LiteFold/InterPro · Datasets at Hugging Face

IPR012340

12,340

Nucleic acid-binding, OB-fold

NA-bd_OB-fold

Homologous_superfamily

1,404,260

false

A five-stranded β-barrel was first noted as a common structure among four proteins binding single-stranded nucleic acids (staphylococcal nuclease and aspartyl-tRNA synthetase) or oligosaccharides (B subunits of enterotoxin and verotoxin-1), and has been termed the oligonucleotide/oligosaccharide binding motif, or OB fo...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:2.40.50.140", "SSF50249" ]

[ "", "" ]

[ 1347176, 1181103 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-112382", "R-BTA-113418", "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1236978", "R-BTA-156827", "R-BTA-174084", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BTA-174411", "R-BTA-174430", "R-BTA-176187", "R-BTA-1799339", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA...

[ "REACTOME:R-BTA-112382", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-156827", "REACTOME:R-BTA-174084", "REACTOME:R-BTA-174154", "REACTOME:R-BTA-174178", "REACTOME:R-BTA-174184", "REACTOME:R-BTA-174411", "REACTOME:R-BTA-...

1,210

[ "1a0i", "1a1d", "1a62", "1a63", "1a8v", "1ae2", "1ae3", "1ah9", "1asy", "1asz", "1b70", "1b7y", "1b8a", "1bbu", "1bbw", "1bdx", "1bkb", "1c04", "1c0a", "1c7y", "1c9o", "1ckm", "1ckn", "1cko", "1csp", "1csq", "1cuk", "1d7q", "1d8l", "1dgs", "1e1o", "1e1t"...

4,438

[ "PUB00011768", "PUB00016305", "PUB00016307" ]

[ "9862955", "15178340", "12769718" ]

[ "RNA binding strategies of ribosomal proteins.", "BOF: a novel family of bacterial OB-fold proteins.", "OB-fold: growing bigger with functional consistency." ]

[ 1999, 2004, 2003 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 32548, 913436, 433431, 6362, 9, 18474 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 743, 77, 230, 137, 48, 478, 334, 64, 503, 373, 55, 65, 1656 ]

13

true

Homologous_superfamily

Nucleic acid-binding, OB-fold

NA-bd_OB-fold

7

IPR012344

12,344

Matrix protein, lentiviral and alpha-retroviral, N-terminal

Matrix_HIV/RSV_N

Homologous_superfamily

65,609

false

Retroviral matrix proteins (or major core proteins) are components of envelope-associated capsids, which line the inner surface of virus envelopes and are associated with viral membranes [ ]. Matrix proteins are produced as part of Gag precursor polyproteins. During viral maturation, the Gag polyprotein is cleaved into...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.150.90" ]

[ "" ]

[ 65609 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1169408", "R-HSA-162585", "R-HSA-162588", "R-HSA-162592", "R-HSA-162594", "R-HSA-164516", "R-HSA-164525", "R-HSA-164843", "R-HSA-173107", "R-HSA-174490", "R-HSA-174495", "R-HSA-175474", "R-HSA-175567", "R-HSA-177539", "R-HSA-180689", "R-HSA-180910" ]

[ "REACTOME:R-HSA-1169408", "REACTOME:R-HSA-162585", "REACTOME:R-HSA-162588", "REACTOME:R-HSA-162592", "REACTOME:R-HSA-162594", "REACTOME:R-HSA-164516", "REACTOME:R-HSA-164525", "REACTOME:R-HSA-164843", "REACTOME:R-HSA-173107", "REACTOME:R-HSA-174490", "REACTOME:R-HSA-174495", "REACTOME:R-HSA-17...

16

[ "1a6s", "1ecw", "1ed1", "1hek", "1hiw", "1l6n", "1tam", "1uph", "2gol", "2h3f", "2h3i", "2h3q", "2h3v", "2h3z", "2hmx", "2jmg", "2k4e", "2k4h", "2k4i", "2lya", "2lyb", "2mgu", "2n1r", "2nv3", "4ic9", "4ica", "4jmu", "5kz9", "5kza", "5kzb", "5o2u", "6ccj"...

56

[ "PUB00014063", "PUB00016320", "PUB00016321", "PUB00016322", "PUB00016323", "PUB00055853" ]

[ "9657938", "12876457", "12465460", "15564464", "11799182", "18647839" ]

[ "Retroviral matrix proteins: a structural perspective.", "The evolution, distribution and diversity of endogenous retroviruses.", "HIV-1 replication.", "Insertion of a classical nuclear import signal into the matrix domain of the Rous sarcoma virus Gag protein interferes with virus replication.", "Structure...

[ 1998, 2003, 2001, 2004, 2002, 2008 ]

6

[]

0

null

[ "Bacteria", "Opisthokonta", "Retroviridae" ]

[ 9, 449, 65151 ]

3

[]

0

true

Homologous_superfamily

Matrix protein, lentiviral and alpha-retroviral, N-terminal

Matrix_HIV/RSV_N

1

IPR012345

12,345

STAT transcription factor, DNA-binding, N-terminal

STAT_TF_DNA-bd_N

Homologous_superfamily

10,629

false

The STAT protein (Signal Transducers and Activators of Transcription) family contains transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors, hence they act as signal transducers in the cytoplasm and transcription activators in the nucleus ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.630" ]

[ "" ]

[ 10629 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1251985", "R-BTA-1266695", "R-BTA-1433557", "R-BTA-186763", "R-BTA-512988", "R-BTA-8854691", "R-BTA-8983432", "R-BTA-8985947", "R-BTA-9020558", "R-BTA-9020958", "R-CEL-1059683", "R-CEL-1169408", "R-CEL-1251985", "R-CEL-186763", "R-CEL-201556", "R-CEL-3249367", "R-CEL-6783783",...

[ "REACTOME:R-BTA-1251985", "REACTOME:R-BTA-1266695", "REACTOME:R-BTA-1433557", "REACTOME:R-BTA-186763", "REACTOME:R-BTA-512988", "REACTOME:R-BTA-8854691", "REACTOME:R-BTA-8983432", "REACTOME:R-BTA-8985947", "REACTOME:R-BTA-9020558", "REACTOME:R-BTA-9020958", "REACTOME:R-CEL-1059683", "REACTOME:...

216

[ "1bf5", "1bg1", "1y1u", "1yvl", "3cwg", "4e68", "4y5u", "4y5w", "5d39", "6mbw", "6mbz", "6njs", "6nuq", "6qhd", "6tlc", "6ux2", "6wcz", "7nuf", "7tva", "7tvb", "7ubt", "7uc6", "7uc7", "7zn7", "7znn", "8d3f", "8t12", "8t13", "8yyu", "8yyv", "9big" ]

31

[ "PUB00007134", "PUB00011807", "PUB00032712", "PUB00051157" ]

[ "12039028", "9630226", "15780933", "18433722" ]

[ "Signaling through the JAK/STAT pathway, recent advances and future challenges.", "Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.", "Structural bases of unphosphorylated STAT1 association and receptor binding.", "Crystal structure of unphosphorylated STAT3 core fragment." ]

[ 2002, 1998, 2005, 2008 ]

4

[]

0

null

[ "Eukaryota" ]

[ 10629 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 29, 6, 100, 33, 28 ]

6

true

Homologous_superfamily

STAT transcription factor, DNA-binding, N-terminal

STAT_TF_DNA-bd_N

8

IPR012346

12,346

p53/RUNT-type transcription factor, DNA-binding domain superfamily

p53/RUNT-type_TF_DNA-bd_sf

Homologous_superfamily

12,491

false

This DNA-binding domain superfamily is found in the p53 and the RUNT families of transcription factors. The DNA-binding domain acts to clamp or encircle the DNA target in order to stabilise the protein-DNA complex. This domain has an immunoglobulin-like fold consisting of a β-sandwich of 9 strands in two sheets with a ...

[ "GO:0003677", "GO:0003700", "GO:0006355", "GO:0005634" ]

[ "DNA binding", "DNA-binding transcription factor activity", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.720" ]

[ "" ]

[ 12491 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-2559580", "R-BTA-2559586", "R-BTA-349425", "R-BTA-5689880", "R-BTA-5689896", "R-BTA-5693565", "R-BTA-6804754", "R-BTA-6804756", "R-BTA-6804757", "R-BTA-6804758", "R-BTA-6804759", "R-BTA-6804760", "R-BTA-6811555", "R-BTA-69473", "R-BTA-69481", "R-BTA-69541", "R-BTA-69895", "R...

[ "REACTOME:R-BTA-2559580", "REACTOME:R-BTA-2559586", "REACTOME:R-BTA-349425", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-5689896", "REACTOME:R-BTA-5693565", "REACTOME:R-BTA-6804754", "REACTOME:R-BTA-6804756", "REACTOME:R-BTA-6804757", "REACTOME:R-BTA-6804758", "REACTOME:R-BTA-6804759", "REACTOME...

248

[ "1cmo", "1co1", "1e50", "1ean", "1eao", "1eaq", "1gzh", "1h9d", "1hjb", "1hjc", "1hu8", "1io4", "1kzy", "1ljm", "1t4w", "1tsr", "1tup", "1uol", "1ycs", "2ac0", "2ady", "2ahi", "2ata", "2bim", "2bin", "2bio", "2bip", "2biq", "2fej", "2geq", "2h1l", "2ioi"...

243

[ "PUB00016330", "PUB00016331", "PUB00016332", "PUB00016334" ]

[ "15735333", "10545320", "15688066", "15359011" ]

[ "Structures of the DNA-binding site of Runt-domain transcription regulators.", "The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.", "p53: traffic cop at the crossroads of DNA repair and recombination.", "Neuro...

[ 2005, 1999, 2005, 2004 ]

4

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 12490, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 131, 18, 210, 45, 39 ]

6

true

Homologous_superfamily

p53/RUNT-type transcription factor, DNA-binding domain superfamily

p53/RUNT-type_TF_DNA-bd_sf

3

IPR012347

12,347

Ferritin-like

Homologous_superfamily

186,563

false

This entry represents ferritin and structurally related proteins. Ferritin is a major non-haem iron storage protein in animal, plants and microorganisms [ ]. Iron is required by most organisms, but is potentially toxic due to its reactivity, which is counteracted by sequestering it into ferritin. Ferritin consists of a...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.1260.10" ]

[ "" ]

[ 186563 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6798695", "R-BTA-917937", "R-CFA-432722", "R-CFA-6798695", "R-CFA-917937", "R-DDI-2142789", "R-GGA-432722", "R-GGA-6798695", "R-GGA-917937", "R-HSA-1222449", "R-HSA-3000480", "R-HSA-432722", "R-HSA-6798695", "R-HSA-917937", "R-MMU-432722", "R-MMU-6798695", "R-MMU-917937", "R...

[ "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-917937", "REACTOME:R-CFA-432722", "REACTOME:R-CFA-6798695", "REACTOME:R-CFA-917937", "REACTOME:R-DDI-2142789", "REACTOME:R-GGA-432722", "REACTOME:R-GGA-6798695", "REACTOME:R-GGA-917937", "REACTOME:R-HSA-1222449", "REACTOME:R-HSA-3000480", "REACTOME:R-H...

20

[ "1aew", "1b71", "1bcf", "1bfr", "1bg7", "1dat", "1dps", "1dvb", "1eum", "1f30", "1f33", "1fha", "1gwg", "1h96", "1hrs", "1ier", "1ies", "1j30", "1jgc", "1ji4", "1ji5", "1jig", "1jku", "1jkv", "1jre", "1jts", "1jyb", "1krq", "1l8h", "1l8i", "1lb3", "1lkm"...

927

[ "PUB00015567", "PUB00016335", "PUB00016336" ]

[ "10811605", "15222465", "15547260" ]

[ "The Crd1 gene encodes a putative di-iron enzyme required for photosystem I accumulation in copper deficiency and hypoxia in Chlamydomonas reinhardtii.", "Iron and proteins for iron storage and detoxification.", "Rubrerythrin from the hyperthermophilic archaeon Pyrococcus furiosus is a rubredoxin-dependent, iro...

[ 2000, 2004, 2004 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 4147, 165219, 14958, 269, 1970 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 28, 2, 15, 9, 8, 27, 25, 1, 10, 46, 16 ]

11

true

Homologous_superfamily

Ferritin-like

4

IPR012348

12,348

Ribonucleotide reductase-like

RNR-like

Homologous_superfamily

70,277

false

The R2 protein of ribonucleotide reductase catalyses the reduction of all four ribonucleotides to deoxyribonucleotides for use in DNA synthesis. This catalysis involves generating and storing a tyrosyl radical, which is essential for ribonucleotide reduction. The crystal structure consists of a core of four helices in ...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "CATHGENE3D" ]

[ "G3DSA:1.10.620.20" ]

[ "" ]

[ 70277 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-499943", "R-DDI-499943", "R-DME-499943", "R-DRE-499943", "R-HSA-499943", "R-HSA-5628897", "R-HSA-69205", "R-HSA-8953750", "R-MMU-499943", "R-RNO-499943", "R-SCE-499943", "R-SPO-499943" ]

[ "REACTOME:R-CEL-499943", "REACTOME:R-DDI-499943", "REACTOME:R-DME-499943", "REACTOME:R-DRE-499943", "REACTOME:R-HSA-499943", "REACTOME:R-HSA-5628897", "REACTOME:R-HSA-69205", "REACTOME:R-HSA-8953750", "REACTOME:R-MMU-499943", "REACTOME:R-RNO-499943", "REACTOME:R-SCE-499943", "REACTOME:R-SPO-49...

12

[ "1afr", "1av8", "1biq", "1fyz", "1fz0", "1fz1", "1fz2", "1fz3", "1fz4", "1fz5", "1fz6", "1fz7", "1fz8", "1fz9", "1fzh", "1fzi", "1h0n", "1h0o", "1jk0", "1jpr", "1jqc", "1kgn", "1kgo", "1kgp", "1mhy", "1mhz", "1mmo", "1mrr", "1mty", "1mxr", "1oq4", "1oq7"...

369

[ "PUB00016337", "PUB00016338" ]

[ "8876648", "8749363" ]

[ "The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2.", "Di-iron-carboxylate proteins." ]

[ 1996, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1318, 52100, 12921, 2759, 1179 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 42, 1, 7, 1, 2, 8, 10, 1, 23, 8, 2, 1, 65 ]

13

true

Homologous_superfamily

Ribonucleotide reductase-like

RNR-like

2

IPR012349

12,349

FMN-binding split barrel

Split_barrel_FMN-bd

Homologous_superfamily

249,436

false

The FMN-binding domain has a split β-barrel structure with a Greek-key topology that is related in structure to the ferredoxin reductase-like FAD-binding domain. The FMN-binding split barrel domain is found in pyridoxine 5'-phoshate oxidase (PNP oxidase), FMN-binding protein, ferric reductase, and in phenol 2-hydroxyla...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.30.110.10" ]

[ "" ]

[ 249436 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-964975", "R-CEL-964975", "R-DDI-964975", "R-GGA-6798695", "R-HSA-6798695", "R-HSA-964975", "R-MMU-6798695", "R-MMU-964975", "R-RNO-964975", "R-SCE-964975", "R-SPO-964975" ]

[ "REACTOME:R-BTA-964975", "REACTOME:R-CEL-964975", "REACTOME:R-DDI-964975", "REACTOME:R-GGA-6798695", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-964975", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-964975", "REACTOME:R-RNO-964975", "REACTOME:R-SCE-964975", "REACTOME:R-SPO-964975" ]

11

[ "1axj", "1ci0", "1dnl", "1eje", "1flm", "1g76", "1g77", "1g78", "1g79", "1i0r", "1i0s", "1jnw", "1nrg", "1oj7", "1pt5", "1pt7", "1pt8", "1rfe", "1rz0", "1rz1", "1t9m", "1ty9", "1uqw", "1usc", "1usf", "1vl7", "1w3o", "1w3p", "1w3q", "1w3r", "1w9a", "1wgb"...

229

[ "PUB00011837", "PUB00016340", "PUB00016342", "PUB00016343", "PUB00016344" ]

[ "10713530", "12829278", "12824491", "12686112", "9406543" ]

[ "How do the x-ray structure and the NMR structure of FMN-binding protein differ?", "Microbial ferric iron reductases.", "Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase.", "Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase.", "Pathway of chymotrypsin e...

[ 2000, 2003, 2003, 2003, 1997 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 4978, 211686, 29748, 10, 3014 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 38, 1, 3, 9, 5, 12, 8, 9, 25, 9, 5, 4, 57 ]

13

true

Homologous_superfamily

FMN-binding split barrel

Split_barrel_FMN-bd

6

IPR012352

12,352

Interleukin-10, additional helical

IL-10_add_hlx

Homologous_superfamily

56

false

Human interleukin-10 (IL-10) is a pleiotropic cytokine that inhibits cell-mediated immune responses, primarily by blocking the synthesis of pro-inflammatory cytokines and by inhibiting the expression of cell surface markers involved in antigen presentation and costimulation. In addition, IL-10 acts to enhance humoral i...

[ "GO:0005125", "GO:0006955" ]

[ "cytokine activity", "immune response" ]

[ "molecular_function", "biological_process" ]

2

[ "CATHGENE3D" ]

[ "G3DSA:4.10.340.10" ]

[ "" ]

[ 56 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "1lqs" ]

1

[ "PUB00016346" ]

[ "12093920" ]

[ "Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1." ]

[ 2002 ]

1

[]

0

null

[ "Human cytomegalovirus" ]

[ 56 ]

1

[]

0

true

Homologous_superfamily

Interleukin-10, additional helical

IL-10_add_hlx

1

IPR012355

12,355

NAD kinase 2, mitochondrial

NADK2_mit

Family

1,121

false

NAD kinase 2 (NADK2) can utilise ATP or inorganic polyphosphate, and is localised in the mitochondria [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF017565" ]

[ "Kin_ATP-NAD_euk" ]

[ 1121 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1.23", "PWY-5083", "PWY-7268", "PWY-7269", "PWY-8148", "R-HSA-196807", "R-HSA-9837999", "R-MMU-196807", "R-MMU-9837999", "R-RNO-196807", "R-RNO-9837999", "R-XTR-196807" ]

[ "EC:2.7.1.23", "METACYC:PWY-5083", "METACYC:PWY-7268", "METACYC:PWY-7269", "METACYC:PWY-8148", "REACTOME:R-HSA-196807", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-196807", "REACTOME:R-MMU-9837999", "REACTOME:R-RNO-196807", "REACTOME:R-RNO-9837999", "REACTOME:R-XTR-196807" ]

12

[ "7n29", "7r4j", "7r4k", "7r4l", "7r4m" ]

5

[ "PUB00070139" ]

[ "23212377" ]

[ "Identification and characterization of a human mitochondrial NAD kinase." ]

[ 2012 ]

1

[ "IPR002504" ]

[]

1

0

1

[ "Bilateria" ]

[ 1121 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 5, 2, 4, 7 ]

6

true

Family

NAD kinase 2, mitochondrial

NADK2_mit

3

IPR012356

12,356

Methanogenesis marker 5 protein

Methan_mark_5

Family

262

false

The exact function of this protein is unknown, but likely is linked to methanogenesis or a process closely connected to it [ ].

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF09885", "PIRSF018781", "TIGR03271" ]

[ "DUF2112", "UCP018781", "methan_mark_5" ]

[ 262, 240, 244 ]

3

[ "GP" ]

[ "GenProp0722" ]

[ "GP:GenProp0722" ]

1

[]

0

[ "PUB00060475" ]

[ "22070167" ]

[ "ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process." ]

[ 2011 ]

1

[]

0

null

[ "Archaea", "Candidatus Parabacteroides intestinigallinarum", "metagenomes" ]

[ 253, 1, 8 ]

3

[]

0

true

Family

Methanogenesis marker 5 protein

Methan_mark_5

8

IPR012357

12,357

Uncharacterised conserved protein UCP024484

UCP024484

Family

31

false

This is a small family of archaeal proteins. Their genes are located in an operon containing two genes of box C/D RNA protein complexes. These proteins adopt α/β structure consisting of two subdomains. The N-terminal subdomain contains a HTH motif whereas the C-terminal subdomain shows a partial structural similarity t...

[]

0

[ "PIRSF" ]

[ "PIRSF024484" ]

[ "UCP024484" ]

[ 31 ]

1

[]

0

[ "5vfk" ]

1

[ "PUB00098020" ]

[ "29526782" ]

[ "Solution structure of an archaeal DUF61 family protein SSO0941 encoded by a gene in the operon of box C/D RNA protein complexes." ]

[ 2018 ]

1

[]

0

null

[ "Thermoprotei" ]

[ 31 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP024484

UCP024484

7

IPR012358

12,358

Endopolyphosphatase, Ppn1p-related

EndopolyPtase_N1

Family

1,310

false

Endopolyphosphatases are enzymes that hydrolyse long inorganic phosphate chains to shorter chains of (predominantly) 60 or 3 phosphate units. The Saccharomyces cerevisiae (Baker's yeast) member, Ppn1p, is an essential vacuolar enzyme [ ]. It is a homodimer of chains of about 350 amino acids derived by proteolysis, from...

[ "GO:0000298", "GO:0005773", "GO:0016020" ]

[ "endopolyphosphatase activity", "vacuole", "membrane" ]

[ "molecular_function", "cellular_component", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF027093" ]

[ "EndopolyPtase_N1" ]

[ 1310 ]

1

[ "EC" ]

[ "3.6.1.10" ]

[ "EC:3.6.1.10" ]

1

[]

0

[ "PUB00016147" ]

[ "11447286" ]

[ "The endopolyphosphatase gene: essential in Saccharomyces cerevisiae." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1310 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Endopolyphosphatase, Ppn1p-related

EndopolyPtase_N1

5

IPR012361

12,361

Galactose-1-phosphate uridylyltransferase, short form, putative

GalT_short

Family

782

false

This group is related to , galactose-1-phosphate uridylyltransferases (GalT; ). is a member of the HIT domain superfamily based on structural fold [ ] and has a signature HXHXQ. Members of this group are shorter than members by ~100 residues, but have considerable sequence similarity, including the signature.

[]

0

[ "PIRSF" ]

[ "PIRSF031505" ]

[ "GalT_short" ]

[ 782 ]

1

[]

0

[ "4qvu" ]

1

[ "PUB00000405", "PUB00008005", "PUB00015645", "PUB00015708" ]

[ "7669762", "12119013", "2823224", "9063869" ]

[ "Three-dimensional structure of galactose-1-phosphate uridylyltransferase from Escherichia coli at 1.8 A resolution.", "Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.", "The nucleotide sequence o...

[ 1995, 2002, 1987, 1997 ]

4

[ "IPR001937" ]

[]

1

0

1

[ "Bacillati", "bioreactor metagenome" ]

[ 780, 2 ]

2

[]

0

true

Family

Galactose-1-phosphate uridylyltransferase, short form, putative

GalT_short

3

IPR012362

12,362

LytTR transmembrane transcriptional regulator, putative

LytTR_TM

Family

94

false

Members of this group combine an N-terminal domain with four transmembrane segments and a C-terminal LytTR DNA-binding domain [ ]. Accordingly, these proteins are predicted to be involved in transcriptional regulation and signal transduction, but their exact regulatory role or the mode of signal transduction as well as...

[]

0

[ "PIRSF" ]

[ "PIRSF031737" ]

[ "TM_LytTR" ]

[ 94 ]

1

[]

0

[]

0

[ "PUB00009981" ]

[ "12034833" ]

[ "A novel type of conserved DNA-binding domain in the transcriptional regulators of the AlgR/AgrA/LytR family." ]

[ 2002 ]

1

[]

0

null

[ "Alphaproteobacteria" ]

[ 94 ]

1

[]

0

true

Family

LytTR transmembrane transcriptional regulator, putative

LytTR_TM

2

IPR012363

12,363

L-threonine kinase

PduX

Family

2,049

false

Some bacteria, including Salmonella enterica subsp. enterica serovar Typhimurium, degrade 1,2-propanediol by a pathway that requires coenzyme B12, adenosylcobalamin (AdoCbl). Bacteria that harbour this pathway can use propanediol as a sole carbon and energy source. Proteins required for 1,2-propanediol degradation are ...

[]

0

[ "PIRSF" ]

[ "PIRSF033887" ]

[ "PduX" ]

[ 2049 ]

1

[]

0

[]

0

[ "PUB00011184", "PUB00015657", "PUB00101731" ]

[ "10498708", "12869542", "19509296" ]

[ "The propanediol utilization (pdu) operon of Salmonella enterica serovar Typhimurium LT2 includes genes necessary for formation of polyhedral organelles involved in coenzyme B(12)-dependent 1, 2-propanediol degradation.", "Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes.", "Kine...

[ 1999, 2003, 2009 ]

3

[]

0

null

[ "Bacteria", "Geodia barretti", "ecological metagenomes" ]

[ 2042, 1, 6 ]

3

[]

0

true

Family

L-threonine kinase

PduX

7

IPR012364

12,364

Oligosaccharide lyase

Oligosacch_lyase

Family

280

false

The Sphingomonas sp. A1 member of this group has been characterised as oligoalginate lyase [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF034409" ]

[ "Oligosach_lyase" ]

[ 280 ]

1

[]

0

[ "3a0o", "3afl" ]

2

[ "PUB00015977", "PUB00016006" ]

[ "10913091", "12729723" ]

[ "Molecular identification of oligoalginate lyase of Sphingomonas sp. strain A1 as one of the enzymes required for complete depolymerization of alginate.", "An exotype alginate lyase in Sphingomonas sp. A1: overexpression in Escherichia coli, purification, and characterization of alginate lyase IV (A1-IV)." ]

[ 2000, 2003 ]

2

[]

0

null

[ "Bacteria" ]

[ 280 ]

1

[]

0

true

Family

Oligosaccharide lyase

Oligosacch_lyase

7

IPR012365

12,365

Phosphoesterase, lmo2642-related

Pesteras_lmo2642

Family

515

false

This small family comprises proteins containing one copy of the metallophosphoesterase domain. They possess motifs characteristic of a variety of enzymatically active phosphoesterases [ ], including acid and alkaline phosphatases, phosphoprotein phosphatases, 5'-nucleotidase, bis(5'-nucleosyl)-tetraphosphatase (symmetr...

[]

0

[ "PIRSF" ]

[ "PIRSF034890" ]

[ "Pesteras_lmo2642" ]

[ 515 ]

1

[]

0

[ "2xmo" ]

1

[ "PUB00014394" ]

[ "8683579" ]

[ "Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 514, 1 ]

2

[]

0

true

Family

Phosphoesterase, lmo2642-related

Pesteras_lmo2642

5

IPR012367

12,367

Uncharacterised conserved protein thioesterase

UCP_Testerase

Family

90

false

This group is distantly related (sharing some sequence motifs) both to the integrated thioesterase domains (TEI) found in type I polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs), and to the related stand-alone (non-integrated) type II thioesterase (TEII; see for a full description). Therefore, ...

[]

0

[ "PIRSF" ]

[ "PIRSF036200" ]

[ "UCP_TEII" ]

[ 90 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Hyphomicrobiales" ]

[ 90 ]

1

[]

0

true

Family

Uncharacterised conserved protein thioesterase

UCP_Testerase

2

IPR012368

12,368

Oxidoreductase molybdopterin-binding subunit, IorB-related

OxRdtase_Mopterin-bd_su_IorB

Family

13,016

false

Isoquinoline 1-oxidoreductase (IOR, ), a heterodimer containing an alpha subunit (IorA) and a beta subunit (IorB; this group), belongs to a group of prokaryotic molybdenum-containing hydroxylases [ ]. The beta subunit is highly homologous to the membrane-bound aldehyde dehydrogenase (pyrroloquinoline-quinone, ) [ ]. It...

[]

0

[ "PIRSF" ]

[ "PIRSF036389" ]

[ "IOR_B" ]

[ 13016 ]

1

[]

0

[ "8gy3" ]

1

[ "PUB00015816", "PUB00016089" ]

[ "7782304", "2606906" ]

[ "Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases.", "Nucleotide sequence of the membrane-bound aldehyde dehydrogenase gene from Acetobacter polyoxogenes." ]

[ 1995, 1989 ]

2

[]

0

null

[ "Bacteria", "Halobacteriales", "Lasius niger", "unclassified sequences" ]

[ 12915, 3, 1, 97 ]

4

[]

0

true

Family

Oxidoreductase molybdopterin-binding subunit, IorB-related

OxRdtase_Mopterin-bd_su_IorB

6

IPR012369

12,369

Galactokinase, glycosyltransferase

Galk_glycosyltransferase

Family

601

false

Members of this family are predicted to be bifunctional enzymes.

[]

0

[ "PIRSF" ]

[ "PIRSF036399" ]

[ "Gal_kin_glcsltr" ]

[ 601 ]

1

[]

0

[]

0

[ "PUB00015644", "PUB00015669", "PUB00015675", "PUB00015730", "PUB00015835" ]

[ "11188689", "12771135", "8382990", "12001237", "12796487" ]

[ "Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.", "Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.", "Convergent evolution of similar enzymatic function on different protein ...

[ 2000, 2003, 1993, 2002, 2003 ]

5

[]

0

null

[ "Spermatophyta" ]

[ 601 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 4, 1 ]

3

true

Family

Galactokinase, glycosyltransferase

Galk_glycosyltransferase

6

IPR012371

12,371

Condensin-2 complex subunit D3

NCAPD3

Family

936

false

This group contains condensin-2 complex subunit D3. It is a regulatory subunit of the condensin-2 complex (contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2), a complex which establishes mitotic chromosome architecture and is involved in physica...

[ "GO:0007076", "GO:0000796" ]

[ "mitotic chromosome condensation", "condensin complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF036508" ]

[ "Condns_HCP-6" ]

[ 936 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-2299718", "R-HSA-2299718", "R-MMU-2299718" ]

[ "REACTOME:R-CEL-2299718", "REACTOME:R-HSA-2299718", "REACTOME:R-MMU-2299718" ]

3

[ "9f5w" ]

1

[ "PUB00056240", "PUB00100765" ]

[ "14532007", "27737959" ]

[ "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.", "Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis." ]

[ 2003, 2016 ]

2

[ "IPR026971" ]

[]

1

0

1

[ "Eukaryota" ]

[ 936 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 1, 1, 4, 3, 5, 3 ]

7

true

Family

Condensin-2 complex subunit D3

NCAPD3

2

IPR012372

12,372

Uncharacterised conserved protein UCP014405, metallopeptidase Zn-binding site

UCP014405_Zn-bd

Family

33

false

Members of this family contain a characteristic pattern of the Zn-binding site of neutral zinc metallopeptidases. Members of this family have not been characterised.

[]

0

[ "PIRSF" ]

[ "PIRSF014405" ]

[ "UCP014405" ]

[ 33 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Thermoprotei" ]

[ 33 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP014405, metallopeptidase Zn-binding site

UCP014405_Zn-bd

9

IPR012373

12,373

Fe(2+)-dicitrate sensor, transmembrane component

Ferrdict_sens_TM

Family

50,349

false

This family contains transmembrane signal transduction proteins involved in Fe2+ dicitrate sensing. Experimentally characterised members include Escherichia coli FecR [ ] and Pseudomonas putida PupR [ ]. Members of this family are a distinct group of anti-sigma factors [ ]. In E. coli, binding of ferric citrate to the ...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF018266", "PTHR30273" ]

[ "FecR", "" ]

[ 38639, 50347 ]

2

[]

0

[ "4m0h", "4m0n", "6ovk", "6ovm" ]

4

[ "PUB00015914", "PUB00015986", "PUB00016011", "PUB00016040", "PUB00016055", "PUB00016138", "PUB00062354" ]

[ "2254251", "8026465", "12534467", "9573190", "9891799", "10633096", "12354617" ]

[ "Novel two-component transmembrane transcription control: regulation of iron dicitrate transport in Escherichia coli K-12.", "Role for the outer membrane ferric siderophore receptor PupB in signal transduction across the bacterial cell envelope.", "Detection of multiple extracytoplasmic function (ECF) sigma fac...

[ 1990, 1994, 2002, 1998, 1998, 2000, 2002 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctfeV1", "unclassified sequences" ]

[ 49745, 39, 1, 564 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Fe(2+)-dicitrate sensor, transmembrane component

Ferrdict_sens_TM

4

IPR012374

12,374

Co/Fe-chelatase, CbiX-related

CbiX-rel

Family

14

false

This group represents proteins that contain an N-terminal CbiX (class II chelatase) domain, and an additional unique C-terminal domain of unknown function. This group of proteins is able to chelate both Fe 2+ and Co 2+ and can therefore act in both sirohaem and cobalamin biosynthesis [ ]. It functions primarily as a co...

[]

0

[ "PIRSF" ]

[ "PIRSF018636" ]

[ "CbiX_N-term" ]

[ 14 ]

1

[]

0

[ "2jh3" ]

1

[ "PUB00000554", "PUB00014361", "PUB00014383", "PUB00014675", "PUB00015809", "PUB00015833" ]

[ "9742226", "12686546", "10451360", "12196144", "12408752", "12917443" ]

[ "Cobalamin (vitamin B12) biosynthesis: functional characterization of the Bacillus megaterium cbi genes required to convert uroporphyrinogen III into cobyrinic acid a,c-diamide.", "A story of chelatase evolution: identification and characterization of a small 13-15-kDa \"ancestral\" cobaltochelatase (CbiXS) in th...

[ 1998, 2003, 1999, 2002, 2003, 2003 ]

6

[]

0

null

[ "Deinococcus" ]

[ 14 ]

1

[]

0

true

Family

Co/Fe-chelatase, CbiX-related

CbiX-rel

1

IPR012375

12,375

Glutamate synthase large subunit domain 1 stand-alone protein

Glu_synth_lsu_1

Family

585

false

The large (alpha, GltB) subunit of bacterial glutamate synthase (GOGAT, GltS) consists of three domains. This entry represents a stand-alone version of the N-terminal amidotransferase domain that is found in archaeal GOGAT, where the large subunit is represented by three separate proteins corresponding to the three dom...

[]

0

[ "PIRSF" ]

[ "PIRSF018774" ]

[ "GOGAT_lg_dom1" ]

[ 585 ]

1

[]

0

[]

0

[ "PUB00008698", "PUB00013982", "PUB00015710" ]

[ "11967268", "11188694", "11230537" ]

[ "Structural studies on the synchronization of catalytic centers in glutamate synthase.", "Cross-talk and ammonia channeling between active centers in the unexpected domain arrangement of glutamate synthase.", "Phylogenetic analyses of two \"archaeal\" genes in thermotoga maritima reveal multiple transfers betwe...

[ 2002, 2000, 2001 ]

3

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 163, 415, 7 ]

3

[]

0

true

Family

Glutamate synthase large subunit domain 1 stand-alone protein

Glu_synth_lsu_1

7

IPR012379

12,379

LytTR MHYE transcriptional regulator, putative

LytTR_MHYE

Family

738

false

Members of this group combine the LytTR DNA-binding transcriptional regulator domain [ ] with an N-terminal membrane-bound MHYE domain that consists of three predicted transmembrane segments with conserved Glu, Asp, His and Tyr residues. The membrane topology of this domain is somewhat similar to that of MHYT domain [ ...

[]

0

[ "PIRSF" ]

[ "PIRSF031767" ]

[ "MHYE_LytTR" ]

[ 738 ]

1

[]

0

[]

0

[ "PUB00009981", "PUB00015987", "PUB00016193" ]

[ "12034833", "10784047", "11728710" ]

[ "A novel type of conserved DNA-binding domain in the transcriptional regulators of the AlgR/AgrA/LytR family.", "Novel genes involved in the regulation of pathogenicity factor production within the rpf gene cluster of Xanthomonas campestris.", "MHYT, a new integral membrane sensor domain." ]

[ 2002, 2000, 2001 ]

3

[ "IPR046947" ]

[]

1

0

1

[ "Knufia peltigerae", "Pseudomonadota", "ecological metagenomes" ]

[ 1, 731, 6 ]

3

[]

0

true

Family

LytTR MHYE transcriptional regulator, putative

LytTR_MHYE

5

IPR012381

12,381

Ethanolamine/propanediol utilisation protein, EutP/PduV

EutP_PduV

Family

3,064

false

Members of this family function in ethanolamine [ , ] and propanediol [ ] degradation pathways. Both pathways require coenzyme B12 (adenosylcobalamin, AdoCbl). Bacteria that harbour these pathways can use ethanolamine as a source of carbon and nitrogen, or propanediol as a sole carbon and energy source, respectively. T...

[ "GO:0005524", "GO:0006576" ]

[ "ATP binding", "biogenic amine metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PF10662", "PIRSF036409", "PTHR40453", "TIGR02528" ]

[ "PduV-EutP", "EutP_PduV", "", "EutP" ]

[ 3059, 2626, 2914, 1998 ]

4

[ "GP", "GP" ]

[ "GenProp0292", "GenProp1762" ]

[ "GP:GenProp0292", "GP:GenProp1762" ]

2

[]

0

[ "PUB00009955", "PUB00011184", "PUB00013592", "PUB00013631", "PUB00014695", "PUB00014697", "PUB00014699", "PUB00014701", "PUB00096913" ]

[ "10464203", "10498708", "9023178", "8226666", "1312999", "1313000", "9539791", "9922242", "26448059" ]

[ "The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins.", "The propanediol utilization (pdu) operon of Salmonella enterica serovar Typhimurium LT2 includes genes necessary for formation of polyhedral organelles involved in coenzyme B(12)-dependent 1,...

[ 1999, 1999, 1997, 1993, 1992, 1992, 1998, 1999, 2016 ]

9

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3021, 24, 19 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Ethanolamine/propanediol utilisation protein, EutP/PduV

EutP_PduV

8

IPR012382

12,382

Precorrin-2 C(20)-methyltransferase

CobI/CbiL

Family

10,910

false

This entry represents precorrin-2 C20-methyltransferase CobI/CbiL ( ), which introduces a methyl group at C-20 on precorrin-2 to produce precorrin-3A during cobalamin biosynthesis (vitamin B12). This reaction is key to the conversion of a porphyrin-type tetrapyrrole ring to a corrin ring [ ]. In some species, this enzy...

[ "GO:0008757", "GO:0030788", "GO:0009236" ]

[ "S-adenosylmethionine-dependent methyltransferase activity", "precorrin-2 C20-methyltransferase activity", "cobalamin biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF", "CDD" ]

[ "PIRSF036427", "cd11645" ]

[ "Precrrn-2_mtase", "Precorrin_2_C20_MT" ]

[ 8564, 10902 ]

2

[ "EC", "METACYC" ]

[ "2.1.1.130", "PWY-7376" ]

[ "EC:2.1.1.130", "METACYC:PWY-7376" ]

2

[ "2e0k", "2e0n", "2qbu", "8xj3" ]

4

[ "PUB00035497" ]

[ "17229157" ]

[ "Crystal structures of CbiL, a methyltransferase involved in anaerobic vitamin B biosynthesis, and CbiL in complex with S-adenosylhomocysteine--implications for the reaction mechanism." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 588, 10221, 7, 94 ]

4

[]

0

true

Family

Precorrin-2 C(20)-methyltransferase

CobI/CbiL

5

IPR012383

12,383

Uroporphyrin-III C-methyltransferase, plant

Uropor_MeTrfase_pln

Family

6

false

Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT), an enzyme of the sirohaem and cobalamin biosynthetic pathway, catalyses C methylation of uroporphyrinogen III ( ) [ , ]. It transfers two methyl groups from S-adenosyl-L-methionine to the C-2 and C-7 atoms of ur...

[ "GO:0004851" ]

[ "uroporphyrin-III C-methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF036478" ]

[ "Uropor_mtas_plnt" ]

[ 6 ]

1

[]

0

[]

0

[ "PUB00002147", "PUB00002148", "PUB00006363" ]

[ "1856165", "1906874", "9006913" ]

[ "Purification, characterization, and molecular cloning of S-adenosyl-L-methionine: uroporphyrinogen III methyltransferase from Methanobacterium ivanovii.", "Primary structure, expression in Escherichia coli, and properties of S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase from Bacillus megaterium....

[ 1991, 1991, 1997 ]

3

[]

0

null

[ "Mesangiospermae" ]

[ 6 ]

1

[ "Arabidopsis thaliana", "Zea mays" ]

[ 1, 4 ]

2

true

Family

Uroporphyrin-III C-methyltransferase, plant

Uropor_MeTrfase_pln

6

IPR012385

12,385

Prephenate dehydrogenase, fungal

Prephenate_DH_fun

Family

1,364

false

Members of this group catalyse a step in tyrosine biosynthesis in the shikimate pathway, which is present only in bacteria, archaea, fungi, and plants [ ]. They belong to the prephenate dehydrogenase (PDH) domain superfamily . Many of the PDH enzymes are able to use the alternative intermediates of tyrosine biosynthesi...

[]

0

[ "PIRSF" ]

[ "PIRSF036510" ]

[ "PDH_fung" ]

[ 1364 ]

1

[]

0

[]

0

[ "PUB00011044", "PUB00011046", "PUB00015637", "PUB00015943", "PUB00016002", "PUB00016053" ]

[ "12354106", "2123197", "11476485", "2697638", "3556217", "6060189" ]

[ "Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana.", "A single cyclohexadienyl dehydrogenase specifies the prephenate dehydrogenase and arogenate dehydrogenase components of the dual pathways to L-tyrosine in Pseudomonas aeruginosa.", "The biosynt...

[ 2002, 1990, 2001, 1989, 1987, 1967 ]

6

[]

0

null

[ "Fungi" ]

[ 1364 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Family

Prephenate dehydrogenase, fungal

Prephenate_DH_fun

6

IPR012386

12,386

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Cyclic-nucl_3Pdiesterase

Family

2,213

false

2',3' Cyclic nucleotide phosphodiesterases (CPDases) are enzymes that catalyse at least two distinct steps in the splicing of tRNA introns in eukaryotes. The active site is characterised by two conserved histidine residues [ ]. The enzyme has six cysteine residues, four of which are involved in forming two intra-molecu...

[ "GO:0004112" ]

[ "cyclic-nucleotide phosphodiesterase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF07823", "PIRSF017903", "PTHR28141" ]

[ "CPDase", "CPDase_plant", "" ]

[ 1546, 446, 2111 ]

3

[ "EC" ]

[ "3.1.4.37" ]

[ "EC:3.1.4.37" ]

1

[ "1fsi", "1jh6", "1jh7" ]

3

[ "PUB00013260", "PUB00013642" ]

[ "11694509", "12466548" ]

[ "Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana.", "Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 18, 195, 1975, 25 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 7, 1, 4, 1, 1, 8 ]

6

true

Family

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Cyclic-nucl_3Pdiesterase

8

IPR012387

12,387

tRNA ligase Trl1, fungi

Trl1_fun

Family

1,265

false

Budding yeast Trl1 is a tRNA ligase required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the unfolded protein response [ ]. Trl1 has phosphodiesterase, polynucleotide kinase, and ligase activities [ , , ].

[ "GO:0003972", "GO:0005524", "GO:0008081", "GO:0051730", "GO:0006388" ]

[ "RNA ligase (ATP) activity", "ATP binding", "phosphoric diester hydrolase activity", "GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "tRNA splicing, via endonucleolytic cleavage and ligation" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

5

[ "PIRSF" ]

[ "PIRSF019634" ]

[ "tRNA_lig_yeast" ]

[ 1265 ]

1

[ "EC" ]

[ "6.5.1.3" ]

[ "EC:6.5.1.3" ]

1

[]

0

[ "PUB00075556", "PUB00075558", "PUB00075559", "PUB00075560" ]

[ "20844078", "6297798", "8428918", "3277966" ]

[ "Dual functions of yeast tRNA ligase in the unfolded protein response: unconventional cytoplasmic splicing of HAC1 pre-mRNA is not sufficient to release translational attenuation.", "Mechanism of action of a yeast RNA ligase in tRNA splicing.", "Novel activity of a yeast ligase deletion polypeptide. Evidence fo...

[ 2010, 1983, 1993, 1988 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1265 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

tRNA ligase Trl1, fungi

Trl1_fun

2

IPR012388

12,388

CDK5 and ABL1 enzyme substrate 1/2

CABLES1/2

Family

3,867

false

This group represents protein CABLES (CDK5 and ABL1 enzyme substrate), including CABLES1 and CABLES2 [ , ]. CABLES1 is a cyclin-dependent kinase binding protein, primarily involved in cell cycle regulation [ ]. CABLES1 binds to different functional domains of p53 and p73 and modifies their cell death-inducing activitie...

[ "GO:0051726" ]

[ "regulation of cell cycle" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF025798", "PTHR22896" ]

[ "Cables", "" ]

[ 2287, 3867 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-69202", "R-HSA-69656", "R-HSA-983231", "R-MMU-69202", "R-MMU-69656" ]

[ "REACTOME:R-HSA-69202", "REACTOME:R-HSA-69656", "REACTOME:R-HSA-983231", "REACTOME:R-MMU-69202", "REACTOME:R-MMU-69656" ]

5

[]

0

[ "PUB00015978", "PUB00016076", "PUB00033517", "PUB00073479", "PUB00073756" ]

[ "10896159", "14729625", "11706030", "14637168", "18059193" ]

[ "Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.", "Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer.", "Differential effect of ik3-1/cables on...

[ 2000, 2004, 2002, 2003, 2008 ]

5

[]

0

null

[ "Eukaryota" ]

[ 3867 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 8, 4, 7, 7, 6 ]

6

true

Family

CDK5 and ABL1 enzyme substrate 1/2

CABLES1/2

4

IPR012389

12,389

Cyclin P/U

Cyclin_P/U

Family

2,432

false

This entry represents a group of plant and fungi cyclins belonging to the P/U family. They interact preferentially with CDKA1 [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF027110" ]

[ "PREG" ]

[ 2432 ]

1

[]

0

[]

0

[ "PUB00055074" ]

[ "15197472" ]

[ "Molecular characterization of Arabidopsis PHO80-like proteins, a novel class of CDKA;1-interacting cyclins." ]

[ 2004 ]

1

[ "IPR013922" ]

[]

1

0

1

[ "Coxiella burnetii", "Eukaryota" ]

[ 2, 2430 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 25, 6, 1, 4 ]

4

true

Family

Cyclin P/U

Cyclin_P/U

7

IPR012390

12,390

Phosphoesterase SP1827

Pesterase_SP1827

Family

197

false

This entry represents a family of proteobacteria type predicted phosphoesterases [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF033949" ]

[ "Phosest_Mlr3352" ]

[ 197 ]

1

[]

0

[ "2fsq" ]

1

[ "PUB00013642" ]

[ "12466548" ]

[ "Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria" ]

[ 197 ]

1

[]

0

true

Family

Phosphoesterase SP1827

Pesterase_SP1827

2

IPR012391

12,391

Serine/threonine protein phosphatase, BSU1

Ser/Thr_prot_Pase_BSU1

Family

2,085

false

This entry represents a group of plant serine/threonine protein phosphatases, including Arabidopsis BSU1 and BSU1-like proteins (BSLs) [ ]. AtBSU1 is a phosphatase that acts as a positive regulator of brassinosteroid (BR) signalling [ , ]. This entry also includes putative serine/threonine-protein phosphatases from Pla...

[ "GO:0004721", "GO:0009742" ]

[ "phosphoprotein phosphatase activity", "brassinosteroid mediated signaling pathway" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF036363" ]

[ "PPP_BSU1" ]

[ 2085 ]

1

[ "EC" ]

[ "3.1.3.16" ]

[ "EC:3.1.3.16" ]

1

[]

0

[ "PUB00016049", "PUB00073510" ]

[ "14977918", "21855796" ]

[ "Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis.", "The CDG1 kinase mediates brassinosteroid signal transduction from BRI1 receptor kinase to BSU1 phosphatase and GSK3-like kinase BIN2." ]

[ 2004, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2085 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 20, 7, 27 ]

3

true

Family

Serine/threonine protein phosphatase, BSU1

Ser/Thr_prot_Pase_BSU1

9

IPR012392

12,392

Very-long-chain 3-ketoacyl-CoA synthase

3-ktacl-CoA_syn

Family

13,540

false

This group represents 3-ketoacyl-CoA synthases (KCSs) from plants [ , ]. They are also known as very long-chain fatty acid (VLCFA) condensing enzymes, and they catalyse the first committed step during the fatty acid elongation process, which is the condensation of C2 units to acyl-CoA. Arabidopsis contains 21 KCS membe...

[ "GO:0016747", "GO:0006633", "GO:0016020" ]

[ "acyltransferase activity, transferring groups other than amino-acyl groups", "fatty acid biosynthetic process", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF036417", "PTHR31561" ]

[ "3-ktacl-CoA_syn", "" ]

[ 10364, 13540 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.1.199", "PWY-5080", "PWY-5972", "PWY-6433", "PWY-6598", "PWY-7035", "PWY-7036", "PWY-7601", "PWY-7602", "PWY-7619", "PWY-7724", "PWY-7725", "PWY-8041" ]

[ "EC:2.3.1.199", "METACYC:PWY-5080", "METACYC:PWY-5972", "METACYC:PWY-6433", "METACYC:PWY-6598", "METACYC:PWY-7035", "METACYC:PWY-7036", "METACYC:PWY-7601", "METACYC:PWY-7602", "METACYC:PWY-7619", "METACYC:PWY-7724", "METACYC:PWY-7725", "METACYC:PWY-8041" ]

13

[ "9uu3", "9uu4", "9uu5" ]

3

[ "PUB00015963", "PUB00073455", "PUB00073456" ]

[ "10330468", "18465198", "23585652" ]

[ "CUT1, an Arabidopsis gene required for cuticular wax biosynthesis and pollen fertility, encodes a very-long-chain fatty acid condensing enzyme.", "The VLCFA elongase gene family in Arabidopsis thaliana: phylogenetic analysis, 3D modelling and expression profiling.", "Arabidopsis 3-ketoacyl-coenzyme a synthase9...

[ 1999, 2008, 2013 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 13535 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 85, 78, 102 ]

3

true

Family

Very-long-chain 3-ketoacyl-CoA synthase

3-ktacl-CoA_syn

8

IPR012394

12,394

Aldehyde dehydrogenase NAD(P)-dependent

Aldehyde_DH_NAD(P)

Family

32,029

false

Aldehydes are produced as intermediates during the metabolism of many different compounds including amino acids, carbohydrates, lipids vitamins and steroids [ ]. They are highly reactive compounds whose buildup to excess levels can cause cytotoxic, genotoxic and carcinogenic effects. Aldehyde dehydrogenases oxidise the...

[ "GO:0006081" ]

[ "aldehyde metabolic process" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF036492", "PTHR43570" ]

[ "ALDH", "" ]

[ 27534, 27709 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "1.2.1", "R-BTA-6798695", "R-BTA-9845614", "R-CFA-211945", "R-DDI-211945", "R-DDI-389599", "R-DDI-6798695", "R-DDI-9603798", "R-DDI-9609523", "R-DDI-9845614", "R-HSA-211945", "R-HSA-389599", "R-HSA-6798695", "R-HSA-9603798", "R-HSA-9609523", "R-HSA-9696270", "R-HSA-9696273", "R-HSA...

[ "EC:1.2.1", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9845614", "REACTOME:R-CFA-211945", "REACTOME:R-DDI-211945", "REACTOME:R-DDI-389599", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-9603798", "REACTOME:R-DDI-9609523", "REACTOME:R-DDI-9845614", "REACTOME:R-HSA-211945", "REACTOME:R-HSA-389599", ...

43

[ "1ad3", "3sza", "3szb", "3ty7", "4a0m", "4h80", "4l1o", "4l2o", "4qgk", "4v3f", "5a2d", "5myp", "5nno", "5ucd", "6k0z", "6k10", "6qhn", "8bb8", "9nxl" ]

19

[ "PUB00023323", "PUB00033217", "PUB00088401", "PUB00088404" ]

[ "9095201", "11154732", "15933032", "18627463" ]

[ "The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold.", "Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism.", "Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde.", "The ylo-1 gene encodes an aldehy...

[ 1997, 2000, 2005, 2008 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 17069, 14509, 170, 1, 280 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 18, 5, 15, 13, 48, 22, 1, 21, 27, 1, 33 ]

11

true

Family

Aldehyde dehydrogenase NAD(P)-dependent

Aldehyde_DH_NAD(P)

7

IPR012395

12,395

IGFBP-related, CNN

IGFBP_CNN

Family

4,640

false

This entry represents a group of IGFBP (insulin-like growth fac- tor (IGF) binding proteins)-related proteins, which have been annotated as the CNN family [ , ]. Members of the CCN family are composed of an N-terminal secretory signal peptide followed by four conserved domains with homology to insulin-like growth facto...

[]

0

[ "PIRSF" ]

[ "PIRSF036495" ]

[ "IGFBP_rP_CNN" ]

[ 4640 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-381426", "R-GGA-8957275", "R-HSA-2032785", "R-HSA-381426", "R-HSA-8951671", "R-HSA-8957275", "R-MMU-381426", "R-MMU-8957275", "R-RNO-381426", "R-RNO-8957275" ]

[ "REACTOME:R-GGA-381426", "REACTOME:R-GGA-8957275", "REACTOME:R-HSA-2032785", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8951671", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275", "REACTOME:R-RNO-381426", "REACTOME:R-RNO-8957275" ]

10

[]

0

[ "PUB00014624", "PUB00091690", "PUB00091692", "PUB00091693" ]

[ "9745429", "11584015", "11782444", "12695522" ]

[ "Recommendations for nomenclature of the insulin-like growth factor binding protein superfamily.", "The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.", "WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.", ...

[ 1998, 2001, 2002, 2003 ]

4

[]

0

null

[ "Kangiella spongicola", "Vertebrata" ]

[ 1, 4639 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 16, 8, 13 ]

4

true

Family

IGFBP-related, CNN

IGFBP_CNN

4

IPR012397

12,397

Pullulan 6-glucanohydrolase

Pullulanase

Family

269

false

This group represents a pullulan 6-glucanohydrolase.

[]

0

[ "PIRSF" ]

[ "PIRSF012560" ]

[ "Pullulanase" ]

[ 269 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 269 ]

1

[]

0

true

Family

Pullulan 6-glucanohydrolase

Pullulanase

4

IPR012398

12,398

PRIB5

Family

706

false

This group represents a predicted PRIB5 protein.

[]

0

[ "PIRSF" ]

[ "PIRSF015897" ]

[ "PRIB5" ]

[ 706 ]

1

[]

0

[]

0

[]

0

[ "IPR013078" ]

[]

1

0

1

[ "Embryophyta" ]

[ 706 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 19, 2, 2 ]

3

true

Family

PRIB5

3

IPR012399

12,399

Cyclin Y

Cyclin_Y

Family

3,327

false

Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [ ], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essenti...

[ "GO:0019901", "GO:0000079" ]

[ "protein kinase binding", "regulation of cyclin-dependent protein serine/threonine kinase activity" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF028934" ]

[ "Cyclin_CG14939" ]

[ 3327 ]

1

[]

0

[]

0

[ "PUB00014101", "PUB00014103", "PUB00055079", "PUB00055081" ]

[ "11056549", "12910258", "19524571", "20059949" ]

[ "Cyclin' on the viral path to destruction.", "Cell cycle regulation and neural differentiation.", "Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1.", "Cell cycle control of wnt receptor activation." ]

[ 2000, 2003, 2009, 2009 ]

4

[]

0

null

[ "Eukaryota" ]

[ 3327 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 1, 5, 2, 6 ]

6

true

Family

Cyclin Y

Cyclin_Y

4

IPR012400

12,400

Long-chain-alcohol oxidase

Long_Oxdase

Family

3,197

false

The long-chain alcohol oxidase (FAO) acts as the second enzyme in the omega-oxidation pathway of lipid degradation in yeast [ , ]. Four homologues have been described in Arabidopsis thaliana: AtFAO1, AtFAO3, AtAFO4a, and AtFAO4b [ ].

[ "GO:0046577" ]

[ "long-chain-alcohol oxidase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF028937" ]

[ "Lg_Ch_AO" ]

[ 3197 ]

1

[ "EC", "METACYC" ]

[ "1.1.3.20", "PWY-2724" ]

[ "EC:1.1.3.20", "METACYC:PWY-2724" ]

2

[]

0

[ "PUB00073593", "PUB00073594", "PUB00073596" ]

[ "10660617", "15358540", "16046182" ]

[ "A consensus sequence for long-chain fatty-acid alcohol oxidases from Candida identifies a family of genes involved in lipid omega-oxidation in yeast with homologues in plants and bacteria.", "Functional identification of AtFao3, a membrane bound long chain alcohol oxidase in Arabidopsis thaliana.", "Candida ye...

[ 2000, 2004, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 219, 2974, 4 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 19, 1, 14, 14 ]

4

true

Family

Long-chain-alcohol oxidase

Long_Oxdase

4

IPR012401

12,401

DNA-binding protein MutS2, archaea

DNA-bd_MutS2_arc

Family

527

false

MutS2 from archaea has ATPase and non-specific DNA-binding activities. It does not have any detectable mismatch-specific DNA binding activity [ ].

[]

0

[ "HAMAP", "PIRSF" ]

[ "MF_00971", "PIRSF029254" ]

[ "MutS2_archaea", "MutS_C_archaeal" ]

[ 506, 526 ]

2

[]

0

[]

0

[ "PUB00069564" ]

[ "11821933" ]

[ "MutS2 family protein from Pyrococcus furiosus." ]

[ 2002 ]

1

[ "IPR045076" ]

[]

1

0

1

[ "Archaea", "ecological metagenomes" ]

[ 524, 3 ]

2

[]

0

true

Family

DNA-binding protein MutS2, archaea

DNA-bd_MutS2_arc

7

IPR012404

12,404

Nucleotide-sugar transporter-related

UCP036436

Family

2,469

false

This entry represents a predicted permease related to nucleotide-sugar transporters. Proteins in this entry include solute carrier family 35 member F6 (SLC35F6, also known as C2orf18) from humans and PH domain-containing rcdII from Dictyostelium discoideum. SLC35F6 is involved in the maintenance of mitochondrial membra...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PIRSF" ]

[ "PIRSF036436" ]

[ "UCP036436" ]

[ 2469 ]

1

[]

0

[]

0

[ "PUB00066821" ]

[ "19154410" ]

[ "Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis." ]

[ 2009 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2469 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 1, 3, 1, 4, 1 ]

8

true

Family

Nucleotide-sugar transporter-related

UCP036436

7

IPR012405

12,405

LytTR stand-alone protein

LyTR_stand-alone

Family

18

false

Members of this group are stand-alone forms of the LytTR DNA-binding domain [ ]. One of them is BlpS from Streptococcus pneumoniae. BlpS is encoded together with the components of the two-component system Blp, which also contains another LytTR-containing protein, the response regulator BlpR [ ]. The Blp system is close...

[]

0

[ "PIRSF" ]

[ "PIRSF033143" ]

[ "LytTR_solo" ]

[ 18 ]

1

[]

0

[]

0

[ "PUB00009981", "PUB00015819" ]

[ "12034833", "10940007" ]

[ "A novel type of conserved DNA-binding domain in the transcriptional regulators of the AlgR/AgrA/LytR family.", "Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide." ]

[ 2002, 2000 ]

2

[ "IPR046947" ]

[]

1

0

1

[ "Streptococcus" ]

[ 18 ]

1

[]

0

true

Family

LytTR stand-alone protein

LyTR_stand-alone

1

IPR012406

12,406

Urease accessory protein UreE

UreE

Family

7,570

false

Urease and other nickel metalloenzymes are synthesised as precursors devoid of the metalloenzyme active site. These precursors then undergo a complex post-translational maturation process that requires a number of accessory proteins. Members of this group are nickel-binding proteins required for urease metallocentre as...

[ "GO:0016151", "GO:0006457", "GO:0005737" ]

[ "nickel cation binding", "protein folding", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PIRSF", "CDD" ]

[ "MF_00822", "PIRSF036402", "cd00571" ]

[ "UreE", "Ureas_acces_UreE", "UreE" ]

[ 7288, 5712, 6277 ]

3

[]

0

[ "1ear", "1eb0", "1gmu", "1gmv", "1gmw", "3l9z", "3la0", "3nxz", "3ny0", "3tj8", "3tj9", "3tja", "4l3k" ]

13

[ "PUB00015648", "PUB00015660", "PUB00015688", "PUB00015735", "PUB00015770", "PUB00015786", "PUB00015811", "PUB00015843", "PUB00015858" ]

[ "12072968", "11591723", "11602602", "8808929", "11157956", "10753863", "12388207", "8318889", "7721685" ]

[ "Molecular characterization of Bacillus pasteurii UreE, a metal-binding chaperone for the assembly of the urease active site.", "Crystal structure of Klebsiella aerogenes UreE, a nickel-binding metallochaperone for urease activation.", "Structural basis for Ni(2+) transport and assembly of the urease active sit...

[ 2002, 2001, 2001, 1996, 2001, 2000, 2003, 1993, 1995 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 121, 7378, 2, 69 ]

4

[]

0

true

Family

Urease accessory protein UreE

UreE

7

IPR012408

12,408

Acetaldehyde/propionaldehyde dehydrogenase, EutE/PduP-related

Acetald_propionald_DH-rel

Family

2,890

false

Members of this group function in ethanolamine [ , ] and propanediol [ ] degradation pathways. Both pathways require coenzyme B12 (adenosylcobalamin, AdoCbl). Bacteria that harbor these pathways can use ethanolamine as a source of carbon and nitrogen, or propanediol as a sole carbon and energy source, respectively. The...

[ "GO:0008774" ]

[ "acetaldehyde dehydrogenase (acetylating) activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "PIRSF", "CDD" ]

[ "NF011927", "PIRSF036410", "cd07121" ]

[ "PRK15398.1", "EutE_PduP", "ALDH_EutE" ]

[ 2885, 2740, 2533 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.2.1.10", "PWY-5162", "PWY-5436", "PWY-5480", "PWY-6587", "PWY-7085", "PWY-7180", "PWY-8060", "PWY-8062" ]

[ "EC:1.2.1.10", "METACYC:PWY-5162", "METACYC:PWY-5436", "METACYC:PWY-5480", "METACYC:PWY-6587", "METACYC:PWY-7085", "METACYC:PWY-7180", "METACYC:PWY-8060", "METACYC:PWY-8062" ]

9

[ "4c3s", "5dbv", "5dru", "5jfl", "5jfm", "5jfn", "6gvs" ]

7

[ "PUB00002263", "PUB00009955", "PUB00011184", "PUB00013592", "PUB00013631", "PUB00013632", "PUB00014695", "PUB00014696", "PUB00014700", "PUB00014701", "PUB00097928" ]

[ "7868611", "10464203", "10498708", "9023178", "8226666", "8770581", "1312999", "2656649", "1328159", "9922242", "27450681" ]

[ "Ethanolamine utilization in Salmonella typhimurium: nucleotide sequence, protein expression, and mutational analysis of the cchA cchB eutE eutJ eutG eutH gene cluster.", "The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins.", "The propanediol ut...

[ 1995, 1999, 1999, 1997, 1993, 1996, 1992, 1989, 1992, 1999, 2016 ]

11

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2872, 4, 14 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Acetaldehyde/propionaldehyde dehydrogenase, EutE/PduP-related

Acetald_propionald_DH-rel

6

IPR012409

12,409

Sirohaem synthase

Sirohaem_synth

Family

10,464

false

Sirohaem synthase (CysG), a multifunctional enzyme of the sirohaem and cobalamin (vitamin B12) biosynthesis pathways, represents a fusion between uroporphyrin-III C-methyltransferase (SUMT) and precorrin-2 oxidase/chelatase. Therefore, in some bacteria, all four reactions of sirohaem biosynthesis are catalysed by one m...

[ "GO:0004851", "GO:0043115", "GO:0051266", "GO:0051287", "GO:0009236", "GO:0019354" ]

[ "uroporphyrin-III C-methyltransferase activity", "precorrin-2 dehydrogenase activity", "sirohydrochlorin ferrochelatase activity", "NAD binding", "cobalamin biosynthetic process", "siroheme biosynthetic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

6

[ "HAMAP", "PIRSF" ]

[ "MF_01646", "PIRSF036426" ]

[ "Siroheme_synth", "Sirohaem_synth" ]

[ 4814, 10455 ]

2

[ "EC", "EC", "EC", "METACYC", "METACYC", "METACYC" ]

[ "1.3.1.76", "2.1.1.107", "4.99.1.4", "PWY-5194", "PWY-5196", "PWY-7377" ]

[ "EC:1.3.1.76", "EC:2.1.1.107", "EC:4.99.1.4", "METACYC:PWY-5194", "METACYC:PWY-5196", "METACYC:PWY-7377" ]

6

[ "1pjq", "1pjs", "1pjt", "6p5x", "6p5z", "6p7c", "6p7d", "6pqz", "6pr0", "6pr1", "6pr2", "6pr3", "6pr4", "6ulu", "6veb" ]

15

[ "PUB00006361", "PUB00014361", "PUB00014379", "PUB00014459", "PUB00014667", "PUB00014702", "PUB00014703", "PUB00015677", "PUB00015704", "PUB00015809", "PUB00015833", "PUB00015848" ]

[ "8905078", "12686546", "9150215", "11980703", "12196148", "10051442", "9461500", "8243665", "8955319", "12408752", "12917443", "7945210" ]

[ "Cobalamin (coenzyme B12): synthesis and biological significance.", "A story of chelatase evolution: identification and characterization of a small 13-15-kDa \"ancestral\" cobaltochelatase (CbiXS) in the archaea.", "A role for Salmonella typhimurium cbiK in cobalamin (vitamin B12) and siroheme biosynthesis.", ...

[ 1996, 2003, 1997, 2002, 2002, 1999, 1998, 1993, 1996, 2003, 2003, 1994 ]

12

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10288, 93, 83 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Sirohaem synthase

Sirohaem_synth

1

IPR012410

12,410

Nucleoside-diphosphate kinase-like NDK-H5

NDK_H5

Family

545

false

This family contains homologues of nucleoside diphosphate kinases (NDPKs). They are designated NDP kinase homologue 5 (NDK-H5), and differ from other NDPKs by having a C-terminal Dpy-30 motif. Despite considerable sequence similarity to other NDPKs, and conservation of seven out of nine known functionally important res...

[ "GO:0048515" ]

[ "spermatid differentiation" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF036504" ]

[ "NDK_H5" ]

[ 545 ]

1

[]

0

[ "8j07", "8wzb", "8x2u", "9fqr" ]

4

[ "PUB00014705", "PUB00014706", "PUB00014707", "PUB00014708" ]

[ "12788088", "8747457", "9742940", "7669763" ]

[ "Cloning, sequencing, and characterization of the murine nm23-M5 gene during mouse spermatogenesis and spermiogenesis.", "X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution.", "A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells.", "M...

[ 2003, 1995, 1998, 1995 ]

4

[ "IPR001564" ]

[]

1

0

1

[ "Bilateria" ]

[ 545 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 2 ]

4

true

Family

Nucleoside-diphosphate kinase-like NDK-H5

NDK_H5

5

IPR012413

12,413

BA14k family

BA14K

Family

3,894

false

BA14K is strongly immunoreactive; it induces both humoral and cellular responses in hosts throughout the infective process [ ]. It has lectin-like properties, and may play a role in the synthesis of smooth lipopolysaccharide [ ].

[]

0

[ "PFAM" ]

[ "PF07886" ]

[ "BA14K" ]

[ 3894 ]

1

[]

0

[]

0

[ "PUB00016541", "PUB00067862" ]

[ "9673296", "16368972" ]

[ "Identification and characterization of a 14-kilodalton Brucella abortus protein reactive with antibodies from naturally and experimentally infected hosts and T lymphocytes from experimentally infected BALB/c mice.", "Role in virulence of a Brucella abortus protein exhibiting lectin-like activity." ]

[ 1998, 2006 ]

2

[]

0

null

[ "Bacteria", "Darwinula stevensoni", "ecological metagenomes" ]

[ 3889, 1, 4 ]

3

[]

0

true

Family

BA14k family

BA14K

7

IPR012414

12,414

BDS potassium channel toxin

BDS_K_chnl_tox

Family

95

false

This entry represents the sea anemone type 3 (BDS) potassium channel toxins. Family members include toxin APETx1 and 2 [ , ], and the antihypertensive and antiviral proteins BDS-I ( ) [[cite~:22442564]] and BDS-II ( ) [ ] expressed by Anemonia sulcata. BDS-I is organised into a triple-stranded antiparallel β-sheet, wit...

[ "GO:0008200", "GO:0090729", "GO:0042151" ]

[ "ion channel inhibitor activity", "toxin activity", "nematocyst" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PFAM" ]

[ "PF07936" ]

[ "Defensin_4" ]

[ 95 ]

1

[]

0

[ "1bds", "1wqk", "1wxn", "2bds", "2mub", "7bwi" ]

6

[ "PUB00016411", "PUB00016458", "PUB00097236", "PUB00097237", "PUB00097238", "PUB00097239" ]

[ "9506974", "2566326", "17473056", "28796463", "25337890", "16177043" ]

[ "Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4.", "Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid...

[ 1998, 1989, 2007, 2017, 2014, 2005 ]

6

[]

0

null

[ "Colwellia maritima", "Hexacorallia" ]

[ 1, 94 ]

2

[]

0

true

Family

BDS potassium channel toxin

BDS_K_chnl_tox

9

IPR012415

12,415

Restriction endonuclease, type II, Cfr10I/Bse634I

Restrct_endonuc_II_Cfr10I

Family

55

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[]

0

[ "PFAM" ]

[ "PF07832" ]

[ "Bse634I" ]

[ 55 ]

1

[]

0

[ "1cfr", "1knv", "3dpg", "3dvo", "3dw9", "3mq6", "3mqy", "3n78", "3n7b", "3v1z", "3v20", "3v21", "4c3g", "6obj", "7s8d", "7ss5", "9bgi", "9bgj" ]

18

[ "PUB00016389", "PUB00023942", "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "11842098", "8568865", "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence.", "Crystal structure of Citrobacter freundii restriction endonuclease Cfr10I at 2.15 A resolution.", "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II res...

[ 2002, 1996, 2005, 2003, 2002, 2001, 2004, 2003 ]

8

[]

0

null

[ "Bacteria", "candidate division MSBL1 archaeon SCGC-AAA259M10" ]

[ 54, 1 ]

2

[]

0

true

Family

Restriction endonuclease, type II, Cfr10I/Bse634I

Restrct_endonuc_II_Cfr10I

2

IPR012416

12,416

CALMODULIN-BINDING PROTEIN60

CBP60

Family

7,250

false

CALMODULIN-BINDING PROTEIN60 (CBP60) family from plants have been known to be involved in both biotic and abiotic stress responses [ ]. Some members (for example, ), are known to be involved in the induction of plant defence responses [ ]. In Arabidopsis, CBP60s have eight members, including CBP60g and SARD1, which enc...

[ "GO:0005516" ]

[ "calmodulin binding" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR31713" ]

[ "" ]

[ 7250 ]

1

[]

0

[]

0

[ "PUB00016592", "PUB00074918", "PUB00074919", "PUB00074920" ]

[ "12777041", "24134885", "20921422", "22466450" ]

[ "Differential expression of genes encoding calmodulin-binding proteins in response to bacterial pathogens and inducers of defense responses.", "The CALMODULIN-BINDING PROTEIN60 family includes both negative and positive regulators of plant immunity.", "Control of salicylic acid synthesis and systemic acquired r...

[ 2003, 2013, 2010, 2012 ]

4

[]

0

null

[ "Viridiplantae" ]

[ 7250 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 40, 77, 86 ]

3

true

Family

CALMODULIN-BINDING PROTEIN60

CBP60

9

IPR012417

12,417

Calmodulin-binding domain, plant

CaM-bd_dom_pln

Domain

3,502

false

This domain is found repeated in a number of plant calmodulin-binding proteins (such as , and ). It is thought to represent a calmodulin-binding domain [ , ]. Binding of the proteins to calmodulin depends on the presence of calcium ions [ , ]. Proteins containing this domain are thought to be involved in various proces...

[ "GO:0005516" ]

[ "calmodulin binding" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF07839", "SM01054" ]

[ "CaM_binding", "CaM_binding" ]

[ 3500, 3006 ]

2

[]

0

[]

0

[ "PUB00016388", "PUB00016603" ]

[ "12825696", "11684678" ]

[ "Characterization of a pathogen-induced calmodulin-binding protein: mapping of four Ca2+-dependent calmodulin-binding domains.", "Isolation and characterization of a novel calmodulin-binding protein from potato." ]

[ 2003, 2002 ]

2

[]

0

null

[ "Embryophyta" ]

[ 3502 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 27, 28, 36 ]

3

true

Domain

Calmodulin-binding domain, plant

CaM-bd_dom_pln

4

IPR012418

12,418

CAP160

Repeat

500

false

This region featured in this family is repeated in spinach cold acclimation protein CAP160 ( ) CAP160 is induced during periods of drought stress; its precise function is unknown but it has been implicated in the stabilisation of membranes, cytoskeletal elements, and ribosomes. By acting as a compatible solute, it may ...

[]

0

[ "PFAM" ]

[ "PF07918" ]

[ "CAP160" ]

[ 500 ]

1

[]

0

[]

0

[ "PUB00016445" ]

[ "9536054" ]

[ "Characterization of a gene for spinach CAP160 and expression of two spinach cold-acclimation proteins in tobacco." ]

[ 1998 ]

1

[]

0

null

[ "Magnoliopsida" ]

[ 500 ]

1

[ "Arabidopsis thaliana" ]

[ 12 ]

1

true

Repeat

CAP160

5

IPR012419

12,419

Cas1p, 10 TM acyl transferase domain

Cas1_AcylTrans_dom

Domain

5,363

false

Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence [ ]. This entry represents the multi TM domain of the Cas1p, which was unified with the 10 TM Sugar Acyltransferase superfamily [ ]. This superfami...

[]

0

[ "PFAM" ]

[ "PF07779" ]

[ "Cas1_AcylT" ]

[ 5363 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.3.1.-", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-5710", "PWY-5794"...

[ "EC:2.3.1.-", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318", "METACYC:PWY-53...

219

[]

0

[ "PUB00016435", "PUB00057249" ]

[ "11703667", "20056006" ]

[ "Cas1p is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide.", "Novel eukaryotic enzymes modifying cell-surface biopolymers." ]

[ 2001, 2010 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5363 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 19, 4, 2, 3, 2, 12, 5, 37 ]

8

true

Domain

Cas1p, 10 TM acyl transferase domain

Cas1_AcylTrans_dom

1

IPR012420

12,420

Cbp4

Family

1,459

false

In Saccharomyces cerevisiae, Cbp4 is a mitochondrial protein required for assembly of cytochrome bc1 complex [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07960", "PTHR28202" ]

[ "CBP4", "" ]

[ 1458, 1200 ]

2

[ "REACTOME" ]

[ "R-SCE-9865878" ]

[ "REACTOME:R-SCE-9865878" ]

1

[]

0

[ "PUB00016521", "PUB00016589" ]

[ "8063753", "8811190" ]

[ "Characterization of CBP4, a new gene essential for the expression of ubiquinol-cytochrome c reductase in Saccharomyces cerevisiae.", "Crosstalk between nuclear and mitochondrial genomes." ]

[ 1994, 1996 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1459 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Cbp4

2

IPR012421

12,421

WisP, C-terminal

WisP_C

Domain

3

false

This entry represents the C-terminal domain found in the Tropheryma whipplei WisP family of proteins [ ].

[]

0

[ "PFAM" ]

[ "PF07860" ]

[ "CCD" ]

[ 3 ]

1

[]

0

[]

0

[ "PUB00016368" ]

[ "12606174" ]

[ "Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." ]

[ 2003 ]

1

[]

0

null

[ "Tropheryma whipplei" ]

[ 3 ]

1

[]

0

true

Domain

WisP, C-terminal

WisP_C

9

IPR012422

12,422

Cytochrome c oxidase, subunit IV, bacterial aa3 type

Cyt_c_oxidase_su4_bac-aa3

Domain

2,210

false

Bacterial cytochrome c oxidase is found bound to the to the cell membrane, where it is involved in the generation of the transmembrane proton electrochemical gradient. It is composed of four subunits. Subunit IV consists of one transmembrane helix that does not interact directly with the other subunits, but maintains i...

[]

0

[ "PFAM" ]

[ "PF07835" ]

[ "COX4_pro_2" ]

[ 2210 ]

1

[]

0

[ "1m56", "1m57", "1qle", "5weh", "7ate", "7atn", "7au3", "7au6" ]

8

[ "PUB00016496" ]

[ "12144789" ]

[ "The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadati", "ecological metagenomes" ]

[ 2, 2196, 12 ]

3

[]

0

true

Domain

Cytochrome c oxidase, subunit IV, bacterial aa3 type

Cyt_c_oxidase_su4_bac-aa3

9

IPR012423

12,423

Chromatin modification-related protein Eaf7/MRGBP

Eaf7/MRGBP

Family

3,759

false

This entry includes fungal chromatin modification-related protein Eaf7 and its mammalian homologue, MRG/MORF4L-binding protein (MRGBP). Eaf7/MRGBP is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal ...

[ "GO:0006355", "GO:0005634", "GO:0043189" ]

[ "regulation of DNA-templated transcription", "nucleus", "H4/H2A histone acetyltransferase complex" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF07904", "PTHR13581" ]

[ "Eaf7", "" ]

[ 3504, 3540 ]

2

[ "REACTOME" ]

[ "R-HSA-3214847" ]

[ "REACTOME:R-HSA-3214847" ]

1

[ "2n1d" ]

1

[ "PUB00016517" ]

[ "15353583" ]

[ "Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3759 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 3, 1, 1, 2, 1, 2, 8, 1, 1, 7 ]

12

true

Family

Chromatin modification-related protein Eaf7/MRGBP

Eaf7/MRGBP

8

IPR012424

12,424

Conjugative transposon, TraJ, C-terminal

Conjugative_transposon_TraJ_C

Domain

3,131

false

Proteins in this entry are designated TraJ and are found in a proposed transfer region of a class of conjugative transposon found primarily in the Bacteroides lineage. They are related to conjugation system proteins in the Proteobacteria, including TrbL of Agrobacterium Ti plasmids and VirB6. This entry represents the ...

[]

0

[ "PFAM" ]

[ "PF07863" ]

[ "CtnDOT_TraJ" ]

[ 3131 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3073, 6, 52 ]

3

[]

0

true

Domain

Conjugative transposon, TraJ, C-terminal

Conjugative_transposon_TraJ_C

5

IPR012425

12,425

DmpG-like communication

DmpG_comm

Domain

6,077

false

This domain is found towards the C-terminal region of various aldolase enzymes. It consists of five α-helices, four of which form an antiparallel helical bundle that plugs the C terminus of the N-terminal TIM barrel domain [ ]. The communication domain is thought to play an important role in the heterodimerisation of t...

[ "GO:0016833", "GO:0009056" ]

[ "oxo-acid-lyase activity", "catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07836" ]

[ "DmpG_comm" ]

[ 6077 ]

1

[ "EC", "METACYC" ]

[ "4.1.3.39", "PWY-5162" ]

[ "EC:4.1.3.39", "METACYC:PWY-5162" ]

2

[ "1nvm", "4jn6", "4lrs", "4lrt", "8ih7" ]

5

[ "PUB00016385" ]

[ "12764229" ]

[ "Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Bathycoccus sp. RCC716 virus 2", "Eukaryota", "Halobacteriales", "Sym plasmid", "unclassified sequences" ]

[ 6013, 1, 9, 13, 1, 40 ]

6

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DmpG-like communication

DmpG_comm

3

IPR012426

12,426

Cell division protein SepF, archaea

SepF_arc

Family

498

false

This protein family represents the Cell division protein SepF and similar uncharacterised archaeal protein. Proteins in this family show sequence similarity to the bacterial SepF protein, which accumulates at the cell division site in an FtsZ-dependent manner and is required for proper septum formation [ ]. SepF from t...

[]

0

[ "PIRSF" ]

[ "PIRSF019313" ]

[ "UCP019313" ]

[ 498 ]

1

[]

0

[ "3zie", "3zig" ]

2

[ "PUB00043574", "PUB00099723" ]

[ "16420366", "34103513" ]

[ "SepF, a novel FtsZ-interacting protein required for a late step in cell division.", "The archaeal protein SepF is essential for cell division in Haloferax volcanii." ]

[ 2006, 2021 ]

2

[ "IPR007561" ]

[]

1

0

1

[ "Archaea", "ecological metagenomes" ]

[ 490, 8 ]

2

[]

0

true

Family

Cell division protein SepF, archaea

SepF_arc

2

IPR012427

12,427

Protein of unknown function DUF1622

DUF1622

Family

3,493

false

This is a family of highly conserved sequences, from hypothetical proteins expressed by both bacterial and archaeal species.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07784", "PTHR38468" ]

[ "DUF1622", "" ]

[ 3493, 3337 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviricetes", "metagenomes" ]

[ 116, 3328, 17, 2, 30 ]

5

[]

0

true

Family

Protein of unknown function DUF1622

DUF1622

5

IPR012429

12,429

Heparan-alpha-glucosaminide N-acetyltransferase, catalytic domain

HGSNAT_cat

Domain

14,646

false

Heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase (HGSNAT) catalyzes the transmembrane acetylation of heparan sulfate in lysosomes required for its further catabolism. Mutations of the HGSNAT gene cause the neurodegenerative disease mucopolysaccharidosis IIIC (MPS IIIC) [ ]. This entry represents the c...

[]

0

[ "PFAM" ]

[ "PF07786" ]

[ "HGSNAT_cat" ]

[ 14646 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2024096", "R-HSA-2206291", "R-HSA-6798695", "R-MMU-2024096", "R-MMU-6798695" ]

[ "REACTOME:R-HSA-2024096", "REACTOME:R-HSA-2206291", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-2024096", "REACTOME:R-MMU-6798695" ]

5

[ "8jkv", "8jl1", "8jl3", "8jl4", "8tu9", "8vkj", "8vlg", "8vli", "8vlu", "8vlv", "8vly", "8w4a" ]

12

[ "PUB00090705" ]

[ "20650889" ]

[ "Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC." ]

[ 2010 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 279, 10625, 3578, 2, 162 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 17, 5, 1, 1, 1, 17, 3, 37 ]

8

true

Domain

Heparan-alpha-glucosaminide N-acetyltransferase, catalytic domain

HGSNAT_cat

4

IPR012430

12,430

Transmembrane protein 43 family

TMEM43_fam

Family

2,758

false

This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organisers [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07787", "PTHR13416" ]

[ "TMEM43", "" ]

[ 2696, 2586 ]

2

[]

0

[]

0

[ "PUB00059300" ]

[ "18230648" ]

[ "LUMA interacts with emerin and influences its distribution at the inner nuclear membrane." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Myoviridae sp. ctLjW1", "metagenomes" ]

[ 626, 2124, 1, 7 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 5, 1, 3 ]

5

true

Family

Transmembrane protein 43 family

TMEM43_fam

1

IPR012431

12,431

PD-(D/E)XK nuclease

PDDEXK_10

Family

524

false

This family is found to carry modified motifs characteristic of PD-(D/E)XK endonuclease superfamily. These are the conserved Glu of motif I, the Asp surreounded by hydrophobics of motif II, EIKS of motif III, and the lysine of mmotif IV has migrated to an α-helix following the third core β-strand. The conserved patch o...

[]

0

[ "PFAM" ]

[ "PF07788" ]

[ "PDDEXK_10" ]

[ 524 ]

1

[]

0

[]

0

[ "PUB00016549", "PUB00044133" ]

[ "10382966", "17584917" ]

[ "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1.", "Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families with modified transitive meta profile searches." ]

[ 1999, 2007 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 232, 285, 2, 5 ]

4

[]

0

true

Family

PD-(D/E)XK nuclease

PDDEXK_10

7

IPR012432

12,432

Protein of unknown function DUF1627

DUF1627

Family

514

false

This is a group of hypothetical proteins predicted to be expressed in a number of bacterial species.

[]

0

[ "PFAM" ]

[ "PF07789" ]

[ "DUF1627" ]

[ 514 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Plasmopara halstedii", "Viruses", "human gut metagenome" ]

[ 489, 1, 22, 2 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1627

DUF1627

7

IPR012433

12,433

Immunity MXAN_0049 protein

Imm11

Domain

3,421

false

This entry, previously known as DUF1629, represents a domain found in a group of bacterial proteins, including MXAN_0049 from Myxococcus xanthus ( ), which adopts an α-β structure ( ). This domain covers the whole length of the protein in most members and is found associated with ( ) in others. Some members were identi...

[]

0

[ "PFAM" ]

[ "PF07791" ]

[ "Imm11" ]

[ 3421 ]

1

[]

0

[ "6a4c" ]

1

[ "PUB00066726" ]

[ "22731697" ]

[ "Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Knufia peltigerae", "Microviridae sp. ctoGr7", "ecological metagenomes" ]

[ 3399, 1, 2, 19 ]

4

[]

0

true

Domain

Immunity MXAN_0049 protein

Imm11

6

IPR012434

12,434

Domain of unknown function DUF1631

DUF1631

Domain

3,699

false

The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. This entry represents the N-terminal domain.

[]

0

[ "PFAM" ]

[ "PF07793" ]

[ "DUF1631" ]

[ 3699 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3634, 9, 56 ]

3

[]

0

true

Domain

Domain of unknown function DUF1631

DUF1631

4

IPR012435

12,435

TMEM144

Family

3,023

false

Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the similarity between the two halves is no longer detectable by sequence.

[]

0

[ "PFAM" ]

[ "PF07857" ]

[ "TMEM144" ]

[ 3023 ]

1

[]

0

[]

0

[]

0

[ "IPR010651" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Marseillevirus LCMAC202", "marine sediment metagenome" ]

[ 12, 3009, 1, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 4, 9, 2, 3 ]

5

true

Family

TMEM144

9

IPR012436

12,436

Protein of unknown function DUF1633

DUF1633

Family

518

false

This family contains sequences derived from a group of hypothetical proteins expressed by Arabidopsis thaliana (Mouse-ear cress). These sequences are highly similar and the region concerned is about 100 residues long.

[]

0

[ "PFAM" ]

[ "PF07794" ]

[ "DUF1633" ]

[ 518 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Brassicaceae" ]

[ 518 ]

1

[ "Arabidopsis thaliana" ]

[ 14 ]

1

true

Family

Protein of unknown function DUF1633

DUF1633

3

IPR012438

12,438

Protein of unknown function DUF1639

DUF1639

Family

5,621

false

This approximately 50-residue region is found in a number of sequences derived from hypothetical plant proteins. This region features a highly basic 5 amino-acid stretch towards its centre.

[]

0

[ "PFAM" ]

[ "PF07797" ]

[ "DUF1639" ]

[ 5621 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 5621 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 45, 31, 107 ]

3

true

Family

Protein of unknown function DUF1639

DUF1639

4

IPR012440

12,440

Helical membrane plugin domain

HMP_dom

Domain

2,895

false

This entry, previously known as DUF1641, represents the helical membrane plugin (HMP) domain found in Formate dehydrogenase essential subunit FdhD and in uncharacterised prokaryotic proteins, including the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis ( , [ ]). It is involved in the construction of oxidoreductase...

[]

0

[ "PFAM" ]

[ "PF07849" ]

[ "DUF1641" ]

[ 2895 ]

1

[]

0

[ "7uus", "8rqz", "8rr0", "9gzq" ]

4

[ "PUB00161758", "PUB00161759", "PUB00163303" ]

[ "36890228", "40855134", "34748728" ]

[ "Structural basis for bacterial energy extraction from atmospheric hydrogen.", "A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases.", "Identification and characterization of a noncanonical menaquinone-linked formate dehydrogenase." ]

[ 2023, 2025, 2022 ]

3

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 615, 2271, 9 ]

3

[]

0

true

Domain

Helical membrane plugin domain

HMP_dom

1

IPR012441

12,441

Protein of unknown function DUF1643

DUF1643

Family

3,078

false

This entry includes Bacteriophage D3, Orf41.6. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. The members of this family are all sequences found within hypothetical proteins expressed by various bacteria, archaea and phage. The region concerned is approximatel...

[]

0

[ "PFAM" ]

[ "PF07799" ]

[ "DUF1643" ]

[ 3078 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR016992" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "metagenomes" ]

[ 2871, 9, 34, 59, 105 ]

5

[]

0

true

Family

Protein of unknown function DUF1643

DUF1643

8

IPR012442

12,442

Protein of unknown function DUF1645, plant

DUF1645_plant

Family

5,557

false

These sequences are derived from a number of hypothetical plant proteins. The region in question is approximately 270 amino acids long. Some members of this family are annotated as yeast pheromone receptor proteins AR781 but no literature was found to support this.

[]

0

[ "PFAM" ]

[ "PF07816" ]

[ "DUF1645" ]

[ 5557 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 5557 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 33, 36, 59 ]

3

true

Family

Protein of unknown function DUF1645, plant

DUF1645_plant

4

IPR012443

12,443

Protein of unknown function DUF1646

DUF1646

Family

497

false

Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaeon Methanosarcina mazei (Methanosarcina frisia) ( , and ).

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07854", "PIRSF019205" ]

[ "DUF1646", "DUF1646" ]

[ 497, 439 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 153, 336, 8 ]

3

[]

0

true

Family

Protein of unknown function DUF1646

DUF1646

8

IPR012444

12,444

Protein of unknown function DUF1647

DUF1647

Family

1,371

false

This entry consists of hypothetical proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF07801" ]

[ "DUF1647" ]

[ 1371 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "metagenomes" ]

[ 1346, 18, 7 ]

3

[ "Caenorhabditis elegans" ]

[ 17 ]

1

true

Family

Protein of unknown function DUF1647

DUF1647

3

IPR012445

12,445

Autophagy-related protein 101

ATG101

Family

4,181

false

Atg101 is a critical autophagy factor that functions together with ULK, Atg13 and FIP200 [ , ]. In fission yeasts, it has a role in meiosis and sporulation [ ].

[ "GO:0006914" ]

[ "autophagy" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07855", "PTHR13292" ]

[ "ATG101", "" ]

[ 4180, 4057 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1632852", "R-DRE-1632852", "R-HSA-1632852", "R-MMU-1632852", "R-RNO-1632852", "R-SPO-1632852" ]

[ "REACTOME:R-BTA-1632852", "REACTOME:R-DRE-1632852", "REACTOME:R-HSA-1632852", "REACTOME:R-MMU-1632852", "REACTOME:R-RNO-1632852", "REACTOME:R-SPO-1632852" ]

6

[ "4wzg", "4yk8", "5c50", "5xuy", "5xv1", "5xv3", "5xv4", "5xv6", "8do8" ]

9

[ "PUB00044889", "PUB00059287", "PUB00078911" ]

[ "16303567", "19597335", "19287211" ]

[ "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.", "Atg101, a novel mammalian autophagy protein interacting with Atg13.", "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy." ]

[ 2005, 2009, 2009 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4181 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 7, 3, 2, 1, 4, 3, 1, 8, 5, 1, 7 ]

11

true

Family

Autophagy-related protein 101

ATG101

4

IPR012447

12,447

Protein of unknown function DUF1651

DUF1651

Family

139

false

This entry represents Molecular chaperone Tir from Prochlorococcus marinus and other uncharacterised proteins from bacteria.

[]

0

[ "PFAM" ]

[ "PF07864" ]

[ "DUF1651" ]

[ 139 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Synechococcales", "marine metagenome" ]

[ 137, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF1651

DUF1651

3

IPR012449

12,449

Bacteriophage F116, Orf28

Phage_F116_Orf28

Family

1,396

false

This entry is represented by Bacteriophage F116 (Pseudomonas phage F116), Orf28. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of proteins from the Pseudomonadaceae.

[]

0

[ "PFAM" ]

[ "PF07867" ]

[ "DUF1654" ]

[ 1396 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes", "Gammaproteobacteria", "metagenomes" ]

[ 9, 1384, 3 ]

3

[]

0

true

Family

Bacteriophage F116, Orf28

Phage_F116_Orf28

6

IPR012450

12,450

Bacteriophage bIL310, Orf15

Phage_bIL310_Orf15

Family

96

false

This entry is represented by Bacteriophage bIL310, Orf15. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. The proteins in this family have unknown function and are found in some Lactococcus lactis prophages [ ].

[]

0

[ "PFAM" ]

[ "PF07868" ]

[ "DUF1655" ]

[ 96 ]

1

[]

0

[]

0

[ "PUB00016516" ]

[ "11160885" ]

[ "Analysis of six prophages in Lactococcus lactis IL1403: different genetic structure of temperate and virulent phage populations." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 95, 1 ]

2

[]

0

true

Family

Bacteriophage bIL310, Orf15

Phage_bIL310_Orf15

2

IPR012451

12,451

Protein of unknown function DUF1656

DUF1656

Family

6,715

false

The proteins in this entry have no known function and belong to the AaeX family.

[]

0

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01546", "NF008615", "PF07869" ]

[ "AaeX", "PRK11594.1", "DUF1656" ]

[ 854, 864, 6715 ]

3

[]

0

[]

0

[ "PUB00054183" ]

[ "15489430" ]

[ "Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve?" ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Knufia peltigerae", "unclassified sequences" ]

[ 6696, 2, 17 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF1656

DUF1656

6

IPR012452

12,452

Protein of unknown function DUF1657

DUF1657

Family

3,407

false

This domain appears to be restricted to the Bacillales.

[]

0

[ "PFAM" ]

[ "PF07870" ]

[ "DUF1657" ]

[ 3407 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 3397, 10 ]

2

[]

0

true

Family

Protein of unknown function DUF1657

DUF1657

8

IPR012454

12,454

Domain of unknown function DUF1659

DUF1659

Domain

3,302

false

This entry represents a domain of unknown function in hypothetical uncharacerised bacterial proteins mainly terrabaceria. This domain contains a β-sheet connected to a small α-helix.

[]

0

[ "PFAM" ]

[ "PF07872" ]

[ "DUF1659" ]

[ 3302 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Cylicocyclus nassatus", "unclassified sequences" ]

[ 3259, 1, 42 ]

3

[]

0

true

Domain

Domain of unknown function DUF1659

DUF1659

4

IPR012455

12,455

Protein of unknown function DUF1660

DUF1660

Family

629

false

This protein family of unknown function is found in several bacteriophages and suspected prophages.

[]

0

[ "PFAM" ]

[ "PF07874" ]

[ "DUF1660" ]

[ 629 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 609, 15, 5 ]

3

[]

0

true

Family

Protein of unknown function DUF1660

DUF1660

9

IPR012456

12,456

Protein of unknown function DUF1661

DUF1661

Family

140

false

The proteins in this entry have not been characterised.

[]

0

[ "PFAM" ]

[ "PF07877" ]

[ "DUF1661" ]

[ 140 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Porphyromonas" ]

[ 140 ]

1

[]

0

true

Family

Protein of unknown function DUF1661

DUF1661

5

IPR012457

12,457

Domain of unknown function DUF1663

DUF1663

Domain

33

false

The members of this family are hypothetical proteins expressed by Trypanosoma cruzi, a eukaryotic parasite that causes Chagas disease in humans. This region is found as multiple copies per protein.

[]

0

[ "PFAM" ]

[ "PF07909" ]

[ "DUF1663" ]

[ 33 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Trypanosoma" ]

[ 33 ]

1

[]

0

true

Domain

Domain of unknown function DUF1663

DUF1663

4

IPR012458

12,458

Domain of unknown function DUF1664

DUF1664

Domain

2,541

false

The region featured in this entry is approximately 100 amino acids long. It is found in hypothetical plant proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF07889" ]

[ "DUF1664" ]

[ 2541 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 8, 2533 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 26, 15, 38 ]

3

true

Domain

Domain of unknown function DUF1664

DUF1664

6

IPR012459

12,459

Ribosomal RNA-processing protein 15

Rrp15

Family

4,371

false

Rrp15 is a constituent of pre-60S ribosomal particles. It is required for large subunit rRNA maturation, in particular processing of the 27S pre-rRNA at the A3 and B1 sites to yield 5.8S and 25S rRNA [ ].

[ "GO:0006364" ]

[ "rRNA processing" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07890", "PTHR13245" ]

[ "Rrp15p", "" ]

[ 4294, 4171 ]

2

[]

0

[ "6c0f", "8fkp", "8fkq", "8fkr", "8fks", "8i9r", "8i9t", "8v83", "8v84" ]

9

[ "PUB00020276" ]

[ "15769876" ]

[ "Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 4370, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 3, 1, 1, 3, 2, 1, 1, 5 ]

12

true

Family

Ribosomal RNA-processing protein 15

Rrp15

5

IPR012460

12,460

Protein of unknown function DUF1667

DUF1667

Family

2,126

false

Hypothetical archaeal and bacterial proteins make up this family. A few proteins are annotated as being potential metal-binding proteins, and in fact the members of this family have four highly conserved cysteine residues, but no further literature evidence was found in this regard.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07892", "PTHR39450" ]

[ "DUF1667", "" ]

[ 2125, 2045 ]

2

[]

0

[ "2jov" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 79, 1950, 39, 58 ]

4

[]

0

true

Family

Protein of unknown function DUF1667

DUF1667

2

IPR012461

12,461

Scaffolding anchor of CK1 domain

SACK1

Domain

7,627

false

This entry represents the scaffolding anchor of CK1 domain (SACK1 domain) found at the N-terminal of FAM83 proteins, which includes FAM83A-H. This domain was formerly known as DUF1669 and it has been identified as a CK1 binding domain, which allows the correct subcellular localisation of both FAM83 proteins and the CK1...

[]

0

[ "PFAM" ]

[ "PF07894" ]

[ "SACK1" ]

[ 7627 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-177929", "R-HSA-177929", "R-HSA-9696264", "R-HSA-9696270", "R-HSA-9696273", "R-MMU-177929", "R-MMU-9696264", "R-MMU-9696270", "R-MMU-9696273", "R-XTR-177929" ]

[ "REACTOME:R-DRE-177929", "REACTOME:R-HSA-177929", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696270", "REACTOME:R-HSA-9696273", "REACTOME:R-MMU-177929", "REACTOME:R-MMU-9696264", "REACTOME:R-MMU-9696270", "REACTOME:R-MMU-9696273", "REACTOME:R-XTR-177929" ]

10

[ "4urj", "5lzk", "5qhi", "5qhj", "5qhk", "5qhl", "5qhm", "5qhn", "5qho", "5qhp", "5qhq", "5qhr", "5qhs" ]

13

[ "PUB00084963", "PUB00092186", "PUB00124155", "PUB00155371", "PUB00155372", "PUB00155373", "PUB00155374", "PUB00155375" ]

[ "27221039", "18252228", "18485706", "22886303", "23676467", "23912460", "29789297", "24554596" ]

[ "FAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistance.", "FAM83H mutations in families with autosomal-dominant hypocalcified amelogenesis imperfecta.", "The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle.", "FAM83A conf...

[ 2016, 2008, 2008, 2012, 2013, 2014, 2018, 2014 ]

8

[]

[ "IPR041996" ]

0

1

0

[ "Bacteroidota", "Bilateria" ]

[ 2, 7625 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 22, 14, 13, 16 ]

4

true

Domain

Scaffolding anchor of CK1 domain

SACK1

4

IPR012462

12,462

UFSP1/2/DUB, catalytic domain

UFSP1/2_DUB_cat

Domain

7,403

false

This is the C-terminal catalytic domain of UFSP), Zinc finger-containing ubiquitin peptidase 1 (DUB) and similar eukaryotic proteins. It shows seven α-helices and seven β-strands, resembling the papain-like structure [ ]. UFM1-specific isopeptidase 1 and 2 (UFSP1 and UFSP2) are cysteine peptidases essential for both th...

[]

0

[ "PFAM" ]

[ "PF07910" ]

[ "Peptidase_C78" ]

[ 7403 ]

1

[ "EC" ]

[ "3.4.22.-" ]

[ "EC:3.4.22.-" ]

1

[ "2z84", "3oqc", "5ejj", "5xda", "6ei1", "6fge", "7oiy", "7oje" ]

8

[ "PUB00034739", "PUB00034740", "PUB00151643", "PUB00152786", "PUB00152787", "PUB00152788", "PUB00152789", "PUB00154319", "PUB00154320" ]

[ "17182609", "15071506", "21228277", "29476094", "29563501", "29576527", "29576528", "27240952", "29251776" ]

[ "Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2.", "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier.", "Structure of ubiquitin-fold modifier 1-specific protease UfSP2.", "A family of unconventional deubiquitinases with modular chain specificity determinan...

[ 2007, 2004, 2011, 2018, 2018, 2018, 2018, 2016, 2018 ]

9

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 7401, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 13, 1, 6, 3, 11, 6, 1, 5, 8, 1, 24 ]

11

true

Domain

UFSP1/2/DUB, catalytic domain

UFSP1/2_DUB_cat

2

IPR012463

12,463

Ethylene-responsive binding factor-associated repression

Ninja_motif

Domain

1,712

false

The EAR motif is the ethylene-responsive element binding factor-associated amphiphilic repression motif. This motif binds to the Groucho/Tup1-type co-repressor TOPLESS (TPL) and TPL-related proteins. The motif is frequently to be find at the N terminus of NINJA, or Novel INteractor of JAZ, proteins [ ]. The EAR motif, ...

[]

0

[ "PFAM" ]

[ "PF07897" ]

[ "EAR" ]

[ 1712 ]

1

[]

0

[]

0

[ "PUB00066523", "PUB00075457" ]

[ "20360743", "20935498" ]

[ "NINJA connects the co-repressor TOPLESS to jasmonate signalling.", "EAR motif-mediated transcriptional repression in plants: an underlying mechanism for epigenetic regulation of gene expression." ]

[ 2010, 2011 ]

2

[]

0

null

[ "Mesangiospermae" ]

[ 1712 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 21, 9, 17 ]

3

true

Domain

Ethylene-responsive binding factor-associated repression

Ninja_motif

6

IPR012464

12,464

Protein of unknown function DUF1676

DUF1676

Family

6,596

false

This family contains proteins of unknown function expressed by Drosophila melanogaster and Anopheles gambiae.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07898", "PTHR21879" ]

[ "DUF1676", "" ]

[ 6477, 5995 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteroidota", "Eukaryota" ]

[ 2, 6594 ]

2

[ "Drosophila melanogaster", "Zea mays" ]

[ 38, 1 ]

2

true

Family

Protein of unknown function DUF1676

DUF1676

2

IPR012465

12,465

Protein of unknown function DUF1678

DUF1678

Family

27

false

This family is composed of uncharacterised proteins expressed by Methanopyrus kandleri, a hyperthermophilic archaeon.

[]

0

[ "PFAM" ]

[ "PF07913" ]

[ "DUF1678" ]

[ 27 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bythopirellula polymerisocia", "Methanopyrus kandleri" ]

[ 1, 26 ]

2

[]

0

true

Family

Protein of unknown function DUF1678

DUF1678

6

IPR012466

12,466

NECAP, PHear domain

NECAP_PHear

Domain

6,241

false

This PH-like domain can be found in the N-terminal region of NECAPs (also known as adaptin ear-binding coat-associated proteins). NECAPs are alpha-ear-binding proteins that enrich on clathrin-coated vesicles (CCVs). NECAP-1 is expressed in brain and non-neuronal tissues and cells while NECAP-2 is ubiquitously expressed...

[ "GO:0006897", "GO:0016020" ]

[ "endocytosis", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "CDD" ]

[ "PF07933", "cd13228" ]

[ "DUF1681", "PHear_NECAP" ]

[ 6237, 5583 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-432722", "R-BTA-8856825", "R-BTA-8856828", "R-DME-432722", "R-DME-8856825", "R-DME-8856828", "R-HSA-432722", "R-HSA-8856825", "R-HSA-8856828", "R-MMU-432722", "R-MMU-8856825", "R-MMU-8856828", "R-RNO-432722", "R-RNO-8856825", "R-RNO-8856828" ]

[ "REACTOME:R-BTA-432722", "REACTOME:R-BTA-8856825", "REACTOME:R-BTA-8856828", "REACTOME:R-DME-432722", "REACTOME:R-DME-8856825", "REACTOME:R-DME-8856828", "REACTOME:R-HSA-432722", "REACTOME:R-HSA-8856825", "REACTOME:R-HSA-8856828", "REACTOME:R-MMU-432722", "REACTOME:R-MMU-8856825", "REACTOME:R-...

15

[ "1tqz", "6owo", "6oxl", "6rh5", "6rh6" ]

5

[ "PUB00014130", "PUB00080400", "PUB00080401", "PUB00080402", "PUB00080403", "PUB00080404" ]

[ "14594214", "17762867", "22728242", "17233582", "15766521", "15493994" ]

[ "Membrane targeting by pleckstrin homology domains.", "The NECAP PHear domain increases clathrin accessory protein binding potential.", "Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.", "Pleckstrin homology (PH) domains and phosphoinositides.", "Pleckstri...

[ 2004, 2007, 2012, 2007, 2005, 2004 ]

6

[]

0

null

[ "Eukaryota" ]

[ 6241 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 2, 4, 2, 15, 6, 1, 7, 12, 6 ]

10

true

Domain

NECAP, PHear domain

NECAP_PHear

2

IPR012467

12,467

Protein of unknown function DUF1684

DUF1684

Family

6,830

false

The sequences featured in this family are found in hypothetical archaeal and bacterial proteins of unknown function. The region in question is approximately 200 amino acids long. It adopts a β-barrel fold ( ) that has some similarity to Core-binding factor subunit beta ( ).

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07920", "PTHR41913" ]

[ "DUF1684", "" ]

[ 6819, 6770 ]

2

[]

0

[ "2lnu", "2lok", "4dlh", "4fj4" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 465, 6287, 8, 70 ]

4

[]

0

true

Family

Protein of unknown function DUF1684

DUF1684

1

IPR012468

12,468

Protein of unknown function DUF1686

DUF1686

Family

61

false

The members of this family are all hypothetical proteins of unknown function expressed by the eukaryotic parasite Encephalitozoon cuniculi GB-M1. The region in question is approximately 250 amino acids long.

[]

0

[ "PFAM" ]

[ "PF07937" ]

[ "DUF1686" ]

[ 61 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Encephalitozoon" ]

[ 61 ]

1

[]

0

true

Family

Protein of unknown function DUF1686

DUF1686

2