryotic intracellular proteins involved in microtubule dynamics, cell migration, nucleokinesis and chromosome segregation. The LisH motif is likely to possess a conserved protein-binding function and it has been proposed that LisH motifs contribute to the regulat...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PFAM", "PROFILE", "SMART" ]

[ "PF08513", "PF16045", "PS50896", "SM00667" ]

[ "LisH", "LisH_2", "LISH", "LisH" ]

[ 19006, 2520, 78918, 47453 ]

4

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC50896", "R-BTA-72163", "R-BTA-9861718", "R-CEL-674695", "R-CEL-6807505", "R-CEL-6811436", "R-CEL-73776", "R-CEL-73779", "R-CEL-75953", "R-CEL-76042", "R-CEL-983168", "R-CEL-9907900", "R-DDI-193648", "R-DDI-9013148", "R-DDI-9013149", "R-DDI-9861718", "R-DME-3214815", "R-DME-350...

[ "PROSITEDOC:PDOC50896", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-9861718", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-6807505", "REACTOME:R-CEL-6811436", "REACTOME:R-CEL-73776", "REACTOME:R-CEL-73779", "REACTOME:R-CEL-75953", "REACTOME:R-CEL-76042", "REACTOME:R-CEL-983168", "REACTOME:R-CEL-990790...

179

[ "1uuj", "1vyh", "2d68", "2xtc", "2xtd", "2xte", "4oyu", "4zhe", "5c6q", "5c6v", "5c7e", "5c7f", "5en6", "5en7", "5en8", "5j9k", "5ja5", "5jgc", "5jhp", "5nqs", "5nqv", "5o9z", "6ahd", "6hqa", "6iwv", "6mzc", "6mzd", "6mzl", "6mzm", "6q8f", "6q8i", "6q8j"...

98

[ "PUB00007968", "PUB00011841", "PUB00011842", "PUB00020892" ]

[ "11734546", "12384287", "12559565", "16051270" ]

[ "A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration.", "Characterization of a Drosophila melanogaster orthologue of muskelin.", "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM.", "The struct...

[ 2001, 2002, 2003, 2005 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 25, 765, 78495, 3, 4 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 136, 18, 133, 34, 155, 87, 11, 60, 122, 6, 11, 238 ]

12

true

Conserved_site

LIS1 homology motif

LisH

7

IPR006595

6,595

CTLH, C-terminal LisH motif

CTLH_C

Domain

37,292

false

The 33-residue LIS1 homology (LisH) motif ( ) is found in eukaryotic intracellular proteins involved in microtubule dynamics, cell migration, nucleokinesis and chromosome segregation. The LisH motif is likely to possess a conserved protein-binding function and it has been proposed that LisH motifs contribute to the reg...

[]

0

[ "PROFILE", "SMART" ]

[ "PS50897", "SM00668" ]

[ "CTLH", "CTLH" ]

[ 37234, 32293 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC50896", "R-BTA-72163", "R-BTA-9861718", "R-DDI-9861718", "R-DME-9861718", "R-DRE-5673001", "R-DRE-8851805", "R-DRE-9861718", "R-GGA-9861718", "R-HSA-373760", "R-HSA-5673001", "R-HSA-72163", "R-HSA-8851805", "R-HSA-9861718", "R-MMU-373760", "R-MMU-5673001", "R-MMU-72163", "R-MM...

[ "PROSITEDOC:PDOC50896", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-9861718", "REACTOME:R-DDI-9861718", "REACTOME:R-DME-9861718", "REACTOME:R-DRE-5673001", "REACTOME:R-DRE-8851805", "REACTOME:R-DRE-9861718", "REACTOME:R-GGA-9861718", "REACTOME:R-HSA-373760", "REACTOME:R-HSA-5673001", "REACTOME:R-H...

27

[ "4zhe", "5c6q", "5c6v", "5c7e", "5c7f", "5en6", "5en7", "5en8", "5j9k", "5ja5", "5jgc", "5jhp", "5nqs", "5nqv", "5o9z", "6ahd", "6q8f", "6q8i", "6q8j", "6swy", "7ns3", "7ns4", "7nsb", "7nsc", "7wej", "7wek", "7wug", "8h6k", "8h6l", "8pjn", "8pmq", "8qbn"...

36

[ "PUB00007968", "PUB00011841", "PUB00011842" ]

[ "11734546", "12384287", "12559565" ]

[ "A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration.", "Characterization of a Drosophila melanogaster orthologue of muskelin.", "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM." ]

[ 2001, 2002, 2003 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 72, 37217, 3 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 110, 9, 22, 19, 34, 20, 5, 26, 35, 4, 4, 140 ]

12

true

Domain

CTLH, C-terminal LisH motif

CTLH_C

3

IPR006597

6,597

Sel1-like repeat

Sel1-like

Repeat

93,037

false

Sel1-like repeats are tetratricopeptide repeat sequences originally identified in a Caenorhabditis elegans receptor molecule which is a key negative regulator of the Notch pathway [ ]. Mammalian homologues have since been identified although these mainly pancreatic proteins have yet to have a function assigned.

[]

0

[ "PFAM", "SMART" ]

[ "PF08238", "SM00671" ]

[ "Sel1", "SEL1" ]

[ 79816, 91465 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1912420", "R-HSA-382556", "R-HSA-5358346", "R-HSA-5362768", "R-HSA-5610787", "R-HSA-5620924", "R-HSA-5678895", "R-HSA-901032", "R-HSA-9613829", "R-HSA-9615710", "R-HSA-9646399", "R-HSA-9840373", "R-MMU-382556", "R-MMU-5358346", "R-MMU-9840373", "R-RNO-382556", "R-RNO-5358346",...

[ "REACTOME:R-HSA-1912420", "REACTOME:R-HSA-382556", "REACTOME:R-HSA-5358346", "REACTOME:R-HSA-5362768", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-HSA-5678895", "REACTOME:R-HSA-901032", "REACTOME:R-HSA-9613829", "REACTOME:R-HSA-9615710", "REACTOME:R-HSA-9646399", "REACTOME:...

19

[ "1klx", "1na0", "1na3", "1ouv", "2avp", "2fo7", "2hyz", "2wqh", "3e4b", "3kd7", "3rjv", "4bwr", "5b26", "5hrz", "5jjo", "5jkp", "5v7v", "6deh", "6lch", "6ok0", "6ok3", "6onw", "6orc", "6ork", "6ur7", "6v8e", "6vfh", "6vfi", "6vfj", "6vfk", "6vjy", "6vjz"...

77

[ "PUB00007970" ]

[ "8722778" ]

[ "The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein." ]

[ 1996 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 117, 47217, 44441, 247, 1015 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 37, 3, 19, 3, 3, 23, 17, 6, 12, 27, 5, 7, 58 ]

13

true

Repeat

Sel1-like repeat

Sel1-like

4

IPR006599

6,599

CARP motif

CARP_motif

Domain

13,310

false

This entry represents the CARP motif, which occurs as a tandem repeat in the C-terminal of many cyclase-associated proteins (CAPs), as well as in tubulin binding cofactor C and the X-linked retinitis pigmentosa 2 protein (RP2).

[]

0

[ "SMART" ]

[ "SM00673" ]

[ "CARP" ]

[ 13310 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6798695", "R-DRE-5624138", "R-GGA-5624138", "R-HSA-114608", "R-HSA-389977", "R-HSA-428890", "R-HSA-5624138", "R-HSA-6798695", "R-MMU-5624138", "R-MMU-6798695", "R-RNO-6798695", "R-SCE-6798695", "R-SPO-6798695" ]

[ "REACTOME:R-DDI-6798695", "REACTOME:R-DRE-5624138", "REACTOME:R-GGA-5624138", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-389977", "REACTOME:R-HSA-428890", "REACTOME:R-HSA-5624138", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-5624138", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-6798695", "REACTOME:R...

13

[ "1k4z", "1k8f", "1kq5", "2b0r", "2bx6", "2yuh", "3bh6", "3bh7", "5aj8", "6fm2", "9m1m", "9m1n" ]

12

[]

0

[]

0

null

[ "Eukaryota", "Verminephrobacter aporrectodeae subsp. tuberculatae" ]

[ 13309, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 23, 6, 9, 4, 18, 13, 3, 14, 22, 1, 2, 43 ]

12

true

Domain

CARP motif

CARP_motif

1

IPR006600

6,600

HTH CenpB-type DNA-binding domain

HTH_CenpB_DNA-bd_dom

Domain

32,865

false

The CENPB-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 70-75 amino acids, present in eukaryotic centromere proteins and transposases. The domain is named after the mammalian major centromere autoantigen B or centromere protein B (CENP-B), which is a fundamental centromere component of chromo...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03221", "PS51253", "SM00674" ]

[ "HTH_Tnp_Tc5", "HTH_CENPB", "CENPB" ]

[ 28699, 30463, 20041 ]

3

[ "PROSITEDOC" ]

[ "PDOC51253" ]

[ "PROSITEDOC:PDOC51253" ]

1

[ "1hlv", "1iuf" ]

2

[ "PUB00025705", "PUB00035346", "PUB00053387", "PUB00053388", "PUB00053389", "PUB00053390", "PUB00053391", "PUB00059157", "PUB00059158", "PUB00059159" ]

[ "11726497", "16183641", "9097724", "9862965", "15487591", "8264540", "19013460", "17112379", "9237993", "11238404" ]

[ "Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA.", "Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences.", "Centromeres, CENP-B and Tigger too.", "Pogo transposase contains a putativ...

[ 2001, 2005, 1997, 1999, 2004, 1993, 2008, 2006, 1997, 2001 ]

10

[]

0

null

[ "Bacteria", "Bracoviriform inaniti", "Eukaryota" ]

[ 11, 1, 32853 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizo...

[ 1, 9, 5, 9, 33, 22, 4, 25, 1, 3 ]

10

true

Domain

HTH CenpB-type DNA-binding domain

HTH_CenpB_DNA-bd_dom

4

IPR006601

6,601

Uncharacterised protein family DM11, Drosophila melanogaster

Uncharacterised_DM11_DROME

Family

385

false

This family consists of a group of Drosophila melanogaster proteins of unknown function. A number of these proteins are expressed in nonneuronal auxiliary cells within two nested subsets of chemosensory sensilla on the front legs of male D. melanogaster, suggesting they may be involved in pheromone response [ ]. These ...

[]

0

[ "SMART" ]

[ "SM00675" ]

[ "DM11" ]

[ 385 ]

1

[]

0

[]

0

[ "PUB00009688" ]

[ "11904775" ]

[ "Novel genes expressed in subsets of chemosensory sensilla on the front legs of male Drosophila melanogaster." ]

[ 2002 ]

1

[]

0

null

[ "Diptera" ]

[ 385 ]

1

[ "Drosophila melanogaster" ]

[ 22 ]

1

true

Family

Uncharacterised protein family DM11, Drosophila melanogaster

Uncharacterised_DM11_DROME

7

IPR006602

6,602

DM10 domain

DM10_dom

Domain

7,309

false

This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. The DM10 domain has been identified in only two types of proteins: nucleoside diphosphate kinases (which contain a single copy of the DM10 domain) and in an uncharacterised class of proteins (which contain mul...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF06565", "PS51336", "SM00676" ]

[ "DM10_dom", "DM10", "DM10" ]

[ 4923, 7260, 7022 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-380270", "R-BTA-380320", "R-HSA-380270", "R-HSA-380320", "R-MMU-380270", "R-MMU-380320", "R-RNO-380270", "R-RNO-380320" ]

[ "REACTOME:R-BTA-380270", "REACTOME:R-BTA-380320", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380320", "REACTOME:R-MMU-380270", "REACTOME:R-MMU-380320", "REACTOME:R-RNO-380270", "REACTOME:R-RNO-380320" ]

8

[ "2z13", "2z14", "6u42", "7rro", "7ung", "8g2z", "8g3d", "8glv", "8i7o", "8i7r", "8iyj", "8j07", "8otz", "8sf7", "8snb", "8to0", "9cpb", "9cpc", "9d5n", "9e2g", "9e5c", "9e78", "9fqr" ]

23

[ "PUB00043716", "PUB00085676", "PUB00087484", "PUB00097750" ]

[ "16572395", "19852809", "21289087", "30349665" ]

[ "Axonemal protofilament ribbons, DM10 domains, and the link to juvenile myoclonic epilepsy.", "Nme protein family evolutionary history, a vertebrate perspective.", "Functional characterization of putative cilia genes by high-content analysis.", "EF-hand domain containing 2 (Efhc2) is crucial for distal segmen...

[ 2006, 2009, 2011, 2018 ]

4

[]

[ "IPR057579" ]

0

1

0

[ "Bacteria", "Candidatus Methanomarinus sp.", "Eukaryota" ]

[ 28, 1, 7280 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 6, 27, 8, 11 ]

6

true

Domain

DM10 domain

DM10_dom

9

IPR006603

6,603

PQ-loop repeat

PQ-loop_rpt

Repeat

30,614

false

Some membrane bound proteins possess a pair of repeats each spanning two transmembrane helices connected by a loop [ ]. The PQ motif found on loop 2 is critical for the localisation of cystinosin to lysosomes [ ]. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought to possess a mor...

[]

0

[ "PFAM", "SMART" ]

[ "PF04193", "SM00679" ]

[ "PQ-loop", "CTNS" ]

[ 30564, 24120 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-425393", "R-BTA-5223345", "R-CEL-425393", "R-CEL-446193", "R-CEL-5223345", "R-DDI-425393", "R-DDI-5223345", "R-DME-425393", "R-DME-446193", "R-DME-5223345", "R-GGA-5223345", "R-HSA-425393", "R-HSA-446193", "R-HSA-4687000", "R-HSA-5223345", "R-MMU-425393", "R-MMU-446193", "R-...

[ "REACTOME:R-BTA-425393", "REACTOME:R-BTA-5223345", "REACTOME:R-CEL-425393", "REACTOME:R-CEL-446193", "REACTOME:R-CEL-5223345", "REACTOME:R-DDI-425393", "REACTOME:R-DDI-5223345", "REACTOME:R-DME-425393", "REACTOME:R-DME-446193", "REACTOME:R-DME-5223345", "REACTOME:R-GGA-5223345", "REACTOME:R-HS...

22

[ "4qnc", "4rng", "4x5m", "4x5n", "5uhs", "7zk1", "7zkw", "7zkz", "8dke", "8dki", "8dkm", "8dkw", "8dkx", "8dyp", "9kax", "9kba" ]

16

[ "PUB00007973", "PUB00010109" ]

[ "11731489", "11150305" ]

[ "Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution.", "The targeting of cystinosin to the lysosomal membrane requires a tyrosine-based signal and a novel sorting motif." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 90, 3002, 27363, 25, 134 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 47, 7, 19, 9, 47, 20, 7, 9, 21, 6, 3, 29 ]

12

true

Repeat

PQ-loop repeat

PQ-loop_rpt

9

IPR006605

6,605

G2 nidogen/fibulin G2F

G2_nidogen/fibulin_G2F

Domain

5,901

false

Basement membranes are sheet-like extracellular matrices found at the basal surfaces of epithelia and condensed mesenchyma. By preventing cell mixing and providing a cell-adhesive substrate, they play crucial roles in tissue development and function. Basement membranes are composed of an evolutionarily ancient set of l...

[]

0

[ "PFAM", "PROFILE", "SMART", "CDD" ]

[ "PF07474", "PS50993", "SM00682", "cd00255" ]

[ "G2F", "NIDOGEN_G2", "G2F", "nidG2" ]

[ 5630, 5871, 5333, 4031 ]

4

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC50993", "R-HSA-1474228", "R-HSA-3000157", "R-MMU-1474228", "R-MMU-3000157", "R-RNO-3000157" ]

[ "PROSITEDOC:PDOC50993", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-3000157", "REACTOME:R-MMU-1474228", "REACTOME:R-MMU-3000157", "REACTOME:R-RNO-3000157" ]

6

[ "1gl4", "1h4u" ]

2

[ "PUB00007972", "PUB00015405", "PUB00081686", "PUB00081687" ]

[ "11427896", "9633511", "8939648", "11222143" ]

[ "Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1.", "Entactin-2: a new member of basement membrane protein with high homology to entactin/nidogen.", "Macromolecular organization of basement membranes.", "Hemicentin, a conserved extracellular member of the immunoglobulin s...

[ 2001, 1998, 1996, 2001 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 3, 116, 5771, 11 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 16, 1, 12, 10, 11 ]

6

true

Domain

G2 nidogen/fibulin G2F

G2_nidogen/fibulin_G2F

8

IPR006606

6,606

BBSome complex member BBS5

BBL5

Family

2,156

false

BBSome complex member BBS5 is part of the BBSome complex that may function as a coat complex required for sorting of specific membrane proteins to the primary cilia [ , ]. Mutations in the BBS5 gene cause Bardet-Biedl syndrome 5, which is a syndrome characterised by usually severe pigmentary retinopathy, early-onset ob...

[ "GO:0034464" ]

[ "BBSome" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR21351" ]

[ "" ]

[ 2156 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5620922", "R-HSA-5620922", "R-MMU-5620922" ]

[ "REACTOME:R-CEL-5620922", "REACTOME:R-HSA-5620922", "REACTOME:R-MMU-5620922" ]

3

[ "6vbu", "6vbv", "6vnw", "6voa", "6xtb" ]

5

[ "PUB00060532", "PUB00073459", "PUB00073460", "PUB00153355" ]

[ "17574030", "15137946", "21344540", "31951201" ]

[ "A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.", "Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.", "BBS genotype-phenotype assessment of a multiethnic patient cohort calls for a revision of t...

[ 2007, 2004, 2011, 2020 ]

4

[ "IPR030804" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2156 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 5, 6, 4, 5 ]

6

true

Family

BBSome complex member BBS5

BBL5

7

IPR006607

6,607

LARP1-like, DM15 repeat

DM15

Repeat

5,651

false

This repeat is found in a highly conserved C-terminal region of La-related protein 1 (LARP1). LARP1 is implicated in the stability, localisation, and translational efficiency of mRNAs required for cell development, migration, division, and general translation [ , ]. Upregulation of this protein occurs in several cancer...

[ "GO:0000339", "GO:0048255" ]

[ "RNA cap binding", "mRNA stabilization" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF21071", "SM00684" ]

[ "LARP1_HEAT", "DM15" ]

[ 5651, 5205 ]

2

[ "REACTOME" ]

[ "R-HSA-9705671" ]

[ "REACTOME:R-HSA-9705671" ]

1

[ "4zc4", "5c0v", "5v4r", "5v7c", "5v87", "6pw3", "8dhu", "8dio", "8xp2", "8xp3", "9ed0" ]

11

[ "PUB00103777", "PUB00103778", "PUB00103779", "PUB00103780", "PUB00103781" ]

[ "26206669", "28379136", "23711370", "20430826", "25531318" ]

[ "The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence.", "La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.", "LARP1 specifically recognizes the 3' terminus of poly(A) mRNA.", "The RNA binding protein Larp1 regulates cell ...

[ 2015, 2017, 2013, 2010, 2015 ]

5

[]

0

null

[ "Eukaryota" ]

[ 5651 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 11, 5, 7, 5, 1, 3, 5, 10 ]

10

true

Repeat

LARP1-like, DM15 repeat

DM15

9

IPR006608

6,608

Coiled-coil and C2 domain-containing protein 1, DM14 domain

CC2D1A/B_DM14

Domain

3,222

false

This is a short helical domain found in multiple copies in most members of this entry. In CC2D1A/B proteins is present four times. Its function is not yet known [ ]. This entry includes coiled-coil and C2 domain-containing protein 1A/B (CC2D1A/B, also known as Freud-1/2). CC2D1A is involved in many pathways, including ...

[]

0

[ "PFAM", "SMART" ]

[ "PF21528", "SM00685" ]

[ "CC2D1A-B_DM14", "DM14" ]

[ 3015, 3204 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-9668328", "R-DME-9668328", "R-HSA-9668328", "R-MMU-9668328", "R-RNO-9668328" ]

[ "REACTOME:R-CEL-9668328", "REACTOME:R-DME-9668328", "REACTOME:R-HSA-9668328", "REACTOME:R-MMU-9668328", "REACTOME:R-RNO-9668328" ]

5

[ "5vny", "5vo5", "7zrv", "7zsd", "7zss" ]

5

[ "PUB00087601", "PUB00087602", "PUB00087603", "PUB00087604", "PUB00090017", "PUB00090019", "PUB00101538" ]

[ "12917378", "17535813", "16033914", "17394259", "27769858", "19423080", "20529849" ]

[ "Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene.", "Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene.", "The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation.", ...

[ 2003, 2007, 2006, 2007, 2016, 2009, 2010 ]

7

[]

0

null

[ "Eukaryota" ]

[ 3222 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 2, 9, 5, 6 ]

6

true

Domain

Coiled-coil and C2 domain-containing protein 1, DM14 domain

CC2D1A/B_DM14

9