LiteFold/InterPro · Datasets at Hugging Face

IPR012812

12,812

Mannosyl-3-phosphoglycerate synthase

Osmo_MPG_synth

Family

348

false

This family consists of examples of mannosyl-3-phosphoglycerate synthase (MPGS), which together with mannosyl-3-phosphoglycerate phosphatase (MPGP), comprises a two-step pathway for mannosylglycerate biosynthesis. Mannosylglycerate is a compatible solute that tends to be restricted to extreme thermophiles of archaea an...

[ "GO:0050504", "GO:0051479", "GO:0005737" ]

[ "mannosyl-3-phosphoglycerate synthase activity", "mannosylglycerate biosynthetic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "NCBIFAM" ]

[ "PF09488", "TIGR02460" ]

[ "Osmo_MPGsynth", "osmo_MPGsynth" ]

[ 348, 178 ]

2

[ "EC", "GP", "METACYC" ]

[ "2.4.1.217", "GenProp0281", "PWY-5656" ]

[ "EC:2.4.1.217", "GP:GenProp0281", "METACYC:PWY-5656" ]

3

[ "2wvk", "2wvl", "2wvm", "2zu7", "2zu8", "2zu9" ]

6

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes", "leotiomyceta" ]

[ 75, 91, 13, 169 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Mannosyl-3-phosphoglycerate synthase

Osmo_MPG_synth

9

IPR012814

12,814

Pyranose 2-oxidase

P2OX

Family

253

false

Fungal pyranose 2-oxidase (P2OX) catalyses the oxidation of various aldopyranoses and disaccharides on carbon-2 to the corresponding 2-keto sugars concomitant with the reduction of O2 to H2O2. Peroxide production is believed to be important to the wood rot fungi in which this enzyme is found for lignin degradation [ , ...

[ "GO:0050233", "GO:0050660" ]

[ "pyranose oxidase activity", "flavin adenine dinucleotide binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR02462" ]

[ "pyranose_ox" ]

[ 253 ]

1

[ "EC" ]

[ "1.1.3.10" ]

[ "EC:1.1.3.10" ]

1

[ "1tt0", "1tzl", "2f5v", "2f6c", "2igk", "2igm", "2ign", "2igo", "3bg6", "3bg7", "3bly", "3fdy", "3k4b", "3k4c", "3k4j", "3k4k", "3k4l", "3k4m", "3k4n", "3lsh", "3lsi", "3lsk", "3lsm", "3pl8", "4mif", "4mig", "4mih", "4moe", "4mof", "4mog", "4moh", "4moi"...

41

[ "PUB00077038", "PUB00077039" ]

[ "16349330", "8661938" ]

[ "Pyranose Oxidase, a Major Source of H(2)O(2) during Wood Degradation by Phanerochaete chrysosporium, Trametes versicolor, and Oudemansiella mucida.", "Only C-2 specific glucose oxidase activity is expressed in ligninolytic cultures of the white rot fungus Phanerochaete chrysosporium." ]

[ 1994, 1996 ]

2

[ "IPR051473" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta" ]

[ 20, 233 ]

2

[]

0

true

Family

Pyranose 2-oxidase

P2OX

8

IPR012815

12,815

Mannosyl-3-phosphoglycerate phosphatase

MPG_Pase

Family

446

false

Members of this family are mannosyl-3-phosphoglycerate phosphatase ( ). It acts sequentially after mannosyl-3-phosphoglycerate synthase ( ) in a two-step pathway of biosynthesis of the compatible solute mannosylglycerate, a typical osmolyte of thermophiles [ ].

[ "GO:0050531", "GO:0051479", "GO:0005737" ]

[ "mannosyl-3-phosphoglycerate phosphatase activity", "mannosylglycerate biosynthetic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP" ]

[ "MF_00617" ]

[ "MPGP_rel" ]

[ 446 ]

1

[ "EC", "METACYC" ]

[ "3.1.3.70", "PWY-5656" ]

[ "EC:3.1.3.70", "METACYC:PWY-5656" ]

2

[ "1wzc", "1xvi", "2zos" ]

3

[ "PUB00017808" ]

[ "11562374" ]

[ "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes." ]

[ 2001 ]

1

[ "IPR006381" ]

[]

1

0

1

[ "Archaea", "Enterobacteriaceae" ]

[ 14, 432 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Mannosyl-3-phosphoglycerate phosphatase

MPG_Pase

2

IPR012817

12,817

Chlorocatechol 1,2-dioxygenase

Chlorcchol_dOase

Family

107

false

Members of this protein family are chlorocatechol 1,2-dioxygenases. This enzyme is a homodimeric intradiol dioxygenase that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part of the modified ortho-cleavage pathway which is...

[ "GO:0005506" ]

[ "iron ion binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "CDD" ]

[ "TIGR02465", "cd03462" ]

[ "chlorocat_1_2", "1_2-CCD" ]

[ 85, 104 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "1.13.11.-", "PWY-181", "PWY-5163", "PWY-5642", "PWY-6068", "PWY-6069", "PWY-6084", "PWY-6087", "PWY-6089", "PWY-6093", "PWY-6094", "PWY-6102", "PWY-6107", "PWY-6178", "PWY-6190", "PWY-6193", "PWY-6336", "PWY-6339", "PWY-6667", "PWY-7006", "PWY-7009", "PWY-7010", "PWY-701...

[ "EC:1.13.11.-", "METACYC:PWY-181", "METACYC:PWY-5163", "METACYC:PWY-5642", "METACYC:PWY-6068", "METACYC:PWY-6069", "METACYC:PWY-6084", "METACYC:PWY-6087", "METACYC:PWY-6089", "METACYC:PWY-6093", "METACYC:PWY-6094", "METACYC:PWY-6102", "METACYC:PWY-6107", "METACYC:PWY-6178", "METACYC:PWY-...

38

[ "1s9a", "2boy", "3hgi", "3hhx", "3hhy", "3hj8", "3hjq", "3hjs", "3hkp", "3i4v", "3i4y", "3i51", "3o32", "3o5u", "3o6j", "3o6r", "3th1" ]

17

[ "PUB00015256", "PUB00080933" ]

[ "10730195", "16030237" ]

[ "Catechol dioxygenases.", "Amino acids in positions 48, 52, and 73 differentiate the substrate specificities of the highly homologous chlorocatechol 1,2-dioxygenases CbnA and TcbC." ]

[ 1999, 2005 ]

2

[]

0

null

[ "Bacteria" ]

[ 107 ]

1

[]

0

true

Family

Chlorocatechol 1,2-dioxygenase

Chlorcchol_dOase

6

IPR012818

12,818

Precorrin-6Y methyltransferase

CbiE

Domain

12,283

false

Cobalamin (vitamin B12) is a structurally complex cofactor, consisting of a modified tetrapyrrole with a centrally chelated cobalt. Cobalamin is usually found in one of two biologically active forms: methylcobalamin and adocobalamin. Most prokaryotes, as well as animals, have cobalamin-dependent enzymes, whereas plants...

[ "GO:0008276", "GO:0009236" ]

[ "protein methyltransferase activity", "cobalamin biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR02467", "cd11644" ]

[ "CbiE", "Precorrin-6Y-MT" ]

[ 11955, 12234 ]

2

[ "EC", "GP" ]

[ "2.1.1", "GenProp0275" ]

[ "EC:2.1.1", "GP:GenProp0275" ]

2

[ "2bb3" ]

1

[ "PUB00009744", "PUB00014672", "PUB00014680", "PUB00014681", "PUB00015657", "PUB00035308", "PUB00035309", "PUB00035310", "PUB00070131" ]

[ "11215515", "11153269", "12429089", "1732195", "12869542", "17163662", "16042605", "12055304", "23922391" ]

[ "Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.", "Multiple biosynthetic pathways for vitamin B12: variations on a central theme.", "The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase.", "Biosynthesis of vitamin B12 in Pseudomonas...

[ 2000, 2001, 2002, 1992, 2003, 2006, 2005, 2002, 2013 ]

9

[ "IPR000878" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 610, 11570, 11, 92 ]

4

[]

0

true

Domain

Precorrin-6Y methyltransferase

CbiE

7

IPR012820

12,820

Sucrose synthase, plant/cyanobacteria

Sucrose_synthase_pln/cyn

Family

5,641

false

This entry represents sucrose synthase an enzyme that despite its name, generally uses rather produces sucrose. Sucrose plus UDP (or ADP) becomes D-fructose plus UDP-glucose (or ADP-glucose), which is then available for cell wall (or starch) biosynthesis. The enzyme is homologous to sucrose phosphate synthase, which ca...

[ "GO:0016157", "GO:0005985" ]

[ "sucrose synthase activity", "sucrose metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER", "NCBIFAM" ]

[ "PTHR45839", "TIGR02470" ]

[ "", "sucr_synth" ]

[ 5640, 4092 ]

2

[ "EC", "GP", "METACYC" ]

[ "2.4.1.13", "GenProp1639", "PWY-3801" ]

[ "EC:2.4.1.13", "GP:GenProp1639", "METACYC:PWY-3801" ]

3

[ "3s27", "3s28", "3s29", "4rbn" ]

4

[ "PUB00017811" ]

[ "11950997" ]

[ "Evolution of sucrose synthesis." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 393, 5238, 10 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 40, 21, 113 ]

3

true

Family

Sucrose synthase, plant/cyanobacteria

Sucrose_synthase_pln/cyn

4

IPR012821

12,821

Sucrose phosphate synthase, sucrose phosphatase-like domain

Sucrose_P_synth_Pase-like_dom

Domain

486

false

Sucrose phosphate synthase (SPS) and sucrose phosphate phosphatase (SPP) are the last two enzymes of sucrose biosynthesis. In cyanobacteria and plants, the C-terminal region of most or all versions of SPS has a domain homologous to the known SPP. This domain may serve a binding or regulatory rather than catalytic funct...

[]

0

[ "NCBIFAM" ]

[ "TIGR02471" ]

[ "sucr_syn_bact_C" ]

[ 486 ]

1

[]

0

[]

0

[]

0

[ "IPR006380" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 472, 14 ]

2

[]

0

true

Domain

Sucrose phosphate synthase, sucrose phosphatase-like domain

Sucrose_P_synth_Pase-like_dom

7

IPR012822

12,822

Sucrose-phosphate synthase, glycosyltransferase domain

SucroseP_synth_GlycoTrfase_dom

Domain

474

false

This family consists of the N-terminal regions, or in some cases the entirety, of bacterial proteins closely related to plant sucrose-phosphate synthases (SPS). The C-terminal domain ( ), found with most members of this family, resembles both bona fide plant sucrose-phosphate phosphatases (SPP) and the SPP-like domain ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02472" ]

[ "sucr_P_syn_N" ]

[ 474 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 463, 11 ]

2

[]

0

true

Domain

Sucrose-phosphate synthase, glycosyltransferase domain

SucroseP_synth_GlycoTrfase_dom

4

IPR012823

12,823

Flagellar export FliJ

Flagell_FliJ

Family

10,192

false

The bacterial flagellum consists of three major parts: the basal body (including the rod), the hook, and the filament. Outer components of the flagellum are transported to the assembly site by a specialised type III export apparatus, which is related to the type III secretion system (T3SS). FliJ is a soluble regulatory...

[ "GO:0071973", "GO:0009288" ]

[ "bacterial-type flagellum-dependent cell motility", "bacterial-type flagellum" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "NCBIFAM" ]

[ "PF02050", "TIGR02473" ]

[ "FliJ", "flagell_FliJ" ]

[ 10129, 8136 ]

2

[ "GP", "GP" ]

[ "GenProp0879", "GenProp0885" ]

[ "GP:GenProp0879", "GP:GenProp0885" ]

2

[ "3ajw", "8ftw", "8ftx" ]

3

[ "PUB00076721" ]

[ "25068520" ]

[ "Soluble components of the flagellar export apparatus, FliI, FliJ, and FliH, do not deliver flagellin, the major filament protein, from the cytosol to the export gate." ]

[ 2014 ]

1

[]

[ "IPR018006" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10049, 17, 126 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar export FliJ

Flagell_FliJ

3

IPR012825

12,825

5,6-dimethylbenzimidazole synthase BluB

BluB

Family

6,980

false

A previously published hypothesis that BluB, involved in cobalamin biosynthesis [ , ], is cob(II)yrinic acid a,c-diamide reductase ( ) has now been contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis [ , ]. The BluB protein is related to the nitroreductase family.

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR02476", "cd02145" ]

[ "BluB", "BluB" ]

[ 6980, 2449 ]

2

[ "EC", "METACYC" ]

[ "1.13.11.79", "PWY-5523" ]

[ "EC:1.13.11.79", "METACYC:PWY-5523" ]

2

[ "2isj", "2isk", "2isl" ]

3

[ "PUB00002275", "PUB00015657", "PUB00047736", "PUB00056791" ]

[ "7635831", "12869542", "17377583", "17301238" ]

[ "Identification and sequence analysis of genes involved in late steps in cobalamin (vitamin B12) synthesis in Rhodobacter capsulatus.", "Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes.", "BluB cannibalizes flavin to form the lower ligand of vitamin B12.", "Single-enzyme conve...

[ 1995, 2003, 2007, 2007 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 183, 6713, 20, 64 ]

4

[]

0

true

Family

5,6-dimethylbenzimidazole synthase BluB

BluB

1

IPR012826

12,826

Flagellar motor switch FliN

FliN

Family

11,930

false

The flagellar motor switch in Escherichia coli and Salmonella typhimurium regulates the direction of flagellar rotation and hence controls swimming behaviour. The switch is a complex apparatus that responds to signals transduced by the chemotaxis sensory signalling system during chemotactic behaviour [ ]. The switch co...

[ "GO:0006935", "GO:0071973", "GO:0009288", "GO:0016020" ]

[ "chemotaxis", "bacterial-type flagellum-dependent cell motility", "bacterial-type flagellum", "membrane" ]

[ "biological_process", "biological_process", "cellular_component", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR02480" ]

[ "fliN" ]

[ 11930 ]

1

[ "GP", "GP", "GP" ]

[ "GenProp0883", "GenProp1183", "GenProp1194" ]

[ "GP:GenProp0883", "GP:GenProp1183", "GP:GenProp1194" ]

3

[ "1o6a", "1yab", "4yxb", "4yxc", "5xrw", "8umd", "8umx", "8uox", "8upl", "8vib", "8vid", "8vkq", "8vkr", "8wiw", "8wo5", "8woe", "8xp0", "8xp1", "8yjt", "9n49", "9n4z" ]

21

[ "PUB00001834", "PUB00002083", "PUB00002290", "PUB00004790" ]

[ "8224881", "2656645", "8631704", "1631122" ]

[ "Gene sequence, overproduction, purification and determination of the wild-type level of the Escherichia coli flagellar switch protein FliG.", "Flagellar switch of Salmonella typhimurium: gene sequences and deduced protein sequences.", "A mutational analysis of the interaction between FliG and FliM, two compone...

[ 1993, 1989, 1996, 1992 ]

4

[ "IPR001172" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 11761, 15, 154 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar motor switch FliN

FliN

1

IPR012827

12,827

Hemerythrin, metal-binding domain

Hemerythrin_metal-bd

Domain

8,727

false

The hemerythrin family is composed of hemerythrin proteins found in invertebrates, and a broader collection of bacterial and archaeal homologues. Hemerythrin is an oxygen-binding protein found in the vascular system and coelomic fluid, or in muscles (myohemerythrin) in invertebrates [ ]. Many of the homologous proteins...

[ "GO:0046872" ]

[ "metal ion binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "CDD" ]

[ "TIGR02481", "cd12107" ]

[ "hemeryth_dom", "Hemerythrin" ]

[ 8420, 8687 ]

2

[]

0

[ "1a7d", "1a7e", "1hmd", "1hmo", "1i4y", "2avk", "2awc", "2awy", "2hmq", "2hmz", "2mhr", "3agt", "3agu", "3waq", "3whn", "4xpw", "4xpx", "4xpy", "4xq1" ]

19

[ "PUB00001429", "PUB00001615", "PUB00003224", "PUB00004613", "PUB00005066" ]

[ "1425663", "2065779", "3681996", "3856224", "2362933" ]

[ "Ovohemerythrin, a major 14-kDa yolk protein distinct from vitellogenin in leech.", "Primary structure of myohemerythrin from the annelid Nereis diversicolor.", "Structure of myohemerythrin in the azidomet state at 1.7/1.3 A resolution.", "Active site structures of deoxyhemerythrin and oxyhemerythrin.", "Th...

[ 1992, 1991, 1987, 1985, 1990 ]

5

[ "IPR012312" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 94, 7926, 512, 195 ]

4

[]

0

true

Domain

Hemerythrin, metal-binding domain

Hemerythrin_metal-bd

7

IPR012828

12,828

ATP-dependent 6-phosphofructokinase, prokaryotic

PFKA_ATP_prok

Family

9,928

false

6-phosphofructokinase ( ), a key regulatory enzyme in glycolysis, catalyses the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This entry contains bacterial ATP-dependent 6-phosphofructokinases, which lack a β-hairpin loop pres...

[ "GO:0003872", "GO:0005524", "GO:0006002", "GO:0006096" ]

[ "6-phosphofructokinase activity", "ATP binding", "fructose 6-phosphate metabolic process", "glycolytic process" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00339", "TIGR02482", "cd00763" ]

[ "Phosphofructokinase_I_B1", "PFKA_ATP", "Bacterial_PFK" ]

[ 9891, 9741, 2741 ]

3

[ "EC", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.11", "GenProp0694", "GenProp1306", "GenProp1407", "GenProp1599", "GenProp1705", "PWY-1042", "PWY-1861", "PWY-5484", "PWY-7385" ]

[ "EC:2.7.1.11", "GP:GenProp0694", "GP:GenProp1306", "GP:GenProp1407", "GP:GenProp1599", "GP:GenProp1705", "METACYC:PWY-1042", "METACYC:PWY-1861", "METACYC:PWY-5484", "METACYC:PWY-7385" ]

10

[ "1mto", "1pfk", "1zxx", "2pfk", "3pfk", "3u39", "4a3s", "4i36", "4i4i", "4i7e", "4pfk", "5xoe", "5xz6", "5xz7", "5xz8", "5xz9", "5xza", "6pfk" ]

18

[]

0

[ "IPR012003" ]

[]

1

0

1

[ "Bacteria", "Methanomicrobia", "Opisthokonta", "Siphoviridae sp. ctx254", "metagenomes" ]

[ 9829, 33, 12, 1, 53 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

ATP-dependent 6-phosphofructokinase, prokaryotic

PFKA_ATP_prok

6

IPR012829

12,829

Phosphofructokinase, mixed-substrate PFK group III

Phosphofructokinase_III

Family

8,419

false

This entry includes pyrophosphate--fructose 6-phosphate 1-phosphotransferase from Amycolatopsis methanolica [ ] and ATP-dependent 6-phosphofructokinase 2 from Streptomyces coelicolor [ ]. They catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis.

[ "GO:0047334", "GO:0006096" ]

[ "diphosphate-fructose-6-phosphate 1-phosphotransferase activity", "glycolytic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01976", "TIGR02483" ]

[ "Phosphofructokinase_III", "PFK_mixed" ]

[ 8409, 6027 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.11", "PWY-1042", "PWY-1861", "PWY-5484", "PWY-7385" ]

[ "EC:2.7.1.11", "METACYC:PWY-1042", "METACYC:PWY-1861", "METACYC:PWY-5484", "METACYC:PWY-7385" ]

5

[]

0

[ "PUB00014446", "PUB00017820" ]

[ "11717283", "9055413" ]

[ "Different physiological roles of ATP- and PP(i)-dependent phosphofructokinase isoenzymes in the methylotrophic actinomycete Amycolatopsis methanolica.", "Identification of ATP-dependent phosphofructokinase as a regulatory step in the glycolytic pathway of the actinomycete Streptomyces coelicolor A3(2)." ]

[ 2001, 1997 ]

2

[ "IPR012003" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 32, 8181, 10, 196 ]

4

[]

0

true

Family

Phosphofructokinase, mixed-substrate PFK group III

Phosphofructokinase_III

6

IPR012830

12,830

Citrate utilization protein B

CitB

Family

2,171

false

This entry identifies proteins that are decribed as citrate utilization protein B, restricted to the proteobacteria. CitB [ ] has been identified in Salmonella and Escherichia coli as the signal transduction component of a two-component system for citrate in which CitA acts as a citrate transporter. This domain is also...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF27541", "TIGR02484" ]

[ "CitB", "CitB" ]

[ 2171, 1961 ]

2

[]

0

[]

0

[ "PUB00016702", "PUB00016912", "PUB00106878" ]

[ "15525640", "1718953", "30222098" ]

[ "Identification and characterization of a novel vitamin B12 (cobalamin) biosynthetic enzyme (CobZ) from Rhodobacter capsulatus, containing flavin, heme, and Fe-S cofactors.", "Cloning and nucleotide sequence of the gene (citA) encoding a citrate carrier from Salmonella typhimurium.", "The monofunctional cobalam...

[ 2005, 1991, 2018 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 16, 2140, 2, 13 ]

4

[]

0

true

Family

Citrate utilization protein B

CitB

1

IPR012831

12,831

Precorrin 3B synthase CobZ

CobZ

Family

1,884

false

Cobalamin (vitamin B12) is a structurally complex cofactor, consisting of a modified tetrapyrrole with a centrally chelated cobalt. Cobalamin is usually found in one of two biologically active forms: methylcobalamin and adocobalamin. Most prokaryotes, as well as animals, have cobalamin-dependent enzymes, whereas plants...

[]

0

[ "NCBIFAM" ]

[ "TIGR02485" ]

[ "CobZ_N-term" ]

[ 1884 ]

1

[]

0

[]

0

[ "PUB00009744", "PUB00014672", "PUB00015657", "PUB00016702", "PUB00035308", "PUB00035309", "PUB00035310", "PUB00070131", "PUB00106694", "PUB00106878" ]

[ "11215515", "11153269", "12869542", "15525640", "17163662", "16042605", "12055304", "23922391", "17630784", "30222098" ]

[ "Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.", "Multiple biosynthetic pathways for vitamin B12: variations on a central theme.", "Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes.", "Identification and characterization of a novel vitamin B12 (cobalamin) bios...

[ 2000, 2001, 2003, 2005, 2006, 2005, 2002, 2013, 2007, 2018 ]

10

[ "IPR050315" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 7, 1871, 6 ]

3

[]

0

true

Family

Precorrin 3B synthase CobZ

CobZ

2

IPR012832

12,832

Reductive dehalogenase

RDH

Domain

1,062

false

This entry represents the C-terminal domain in corrin and 8-iron Fe-S cluster-containing reductive dehalogenase [ ] found primarily in halorespiring microorganisms such as Dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterised enzyme i...

[]

0

[ "NCBIFAM" ]

[ "TIGR02486" ]

[ "RDH" ]

[ 1062 ]

1

[ "EC" ]

[ "1.21.99.5" ]

[ "EC:1.21.99.5" ]

1

[ "4uqu", "4ur0", "4ur1", "4ur2", "4ur3", "5m2g", "5m8u", "5m8w", "5m8x", "5m8y", "5m8z", "5m90", "5m91", "5m92", "5ma0", "5ma1", "5ma2", "5maa", "5obi", "5obp", "8q4h" ]

21

[ "PUB00016698", "PUB00016713" ]

[ "11097881", "9224702" ]

[ "Trichloroethene reductive dehalogenase from Dehalococcoides ethenogenes: sequence of tceA and substrate range characterization.", "Redox chemistry of cobalamin and iron-sulfur cofactors in the tetrachloroethene reductase of Dehalobacter restrictus." ]

[ 2000, 1997 ]

2

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 5, 1008, 49 ]

3

[]

0

true

Domain

Reductive dehalogenase

RDH

6

IPR012833

12,833

Ribonucleoside-triphosphate reductase, anaerobic

NrdD

Family

15,065

false

This entry represents anaerobic, class III ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centred radical [ ], a C-terminal zinc binding site [ ], and a set of conserved active site cysteines and asparagines [ ]. This enzyme requires an activating component, NrdG, a radical-SAM domain containi...

[ "GO:0008998", "GO:0016491", "GO:0006260" ]

[ "ribonucleoside-triphosphate reductase (thioredoxin) activity", "oxidoreductase activity", "DNA replication" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "NCBIFAM", "NCBIFAM", "CDD" ]

[ "PF13597", "TIGR02487", "TIGR02827", "cd01675" ]

[ "NRDD", "NrdD", "RNR_anaer_Bdell", "RNR_III" ]

[ 15065, 11333, 534, 8977 ]

4

[ "EC", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC" ]

[ "1.1.98.6", "GenProp0291", "GenProp1343", "GenProp1446", "GenProp1484", "GenProp1621", "PWY-7187", "PWY-7220", "PWY-7222" ]

[ "EC:1.1.98.6", "GP:GenProp0291", "GP:GenProp1343", "GP:GenProp1446", "GP:GenProp1484", "GP:GenProp1621", "METACYC:PWY-7187", "METACYC:PWY-7220", "METACYC:PWY-7222" ]

9

[ "1h78", "1h79", "1h7a", "1h7b", "1hk8", "4coi", "4coj", "4col", "4com", "4con", "4u3e", "8p23", "8p27", "8p28", "8p2c", "8p2d", "8p2s", "8p39" ]

18

[ "PUB00016693", "PUB00016704", "PUB00016706", "PUB00033790", "PUB00060768" ]

[ "11526118", "10066165", "12655046", "10574800", "15158709" ]

[ "Two active site asparagines are essential for the reaction mechanism of the class III anaerobic ribonucleotide reductase from bacteriophage T4.", "A glycyl radical site in the crystal structure of a class III ribonucleotide reductase.", "A metal-binding site in the catalytic subunit of anaerobic ribonucleotide...

[ 2001, 1999, 2003, 1999, 2004 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 553, 12884, 198, 1041, 389 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ribonucleoside-triphosphate reductase, anaerobic

NrdD

7

IPR012834

12,834

Flagellar basal-body rod FlgG

FlgG_G_neg

Family

9,799

false

This family consists of the FlgG protein of the flagellar apparatus in bacteria. The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod [ ]. The rod consists of about 26 subunits of flgG in the distal portion, and flgB, flgC and flgF are ...

[ "GO:0071973", "GO:0009426" ]

[ "bacterial-type flagellum-dependent cell motility", "bacterial-type flagellum basal body, distal rod" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR02488" ]

[ "flgG_G_neg" ]

[ 9799 ]

1

[ "GP" ]

[ "GenProp0880" ]

[ "GP:GenProp0880" ]

1

[ "5wrh", "6jzr", "7bin", "7cbm", "7cgo", "7e80", "7e82", "7nvg", "8wki", "8wkk", "8wl2", "8wlp", "8wlq", "8wlt", "8wo5", "8woe", "8z5u", "8z5w", "8z60" ]

19

[ "PUB00033604" ]

[ "15136044" ]

[ "In vitro characterization of FlgB, FlgC, FlgF, FlgG, and FliE, flagellar basal body proteins of Salmonella." ]

[ 2004 ]

1

[ "IPR020013" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9664, 24, 111 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar basal-body rod FlgG

FlgG_G_neg

2

IPR012835

12,835

Flagellar hook FlgE

FlgE_epsilon

Family

449

false

Members of this family are flagellar hook proteins, designated FlgE, as found in the epsilon subdivision of the proteobacteria (Helicobacter, Wolinella, and Campylobacter). These proteins differ significantly in architecture from proteins designated FlgE in other lineages; the N-terminal and C-terminal domains are homo...

[ "GO:0044781", "GO:0009288" ]

[ "bacterial-type flagellum organization", "bacterial-type flagellum" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR02489" ]

[ "flgE_epsilon" ]

[ 449 ]

1

[]

0

[ "5az4", "5jxl" ]

2

[ "PUB00017823" ]

[ "9658019" ]

[ "The central, surface-exposed region of the flagellar hook protein FlgE of Campylobacter jejuni shows hypervariability among strains." ]

[ 1998 ]

1

[ "IPR020013" ]

[]

1

0

1

[ "Campylobacterota", "hydrothermal vent metagenome" ]

[ 445, 4 ]

2

[]

0

true

Family

Flagellar hook FlgE

FlgE_epsilon

8

IPR012836

12,836

Flagellar basal-body rod FlgF

FlgF

Family

6,129

false

FlgF is a flagellar basal-body protein that along with FlgBCG composes the rod of bacterial flagellin [ ]. This entry contains proteins only from the proteobacteria, and not in the epsilon subdivision (where the architecture of the related FlgE protein differs substantially from other lineages).

[ "GO:0071973", "GO:0030694" ]

[ "bacterial-type flagellum-dependent cell motility", "bacterial-type flagellum basal body, rod" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR02490" ]

[ "flgF" ]

[ 6129 ]

1

[ "GP" ]

[ "GenProp0880" ]

[ "GP:GenProp0880" ]

1

[ "8z5s", "8z5u", "8z5w", "8z60" ]

4

[ "PUB00033604" ]

[ "15136044" ]

[ "In vitro characterization of FlgB, FlgC, FlgF, FlgG, and FliE, flagellar basal body proteins of Salmonella." ]

[ 2004 ]

1

[ "IPR020013" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6048, 4, 77 ]

3

[]

0

true

Family

Flagellar basal-body rod FlgF

FlgF

8

IPR012837

12,837

Ribonucleoside-triphosphate reductase activating, anaerobic

NrdG

Family

8,573

false

This enzyme [ ] is a member of the radical-SAM protein and utilises S-adenosyl methionine, an iron-sulphur cluster and a reductant (dihydroflavodoxin [ ]) to produce a glycine-centred radical in the class III (anaerobic) ribonucleotide triphosphate reductase (NrdD, ). The two components form an alpha-2/beta-2 heterodim...

[ "GO:0043365", "GO:0051539" ]

[ "[formate-C-acetyltransferase]-activating enzyme activity", "4 iron, 4 sulfur cluster binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF", "SFLD", "NCBIFAM" ]

[ "PIRSF000368", "SFLDF00299", "TIGR02491" ]

[ "NrdG", "anaerobic_ribonucleoside-triph", "NrdG" ]

[ 7501, 8422, 7430 ]

3

[ "EC", "GP", "METACYC" ]

[ "1.97.1.-", "GenProp0291", "PWY-6530" ]

[ "EC:1.97.1.-", "GP:GenProp0291", "METACYC:PWY-6530" ]

3

[]

0

[ "PUB00016703", "PUB00016711" ]

[ "11389585", "11297442" ]

[ "Activation of class III ribonucleotide reductase from E. coli. The electron transfer from the iron-sulfur center to S-adenosylmethionine.", "Activation of class III ribonucleotide reductase by flavodoxin: a protein radical-driven electron transfer to the iron-sulfur center." ]

[ 2001, 2001 ]

2

[ "IPR034457" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "unclassified sequences" ]

[ 7925, 7, 13, 571, 57 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ribonucleoside-triphosphate reductase activating, anaerobic

NrdG

2

IPR012838

12,838

Pyruvate formate-lyase 1 activating enzyme

PFL1_activating

Family

7,577

false

Pyruvate formate lyase-activating enzyme is a 28kDa monomeric protein which is involved in the anerobic glucose metabolism pathway. It is a member of the radical S-adenosylmethionine family of enzymes which initiate radical catalysis. It is necessary to activate pyruvate formate lyase (PFL), which catalyses the convers...

[ "GO:0043365" ]

[ "[formate-C-acetyltransferase]-activating enzyme activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR02493" ]

[ "PFLA" ]

[ 7577 ]

1

[ "EC", "GP" ]

[ "1.97.1.4", "GenProp0943" ]

[ "EC:1.97.1.4", "GP:GenProp0943" ]

2

[ "3c8f", "3cb8", "8fo0", "8fol", "8fsi" ]

5

[ "PUB00044952" ]

[ "15581584" ]

[ "Pyruvate formate-lyase activating enzyme: elucidation of a novel mechanism for glycyl radical formation." ]

[ 2005 ]

1

[ "IPR012839" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes", "unclassified Caudoviricetes" ]

[ 7504, 48, 23, 2 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Pyruvate formate-lyase 1 activating enzyme

PFL1_activating

9

IPR012839

12,839

Organic radical enzyme activase

Organic_radical_activase

Family

11,931

false

This subset of the radical-SAM domain includes a number of probable activating proteins acting on different enzymes all requiring an amino-acid-centred radical. The closest relatives to this family are the pyruvate-formate lyase activating enzyme (PflA, , ) and the anaerobic ribonucleotide reductase activating enzyme (...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF000371" ]

[ "PFL_act_enz" ]

[ 11931 ]

1

[ "EC" ]

[ "1.97.1" ]

[ "EC:1.97.1" ]

1

[ "3c8f", "3cb8", "8fo0", "8fol", "8fsi" ]

5

[ "PUB00016705", "PUB00016707", "PUB00016708", "PUB00090957" ]

[ "15153112", "12704244", "14735297", "28183913" ]

[ "Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity.", "Molecular characterization of the 1,3-propanediol (1,3-PD) operon of Clostridium butyricum.", "Genes involved in the anaerobic degradation of toluene in a denitr...

[ 2004, 2003, 2004, 2017 ]

4

[ "IPR034457" ]

[ "IPR012838", "IPR033974", "IPR040074" ]

1

3

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "unclassified Caudoviricetes" ]

[ 33, 11824, 3, 69, 2 ]

5

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Family

Organic radical enzyme activase

Organic_radical_activase

9

IPR012840

12,840

Anaerobic ribonucleoside-triphosphate reductase activating protein

NrdG2

Family

3,491

false

This enzyme is a member of the radical-SAM family. It is often gene clustered with the class III (anaerobic) ribonucleotide triphosphate reductase (NrdD, ) and presumably fulfils the identical function as NrdG [ , ], which utilises S-adenosyl methionine, an iron-sulphur cluster and a reductant (dihydroflavodoxin) to pr...

[]

0

[ "SFLD", "NCBIFAM" ]

[ "SFLDG01094", "TIGR02495" ]

[ "Uncharacterised_Radical_SAM_Su", "NrdG2" ]

[ 3452, 3431 ]

2

[ "GP" ]

[ "GenProp0291" ]

[ "GP:GenProp0291" ]

1

[]

0

[ "PUB00016703", "PUB00016711", "PUB00093688" ]

[ "11389585", "11297442", "26536144" ]

[ "Activation of class III ribonucleotide reductase from E. coli. The electron transfer from the iron-sulfur center to S-adenosylmethionine.", "Activation of class III ribonucleotide reductase by flavodoxin: a protein radical-driven electron transfer to the iron-sulfur center.", "A Ferredoxin Disulfide Reductase ...

[ 2001, 2001, 2015 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 339, 2896, 3, 159, 94 ]

5

[]

0

true

Family

Anaerobic ribonucleoside-triphosphate reductase activating protein

NrdG2

8

IPR012842

12,842

Type 3 secretion system stator protein SctL/SctL2

T3SS_SctL/SctL2

Family

2,131

false

This entry represents Type 3 secretion system stator proteins (also referred to HrpE-like proteins), which are the cytoplasmic components of bacterial type III secretion systems [ ]. Type 3 secretion systems (T3SSs) are used by many different Gram-negative pathogens and symbionts to inject bacterial effector proteins i...

[ "GO:0030254" ]

[ "protein secretion by the type III secretion system" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR02499" ]

[ "HrpE_YscL_not" ]

[ 2131 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[]

0

[ "PUB00034695", "PUB00097915", "PUB00097916", "PUB00097917" ]

[ "16672607", "20453832", "24722491", "30107569" ]

[ "Characterization of the Yersinia enterocolitica type III secretion ATPase YscN and its regulator, YscL.", "Deciphering the assembly of the Yersinia type III secretion injectisome.", "Functional characterization of the type III secretion ATPase SsaN encoded by Salmonella pathogenicity island 2.", "Bacterial t...

[ 2006, 2010, 2014, 2018 ]

4

[]

[ "IPR010586" ]

0

1

0

[ "Bacteria", "metagenomes" ]

[ 2124, 7 ]

2

[]

0

true

Family

Type 3 secretion system stator protein SctL/SctL2

T3SS_SctL/SctL2

6

IPR012843

12,843

YscD

Family

1,497

false

This family represents YscD from proteobacteria and similar putative type III secretion system bacteria such as HrpQ in Pseudomonas syringae, and EscD in enteropathogenic Escherichia coli. In the Chlamydiae, this entry describes the C-terminal 400 residues of a longer protein. YscD is a single-pass inner membrane prote...

[]

0

[ "NCBIFAM" ]

[ "TIGR02500" ]

[ "type_III_yscD" ]

[ 1497 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "4a0e", "4alz", "4d9v" ]

3

[ "PUB00020581", "PUB00076172" ]

[ "1860816", "23908767" ]

[ "Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica.", "In situ structural analysis of the Yersinia enterocolitica injectisome." ]

[ 1991, 2013 ]

2

[]

0

null

[ "Bacteria", "Bracon brevicornis", "metagenomes" ]

[ 1494, 1, 2 ]

3

[]

0

true

Family

YscD

8

IPR012844

12,844

Dihydroxyacetone kinase phosphotransferase subunit, N-terminal domain

DhaM_N

Domain

4,815

false

In Escherichia coli and many other bacteria, unlike the yeasts and a few bacteria such as Citrobacter freundii, the dihydroxyacetone kinase (also called glycerone kinase) transfers a phosphate from a phosphoprotein rather than from ATP. The dihydroxyacetone kinase of Escherichia coli consists of three subunits: DhaK, D...

[]

0

[ "NCBIFAM" ]

[ "TIGR02364" ]

[ "dha_pts" ]

[ 4815 ]

1

[ "EC", "GP", "GP" ]

[ "2.7.1.121", "GenProp1146", "GenProp1324" ]

[ "EC:2.7.1.121", "GP:GenProp1146", "GP:GenProp1324" ]

3

[ "3b48", "3cr3", "3ct6" ]

3

[ "PUB00033180" ]

[ "11350937" ]

[ "The dihydroxyacetone kinase of Escherichia coli utilizes a phosphoprotein instead of ATP as phosphoryl donor." ]

[ 2001 ]

1

[ "IPR004701" ]

[]

1

0

1

[ "Bacteria", "Ecdysozoa", "Methanobacteriota", "metagenomes" ]

[ 4702, 3, 100, 10 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Dihydroxyacetone kinase phosphotransferase subunit, N-terminal domain

DhaM_N

8

IPR012845

12,845

RNA polymerase sigma factor, FliA/WhiG

RNA_pol_sigma_FliA_WhiG

Family

10,988

false

Most members of this family are the flagellar operon sigma factor FliA, controlling transcription of bacterial flagellar genes by RNA polymerase. An exception is the sigma factor WhiG in the genus Streptomyces, involved in the production of sporulating aerial mycelium. The bacterial core RNA polymerase complex, which c...

[ "GO:0003677", "GO:0003899", "GO:0016987", "GO:0006352", "GO:0006355" ]

[ "DNA binding", "DNA-directed RNA polymerase activity", "sigma factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR02479" ]

[ "FliA_WhiG" ]

[ 10988 ]

1

[]

0

[ "1rp3", "1sc5", "6pfj", "6pfv", "6pmi", "6pmj" ]

6

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[]

[ "IPR028617" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10807, 12, 169 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RNA polymerase sigma factor, FliA/WhiG

RNA_pol_sigma_FliA_WhiG

4

IPR012846

12,846

Acetolactate synthase, large subunit, biosynthetic

Acetolactate_synth_lsu

Family

32,325

false

Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this entry also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyac...

[ "GO:0000287", "GO:0003984", "GO:0030976", "GO:0050660", "GO:0009082" ]

[ "magnesium ion binding", "acetolactate synthase activity", "thiamine pyrophosphate binding", "flavin adenine dinucleotide binding", "branched-chain amino acid biosynthetic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR00118" ]

[ "acolac_lg" ]

[ 32325 ]

1

[ "EC", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.2.1.6", "GenProp0162", "GenProp0163", "GenProp0164", "GenProp1342", "PWY-5101", "PWY-5103", "PWY-5104", "PWY-5938", "PWY-5939", "PWY-6389", "PWY-7111" ]

[ "EC:2.2.1.6", "GP:GenProp0162", "GP:GenProp0163", "GP:GenProp0164", "GP:GenProp1342", "METACYC:PWY-5101", "METACYC:PWY-5103", "METACYC:PWY-5104", "METACYC:PWY-5938", "METACYC:PWY-5939", "METACYC:PWY-6389", "METACYC:PWY-7111" ]

12

[ "1jsc", "1n0h", "1t9a", "1t9b", "1t9c", "1t9d", "1ybh", "1yhy", "1yhz", "1yi0", "1yi1", "1z8n", "3e9y", "3ea4", "5fem", "5ims", "5k2o", "5k3s", "5k6q", "5k6r", "5k6t", "5wj1", "5wkc", "6bd3", "6bd9", "6dek", "6del", "6dem", "6den", "6deo", "6dep", "6deq"...

52

[]

0

[ "IPR045229" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 796, 27530, 3606, 393 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 3, 1, 5, 1, 1, 8 ]

7

true

Family

Acetolactate synthase, large subunit, biosynthetic

Acetolactate_synth_lsu

7

IPR012847

12,847

Sucrose phosphatase, plant/cyanobacteria

Sucrose_phosphatase_pln/cyn

Family

1,647

false

This entry describes the sucrose phosphate phosphohydrolase from plants and cyanobacteria (SPP). However, a closely related group of sequences from bacteria and archaea may prove to catalyze the same reaction. SPP is a member of the Class IIB subfamily of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleop...

[ "GO:0000287", "GO:0050307", "GO:0005986" ]

[ "magnesium ion binding", "sucrose-phosphate phosphatase activity", "sucrose biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01485" ]

[ "SPP_plant-cyano" ]

[ 1647 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "3.1.3.24", "PWY-7238", "PWY-7347" ]

[ "EC:3.1.3.24", "METACYC:PWY-7238", "METACYC:PWY-7347" ]

3

[ "1s2o", "1tj3", "1tj4", "1tj5", "1u2s", "1u2t", "2b1q", "2b1r", "2d2v" ]

9

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 222, 1425 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 18, 6, 24 ]

3

true

Family

Sucrose phosphatase, plant/cyanobacteria

Sucrose_phosphatase_pln/cyn

2

IPR012848

12,848

Aspartic peptidase, N-terminal

Aspartic_peptidase_N

Domain

6,409

false

This entry represents the N-terminal domain of the aspartic peptidases.

[ "GO:0004190", "GO:0006508" ]

[ "aspartic-type endopeptidase activity", "proteolysis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07966" ]

[ "A1_Propeptide" ]

[ 6409 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "3.4.23", "GenProp1728", "R-CEL-2022377", "R-CFA-1442490", "R-CFA-2022377", "R-CFA-2132295", "R-CFA-5683826", "R-CFA-6798695", "R-CFA-77387", "R-HSA-1442490", "R-HSA-2022377", "R-HSA-2132295", "R-HSA-5683826", "R-HSA-6798695", "R-HSA-77387", "R-HSA-9018519", "R-MMU-1442490", "R-MMU...

[ "EC:3.4.23", "GP:GenProp1728", "REACTOME:R-CEL-2022377", "REACTOME:R-CFA-1442490", "REACTOME:R-CFA-2022377", "REACTOME:R-CFA-2132295", "REACTOME:R-CFA-5683826", "REACTOME:R-CFA-6798695", "REACTOME:R-CFA-77387", "REACTOME:R-HSA-1442490", "REACTOME:R-HSA-2022377", "REACTOME:R-HSA-2132295", "RE...

27

[ "1avf", "1htr", "1tzs", "2psg", "2x0b", "3psg", "3vcm", "4amt", "5mkt", "5ux4" ]

10

[ "PUB00000093", "PUB00000349", "PUB00001330" ]

[ "2194475", "1851433", "6795036" ]

[ "The structure and function of the aspartic proteinases.", "Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.", "Gastric proteinases--structure, function, evolution and mechanism of action." ]

[ 1990, 1991, 1981 ]

3

[]

0

null

[ "Eumetazoa", "Nocardioides humilatus" ]

[ 6408, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 1, 34, 26, 17 ]

6

true

Domain

Aspartic peptidase, N-terminal

Aspartic_peptidase_N

3

IPR012849

12,849

Abl-interactor, homeo-domain homologous domain

Abl-interactor_HHR_dom

Domain

8,173

false

The region is found towards the N terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases [ ]. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins [ ]. Other homeo-domain proteins have been implicat...

[]

0

[ "PFAM" ]

[ "PF07815" ]

[ "Abi_HHR" ]

[ 8173 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2029482", "R-HSA-4420097", "R-HSA-5663213", "R-HSA-9013149", "R-HSA-9013404", "R-HSA-9013423", "R-HSA-9664422", "R-MMU-2029482", "R-MMU-4420097", "R-MMU-5663213", "R-MMU-9013149", "R-MMU-9013404", "R-MMU-9013423", "R-RNO-2029482", "R-RNO-4420097", "R-RNO-5663213", "R-RNO-90131...

[ "REACTOME:R-HSA-2029482", "REACTOME:R-HSA-4420097", "REACTOME:R-HSA-5663213", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013423", "REACTOME:R-HSA-9664422", "REACTOME:R-MMU-2029482", "REACTOME:R-MMU-4420097", "REACTOME:R-MMU-5663213", "REACTOME:R-MMU-9013149", "REACTOM...

18

[ "3p8c", "4n78", "7usc", "7usd", "7use" ]

5

[ "PUB00016372", "PUB00016604" ]

[ "7590236", "12011975" ]

[ "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.", "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)." ]

[ 1995, 2002 ]

2

[]

0

null

[ "Metazoa" ]

[ 8173 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 52, 3, 18, 25, 25 ]

6

true

Domain

Abl-interactor, homeo-domain homologous domain

Abl-interactor_HHR_dom

6

IPR012850

12,850

Alpha-amylase, C-terminal beta-sheet

A-amylase_bs_C

Domain

3,672

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[ "GO:0004556", "GO:0005509", "GO:0005975" ]

[ "alpha-amylase activity", "calcium ion binding", "carbohydrate metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "SMART" ]

[ "PF07821", "SM00810" ]

[ "Alpha-amyl_C2", "Alpha-amyl_C2" ]

[ 3669, 3620 ]

2

[ "EC" ]

[ "3.2.1.1" ]

[ "EC:3.2.1.1" ]

1

[ "1amy", "1ava", "1bg9", "1ht6", "1p6w", "1rp8", "1rp9", "1rpk", "2qps", "2qpu", "3bsg", "3bsh", "3wn6" ]

13

[ "PUB00004870", "PUB00005266", "PUB00016439", "PUB00016510", "PUB00027666" ]

[ "7624375", "8535779", "9571044", "8196040", "11141191" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Molecular structure of a barley alpha-amylase-inhibitor complex: implications for starch binding and catalysis.", "Crystal and molecular struc...

[ 1995, 1995, 1998, 1994, 2001 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 173, 3497, 2 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 28, 24 ]

3

true

Domain

Alpha-amylase, C-terminal beta-sheet

A-amylase_bs_C

8

IPR012851

12,851

Spore coat protein CotF-like

Spore_coat_CotF-like

Family

5,847

false

The Coat F proteins contribute to the Bacillales spore coat. They occur multiple times in the genomes in which they are found. Bacillus subtilis endospore protein coats protect them and may play a role in their germination [ ]. Spore coat protein F, on the outer surface of the endospore, is one of a suite of proteins t...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07875", "PTHR39183" ]

[ "Coat_F", "" ]

[ 5430, 2943 ]

2

[]

0

[]

0

[ "PUB00044606", "PUB00044607" ]

[ "18723620", "14711677" ]

[ "Characterization of spores of Bacillus subtilis that lack most coat layers.", "Species differentiation of a diverse suite of Bacillus spores by mass spectrometry-based protein profiling." ]

[ 2008, 2004 ]

2

[]

[ "IPR016493", "IPR017022" ]

0

2

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5808, 5, 34 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Spore coat protein CotF-like

Spore_coat_CotF-like

4

IPR012852

12,852

Calcium binding and coiled-coil domain-like

CALCOCO1-like

Domain

2,561

false

Calcium-binding and coiled-coil domain-containing protein 1 (Calcoco1) from Mus musculus ( ) binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1 ( ), and thus enhances transcriptional activation by a number of nuclear receptors. Calcoco1 has a central coiled-coil region with three leucine ...

[]

0

[ "PFAM" ]

[ "PF07888" ]

[ "CALCOCO1" ]

[ 2561 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5357905", "R-BTA-936440", "R-HSA-5357905", "R-HSA-936440", "R-MMU-5357905", "R-MMU-936440", "R-RNO-5357905", "R-RNO-936440" ]

[ "REACTOME:R-BTA-5357905", "REACTOME:R-BTA-936440", "REACTOME:R-HSA-5357905", "REACTOME:R-HSA-936440", "REACTOME:R-MMU-5357905", "REACTOME:R-MMU-936440", "REACTOME:R-RNO-5357905", "REACTOME:R-RNO-936440" ]

8

[]

0

[ "PUB00016596" ]

[ "14690606" ]

[ "CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators." ]

[ 2003 ]

1

[]

0

null

[ "Bacillati", "Opisthokonta" ]

[ 36, 2525 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 29, 12, 6, 10 ]

4

true

Domain

Calcium binding and coiled-coil domain-like

CALCOCO1-like

6

IPR012853

12,853

Chloramphenicol phosphotransferase-like

CPT

Family

2,762

false

The members of this family are all similar to chloramphenicol 3-O phosphotransferase (CPT, ) expressed by Streptomyces venezuelae. Chloramphenicol (Cm) is a metabolite produced by this bacterium that can inhibit ribosomal peptidyl transferase activity and therefore protein production. By transferring a phosphate group ...

[ "GO:0005524", "GO:0016740" ]

[ "ATP binding", "transferase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PIRSF", "CDD" ]

[ "PF07931", "PIRSF007531", "cd00227" ]

[ "CPT", "CPT", "CPT" ]

[ 2762, 2059, 37 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.-", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-6626", "PWY-6682", "PWY-6955", "PWY-7077", "PWY-7321", "PWY-7740", "PWY-7769", "PWY-7886", "PWY-7948", "PWY-7975", "PWY-8129", "PWY-8324", "PWY-8367", "PWY-8392", "PWY-8393", "PWY-8394", "PWY-8402" ]

[ "EC:2.7.1.-", "METACYC:PWY-5129", "METACYC:PWY-6322", "METACYC:PWY-6369", "METACYC:PWY-6626", "METACYC:PWY-6682", "METACYC:PWY-6955", "METACYC:PWY-7077", "METACYC:PWY-7321", "METACYC:PWY-7740", "METACYC:PWY-7769", "METACYC:PWY-7886", "METACYC:PWY-7948", "METACYC:PWY-7975", "METACYC:PWY-8...

21

[ "1grq", "1grr", "1qhn", "1qhs", "1qhx", "1qhy" ]

6

[ "PUB00016586", "PUB00027902" ]

[ "11468347", "10835366" ]

[ "Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity.", "The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism." ]

[ 2001, 2000 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes", "uncultured Caudovirales phage" ]

[ 2646, 100, 2, 13, 1 ]

5

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Chloramphenicol phosphotransferase-like

CPT

3

IPR012854

12,854

Copper amine oxidase-like, N-terminal

Cu_amine_oxidase-like_N

Domain

21,514

false

Amine oxidases (AO) are enzymes that catalyse the oxidation of a wide range of biogenic amines including many neurotransmitters, histamine and xenobiotic amines. There are two classes of amine oxidases: flavin-containing ( ) and copper-containing ( ). Copper-containing AO act as a disulphide-linked homodimer. They cata...

[]

0

[ "PFAM" ]

[ "PF07833" ]

[ "Cu_amine_oxidN1" ]

[ 21514 ]

1

[ "EC", "GP" ]

[ "1.4.3.21", "GenProp1402" ]

[ "EC:1.4.3.21", "GP:GenProp1402" ]

2

[ "1d6u", "1d6y", "1d6z", "1dyu", "1jrq", "1lvn", "1oac", "1qaf", "1qak", "1qal", "1spu", "2w0q", "2wgq", "2wo0", "2wof", "2woh", "6ezz", "6grr", "8imd" ]

19

[ "PUB00005251", "PUB00010699", "PUB00010700", "PUB00010701", "PUB00016565" ]

[ "8591028", "9048544", "9405045", "8805580", "10576737" ]

[ "Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 A resolution.", "Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction.", "Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the...

[ 1995, 1997, 1997, 1996, 1999 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2, 21351, 15, 7, 139 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 2, 1 ]

2

true

Domain

Copper amine oxidase-like, N-terminal

Cu_amine_oxidase-like_N

3

IPR012856

12,856

D-aminopeptidase, domain B

DAP_B_dom

Domain

674

false

D-aminopeptidase ( ) is a dimeric enzyme with each monomer being composed of three domains. Domain B is organised to form a β barrel made up of eight antiparallel β strands. It is connected to domain A, the catalytic domain, by an eight-residue sequence, and also interacts with both domains A and C via non-covalent bon...

[ "GO:0004177" ]

[ "aminopeptidase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07930" ]

[ "DAP_B" ]

[ 674 ]

1

[ "EC" ]

[ "3.4.11.19" ]

[ "EC:3.4.11.19" ]

1

[ "1ei5" ]

1

[ "PUB00013322" ]

[ "10986464" ]

[ "Crystal structure of a D-aminopeptidase from Ochrobactrum anthropi, a new member of the 'penicillin-recognizing enzyme' family." ]

[ 2000 ]

1

[]

0

null

[ "Pseudomonadota", "bioreactor metagenome", "leotiomyceta" ]

[ 281, 1, 392 ]

3

[]

0

true

Domain

D-aminopeptidase, domain B

DAP_B_dom

1

IPR012858

12,858

Dendritic cell-specific transmembrane protein-like

DC_STAMP-like

Domain

4,592

false

This group of sequences is similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP, ). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins [ ]. It is thought to have seven putative transmembrane regions [ ], two of which are found ...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07782" ]

[ "DC_STAMP" ]

[ 4592 ]

1

[ "REACTOME" ]

[ "R-HSA-8874211" ]

[ "REACTOME:R-HSA-8874211" ]

1

[]

0

[ "PUB00016463" ]

[ "11169400" ]

[ "DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells." ]

[ 2000 ]

1

[]

0

null

[ "Eumetazoa", "Nocardioides malaquae" ]

[ 4591, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 52, 5, 9, 7, 10 ]

6

true

Domain

Dendritic cell-specific transmembrane protein-like

DC_STAMP-like

2

IPR012859

12,859

Archaeal Type IV pilin, N-terminal

Pilin_N_archaeal

Domain

2,821

false

This entry represents the N-terminal domain of archaeal pilins, which play important roles in surface adhesion. Sequences covered by this domain are not mixed up with sequences having such an extremely high sequence conservation as described in [ ].

[]

0

[ "PFAM" ]

[ "PF07790" ]

[ "Pilin_N" ]

[ 2821 ]

1

[]

0

[ "8fj5", "8gi2", "8rey" ]

3

[ "PUB00069628" ]

[ "23794623" ]

[ "Novel archaeal adhesion pilins with a conserved N terminus." ]

[ 2013 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Saline Natrinema sp. J7-1 virus 2", "unclassified sequences" ]

[ 2773, 2, 1, 45 ]

4

[]

0

true

Domain

Archaeal Type IV pilin, N-terminal

Pilin_N_archaeal

2

IPR012860

12,860

Arf3-interacting protein 1, N-terminal domain

Afi1_N

Domain

1,871

false

This domain occurs at the N terminus of Afi1 (Arf3-interacting protein 1), a protein necessary for vesicle trafficking in yeast. This domain is the interacting region of the protein which binds to Arf3. Afi1 is distributed asymmetrically at the plasma membrane and is required for polarized distribution of Arf3 but not ...

[]

0

[ "PFAM" ]

[ "PF07792" ]

[ "Afi1" ]

[ 1871 ]

1

[]

0

[]

0

[ "PUB00057274" ]

[ "18397879" ]

[ "Afi1p functions as an Arf3p polarization-specific docking factor for development of polarity." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1871 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 1 ]

4

true

Domain

Arf3-interacting protein 1, N-terminal domain

Afi1_N

7

IPR012861

12,861

Protein of unknown function DUF1634

DUF1634

Family

1,945

false

This family contains many hypothetical bacterial and archaeal proteins. A few members of this family are annotated as being putative transmembrane proteins, and the region in question in fact contains many hydrophobic residues.

[]

0

[ "PFAM" ]

[ "PF07843" ]

[ "DUF1634" ]

[ 1945 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 126, 1806, 13 ]

3

[]

0

true

Family

Protein of unknown function DUF1634

DUF1634

9

IPR012862

12,862

Protein of unknown function DUF1635

DUF1635

Family

2,544

false

The members of this family include sequences that are parts of hypothetical proteins expressed by plant species. The region in question is about 170 amino acids long.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07795", "PTHR33431" ]

[ "DUF1635", "" ]

[ 2541, 2469 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Embryophyta" ]

[ 2544 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 23, 5, 11 ]

3

true

Family

Protein of unknown function DUF1635

DUF1635

4

IPR012864

12,864

Cysteine oxygenase/2-aminoethanethiol dioxygenase

PCO/ADO

Family

6,306

false

This entry includes cysteine oxidases (PCOs) from plants and 2-aminoethanethiol dioxygenases (ADOs) from animals. PCOs oxidize N-terminal cysteine residues, thus preparing the protein for N-end rule pathway-mediated proteasomal degradation [ ]. ADO is responsible for endogenous cysteamine dioxygenase activity [ ].

[ "GO:0016702" ]

[ "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07847", "PTHR22966" ]

[ "PCO_ADO", "" ]

[ 6015, 6040 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.13.11.20", "PWY-5331", "R-DDI-1614558", "R-HSA-1614558", "R-MMU-1614558" ]

[ "EC:1.13.11.20", "METACYC:PWY-5331", "REACTOME:R-DDI-1614558", "REACTOME:R-HSA-1614558", "REACTOME:R-MMU-1614558" ]

5

[ "6s0p", "6s7e", "6sbp", "7chi", "7chj", "7cxz", "7lvz", "7rei", "8u9j", "8uan", "9dma", "9dxb", "9dxu", "9dxv", "9dy4" ]

15

[ "PUB00074379", "PUB00074380" ]

[ "24599061", "17581819" ]

[ "Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway.", "Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase." ]

[ 2014, 2007 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 27, 6278, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 24, 1, 3, 1, 3, 2, 308, 2, 59 ]

9

true

Family

Cysteine oxygenase/2-aminoethanethiol dioxygenase

PCO/ADO

1

IPR012865

12,865

Protein of unknown function DUF1642

DUF1642

Family

1,349

false

This entry represents a group of phage and prophage proteins whose function is not known.

[]

0

[ "PFAM" ]

[ "PF07852" ]

[ "DUF1642" ]

[ 1349 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobaculum halobium", "Viruses", "Zophobas morio" ]

[ 966, 1, 381, 1 ]

4

[]

0

true

Family

Protein of unknown function DUF1642

DUF1642

3

IPR012867

12,867

Domain of unknown function DUF1648

DUF1648

Domain

7,336

false

This domain is found in proteins expressed by bacterial and archaeal species. One such protein is immunity protein SdpI ( ) from Bacillus subtilis, which provides protection for the cell against the toxic effects of its own SdpC killing factor, and also functions as a receptor/signal transduction protein [ ].

[]

0

[ "PFAM" ]

[ "PF07853" ]

[ "DUF1648" ]

[ 7336 ]

1

[]

0

[]

0

[ "PUB00055038" ]

[ "16469701" ]

[ "A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 299, 6933, 50, 54 ]

4

[]

0

true

Domain

Domain of unknown function DUF1648

DUF1648

2

IPR012869

12,869

CopG-like ribbon-helix-helix domain

RHH_5

Domain

891

false

This entry represents a domain found in a group of bacterial proteins that form a ribbon-helix-helix fold. This fold occurs in many examples of bacterial antitoxins [ ].

[]

0

[ "PFAM" ]

[ "PF07878" ]

[ "RHH_5" ]

[ 891 ]

1

[]

0

[]

0

[ "PUB00075548" ]

[ "15864262" ]

[ "Prokaryotic toxin-antitoxin stress response loci." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Viruses", "metagenomes" ]

[ 11, 855, 9, 16 ]

4

[]

0

true

Domain

CopG-like ribbon-helix-helix domain

RHH_5

6

IPR012870

12,870

Protein of unknown function DUF1666

DUF1666

Family

3,099

false

These sequences are derived from hypothetical plant proteins of unknown function. The region in question is approximately 250 residues long.

[]

0

[ "PFAM" ]

[ "PF07891" ]

[ "DUF1666" ]

[ 3099 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Spermatophyta" ]

[ 3099 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 33, 9, 28 ]

3

true

Family

Protein of unknown function DUF1666

DUF1666

8

IPR012871

12,871

Protein of unknown function DUF1677, Oryza sativa

DUF1668_ORYSA

Family

4,407

false

The hypothetical proteins found in this family are expressed by Oryza sativa (Rice) and are of unknown function.

[]

0

[ "PFAM" ]

[ "PF07893" ]

[ "DUF1668" ]

[ 4407 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Motilibacter peucedani" ]

[ 4406, 1 ]

2

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 243, 10 ]

2

true

Family

Protein of unknown function DUF1677, Oryza sativa

DUF1668_ORYSA

2

IPR012873

12,873

Protein of unknown function DUF1672

DUF1672

Family

473

false

This family is composed of hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF07901" ]

[ "DUF1672" ]

[ 473 ]

1

[]

0

[ "4qpv" ]

1

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 471, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF1672

DUF1672

5

IPR012874

12,874

Protein of unknown function DUF1673, Methanosarcina species

DUF1673_METspp

Family

297

false

This family contains hypothetical proteins of unknown function found in Methanosarcina acetivorans and Methanosarcina mazei.

[]

0

[ "PFAM" ]

[ "PF07895" ]

[ "DUF1673" ]

[ 297 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanomicrobia", "ecological metagenomes" ]

[ 294, 3 ]

2

[]

0

true

Family

Protein of unknown function DUF1673, Methanosarcina species

DUF1673_METspp

8

IPR012875

12,875

Succinate dehydrogenase assembly factor 4

SDHF4

Family

6,893

false

This entry includes SDHF4 from animals, Sdh8 from budding yeasts and some uncharacterised proteins from bacteria. Sdh8 is required for assembly of succinate dehydrogenase (SDH). It interacts with the catalytic Sdh1 subunit in the mitochondrial matrix, facilitating its association with Sdh2 and the subsequent assembly o...

[]

0

[ "PFAM" ]

[ "PF07896" ]

[ "DUF1674" ]

[ 6893 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-9854311", "R-HSA-9854311", "R-MMU-9854311", "R-SCE-9854311", "R-SPO-9854311" ]

[ "REACTOME:R-DDI-9854311", "REACTOME:R-HSA-9854311", "REACTOME:R-MMU-9854311", "REACTOME:R-SCE-9854311", "REACTOME:R-SPO-9854311" ]

5

[ "2k5k", "8dyd", "8dye" ]

3

[ "PUB00092519" ]

[ "24954416" ]

[ "SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured virus" ]

[ 3054, 3808, 30, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 3, 2, 1, 1, 2, 3, 1, 1, 2 ]

12

true

Family

Succinate dehydrogenase assembly factor 4

SDHF4

3

IPR012876

12,876

Protein of unknown function DUF1677, plant

DUF1677_pln

Family

4,485

false

The sequences found in this family are all derived from hypothetical plant proteins of unknown function. The region features a number of highly conserved cysteine residues.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07911", "PTHR33108" ]

[ "DUF1677", "" ]

[ 4485, 4375 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4485 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 29, 44, 53 ]

3

true

Family

Protein of unknown function DUF1677, plant

DUF1677_pln

5

IPR012877

12,877

Uncharacterised oxidoreductase Dhs-27

Dhs-27

Family

2,238

false

This region is found in a number of Caenorhabditis elegans and Caenorhabditis briggsae proteins, in one case ( ) as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in zinc finger-C4 and HLH domain-containing kinases.

[]

0

[ "PFAM" ]

[ "PF07914" ]

[ "DUF1679" ]

[ 2238 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 45, 2193 ]

2

[ "Caenorhabditis elegans" ]

[ 37 ]

1

true

Family

Uncharacterised oxidoreductase Dhs-27

Dhs-27

6

IPR012878

12,878

Non-reducing end beta-L-arabinofuranosidase-like, GH127 catalytic domain

Beta-AFase-like_GH127_cat

Domain

16,879

false

This entry represents the catalytic domain of Non-reducing end beta-L-arabinofuranosidase from Bifidobacterium longum (Beta-AFase) and similar proteins widespread among all cellular organisms that belong to the glycoside hydrolase family 127 (GH127). This domain folds into an (α/α)6 barrel [ ]. Beta-AFase, an unusual b...

[]

0

[ "PFAM" ]

[ "PF07944" ]

[ "Beta-AFase-like_GH127_cat" ]

[ 16879 ]

1

[]

0

[ "3wkw", "3wkx", "3wre", "3wrf", "3wrg", "4qjy", "4qk0", "5mqo", "5opj", "6ex6", "6yqh", "7bzl", "7dif", "7exu", "7exv", "7exw", "8k7x", "8k7y", "8qf2", "8qf8" ]

20

[ "PUB00075450", "PUB00151606" ]

[ "24385433", "24680821" ]

[ "Characterization of a novel β-L-arabinofuranosidase in Bifidobacterium longum: functional elucidation of a DUF1680 protein family member.", "Crystal structure of glycoside hydrolase family 127 β-l-arabinofuranosidase from Bifidobacterium longum." ]

[ 2014, 2014 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 81, 13498, 3151, 149 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 10, 24 ]

3

true

Domain

Non-reducing end beta-L-arabinofuranosidase-like, GH127 catalytic domain

Beta-AFase-like_GH127_cat

7

IPR012879

12,879

PAT complex subunit CCDC47

CCDC47

Family

4,841

false

This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes [ ]. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by ...

[ "GO:0005509", "GO:0032469", "GO:0005783" ]

[ "calcium ion binding", "endoplasmic reticulum calcium ion homeostasis", "endoplasmic reticulum" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF07946", "PTHR12883" ]

[ "CCDC47", "" ]

[ 4827, 4777 ]

2

[]

0

[ "6w6l", "7tm3", "7tut", "9i78" ]

4

[ "PUB00097217", "PUB00097218", "PUB00097241", "PUB00097242", "PUB00097243" ]

[ "12475939", "32814900", "32820719", "30401460", "25009997" ]

[ "Different transmembrane domains associate with distinct endoplasmic reticulum components during membrane integration of a polytopic protein.", "An intramembrane chaperone complex facilitates membrane protein biogenesis.", "An ER translocon for multi-pass membrane protein biogenesis.", "Bi-allelic CCDC47 Vari...

[ 2002, 2020, 2020, 2018, 2014 ]

5

[]

0

null

[ "Candidatus Heimdallarchaeum aukensis", "Eukaryota" ]

[ 1, 4840 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 1, 2, 2, 4, 1, 4, 2, 1, 1, 10 ]

12

true

Family

PAT complex subunit CCDC47

CCDC47

9

IPR012880

12,880

Gryzun, putative trafficking through Golgi

Gryzun

Domain

1,653

false

The proteins featured in this family are all eukaryotic, and many of them are annotated as being Gryzun. Gryzun is distantly related to, but distinct from, the Trs130 subunit of the TRAPP complex but is absent from S. cerevisiae. RNAi of human Gryzun ( ) blocks Golgi exit. Thus the family is likely to be involved with ...

[]

0

[ "PFAM" ]

[ "PF07919" ]

[ "Gryzun" ]

[ 1653 ]

1

[]

0

[]

0

[ "PUB00075580" ]

[ "19942856" ]

[ "A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1653 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Gryzun, putative trafficking through Golgi

Gryzun

7

IPR012881

12,881

Protein of unknown function DUF1685

DUF1685

Family

4,078

false

The members of this family are hypothetical eukaryotic proteins of unknown function. The region in question is approximately 100 amino acid residues long.

[]

0

[ "PFAM" ]

[ "PF07939" ]

[ "DUF1685" ]

[ 4078 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Embryophyta" ]

[ 4078 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 48, 20, 27 ]

3

true

Family

Protein of unknown function DUF1685

DUF1685

2

IPR012883

12,883

ERp29, N-terminal

ERp29_N

Domain

1,274

false

ERp29 ( ) is a ubiquitously expressed endoplasmic reticulum protein, and is involved in the processes of protein maturation and protein secretion in this organelle [ , ]. The protein exists as a homodimer, with each monomer being composed of two domains. The N-terminal domain featured in this family is organised into a...

[ "GO:0009306", "GO:0005788" ]

[ "protein secretion", "endoplasmic reticulum lumen" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "CDD" ]

[ "PF07912", "cd03007" ]

[ "ERp29_N", "PDI_a_ERp29_N" ]

[ 1274, 243 ]

2

[]

0

[ "1g7e", "1ovn", "2c0e", "2c0f", "2c0g", "2c1y", "2qc7" ]

7

[ "PUB00014099", "PUB00016490", "PUB00029610" ]

[ "11435111", "10727933", "12941941" ]

[ "Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimer.", "Isolation of ERp29, a novel endoplasmic reticulum protein, from rat enamel cells evidence for a unique role in secretory-protein synthesis.", "Crystal struct...

[ 2001, 2000, 2003 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1274 ]

1

[ "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 2, 3 ]

4

true

Domain

ERp29, N-terminal

ERp29_N

8

IPR012885

12,885

Sdz-33, F-box domain

F-box_Sdz-33

Domain

4,855

false

This entry represents an F-box domain in Sdz-33, Sdz-15, Hecw-1 and uncharacterised proteins in Caenorhabditis elegans. F-box associated domain-containing protein SDZ-33 (Sdz-33) functions as the substrate recognition component of the E3 ubiquitin-protein ligase complex, mediating the ubiquitination and subsequent prot...

[]

0

[ "PFAM" ]

[ "PF07735" ]

[ "FBA_2" ]

[ 4855 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-CEL-4641258", "R-CEL-983168" ]

[ "REACTOME:R-CEL-4641258", "REACTOME:R-CEL-983168" ]

2

[]

0

[ "PUB00091144", "PUB00160782", "PUB00160783" ]

[ "22089131", "33514673", "2208913" ]

[ "Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.", "<i>Caenorhabditis elegans</i> F-Box Protein Promotes Axon Regeneration by Inducing Degradation of the Mad Transcription Factor.", "[Long-term experience with a PACS subsystem]." ]

[ 2011, 2021, 1990 ]

3

[]

0

null

[ "Caenorhabditis", "Thermodesulfobium acidiphilum" ]

[ 4854, 1 ]

2

[ "Caenorhabditis elegans" ]

[ 183 ]

1

true

Domain

Sdz-33, F-box domain

F-box_Sdz-33

8

IPR012886

12,886

Formiminotransferase, N-terminal subdomain

Formiminotransferase_N

Domain

5,185

false

The formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD) forms a homodimer, with each protomer being comprised of two subdomains. The formiminotransferase domain has an N-terminal subdomain that is made up of a six-stranded mixed β-pleated sheet and five α-helices, which are arranged on the ex...

[ "GO:0005542", "GO:0016740" ]

[ "folic acid binding", "transferase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "SMART" ]

[ "PF07837", "SM01222" ]

[ "FTCD_N", "FTCD_N" ]

[ 5179, 5087 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.2.5", "PWY-5030", "R-DDI-70921", "R-HSA-70921", "R-MMU-70921", "R-RNO-70921" ]

[ "EC:2.1.2.5", "METACYC:PWY-5030", "REACTOME:R-DDI-70921", "REACTOME:R-HSA-70921", "REACTOME:R-MMU-70921", "REACTOME:R-RNO-70921" ]

6

[ "1qd1", "1tt9", "2pfd" ]

3

[ "PUB00007432" ]

[ "10673422" ]

[ "The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme." ]

[ 2000 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 38, 1750, 3237, 160 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 22, 7, 1, 10, 2, 40 ]

7

true

Domain

Formiminotransferase, N-terminal subdomain

Formiminotransferase_N

7

IPR012887

12,887

GDP-fucose pyrophosphorylase domain

GDP_fucose_pyrophosphorylase

Domain

3,903

false

This entry represents the fucose pyrophosphorylase domain found at the N-terminal of the bifunctional L-Fucokinase/GDP-Fucose Pyrophosphorylase (FKP) enzymes such as FKGP from Arabidopsis and L-fucose kinase from animals [ , ]. In fucose-1-phosphate guanylyltransferase from human, this is the main domain of the protein...

[ "GO:0016772" ]

[ "transferase activity, transferring phosphorus-containing groups" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07959" ]

[ "Fucose_pyrophosphorylase" ]

[ 3903 ]

1

[ "EC", "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.7.1.52", "2.7.7.30", "PWY-6", "R-HSA-6787639", "R-MMU-6787639" ]

[ "EC:2.7.1.52", "EC:2.7.7.30", "METACYC:PWY-6", "REACTOME:R-HSA-6787639", "REACTOME:R-MMU-6787639" ]

5

[ "5yys", "9iis", "9iit" ]

3

[ "PUB00015901", "PUB00016201", "PUB00155376", "PUB00155377", "PUB00155378" ]

[ "9804772", "14686921", "15774760", "18199744", "30242642" ]

[ "GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme.", "Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose.", "Human symbionts use a host-like pathway for surface fucosylation.", "A bifunctional enzyme with L-fucokinase and GDP-L-fuco...

[ 1998, 2004, 2005, 2008, 2019 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 452, 3443, 8 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 2, 2, 15, 4, 5, 13, 7 ]

8

true

Domain

GDP-fucose pyrophosphorylase domain

GDP_fucose_pyrophosphorylase

9

IPR012889

12,889

L-fucose isomerase, N-terminal-2

Fucose_isomerase_N2

Domain

3,020

false

Proteins containing this domain are similar to L-fucose isomerase expressed by Escherichia coli ( , ). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis, and converts an aldo-hexose to a ketose to prepare it for aldol cleavage. The enzyme is a hexamer, with each subunit being wedge-shaped and compo...

[ "GO:0008736", "GO:0006004", "GO:0005737" ]

[ "L-fucose isomerase activity", "fucose metabolic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF07882" ]

[ "Fucose_iso_N2" ]

[ 3020 ]

1

[ "EC" ]

[ "5.3.1.25" ]

[ "EC:5.3.1.25" ]

1

[ "1fui", "3a9r", "3a9s", "3a9t", "4c20", "4c21", "4c22", "6k1f", "6k1g" ]

9

[ "PUB00007428" ]

[ "9367760" ]

[ "Structure and mechanism of L-fucose isomerase from Escherichia coli." ]

[ 1997 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 8, 2956, 4, 52 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

L-fucose isomerase, N-terminal-2

Fucose_isomerase_N2

3

IPR012891

12,891

GCK domain

GCK_dom

Domain

1,421

false

This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this entry ...

[]

0

[ "PFAM", "SMART" ]

[ "PF07802", "SM01227" ]

[ "GCK", "GCK" ]

[ 1366, 1376 ]

2

[]

0

[]

0

[ "PUB00099757" ]

[ "19011240" ]

[ "Structural and functional roles of the conserved cysteine residues of the redox-regulated import receptor Mia40 in the intermembrane space of mitochondria." ]

[ 2009 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1421 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 39, 5, 8 ]

3

true

Domain

GCK domain

GCK_dom

3

IPR012892

12,892

Gp58-like

Gp58

Domain

354

false

Sequences found in this entry are derived from a number of bacteriophage and prophage proteins. They are similar to gp58 ( ), a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H [ ].

[]

0

[ "PFAM" ]

[ "PF07902" ]

[ "Gp58" ]

[ 354 ]

1

[]

0

[]

0

[ "PUB00016531" ]

[ "7828907" ]

[ "Characterization of the genome region encoding structural proteins of Lactobacillus delbrueckii subsp. lactis bacteriophage LL-H." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Psylliodes chrysocephalus", "Viruses" ]

[ 314, 1, 39 ]

3

[]

0

true

Domain

Gp58-like

Gp58

2

IPR012893

12,893

HipA-like, C-terminal

HipA-like_C

Domain

17,708

false

The members of this entry are similar to a region close to the C terminus of the HipA protein expressed by various bacterial species (for example ). This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis [ ]. When expressed alone, ...

[]

0

[ "PFAM" ]

[ "PF07804" ]

[ "HipA_C" ]

[ 17708 ]

1

[]

0

[ "2wiu", "3akj", "3akk", "3akl", "3dnt", "3dnu", "3dnv", "3fbr", "3hzi", "3tpb", "3tpd", "3tpe", "3tpt", "3tpv", "4pu3", "4pu4", "4pu5", "4yg7", "5k98", "7ab3", "7ab4", "7ab5", "7vkb", "7vkc", "7wcf", "8ezr", "8ezs" ]

27

[ "PUB00016369", "PUB00016440", "PUB00055674" ]

[ "8021189", "1715862", "21098302" ]

[ "Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.", "Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.", "Helicobacter pylori proinflammatory protein up-regulates NF-kappaB as a cel...

[ 1994, 1991, 2010 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "IncJ plasmid R391", "Methanosarcinaceae", "Siphoviridae sp. ctg0K17", "unclassified sequences" ]

[ 17293, 29, 1, 5, 1, 379 ]

6

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

HipA-like, C-terminal

HipA-like_C

6

IPR012896

12,896

Integrin beta subunit, tail

Integrin_bsu_tail

Domain

11,507

false

This entry represents the tail domain of the integrin beta subunit. It forms a four-stranded β-sheet that contains parallel and antiparallel strands and faces an α helix found at the N terminus of this domain [ ]. Interactions between the α-helix and the β-sheet are mostly hydrophobic and involve a disulphide bond. The...

[]

0

[ "PFAM", "SMART" ]

[ "PF07965", "SM01242" ]

[ "Integrin_B_tail", "Integrin_B_tail" ]

[ 10080, 11497 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1566948", "R-BTA-166016", "R-BTA-198933", "R-BTA-202733", "R-BTA-2129379", "R-BTA-216083", "R-BTA-2173789", "R-BTA-3000178", "R-BTA-6798695", "R-CEL-114608", "R-CEL-1236973", "R-CEL-2129379", "R-CEL-216083", "R-CEL-2173789", "R-CEL-3000157", "R-CEL-3000170", "R-CEL-3000178", ...

[ "REACTOME:R-BTA-1566948", "REACTOME:R-BTA-166016", "REACTOME:R-BTA-198933", "REACTOME:R-BTA-202733", "REACTOME:R-BTA-2129379", "REACTOME:R-BTA-216083", "REACTOME:R-BTA-2173789", "REACTOME:R-BTA-3000178", "REACTOME:R-BTA-6798695", "REACTOME:R-CEL-114608", "REACTOME:R-CEL-1236973", "REACTOME:R-C...

158

[ "1jv2", "1l5g", "1m1x", "1u8c", "3fcs", "3ije", "3k6s", "3k71", "3k72", "4cak", "4g1e", "4g1m", "4mmx", "4mmy", "4mmz", "4neh", "4nen", "4o02", "4um8", "5es4", "6avq", "6avr", "6avu", "6bxj", "6mk0", "6msl", "6msu", "6naj", "7la4", "7nwl", "7nxd", "7usl"...

68

[ "PUB00006148", "PUB00009789", "PUB00015915", "PUB00015985", "PUB00026539", "PUB00035000", "PUB00035002", "PUB00057248", "PUB00160425" ]

[ "9009218", "12297042", "14689578", "2467745", "11546839", "12361595", "12234368", "12388743", "28510180" ]

[ "A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain.", "Integrins: bidirectional, allosteric signaling machines.", "Integrin clipping: a novel adhesion switch?", "A novel vitronectin receptor integrin (alpha v beta x...

[ 1997, 2002, 2004, 1989, 2001, 2002, 2002, 2002, 2014 ]

9

[]

0

null

[ "Metazoa" ]

[ 11507 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 28, 3, 32, 19, 32 ]

6

true

Domain

Integrin beta subunit, tail

Integrin_bsu_tail

3

IPR012897

12,897

Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain

K_chnl_volt-dep_Kv1.4_TID

Domain

688

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[ "GO:0005249", "GO:0030955", "GO:0006813", "GO:0016020" ]

[ "voltage-gated potassium channel activity", "potassium ion binding", "potassium ion transport", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF07941" ]

[ "K_channel_TID" ]

[ 688 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1296072", "R-MMU-1296072", "R-RNO-1296072" ]

[ "REACTOME:R-HSA-1296072", "REACTOME:R-MMU-1296072", "REACTOME:R-RNO-1296072" ]

3

[ "1kn7", "1zto" ]

2

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00007312", "PUB00008322", "PUB00009378", "PUB00009391", "PUB00016528", "PUB00036044" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "10798390", "9305895", "11178249", "10712896", "12590144", "11343973" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 2000, 1997, 2000, 2000, 2003, 2000 ]

12

[]

0

null

[ "Bacillati", "Opisthokonta" ]

[ 2, 686 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 3 ]

4

true

Domain

Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain

K_chnl_volt-dep_Kv1.4_TID

5

IPR012899

12,899

LTXXQ motif family protein

LTXXQ

Family

9,433

false

This family summarizes bacterial proteins related to CpxP, a periplasmic protein that forms part of a two-component system which acts as a global modulator of cell-envelope stress in Gram-negative bacteria. CpxP aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to al...

[ "GO:0042597" ]

[ "periplasmic space" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF", "CDD" ]

[ "PF07813", "PIRSF034445", "cd09916" ]

[ "LTXXQ", "CpxP_Spy", "CpxP_like" ]

[ 8874, 2799, 4696 ]

3

[]

0

[ "3itf", "3o39", "3oeo", "3qzc", "5ihf", "5io8", "5wnw", "5wo1", "5wo2", "5wo3", "6bie", "6owx", "6owy", "6owz" ]

14

[ "PUB00016508", "PUB00016553", "PUB00055384", "PUB00061476" ]

[ "9068658", "9473036", "20799348", "21239493" ]

[ "A new periplasmic protein of Escherichia coli which is synthesized in spheroplasts but not in intact cells.", "CpxP, a stress-combative member of the Cpx regulon.", "The crystal structure Escherichia coli Spy.", "Structural basis for two-component system inhibition and pilus sensing by the auxiliary CpxP pro...

[ 1997, 1998, 2010, 2011 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Thermococcus litoralis", "unclassified sequences" ]

[ 9324, 19, 1, 89 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

LTXXQ motif family protein

LTXXQ

8

IPR012900

12,900

G-box binding protein, multifunctional mosaic region

MFMR

Domain

3,421

false

This region is often found to the N terminus of the basic-leucine zipper domain ( ). It is between 150 and 200 amino acids in length. The N-terminal half of this domain is rich in proline residues and has been termed the PRD (proline rich domain) [ ], whereas the C-terminal half is more polar and has been called the MF...

[]

0

[ "PFAM" ]

[ "PF07777" ]

[ "MFMR" ]

[ 3421 ]

1

[]

0

[]

0

[ "PUB00016443", "PUB00016500" ]

[ "11722549", "8127687" ]

[ "Plant bZIP G-box binding factors. Modular structure and activation mechanisms.", "Novel conserved sequence motifs in plant G-box binding proteins and implications for interactive domains." ]

[ 2001, 1994 ]

2

[]

0

null

[ "Streptophytina" ]

[ 3421 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 23, 14, 54 ]

3

true

Domain

G-box binding protein, multifunctional mosaic region

MFMR

2

IPR012901

12,901

Carnosine N-methyltransferase

CARME

Family

6,098

false

This family includes Carnosine N-methyltransferase ( ), conserved from yeast to human, that catalyses the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. It a...

[ "GO:0008757" ]

[ "S-adenosylmethionine-dependent methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER", "SMART" ]

[ "PF07942", "PTHR12303", "SM01296" ]

[ "CARME", "", "N2227" ]

[ 6031, 6014, 5888 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.22", "R-DDI-70921", "R-DME-70921", "R-GGA-70921", "R-HSA-70921", "R-MMU-70921", "R-RNO-70921", "R-SCE-70921", "R-SPO-70921" ]

[ "EC:2.1.1.22", "REACTOME:R-DDI-70921", "REACTOME:R-DME-70921", "REACTOME:R-GGA-70921", "REACTOME:R-HSA-70921", "REACTOME:R-MMU-70921", "REACTOME:R-RNO-70921", "REACTOME:R-SCE-70921", "REACTOME:R-SPO-70921" ]

9

[ "5x62", "5yf0", "5yf1", "5yf2" ]

4

[ "PUB00098813", "PUB00098814", "PUB00098815", "PUB00158949" ]

[ "26001783", "29463897", "28654751", "38514639" ]

[ "UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase.", "Molecular basis for histidine N1 position-specific methylation by CARNMT1.", "Substrate Recognition Mechanism of the Putative Yeast Carnosine N-methyltransferase.", "An evolutionary mechanism to assimilate new nutrient sensors into t...

[ 2015, 2018, 2017, 2024 ]

4

[]

[ "IPR016853" ]

0

1

0

[ "Bacteria", "Eukaryota" ]

[ 29, 6069 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 2, 3, 1, 4, 1, 1, 3, 3, 2, 1, 10 ]

12

true

Family

Carnosine N-methyltransferase

CARME

1

IPR012902

12,902

Prokaryotic N-terminal methylation site

N_methyl_site

PTM

126,085

false

This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N terminus of pilins and other proteins involved in secretion (see , , and ).

[]

0

[ "PFAM", "PROSITE", "NCBIFAM" ]

[ "PF07963", "PS00409", "TIGR02532" ]

[ "N_methyl", "PROKAR_NTER_METHYL", "IV_pilin_GFxxxE" ]

[ 116930, 83217, 116067 ]

3

[ "GP" ]

[ "GenProp0295" ]

[ "GP:GenProp0295" ]

1

[ "1ay2", "1oqw", "2hi2", "2hil", "2m7g", "2pil", "3jc8", "3jc9", "3sok", "5g23", "5g24", "5kua", "5vxx", "5vxy", "5wda", "6gv9", "6vk9", "6xxd", "6xxe", "7tgg", "8p2v", "8p36", "8p3b", "8pfb", "8pij", "8piz", "8pjp", "8qqd", "8qqj", "8tj2", "8tob", "8tum"...

36

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 16, 123338, 51, 144, 2536 ]

5

[ "Escherichia coli (strain K12)" ]

[ 8 ]

1

true

PTM

Prokaryotic N-terminal methylation site

N_methyl_site

6

IPR012903

12,903

Nif11 domain

Nif11

Domain

1,625

false

This domain is found mainly in the Cyanobacteria and in Proteobacteria such as the nitrogen-fixing bacterium Azotobacter vinelandii. It is found in Nif11, a protein described in Azotobacter as linked to nitrogen fixation [ ]. It also constitutes a leader peptide in Nif11-derived peptides (N11P), which are thought to be...

[]

0

[ "PFAM" ]

[ "PF07862" ]

[ "Nif11" ]

[ 1625 ]

1

[]

0

[]

0

[ "PUB00016451", "PUB00055015", "PUB00068006" ]

[ "2644218", "20500830", "20479271" ]

[ "Physical and genetic map of the major nif gene cluster from Azotobacter vinelandii.", "Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family.", "Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobact...

[ 1989, 2010, 2010 ]

3

[]

[ "IPR022516" ]

0

1

0

[ "Bacteria", "Methanoplanus endosymbiosus", "Mycobacterium phage Mendokysei", "ecological metagenomes" ]

[ 1589, 5, 1, 30 ]

4

[]

0

true

Domain

Nif11 domain

Nif11

6

IPR012904

12,904

8-oxoguanine DNA glycosylase, N-terminal

OGG_N

Domain

7,197

false

The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity ( ) and DNA lyase acti...

[ "GO:0003684", "GO:0008534", "GO:0006289" ]

[ "damaged DNA binding", "oxidized purine nucleobase lesion DNA N-glycosylase activity", "nucleotide-excision repair" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF07934" ]

[ "OGG_N" ]

[ 7197 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.2.2.-", "4.2.99.18", "PWY-2681", "PWY-5316", "PWY-5381", "PWY-7342", "PWY-7564", "PWY-8106", "R-DME-110329", "R-DME-110330", "R-DME-110331", "R-DME-110357", "R-HSA-110328", "R-HSA-110329", "R-HSA-110330", "R-HSA-110331", "R-HSA-110357", "R-HSA-5649702", "R-HSA-9656255", "R-H...

[ "EC:3.2.2.-", "EC:4.2.99.18", "METACYC:PWY-2681", "METACYC:PWY-5316", "METACYC:PWY-5381", "METACYC:PWY-7342", "METACYC:PWY-7564", "METACYC:PWY-8106", "REACTOME:R-DME-110329", "REACTOME:R-DME-110330", "REACTOME:R-DME-110331", "REACTOME:R-DME-110357", "REACTOME:R-HSA-110328", "REACTOME:R-HSA...

34

[ "1ebm", "1fn7", "1hu0", "1ko9", "1lwv", "1lww", "1lwy", "1m3h", "1m3q", "1n39", "1n3a", "1n3c", "1yqk", "1yql", "1yqm", "1yqr", "2i5w", "2nob", "2noe", "2nof", "2noh", "2noi", "2nol", "2noz", "2xhi", "3f0z", "3f10", "3i0w", "3i0x", "3ih7", "3ktu", "4ejy"...

73

[ "PUB00013719", "PUB00016467" ]

[ "10706276", "11902834" ]

[ "Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.", "Reciprocal \"flipping\" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase." ]

[ 2000, 2002 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 549, 2186, 4409, 53 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 3, 3, 3, 14, 4, 1, 3, 4, 1, 4 ]

10

true

Domain

8-oxoguanine DNA glycosylase, N-terminal

OGG_N

6

IPR012905

12,905

PA-IL-like

PA-IL

Family

145

false

The members of this family are similar to the galactophilic lectin-1 expressed by Pseudomonas aeruginosa (PA-IL, ). Lectins recognising specific carbohydrates found on the surface of host cells are known to be involved in the initiation of infections by this organism. The protein is thought to be organised into an exte...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07828", "PIRSF020485" ]

[ "PA-IL", "PA-IL" ]

[ 145, 11 ]

2

[]

0

[ "1l7l", "1oko", "1uoj", "2vxj", "2wyf", "3zyb", "3zyf", "3zyh", "4a6s", "4al9", "4cp9", "4cpb", "4ljh", "4lk6", "4lk7", "4lkd", "4lke", "4lkf", "4yw6", "4yw7", "4ywa", "5d21", "5mih", "5odu", "5ofi", "5ofx", "5ofz", "6ygq", "6yo3", "6yoh", "7fio", "7fjh"...

38

[ "PUB00016484" ]

[ "1429650" ]

[ "Analysis of the amino acid sequence of the Pseudomonas aeruginosa galactophilic PA-I lectin." ]

[ 1992 ]

1

[]

0

null

[ "Acyrthosiphon pisum", "Bacteria" ]

[ 1, 144 ]

2

[]

0

true

Family

PA-IL-like

PA-IL

1

IPR012906

12,906

Transcriptional repressor PaaX-like, N-terminal

PaaX-like_N

Domain

8,167

false

This entry describes the N-terminal region of Transcriptional repressor PaaX from Escherichia coli and similar bacterial proteins. PaaX is involved in metabolism of phenylacetic acid [ , , ]. The gene product has been shown to bind to the promoter sites and repress their transcription [ ].

[]

0

[ "PFAM" ]

[ "PF07848" ]

[ "PaaX" ]

[ 8167 ]

1

[]

0

[ "3kfw", "3l09", "8a39" ]

3

[ "PUB00010200", "PUB00015494", "PUB00015522" ]

[ "9748275", "11260461", "10766858" ]

[ "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway.", "The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications.", "Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in ...

[ 1998, 2001, 2000 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "Siphoviridae sp. ctiMP24", "unclassified sequences" ]

[ 33, 8075, 2, 1, 56 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Transcriptional repressor PaaX-like, N-terminal

PaaX-like_N

1

IPR012907

12,907

Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal

Peptidase_S11_C

Domain

22,267

false

Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif...

[ "GO:0009002", "GO:0006508" ]

[ "serine-type D-Ala-D-Ala carboxypeptidase activity", "proteolysis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF07943", "SM00936" ]

[ "PBP5_C", "PBP5_C" ]

[ 22091, 20322 ]

2

[ "EC", "METACYC", "METACYC" ]

[ "3.4.16.4", "PWY-5265", "PWY-6471" ]

[ "EC:3.4.16.4", "METACYC:PWY-5265", "METACYC:PWY-6471" ]

3

[ "1hd8", "1nj4", "1nzo", "1nzu", "1sdn", "1xp4", "1z6f", "3a3j", "3beb", "3bec", "3it9", "3ita", "3itb", "3mfd", "3mzd", "3mze", "3mzf", "4drt", "4k91", "5fsr", "5j8x", "5tr7", "6ntz", "6osu" ]

24

[ "PUB00000522", "PUB00003576", "PUB00016400" ]

[ "8439290", "7845208", "10967102" ]

[ "Evolutionary families of peptidases.", "Families of serine peptidases.", "Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3-A resolution." ]

[ 1993, 1994, 2001 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Stx2-converting phage 1717", "unclassified sequences" ]

[ 22026, 41, 1, 199 ]

4

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal

Peptidase_S11_C

4

IPR012908

12,908

GPI inositol-deacylase PGAP1-like alpha/beta domain

PGAP1-ab_dom-like

Domain

10,150

false

This domain is found in GPI inositol-deacylase PGAP1 and related proteins. It is found toward the N terminus and it is a lipase domain with a typical α/β/α hydrolase architecture [ ]. PGAP1 is an endoplasmic reticulum membrane protein with a catalytic serine-containing motif that is conserved in a number of lipases. PG...

[ "GO:0016788" ]

[ "hydrolase activity, acting on ester bonds" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07819" ]

[ "PGAP1" ]

[ 10150 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-162791", "R-MMU-162791", "R-RNO-162791" ]

[ "REACTOME:R-HSA-162791", "REACTOME:R-MMU-162791", "REACTOME:R-RNO-162791" ]

3

[ "6wpx", "6wpy", "8k9q", "8k9r", "8k9t" ]

5

[ "PUB00055596", "PUB00094351", "PUB00155994" ]

[ "14734546", "6319176", "38167496" ]

[ "Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p.", "Hepatic adenylate cyclase and phosphodiesterase activity during acute ethionine intoxication.", "Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogen...

[ 2004, 1984, 2024 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "Viruses", "metagenomes" ]

[ 3564, 6550, 2, 5, 29 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 2, 1, 3, 1, 2, 6, 3, 1, 1, 26 ]

12

true

Domain

GPI inositol-deacylase PGAP1-like alpha/beta domain

PGAP1-ab_dom-like

6

IPR012909

12,909

PHA accumulation regulator DNA-binding, N-terminal

PHA_DNA-bd_N

Domain

5,168

false

This domain is found at the N terminus of the polyhydroxyalkanoate (PHA) synthesis regulators. These regulators have been shown to directly bind DNA and PHA [ ]. The invariant nature of this domain compared to the C-terminal domain(s) suggests that it contains the DNA-binding function.

[]

0

[ "PFAM" ]

[ "PF07879" ]

[ "PHB_acc_N" ]

[ 5168 ]

1

[]

0

[]

0

[ "PUB00013500" ]

[ "12081972" ]

[ "A repressor protein, PhaR, regulates polyhydroxyalkanoate (PHA) synthesis via its direct interaction with PHA." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5097, 9, 62 ]

3

[]

0

true

Domain

PHA accumulation regulator DNA-binding, N-terminal

PHA_DNA-bd_N

4

IPR012910

12,910

TonB-dependent receptor, plug domain

Plug_dom

Domain

352,625

false

This entry represents the plug domain, which has been shown to be an independently folding subunit of the TonB-dependent receptors [ ]. It acts as the channel gate, blocking the pore until the channel is bound by a ligand. At this point it undergoes conformational changes and opens the channel. In Escherichia coli the ...

[]

0

[ "PFAM" ]

[ "PF07715" ]

[ "Plug" ]

[ 352625 ]

1

[ "GP", "REACTOME", "REACTOME" ]

[ "GenProp0543", "R-HSA-9638334", "R-HSA-9638482" ]

[ "GP:GenProp0543", "REACTOME:R-HSA-9638334", "REACTOME:R-HSA-9638482" ]

3

[ "1by3", "1by5", "1fcp", "1fep", "1fi1", "1kmo", "1kmp", "1nqe", "1nqf", "1nqg", "1nqh", "1pnz", "1po0", "1po3", "1qff", "1qfg", "1qjq", "1qkc", "1ujw", "1xkh", "1xkw", "2fcp", "2grx", "2gsk", "2guf", "2hdf", "2hdi", "2iah", "2o5p", "2w16", "2w6t", "2w6u"...

152

[ "PUB00006673", "PUB00014980", "PUB00014981", "PUB00014984", "PUB00014986", "PUB00015225", "PUB00035726", "PUB00035727" ]

[ "9886293", "14499604", "9865695", "12652322", "11872840", "15111112", "15993072", "12957833" ]

[ "Crystal structure of the outer membrane active transporter FepA from Escherichia coli.", "The Escherichia coli outer membrane cobalamin transporter BtuB: structural analysis of calcium and substrate binding, and identification of orthologous transporters by sequence/structure conservation.", "Transmembrane sig...

[ 1999, 2003, 1998, 2003, 2002, 2004, 2005, 2003 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 5, 348587, 502, 18, 3513 ]

5

[ "Escherichia coli (strain K12)" ]

[ 10 ]

1

true

Domain

TonB-dependent receptor, plug domain

Plug_dom

4

IPR012911

12,911

Protein serine/threonine phosphatase 2C, C-terminal

PP2C_C

Domain

4,539

false

Protein phosphatase 2C (PP2C, also known as Protein phosphatase 1) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteristic of mammalian PP2Cs. This domain consists of three antiparallel α helices, one...

[ "GO:0000287", "GO:0004721", "GO:0030145" ]

[ "magnesium ion binding", "phosphoprotein phosphatase activity", "manganese ion binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PFAM" ]

[ "PF07830" ]

[ "PP2C_C" ]

[ 4539 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.16", "R-BTA-1169408", "R-BTA-2173795", "R-BTA-380972", "R-HSA-1169408", "R-HSA-2173795", "R-HSA-380972", "R-HSA-9700645", "R-HSA-9725370", "R-MMU-1169408", "R-MMU-2173795", "R-MMU-380972", "R-RNO-1169408", "R-RNO-2173795", "R-RNO-380972" ]

[ "EC:3.1.3.16", "REACTOME:R-BTA-1169408", "REACTOME:R-BTA-2173795", "REACTOME:R-BTA-380972", "REACTOME:R-HSA-1169408", "REACTOME:R-HSA-2173795", "REACTOME:R-HSA-380972", "REACTOME:R-HSA-9700645", "REACTOME:R-HSA-9725370", "REACTOME:R-MMU-1169408", "REACTOME:R-MMU-2173795", "REACTOME:R-MMU-38097...

15

[ "1a6q", "3fxj", "3fxk", "3fxl", "3fxm", "3fxo", "4ra2", "4raf", "4rag" ]

9

[ "PUB00001297" ]

[ "9003755" ]

[ "Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution." ]

[ 1996 ]

1

[]

0

null

[ "Metazoa" ]

[ 4539 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 16, 16, 13, 10, 19 ]

5

true

Domain

Protein serine/threonine phosphatase 2C, C-terminal

PP2C_C

3

IPR012912

12,912

Plasmid pRiA4b, Orf3-like domain

Plasmid_pRiA4b_Orf3-like

Domain

8,494

false

Members of this entry are similar to the protein product of ORF-3 ( ) found on plasmid pRiA4 in the bacterium Agrobacterium rhizogenes. This plasmid is responsible for tumorigenesis at wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process [ ]. O...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07929", "PTHR41878" ]

[ "PRiA4_ORF3", "" ]

[ 8493, 5307 ]

2

[]

0

[ "2i1s" ]

1

[ "PUB00016577" ]

[ "2226811" ]

[ "Characterization of the virA gene of the agropine-type plasmid pRiA4 of Agrobacterium rhizogenes." ]

[ 1990 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 182, 7422, 766, 124 ]

4

[]

0

true

Domain

Plasmid pRiA4b, Orf3-like domain

Plasmid_pRiA4b_Orf3-like

3

IPR012913

12,913

Protein OS9-like domain

OS9-like_dom

Domain

7,513

false

This entry represents a domain found in the OS9 protein, which is a lectin that functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD) [ ].

[]

0

[ "PFAM" ]

[ "PF07915" ]

[ "PRKCSH" ]

[ 7513 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-382556", "R-HSA-5358346", "R-HSA-5362768", "R-HSA-5678895", "R-HSA-901032", "R-MMU-382556", "R-MMU-5358346", "R-RNO-382556", "R-RNO-5358346", "R-SPO-5358346" ]

[ "REACTOME:R-HSA-382556", "REACTOME:R-HSA-5358346", "REACTOME:R-HSA-5362768", "REACTOME:R-HSA-5678895", "REACTOME:R-HSA-901032", "REACTOME:R-MMU-382556", "REACTOME:R-MMU-5358346", "REACTOME:R-RNO-382556", "REACTOME:R-RNO-5358346", "REACTOME:R-SPO-5358346" ]

10

[ "3aih", "6f99", "6f9a", "6vk3", "8kes", "8ket", "8kev", "9lwu", "9og0", "9uav" ]

10

[ "PUB00086554" ]

[ "17932042" ]

[ "OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum." ]

[ 2007 ]

1

[ "IPR044865" ]

[]

1

0

1

[ "Eukaryota", "bird metagenome" ]

[ 7511, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 3, 2, 44, 10, 1, 2, 11, 1, 2, 8 ]

12

true

Domain

Protein OS9-like domain

OS9-like_dom

5

IPR012914

12,914

Purine catabolism PurC-like domain

PucR_dom

Domain

16,084

false

This domain is found in the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR, ). PucR is thought to be a transcriptional regulator of genes involved in the purine degradation pathway, and may contain a LysR-like DNA-binding domain [ ]. It is similar to LysR-type regulators in that it represses ...

[]

0

[ "PFAM" ]

[ "PF07905" ]

[ "PucR" ]

[ 16084 ]

1

[]

0

[]

0

[ "PUB00016396", "PUB00057827" ]

[ "11344136", "12029039" ]

[ "Functional analysis of 14 genes that constitute the purine catabolic pathway in Bacillus subtilis and evidence for a novel regulon controlled by the PucR transcription activator.", "Transcription analysis of the Bacillus subtilis PucR regulon and identification of a cis-acting sequence required for PucR-regulate...

[ 2001, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 16033, 4, 47 ]

3

[]

0

true

Domain

Purine catabolism PurC-like domain

PucR_dom

3

IPR012916

12,916

RED-like, N-terminal

RED_N

Domain

4,263

false

This domain contains sequences that are similar to the N-terminal region of Red protein ( ). This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements [ ]. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region [ ], suggesting...

[]

0

[ "PFAM" ]

[ "PF07808" ]

[ "RED_N" ]

[ 4263 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

3

[ "5o9z", "6q8i", "8qo9", "8qzs" ]

4

[ "PUB00016574", "PUB00090272", "PUB00090273" ]

[ "10216252", "28781166", "22351768" ]

[ "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat.", "Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.", "RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activ...

[ 1999, 2017, 2012 ]

3

[]

0

null

[ "Acetivibrio clariflavus (strain DSM 19732 / NBRC 101661 / EBR45)", "Eukaryota" ]

[ 1, 4262 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 4, 1, 1, 1, 11, 6, 1, 5, 6, 1, 9 ]

11

true

Domain

RED-like, N-terminal

RED_N

5

IPR012917

12,917

Protein of unknown function DUF3294

DUF3294

Family

331

false

This family was annotated as mitochondrial ribosomal protein Mrp8, based on the presumed similarity of the S.cerevisiae protein to an E.coli mitochondrial ribosomal protein. However, this similarity is spurious, and the function is not known.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07957", "PIRSF022944" ]

[ "DUF3294", "Ribosomal_MRP8_mit" ]

[ 331, 59 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Candidatus Iainarchaeum sp.", "Eukaryota", "Pseudomonadota" ]

[ 1, 326, 4 ]

3

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF3294

DUF3294

2

IPR012918

12,918

RTP801-like

Family

2,244

false

RTP801, also known as REDD1, is the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene and is thought to be involved in various cellular processes [ ]. Both RTP801 and RTP801-like (REDD2) work downstream of AKT and upstream of TSC2 to inhibit mTOR, a serine/threonine kinase that plays an essential...

[ "GO:0009968", "GO:0005737" ]

[ "negative regulation of signal transduction", "cytoplasm" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF07809", "PTHR12478" ]

[ "RTP801_C", "" ]

[ 2243, 2218 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5628897", "R-DME-5628897", "R-DRE-5628897", "R-HSA-5628897", "R-MMU-5628897", "R-RNO-5628897", "R-XTR-5628897" ]

[ "REACTOME:R-BTA-5628897", "REACTOME:R-DME-5628897", "REACTOME:R-DRE-5628897", "REACTOME:R-HSA-5628897", "REACTOME:R-MMU-5628897", "REACTOME:R-RNO-5628897", "REACTOME:R-XTR-5628897" ]

7

[ "3lq9", "7mop" ]

2

[ "PUB00016594", "PUB00057842", "PUB00057843" ]

[ "11884613", "15632201", "16423342" ]

[ "Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.", "The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.", "scylla and charybde, homologues of the human apoptotic gene RTP801, are required for h...

[ 2002, 2005, 2006 ]

3

[]

0

null

[ "Eumetazoa" ]

[ 2244 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 5, 5, 5 ]

5

true

Family

RTP801-like

5

IPR012919

12,919

SUN domain

SUN_dom

Domain

19,313

false

Sad1/UNC-84 (SUN)-domain proteins are inner nuclear membrane (INM) proteins that are part of bridging complexes linking cytoskeletal elements with the nucleoskeleton. Originally identified based on an ~150-amino acid region of homology between the C terminus of the Schizosaccharomyces pombe Sad1 protein and the Caenorh...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF07738", "PS51469" ]

[ "Sad1_UNC", "SUN" ]

[ 18899, 16623 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-983168", "R-DME-983168", "R-HSA-1221632", "R-HSA-983168", "R-MMU-983168" ]

[ "REACTOME:R-CEL-983168", "REACTOME:R-DME-983168", "REACTOME:R-HSA-1221632", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]

5

[ "3unp", "4dxr", "4dxs", "4dxt", "4fi9", "5ed8", "5ywz", "6r15", "6r16", "6r2i", "6wmd", "6wme", "6wmf", "6wmg", "7z8y", "8b46", "8b5x" ]

17

[ "PUB00057231", "PUB00072664", "PUB00072665", "PUB00100392" ]

[ "15611647", "16923827", "19807882", "18820457" ]

[ "Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex.", "The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope.", "Characterization of SUN-domain proteins at the higher plant nuclear envelope.", "Drosophi...

[ 2004, 2006, 2010, 2007 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 12, 19300, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 23, 11, 57, 9, 38, 14, 2, 15, 32, 2, 2, 21 ]

12

true

Domain

SUN domain

SUN_dom

4

IPR012920

12,920

Ribosomal RNA methyltransferase, SPB1-like, C-terminal

rRNA_MeTfrase_SPB1-like_C

Domain

4,547

false

This domain is found at the C terminus SPB1-like proteins. This domain interacts with the meandering tail of Erb1 and its removal is required to form the pre-mature inter-subunit surface of the Arx1/Nog2 particle [ , ]. SPB1 is an adoMet-dependent rRNA methyltransferase required for proper assembly of pre-ribosomal par...

[ "GO:0008168", "GO:0006364", "GO:0005634" ]

[ "methyltransferase activity", "rRNA processing", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF07780" ]

[ "Spb1_C" ]

[ 4547 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

149

[ "6elz", "6em5", "6ylx", "7nac", "7nad", "7ohr", "7ohv", "7r6k", "7r6q", "7r72", "7r7a", "7u0h", "8esq", "8esr", "8etc", "8etj", "8fkp", "8fkq", "8fkr", "8fks", "8fkt", "8fku", "8fkv", "8fkw", "8fkx", "8fky", "8i9t", "8i9v", "8i9w", "8i9x", "8i9y", "8i9z"...

35

[ "PUB00016377", "PUB00056208", "PUB00068804", "PUB00068805", "PUB00100534", "PUB00100535" ]

[ "10556316", "15546625", "10648622", "22195017", "32668200", "29245012" ]

[ "Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae.", "Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage.", "Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p that is able to bind ...

[ 1999, 2004, 2000, 2011, 2020, 2017 ]

6

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4545, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 3, 2, 1, 2, 1, 1, 4, 2, 1, 1, 12 ]

12

true

Domain

Ribosomal RNA methyltransferase, SPB1-like, C-terminal

rRNA_MeTfrase_SPB1-like_C

8

IPR012921

12,921

Spen paralogue and orthologue SPOC, C-terminal

SPOC_C

Domain

14,460

false

Spen (split end) proteins regulate the expression of key transcriptional effectors in diverse signalling pathways. They are large proteins characterised by N-terminal RNA-binding motifs and a highly conserved C-terminal SPOC (Spen paralog and ortholog C-terminal) domain. The function of the SPOC domain is unknown, but ...

[]

0

[ "PFAM" ]

[ "PF07744" ]

[ "SPOC" ]

[ 14460 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1221632", "R-HSA-9013422", "R-HSA-9845323", "R-MMU-9013422" ]

[ "REACTOME:R-HSA-1221632", "REACTOME:R-HSA-9013422", "REACTOME:R-HSA-9845323", "REACTOME:R-MMU-9013422" ]

4

[ "1ow1", "2rt5", "4bxz", "5kxf", "6ic8", "6ic9", "6q2v", "6q5y", "7z1k", "7z27", "8ou1" ]

11

[ "PUB00013949" ]

[ "12897056" ]

[ "A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling." ]

[ 2003 ]

1

[]

[ "IPR010912" ]

0

1

0

[ "Eukaryota" ]

[ 14460 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 53, 2, 22, 6, 19, 13, 1, 17, 18, 1, 1, 33 ]

12

true

Domain

Spen paralogue and orthologue SPOC, C-terminal

SPOC_C

5

IPR012922

12,922

ORF D-335-like

ORF_D-335

Domain

123

false

The sequences featured in this family are similar to a probable integrase ( ) expressed by the SSV1 virus of the archaeon Sulfolobus shibatae. This protein may be necessary for the integration of the virus into the host genome by a process of site-specific recombination [ ].

[]

0

[ "PFAM" ]

[ "PF07935" ]

[ "SSV1_ORF_D-335" ]

[ 123 ]

1

[]

0

[]

0

[ "PUB00014897" ]

[ "1926776" ]

[ "Complete nucleotide sequence of the virus SSV1 of the archaebacterium Sulfolobus shibatae." ]

[ 1991 ]

1

[]

0

null

[ "Aporhodopirellula aestuarii", "Fuselloviridae", "Sulfolobaceae" ]

[ 1, 9, 113 ]

3

[]

0

true

Domain

ORF D-335-like

ORF_D-335

7

IPR012923

12,923

Chromosome segregation in meiosis protein 3

Csm3

Domain

3,984

false

This entry represents a domain found in a group of proteins, including Csm3 from budding yeasts, Swi3 from fission yeasts and TIPIN from animals. They are involved in DNA replication and the maintenance of replication fork stability [ , , ].

[ "GO:0006974", "GO:0031297", "GO:0005634" ]

[ "DNA damage response", "replication fork processing", "nucleus" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF07962" ]

[ "Swi3" ]

[ 3984 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-5693607", "R-HSA-5693607", "R-MMU-5693607", "R-RNO-5693607" ]

[ "REACTOME:R-DME-5693607", "REACTOME:R-HSA-5693607", "REACTOME:R-MMU-5693607", "REACTOME:R-RNO-5693607" ]

4

[ "6skl", "6xwx", "7pfo", "7plo", "7pmk", "7pmn", "8b9a", "8b9b", "8b9c", "8b9d", "8kg6", "8ouw", "8xgc", "9e2w", "9e2x" ]

15

[ "PUB00016387", "PUB00066967", "PUB00077532" ]

[ "15367656", "22842922", "17116885" ]

[ "Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.", "Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.", "Tipin and Timeless form a mutually protective complex required for genotoxic stress resist...

[ 2004, 2012, 2006 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3984 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 3, 2, 5, 4, 1, 3, 7, 1, 1, 4 ]

12

true

Domain

Chromosome segregation in meiosis protein 3

Csm3

8

IPR012924

12,924

TfuA-like, core

TfuA_core

Domain

1,686

false

This domain consists of a group of sequences that are similar to the core of TfuA protein ( ). TfuA plays a crucial dual role in peptide backbone thioamidation, functioning as both a hydrolase and a protein interaction mediator. It catalyses the hydrolysis of ThiS-COSH using a Ser/Lys catalytic pair to generate sulfide...

[]

0

[ "PFAM" ]

[ "PF07812" ]

[ "TfuA" ]

[ 1686 ]

1

[]

0

[ "6xp8" ]

1

[ "PUB00016421", "PUB00093716", "PUB00158997" ]

[ "8763943", "28880150", "33707784" ]

[ "A newly discovered gene, tfuA, involved in the production of the ribosomally synthesized peptide antibiotic trifolitoxin.", "Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea.", "Functional elucidation of TfuA in peptide backbone thioamidat...

[ 1996, 2017, 2021 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Sordariales", "ecological metagenomes", "uncultured Caudovirales phage" ]

[ 212, 1463, 2, 8, 1 ]

5

[]

0

true

Domain

TfuA-like, core

TfuA_core

3

IPR012925

12,925

TipAS antibiotic-recognition domain

TipAS_dom

Domain

10,416

false

TipAL is a bacterial transcriptional regulator of the MerR family. The tipA gene can be expressed as a long form, TipAL, and a short form, TipAS, which constitutes the C-terminal part of TipAL. TipAS forms the antibiotic-recognition domain [ ]. This domain, which has an α-helical globin-like fold, is also found at the ...

[]

0

[ "PFAM" ]

[ "PF07739" ]

[ "TipAS" ]

[ 10416 ]

1

[]

0

[ "1ny9", "2mbz", "2mc0", "3qao", "6et8", "6h95", "6h96", "6h97", "6hai", "7cla", "8rky" ]

11

[ "PUB00015229", "PUB00055552", "PUB00055553" ]

[ "12682015", "10200972", "10498730" ]

[ "Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators.", "Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters.", "Identification of a regulator that controls stationary-phase expression of catalase-peroxidase in Cau...

[ 2003, 1999, 1999 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes", "unclassified Caudoviricetes" ]

[ 10283, 8, 7, 116, 2 ]

5

[]

0

true

Domain

TipAS antibiotic-recognition domain

TipAS_dom

4

IPR012926

12,926

TMEM120A/B

Family

5,183

false

This entry represents a group of transmembrane proteins including TACAN (also known as TMEM120A) and TMEM120B. TMEM120A is involved in mechanosensation and plays an essential role in lipid metabolism and adipocyte differentiation [ , ]. It was first described as an ion channel that contributes to sensing mechanical pai...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07851", "PTHR21433" ]

[ "TMEM120A-B", "" ]

[ 5183, 5082 ]

2

[]

0

[ "7cxr", "7f3t", "7f3u", "7f6v", "7f73", "7n0k", "7n0l", "7n7p" ]

8

[ "PUB00094219", "PUB00094220", "PUB00158954", "PUB00158955", "PUB00158956", "PUB00158957" ]

[ "32084332", "26024229", "36420836", "34374645", "34409941", "34465718" ]

[ "TACAN Is an Ion Channel Involved in Sensing Mechanical Pain.", "TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation.", "Regulation of PKD2 channel function by TACAN.", "TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty ac...

[ 2020, 2015, 2023, 2021, 2021, 2021 ]

6

[]

0

null

[ "Eukaryota" ]

[ 5183 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 21, 1, 8, 3, 8, 5, 6, 8, 15 ]

9

true

Family

TMEM120A/B

6

IPR012927

12,927

Effector protease OspD3-like, N-terminal

Toxin_15_N

Domain

528

false

This domain is present in the N-terminal region of the ShET2 enterotoxin and the Effector protease OspD3 from Shigella flexneri, Ankyrin repeat protein A (ARPA) from Escherichia coli and related sequences from bacteria. OspD3 is an effector protease that disrupts necroptosis in host cells by mediating proteolytic cleav...

[]

0

[ "PFAM" ]

[ "PF07906" ]

[ "Toxin_15" ]

[ 528 ]

1

[]

0

[]

0

[ "PUB00084320", "PUB00162553" ]

[ "28085133", "32657447" ]

[ "EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation.", "A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8." ]

[ 2017, 2020 ]

2

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 521, 7 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Effector protease OspD3-like, N-terminal

Toxin_15_N

4

IPR012928

12,928

Clostridium neurotoxin, receptor binding N-terminal

Toxin_rcpt-bd_N

Domain

372

false

The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. These toxins act as inhibitors of neurotransmitter release [ , ]. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain ( ), the central translocation domai...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07953" ]

[ "Toxin_R_bind_N" ]

[ 372 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.69", "R-HSA-5250955", "R-HSA-5250958", "R-HSA-5250968", "R-HSA-5250971", "R-HSA-5250981", "R-HSA-5250982", "R-HSA-5250989", "R-HSA-5250992" ]

[ "EC:3.4.24.69", "REACTOME:R-HSA-5250955", "REACTOME:R-HSA-5250958", "REACTOME:R-HSA-5250968", "REACTOME:R-HSA-5250971", "REACTOME:R-HSA-5250981", "REACTOME:R-HSA-5250982", "REACTOME:R-HSA-5250989", "REACTOME:R-HSA-5250992" ]

9

[ "1a8d", "1af9", "1d0h", "1dfq", "1diw", "1dll", "1epw", "1f31", "1fv2", "1fv3", "1g9a", "1g9b", "1g9c", "1g9d", "1i1e", "1s0b", "1s0c", "1s0d", "1s0e", "1s0f", "1s0g", "1yxw", "1yyn", "1z0h", "2nm1", "2np0", "2nyy", "2nz9", "2vu9", "2vua", "2vxr", "3azv"...

150

[ "PUB00016466", "PUB00088575", "PUB00088576" ]

[ "9783750", "1328520", "23435179" ]

[ "Crystal structure of botulinum neurotoxin type A and implications for toxicity.", "Tetanus toxin inhibits depolarization-stimulated protein phosphorylation in rat cortical synaptosomes: effect on synapsin I phosphorylation and translocation.", "Botulinum toxins: mechanisms of action, antinociception and clinic...

[ 1998, 1992, 2013 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 332, 8, 27, 5 ]

4

[]

0

true

Domain

Clostridium neurotoxin, receptor binding N-terminal

Toxin_rcpt-bd_N

7

IPR012929

12,929

Nucleoprotein, TPR/MLP1-2 domain

Nucleoprot-TPR/MLP1-2_dom

Domain

4,575

false

This domain is found in several proteins, including TPR protein and yeast myosin-like protein 1 (MLP1) and MPL2. TPR and MLP1/2 share several features; for example, they have coiled-coil regions and are associated with nuclear pores [ , , ]. TPR is thought to be a component of nuclear pore complex-attached intranuclear...

[ "GO:0006606" ]

[ "protein import into nucleus" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF07926" ]

[ "TPR_MLP1_2" ]

[ 4575 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2036", "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-H...

[ "GP:GenProp2036", "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-55787...

86

[]

0

[ "PUB00016402", "PUB00016576", "PUB00075590", "PUB00075591" ]

[ "9024684", "7798308", "10085285", "12531921" ]

[ "Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments.", "Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.", "Proteins c...

[ 1997, 1994, 1999, 2003 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4575 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 4, 9, 2, 1, 3, 1, 1, 4, 1, 1, 38 ]

11

true

Domain

Nucleoprotein, TPR/MLP1-2 domain

Nucleoprot-TPR/MLP1-2_dom

1

IPR012930

12,930

TraC-like

TraC

Family

740

false

The members of this family are sequences that are similar to TraC ( ) from Rhizobium etli. The gene encoding this protein is one of a group of genes found on plasmid p42a of Rhizobium etli (strain CFN 42/ATCC 51251) that are thought to be involved in the process of plasmid self-transmission. Mobilisation of plasmid p42...

[]

0

[ "PFAM" ]

[ "PF07820" ]

[ "TraC" ]

[ 740 ]

1

[ "GP" ]

[ "GenProp0490" ]

[ "GP:GenProp0490" ]

1

[]

0

[ "PUB00016590" ]

[ "12591886" ]

[ "Conjugative transfer of p42a from rhizobium etli CFN42, which is required for mobilization of the symbiotic plasmid, is regulated by quorum sensing." ]

[ 2003 ]

1

[]

0

null

[ "Pseudomonadati", "marine sediment metagenome" ]

[ 739, 1 ]

2

[]

0

true

Family

TraC-like

TraC

2