LiteFold/InterPro · Datasets at Hugging Face

IPR012469

12,469

Protein of unknown function DUF1688

DUF1688

Family

3,311

false

This family of uncharacterised fungal and bacterial proteins includes URC4 from the yeast Saccharomyces kluyveri. URC4 is a protein involved in uracil catabolism, but its exact function is not known [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07958", "PTHR31687" ]

[ "DUF1688", "" ]

[ 3311, 3286 ]

2

[]

0

[]

0

[ "PUB00080233", "PUB00086970" ]

[ "18550080", "20544532" ]

[ "A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes.", "Ribosylurea accumulates in yeast urc4 mutants." ]

[ 2008, 2010 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 897, 2404, 10 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Protein of unknown function DUF1688

DUF1688

6

IPR012470

12,470

PDR1 up-regulated protein 1-like

Pup1-like

Family

192

false

This entry represents a group of fungal proteins, including Pup1 from Candida glabrata. Pup1 is a mitochondrial protein that contributes to the enhanced virulence of C.glabrata strains that acquired azole resistance [ ].

[]

0

[ "PFAM" ]

[ "PF07954" ]

[ "DUF1689" ]

[ 192 ]

1

[]

0

[]

0

[ "PUB00090179" ]

[ "23460523" ]

[ "Gain-of-function mutations in PDR1, a regulator of antifungal drug resistance in Candida glabrata, control adherence to host cells." ]

[ 2013 ]

1

[]

0

null

[ "Dikarya" ]

[ 192 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

PDR1 up-regulated protein 1-like

Pup1-like

3

IPR012471

12,471

Protein of unknown function DUF1690

DUF1690

Family

1,734

false

Family of uncharacterised fungal proteins.

[]

0

[ "PFAM" ]

[ "PF07956" ]

[ "DUF1690" ]

[ 1734 ]

1

[]

0

[ "7pv0" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 1734 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Protein of unknown function DUF1690

DUF1690

5

IPR012472

12,472

Mitochondrial adapter protein MCP1, transmembrane domain

MCP1_TM

Domain

1,372

false

This entry represents the transmembrane domains found in Mitochondrial adapter protein MCP1 from yeast, a mitochondrial protein involved in mitochondrial lipid homeostasis [ ]. MCP1 recruits the lipid transfer protein Vps13 to mitochondria promoting vacuole-mitochondria contacts [ , , ].

[]

0

[ "PFAM" ]

[ "PF07950" ]

[ "MCP1_TM" ]

[ 1372 ]

1

[]

0

[]

0

[ "PUB00090363", "PUB00100501", "PUB00100725", "PUB00100726" ]

[ "23781023", "30018089", "28864540", "34830155" ]

[ "Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis.", "Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites.", "Vps13-Mcp1 interact at vacuole-mitochondria interfaces and bypass ER-mitochondria contact sites.", "The GTPase Arf1 Is a Determinant of Yeast V...

[ 2013, 2018, 2017, 2021 ]

4

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 2, 1370 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

Mitochondrial adapter protein MCP1, transmembrane domain

MCP1_TM

8

IPR012473

12,473

Fibritin C-terminal

Fibritin_C

Domain

315

false

This domain is found at the C terminus of the Bacteriophage T4 protein fibritin ( ). Fibritin is responsible for attachment of long tail fibres to virus particle, and forms the "whiskers" or fibres on the neck of the virion. This domain contains an N-terminal coiled-coil portion and the C-terminal globular "foldon" reg...

[]

0

[ "PFAM", "PRINTS" ]

[ "PF07921", "PR01880" ]

[ "Fibritin_C", "FIBRITIN" ]

[ 314, 217 ]

2

[]

0

[ "1aa0", "1avy", "1nay", "1ox3", "1rfo", "1u0p", "1v1i", "2bsg", "2ibl", "2kbl", "2lp7", "2m7w", "2ww6", "3a1m", "3j2o", "4ncu", "4ncv", "4ncw", "5jq3", "5jq7", "5jqb", "5x59", "5x5c", "5x5f", "5ykc", "5yt8", "5yt9", "5z88", "6a0z", "6cnv", "6cxc", "6f5u"...

238

[ "PUB00016564" ]

[ "15033360" ]

[ "Very fast folding and association of a trimerization domain from bacteriophage T4 fibritin." ]

[ 2004 ]

1

[]

0

null

[ "Orchesella dallaii", "Pseudomonadati", "Viruses" ]

[ 1, 5, 309 ]

3

[]

0

true

Domain

Fibritin C-terminal

Fibritin_C

2

IPR012474

12,474

Frigida-like

Frigida

Family

6,224

false

This family is composed of plant proteins that are similar to FRIGIDA protein expressed by Arabidopsis thaliana (Mouse-ear cress) ( ). This protein is probably nuclear and is required for the regulation of flowering time in the late-flowering phenotype. It is known to increase RNA levels of flowering locus C. Allelic v...

[]

0

[ "PFAM" ]

[ "PF07899" ]

[ "Frigida" ]

[ 6224 ]

1

[]

0

[ "5ch6" ]

1

[ "PUB00016513" ]

[ "11030654" ]

[ "Molecular analysis of FRIGIDA, a major determinant of natural variation in Arabidopsis flowering time." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 6224 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 109, 47, 73 ]

3

true

Family

Frigida-like

Frigida

3

IPR012475

12,475

Fucose-specific lectin

Fungal_lectin

Family

1,111

false

Lectins are involved in many recognition events at the molecular or cellular level. These fungal lectins, such as Aleuria aurantialectin (AAL, ), specifically recognise fucosylated glycans. AAL is a dimeric protein, with each monomer being organised into a six-bladed β-propeller fold and a small antiparallel two-strand...

[]

0

[ "PFAM" ]

[ "PF07938" ]

[ "Fungal_lectin" ]

[ 1111 ]

1

[]

0

[ "1iub", "1iuc", "1ofz", "2bs5", "2bs6", "2bt9", "3zi8", "3zw0", "3zw1", "3zw2", "3zwe", "3zzv", "4agi", "4agt", "4ah4", "4aha", "4c1y", "4csd", "4d4u", "4d52", "4i6s", "4uou", "5ajb", "5ajc", "5eo7", "5eo8", "5h47", "5mxc", "5o7u", "5o7v", "5o7w", "6f37"...

101

[ "PUB00016599" ]

[ "12732625" ]

[ "Crystal structure of fungal lectin: six-bladed beta-propeller fold and novel fucose recognition mode for Aleuria aurantia lectin." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 63, 1048 ]

2

[]

0

true

Family

Fucose-specific lectin

Fungal_lectin

4

IPR012476

12,476

mRNA export factor GLE1-like

GLE1

Family

4,912

false

This family includes human protein GLE1 ( ) and its homologues. This protein is localised at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm [ , ]. In Arabidopsis, it is required for seed viability [ ].

[ "GO:0016973", "GO:0005643" ]

[ "poly(A)+ mRNA export from nucleus", "nuclear pore" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF07817", "PTHR12960" ]

[ "GLE1", "" ]

[ 4699, 4733 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-159236", "R-DME-159236", "R-HSA-159236", "R-MMU-159236", "R-RNO-159236", "R-SCE-159236", "R-SPO-159236" ]

[ "REACTOME:R-BTA-159236", "REACTOME:R-DME-159236", "REACTOME:R-HSA-159236", "REACTOME:R-MMU-159236", "REACTOME:R-RNO-159236", "REACTOME:R-SCE-159236", "REACTOME:R-SPO-159236" ]

7

[ "3peu", "3pev", "3rrm", "3rrn", "6b4e", "6b4f", "6b4g", "6b4h", "6b4i", "6b4j", "7tbl" ]

11

[ "PUB00016475", "PUB00096856", "PUB00099579" ]

[ "9618489", "22898497", "16000379" ]

[ "The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export.", "LONO1 encoding a nucleoporin is required for embryogenesis and seed viability in Arabidopsis.", "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export ...

[ 1998, 2012, 2005 ]

3

[]

0

null

[ "Eukaryota", "Siphoviridae sp. ctgN495" ]

[ 4911, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 9, 3, 1, 10, 1, 1, 5, 6, 1, 1, 33 ]

11

true

Family

mRNA export factor GLE1-like

GLE1

1

IPR012478

12,478

GSG1-like

GSG-1

Family

3,387

false

This entry represents GSG1 (germ cell-specific gene 1 protein), a protein specifically expressed in testicular germ cells [ ]. It has been shown to target testis-specific poly(A) polymerase to the endoplasmic reticulum through protein-protein interactions [ ]. Overexpression of the human homologue may be involved in tu...

[]

0

[ "PFAM" ]

[ "PF07803" ]

[ "GSG-1" ]

[ 3387 ]

1

[]

0

[ "5vhw", "5vhx", "5vhy", "5vhz", "5wek", "5wel", "5wem", "5wen", "7ryz", "7rz9", "7rza" ]

11

[ "PUB00016582", "PUB00076674" ]

[ "9337410", "18325338" ]

[ "Mapping of six germ-cell-specific genes to mouse chromosomes.", "Germ cell-specific gene 1 targets testis-specific poly(A) polymerase to the endoplasmic reticulum through protein-protein interactions." ]

[ 1997, 2008 ]

2

[]

0

null

[ "Vertebrata" ]

[ 3387 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 11, 4, 7 ]

4

true

Family

GSG1-like

GSG-1

7

IPR012479

12,479

SAP30-binding protein

SAP30BP

Family

4,699

false

This entry represents the SAP30-binding protein that may act as a transcriptional co-repressor of a gene related to cell survival and induce cell death [ ]. Proteins in this entry also include the meiotically up-regulated gene 151 protein from fission yeast [ ].

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07818", "PTHR13464" ]

[ "HCNGP", "" ]

[ 4608, 4487 ]

2

[ "REACTOME" ]

[ "R-HSA-427413" ]

[ "REACTOME:R-HSA-427413" ]

1

[]

0

[ "PUB00044889", "PUB00068039" ]

[ "16303567", "15496587" ]

[ "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.", "HTRP--an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors." ]

[ 2005, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4699 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 1, 1, 1, 10, 1, 1, 6, 4, 1, 15 ]

11

true

Family

SAP30-binding protein

SAP30BP

1

IPR012480

12,480

Heparinase II/III-like, C-terminal

Hepar_II_III_C

Domain

13,982

false

This is the C-terminal domain of heparin and heparin-sulfate lyase (HepB, also known as heparinase II), heparin-sulfate lyase (HepC, also known as heparinase III) and distantly related sequences. The structures of heparinase II and III have been solved [ , ]. HepB cleaves both heparin and heparan sulfate glycosaminogly...

[ "GO:0016829" ]

[ "lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07940" ]

[ "Hepar_II_III_C" ]

[ 13982 ]

1

[]

0

[ "2fuq", "2fut", "3a0o", "3afl", "3e7j", "3e80", "4fnv", "4mmh", "4mmi", "4nei", "4ojz", "4ok2", "4ok4", "5jmd", "5jmf", "6jp4", "6jph", "6jpn", "6lja", "6ljl", "7bjt", "7bm6", "8bdd", "8khv", "8khw", "8r6z", "8r70", "8r71", "8r72", "8r73", "8r75", "9irq"...

33

[ "PUB00016410", "PUB00040822", "PUB00075988", "PUB00154826", "PUB00154827" ]

[ "8702264", "16565082", "23011846", "10747789", "27028265" ]

[ "Isolation and expression in Escherichia coli of hepB and hepC, genes coding for the glycosaminoglycan-degrading enzymes heparinase II and heparinase III, respectively, from Flavobacterium heparinum.", "Crystal structure of heparinase II from Pedobacter heparinus and its complex with a disaccharide product.", "...

[ 1996, 2006, 2012, 2000, 2016 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 71, 13256, 502, 153 ]

4

[]

0

true

Domain

Heparinase II/III-like, C-terminal

Hepar_II_III_C

6

IPR012481

12,481

Kanamycin nucleotidyltransferase, C-terminal

KNTase_C

Domain

331

false

Kanamycin nucleotidyltransferase (KNTase) is involved in conferring resistance to aminoglycoside antibiotics and catalyses the transfer of a nucleoside monophosphate group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit being composed of two domains. The C-terminal domain contains five α helice...

[ "GO:0016779", "GO:0046677" ]

[ "nucleotidyltransferase activity", "response to antibiotic" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07827" ]

[ "KNTase_C" ]

[ 331 ]

1

[]

0

[ "1kan", "1kny", "6nlt", "6nmk", "6nml", "6nmm", "6nmn", "6p01", "6p04", "6p06", "6p08", "6un8" ]

12

[ "PUB00016504" ]

[ "7577914" ]

[ "Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "Plasmid pUB110", "bioreactor metagenome" ]

[ 329, 1, 1 ]

3

[]

0

true

Domain

Kanamycin nucleotidyltransferase, C-terminal

KNTase_C

1

IPR012483

12,483

Inner membrane mitoribosome receptor Mba1, Saccharomycetales

Mba1_Saccharomycetales

Family

71

false

This entry represents budding yeast Mba1 proteins. Mba1 is an inner membrane protein that is part of the mitochondrial protein export machinery [ , ]. It binds to the large subunit of mitochondrial ribosomes and cooperates with the C-terminal ribosome-binding domain of Oxa1, which is a central component of the insertio...

[ "GO:0043022", "GO:0005743" ]

[ "ribosome binding", "mitochondrial inner membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF022613" ]

[ "MBA1" ]

[ 71 ]

1

[]

0

[]

0

[ "PUB00016453", "PUB00016554", "PUB00042558" ]

[ "11381092", "8690083", "16601683" ]

[ "Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae.", "MBA1 encodes a mitochondrial membrane-associated protein required for biogenesis of the respiratory chain.", "Mba1, a membrane-associated ribosome receptor in mitochondria." ]

[ 2001, 1996, 2006 ]

3

[ "IPR024621" ]

[]

1

0

1

[ "saccharomyceta" ]

[ 71 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Inner membrane mitoribosome receptor Mba1, Saccharomycetales

Mba1_Saccharomycetales

2

IPR012484

12,484

Metallothionein family 7

Metalthion_7

Family

33

false

The sequence making up family 7 of the metallothionein superfamily are found repeated in metallothionein proteins expressed by two Tetrahymena species. Metallothioneins are low molecular mass, cysteine-rich metal-binding proteins that are thought to be involved in the regulation of levels of trace metals, and detoxific...

[ "GO:0046870" ]

[ "cadmium ion binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07846" ]

[ "Metallothio_Cad" ]

[ 33 ]

1

[]

0

[]

0

[ "PUB00016598" ]

[ "7813475" ]

[ "Purification and primary structure of metallothioneins induced by cadmium in the protists Tetrahymena pigmentosa and Tetrahymena pyriformis." ]

[ 1994 ]

1

[]

0

null

[ "Tetrahymena" ]

[ 33 ]

1

[]

0

true

Family

Metallothionein family 7

Metalthion_7

5

IPR012485

12,485

Centromere protein I

CENP-I

Family

2,490

false

Centromere protein I (CENP-I) is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation [ ]. It may be involved in incorporation of newly synthesized CENP-A into centromeres via it...

[ "GO:0000070", "GO:0034080", "GO:0000776" ]

[ "mitotic sister chromatid segregation", "CENP-A containing chromatin assembly", "kinetochore" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF07778" ]

[ "CENP-I" ]

[ 2490 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-GGA-141444", "R-GGA-2467813", "R-GGA-2500257", "R-GGA-5663220", "R-GGA-606279", "R-GGA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-606279", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", ...

[ "REACTOME:R-GGA-141444", "REACTOME:R-GGA-2467813", "REACTOME:R-GGA-2500257", "REACTOME:R-GGA-5663220", "REACTOME:R-GGA-606279", "REACTOME:R-GGA-9648025", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-606279", "REACTOME:R-...

27

[ "5z07", "5z08", "7pb4", "7pkn", "7qoo", "7r5s", "7r5v", "7xhn", "7xho", "7ywx", "7yyh" ]

11

[ "PUB00016423", "PUB00016539", "PUB00044860", "PUB00067769", "PUB00067770" ]

[ "9230309", "10864871", "16622420", "12640463", "11970896" ]

[ "Mis6, a fission yeast inner centromere protein, acts during G1/S and forms specialized chromatin required for equal segregation.", "Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.", "The CENP-H-I complex is required for the efficient incorporation of newly synthe...

[ 1997, 2000, 2006, 2003, 2002 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2490 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 4, 4, 1, 4, 1 ]

6

true

Family

Centromere protein I

CENP-I

5

IPR012486

12,486

Far11/STRP, N-terminal

Far11/STRP_N

Domain

5,145

false

This domain can be found in the N terminus of the yeast Far11 protein and the human STRP1/2 proteins. Budding yeast Far11 interacts with the phosphatases Pph21, Pph22, and Pph3 and may be involved in the regulation of autophagy and the DNA damage signaling [ ]. STRP1/2 (also known as FAM40A/B) are regulators of cytoske...

[]

0

[ "PFAM", "SMART" ]

[ "PF07923", "SM01292" ]

[ "N1221", "N1221" ]

[ 5135, 5057 ]

2

[]

0

[ "7k36" ]

1

[ "PUB00063300", "PUB00086409" ]

[ "21834987", "22782902" ]

[ "Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.", "The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling...

[ 2011, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5145 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 9, 2, 5, 5, 2, 5, 1, 1 ]

9

true

Domain

Far11/STRP, N-terminal

Far11/STRP_N

7

IPR012488

12,488

Nodule-specific GRP-repeat

Nod_GRP

Repeat

19

false

The region featured in this family is found repeated in a number of plant proteins, some of which are expressed specifically in nodules formed during symbiotic interactions with certain bacterial species]. Some of these proteins are also termed glycine-rich proteins (GRPs), due to the presence of a glycine-rich C-termi...

[]

0

[ "PFAM" ]

[ "PF07806" ]

[ "Nod_GRP" ]

[ 19 ]

1

[]

0

[]

0

[ "PUB00016437", "PUB00016578" ]

[ "12236598", "9037164" ]

[ "Glycine-rich proteins encoded by a nodule-specific gene family are implicated in different stages of symbiotic nodule development in Medicago spp.", "The temporal and spatial transcription pattern in root nodules of Vicia faba nodulin genes encoding glycine-rich proteins." ]

[ 2002, 1997 ]

2

[]

0

null

[ "IRL clade" ]

[ 19 ]

1

[]

0

true

Repeat

Nodule-specific GRP-repeat

Nod_GRP

7

IPR012489

12,489

Nuclease A inhibitor-like

NucleaseA_inhib-like

Family

616

false

This family represents the nuclease A inhibitor NuiA expressed by Anabaena sp (NuiA, ) and similar bacterial proteins. This protein adopts an α+β fold described as an 'open jaw', which shares some similarity to the PR-1-like fold [ ]. NuiA regulates the activity of Nuclease A (NucA). The NucA inhibition by NuiA involve...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07924", "PIRSF011544" ]

[ "NuiA", "NucleaseA_inhib-like" ]

[ 616, 59 ]

2

[]

0

[ "1j57", "1ktu", "2o3b" ]

3

[ "PUB00016584", "PUB00042100" ]

[ "12095254", "17138564" ]

[ "The nuclease A inhibitor represents a new variation of the rare PR-1 fold.", "The nuclease a-inhibitor complex is characterized by a novel metal ion bridge." ]

[ 2002, 2007 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "freshwater metagenome" ]

[ 540, 75, 1 ]

3

[]

0

true

Family

Nuclease A inhibitor-like

NucleaseA_inhib-like

3

IPR012490

12,490

PaRep2a

Family

99

false

This is a family of proteins expressed by the crenarchaeon Pyrobaculum aerophilum. The members are highly variable in length and level of conservation. The presence of numerous frameshifts and internal stop codons in multiple alignments are thought to indicate that most family members are no longer functional [ ].

[]

0

[ "PFAM" ]

[ "PF07903" ]

[ "PaRep2a" ]

[ 99 ]

1

[]

0

[]

0

[ "PUB00015213" ]

[ "11792869" ]

[ "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum." ]

[ 2002 ]

1

[]

0

null

[ "Pyrobaculum aerophilum" ]

[ 99 ]

1

[]

0

true

Family

PaRep2a

8

IPR012492

12,492

Protein RED, C-terminal

RED_C

Domain

2,473

false

This domain is found at the C terminus of Red protein ( ). This and related proteins are thought to be localised to the nucleus, and contain a RED repeat which consists of a number of RE and RD sequence elements [ ]. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its...

[]

0

[ "PFAM" ]

[ "PF07807" ]

[ "RED_C" ]

[ 2473 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

3

[ "5o9z", "6q8i", "8qo9", "8qzs" ]

4

[ "PUB00016574" ]

[ "10216252" ]

[ "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2473 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 1, 1, 1, 5, 2, 4, 11, 13 ]

9

true

Domain

Protein RED, C-terminal

RED_C

2

IPR012493

12,493

Renin receptor-like

Renin_rcpt

Family

2,396

false

The sequences featured in this family are similar to the human renin receptor ( ) which contains a putative transmembrane spanning segment [ ]. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen...

[ "GO:0038023", "GO:0016020" ]

[ "signaling receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR13351" ]

[ "" ]

[ 2396 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2022377", "R-BTA-6798695", "R-DME-2022377", "R-DME-6798695", "R-HSA-2022377", "R-HSA-6798695", "R-MMU-2022377", "R-MMU-6798695", "R-RNO-2022377", "R-RNO-6798695" ]

[ "REACTOME:R-BTA-2022377", "REACTOME:R-BTA-6798695", "REACTOME:R-DME-2022377", "REACTOME:R-DME-6798695", "REACTOME:R-HSA-2022377", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-2022377", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-2022377", "REACTOME:R-RNO-6798695" ]

10

[ "6vq6", "6vq7", "6vq8", "6vqc", "6vqg", "6vqh", "6wlw", "6wm2", "6wm3", "6wm4", "6xbw", "6xby", "7khr", "7u4t", "7u8o", "7u8p", "7u8q", "7u8r", "7unf", "7uzf", "7uzg", "7uzh", "7uzi", "8xli", "9b8o", "9bra", "9brb", "9brc", "9brd", "9brq", "9brr", "9brs"...

39

[ "PUB00016428", "PUB00093608", "PUB00095097", "PUB00159963", "PUB00159964", "PUB00159965", "PUB00159966", "PUB00159967", "PUB00159968" ]

[ "12045255", "29995586", "30374053", "26376863", "29127204", "30985297", "32276428", "20579879", "20579883" ]

[ "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.", "ATP6AP2 functions as a V-ATPase assembly factor in the endoplasmic reticulum.", "TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/?-catenin signalling.", "Conditional depl...

[ 2002, 2018, 2018, 2015, 2017, 2019, 2020, 2010, 2010 ]

9

[]

0

null

[ "Eukaryota" ]

[ 2396 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1, 22, 2, 7 ]

6

true

Family

Renin receptor-like

Renin_rcpt

4

IPR012494

12,494

Reovirus minor core protein, Mu-2

Reovirus_Mu2

Family

259

false

This family represents the Reovirus core protein Mu-2. Mu-2 is a microtubule associated protein and is thought to play a key role in the formation and structural organisation of reovirus inclusion bodies [ , ].

[ "GO:0005198", "GO:0019028" ]

[ "structural molecule activity", "viral capsid" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07781" ]

[ "Reovirus_Mu2" ]

[ 259 ]

1

[]

0

[ "5zvs", "6m99", "7elh", "7yed", "7yev", "7yez", "7yf0", "7yfe", "8fjk", "8fjl", "9cyy" ]

11

[ "PUB00016446", "PUB00016568" ]

[ "11932414", "1566600" ]

[ "Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules.", "Nucleotide sequence comparison of the M1 genome segment of reovirus type 1 Lang and type 3 Dearing." ]

[ 2002, 1992 ]

2

[]

0

null

[ "Reovirales" ]

[ 259 ]

1

[]

0

true

Family

Reovirus minor core protein, Mu-2

Reovirus_Mu2

9

IPR012495

12,495

TadE-like domain

TadE-like_dom

Domain

23,553

false

This entry represents a domain that is similar to a region of the protein product of the bacterial tadE locus ( ). In various bacterial species, the tad locus is closely linked to flp-like genes, which encode proteins required for the production of pili involved in adherence to surfaces [ ]. It is thought that the tad ...

[]

0

[ "PFAM" ]

[ "PF07811" ]

[ "TadE" ]

[ 23553 ]

1

[]

0

[]

0

[ "PUB00016542" ]

[ "11553455" ]

[ "Genes for tight adherence of Actinobacillus actinomycetemcomitans: from plaque to plague to pond scum." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Kayeltresvirus", "unclassified sequences" ]

[ 23264, 10, 3, 276 ]

4

[]

0

true

Domain

TadE-like domain

TadE-like_dom

8

IPR012496

12,496

TMC domain

TMC_dom

Domain

9,355

false

These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 ( ) and EVIN2 ( ) - this region is termed the TMC domain [ ]. Mutations in these genes are implicated in a number of human conditions, such...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07810" ]

[ "TMC" ]

[ 9355 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6798695", "R-HSA-9662360", "R-HSA-9662361", "R-MMU-6798695" ]

[ "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9662360", "REACTOME:R-HSA-9662361", "REACTOME:R-MMU-6798695" ]

4

[ "7usw", "7usx", "7usy", "8tkp" ]

4

[ "PUB00016420", "PUB00016579" ]

[ "12812529", "12906855" ]

[ "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins.", "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis." ]

[ 2003, 2003 ]

2

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 9354, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 34, 1, 47, 21, 26 ]

6

true

Domain

TMC domain

TMC_dom

4

IPR012497

12,497

Neurotoxin B-IV-like

Neurotoxin_B-IV

Family

7

false

The members of this family resemble neurotoxin B-IV ( ), which is a crustacean-selective neurotoxin produced by the marine worm Cerebratulus lacteus. This highly cationic peptide is approximately 55 residues and is arranged to form two antiparallel helices connected by a well-defined loop in a hairpin structure. The br...

[ "GO:0019871", "GO:0005576" ]

[ "sodium channel inhibitor activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07822" ]

[ "Toxin_13" ]

[ 7 ]

1

[]

0

[ "1vib" ]

1

[ "PUB00016537" ]

[ "9180379" ]

[ "Structure of neurotoxin B-IV from the marine worm Cerebratulus lacteus: a helical hairpin cross-linked by disulphide bonding." ]

[ 1997 ]

1

[]

0

null

[ "Opisthokonta", "Pseudomonadati" ]

[ 3, 4 ]

2

[]

0

true

Family

Neurotoxin B-IV-like

Neurotoxin_B-IV

9

IPR012498

12,498

Alpha-A conotoxin PIVA-like

Toxin_14

Family

4

false

Alpha-A conotoxin PIVA ( ) is the major paralytic toxin found in the venom produced by the piscivorous snail Conus purpurascens. This peptide acts by blocking the acetylcholine-binding site of the nicotinic acetylcholine receptor at the neuromuscular junction [ ]. The overall shape of the peptide is described as an "ir...

[ "GO:0030550", "GO:0005576" ]

[ "acetylcholine receptor inhibitor activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07829" ]

[ "Toxin_14" ]

[ 4 ]

1

[]

0

[ "1p1p", "1pqr" ]

2

[ "PUB00016367", "PUB00016491" ]

[ "9048550", "7673220" ]

[ "NMR structure determination of a novel conotoxin, [Pro 7,13] alpha A-conotoxin PIVA.", "A new family of Conus peptides targeted to the nicotinic acetylcholine receptor." ]

[ 1997, 1995 ]

2

[]

0

null

[ "Chelyconus" ]

[ 4 ]

1

[]

0

true

Family

Alpha-A conotoxin PIVA-like

Toxin_14

3

IPR012499

12,499

Janus-atracotoxin

Toxin_16

Family

10

false

This family represents insect-selective, excitatory neurotoxins known as Janus atracotoxins or Lambda-hexatoxins, including the peptides secreted by the spider Hadronyche versuta (Blue mountains funnel-web spider) ( , , ). These toxins selectively inhibit invertebrate calcium-activated potassium (KCa, Slo-type) channel...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PROSITE" ]

[ "PF07945", "PS60020" ]

[ "Toxin_16", "J_ACTX" ]

[ 10, 10 ]

2

[ "PROSITEDOC" ]

[ "PDOC60020" ]

[ "PROSITEDOC:PDOC60020" ]

1

[ "1dl0" ]

1

[ "PUB00016591", "PUB00096652" ]

[ "10881200", "18625007" ]

[ "Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge.", "The Janus-faced atracotoxins are specific blockers of invertebrate K(Ca) channels." ]

[ 2000, 2008 ]

2

[]

0

null

[ "Hadronyche" ]

[ 10 ]

1

[]

0

true

Family

Janus-atracotoxin

Toxin_16

2

IPR012500

12,500

Clostridium neurotoxin, translocation

Toxin_trans

Domain

195

false

The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein: a N-terminal catalytic domain ( ), a central translocation domain and two receptor binding domains [ ]. Subsequent to cell surface bin...

[ "GO:0008320" ]

[ "protein transmembrane transporter activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07952" ]

[ "Toxin_trans" ]

[ 195 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.69", "GenProp0707", "R-HSA-5250955", "R-HSA-5250958", "R-HSA-5250968", "R-HSA-5250971", "R-HSA-5250981", "R-HSA-5250982", "R-HSA-5250989", "R-HSA-5250992" ]

[ "EC:3.4.24.69", "GP:GenProp0707", "REACTOME:R-HSA-5250955", "REACTOME:R-HSA-5250958", "REACTOME:R-HSA-5250968", "REACTOME:R-HSA-5250971", "REACTOME:R-HSA-5250981", "REACTOME:R-HSA-5250982", "REACTOME:R-HSA-5250989", "REACTOME:R-HSA-5250992" ]

10

[ "1epw", "1f31", "1g9a", "1g9b", "1g9c", "1g9d", "1i1e", "1s0b", "1s0c", "1s0d", "1s0e", "1s0f", "1s0g", "2np0", "2nyy", "2nz9", "2w2d", "2xhl", "3bta", "3ffz", "3v0a", "3v0b", "3v0c", "3zuq", "3zur", "3zus", "4zkt", "5bqm", "5bqn", "5n0b", "5n0c", "6dkk"...

59

[ "PUB00016466" ]

[ "9783750" ]

[ "Crystal structure of botulinum neurotoxin type A and implications for toxicity." ]

[ 1998 ]

1

[]

0

null

[ "Bacillota", "Cordyceps militaris", "unclassified Caudoviricetes" ]

[ 191, 1, 3 ]

3

[]

0

true

Domain

Clostridium neurotoxin, translocation

Toxin_trans

4

IPR012501

12,501

Vacuolar protein sorting-associated protein 54, C-terminal

Vps54_C

Domain

5,071

false

This entry represents a domain found in vacuolar protein sorting-associated protein 54 (VPS54), which acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). VPS54 is required to tether the complex to the TGN. However, it is not invo...

[ "GO:0042147" ]

[ "retrograde transport, endosome to Golgi" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF07928" ]

[ "Vps54" ]

[ 5071 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6811440", "R-HSA-6811440", "R-MMU-6811440", "R-RNO-6811440" ]

[ "REACTOME:R-DME-6811440", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-6811440", "REACTOME:R-RNO-6811440" ]

4

[]

0

[ "PUB00077150" ]

[ "25799061" ]

[ "EARP is a multisubunit tethering complex involved in endocytic recycling." ]

[ 2015 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5071 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 2, 1, 1, 4, 5, 1, 2, 3, 1, 24 ]

11

true

Domain

Vacuolar protein sorting-associated protein 54, C-terminal

Vps54_C

7

IPR012502

12,502

WAPL domain

WAPL_dom

Domain

2,948

false

The D. melanogaster WAPL protein regulates heterochromatin structure [ ]. It is required to hold sister chromatids of meiotic heterochromatin together and is implicated in both heterochromatin pairing during female meiosis and the modulation of position-effect variegation (PEV). Although the high-sequence conservation ...

[]

0

[ "PROFILE" ]

[ "PS51271" ]

[ "WAPL" ]

[ 2948 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-2468052", "R-CEL-2470946", "R-CEL-2500257", "R-DME-2468052", "R-DME-2470946", "R-DME-2500257", "R-HSA-2467813", "R-HSA-2468052", "R-HSA-2470946", "R-HSA-2500257", "R-MMU-2467813", "R-MMU-2468052", "R-MMU-2470946", "R-MMU-2500257" ]

[ "REACTOME:R-CEL-2468052", "REACTOME:R-CEL-2470946", "REACTOME:R-CEL-2500257", "REACTOME:R-DME-2468052", "REACTOME:R-DME-2470946", "REACTOME:R-DME-2500257", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2468052", "REACTOME:R-HSA-2470946", "REACTOME:R-HSA-2500257", "REACTOME:R-MMU-2467813", "REACTOM...

14

[ "4k6j" ]

1

[ "PUB00016495", "PUB00016544", "PUB00043751" ]

[ "10747063", "15150110", "15620708" ]

[ "Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster.", "Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression.", "A dioxin sensitive gene, mammalian WAP...

[ 2000, 2004, 2005 ]

3

[]

0

null

[ "Eukaryota", "Methanohalobium evestigatum (strain ATCC BAA-1072 / DSM 3721 / NBRC 107634 / OCM 161 / Z-7303)" ]

[ 2947, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]

[ 5, 3, 23, 5, 4, 3, 2 ]

7

true

Domain

WAPL domain

WAPL_dom

1

IPR012503

12,503

WisP, N-terminal

WisP_N

Domain

4

false

This family is found at the N terminus of the Tropheryma whipplei WisP family proteins [ ].

[]

0

[ "PFAM" ]

[ "PF07861" ]

[ "WND" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00016368" ]

[ "12606174" ]

[ "Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." ]

[ 2003 ]

1

[]

0

null

[ "Tropheryma whipplei" ]

[ 4 ]

1

[]

0

true

Domain

WisP, N-terminal

WisP_N

9

IPR012504

12,504

Spore protein YabP

Spore_YabP

Family

2,407

false

This protein family includes Spore protein YabP of the bacterial sporulation program, as found in Bacillus subtilis, Clostridium tetani, and other spore-forming members of the Firmicutes. In B. subtilis, a YabP single mutant appears to sporulate and germinate normally [ ], but is in an operon with YabQ (essential for f...

[ "GO:0030435" ]

[ "sporulation resulting in formation of a cellular spore" ]

[ "biological_process" ]

1

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF011576", "TIGR02892" ]

[ "YabP", "spore_yabP" ]

[ 2314, 2332 ]

2

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "2ks0", "2kyi", "3ipf" ]

3

[ "PUB00016405", "PUB00034419", "PUB00099797" ]

[ "15231775", "11283287", "21904870" ]

[ "Dynamic patterns of subcellular protein localization during spore coat morphogenesis in Bacillus subtilis.", "The Bacillus subtilis yabQ gene is essential for formation of the spore cortex.", "Solution NMR structure of Dsy0195 homodimer from Desulfitobacterium hafniense: first structure representative of the Y...

[ 2004, 2001, 2011 ]

3

[ "IPR022476" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 2388, 19 ]

2

[]

0

true

Family

Spore protein YabP

Spore_YabP

6

IPR012505

12,505

YbbR-like

YbbR

Family

6,983

false

This entry includes a group of bacterial proteins, including YbbR and CdaR. Bacillus subtilis CdaR regulates CdaA, a diadenylate cyclase that contributes to cell division [ ].

[]

0

[ "PFAM" ]

[ "PF07949" ]

[ "YbbR" ]

[ 6983 ]

1

[]

0

[ "2kq1", "2kxy", "2l3u", "4qdy", "5hqh" ]

5

[ "PUB00078871" ]

[ "26527648" ]

[ "Phenotypes Associated with the Essential Diadenylate Cyclase CdaA and Its Potential Regulator CdaR in the Human Pathogen Listeria monocytogenes." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Protostomia", "unclassified sequences" ]

[ 6882, 3, 98 ]

3

[]

0

true

Family

YbbR-like

YbbR

7

IPR012506

12,506

Lysoplasmalogenase-like

TMEM86B-like

Family

11,130

false

This entry represents a family of proteins that include lysoplasmalogenase from humans (also known as Transmembrane protein 86B, TMEM86B) and similar proteins found in eukaryotes and bacteria. TMEM86B catalyses the degradation of lysoplasmalogen, which is formed by the hydrolysis of membrane glycerophospholipids, plasm...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07947", "PTHR31885" ]

[ "YhhN", "" ]

[ 11092, 10067 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.3.2.2", "PWY-7783", "R-BTA-1482788", "R-DDI-1482788", "R-HSA-1482788", "R-MMU-1482788", "R-RNO-1482788", "R-SSC-1482788" ]

[ "EC:3.3.2.2", "METACYC:PWY-7783", "REACTOME:R-BTA-1482788", "REACTOME:R-DDI-1482788", "REACTOME:R-HSA-1482788", "REACTOME:R-MMU-1482788", "REACTOME:R-RNO-1482788", "REACTOME:R-SSC-1482788" ]

8

[]

0

[ "PUB00081209", "PUB00081210" ]

[ "21515882", "26335199" ]

[ "Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen.", "Large-scale determination of previously unsolved protein structures using evolutionary information." ]

[ 2011, 2015 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 8, 8196, 2855, 4, 67 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 4, 3, 1, 2, 4, 1, 6 ]

8

true

Family

Lysoplasmalogenase-like

TMEM86B-like

2

IPR012507

12,507

YibE/F-like

YibE_F

Family

7,765

false

The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE ( ) and YibF ( ). Most of the members of this family are annotated as being putative membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07907", "PTHR41771" ]

[ "YibE_F", "" ]

[ 7760, 7726 ]

2

[]

0

[]

0

[]

0

[]

[ "IPR014564" ]

0

1

0

[ "Aduncisulcus paluster", "Bacteria", "Methanocaldococcaceae", "metagenomes" ]

[ 1, 7703, 2, 59 ]

4

[]

0

true

Family

YibE/F-like

YibE_F

2

IPR012509

12,509

Neurotoxin 3, Anemonia

Neurotoxin_3_Anemonia

Domain

10

false

This entry occurs within the Anemonia sulcata toxin III (ATX III) neurotoxin family. ATX III is a neurotoxin that is produced by sea anemone; it adopts a compact structure containing four reverse turns and two other chain reversals, but no regular α-helix or β-sheet. A hydrophobic patch found on the surface of the pept...

[ "GO:0019871", "GO:0042151" ]

[ "sodium channel inhibitor activity", "nematocyst" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08098" ]

[ "ATX_III" ]

[ 10 ]

1

[]

0

[ "1ans" ]

1

[ "PUB00016365" ]

[ "7727358" ]

[ "Three-dimensional structure in solution of neurotoxin III from the sea anemone Anemonia sulcata." ]

[ 1994 ]

1

[]

0

null

[ "Actiniidae" ]

[ 10 ]

1

[]

0

true

Domain

Neurotoxin 3, Anemonia

Neurotoxin_3_Anemonia

4

IPR012511

12,511

S-adenosyl-l-methionine decarboxylase leader peptide

AdoMetDC_leader

Family

935

false

This family consists of the S-adenosyl-l-methionine decarboxylase (AdoMetDC) leader peptides. AdoMetDC is a key regulatory enzyme in the biosynthesis of polyamines. All expressed plant AdoMetDC mRNA 5, leader sequences contain a highly conserved pair of overlapping upstream ORFs (uORFs) that overlap by one base. Sequen...

[]

0

[ "PFAM" ]

[ "PF08132" ]

[ "AdoMetDC_leader" ]

[ 935 ]

1

[]

0

[]

0

[ "PUB00016511" ]

[ "11139406" ]

[ "Characterization of monocot and dicot plant S-adenosyl-l-methionine decarboxylase gene families including identification in the mRNA of a highly conserved pair of upstream overlapping open reading frames." ]

[ 2001 ]

1

[]

0

null

[ "Viridiplantae" ]

[ 935 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 4 ]

3

true

Family

S-adenosyl-l-methionine decarboxylase leader peptide

AdoMetDC_leader

2

IPR012512

12,512

Albumin I

Albumin_I

Family

184

false

The albumin I protein, a hormone-like peptide, stimulates kinase activity upon binding a membrane bound 43kDa receptor. The structure of this region reveals a knottin like fold, comprise of three β strands [ ].

[ "GO:0045735" ]

[ "nutrient reservoir activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF08027" ]

[ "Albumin_I" ]

[ 184 ]

1

[]

0

[ "1ju8", "1p8b", "8ahk" ]

3

[ "PUB00016533" ]

[ "12631285" ]

[ "A possible physiological function and the tertiary structure of a 4-kDa peptide in legumes." ]

[ 2003 ]

1

[]

0

null

[ "Pentapetalae" ]

[ 184 ]

1

[]

0

true

Family

Albumin I

Albumin_I

2

IPR012513

12,513

Metchnikowin

Mtk

Family

17

false

This family consists of the metchnikowin family of antimicrobial peptides from Drosophila. Metchnikowin is a proline-rich peptide whose expression is immune-inducible. Induction of the metchnikowin gene expression can be mediated either by the TOLL pathway or by the imd gene product. The metchnikowin peptide is unique ...

[ "GO:0019731", "GO:0019732" ]

[ "antibacterial humoral response", "antifungal humoral response" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF08105" ]

[ "Antimicrobial10" ]

[ 17 ]

1

[]

0

[]

0

[ "PUB00016474" ]

[ "9600835" ]

[ "Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin." ]

[ 1998 ]

1

[]

0

null

[ "Drosophila" ]

[ 17 ]

1

[ "Drosophila melanogaster" ]

[ 1 ]

1

true

Family

Metchnikowin

Mtk

7

IPR012514

12,514

Formaecin

Family

2

false

This entry consists of the formaecin family of antimicrobial peptides isolated from the bulldog ant Myrmecia gulosa in response to bacterial infection. Formaecins are inducible peptide antibiotics and are active against growing Escherichia coli but were inactive against other Gram-negative and Gram-positive bacteria. F...

[ "GO:0042381", "GO:0042742" ]

[ "hemolymph coagulation", "defense response to bacterium" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF08106" ]

[ "Antimicrobial11" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00016486" ]

[ "9497332" ]

[ "Isolation from an ant Myrmecia gulosa of two inducible O-glycosylated proline-rich antibacterial peptides." ]

[ 1998 ]

1

[]

0

null

[ "Myrmecia gulosa" ]

[ 2 ]

1

[]

0

true

Family

Formaecin

5

IPR012515

12,515

Pleurocidin

Antimicrobial12

Family

437

false

This family consists of the pleurocidin family of antimicrobial peptides. The first member identified in this family was Pleurocidin from the skin mucous secretions of the winter flounder (Pleuronectes americanus), peptides that exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria [ , ]. Pleu...

[ "GO:0042742" ]

[ "defense response to bacterium" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08107" ]

[ "Antimicrobial12" ]

[ 437 ]

1

[]

0

[ "2jos", "2mcu", "2mcv", "2ojm", "2ojn", "2ojo", "6pf0", "6rz1" ]

8

[ "PUB00016444", "PUB00038753", "PUB00097240" ]

[ "9115266", "15882067", "29108968" ]

[ "Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder.", "Structural characterization of the antimicrobial peptide pleurocidin from winter flounder.", "Identification of a moronecidin-like antimicrobial peptide in the venomous fish Pterois volitans: F...

[ 1997, 2005, 2018 ]

3

[]

0

null

[ "Acanthomorphata" ]

[ 437 ]

1

[]

0

true

Family

Pleurocidin

Antimicrobial12

3

IPR012516

12,516

Halocidin

Antimicrobial13

Family

3

false

This family consists of the halocidin family of antimicrobial peptides. Halocidins are isolated from the haemocytes of the tunicate, Halocynthia aurantium (Sea peach). They are dimeric in structures, which are found via a disulphide linkage between cysteines of two different- sized monomers. Halocidins have been shown ...

[ "GO:0042742" ]

[ "defense response to bacterium" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08108" ]

[ "Antimicrobial13" ]

[ 3 ]

1

[]

0

[]

0

[ "PUB00016429" ]

[ "12067731" ]

[ "Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium." ]

[ 2002 ]

1

[]

0

null

[ "Halocynthia aurantium" ]

[ 3 ]

1

[]

0

true

Family

Halocidin

Antimicrobial13

4

IPR012517

12,517

Lactocin 705

Antimicrobial14

Family

4

false

This family consists of lactocin 705 which is a bacteriocin produced by Lactobacillus casei CRL 705. Lactocin 705 is a class IIb bacteriocin, whose activity depends upon the complementation of two peptides (705-alpha and 705-beta) of 33 amino acid residues each. Lactocin 705 is active against several Gram-positive bact...

[]

0

[ "PFAM" ]

[ "PF08109" ]

[ "Antimicrobial14" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00016503" ]

[ "10754241" ]

[ "Identification and nucleotide sequence of genes involved in the synthesis of lactocin 705, a two-peptide bacteriocin from Lactobacillus casei CRL 705." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria" ]

[ 4 ]

1

[]

0

true

Family

Lactocin 705

Antimicrobial14

9

IPR012518

12,518

Ocellatin

Antimicrobial15

Domain

16

false

This family consists of the ocellatin family of antimicrobial peptides. Ocellatins are produced from the electrical-stimulated skin secretions of the South American frog, Leptodactylus ocellatus (Argus frog). The family consists of three structurally related peptides, ocellatin 1, ocellatin 2 and ocellatin 3 [ ]. These...

[ "GO:0019836", "GO:0005576" ]

[ "symbiont-mediated hemolysis of host erythrocyte", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08110" ]

[ "Antimicrobial15" ]

[ 16 ]

1

[]

0

[ "5u9q", "5u9r", "5u9s", "5u9v", "5u9x", "5u9y", "5ua6", "5ua7", "5ua8" ]

9

[ "PUB00016399", "PUB00094036", "PUB00094037" ]

[ "15648972", "12709067", "18539359" ]

[ "Ocellatins: new antimicrobial peptides from the skin secretion of the South American frog Leptodactylus ocellatus (Anura: Leptodactylidae).", "Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrob...

[ 2004, 2003, 2008 ]

3

[]

0

null

[ "Leptodactylus" ]

[ 16 ]

1

[]

0

true

Domain

Ocellatin

Antimicrobial15

1

IPR012519

12,519

Lantibiotic, type A, Pep5-type

Lantibiotic_typ-A_Pep5

Family

29

false

This family consists of the type A lantibiotic peptides. Both Pep5 and epicidin-280 are ribosomally-synthesised antimicrobial peptides produced by Gram-positive bacteria that are characterised by the presence of lanthionine and/or methyllanthionine residues. The lantibiotics family has a highly specific activity agains...

[]

0

[ "PFAM" ]

[ "PF08130" ]

[ "Antimicrobial18" ]

[ 29 ]

1

[]

0

[]

0

[ "PUB00016383", "PUB00016527" ]

[ "9726851", "2253617" ]

[ "Isolation, characterization, and heterologous expression of the novel lantibiotic epicidin 280 and analysis of its biosynthetic gene cluster.", "Biosynthesis of the lantibiotic Pep5. Isolation and characterization of a prepeptide containing dehydroamino acids." ]

[ 1998, 1990 ]

2

[]

0

null

[ "Bacillales" ]

[ 29 ]

1

[]

0

true

Family

Lantibiotic, type A, Pep5-type

Lantibiotic_typ-A_Pep5

3

IPR012520

12,520

Frog antimicrobial peptide, brevinin-1 type

Antimicrobial_frog_1

Domain

290

false

This family includes antimicrobial peptides secreted from skins of frogs. The secretion of antimicrobial peptides from the skins of frogs plays an important role in self defence. Structural analysis of these peptides showed that they can be classified into eight families [ ]. This is the brevinin-1 family, which includ...

[ "GO:0098542" ]

[ "defense response to other organism" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08018" ]

[ "Antimicrobial_1" ]

[ 290 ]

1

[]

0

[ "6g4i", "6g4k", "6g4u", "6g4v", "6g4x", "6r95", "6r96" ]

7

[ "PUB00016563", "PUB00094036" ]

[ "10651828", "12709067" ]

[ "Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.", "Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal pepti...

[ 2000, 2003 ]

2

[]

0

null

[ "Flagellimonas hymeniacidonis", "Ranoidea" ]

[ 1, 289 ]

2

[]

0

true

Domain

Frog antimicrobial peptide, brevinin-1 type

Antimicrobial_frog_1

1

IPR012521

12,521

Frog antimicrobial peptide, brevinin-2/esculentin type

Antimicrobial_frog_2

Domain

569

false

This family consists of the major classes of antimicrobial peptides secreted from the skin of frogs that protect the frogs against invading microbes. They are typically between 10-50 amino acids long and are derived from proteolytic cleavage of larger precursors. Major classes of peptides such esculentin, gaegurin, bre...

[ "GO:0006952", "GO:0005576" ]

[ "defense response", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08023" ]

[ "Antimicrobial_2" ]

[ 569 ]

1

[]

0

[ "2g9l", "2k10", "7p4x" ]

3

[ "PUB00016480" ]

[ "12470734" ]

[ "Antimicrobial peptides from amphibian skin: an expanding scenario." ]

[ 2002 ]

1

[]

0

null

[ "Neobatrachia", "Rhizobium chutanense" ]

[ 568, 1 ]

2

[]

0

true

Domain

Frog antimicrobial peptide, brevinin-2/esculentin type

Antimicrobial_frog_2

3

IPR012522

12,522

Spider antimicrobial peptide

Antimicrobial_3

Family

25

false

This family includes antimicrobial peptides isolated from the crude venom of the wolf spider Oxyopes kitabensis (Wolf spider). These peptides, known as oxyopinins, are the largest linear cationic amphipathic peptides chemically characterised and exhibit disrupting activities towards biological membranes [ ].

[ "GO:0019836", "GO:0005576" ]

[ "symbiont-mediated hemolysis of host erythrocyte", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08025" ]

[ "Antimicrobial_3" ]

[ 25 ]

1

[]

0

[]

0

[ "PUB00016580" ]

[ "11976325" ]

[ "Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins." ]

[ 2002 ]

1

[]

0

null

[ "Oxyopes" ]

[ 25 ]

1

[]

0

true

Family

Spider antimicrobial peptide

Antimicrobial_3

3

IPR012523

12,523

Ant antimicrobial peptide

Antimicrobial_4

Family

15

false

This family consists of the ponericin (also known as poneritoxin) family of antimicrobial peptides isolated from predatory ant Pachycondyla goeldii (Ponerine ant) and antimicrobial peptides from scorpion species [ ]. The ponericin peptides may adopt amphipathic α-helical structure in polar environments. In the ant colo...

[ "GO:0098542", "GO:0005576" ]

[ "defense response to other organism", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08024" ]

[ "Antimicrobial_4" ]

[ 15 ]

1

[]

0

[]

0

[ "PUB00013153", "PUB00016454" ]

[ "11279030", "11563967" ]

[ "Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii.", "Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Arthropoda" ]

[ 15 ]

1

[]

0

true

Family

Ant antimicrobial peptide

Antimicrobial_4

5

IPR012524

12,524

Abaecin, antimicrobial peptide

Abaecin_antimicrobial_peptide

Family

51

false

This entry represents antimicrobial peptides produced by bees. These peptides have strong antimicrobial and some anti-fungal activity and has homology to abaecin which is the largest proline-rich antimicrobial peptide isolated from European bumblebee Bombus pascuorum [ ].

[ "GO:0042381", "GO:0005576" ]

[ "hemolymph coagulation", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08026" ]

[ "Antimicrobial_5" ]

[ 51 ]

1

[]

0

[]

0

[ "PUB00016494" ]

[ "9219367" ]

[ "Novel antibacterial peptides isolated from a European bumblebee, Bombus pascuorum (Hymenoptera, Apoidea)." ]

[ 1997 ]

1

[]

0

null

[ "Aculeata" ]

[ 51 ]

1

[]

0

true

Family

Abaecin, antimicrobial peptide

Abaecin_antimicrobial_peptide

6

IPR012526

12,526

Scorpion antimicrobial peptide

Antimicrobial_7

Family

20

false

This family consists of antimicrobial peptides secreted by scorpions. Novel antimicrobial peptides have been isolated from scorpions, namely Opistoporin [ ], Pandinin [ ], Heterin [ ], Vejovine [ ] and Hadrurin [ ]. These peptides show amphipathic helical structures and demonstrate high antimicrobial activity [ ].

[ "GO:0042742", "GO:0044179", "GO:0005576" ]

[ "defense response to bacterium", "hemolysis in another organism", "extracellular region" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF08102" ]

[ "Antimicrobial_7" ]

[ 20 ]

1

[]

0

[]

0

[ "PUB00016371", "PUB00016454", "PUB00100329", "PUB00100330", "PUB00100331", "PUB00100332" ]

[ "12354111", "11563967", "24389272", "10931184", "20969885", "24184590" ]

[ "Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa.", "Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.", "Genomic and functional characterization of three new venom peptides from...

[ 2002, 2001, 2014, 2000, 2011, 2014 ]

6

[]

0

null

[ "Iurida", "Leifsonia poae" ]

[ 19, 1 ]

2

[]

0

true

Family

Scorpion antimicrobial peptide

Antimicrobial_7

3

IPR012527

12,527

Uperin

Antimicrobial_8

Family

7

false

This family consists of the uperin family of antimicrobial peptides. Uperin is a wide-spectrum antibiotic peptide isolated from the Australian toadlet, Uperoleia mjobergii. Being only 17 amino acid residues long, it is smaller than most other wide-spectrum antibiotic peptides isolated from amphibians. Uperin adopts a w...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF08103" ]

[ "Antimicrobial_8" ]

[ 7 ]

1

[]

0

[ "6gs3", "7qv5", "7s3e" ]

3

[ "PUB00016417" ]

[ "10461748" ]

[ "The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii." ]

[ 1999 ]

1

[]

0

null

[ "Uperoleia" ]

[ 7 ]

1

[]

0

true

Family

Uperin

Antimicrobial_8

5

IPR012528

12,528

Ponericin L

Antimicrobial_9

Family

3

false

This family consists of the ponericin L family (also known as poneritoxin) of antimicrobial peptides that are isolated from the venom of the predatory ant Pachycondyla goeldii (Ponerine ant). Ponericin L family shares similarities with dermaseptins. Ponericin L may adopt an amphipathic α-helical structure in polar envi...

[ "GO:0045087", "GO:0005576" ]

[ "innate immune response", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08104" ]

[ "Antimicrobial_9" ]

[ 3 ]

1

[]

0

[]

0

[ "PUB00013153" ]

[ "11279030" ]

[ "Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii." ]

[ 2001 ]

1

[]

0

null

[ "Neoponera" ]

[ 3 ]

1

[]

0

true

Family

Ponericin L

Antimicrobial_9

3

IPR012529

12,529

Attractin

Family

5

false

This family consists of the attractin family of water-borne pheromone. Mate attraction in Aplysia involves a long-distance water-borne signal in the form of the attractin peptide that is released during egg laying. These peptides contain 6 conserved cysteines and are folded into 2 antiparallel helices. The second helix...

[ "GO:0000772", "GO:0019953", "GO:0005576" ]

[ "mating pheromone activity", "sexual reproduction", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF08037" ]

[ "Attractin" ]

[ 5 ]

1

[]

0

[ "1t50" ]

1

[ "PUB00016447" ]

[ "15118100" ]

[ "Structural and functional analysis of Aplysia attractins, a family of water-borne protein pheromones with interspecific attractiveness." ]

[ 2004 ]

1

[]

0

null

[ "Aplysia" ]

[ 5 ]

1

[]

0

true

Family

Attractin

9

IPR012530

12,530

B melanoma antigen-like

BAGE-like

Family

354

false

This family consists of the B melanoma antigen (BAGE) peptides. The BAGE gene encodes a human tumour antigen that is recognised by a cytolytic T lymphocyte. BAGE genes are expressed in melanomas, bladder and lung carcinomas and in a few tumours of other histological types [ ]. This entry also includes bacterial protein...

[]

0

[ "PFAM" ]

[ "PF08180" ]

[ "BAGE" ]

[ 354 ]

1

[]

0

[]

0

[ "PUB00016540" ]

[ "12461691" ]

[ "New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Catarrhini" ]

[ 347, 7 ]

2

[ "Homo sapiens" ]

[ 6 ]

1

true

Family

B melanoma antigen-like

BAGE-like

3

IPR012532

12,532

BDHCT

Domain

1,085

false

This is a C-terminal domain in RecQ-like DNA helicase BLM subfamily [ ]. The helicase participates in DNA replication and repair, exhibiting a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.

[ "GO:0003677", "GO:0005524", "GO:0016818", "GO:0006260", "GO:0005634" ]

[ "DNA binding", "ATP binding", "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "DNA replication", "nucleus" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PFAM" ]

[ "PF08072" ]

[ "BDHCT" ]

[ 1085 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "5.6.2.4", "R-HSA-174414", "R-HSA-3108214", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693554", "R-HSA-5693568", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-912446", "R-HSA-9701192", "R-HSA-9704331", "R-HSA-9704646", "R-HSA-9709570", "R-...

[ "EC:5.6.2.4", "REACTOME:R-HSA-174414", "REACTOME:R-HSA-3108214", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693554", "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-5693579", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473...

28

[ "5lup", "5lus", "5lut", "5mk5" ]

4

[ "PUB00016366" ]

[ "15112237" ]

[ "Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire." ]

[ 2004 ]

1

[]

0

null

[ "Gnathostomata" ]

[ 1085 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 8, 2, 4 ]

4

true

Domain

BDHCT

7

IPR012533

12,533

YncI, copper-binding domain

YcnI-copper_dom

Domain

6,610

false

The ycnKJI operon is responsible for regulating copper levels in the Gram-positive bacterium Bacillus subtilis [ ]. This operon encodes three Cu-related proteins: a copper-dependent transcriptional repressor (YcnK), a putative copper importer (YcnJ), and a copper-binding protein of unknown function (YcnI). YcnI's extra...

[]

0

[ "PFAM", "CDD" ]

[ "PF07987", "cd08545" ]

[ "DUF1775", "YcnI_like" ]

[ 6610, 5597 ]

2

[]

0

[ "3esm", "7me6", "7mek", "8um6" ]

4

[ "PUB00066868", "PUB00160353" ]

[ "19168619", "38342077" ]

[ "Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis.", "Stabilization of a Cu-binding site by a highly conserved tryptophan residue." ]

[ 2009, 2024 ]

2

[]

0

null

[ "Bacteria", "Caldiarchaeum subterraneum", "Eukaryota", "metagenomes" ]

[ 6416, 1, 141, 52 ]

4

[]

0

true

Domain

YncI, copper-binding domain

YcnI-copper_dom

2

IPR012534

12,534

Bombolitin

Family

4

false

This family consists of the bombolitin peptides that are found in the venom of the bumblebee Megabombus pennsylvanicus (American common bumblebee). Bombolitins are structurally and functionally very similar. They lyse erythrocytes and liposomes, release histamine from rat peritoneal mast cells, and stimulate phospholip...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF08096" ]

[ "Bombolitin" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00016434" ]

[ "2578459" ]

[ "Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus." ]

[ 1985 ]

1

[]

0

null

[ "Bombus pensylvanicus" ]

[ 4 ]

1

[]

0

true

Family

Bombolitin

9

IPR012535

12,535

Cell division protein Cdc14

Cell_div_Cdc14

Family

2,202

false

Cdc14 is a component of the septation initiation network (SIN) and is required for the localisation and activity of Sid1. Sid1 is a protein kinase that localises asymmetrically to one spindle pole body (SPB) in anaphase disappears prior to cell separation [ ], [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08045", "PTHR34065" ]

[ "CDC14", "" ]

[ 2012, 2156 ]

2

[]

0

[]

0

[ "PUB00016483", "PUB00016499" ]

[ "10775265", "11384993" ]

[ "The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast.", "Interaction between the noncatalytic region of Sid1p kinase and Cdc14p is required for full catalytic activity and localization of Sid1p." ]

[ 2000, 2001 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2202 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 3, 1, 7, 1, 6 ]

5

true

Family

Cell division protein Cdc14

Cell_div_Cdc14

7

IPR012536

12,536

Cytomegalovirus US glycoprotein

CMV_US

Family

227

false

This is a family of unique short (US) cytoplasmic glycoproteins which are expressed in cytomegalovirus [ ]. In human bodies, US11 participates in the inhibition of the host immune response. It redirects newly synthesized MHC class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-depe...

[ "GO:0052031", "GO:0044167" ]

[ "symbiont-mediated perturbation of host defense response", "host cell endoplasmic reticulum membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08001" ]

[ "CMV_US" ]

[ 227 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-8866654", "R-HSA-9609690" ]

[ "REACTOME:R-HSA-8866654", "REACTOME:R-HSA-9609690" ]

2

[]

0

[ "PUB00016601", "PUB00064977", "PUB00064978", "PUB00064979" ]

[ "11992003", "8625414", "8855296", "12224515" ]

[ "Human cytomegalovirus US7, US8, US9, and US10 are cytoplasmic glycoproteins, not found at cell surfaces, and US9 does not mediate cell-to-cell spread.", "The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol.", "Human cytomegalovirus inhib...

[ 2002, 1996, 1996, 2002 ]

4

[]

0

null

[ "Cytomegalovirus" ]

[ 227 ]

1

[]

0

true

Family

Cytomegalovirus US glycoprotein

CMV_US

1

IPR012537

12,537

Chloramphenicol resistance gene leader peptide

Cmp-R_leader

Family

19

false

This family consists of chloramphenicol (Cm) resistance gene leader peptides. Inducible resistance to Cm in both Gram-positive and Gram-negative bacteria is controlled by translation attenuation. In translation attenuation, the ribosome-binding-site (RBS) for the resistance determinant is sequestered in a secondary str...

[]

0

[ "PFAM" ]

[ "PF08077" ]

[ "Cm_res_leader" ]

[ 19 ]

1

[]

0

[]

0

[ "PUB00016381" ]

[ "8955642" ]

[ "Translation attenuation regulation of chloramphenicol resistance in bacteria--a review." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria" ]

[ 19 ]

1

[]

0

true

Family

Chloramphenicol resistance gene leader peptide

Cmp-R_leader

8

IPR012538

12,538

Cytochrome c oxidase polypeptide 2A

Cyt_c_oxidase_su2a

Family

381

false

This family consists of the cytochrome c oxidase polypeptide 2A family. The ba3-type cytochrome c oxidase from Thermus thermophilus is known as a two subunit enzyme. From its crystal structure, it was discovered that an additional transmembrane helix, subunit IIa, spans the membrane. This subunit consists of 34 residue...

[]

0

[ "PFAM" ]

[ "PF08113" ]

[ "CoxIIa" ]

[ 381 ]

1

[]

0

[ "1ehk", "1xme", "2qpd", "2qpe", "3bvd", "3eh3", "3eh4", "3eh5", "3qjq", "3qjr", "3qjs", "3qjt", "3qju", "3qjv", "3s33", "3s38", "3s39", "3s3a", "3s3b", "3s3c", "3s3d", "3s8f", "3s8g", "4fa7", "4faa", "4g70", "4g71", "4g72", "4g7q", "4g7r", "4g7s", "4gp4"...

41

[ "PUB00016386" ]

[ "11152118" ]

[ "Primary structure of a novel subunit in ba3-cytochrome oxidase from Thermus thermophilus." ]

[ 2000 ]

1

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 2, 376, 3 ]

3

[]

0

true

Family

Cytochrome c oxidase polypeptide 2A

Cyt_c_oxidase_su2a

1

IPR012539

12,539

Crustacean cuticle

Cuticle_1

Family

108

false

This family consists of the cuticle proteins from the Cancer pagurus (Rock crab) and the Homarus americanus (American lobster). These proteins are isolated from the calcified regions of the crustacean and they contain two copies of an 18 residue sequence motif, which thus far has been found only in crustacean calcified...

[ "GO:0042302" ]

[ "structural constituent of cuticle" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF08140" ]

[ "Cuticle_1" ]

[ 108 ]

1

[]

0

[]

0

[ "PUB00016398" ]

[ "10425740" ]

[ "Exoskeletal proteins from the crab, Cancer pagurus." ]

[ 1999 ]

1

[]

0

null

[ "Eumalacostraca" ]

[ 108 ]

1

[]

0

true

Family

Crustacean cuticle

Cuticle_1

7

IPR012540

12,540

Cuticle 7 isoform

Cuticle_2

Family

3

false

This family consists of cuticle protein 7 isoforms that are isolated from the carapace cuticle of a juvenile horseshoe crab, Limulus polyphemus. There are 3 isoforms of cuticle protein 7. The 3 isoforms are N-terminally blocked but could be deblocked by treatment with pyroglutaminase, showing that the N-terminal residu...

[ "GO:0042302" ]

[ "structural constituent of cuticle" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF08184" ]

[ "Cuticle_2" ]

[ 3 ]

1

[]

0

[]

0

[ "PUB00016524" ]

[ "12628379" ]

[ "Cuticular proteins from the horseshoe crab, Limulus polyphemus." ]

[ 2003 ]

1

[]

0

null

[ "Limulus polyphemus" ]

[ 3 ]

1

[]

0

true

Family

Cuticle 7 isoform

Cuticle_2

7

IPR012541

12,541

DBP10, C-terminal

DBP10_C

Domain

4,377

false

This group of DEAD-box RNA helicases includes Dbp10 from fungi, DDX54 (also known as DP97) from mammals and RH29 from plants. DDX54 interacts in a hormone-dependent manner with nuclear receptors [ , ]. It plays an important role in central nervous system myelination [ ]. Dbp10 has a role in ribosome biogenesis [ ]. RH2...

[ "GO:0003723", "GO:0003724", "GO:0005524", "GO:0005634" ]

[ "RNA binding", "RNA helicase activity", "ATP binding", "nucleus" ]

[ "molecular_function", "molecular_function", "molecular_function", "cellular_component" ]

4

[ "PFAM", "SMART" ]

[ "PF08147", "SM01123" ]

[ "DBP10CT", "DBP10CT" ]

[ 4304, 4339 ]

2

[ "EC" ]

[ "3.6.4.13" ]

[ "EC:3.6.4.13" ]

1

[ "8fkt", "8fku", "8fkv", "8fkw", "8fkx", "8fky", "8i9v", "8i9w", "8i9x", "8v84", "8v85", "8v87" ]

12

[ "PUB00016366", "PUB00078979", "PUB00078980", "PUB00101739", "PUB00101740", "PUB00101741" ]

[ "15112237", "23239230", "10871363", "12466272", "22910411", "32280991" ]

[ "Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.", "A DEAD-box RNA helicase Ddx54 protein in oligodendrocytes is indispensable for myelination in the central nervous system.", "Dbp10p, a putative RNA helicase from Saccharomyces cerevisiae, is required for ribosome b...

[ 2004, 2013, 2000, 2003, 2012, 2020 ]

6

[]

0

null

[ "Eukaryota" ]

[ 4377 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 2, 1, 2, 6, 1, 1, 3, 1, 1, 3 ]

12

true

Domain

DBP10, C-terminal

DBP10_C

4

IPR012542

12,542

DTHCT

Domain

1,900

false

The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins [ ]. This region is composed of quite low complexity sequence.

[]

0

[ "PFAM" ]

[ "PF08070" ]

[ "DTHCT" ]

[ 1900 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.2", "R-HSA-1362277", "R-HSA-4615885", "R-MMU-4615885", "R-RNO-4615885", "R-SSC-4615885" ]

[ "EC:5.6.2.2", "REACTOME:R-HSA-1362277", "REACTOME:R-HSA-4615885", "REACTOME:R-MMU-4615885", "REACTOME:R-RNO-4615885", "REACTOME:R-SSC-4615885" ]

6

[ "6zy5", "6zy6", "6zy7", "6zy8", "7yq8" ]

5

[ "PUB00016366" ]

[ "15112237" ]

[ "Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1900 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 8, 5, 6 ]

4

true

Domain

DTHCT

8

IPR012544

12,544

Bacterial Pleckstrin homology domain

PHb

Domain

6,012

false

This domain can be found in many bacterial hypothetical proteins. The structures of , , and , , show similarities to the PH or pleckstrin homology domain. The first evidence of PH-like domains in bacteria suggests a role in cell envelope stress response [ ].

[]

0

[ "PFAM" ]

[ "PF08000" ]

[ "bPH_1" ]

[ 6012 ]

1

[]

0

[ "3b77", "3dcx", "3hsa" ]

3

[ "PUB00054230" ]

[ "19913036" ]

[ "Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 5740, 5, 222, 23, 22 ]

5

[]

0

true

Domain

Bacterial Pleckstrin homology domain

PHb

8

IPR012545

12,545

Protein of unknown function DUF1697

DUF1697

Family

8,534

false

This family contains many hypothetical bacterial proteins.

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF08002", "PIRSF008502", "PTHR36439" ]

[ "DUF1697", "UCP008502", "" ]

[ 8530, 7893, 8377 ]

3

[]

0

[ "2hiy" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 30, 8373, 67, 64 ]

4

[]

0

true

Family

Protein of unknown function DUF1697

DUF1697

2

IPR012546

12,546

Domain of unknown function DUF1699

DUF1699

Domain

412

false

This family contains many archaeal proteins which have very conserved sequences.

[]

0

[ "PFAM" ]

[ "PF08004" ]

[ "DUF1699" ]

[ 412 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanomicrobia", "ecological metagenomes" ]

[ 402, 10 ]

2

[]

0

true

Domain

Domain of unknown function DUF1699

DUF1699

8

IPR012547

12,547

PD-(D/E)XK nuclease superfamily 9

PDDEXK_9

Family

8,689

false

This family contains many hypothetical bacterial proteins. It has been identified as a member of the PD-(D/E)XK nuclease superfamily through transitive meta profile searches. Proteins in this family have the predicted secondary structure pattern of the restriction endonuclease-like fold core and contains an additional ...

[]

0

[ "PFAM" ]

[ "PF08011" ]

[ "PDDEXK_9" ]

[ 8689 ]

1

[]

0

[]

0

[ "PUB00044133" ]

[ "17584917" ]

[ "Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families with modified transitive meta profile searches." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 130, 8144, 340, 2, 73 ]

5

[]

0

true

Family

PD-(D/E)XK nuclease superfamily 9

PDDEXK_9

7

IPR012548

12,548

Microtubule-associated tyrosine carboxypeptidase

MATCAP

Family

4,891

false

This entry includes microtubule-associated tyrosine carboxypeptidases, proteins that remove the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function [ ]. They are also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8 [ ]. These proteins recognise a...

[]

0

[ "PFAM", "PANTHER", "SMART" ]

[ "PF08014", "PTHR31817", "SM01154" ]

[ "MATCAP", "", "DUF1704" ]

[ 4639, 4811, 4736 ]

3

[ "EC" ]

[ "3.4.17.17" ]

[ "EC:3.4.17.17" ]

1

[ "7z5g", "7z5h", "7z6s" ]

3

[ "PUB00101358" ]

[ "35482892" ]

[ "Posttranslational modification of microtubules by the MATCAP detyrosinase." ]

[ 2022 ]

1

[]

[ "IPR012656" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 8, 2970, 1894, 19 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 9, 4, 9 ]

4

true

Family

Microtubule-associated tyrosine carboxypeptidase

MATCAP

9

IPR012549

12,549

Phosphoethanolamine transferase, N-terminal

EptA-like_N

Domain

7,910

false

This entry represents a domain found in a group of bacterial phosphoethanolamine transferases, including EptA from Helicobacter pylori [ ] and Neisseria meningitidis [ ], and EptA/EptB/EptC from Escherichia coli [ ]. This domain is found immediately N-terminal to the sulphatase domain in many sulphatases. The structure...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF08019" ]

[ "EptA_B_N" ]

[ 7910 ]

1

[]

0

[ "5fgn" ]

1

[ "PUB00084966", "PUB00084967", "PUB00092987" ]

[ "15489235", "15795227", "28193899" ]

[ "Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A.", "A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion...

[ 2004, 2005, 2017 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7807, 9, 94 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Phosphoethanolamine transferase, N-terminal

EptA-like_N

3

IPR012550

12,550

Protein of unknown function DUF1706

DUF1706

Family

2,950

false

This family contains many hypothetical proteins from bacteria and yeast. Proteins in this entry include Irc4 (increased recombination centres 4) from budding yeast [ ].

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF08020", "PIRSF031551", "PTHR40658" ]

[ "DUF1706", "DUF1706", "" ]

[ 2950, 2355, 2765 ]

3

[]

0

[ "4n6c", "5civ", "5cof", "5cog", "5com", "5cqv", "6anr", "7mtl", "7mtt" ]

9

[ "PUB00077036" ]

[ "18085829" ]

[ "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Candidatus Heimdallarchaeum", "Saccharomyces", "metagenomes" ]

[ 2920, 2, 10, 18 ]

4

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1706

DUF1706

8

IPR012551

12,551

DUF1707 SHOCT-like domain

DUF1707_SHOCT-like

Domain

13,952

false

This domain is found in a variety of actinomycetales proteins. All of the proteins containing this domain are uncharcterised and probably membrane bound or associated. Currently, it is unclear to the function of this domain.

[]

0

[ "PFAM" ]

[ "PF08044" ]

[ "DUF1707" ]

[ 13952 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Rhynchospora breviuscula", "Salinadaptatus halalkaliphilus", "metagenomes" ]

[ 13922, 1, 1, 28 ]

4

[]

0

true

Domain

DUF1707 SHOCT-like domain

DUF1707_SHOCT-like

5

IPR012552

12,552

DVL

Family

3,676

false

This family consists of the DVL family of proteins. In a gain-of-function genetic screen for genes that influence fruit development in Arabidopsis, DEVIL (DVL) gene was identified. DVL (also known as Small polypeptide ROTUNDIFOLIA) is a small protein and over expression of the protein results in pleiotropic phenotypes ...

[ "GO:0008285" ]

[ "negative regulation of cell population proliferation" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08137" ]

[ "DVL" ]

[ 3676 ]

1

[]

0

[]

0

[ "PUB00016535", "PUB00097929", "PUB00097930" ]

[ "14871303", "25701405", "22112938" ]

[ "DVL, a novel class of small polypeptides: overexpression alters Arabidopsis development.", "Comparative analysis of the RTFL peptide family on the control of plant organogenesis.", "DVL genes play a role in the coordination of socket cell recruitment and differentiation." ]

[ 2004, 2015, 2012 ]

3

[]

0

null

[ "Dorea formicigenerans", "Embryophyta" ]

[ 2, 3674 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 50, 28, 39 ]

3

true

Family

DVL

7

IPR012553

12,553

Defensin-like peptide

Defensin_3

Family

41

false

This family consists of the defensin-like peptides (DLPs) isolated from duckbill platypus (Ornithorhynchus anatinus) venom. These DLPs show similar three-dimensional fold to that of beta-defensin-12 and sodium-channel neurotoxin Shl. However the side chains known to be functionally important to beta-defensin-12 and Shl...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF08131" ]

[ "Defensin_3" ]

[ 41 ]

1

[]

0

[ "1b8w", "1d6b", "1zue", "1zuf" ]

4

[ "PUB00016482", "PUB00097073" ]

[ "10417345", "16480722" ]

[ "Solution structure of a defensin-like peptide from platypus venom.", "Mammalian l-to-d-amino-acid-residue isomerase from platypus venom." ]

[ 1999, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 10, 31 ]

2

[]

0

true

Family

Defensin-like peptide

Defensin_3

4

IPR012554

12,554

Degradation enzyme regulation protein DegQ

DegQ

Family

81

false

This family consists of the DegQ (formerly sacQ) regulatory peptides. The DegQ family of peptides control the rates of synthesis of a class of both secreted and intracellular degradative enzymes in Bacillus subtilis and related bacteria [ , , ]. DegQ is 46 amino acids long and activates the synthesis of degradative enz...

[ "GO:1900192" ]

[ "positive regulation of single-species biofilm formation" ]

[ "biological_process" ]

1

[ "NCBIFAM", "PFAM" ]

[ "NF041457", "PF08181" ]

[ "reg_protDegQ_Bacil", "DegQ" ]

[ 65, 81 ]

2

[]

0

[ "9vlh", "9vli" ]

2

[ "PUB00016418", "PUB00077037", "PUB00151319", "PUB00151320", "PUB00151479" ]

[ "1688843", "17850253", "26302846", "17827323", "34713601" ]

[ "Signal transduction pathway controlling synthesis of a class of degradative enzymes in Bacillus subtilis: expression of the regulatory genes and analysis of mutations in degS and degU.", "Gradual activation of the response regulator DegU controls serial expression of genes for flagellum formation and biofilm for...

[ 1990, 2007, 2015, 2007, 2021 ]

5

[]

0

null

[ "Bacteria", "Piromyces finnis" ]

[ 80, 1 ]

2

[]

0

true

Family

Degradation enzyme regulation protein DegQ

DegQ

5

IPR012555

12,555

Major transforming E5

EPV_E5

Family

46

false

This family consists of the major transforming proteins (E5) of the bovine papilloma virus (BPV). The equine sarcoid is one of the most common dermatological lesion in equids. It is a benign, locally invasive dermal fibroblastic lesion and studies have shown an association of the lesions with BPV. E5 is a short hydroph...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF08135", "PIRSF003401" ]

[ "EPV_E5", "EPV_E5" ]

[ 46, 39 ]

2

[]

0

[]

0

[ "PUB00016416" ]

[ "12951274" ]

[ "Sequence variants of bovine papillomavirus E5 detected in equine sarcoids." ]

[ 2003 ]

1

[]

0

null

[ "Papillomaviridae", "Strongylocentrotus purpuratus" ]

[ 45, 1 ]

2

[]

0

true

Family

Major transforming E5

EPV_E5

6

IPR012556

12,556

Entericidin A/B

Entericidin

Family

5,655

false

This family consists of the entericidin antidote/toxin peptides. The entericidin locus is activated in stationary phase under high osmolarity conditions by rho-S and simultaneously repressed by the osmoregulatory EnvZ/OmpR signal transduction pathway. The entericidin locus encodes tandem paralogous genes (ecnAB) and di...

[ "GO:0009636", "GO:0016020" ]

[ "response to toxic substance", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08085" ]

[ "Entericidin" ]

[ 5655 ]

1

[ "GP" ]

[ "GenProp0321" ]

[ "GP:GenProp0321" ]

1

[]

0

[ "PUB00016456", "PUB00078788" ]

[ "9677290", "25381243" ]

[ "The entericidin locus of Escherichia coli and its implications for programmed bacterial cell death.", "Entericidin is required for a probiotic treatment (Enterobacter sp. strain C6-6) to protect trout from cold-water disease challenge." ]

[ 1998, 2015 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 5625, 3, 27 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Entericidin A/B

Entericidin

3

IPR012557

12,557

Heat stable enterotoxin, EAST1

Heat-stable_enterotox_EAST1

Family

21

false

Heat-stable toxin 1 of entero-aggregative Escherichia coli (EAST1) is a small toxin. It is not, however, solely associated with entero-aggregative E. coli but also with many other diarrhoeic E. coli families. Some studies have established the role of EAST1 in some human outbreaks of diarrhoea. Isolates from farm animal...

[]

0

[ "PFAM" ]

[ "PF08090" ]

[ "Enterotoxin_HS1" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00035776" ]

[ "16336921" ]

[ "Presence of Escherichia coli carrying the EAST1 toxin gene in farm animals." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria" ]

[ 21 ]

1

[]

0

true

Family

Heat stable enterotoxin, EAST1

Heat-stable_enterotox_EAST1

8

IPR012558

12,558

Erythromycin resistance leader peptide-1

Emycin-R_leader_pep1

Family

30

false

This family consists of erythromycin resistance gene leader peptides. These leader peptides are involved in the translational attenuation of erythromycin resistance genes. Interestingly, the consensus sequence of peptides conferring erythromycin resistance is similar to that of the leader peptides, thus indicating that...

[]

0

[ "PFAM" ]

[ "PF08051" ]

[ "Ery_res_leader1" ]

[ 30 ]

1

[]

0

[]

0

[ "PUB00016432" ]

[ "11587794" ]

[ "Short peptides conferring resistance to macrolide antibiotics." ]

[ 2001 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 30 ]

1

[]

0

true

Family

Erythromycin resistance leader peptide-1

Emycin-R_leader_pep1

7

IPR012559

12,559

Erythromycin resistance leader peptide-2

Emycin-R_leader_pep2

Family

31

false

This family consists of erythromycin resistance gene leader peptides. These leader peptides are involved in the transcriptional attenuation control of the synthesis of the macrolide-lincosamide -streptogramin B resistance protein. It acts as a transcriptional attenuator, in contrast to other inducible erm genes. The mR...

[ "GO:0046677" ]

[ "response to antibiotic" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08057" ]

[ "Ery_res_leader2" ]

[ 31 ]

1

[]

0

[]

0

[ "PUB00016534" ]

[ "1713206" ]

[ "Transcriptional attenuation control of ermK, a macrolide-lincosamide-streptogramin B resistance determinant from Bacillus licheniformis." ]

[ 1991 ]

1

[]

0

null

[ "Bacillota" ]

[ 31 ]

1

[]

0

true

Family

Erythromycin resistance leader peptide-2

Emycin-R_leader_pep2

7

IPR012560

12,560

Ferlin A-domain

Ferlin_A-domain

Domain

4,885

false

The ferlin gene family are characterised by multiple tandem C2 domains and a C-terminal transmembrane domain. They are found in a wide range of species and their function remains unknown, however, mutations in its two most well-characterised members, dysferlin and otoferlin, have been implicated in human disease [ ]. T...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "SMART" ]

[ "PF08165", "SM01200" ]

[ "FerA", "FerA" ]

[ 4750, 4837 ]

2

[ "REACTOME" ]

[ "R-HSA-445355" ]

[ "REACTOME:R-HSA-445355" ]

1

[ "9b8k", "9b8l", "9h6x", "9qkv", "9qle", "9qlf", "9qln", "9qls" ]

8

[ "PUB00016366", "PUB00054013" ]

[ "15112237", "20667140" ]

[ "Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.", "Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins." ]

[ 2004, 2010 ]

2

[]

0

null

[ "Metazoa" ]

[ 4885 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 43, 6, 17, 17 ]

5

true

Domain

Ferlin A-domain

Ferlin_A-domain

6

IPR012561

12,561

Ferlin B-domain

Ferlin_B-domain

Domain

9,379

false

The ferlin gene family are characterised by multiple tandem C2 domains and a C-terminal transmembrane domain. They are found in a wide range of species and their function remains unknown, however, mutations in its two most well-characterised members, dysferlin and otoferlin, have been implicated in human disease [ ]. T...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "SMART" ]

[ "PF08150", "SM01201" ]

[ "FerB", "FerB" ]

[ 9362, 9374 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-445355", "R-HSA-9609523", "R-HSA-9662360" ]

[ "REACTOME:R-HSA-445355", "REACTOME:R-HSA-9609523", "REACTOME:R-HSA-9662360" ]

3

[ "9b8k", "9b8l", "9h6x", "9qe2", "9qkv", "9qle", "9qlf", "9qln", "9qls", "9se5", "9sea", "9seg", "9sfl", "9sh0", "9si1" ]

15

[ "PUB00016366", "PUB00054013" ]

[ "15112237", "20667140" ]

[ "Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.", "Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins." ]

[ 2004, 2010 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 9379 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 104, 10, 26, 27 ]

5

true

Domain

Ferlin B-domain

Ferlin_B-domain

8

IPR012564

12,564

Herpesvirus UL74, glycoprotein

Herpes_UL74

Family

563

false

Members of this family are viral glycoproteins that form part of an envelope complex [ ].

[]

0

[ "PFAM" ]

[ "PF07982" ]

[ "Herpes_UL74" ]

[ 563 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "7lbe", "7lbf", "7lbg", "7ram", "8tco" ]

5

[ "PUB00016476" ]

[ "9733861" ]

[ "The human cytomegalovirus UL74 gene encodes the third component of the glycoprotein H-glycoprotein L-containing envelope complex." ]

[ 1998 ]

1

[]

0

null

[ "Betaherpesvirinae" ]

[ 563 ]

1

[]

0

true

Family

Herpesvirus UL74, glycoprotein

Herpes_UL74

4

IPR012565

12,565

Histidine operon leader peptide

His_leader

Family

590

false

This family consists of the leader peptide of the histidine (his) operon. The his operon contains all the genes necessary for histidine biosynthesis. The region corresponding to the untranslated 5'-end of the transcript, named the his leader region, displays the typical features of the T box transcriptional attenuation...

[ "GO:0000105" ]

[ "L-histidine biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08047" ]

[ "His_leader" ]

[ 590 ]

1

[ "GP" ]

[ "GenProp0109" ]

[ "GP:GenProp0109" ]

1

[]

0

[ "PUB00016413" ]

[ "10094678" ]

[ "Regulation of expression of the Lactococcus lactis histidine operon." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria" ]

[ 590 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Histidine operon leader peptide

His_leader

1

IPR012566

12,566

IlvB leader peptide

IlvB_leader

Family

571

false

This family consists of the leader peptides of the ilvB operon. This operon contains the structural gene for acetohydroxy acid synthase I, an enzyme required for the biosynthesis of valine and isoleucine. The DNA sequence of the ilvB operon promoter-control region encodes a potential leader polypeptide containing 32 am...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007579", "PF08049" ]

[ "PRK10214.1", "IlvB_leader" ]

[ 380, 571 ]

2

[]

0

[]

0

[ "PUB00016464" ]

[ "6292893" ]

[ "Nucleotide sequence of the ilvB promoter-regulatory region: a biosynthetic operon controlled by attenuation and cyclic AMP." ]

[ 1982 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 571 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

IlvB leader peptide

IlvB_leader

8

IPR012567

12,567

IlvGEDA operon leader peptide

IlvGEDA_leader

Family

710

false

This family consists of the leader peptides of ilvGEDA operon. The expression of the ilvGEDA operon of E coli K-12 is multivalently controlled by the three branched -chain amino acids. Regulation is thought to occur by attenuation of transcription in response to the changing levels of the cognate tRNAs. Transcription o...

[ "GO:0009082" ]

[ "branched-chain amino acid biosynthetic process" ]

[ "biological_process" ]

1

[ "NCBIFAM", "PFAM" ]

[ "NF007744", "PF08046" ]

[ "PRK10424.1", "IlvGEDA_leader" ]

[ 679, 710 ]

2

[]

0

[]

0

[ "PUB00016507" ]

[ "3900037" ]

[ "Comparison of the regulatory regions of ilvGEDA operons from several enteric organisms." ]

[ 1985 ]

1

[]

0

null

[ "Bacteria" ]

[ 710 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

IlvGEDA operon leader peptide

IlvGEDA_leader

4

IPR012568

12,568

KI67R

Repeat

1,044

false

This entry represents the KI67/Chmadrin repeat [ ]. It can be found in the human antigen KI-67 protein [ ]. The function of this repeat is unknown.

[]

0

[ "PFAM", "SMART" ]

[ "PF08065", "SM01295" ]

[ "KI67R", "K167R" ]

[ 753, 1044 ]

2

[]

0

[]

0

[ "PUB00016366", "PUB00077073" ]

[ "15112237", "8227122" ]

[ "Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.", "The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins." ]

[ 2004, 1993 ]

2

[]

0

null

[ "Bilateria" ]

[ 1044 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 1, 3 ]

4

true

Repeat

KI67R

9

IPR012569

12,569

Internalin, Ig-like inter-repeat region

Inl_IR

Domain

1,615

false

These are small, all β-strand domains, structurally described for the protein Internalin (InlA) and related proteins InlB, InlC, InlH from the pathogenic bacterium Listeria monocytogenes, in which it has been described as Ig-like inter-repeat (IR) region. Their function appears to be mainly structural: they are fused t...

[]

0

[ "PFAM" ]

[ "PF08191" ]

[ "LRR_adjacent" ]

[ 1615 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-8875360", "R-HSA-8876493" ]

[ "REACTOME:R-HSA-8875360", "REACTOME:R-HSA-8876493" ]

2

[ "1h6t", "1h6u", "1m9s", "1o6s", "1o6t", "1o6v", "1xeu", "2omt", "2omu", "2omv", "2omw", "2omx", "2omy", "2omz", "2uzx", "2uzy", "2wqu", "2wqv", "2wqw", "2wqx", "2y5q", "4aw4", "4cc4", "4cil", "6dbg", "6gcu", "7nms", "7pv8", "7pv9", "8h62", "8h63", "8h64"...

33

[ "PUB00001625", "PUB00001898", "PUB00007147", "PUB00007148", "PUB00016485", "PUB00016543", "PUB00016557", "PUB00017058", "PUB00094376", "PUB00095652", "PUB00106890" ]

[ "1657640", "2176636", "11751054", "11967365", "12526809", "11575932", "15003459", "14747988", "21606681", "24332715", "35234145" ]

[ "A leucine-rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a beta-sheet structure.", "slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.", "The leucine-rich repeat as a protein reco...

[ 1991, 1990, 2001, 2002, 2002, 2001, 2004, 2004, 2011, 2014, 2022 ]

11

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group" ]

[ 1604, 7, 4 ]

3

[]

0

true

Domain

Internalin, Ig-like inter-repeat region

Inl_IR

4

IPR012570

12,570

Leucine operon leader peptide

Leu_leader

Family

468

false

This family consists of the leucine operon leader peptide. The leucine operon is involved in the control of the biosynthesis of leucine. Four adjacent leucine codons within the leucine leader RNA are critically important in transcription attenuation-mediated control of leucine operon expression in bacteria. The leader ...

[ "GO:0009098" ]

[ "L-leucine biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08054" ]

[ "Leu_leader" ]

[ 468 ]

1

[]

0

[]

0

[ "PUB00016465" ]

[ "3922957" ]

[ "Mutations that convert the four leucine codons of the Salmonella typhimurium leu leader to four threonine codons." ]

[ 1985 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 468 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Leucine operon leader peptide

Leu_leader

2

IPR012571

12,571

Mitochondrial distribution and morphology protein family 31/32, fungi

Mdm31/Mdm32

Family

1,973

false

Proteins in this family are yeast mitochondrial inner membrane proteins Mdm31 and Mdm32. They are required for the maintenance of mitochondrial morphology, and the stability of mitochondrial DNA [ ]. Mdm31 plays important roles in phospholipid biosynthesis in mitochondria [ ].

[ "GO:0000001", "GO:0007005", "GO:0005743" ]

[ "mitochondrion inheritance", "mitochondrion organization", "mitochondrial inner membrane" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08118", "PTHR31068" ]

[ "MDM31_MDM32", "" ]

[ 1972, 1967 ]

2

[]

0

[]

0

[ "PUB00016364", "PUB00077035" ]

[ "15631992", "22403410" ]

[ "Mdm31 and Mdm32 are inner membrane proteins required for maintenance of mitochondrial shape and stability of mitochondrial DNA nucleoids in yeast.", "Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking." ]

[ 2005, 2012 ]

2

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 1970, 3 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 1 ]

3

true

Family

Mitochondrial distribution and morphology protein family 31/32, fungi

Mdm31/Mdm32

8

IPR012572

12,572

Mad3/Bub1 homology region 2

Mad3/Bub1_II

Domain

1,323

false

This domain is found in checkpoint proteins which are involved in cell division. This region has been shown to be necessary and sufficient for the binding of Mad3 to Bub3 in Saccharomyces cerevisiae. This domain is present in Bub1 which also binds Bub3 [ ].

[]

0

[ "PFAM" ]

[ "PF08171" ]

[ "Mad3_BUB1_II" ]

[ 1323 ]

1

[ "REACTOME" ]

[ "R-SCE-141430" ]

[ "REACTOME:R-SCE-141430" ]

1

[ "2i3s", "2i3t", "4bl0" ]

3

[ "PUB00017177" ]

[ "10704439" ]

[ "MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p." ]

[ 2000 ]

1

[]

0

null

[ "Fungi" ]

[ 1323 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 2 ]

2

true

Domain

Mad3/Bub1 homology region 2

Mad3/Bub1_II

4

IPR012573

12,573

Meleagrin/Cygnin

Family

344

false

This family consists of meleagrin and cygnin basic peptides that are isolated from turkey and black swan respectively. Both peptides are low in molecular weight and contain three disulphide bonds with high concentrations of aromatic residues. These peptides show similarity to transferrins and probably play some vital r...

[]

0

[ "PFAM" ]

[ "PF08189" ]

[ "Meleagrin" ]

[ 344 ]

1

[]

0

[ "2mjk" ]

1

[ "PUB00016588" ]

[ "2760022" ]

[ "Covalent structure of a low-molecular-mass protein, meleagrin, present in a turkey (Meleagris gallopavo) ovomucoid preparation." ]

[ 1989 ]

1

[]

0

null

[ "Aves" ]

[ 344 ]

1

[]

0

true

Family

Meleagrin/Cygnin

2

IPR012574

12,574

ATP synthase subunit ATP5MJ, mitochondrial

ATP5MJ

Family

671

false

ATP5MJ (also known as ATP5MPL and MLQ) is a hydrophobic mitochondrial protein and a regulator of the mitochondrial ATP synthesis [ ].

[ "GO:0005739" ]

[ "mitochondrion" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF08039", "PTHR15233" ]

[ "Mit_proteolip", "" ]

[ 671, 653 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-163210", "R-BTA-8949613", "R-HSA-163210", "R-HSA-8949613", "R-MMU-163210", "R-MMU-8949613" ]

[ "REACTOME:R-BTA-163210", "REACTOME:R-BTA-8949613", "REACTOME:R-HSA-163210", "REACTOME:R-HSA-8949613", "REACTOME:R-MMU-163210", "REACTOME:R-MMU-8949613" ]

6

[ "6tt7", "6za9", "6zbb", "6ziq", "6zit", "6ziu", "6zmr", "6zna", "6zpo", "6zqm", "6zqn", "7ajb", "7ajc", "7ajd", "7aje", "7ajf", "7ajg", "7ajh", "7aji", "7ajj", "8h9f", "8h9j", "8h9m", "8h9q", "8h9s", "8h9t", "8h9u", "8h9v", "8khf", "8ki3" ]

30

[ "PUB00092778" ]

[ "24330338" ]

[ "Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ)." ]

[ 2014 ]

1

[]

0

null

[ "Vertebrata" ]

[ 671 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 2, 3 ]

4

true

Family

ATP synthase subunit ATP5MJ, mitochondrial

ATP5MJ

4

IPR012575

12,575

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, NDUB1

NDUB1

Family

987

false

This family consists of the subunit 1 (NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUB1 or NDUFB1, also known as MNLL subunit) of NADH:ubiquinone oxidoreductase complex [ , ]. This is an accessory subunit of complex I, not involved in catalysis [ , ].

[ "GO:0005739" ]

[ "mitochondrion" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF08040", "PTHR15222" ]

[ "NADH_oxidored", "" ]

[ 987, 861 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198", "R-RNO-611105", "R-RNO-6799198" ]

[ "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198", "REACTOME:R-RNO-611105", "REACTOME:R-RNO-6799198" ]

6

[ "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zka", "6zkb", "6zkc", "6zkd", "6zke", "6zkf", "6zkg"...

208

[ "PUB00005074", "PUB00016460", "PUB00016555", "PUB00043561", "PUB00045437", "PUB00086570", "PUB00097152" ]

[ "1470679", "12644575", "15581635", "10940377", "18394423", "27626371", "31485716" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "Analysis of the subunit composition of complex I from bovine heart mitochondria.", "Functional properties of the alternative NADH:ubiquinone oxidoreductase from E. coli through comparative 3-D modelling.", "The respiratory complex I of ...

[ 1992, 2003, 2004, 2000, 2008, 2016, 2020 ]

7

[]

0

null

[ "Bilateria" ]

[ 987 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 1, 2 ]

5

true

Family

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1, NDUB1

NDUB1

6

IPR012576

12,576

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

NDUFB3

Family

3,274

false

This family represents an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain [ ].

[ "GO:0022900", "GO:0005739" ]

[ "electron transport chain", "mitochondrion" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08122", "PTHR15082" ]

[ "NDUF_B12", "" ]

[ 3239, 2933 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

6

[ "5gup", "5lnk", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6rfq", "6rfr", "6rfs", "6y79", "6yj4", "6zka", "6zkb", "6zkc", "6zkd", "6zke"...

238

[ "PUB00005074", "PUB00043561", "PUB00045437", "PUB00060842" ]

[ "1470679", "10940377", "18394423", "12611891" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I).", "The subunit composition o...

[ 1992, 2000, 2008, 2003 ]

4

[]

0

null

[ "Eukaryota" ]

[ 3274 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 1, 1, 2, 2, 1, 3, 5, 14 ]

10

true

Family

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

NDUFB3

8

IPR012577

12,577

NIPSNAP

Domain

15,768

false

Proteins containing this domain include many hypothetical proteins. It also includes members of the NIPSNAP family, which have putative roles in vesicular transport [ ]. This domain is often found in duplicate.

[]

0

[ "PFAM" ]

[ "PF07978" ]

[ "NIPSNAP" ]

[ 15768 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-9013407", "R-DDI-9013407", "R-DME-9013407", "R-HSA-9013407", "R-HSA-9013409", "R-MMU-9013407" ]

[ "REACTOME:R-CEL-9013407", "REACTOME:R-DDI-9013407", "REACTOME:R-DME-9013407", "REACTOME:R-HSA-9013407", "REACTOME:R-HSA-9013409", "REACTOME:R-MMU-9013407" ]

6

[ "1vqs", "1vqy", "2ap6", "5ixu", "5k9f", "5kak" ]

6

[ "PUB00016515" ]

[ "9661659" ]

[ "Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Sym plasmid", "unclassified sequences" ]

[ 9091, 6519, 2, 1, 155 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 5, 2, 10, 11, 1, 18 ]

7

true

Domain

NIPSNAP

7

IPR012578

12,578

Nuclear pore complex component

Nucl_pore_cmplx

Family

1,151

false

Proteins containing this domain are components of the nuclear pore complex [ ]. One member of this domain is Nucleoporin POM34 ( ) which is thought to have a role in anchoring peripheral Nups into the pore and mediating pore formation [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08058", "PTHR28003" ]

[ "NPCC", "" ]

[ 1141, 1093 ]

2

[]

0

[ "8t9l" ]

1

[ "PUB00016425" ]

[ "12791264" ]

[ "Peering through the pore: nuclear pore complex structure, assembly, and function." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1151 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Nuclear pore complex component

Nucl_pore_cmplx

9

IPR012579

12,579

U3 small nucleolar RNA-associated protein NOL7, C-terminal

NOL7_C

Domain

679

false

This entry represents the C-terminal domain of human U3 small nucleolar RNA-associated protein NOL7 (also known as Nucleolar protein 7) and similar proteins from vertebrates. NOL7 is part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit [ ] and has been reported to act as...

[ "GO:0005634" ]

[ "nucleus" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF08157" ]

[ "NUC129" ]

[ 679 ]

1

[]

0

[ "7mq8", "7mq9", "7mqa" ]

3

[ "PUB00078789", "PUB00151110", "PUB00153093" ]

[ "22123719", "34516797", "37246770" ]

[ "Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.", "Nucleolar maturation of the human small subunit processome.", "Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing." ]

[ 2012, 2021, 2023 ]

3

[]

0

null

[ "Eumetazoa" ]

[ 679 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 3, 3 ]

4

true

Domain

U3 small nucleolar RNA-associated protein NOL7, C-terminal

NOL7_C

5