interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR012931 | 12,931 | TraG, N-terminal, Proteobacteria | TraG_N_Proteobacteria | Domain | 5,427 | false | false | This domain is found in the N-terminal region of the TraG protein ( ) from Escherichia coli. This is a membrane-spanning protein, with three predicted transmembrane segments and two periplasmic regions [ ]. The TraG protein is known to be essential for DNA transfer in the process of conjugation, with the N-terminal por... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07916"
] | [
"TraG_N"
] | [
5427
] | 1 | [
"GP"
] | [
"GenProp0485"
] | [
"GP:GenProp0485"
] | 1 | [] | 0 | [
"PUB00016452",
"PUB00016567"
] | [
"7915817",
"1348105"
] | [
"Analysis of the sequence and gene products of the transfer region of the F sex factor.",
"Characterization of the F plasmid bifunctional conjugation gene, traG."
] | [
1994,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5358,
26,
43
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | TraG, N-terminal, Proteobacteria | TraG, N-terminal, Proteobacteria | TraG_N_Proteobacteria | 3 |
IPR012932 | 12,932 | Vitamin K epoxide reductase | VKOR | Domain | 11,707 | false | false | Vitamin K epoxide reductase (VKOR) recycles vitamin K 2,3-epoxide to vitamin K hydroquinone, a co-factor that is essential for the posttranslational γ-carboxylation of several blood coagulation factors [ ]. VKORC1, the catalytic subunit of the VKOR complex, is a member of a large family of predicted enzymes that are pr... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF07884",
"SM00756"
] | [
"VKOR",
"VKc"
] | [
11701,
9697
] | 2 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.17.4.4",
"PWY-7999",
"R-BTA-6806664",
"R-HSA-6806664",
"R-MMU-6806664",
"R-RNO-6806664"
] | [
"EC:1.17.4.4",
"METACYC:PWY-7999",
"REACTOME:R-BTA-6806664",
"REACTOME:R-HSA-6806664",
"REACTOME:R-MMU-6806664",
"REACTOME:R-RNO-6806664"
] | 6 | [
"3kp9",
"4nv2",
"4nv5",
"4nv6",
"6wv3",
"6wv4",
"6wv5",
"6wv6",
"6wv7",
"6wv8",
"6wv9",
"6wva",
"6wvb",
"6wvh",
"6wvi"
] | 15 | [
"PUB00016407",
"PUB00055212",
"PUB00057392",
"PUB00057393",
"PUB00057396",
"PUB00096863"
] | [
"15276181",
"20110994",
"18413314",
"18695247",
"14765194",
"24477003"
] | [
"Vitamin K epoxide reductase: homology, active site and catalytic mechanism.",
"Structure of a bacterial homologue of vitamin K epoxide reductase.",
"Identification of an atypical membrane protein involved in the formation of protein disulfide bonds in oxygenic photosynthetic organisms.",
"Bacterial species e... | [
2004,
2010,
2008,
2008,
2004,
2014
] | 6 | [] | [
"IPR041714",
"IPR044698"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Klosneuvirinae",
"metagenomes"
] | [
201,
8033,
3351,
5,
117
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
2,
4,
14,
9,
2,
23,
4
] | 8 | true | Domain | Vitamin K epoxide reductase | Vitamin K epoxide reductase | VKOR | 4 |
IPR012933 | 12,933 | HicA mRNA interferase family | HicA_mRNA_interferase | Family | 14,708 | false | false | This entry represents the HicA mRNA interferase family, which form the toxic component of a toxin-antitoxin (TA) module [ , ]. Family members contain a double-stranded RNA-binding domain and probably act as translation-independent mRNA interferases. They may form a complex with the antitoxin HicB which inhibits their m... | [
"GO:0003729"
] | [
"mRNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF07927"
] | [
"HicA_toxin"
] | [
14708
] | 1 | [] | [] | [] | 0 | [
"1whz",
"4c26",
"4p78",
"5yrz",
"6g26",
"6hpb"
] | 6 | [
"PUB00060548",
"PUB00060549"
] | [
"16895922",
"19060138"
] | [
"The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria.",
"HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea."
] | [
2006,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
854,
13095,
370,
134,
255
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | HicA mRNA interferase family | HicA mRNA interferase family | HicA_mRNA_interferase | 8 |
IPR012934 | 12,934 | Zinc finger, AD-type | Znf_AD | Domain | 27,133 | false | false | The zinc finger-associated domain (Znf-AD domain, also known as ZAD), is found at the N terminus of the C2H2 proteins of many arthropods [ ]. In vertebrates, only one protein containing an N-terminal structure similar to the ZAD has been found, Zinc finger protein 276. This domain forms an atypical treble-cleft-like zi... | [
"GO:0008270",
"GO:0005634"
] | [
"zinc ion binding",
"nucleus"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF07776",
"PS51915",
"SM00868"
] | [
"zf-AD",
"ZAD",
"zf-AD"
] | [
21649,
22934,
23754
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-212436",
"R-DME-214842",
"R-DME-214844",
"R-DME-214862",
"R-DME-214863",
"R-DME-214869",
"R-DME-214874",
"R-DME-6803204",
"R-DME-9843940"
] | [
"REACTOME:R-DME-212436",
"REACTOME:R-DME-214842",
"REACTOME:R-DME-214844",
"REACTOME:R-DME-214862",
"REACTOME:R-DME-214863",
"REACTOME:R-DME-214869",
"REACTOME:R-DME-214874",
"REACTOME:R-DME-6803204",
"REACTOME:R-DME-9843940"
] | 9 | [
"1pzw",
"6fp5",
"7po9",
"7pok",
"7ppp"
] | 5 | [
"PUB00014077",
"PUB00016985",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812",
"PUB00097542",
"PUB00097543",
"PUB00097544"
] | [
"12665246",
"14604529",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890",
"28740726",
"12446571",
"7569752"
] | [
"Zinc fingers--folds for many occasions.",
"The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger prot... | [
2002,
2003,
2007,
2005,
2005,
1999,
2001,
2017,
2002,
1995
] | 10 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"invertebrate metagenome"
] | [
3,
27129,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
188,
5,
3,
2
] | 5 | true | Domain | Zinc finger, AD-type | Zinc finger, AD-type | Znf_AD | 9 |
IPR012935 | 12,935 | NuBaID, N-terminal domain | NuBaID_N | Domain | 4,766 | false | false | This entry represents the N-terminal zinc finger domain (formerly ZnF-C3HC) of Zinc finger C3HC-type protein 1 (ZC3HC1, also known as Nuclear-interacting partner of ALK (NIPA)), pre-mRNA leakage protein 39 (Pml39), mRNA export factor Rsm1 and related eukaryotic proteins. Pml39 and Rsm1 are ZC3HC1 homologues from S. cer... | [
"GO:0008270"
] | [
"zinc ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF07967"
] | [
"zf-C3HC"
] | [
4766
] | 1 | [
"REACTOME"
] | [
"R-HSA-9725371"
] | [
"REACTOME:R-HSA-9725371"
] | 1 | [
"7rdn"
] | 1 | [
"PUB00014077",
"PUB00016374",
"PUB00016585",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812",
"PUB00053671",
"PUB00154435",
"PUB00154436",
"PUB00154437",
"PUB00154463",
"PUB00154464"
] | [
"12665246",
"15357289",
"12748172",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890",
"16009132",
"34440706",
"35609216",
"36857168",
"36271106",
"16162818"
] | [
"Zinc fingers--folds for many occasions.",
"Schizosaccharomyces pombe rsm1 genetically interacts with spmex67, which is involved in mRNA export.",
"Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).",
"Sticky fingers: zinc-fingers as protein-recognition ... | [
2002,
2004,
2003,
2007,
2005,
2005,
1999,
2001,
2005,
2021,
2022,
2023,
2022,
2005
] | 14 | [] | [] | 0 | 0 | null | [
"Betanudivirus hezeae",
"Eukaryota"
] | [
2,
4764
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
9,
1,
2,
7,
4,
1,
7,
3,
1,
1,
24
] | 11 | true | Domain | NuBaID, N-terminal domain | NuBaID, N-terminal domain | NuBaID_N | 3 |
IPR012936 | 12,936 | Endoplasmic reticulum vesicle transporter, C-terminal | Erv_C | Domain | 14,350 | false | false | This entry represents the C-terminal domain of the endoplasmic reticulum vesicle transporter proteins. Proteins included in this entry are conserved from plants and fungi to humans. Erv46 (ERGIC3) works in close conjunction with Erv41 (ERGIC2) and together they form a complex which cycles between the endoplasmic reticu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07970"
] | [
"COPIIcoated_ERV"
] | [
14350
] | 1 | [] | [] | [] | 0 | [
"3zlc"
] | 1 | [
"PUB00063190",
"PUB00089776"
] | [
"17077122",
"28444333"
] | [
"Genetic and molecular interactions of the Erv41p-Erv46p complex involved in transport between the endoplasmic reticulum and Golgi complex.",
"A Non-Classical Member of the Protein Disulfide Isomerase Family, PDI7 of Arabidopsis thaliana, Localizes to the cis-Golgi and Endoplasmic Reticulum Membranes."
] | [
2006,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
14350
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
32,
3,
9,
3,
24,
14,
2,
18,
13,
2,
2,
47
] | 12 | true | Domain | Endoplasmic reticulum vesicle transporter, C-terminal | Endoplasmic reticulum vesicle transporter, C-terminal | Erv_C | 2 |
IPR012937 | 12,937 | Terminal nucleotidyltransferase | TET5 | Family | 4,990 | false | false | This entry includes terminal nucleotidyltransferase 5A/B/C/D (TENT5A/B/C/D). In general, they contain a NTase (nucleotidyltransferase) domain, some members possess additional C-terminal PAP/OAS1 substrate binding domain [ ]. They are active non-canonical poly(A) polymerases, which modify cytosolic and/or nuclear RNA 3'... | [
"GO:1990817"
] | [
"poly(A) RNA polymerase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER",
"SMART"
] | [
"PF07984",
"PTHR12974",
"SM01153"
] | [
"NTP_transf_7",
"",
"DUF1693"
] | [
4989,
4969,
4876
] | 3 | [
"EC"
] | [
"2.7.7.19"
] | [
"EC:2.7.7.19"
] | 1 | [
"6jyj",
"6w36",
"6w38",
"6w3i",
"6w3j",
"7cqz",
"8eqb",
"8exe",
"8exf"
] | 9 | [
"PUB00066751",
"PUB00075453",
"PUB00090039",
"PUB00090040"
] | [
"19833706",
"17803723",
"27060136",
"28931820"
] | [
"Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human.",
"Genetic analysis of FAM46A in Spanish families with autosomal recessive retinitis pigmentosa: characterisation of novel VNTRs.",
"FAM46 proteins are novel eukaryotic non... | [
2009,
2008,
2016,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4990
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
8,
6,
10,
6,
9
] | 6 | true | Family | Terminal nucleotidyltransferase | Terminal nucleotidyltransferase | TET5 | 9 |
IPR012938 | 12,938 | Glucose/Sorbosone dehydrogenase | Glc/Sorbosone_DH | Domain | 38,126 | false | false | Proteins containing this domain are thought to be glucose/sorbosone dehydrogenases. The best characterised of these proteins is soluble glucose dehydrogenase ( ) from Acinetobacter calcoaceticus, which oxidises glucose to gluconolactone. The enzyme is a calcium-dependent homodimer which uses PQQ as a cofactor [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07995"
] | [
"GSDH"
] | [
38126
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5632681",
"R-MMU-5632681"
] | [
"REACTOME:R-HSA-5632681",
"REACTOME:R-MMU-5632681"
] | 2 | [
"1c9u",
"1cq1",
"1cru",
"1qbi",
"2g8s",
"2ism",
"2wft",
"2wfx",
"2wg3",
"2wg4",
"3a9g",
"3a9h",
"3das",
"3ho3",
"3ho4",
"3ho5",
"5min",
"7cdy",
"7cgz",
"7pgm",
"7pgn",
"8re0",
"8rfk",
"8rg1"
] | 24 | [
"PUB00016975"
] | [
"10508152"
] | [
"Structure and mechanism of soluble quinoprotein glucose dehydrogenase."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
826,
31730,
5114,
4,
452
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
13,
13,
1,
6,
3,
10,
7,
12
] | 8 | true | Domain | Glucose/Sorbosone dehydrogenase | Glucose/Sorbosone dehydrogenase | Glc/Sorbosone_DH | 3 |
IPR012939 | 12,939 | Glycosyl hydrolase family 92 | Glyco_hydro_92 | Domain | 24,643 | false | false | This domain occurs within alpha-1,2-mannosidases, which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07971"
] | [
"Glyco_hydro_92"
] | [
24643
] | 1 | [] | [] | [] | 0 | [
"2wvx",
"2wvy",
"2wvz",
"2ww0",
"2ww1",
"2ww2",
"2ww3",
"2wzs",
"2xsg",
"4aq0",
"5swi",
"6dwo",
"6f8z",
"6f90",
"6f91",
"6f92",
"7fe1",
"7fe2",
"7nsn",
"7zgm"
] | 20 | [
"PUB00016430"
] | [
"10026209"
] | [
"Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Argoarchaeum ethanivorans",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
19132,
1,
5298,
2,
210
] | 5 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
2
] | 2 | true | Domain | Glycosyl hydrolase family 92 | Glycosyl hydrolase family 92 | Glyco_hydro_92 | 5 |
IPR012940 | 12,940 | Nucleic acid binding NABP | NABP | Domain | 3,092 | false | false | This domain occurs in some putative nucleic acid binding proteins. One of these proteins has been partially characterised [ ] and contains two putative phosphorylation sites and a possible dimerisation / leucine zipper domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07990"
] | [
"NABP"
] | [
3092
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00016382"
] | [
"15488989"
] | [
"A cDNA homologue of Schizosaccharomyces pombe cdc5(+) from the mushroom Lentinula edodes: characterization of the cDNA and its expressed product."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3092
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
12,
28
] | 3 | true | Domain | Nucleic acid binding NABP | Nucleic acid binding NABP | NABP | 9 |
IPR012941 | 12,941 | Phenol hydroxylase-like, C-terminal dimerisation domain | Phe_hydrox_C_dim_dom | Domain | 8,977 | false | false | Phenol hydroxylase is a homodimer which hydroxylates phenol to catechol, or similar products. The enzyme is comprised of three domains. The first two domains form the active site. The third domain, this domain, is involved in forming the dimerisation interface. The domain adopts a thioredoxin-like fold [ ]. Protein con... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07976"
] | [
"Phe_hydrox_dim"
] | [
8977
] | 1 | [] | [] | [] | 0 | [
"1foh",
"1pn0",
"2dkh",
"2dki",
"7yj0",
"8r2u"
] | 6 | [
"PUB00016415",
"PUB00072938",
"PUB00082627",
"PUB00154503"
] | [
"9634698",
"18417078",
"24816227",
"36702957"
] | [
"The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis.",
"Examination and expansion of the substrate range of m-hydroxybenzoate hydroxylase.",
"Terrein biosynthesis in Aspergillus terreu... | [
1998,
2008,
2014,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
1709,
7261,
7
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
5
] | 1 | true | Domain | Phenol hydroxylase-like, C-terminal dimerisation domain | Phenol hydroxylase-like, C-terminal dimerisation domain | Phe_hydrox_C_dim_dom | 2 |
IPR012942 | 12,942 | SRR1-like domain | SRR1-like | Domain | 5,985 | false | false | This domain is found in SRR1-like proteins. SRR1 are signalling proteins thought to be involved in regulating the circadian clock input pathway, which is required for normal oscillator function. In Arabidopsis thaliana it regulates the expression of clock-regulated genes such as CCA1 and TOC1. It is also involved in bo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07985"
] | [
"SRR1"
] | [
5985
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00016530",
"PUB00073052",
"PUB00090476"
] | [
"12533513",
"18064466",
"28802827"
] | [
"The Arabidopsis SRR1 gene mediates phyB signaling and is required for normal circadian clock function.",
"The evolutionary conserved BER1 gene is involved in microtubule stability in yeast.",
"The novel heme-dependent inducible protein, SRRD regulates heme biosynthesis and circadian rhythms."
] | [
2003,
2008,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5985
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
12,
1,
2,
2,
1,
14,
4,
1,
1,
2
] | 12 | true | Domain | SRR1-like domain | SRR1-like domain | SRR1-like | 8 |
IPR012943 | 12,943 | Centrosomin, N-terminal motif 1 | Cnn_1N | Domain | 6,741 | false | false | This domain (Cnn_1N) is a short conserved motif found in the N-terminal of a group of centrosome or spindle pole body (SPB) associated proteins, including Mto1 and Pcp1 from S. pombe [ , ], centrosomin from flies [ , ] and myomegalin/CDK5RAP2 from mammals [ , ]. | [
"GO:0005815"
] | [
"microtubule organizing center"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF07989"
] | [
"Cnn_1N"
] | [
6741
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518",
"R-RNO-2565942",
"R-RNO-380259",
"R-RNO-380270",
"R-... | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 21 | [
"6x0v",
"9g3y",
"9g3z",
"9g40",
"9h9p",
"9qvm"
] | 6 | [
"PUB00016981",
"PUB00045027",
"PUB00075360",
"PUB00075361",
"PUB00075362",
"PUB00075363",
"PUB00075364"
] | [
"15004232",
"11864908",
"17671162",
"10357928",
"11134006",
"18042621",
"24656740"
] | [
"Identification and characterization of two novel proteins affecting fission yeast gamma-tubulin complex function.",
"Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe.",
"Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centr... | [
2004,
2002,
2007,
1999,
2001,
2007,
2014
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
6737
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
81,
7,
39,
12,
2,
21,
2
] | 7 | true | Domain | Centrosomin, N-terminal motif 1 | Centrosomin, N-terminal motif 1 | Cnn_1N | 6 |
IPR012944 | 12,944 | RagB/SusD domain | SusD_RagB_dom | Domain | 72,766 | false | false | This domain is found in bacterial cell surface proteins such as SusD and SusD-like proteins as as well RagB, an outer membrane surface receptor antigen. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07980"
] | [
"SusD_RagB"
] | [
72766
] | 1 | [
"GP"
] | [
"GenProp0941"
] | [
"GP:GenProp0941"
] | 1 | [
"3ck7",
"3ck8",
"3ck9",
"3ckb",
"3ckc",
"3hdx",
"3i4g",
"3ihv",
"3iv0",
"3jq0",
"3jq1",
"3jys",
"3kez",
"3l22",
"3lew",
"3mcx",
"3myv",
"3nqp",
"3otn",
"3qnk",
"3snx",
"4l7t",
"5cjz",
"5ck0",
"5ck1",
"5cx8",
"5e75",
"5e76",
"5lx8",
"5t3r",
"5t4y",
"6gcz"... | 56 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
71911,
45,
6,
804
] | 4 | [] | [] | 0 | true | Domain | RagB/SusD domain | RagB/SusD domain | SusD_RagB_dom | 3 |
IPR012945 | 12,945 | Tubulin binding cofactor C-like domain | Tubulin-bd_cofactor_C_dom | Domain | 8,643 | false | false | This domain is found in tubulin-binding cofactor C (or tubulin-specific chaperone C) (TBCC) and in protein XRP2. TBCC is a folding cofactor that participates in tubulin biogenesis along with the other tubulin folding cofactors A (TBCA), B (TBCB), E (TBCE) and D (TBCD), as well as the GTP-binding protein Arl2 [ , ]. XRP... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF07986",
"PIRSF037947"
] | [
"TBCC",
"Protein_XRP2_"
] | [
8638,
1153
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-5624138",
"R-GGA-5624138",
"R-HSA-389977",
"R-HSA-5624138",
"R-MMU-5624138"
] | [
"REACTOME:R-DRE-5624138",
"REACTOME:R-GGA-5624138",
"REACTOME:R-HSA-389977",
"REACTOME:R-HSA-5624138",
"REACTOME:R-MMU-5624138"
] | 5 | [
"2bx6",
"2yuh",
"3bh6",
"3bh7",
"5aj8",
"9m1m",
"9m1n"
] | 7 | [
"PUB00016983",
"PUB00042572",
"PUB00066954"
] | [
"12225668",
"17184771",
"18376416"
] | [
"Functional analysis of the tubulin-folding cofactor C in Arabidopsis thaliana.",
"Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation.",
"The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3."
] | [
2002,
2007,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8643
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
18,
4,
6,
1,
5,
4,
2,
9,
14,
1,
26
] | 11 | true | Domain | Tubulin binding cofactor C-like domain | Tubulin binding cofactor C-like domain | Tubulin-bd_cofactor_C_dom | 1 |
IPR012946 | 12,946 | X8 domain | X8 | Domain | 28,873 | false | false | The X8 domain [ ] contains 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is found in an Olive pollen allergen [ ] as well as at the C terminus of family 17 glycosyl hydrolases [ ]. This domain may be involved in carbohydrate binding. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF07983",
"SM00768"
] | [
"X8",
"X8"
] | [
28631,
28786
] | 2 | [] | [] | [] | 0 | [
"2jon",
"2w61",
"2w62",
"2w63",
"5fih",
"5o9o",
"5o9p",
"5o9q",
"5o9r",
"5o9y",
"5oa2",
"5oa6",
"8pe1",
"8pe2"
] | 14 | [
"PUB00016520",
"PUB00016575",
"PUB00020563"
] | [
"15004167",
"11115868",
"11554480"
] | [
"A major allergen from pollen defines a novel family of plant proteins and shows intra- and interspecies [correction of interspecie] cross-reactivity.",
"Glycoside hydrolases and glycosyltransferases. Families, modules, and implications for genomics.",
"A census of carbohydrate-active enzymes in the genome of A... | [
2004,
2000,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Rugosimonospora acidiphila"
] | [
28872,
1
] | 2 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
290,
1,
145,
2,
2,
259
] | 6 | true | Domain | X8 domain | X8 domain | X8 | 6 |
IPR012947 | 12,947 | Threonyl/alanyl tRNA synthetase, SAD | tRNA_SAD | Domain | 83,915 | false | false | The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional dom... | [
"GO:0004812",
"GO:0005524",
"GO:0043039"
] | [
"aminoacyl-tRNA ligase activity",
"ATP binding",
"tRNA aminoacylation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM",
"SMART"
] | [
"PF07973",
"SM00863"
] | [
"tRNA_SAD",
"tRNA_SAD"
] | [
82961,
82932
] | 2 | [
"EC",
"REACTOME",
"REACTOME"
] | [
"6.1.1",
"R-HSA-379716",
"R-HSA-379726"
] | [
"EC:6.1.1",
"REACTOME:R-HSA-379716",
"REACTOME:R-HSA-379726"
] | 3 | [
"1nyq",
"1nyr",
"1qf6",
"1tje",
"1tke",
"1tkg",
"1tky",
"1v4p",
"1wxo",
"2e1b",
"2ztg",
"2zze",
"2zzf",
"2zzg",
"3kew",
"3rfn",
"3rhu",
"3wqy",
"3wqz",
"6vu9",
"9iuw"
] | 21 | [
"PUB00006444"
] | [
"10319817"
] | [
"The structure of threonyl-tRNA synthetase-tRNA(Thr) complex enlightens its repressor activity and reveals an essential zinc ion in the active site."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2213,
60672,
19704,
8,
1318
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
26,
4,
10,
11,
2,
26,
22,
3,
10,
25,
3,
2,
40
] | 13 | true | Domain | Threonyl/alanyl tRNA synthetase, SAD | Threonyl/alanyl tRNA synthetase, SAD | tRNA_SAD | 8 |
IPR012948 | 12,948 | AARP2CN | AARP2CN | Domain | 9,465 | false | false | This domain is the central domain of AARP2 (asparagine and aspartate rich protein 2). It is weakly similar to the GTP-binding domain of elongation factor TU [ ]. PfAARP2 is an antigen from Plasmodium falciparum of 150kDa, which is encoded by a unique gene on chromosome 1 [ ]. The central region of Pfaarp2 contains bloc... | [
"GO:0042254",
"GO:0005634"
] | [
"ribosome biogenesis",
"nucleus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF08142",
"SM00785"
] | [
"AARP2CN",
"AARP2CN"
] | [
9402,
9429
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 5 | [
"5iw7",
"5jpq",
"5oql",
"5wlc",
"5wwn",
"5wyj",
"5wyk",
"6eml",
"6fai",
"6g18",
"6g4s",
"6g4w",
"6g51",
"6g53",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6rbd",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6wdr",
"6y7c",
"6zmt"... | 84 | [
"PUB00016366",
"PUB00043402"
] | [
"15112237",
"9247928"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"Plasmodium falciparum asparagine and aspartate rich protein 2 is an evolutionary conserved protein whose repeats identify a new family of parasite antigens."
] | [
2004,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9465
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
14,
2,
3,
2,
4,
6,
2,
7,
8,
2,
2,
15
] | 12 | true | Domain | AARP2CN | AARP2CN | AARP2CN | 7 |
IPR012950 | 12,950 | Alpha enterocin/lactococcin | Alpha_enterocin/lactococcin | Family | 11 | false | false | This entry consists of the alpha enterocins and lactococcin G peptides. These peptides have some antimicrobial properties; they inhibit the growth of Enterococcus spp. and a few other Gram-positive bacteria. These peptides act as pore-forming toxins that create cell membrane channels through a barrel-stave mechanism an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08129"
] | [
"Antimicrobial17"
] | [
11
] | 1 | [] | [] | [] | 0 | [
"2jpj",
"2jpl"
] | 2 | [
"PUB00016478"
] | [
"10742203"
] | [
"Characterization and cloning of the genes encoding enterocin 1071A and enterocin 1071B, two antimicrobial peptides produced by Enterococcus faecalis BFE 1071."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
11
] | 1 | [] | [] | 0 | true | Family | Alpha enterocin/lactococcin | Alpha enterocin/lactococcin | Alpha_enterocin/lactococcin | 6 |
IPR012951 | 12,951 | Berberine/berberine-like | BBE | Domain | 45,273 | false | false | This domain is found in the berberine bridge and berberine bridge-like enzymes, flavoproteins which have an unusual bicovalent attachment of the FAD cofactor that are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyse the transformation of the N-methyl group of (S)-reticuline into the C-8 be... | [
"GO:0016491",
"GO:0050660"
] | [
"oxidoreductase activity",
"flavin adenine dinucleotide binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF08031"
] | [
"BBE"
] | [
45273
] | 1 | [] | [] | [] | 0 | [
"1zr6",
"2axr",
"2bvf",
"2bvg",
"2bvh",
"2ipi",
"2wdw",
"2y08",
"2y3r",
"2y3s",
"2y4g",
"3d2d",
"3d2h",
"3d2j",
"3fw7",
"3fw8",
"3fw9",
"3fwa",
"3gsy",
"3hsu",
"3pop",
"3pqb",
"3rj8",
"3rja",
"3tsh",
"3tsj",
"3vte",
"3w8w",
"3w8x",
"3w8z",
"4dns",
"4ec3"... | 79 | [
"PUB00016512",
"PUB00095663"
] | [
"8972604",
"26037923"
] | [
"Molecular characterization of berberine bridge enzyme genes from opium poppy.",
"Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism."
] | [
1996,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
344,
12107,
32761,
20,
41
] | 5 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
117,
11,
35,
31
] | 4 | true | Domain | Berberine/berberine-like | Berberine/berberine-like | BBE | 9 |
IPR012952 | 12,952 | BING4, C-terminal domain | BING4_C_dom | Domain | 4,217 | false | false | This C-terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins [ ]. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF08149",
"SM01033"
] | [
"BING4CT",
"BING4CT"
] | [
4216,
4211
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6791226",
"R-CFA-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-CEL-6791226",
"REACTOME:R-CFA-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 7 | [
"5oql",
"5wlc",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"7suk",
"9g33"... | 42 | [
"PUB00016366"
] | [
"15112237"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4217
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
1,
9,
5,
1,
2,
3,
1,
1,
4
] | 12 | true | Domain | BING4, C-terminal domain | BING4, C-terminal domain | BING4_C_dom | 4 |
IPR012953 | 12,953 | BOP1, N-terminal domain | BOP1_N_dom | Domain | 4,724 | false | false | This domain is found in the N-terminal region of BOP1-like WD40 proteins. Bop1 is a nucleolar protein involved in rRNA processing, thereby controlling the cell cycle [ ]. It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in ribosome formation that coordinates proc... | [
"GO:0006364"
] | [
"rRNA processing"
] | [
"biological_process"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF08145",
"SM01035"
] | [
"BOP1NT",
"BOP1NT"
] | [
4724,
4614
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6791226",
"R-DDI-6791226",
"R-DME-6791226",
"R-HSA-6791226",
"R-MMU-6791226",
"R-RNO-6791226",
"R-SCE-6791226",
"R-SPO-6791226",
"R-XTR-6791226"
] | [
"REACTOME:R-CEL-6791226",
"REACTOME:R-DDI-6791226",
"REACTOME:R-DME-6791226",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226",
"REACTOME:R-XTR-6791226"
] | 9 | [
"4u7a",
"6c0f",
"6cb1",
"6elz",
"6em1",
"6em3",
"6em4",
"6em5",
"7nac",
"7nad",
"7ohp",
"7ohr",
"7ohs",
"7ohv",
"7ohw",
"7ohx",
"7r6k",
"7r6q",
"7r72",
"7r7a",
"7r7c",
"8e5t",
"8esq",
"8esr",
"8etg",
"8eth",
"8eti",
"8eug",
"8eui",
"8eup",
"8euy",
"8ev3"... | 55 | [
"PUB00043628"
] | [
"16362343"
] | [
"Interaction of beta-giardin with the Bop1 protein in Giardia lamblia."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"metagenomes"
] | [
4722,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
1,
7,
4,
1,
1,
2,
1,
1,
4
] | 12 | true | Domain | BOP1, N-terminal domain | BOP1, N-terminal domain | BOP1_N_dom | 3 |
IPR012954 | 12,954 | BP28, C-terminal domain | BP28_C_dom | Domain | 4,481 | false | false | This domain is found in the C-terminal of BAP28 proteins [ ] (which are involved in nucleolar processing of pre-18S ribosomal RNA and ribosome biosynthesis [ ]) and in other BAP28-like proteins. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF08146",
"SM01036"
] | [
"BP28CT",
"BP28CT"
] | [
4481,
4412
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6791226",
"R-DDI-6791226",
"R-DME-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-CEL-6791226",
"REACTOME:R-DDI-6791226",
"REACTOME:R-DME-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 7 | [
"5jpq",
"5oql",
"5wlc",
"5wyk",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9"... | 47 | [
"PUB00016366",
"PUB00043646"
] | [
"15112237",
"16531401"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous system."
] | [
2004,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4481
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
3,
1,
9,
5,
1,
4,
3,
1,
1,
6
] | 12 | true | Domain | BP28, C-terminal domain | BP28, C-terminal domain | BP28_C_dom | 1 |
IPR012955 | 12,955 | CASP, C-terminal | CASP_C | Domain | 4,352 | false | false | This domain is the C-terminal region of the CASP family of proteins. These are Golgi membrane proteins which are thought to have a role in vesicle transport [ ]. | [
"GO:0006891",
"GO:0000139"
] | [
"intra-Golgi vesicle-mediated transport",
"Golgi membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF08172"
] | [
"CASP_C"
] | [
4352
] | 1 | [
"REACTOME"
] | [
"R-HSA-6811438"
] | [
"REACTOME:R-HSA-6811438"
] | 1 | [] | 0 | [
"PUB00016380"
] | [
"12429822"
] | [
"CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4352
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"S... | [
4,
1,
2,
3,
9,
1,
5,
3,
1,
1,
6
] | 11 | true | Domain | CASP, C-terminal | CASP, C-terminal | CASP_C | 4 |
IPR012956 | 12,956 | CARG-binding factor, N-terminal | CARG-binding_factor_N | Domain | 1,860 | false | false | This N-terminal domain is found in CARG-binding factor A-like proteins [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08143"
] | [
"CBFNT"
] | [
1860
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-450408",
"R-HSA-72163",
"R-HSA-72203",
"R-MMU-450408",
"R-MMU-72163",
"R-MMU-72203",
"R-RNO-450408",
"R-RNO-72163",
"R-RNO-72203"
] | [
"REACTOME:R-HSA-450408",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72203",
"REACTOME:R-MMU-450408",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72203",
"REACTOME:R-RNO-450408",
"REACTOME:R-RNO-72163",
"REACTOME:R-RNO-72203"
] | 9 | [] | 0 | [
"PUB00016366"
] | [
"15112237"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1860
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
16,
11,
12
] | 4 | true | Domain | CARG-binding factor, N-terminal | CARG-binding factor, N-terminal | CARG-binding_factor_N | 5 |
IPR012957 | 12,957 | CHD, C-terminal 2 | CHD_C2 | Domain | 6,944 | false | false | This entry represents the C-terminal domain of CHD (Chromodomain, Helicase, DNA-binding) proteins. CHD3 and CHD4 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription [ ]. CHD5 forms a NuR... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08074"
] | [
"CHDCT2"
] | [
6944
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"3.6.4.-",
"PWY-7250",
"R-CEL-4551638",
"R-CEL-6804758",
"R-CEL-9031628",
"R-DME-3214815",
"R-DME-6804758",
"R-DME-8943724",
"R-DME-9031628",
"R-HSA-3214815",
"R-HSA-427389",
"R-HSA-4551638",
"R-HSA-6804758",
"R-HSA-73762",
"R-HSA-8943724",
"R-HSA-9031628",
"R-HSA-9679191",
"R-HSA-... | [
"EC:3.6.4.-",
"METACYC:PWY-7250",
"REACTOME:R-CEL-4551638",
"REACTOME:R-CEL-6804758",
"REACTOME:R-CEL-9031628",
"REACTOME:R-DME-3214815",
"REACTOME:R-DME-6804758",
"REACTOME:R-DME-8943724",
"REACTOME:R-DME-9031628",
"REACTOME:R-HSA-3214815",
"REACTOME:R-HSA-427389",
"REACTOME:R-HSA-4551638",
... | 25 | [
"6ryr",
"6ryu",
"8d4y"
] | 3 | [
"PUB00069084",
"PUB00069676",
"PUB00085033"
] | [
"23954449",
"23340908",
"24419087"
] | [
"CHD chromatin remodelling enzymes and the DNA damage response.",
"The NuRD architecture.",
"Role of CHD5 in human cancers: 10 years later."
] | [
2013,
2013,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Shewanella electrica"
] | [
6943,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
22,
17,
29,
15,
21
] | 6 | true | Domain | CHD, C-terminal 2 | CHD, C-terminal 2 | CHD_C2 | 2 |
IPR012959 | 12,959 | CPL domain | CPL_dom | Domain | 4,224 | false | false | This C-terminal domain is found in Penguin-like proteins (CPL) and is associated with Pumilio like repeats [ ]. | [
"GO:0003723"
] | [
"RNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF08144"
] | [
"CPL"
] | [
4224
] | 1 | [] | [] | [] | 0 | [
"4wzr",
"4wzw",
"8ia0"
] | 3 | [
"PUB00016366"
] | [
"15112237"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4224
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
2,
1,
2,
2,
1,
2,
6,
1,
1,
7
] | 12 | true | Domain | CPL domain | CPL domain | CPL_dom | 9 |
IPR012961 | 12,961 | ATP-dependent RNA helicase Ski2/MTR4, C-terminal | Ski2/MTR4_C | Domain | 16,935 | false | false | This C-terminal domain is found in Ski2/MTR4/helY-like DEAD box helicases [ , ]. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF08148",
"SM01142"
] | [
"DSHCT",
"DSHCT"
] | [
16921,
16688
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.4",
"R-CEL-6791226",
"R-CEL-72163",
"R-CEL-9930044",
"R-HSA-390471",
"R-HSA-429958",
"R-HSA-6791226",
"R-HSA-72163",
"R-HSA-9843970",
"R-HSA-9930044",
"R-MMU-429958",
"R-MMU-6791226",
"R-MMU-72163",
"R-MMU-9930044",
"R-SCE-429958",
"R-SCE-6791226",
"R-SPO-429958",
"R-SPO-67912... | [
"EC:3.6.4",
"REACTOME:R-CEL-6791226",
"REACTOME:R-CEL-72163",
"REACTOME:R-CEL-9930044",
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-429958",
"REACTOME:R-HSA-6791226",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-9843970",
"REACTOME:R-HSA-9930044",
"REACTOME:R-MMU-429958",
"REACTOME:R-MMU-6791226",
"... | 19 | [
"2xgj",
"4a4z",
"4buj",
"4qu4",
"4u4c",
"4xgt",
"5dzr",
"5e02",
"5mc6",
"5ooq",
"6bb8",
"6c90",
"6d6q",
"6d6r",
"6fsz",
"6ft6",
"6ieg",
"6ieh",
"6lqs",
"6ro1",
"7ajt",
"7aju",
"7d4i",
"7qdr",
"7qds",
"7qdy",
"7qdz",
"7qe0",
"7s7b",
"7s7c",
"7z4y",
"7z4z"... | 43 | [
"PUB00016366",
"PUB00058447"
] | [
"15112237",
"22114319"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"The crystal structure of S. cerevisiae Ski2, a DExH helicase associated with the cytoplasmic functions of the exosome."
] | [
2004,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
5232,
11270,
18,
415
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
18,
2,
4,
3,
22,
8,
2,
13,
11,
2,
3,
32
] | 12 | true | Domain | ATP-dependent RNA helicase Ski2/MTR4, C-terminal | ATP-dependent RNA helicase Ski2/MTR4, C-terminal | Ski2/MTR4_C | 4 |
IPR012962 | 12,962 | Peptidase M54, archaemetzincin | Pept_M54_archaemetzincn | Family | 3,986 | false | false | Peptidase family M54 (archaemetzincin or archaelysin) is a zinc-dependent aminopeptidase that contains the consensus zinc-binding sequence HEXXHXXGXXH/D and a conserved Met residue at the active site, and is thus classified as a metzincin. Archaemetzincins, first identified in archaea, are also found in bacteria and eu... | [
"GO:0008233",
"GO:0006508"
] | [
"peptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER",
"CDD"
] | [
"PF07998",
"PTHR15910",
"cd11375"
] | [
"Peptidase_M54",
"",
"Peptidase_M54"
] | [
3038,
2588,
3600
] | 3 | [] | [] | [] | 0 | [
"2x7m",
"3lmc",
"3zvs",
"4a3w",
"4axq"
] | 5 | [
"PUB00044926",
"PUB00059804",
"PUB00079687"
] | [
"16879646",
"20597090",
"20561058"
] | [
"Recruitment of a novel zinc-bound transcriptional factor by a bacterial HMGA-type protein is required for regulating multiple processes in Myxococcus xanthus.",
"Crystal structure of archaemetzincin AmzA from Methanopyrus kandleri at 1.5 A resolution.",
"The regulatory action of the myxobacterial CarD/CarG com... | [
2006,
2010,
2010
] | 3 | [] | [
"IPR012091"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
643,
774,
2518,
3,
48
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
8,
4
] | 4 | true | Family | Peptidase M54, archaemetzincin | Peptidase M54, archaemetzincin | Pept_M54_archaemetzincn | 5 |
IPR012963 | 12,963 | HAAS transmembrane region | HAAS_TM | Domain | 638 | false | false | This entry represents the transmembrane region (TM) fused to HAAS (HTH-associated α-helical signaling) domain found in a number of hypothetical bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08006"
] | [
"HAAS_TM"
] | [
638
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
638
] | 1 | [] | [] | 0 | true | Domain | HAAS transmembrane region | HAAS transmembrane region | HAAS_TM | 5 |
IPR012964 | 12,964 | Protein of unknown function DUF1702 | DUF1702 | Family | 1,058 | false | false | This family of proteins contains many bacterial proteins that are encoded by the unbL gene. The function of these proteins is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08012"
] | [
"DUF1702"
] | [
1058
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"hydrothermal vent metagenome"
] | [
1057,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF1702 | Protein of unknown function DUF1702 | DUF1702 | 1 |
IPR012965 | 12,965 | Meiotically up-regulated protein Msb1/Mug8 domain | Msb1/Mug8_dom | Domain | 1,948 | false | false | This domain of unknown function is found in fungal proteins, including Mug8 from Schizosaccharomyces pombe which may have a role in meiosis and septation [ ]. Saccharomyces cerevisiae homologue MSB1( ) may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08101"
] | [
"Msb1-Mug8_dom"
] | [
1948
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044889",
"PUB00087082"
] | [
"16303567",
"12399379"
] | [
"A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.",
"Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae."
] | [
2005,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1948
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Meiotically up-regulated protein Msb1/Mug8 domain | Meiotically up-regulated protein Msb1/Mug8 domain | Msb1/Mug8_dom | 1 |
IPR012966 | 12,966 | Anillin homology domain | AHD | Domain | 7,002 | false | false | Anillin is a protein involved in septin organisation during cell division. It is an actin binding protein that is localised to the cleavage furrow, and it maintains the localisation of active myosin, which ensures the spatial control of concerted contraction during cytokinesis [ ]. This entry represents a conserved dom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08174"
] | [
"Anillin"
] | [
7002
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8980692",
"R-CEL-9013026",
"R-DME-8980692",
"R-DME-9013026",
"R-HSA-5666185",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-MMU-5666185",
"R-MMU-8980692",
"R-MMU-9013026",
"R-MMU-9013106",
"R-RNO-5666185",
"R-RNO-8980692",
"R-RNO-9013026"
] | [
"REACTOME:R-CEL-8980692",
"REACTOME:R-CEL-9013026",
"REACTOME:R-DME-8980692",
"REACTOME:R-DME-9013026",
"REACTOME:R-HSA-5666185",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013026",
"REACTOME:R-HSA-9013106",
"REACTOME:R-MMU-5666185",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013026",
"REACTOM... | 15 | [
"4xh3",
"4xoi"
] | 2 | [
"PUB00075569",
"PUB00075570"
] | [
"16040610",
"18158243"
] | [
"Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis.",
"Anillin is a scaffold protein that links RhoA, actin, and myosin during cytokinesis."
] | [
2005,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
7001,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
7,
21,
1,
9,
9,
2,
20
] | 7 | true | Domain | Anillin homology domain | Anillin homology domain | AHD | 5 |
IPR012967 | 12,967 | Caffeic acid 3-O-methyltransferase-like, dimerisation domain | COMT-like_dimerisation | Domain | 35,076 | false | false | This domain is found at the N-terminal in a variety of Caffeic acid 3-O-methyltransferase (COMT) and related O-methyltransferases. It has been shown to mediate dimerisation of these proteins [ , ]. It is also found in some N-methyltransferases such as Anthranilate N-methyltransferase and 3-aminomethylindole N-methyltra... | [
"GO:0046983"
] | [
"protein dimerization activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF08100"
] | [
"Dimerisation"
] | [
35076
] | 1 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1",
"GenProp1388",
"R-BTA-209931",
"R-DDI-209931",
"R-HSA-209931",
"R-MMU-209931",
"R-RNO-209931"
] | [
"EC:2.1.1",
"GP:GenProp1388",
"REACTOME:R-BTA-209931",
"REACTOME:R-DDI-209931",
"REACTOME:R-HSA-209931",
"REACTOME:R-MMU-209931",
"REACTOME:R-RNO-209931"
] | 7 | [
"1fp1",
"1fp2",
"1fpq",
"1kyw",
"1kyz",
"1qzz",
"1r00",
"1tw2",
"1tw3",
"1x19",
"1x1a",
"1x1b",
"1x1c",
"1x1d",
"1xds",
"1xdu",
"1zg3",
"1zga",
"1zgj",
"1zhf",
"2ip2",
"2qyo",
"2r3s",
"3gwz",
"3gxo",
"3i53",
"3i58",
"3i5u",
"3i64",
"3lst",
"3mcz",
"3p9c"... | 139 | [
"PUB00006319",
"PUB00016422",
"PUB00026870",
"PUB00054125",
"PUB00057957",
"PUB00057958",
"PUB00155948",
"PUB00155949"
] | [
"7897657",
"11224575",
"12084826",
"12826405",
"16225687",
"21858014",
"16930646",
"17988223"
] | [
"Universal catalytic domain structure of AdoMet-dependent methyltransferases.",
"Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases.",
"Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic ac... | [
1995,
2001,
2002,
2003,
2005,
2011,
2006,
2008
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
187,
10252,
24569,
68
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
70,
6,
8,
2,
92,
2,
121
] | 7 | true | Domain | Caffeic acid 3-O-methyltransferase-like, dimerisation domain | Caffeic acid 3-O-methyltransferase-like, dimerisation domain | COMT-like_dimerisation | 5 |
IPR012968 | 12,968 | FerIin domain | FerIin_dom | Domain | 9,758 | false | false | The ferlin gene family are characterised by multiple tandem C2 domains and a C-terminal transmembrane domain. They are found in a wide range of species and their function remains unknown, however, mutations in its two most well-characterised members, dysferlin and otoferlin, have been implicated in human disease [ ]. T... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF08151",
"SM01202"
] | [
"FerI",
"FerI"
] | [
8890,
9751
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-445355",
"R-HSA-9609523",
"R-HSA-9662360"
] | [
"REACTOME:R-HSA-445355",
"REACTOME:R-HSA-9609523",
"REACTOME:R-HSA-9662360"
] | 3 | [
"9b8k",
"9b8l",
"9h6x",
"9qe2",
"9qkv",
"9qle",
"9qlf",
"9qln",
"9qls",
"9se5",
"9sea",
"9seg",
"9sfl",
"9sh0",
"9si1"
] | 15 | [
"PUB00016366",
"PUB00054013"
] | [
"15112237",
"20667140"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins."
] | [
2004,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9758
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
104,
2,
8,
24,
24
] | 5 | true | Domain | FerIin domain | FerIin domain | FerIin_dom | 6 |
IPR012969 | 12,969 | Fibrinogen binding protein | Fibrinogen_BP | Family | 307 | false | false | Proteins in this family bind to fibrinogen. Fibrinogen is capable of binding to a wide number of endogenous proteins and cell receptors during haemostasis, including binding to platelets to promote their aggregation [ ]. Included in this family is receptor FbsA ( ) from the pathogen Streptococcus agalactiae, which is r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08017"
] | [
"Fibrinogen_BP"
] | [
307
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00016552",
"PUB00017188"
] | [
"15383464",
"15837518"
] | [
"FbsA, a fibrinogen-binding protein from Streptococcus agalactiae, mediates platelet aggregation.",
"Fibrinogen and fibrin."
] | [
2005,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
40,
267
] | 2 | [] | [] | 0 | true | Family | Fibrinogen binding protein | Fibrinogen binding protein | Fibrinogen_BP | 1 |
IPR012970 | 12,970 | Polysaccharide lyase 8, N-terminal alpha-helical | Lyase_8_alpha_N | Domain | 4,417 | false | false | This α-helical domain is found in a group of secreted bacterial lyase enzymes ( ) capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08124"
] | [
"Lyase_8_N"
] | [
4417
] | 1 | [
"EC",
"METACYC"
] | [
"4.2.2.1",
"PWY-7645"
] | [
"EC:4.2.2.1",
"METACYC:PWY-7645"
] | 2 | [
"1c82",
"1cb8",
"1egu",
"1f1s",
"1f9g",
"1hm2",
"1hm3",
"1hmu",
"1hmw",
"1i8q",
"1j0m",
"1j0n",
"1loh",
"1lxk",
"1lxm",
"1n7n",
"1n7o",
"1n7p",
"1n7q",
"1n7r",
"1ojm",
"1ojn",
"1ojo",
"1ojp",
"1rw9",
"1rwa",
"1rwc",
"1rwf",
"1rwg",
"1rwh",
"1w3y",
"1x1h"... | 47 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halomicrobium mukohataei",
"Viruses",
"metagenomes"
] | [
3670,
729,
3,
3,
12
] | 5 | [] | [] | 0 | true | Domain | Polysaccharide lyase 8, N-terminal alpha-helical | Polysaccharide lyase 8, N-terminal alpha-helical | Lyase_8_alpha_N | 6 |
IPR012971 | 12,971 | Nucleolar GTP-binding protein 2, N-terminal domain | NOG2_N_dom | Domain | 4,900 | false | false | This N-terminal domain is found in Nucleolar GTP-binding protein 2 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08153"
] | [
"NGP1NT"
] | [
4900
] | 1 | [] | [] | [] | 0 | [
"3jct",
"6ft6",
"6lss",
"6lu8",
"6m62",
"6n8j",
"6ylg",
"6ylh",
"7bt6",
"7btb",
"7of1",
"7oh3",
"7ohq",
"7oht",
"7ug6",
"7uoo",
"7uqb",
"7uqz",
"7uui",
"7v08",
"8fkz",
"8fl0",
"8fl2",
"8fl3",
"8fl4",
"8fl6",
"8fl7",
"8fl9",
"8hfr",
"8idt",
"8idy",
"8ie3"... | 52 | [
"PUB00056824"
] | [
"11707418"
] | [
"Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4900
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
2,
1,
1,
2,
5,
1,
1,
3,
1,
1,
5
] | 12 | true | Domain | Nucleolar GTP-binding protein 2, N-terminal domain | Nucleolar GTP-binding protein 2, N-terminal domain | NOG2_N_dom | 8 |
IPR012972 | 12,972 | NLE | NLE | Domain | 7,968 | false | false | This domain is located N-terminal to WD40 repeats( ). It is found in the microtubule-associated protein [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08154"
] | [
"NLE"
] | [
7968
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6791226",
"R-CEL-6791226",
"R-DDI-6791226",
"R-DME-6791226",
"R-HSA-6791226",
"R-MMU-6791226",
"R-RNO-6791226",
"R-SCE-6791226",
"R-SPO-6791226",
"R-XTR-6791226"
] | [
"REACTOME:R-BTA-6791226",
"REACTOME:R-CEL-6791226",
"REACTOME:R-DDI-6791226",
"REACTOME:R-DME-6791226",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226",
"REACTOME:R-XTR-6791226"
] | 10 | [
"3jct",
"4v7f",
"4wju",
"5cxb",
"5cxc",
"5cyk",
"5dtc",
"5em2",
"5jcs",
"6elz",
"6em5",
"6ft6",
"6m62",
"6p0q",
"6qtb",
"6waj",
"6ylf",
"6ylg",
"6ylh",
"7bt6",
"7btb",
"7nac",
"7nad",
"7oh3",
"7ohq",
"7ohr",
"7oht",
"7ohv",
"7r72",
"7r7a",
"7ug6",
"7uoo"... | 60 | [
"PUB00016366"
] | [
"15112237"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7968
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
2,
3,
3,
8,
6,
1,
6,
7,
2,
2,
9
] | 12 | true | Domain | NLE | NLE | NLE | 2 |
IPR012973 | 12,973 | NOG, C-terminal | NOG_C | Domain | 4,972 | false | false | This C-terminal domain is found in the NOG subfamily of nucleolar GTP-binding proteins [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08155"
] | [
"NOGCT"
] | [
4972
] | 1 | [] | [] | [] | 0 | [
"3jct",
"4v7f",
"5jcs",
"6c0f",
"6elz",
"6em1",
"6em5",
"6ft6",
"6lss",
"6lu8",
"6m62",
"6n8j",
"6n8k",
"6n8l",
"6ylg",
"6ylh",
"6ylx",
"6yly",
"7bt6",
"7btb",
"7nac",
"7nad",
"7of1",
"7oh3",
"7ohp",
"7ohq",
"7ohr",
"7ohs",
"7oht",
"7ohu",
"7ohv",
"7ohw"... | 112 | [
"PUB00016366"
] | [
"15112237"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Gluconobacter aidae"
] | [
4971,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
1,
4,
6,
3,
1,
8,
5,
1,
1,
5
] | 12 | true | Domain | NOG, C-terminal | NOG, C-terminal | NOG_C | 7 |
IPR012974 | 12,974 | Nucleolar protein 58/56, N-terminal | NOP58/56_N | Domain | 9,470 | false | false | This N-terminal domain is found in Nucleolar protein 58/56 from fungi and animals and the homologues form plants. These are RNA-binding proteins of the NOP5 family [ ]. Nop56 and Nop58 are components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles [ , ]. This domain interacts with Nop1 and forms the box... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08156"
] | [
"NOP5NT"
] | [
9470
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6791226",
"R-DDI-4570464",
"R-DDI-6791226",
"R-HSA-390471",
"R-HSA-4570464",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-4570464",
"R-MMU-6791226",
"R-RNO-4570464",
"R-RNO-6791226",
"R-SCE-4570464",
"R-SCE-6791226",
"R-SPO-4570464",
"R-SPO-6791226"
] | [
"REACTOME:R-CEL-6791226",
"REACTOME:R-DDI-4570464",
"REACTOME:R-DDI-6791226",
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-4570464",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-4570464",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-4570464",
"REACTOME:R-RNO-6791226",
"REACTOME... | 15 | [
"5oql",
"5wlc",
"5wyj",
"5wyk",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zdt",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8"... | 50 | [
"PUB00016366",
"PUB00097816",
"PUB00097817",
"PUB00101204"
] | [
"15112237",
"12777385",
"19620283",
"28244370"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome.",
"Evidence that th... | [
2004,
2003,
2009,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9470
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
18,
2,
2,
7,
8,
8,
2,
13,
6,
2,
2,
28
] | 12 | true | Domain | Nucleolar protein 58/56, N-terminal | Nucleolar protein 58/56, N-terminal | NOP58/56_N | 8 |
IPR012975 | 12,975 | NOPS | NOPS | Domain | 4,221 | false | false | This domain is found in the DBHS (Drosophila behavior human splicing) family members. It is C-terminal to the RNA recognition motifs (RRMs). DBHS (Drosophila behavior human splicing) family are characterised by a core domain arrangement consisting of tandem RNA recognition motifs (RRMs), a conserved intervening sequenc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08075"
] | [
"NOPS"
] | [
4221
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8849468",
"R-HSA-9635465",
"R-MMU-8849468"
] | [
"REACTOME:R-HSA-8849468",
"REACTOME:R-HSA-9635465",
"REACTOME:R-MMU-8849468"
] | 3 | [
"3sde",
"4wii",
"4wij",
"4wik",
"5ca5",
"5ifm",
"5ifn",
"5wpa",
"6ncq",
"6owj",
"6wmz",
"7lrq",
"7lru",
"7pu5",
"7sp0",
"7uj1",
"7uk1",
"9glc",
"9gld",
"9gni"
] | 20 | [
"PUB00083658",
"PUB00083659"
] | [
"25832716",
"27084935"
] | [
"PSF: nuclear busy-body or nuclear facilitator?",
"The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold."
] | [
2015,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
4221
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
6,
7,
22,
14,
14
] | 6 | true | Domain | NOPS | NOPS | NOPS | 7 |
IPR012976 | 12,976 | NOSIC | NOSIC | Domain | 14,956 | false | false | This entry represents a domain centrally located in a group of pre-RNA processing ribonucleoproteins (RNPs), including the eukaryotic proteins Prp31, Nop56 and Nop58 and the archaeal homologue Nop5. This domain was named after the central domain in Nop56/SIK1-like proteins [ , ]. It is found associated with the Nop dom... | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00931"
] | [
"NOSIC"
] | [
14956
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6791226",
"R-DDI-4570464",
"R-DDI-6791226",
"R-HSA-390471",
"R-HSA-4570464",
"R-HSA-6790901",
"R-HSA-6791226",
"R-HSA-72163",
"R-MMU-4570464",
"R-MMU-6791226",
"R-MMU-72163",
"R-RNO-4570464",
"R-RNO-6791226",
"R-SCE-4570464",
"R-SCE-6791226",
"R-SPO-4570464",
"R-SPO-6791226"
] | [
"REACTOME:R-CEL-6791226",
"REACTOME:R-DDI-4570464",
"REACTOME:R-DDI-6791226",
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-4570464",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-4570464",
"REACTOME:R-MMU-6791226",
"REACTOME:R-MMU-72163",
"REACTOME:R-R... | 17 | [
"2nnw",
"2ozb",
"3icx",
"3id5",
"3id6",
"3jcm",
"3jcr",
"3nmu",
"3nvi",
"3nvk",
"3nvm",
"3pla",
"3siu",
"3siv",
"4by9",
"5gan",
"5gap",
"5gin",
"5gio",
"5gip",
"5jpq",
"5nrl",
"5o9z",
"5oql",
"5wlc",
"5wyj",
"5wyk",
"5zwm",
"5zwo",
"6ah0",
"6ahd",
"6ke6"... | 100 | [
"PUB00003706",
"PUB00016366",
"PUB00044450",
"PUB00044451",
"PUB00062921",
"PUB00090272",
"PUB00090527",
"PUB00090687",
"PUB00097816",
"PUB00097817",
"PUB00103404",
"PUB00103405",
"PUB00103406"
] | [
"9372940",
"15112237",
"11867543",
"12444105",
"11545739",
"28781166",
"28530653",
"17636026",
"12777385",
"19620283",
"33495354",
"21683323",
"22492559"
] | [
"Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis.",
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is requi... | [
1997,
2004,
2002,
2002,
2001,
2017,
2017,
2007,
2003,
2009,
2021,
2011,
2012
] | 13 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
471,
6,
14460,
19
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
33,
3,
5,
7,
14,
10,
3,
16,
11,
3,
3,
47
] | 12 | true | Domain | NOSIC | NOSIC | NOSIC | 1 |
IPR012977 | 12,977 | SDA1, N-terminal | SDA1_N | Domain | 5,097 | false | false | This entry represents the N-terminal domain of SDA1 (also referred to as NUC130/133) [ ]. It consists of HEAT repeats [ ]. Sda1 is required for 60S pre-ribosomal subunits export to the cytoplasm and may also be required for 60S ribosomal subunit maturation and accumulation. It is involved in G1 events and passage throu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08158"
] | [
"SDA1_HEAT"
] | [
5097
] | 1 | [] | [] | [] | 0 | [
"5jcs",
"6ylg",
"6ylh",
"8fl2",
"8fl3",
"8fl4",
"8idy",
"8inf",
"8ink",
"8ipy",
"8pv4",
"8pv6",
"8pv8"
] | 13 | [
"PUB00010459",
"PUB00016366",
"PUB00063829",
"PUB00063830",
"PUB00101820"
] | [
"10704371",
"15112237",
"11160833",
"14976432",
"16541108"
] | [
"The Saccharomyces cerevisiae SDA1 gene is required for actin cytoskeleton organization and cell cycle progression.",
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"The Sda1 protein is required for passage through start.",
"Expression and localization studies... | [
2000,
2004,
2001,
2004,
2006
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5097
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
1,
1,
3,
3,
1,
4,
5,
1,
1,
2
] | 12 | true | Domain | SDA1, N-terminal | SDA1, N-terminal | SDA1_N | 4 |
IPR012978 | 12,978 | RRP12, HEAT domain | HEAT_RRP12 | Domain | 5,458 | false | false | This entry represents a conserved domain found in RRP12 proteins, which consists of HEAT repeats. Ribosomal RNA-processing protein 12 (RRP12) proteins are members of pre-ribosome-associated HEAT repeats-containing proteins [ , , ]. They are involved in the maturation and nuclear export of both pre-40S and pre-60S ribos... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08161"
] | [
"RRP12_HEAT"
] | [
5458
] | 1 | [] | [] | [] | 0 | [
"7wts",
"7wtt",
"7wtu",
"7wtv",
"7wtw",
"7wtx",
"7wtz",
"7wu0"
] | 8 | [
"PUB00016366",
"PUB00101821",
"PUB00101822"
] | [
"15112237",
"14729571",
"29875412"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits.",
"Visualizing late states of human 40S ribosomal subunit maturation."
] | [
2004,
2004,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Shewanella electrica"
] | [
5457,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
14,
1,
1,
4,
3,
2,
1,
5,
4,
1,
1,
15
] | 12 | true | Domain | RRP12, HEAT domain | RRP12, HEAT domain | HEAT_RRP12 | 5 |
IPR012980 | 12,980 | PELP1, middle domain | PELP1_middle | Domain | 725 | false | false | This entry represents a middle domain found in PELP1 (Proline-, glutamic acid- and leucine-rich protein 1, also known as modulator of nongenomic activity of estrogen receptor) which consists of HEAT repeats [ ]. PELP1 is a coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormon... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08166"
] | [
"PELP1_HEAT"
] | [
725
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6791226",
"R-HSA-8849473",
"R-MMU-6791226",
"R-RNO-6791226"
] | [
"REACTOME:R-HSA-6791226",
"REACTOME:R-HSA-8849473",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226"
] | 4 | [
"7uwf",
"8fl2",
"8fl3",
"8fl4",
"9dum",
"9duo"
] | 6 | [
"PUB00016366",
"PUB00087911",
"PUB00101824",
"PUB00101826"
] | [
"15112237",
"22872859",
"14963108",
"16352611"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire.",
"Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.",
"Characterization of the interactions of estrogen recept... | [
2004,
2012,
2004,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
725
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
2,
4
] | 4 | true | Domain | PELP1, middle domain | PELP1, middle domain | PELP1_middle | 7 |
IPR012981 | 12,981 | PIH1, N-terminal | PIH1_N | Domain | 4,772 | false | false | Proteins containing this domain include kintoun, Saccharomyces cerevisiae PIH1 (protein interacting with Hsp90 1, also known as Nop17) and PIH1 domain-containing proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08190"
] | [
"PIH1"
] | [
4772
] | 1 | [] | [] | [] | 0 | [
"4chh",
"4ckt",
"4cse",
"4cv4",
"4psf",
"4psi",
"7avc",
"8bdu"
] | 8 | [
"PUB00016497",
"PUB00053568",
"PUB00061923"
] | [
"15670595",
"18268103",
"19052621"
] | [
"Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in Pre-rRNA processing.",
"Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation.",
"Ktu/PF13 is required for cytoplasmic pre-assembly of axone... | [
2005,
2008,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
4771,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
6,
2,
17,
10,
5,
1
] | 7 | true | Domain | PIH1, N-terminal | PIH1, N-terminal | PIH1_N | 2 |
IPR012983 | 12,983 | PHR | PHR | Domain | 10,236 | false | false | This domain is called PHR as it was originally found in the E3 ubiquitin-protein ligase proteins PAM ( ), highwire ( ) and RPM-1 ( ) [ ]. PHR proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptic... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08005"
] | [
"PHR"
] | [
10236
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-8951664",
"R-DRE-983168",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168"
] | [
"REACTOME:R-DRE-8951664",
"REACTOME:R-DRE-983168",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168"
] | 6 | [
"3gbw",
"3hwj",
"3no8"
] | 3 | [
"PUB00020109",
"PUB00097415"
] | [
"12878161",
"20156452"
] | [
"BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.",
"Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1."
] | [
2003,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Eukaryota",
"Staphylococcus phage Twort (strain DSM 17442 / HER 48)"
] | [
2,
10232,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
64,
5,
24,
17,
16
] | 6 | true | Domain | PHR | PHR | PHR | 2 |
IPR012985 | 12,985 | Peptidase S64, Ssy5 | Peptidase_S64_Ssy5 | Family | 323 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF08192",
"PIRSF011716"
] | [
"Peptidase_S64",
"Peptidase_S64_Ssy5"
] | [
323,
43
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000522",
"PUB00003576",
"PUB00016412"
] | [
"8439290",
"7845208",
"15509782"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases.",
"Amino acid signaling in yeast: casein kinase I and the Ssy5 endoprotease are key determinants of endoproteolytic activation of the membrane-bound Stp1 transcription factor."
] | [
1993,
1994,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta"
] | [
2,
321
] | 2 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Peptidase S64, Ssy5 | Peptidase S64, Ssy5 | Peptidase_S64_Ssy5 | 8 |
IPR012986 | 12,986 | Photosystem I PsaX | PSI_PsaX | Family | 161 | false | false | This family consists of the PsaX family of photosystem I (PSI) protein subunits. PSI is a large multi-subunit pigment protein complex embedded in the thylakoid membranes of green plants and cyanobacteria. PsaX is one of the 12 protein subunits found in PSI and these subunits are arranged as monomers or trimers within t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08078"
] | [
"PsaX"
] | [
161
] | 1 | [] | [] | [] | 0 | [
"1jb0",
"3pcq",
"4fe1",
"5zf0",
"6jeo",
"6k33",
"6k61",
"6pfy",
"6pgk",
"6pnj",
"6tcl",
"6tra",
"6trc",
"6trd",
"7bw2",
"7fix",
"7lx0",
"7m75",
"7m76",
"7m78",
"7y3f",
"8vu3",
"9eys",
"9i9l"
] | 24 | [
"PUB00016426"
] | [
"14556907"
] | [
"Photosystem I trimers from Synechocystis PCC 6803 lacking the PsaF and PsaJ subunits bind an IsiA ring of 17 units."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Cyanophyceae"
] | [
161
] | 1 | [] | [] | 0 | true | Family | Photosystem I PsaX | Photosystem I PsaX | PSI_PsaX | 8 |
IPR012987 | 12,987 | ROK, N-terminal | ROK_N | Domain | 2,289 | false | false | This presumed domain is found at the N terminus of RNP K-like proteins that also contain KH domains [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08067"
] | [
"ROKNT"
] | [
2289
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-4570464",
"R-BTA-72163",
"R-BTA-72203",
"R-HSA-4570464",
"R-HSA-72163",
"R-HSA-72203",
"R-HSA-9610379",
"R-MMU-4570464",
"R-MMU-72163",
"R-MMU-72203",
"R-RNO-4570464",
"R-RNO-72163",
"R-RNO-72203"
] | [
"REACTOME:R-BTA-4570464",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72203",
"REACTOME:R-HSA-4570464",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72203",
"REACTOME:R-HSA-9610379",
"REACTOME:R-MMU-4570464",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72203",
"REACTOME:R-RNO-4570464",
"REACTOME:R-RNO-7216... | 13 | [
"7cru"
] | 1 | [
"PUB00016366"
] | [
"15112237"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2289
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
13,
18,
8
] | 4 | true | Domain | ROK, N-terminal | ROK, N-terminal | ROK_N | 3 |
IPR012988 | 12,988 | Large ribosomal subunit protein uL30, N-terminal, eukaryota | Ribosomal_uL30_N_euk | Domain | 8,089 | false | false | This presumed domain is found at the N terminus of the large ribosomal subunit protein uL30 from eukaryotes and has been termed RL30NT or NUC018 [ ]. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08079"
] | [
"Ribosomal_L30_N"
] | [
8089
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72689",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72689",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-DDI-156827",
"R-DDI-1799339",
"R-DDI-72689",
"R-DDI-72706",
"R-DDI-97595... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-72689",
"REACTOME:R-CEL-72706",
"REACTOME:R-CEL-9759... | 69 | [
"3j6x",
"3j6y",
"3j77",
"3j78",
"3j79",
"3j7o",
"3j7p",
"3j7q",
"3j7r",
"3j92",
"3jag",
"3jah",
"3jai",
"3jaj",
"3jan",
"3jbn",
"3jbo",
"3jbp",
"3jcs",
"3jct",
"4d5y",
"4d67",
"4u3m",
"4u3n",
"4u3u",
"4u4n",
"4u4o",
"4u4q",
"4u4r",
"4u4u",
"4u4y",
"4u4z"... | 564 | [
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00016366"
] | [
"11297922",
"11290319",
"11114498",
"15112237"
] | [
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire."
] | [
2001,
2001,
2000,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
6,
8083
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
2,
2,
8,
7,
1,
10,
10,
2,
3,
25
] | 12 | true | Domain | Large ribosomal subunit protein uL30, N-terminal, eukaryota | Large ribosomal subunit protein uL30, N-terminal, eukaryota | Ribosomal_uL30_N_euk | 2 |
IPR012989 | 12,989 | SEP domain | SEP_domain | Domain | 9,207 | false | false | The SEP (after shp1, eyc and p47) domain is an eukaryotic domain, which occurs frequently and mainly in single units. Almost all proteins containing a SEP domain are succeeded closely by a UBX domain (see ). The function of the SEP domain is as yet unknown but it has been proposed to act as a reversible competitive inh... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF08059",
"PS51399",
"SM00553"
] | [
"SEP",
"SEP",
"SEP"
] | [
9046,
9114,
7566
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9013407",
"R-CEL-9013407",
"R-DDI-9013407",
"R-GGA-9013407",
"R-HSA-9013407",
"R-HSA-9696264",
"R-HSA-9696270",
"R-HSA-9696273",
"R-MMU-9013407",
"R-MMU-9696264",
"R-MMU-9696270",
"R-MMU-9696273",
"R-RNO-9013407",
"R-RNO-9696264",
"R-RNO-9696270",
"R-RNO-9696273"
] | [
"REACTOME:R-BTA-9013407",
"REACTOME:R-CEL-9013407",
"REACTOME:R-DDI-9013407",
"REACTOME:R-GGA-9013407",
"REACTOME:R-HSA-9013407",
"REACTOME:R-HSA-9696264",
"REACTOME:R-HSA-9696270",
"REACTOME:R-HSA-9696273",
"REACTOME:R-MMU-9013407",
"REACTOME:R-MMU-9696264",
"REACTOME:R-MMU-9696270",
"REACTOM... | 16 | [
"1ss6",
"1vaz",
"6opc",
"7r7s",
"7r7t",
"8ub4",
"9mpu"
] | 7 | [
"PUB00016397",
"PUB00022822"
] | [
"15498563",
"15029246"
] | [
"The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L.",
"Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97."
] | [
2004,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Haloquadratum walsbyi J07HQW2"
] | [
22,
9184,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
17,
2,
11,
4,
14,
9,
1,
7,
22,
1,
1,
17
] | 12 | true | Domain | SEP domain | SEP domain | SEP_domain | 7 |
IPR012990 | 12,990 | Sec23/Sec24, beta-sandwich | Beta-sandwich_Sec23_24 | Domain | 23,572 | false | false | COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex [ ]. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08033"
] | [
"Sec23_BS"
] | [
23572
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-204005",
"R-BTA-2132295",
"R-BTA-5694530",
"R-BTA-983170",
"R-DDI-204005",
"R-DDI-5694530",
"R-DDI-983170",
"R-DRE-204005",
"R-DRE-2132295",
"R-DRE-983170",
"R-HSA-1655829",
"R-HSA-204005",
"R-HSA-2132295",
"R-HSA-5694530",
"R-HSA-9705671",
"R-HSA-983170",
"R-MMU-204005",
"R... | [
"REACTOME:R-BTA-204005",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-5694530",
"REACTOME:R-BTA-983170",
"REACTOME:R-DDI-204005",
"REACTOME:R-DDI-5694530",
"REACTOME:R-DDI-983170",
"REACTOME:R-DRE-204005",
"REACTOME:R-DRE-2132295",
"REACTOME:R-DRE-983170",
"REACTOME:R-HSA-1655829",
"REACTOME:R-HS... | 29 | [
"1m2o",
"1m2v",
"1pcx",
"1pd0",
"1pd1",
"2nup",
"2nut",
"2qtv",
"3efo",
"3eg9",
"3egd",
"3egx",
"3eh1",
"3eh2",
"4bzi",
"5kyn",
"5kyu",
"5kyw",
"5kyx",
"5kyy",
"5vne",
"5vnf",
"5vng",
"5vnh",
"5vni",
"5vnj",
"5vnk",
"5vnl",
"5vnm",
"5vnn",
"5vno",
"6gni"... | 35 | [
"PUB00014931",
"PUB00014933"
] | [
"11535824",
"12239560"
] | [
"Structure of the Sec23p/24p and Sec13p/31p complexes of COPII.",
"Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat."
] | [
2001,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"marine sediment metagenome"
] | [
23571,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
41,
3,
25,
11,
25,
24,
3,
29,
25,
4,
4,
98
] | 12 | true | Domain | Sec23/Sec24, beta-sandwich | Sec23/Sec24, beta-sandwich | Beta-sandwich_Sec23_24 | 4 |
IPR012992 | 12,992 | Tetracycline resistance leader peptide, TetM | Tet-R_leader_TetM | Family | 187 | false | false | The antibiotic tetracycline has a broad spectrum of activity, acting to inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit, which prevents the association of the aminoacyl-tRNA to the ribosomal acceptor A site. Tetracycline binding is reversible, therefore diluting out the antibiotic can revers... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF011335",
"PF08076"
] | [
"PRK14751.1",
"TetM_leader"
] | [
178,
187
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00016597",
"PUB00035982",
"PUB00035983",
"PUB00035984",
"PUB00035985"
] | [
"1323953",
"16887689",
"15837373",
"1423217",
"15944459"
] | [
"Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation.",
"Acquired tetracycline and/or macrolide-lincosamides-streptogramin resistance in anaerobes.",
"Update on acquired tetracycline resistance genes.",
"Bacterial resistance to tetracycline: mechanisms, tr... | [
1992,
2003,
2005,
1992,
2005
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
187
] | 1 | [] | [] | 0 | true | Family | Tetracycline resistance leader peptide, TetM | Tetracycline resistance leader peptide, TetM | Tet-R_leader_TetM | 5 |
IPR012993 | 12,993 | UME domain | UME | Domain | 3,821 | false | false | This domain is characteristic of UVSB PI-3 kinase, MEI-41 and ESR1 [ ]. | [
"GO:0004674"
] | [
"protein serine/threonine kinase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF08064",
"SM00802"
] | [
"UME",
"UME"
] | [
3796,
3643
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.1",
"R-DDI-2559586",
"R-DDI-349425",
"R-DDI-5693548",
"R-DDI-5693565",
"R-DDI-6804756",
"R-DDI-6804760",
"R-DDI-9664873",
"R-DME-176187",
"R-DME-5693607",
"R-DME-6804756",
"R-DME-69473",
"R-HSA-1221632",
"R-HSA-176187",
"R-HSA-3371453",
"R-HSA-5685938",
"R-HSA-5693607",
"R-... | [
"EC:2.7.11.1",
"REACTOME:R-DDI-2559586",
"REACTOME:R-DDI-349425",
"REACTOME:R-DDI-5693548",
"REACTOME:R-DDI-5693565",
"REACTOME:R-DDI-6804756",
"REACTOME:R-DDI-6804760",
"REACTOME:R-DDI-9664873",
"REACTOME:R-DME-176187",
"REACTOME:R-DME-5693607",
"REACTOME:R-DME-6804756",
"REACTOME:R-DME-69473... | 29 | [
"5x6o",
"5yz0",
"6z2w",
"6z2x",
"6z3a",
"7wzr",
"7wzw",
"9l40",
"9l43",
"9l45",
"9l46",
"9l4b",
"9l4c",
"9l4d",
"9l4f"
] | 15 | [
"PUB00016366"
] | [
"15112237"
] | [
"Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3821
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
6,
1,
1,
2,
3,
1,
2,
2,
1,
1,
12
] | 11 | true | Domain | UME domain | UME domain | UME | 6 |
IPR012994 | 12,994 | Membrane bound YbgT-like | YbgT_YccB | Family | 4,482 | false | false | This family contains a set of membrane proteins, typically 33 amino acids long. The family has no known function, but the protein is found in the operon CydAB in Escherichia coli. Members have a consensus motif (MWYFXW), which is rich in aromatic residues. The protein forms a single membrane-spanning helix. This family... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08173"
] | [
"YbgT_YccB"
] | [
4482
] | 1 | [
"GP",
"GP",
"GP",
"GP"
] | [
"GenProp1269",
"GenProp1373",
"GenProp1515",
"GenProp1608"
] | [
"GP:GenProp1269",
"GP:GenProp1373",
"GP:GenProp1515",
"GP:GenProp1608"
] | 4 | [
"6rko",
"6rx4",
"7ose",
"7oy2"
] | 4 | [
"PUB00015302"
] | [
"9068659"
] | [
"Characterization of the tol-pal and cyd region of Escherichia coli K-12: transcript analysis and identification of two new proteins encoded by the cyd operon."
] | [
1997
] | 1 | [] | [
"IPR011724"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4462,
2,
18
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Membrane bound YbgT-like | Membrane bound YbgT-like | YbgT_YccB | 7 |
IPR012996 | 12,996 | Zinc finger, CHHC-type | Znf_CHHC | Domain | 2,236 | false | false | Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08080"
] | [
"zf-RNPHF"
] | [
2236
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-72163",
"R-BTA-72203",
"R-HSA-6803529",
"R-HSA-72163",
"R-HSA-72203",
"R-HSA-8950505",
"R-MMU-72163",
"R-MMU-72203",
"R-RNO-72163",
"R-RNO-72203"
] | [
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72203",
"REACTOME:R-HSA-6803529",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72203",
"REACTOME:R-HSA-8950505",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72203",
"REACTOME:R-RNO-72163",
"REACTOME:R-RNO-72203"
] | 10 | [
"2hgn",
"2kg1"
] | 2 | [
"PUB00014077",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812"
] | [
"12665246",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890"
] | [
"Zinc fingers--folds for many occasions.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc finger proteins: getting a grip on RNA.",
"Zinc finger peptides for the regulation of gene expression.",
"Zinc finger proteins: new ... | [
2002,
2007,
2005,
2005,
1999,
2001
] | 6 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2236
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
17,
7,
10
] | 4 | true | Domain | Zinc finger, CHHC-type | Zinc finger, CHHC-type | Znf_CHHC | 9 |
IPR012997 | 12,997 | Rare lipoprotein A | RplA | Domain | 17,174 | false | false | Rare lipoprotein A (RlpA) is an outer membrane protein that localises to the septal ring and scattered foci along the lateral wall in Escherichia coli. In Pseudomonas aeruginosa, RlpA is a lytic transglycosylase with preference for naked glycan strands that is needed for efficient separation of daughter cells and maint... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00413"
] | [
"rlpA"
] | [
17174
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"4.2.2.-",
"PWY-7246",
"PWY-7647"
] | [
"EC:4.2.2.-",
"METACYC:PWY-7246",
"METACYC:PWY-7647"
] | 3 | [
"4avr",
"8kea"
] | 2 | [
"PUB00074369"
] | [
"24806796"
] | [
"The bacterial septal ring protein RlpA is a lytic transglycosylase that contributes to rod shape and daughter cell separation in Pseudomonas aeruginosa."
] | [
2014
] | 1 | [
"IPR009009"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
16909,
56,
23,
186
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Rare lipoprotein A | Rare lipoprotein A | RplA | 7 |
IPR012999 | 12,999 | Pyridine nucleotide-disulphide oxidoreductase, class I, active site | Pyr_OxRdtase_I_AS | Active_site | 79,044 | false | false | The pyridine nucleotide-disulphide oxidoreductases are FAD flavoproteins which contain a pair of redox-active cysteines involved in the transfer of reducing equivalents from the FAD cofactor to the substrate. On the basis of sequence and structural similarities [ ] these enzymes can be classified into two categories. T... | [
"GO:0016668"
] | [
"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00076"
] | [
"PYRIDINE_REDOX_1"
] | [
79044
] | 1 | [
"EC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"1.8.1",
"PDOC00073",
"R-BTA-204174",
"R-BTA-3299685",
"R-BTA-499943",
"R-BTA-5263617",
"R-BTA-5362517",
"R-BTA-5628897",
"R-BTA-6783984",
"R-BTA-70895",
"R-BTA-9837999",
"R-BTA-9853506",
"R-BTA-9858328",
"R-BTA-9859138",
"R-BTA-9861559",
"R-CEL-204174",
"R-CEL-3299685",
"R-CEL-499... | [
"EC:1.8.1",
"PROSITEDOC:PDOC00073",
"REACTOME:R-BTA-204174",
"REACTOME:R-BTA-3299685",
"REACTOME:R-BTA-499943",
"REACTOME:R-BTA-5263617",
"REACTOME:R-BTA-5362517",
"REACTOME:R-BTA-5628897",
"REACTOME:R-BTA-6783984",
"REACTOME:R-BTA-70895",
"REACTOME:R-BTA-9837999",
"REACTOME:R-BTA-9853506",
... | 104 | [
"1aog",
"1bhy",
"1bwc",
"1bzl",
"1dnc",
"1dxl",
"1ebd",
"1fea",
"1feb",
"1fec",
"1ger",
"1ges",
"1get",
"1geu",
"1gra",
"1grb",
"1gre",
"1grf",
"1grg",
"1grh",
"1grt",
"1gsn",
"1gxf",
"1h6v",
"1jeh",
"1k4q",
"1lpf",
"1lvl",
"1nda",
"1ojt",
"1onf",
"1typ"... | 258 | [
"PUB00000149",
"PUB00001694",
"PUB00003204",
"PUB00004100",
"PUB00004526",
"PUB00005377"
] | [
"2643922",
"7589432",
"6546954",
"2067578",
"1303792",
"1957352"
] | [
"Dihydrolipoamide dehydrogenase: functional similarities and divergent evolution of the pyridine nucleotide-disulfide oxidoreductases.",
"Cloning and sequencing of a human thioredoxin reductase.",
"Structural relationship between glutathione reductase and lipoamide dehydrogenase.",
"Convergent evolution of si... | [
1989,
1995,
1984,
1991,
1992,
1991
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
1349,
59958,
16778,
2,
3,
954
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
21,
5,
9,
4,
3,
38,
25,
2,
13,
17,
2,
2,
30
] | 13 | true | Active_site | Pyridine nucleotide-disulphide oxidoreductase, class I, active site | Pyridine nucleotide-disulphide oxidoreductase, class I, active site | Pyr_OxRdtase_I_AS | 8 |
IPR013005 | 13,005 | Large ribosomal subunit protein uL4-like | Ribosomal_uL4-like | Family | 30,282 | false | false | This family includes bacterial Large ribosomal subunit protein uL4 and eukaryotic Large ribosomal subunit protein uL4c/m (also known as L4) [ ]. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This lead... | [] | [] | [] | 0 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_01328_B",
"PTHR10746",
"TIGR03953"
] | [
"Ribosomal_uL4_B",
"",
"rplD_bact"
] | [
26536,
30221,
28228
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9937383",
"R-DRE-5389840",
"R-DRE-5419276",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383"
] | [
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9937383",
"REACTOME:R-DRE-5389840",
"REACTOME:R-DRE-5419276",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOM... | 12 | [
"1dmg",
"1j5a",
"1jzx",
"1jzy",
"1jzz",
"1k01",
"1nkw",
"1nwx",
"1nwy",
"1sm1",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xbp",
"2ftc",
"2j28",
"2rdo",
"2zjp",
"2zjq",
"2zjr",
"3bbx",
"3cf5",
"3dll",
"3iy9",
"3j3v",
"3j3w",
"3j5l",
"3j6b",
"3j7y",
"3j7z"... | 1,301 | [
"PUB00000678",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00080279"
] | [
"9838082",
"11297922",
"11290319",
"11114498",
"24524803"
] | [
"Yeast ribosomal proteins L4, L17, L20, and L25 exhibit different binding characteristics for the yeast 35S precursor rRNA.",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"A new system for naming ribosoma... | [
1998,
2001,
2001,
2000,
2014
] | 5 | [
"IPR002136"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Candidatus Methanofastidiosum methylothiophilum",
"Eukaryota",
"unclassified sequences"
] | [
24111,
1,
5699,
471
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
13,
1,
2,
1,
1,
7,
5,
1,
10,
4,
1,
1,
12
] | 13 | true | Family | Large ribosomal subunit protein uL4-like | Large ribosomal subunit protein uL4-like | Ribosomal_uL4-like | 7 |
IPR013006 | 13,006 | Antimicrobial peptide, C6 type, conserved site | Antimicrobial_C6_CS | Conserved_site | 42 | false | false | Plants normally grow on substrates that are extremely rich in microorganisms, but infection remains a rare event. During evolution, plants have developed a variety of defence systems to protect themselves from potential pathogens. Proteins including thionins, plant defensins and chitinases have been shown to play activ... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS60011"
] | [
"PLANT_C6_AMP"
] | [
42
] | 1 | [
"PROSITEDOC"
] | [
"PDOC60011"
] | [
"PROSITEDOC:PDOC60011"
] | 1 | [
"1dkc",
"1q3j"
] | 2 | [
"PUB00017015",
"PUB00017016",
"PUB00017017",
"PUB00017018"
] | [
"1733929",
"10759497",
"15056889",
"8627629"
] | [
"Isolation and characterization of a novel class of plant antimicrobial peptides form Mirabilis jalapa L. seeds.",
"Purification, characterization, and molecular cloning of the gene of a seed-specific antimicrobial protein from pokeweed.",
"Purification, characterization, and sequencing of novel antimicrobial p... | [
1992,
2000,
2004,
1996
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
42
] | 1 | [] | [] | 0 | true | Conserved_site | Antimicrobial peptide, C6 type, conserved site | Antimicrobial peptide, C6 type, conserved site | Antimicrobial_C6_CS | 8 |
IPR013010 | 13,010 | Zinc finger, SIAH-type | Znf_SIAH | Domain | 14,502 | false | false | SINA/Siah family proteins represent mammalian homologs of the Drosophila SINA (seven in absentia) protein. SINA is required for R7 photoreceptor cell differentiation within the sevenless pathway [ ]. Members of this family are E3 ubiquitin ligases that regulate ubiquitination and protein degradation. Siahs are known to... | [
"GO:0008270"
] | [
"zinc ion binding"
] | [
"molecular_function"
] | 1 | [
"PROFILE"
] | [
"PS51081"
] | [
"ZF_SIAH"
] | [
14502
] | 1 | [
"EC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"PDOC51081",
"R-CEL-373752",
"R-CEL-983168",
"R-DME-373752",
"R-DME-5689880",
"R-DME-983168",
"R-DRE-1358803",
"R-DRE-373752",
"R-DRE-5689880",
"R-DRE-983168",
"R-HSA-1358803",
"R-HSA-373752",
"R-HSA-5689880",
"R-HSA-977225",
"R-HSA-983168",
"R-MMU-1358803",... | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"PROSITEDOC:PDOC51081",
"REACTOME:R-CEL-373752",
"REACTOME:R-CEL-983168",
"REACTOME:R-DME-373752",
"REACTOME:R-DME-5689880",
"REACTOME:R-DME-983168",
"REACTOME:R-DRE-1358803",
"REACTOME:R-DRE-373752",
"REACTOME:R-DRE-5689880",
"REACTOME:R-DRE-983168",
"REAC... | 22 | [
"1k2f",
"2a25",
"2an6",
"4c9z",
"4ca1",
"4i7b",
"4i7c",
"4i7d",
"4x3g",
"5h9m",
"5wzz",
"8heo",
"9g0l"
] | 13 | [
"PUB00011819",
"PUB00014077",
"PUB00017023",
"PUB00017024",
"PUB00017025",
"PUB00017026",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812"
] | [
"11742346",
"12665246",
"2146028",
"9334332",
"11752454",
"9858595",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890"
] | [
"Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.",
"Zinc fingers--folds for many occasions.",
"seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.",
"Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteaso... | [
2002,
2002,
1990,
1997,
2001,
1999,
2007,
2005,
2005,
1999,
2001
] | 11 | [] | [] | 0 | 0 | null | [
"Endozoicomonas euniceicola",
"Eukaryota"
] | [
1,
14501
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
66,
1,
8,
11,
16,
10,
55,
7,
43
] | 9 | true | Domain | Zinc finger, SIAH-type | Zinc finger, SIAH-type | Znf_SIAH | 3 |
IPR013011 | 13,011 | Phosphotransferase system, EIIB component, type 2 | PTS_EIIB_2 | Domain | 44,903 | false | false | The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [ , ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars... | [
"GO:0008982",
"GO:0009401"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE"
] | [
"PS51099"
] | [
"PTS_EIIB_TYPE_2"
] | [
44903
] | 1 | [
"EC",
"PROSITEDOC"
] | [
"2.7.1",
"PDOC00795"
] | [
"EC:2.7.1",
"PROSITEDOC:PDOC00795"
] | 2 | [
"1tvm",
"1vkr",
"1vrv",
"2few",
"2kyr",
"2m1z",
"2r48",
"2r4q",
"3czc",
"4tn5",
"5dle",
"5gqs"
] | 12 | [
"PUB00000073",
"PUB00002162",
"PUB00003612",
"PUB00017027",
"PUB00017028",
"PUB00017029",
"PUB00017030",
"PUB00017031"
] | [
"2197982",
"1537788",
"8246840",
"7815935",
"11361063",
"8784182",
"9032081",
"12662934"
] | [
"The bacterial phosphoenolpyruvate: glycose phosphotransferase system.",
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.",
"The bacterial phosp... | [
1990,
1992,
1993,
1994,
2001,
1996,
1997,
2003
] | 8 | [
"IPR003501"
] | [
"IPR003353",
"IPR029503"
] | 1 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
137,
44622,
25,
119
] | 4 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica"
] | [
11,
1
] | 2 | true | Domain | Phosphotransferase system, EIIB component, type 2 | Phosphotransferase system, EIIB component, type 2 | PTS_EIIB_2 | 5 |
IPR013012 | 13,012 | Phosphotransferase system, EIIB component, type 3 | PTS_EIIB_3 | Domain | 11,226 | false | false | The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [ , ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars... | [
"GO:0008982",
"GO:0009401"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROFILE",
"NCBIFAM"
] | [
"PS51100",
"TIGR00853"
] | [
"PTS_EIIB_TYPE_3",
"pts-lac"
] | [
11226,
2158
] | 2 | [
"EC",
"GP",
"PROSITEDOC"
] | [
"2.7.1",
"GenProp0119",
"PDOC00795"
] | [
"EC:2.7.1",
"GP:GenProp0119",
"PROSITEDOC:PDOC00795"
] | 3 | [
"1e2b",
"1h9c",
"1iib",
"2l2q",
"2wwv",
"2wy2",
"3nbm",
"4mge"
] | 8 | [
"PUB00000073",
"PUB00002162",
"PUB00003612",
"PUB00017027",
"PUB00017028",
"PUB00017029",
"PUB00017030",
"PUB00017031"
] | [
"2197982",
"1537788",
"8246840",
"7815935",
"11361063",
"8784182",
"9032081",
"12662934"
] | [
"The bacterial phosphoenolpyruvate: glycose phosphotransferase system.",
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.",
"The bacterial phosp... | [
1990,
1992,
1993,
1994,
2001,
1996,
1997,
2003
] | 8 | [
"IPR003501"
] | [
"IPR041713"
] | 1 | 1 | 0 | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
11193,
6,
27
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Phosphotransferase system, EIIB component, type 3 | Phosphotransferase system, EIIB component, type 3 | PTS_EIIB_3 | 5 |
IPR013013 | 13,013 | Phosphotransferase system, EIIC component, type 1 | PTS_EIIC_1 | Domain | 44,765 | false | false | According to sequence analyses [ , , ], the PTS EIIC domain can be divided in five groups: The PTS EIIC type 1 domain is found in the Glucose class of PTS and has an average length of about 80 amino acids. The PTS EIIC type 2 domain is found in the Mannitol class of PTS and has an average length of about 90 amino acids... | [] | [] | [] | 0 | [
"PROFILE"
] | [
"PS51103"
] | [
"PTS_EIIC_TYPE_1"
] | [
44765
] | 1 | [
"EC",
"PROSITEDOC"
] | [
"2.7.1",
"PDOC51103"
] | [
"EC:2.7.1",
"PROSITEDOC:PDOC51103"
] | 2 | [
"5iws",
"6bvg",
"8qsr",
"8qst",
"9hnp"
] | 5 | [
"PUB00000073",
"PUB00002162",
"PUB00003612",
"PUB00017027",
"PUB00017028"
] | [
"2197982",
"1537788",
"8246840",
"7815935",
"11361063"
] | [
"The bacterial phosphoenolpyruvate: glycose phosphotransferase system.",
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.",
"The bacterial phosp... | [
1990,
1992,
1993,
1994,
2001
] | 5 | [
"IPR003352"
] | [
"IPR004719"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanosarcina mazei",
"unclassified sequences"
] | [
44635,
47,
1,
82
] | 4 | [
"Escherichia coli (strain K12)"
] | [
8
] | 1 | true | Domain | Phosphotransferase system, EIIC component, type 1 | Phosphotransferase system, EIIC component, type 1 | PTS_EIIC_1 | 3 |
IPR013014 | 13,014 | Phosphotransferase system, EIIC component, type 2 | PTS_EIIC_2 | Domain | 28,740 | false | false | The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [ , ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars... | [] | [] | [] | 0 | [
"PROFILE"
] | [
"PS51104"
] | [
"PTS_EIIC_TYPE_2"
] | [
28740
] | 1 | [
"EC",
"PROSITEDOC"
] | [
"2.7.1",
"PDOC51103"
] | [
"EC:2.7.1",
"PROSITEDOC:PDOC51103"
] | 2 | [
"9u82",
"9u84",
"9u8e",
"9u8h"
] | 4 | [
"PUB00000073",
"PUB00002162",
"PUB00003612",
"PUB00017027",
"PUB00017028"
] | [
"2197982",
"1537788",
"8246840",
"7815935",
"11361063"
] | [
"The bacterial phosphoenolpyruvate: glycose phosphotransferase system.",
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.",
"The bacterial phosp... | [
1990,
1992,
1993,
1994,
2001
] | 5 | [
"IPR003352"
] | [
"IPR004718",
"IPR006327"
] | 1 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
28518,
19,
131,
72
] | 4 | [
"Escherichia coli (strain K12)"
] | [
9
] | 1 | true | Domain | Phosphotransferase system, EIIC component, type 2 | Phosphotransferase system, EIIC component, type 2 | PTS_EIIC_2 | 5 |
IPR013015 | 13,015 | Laminin IV type B | Laminin_IV_B | Domain | 5,739 | false | false | Laminin is a large molecular weight glycoprotein present only in basement membranes in almost every animal tissue. Each laminin is a heterotrimer assembled from alpha, beta and gamma chain subunits, secreted and incorporated into cell-associated extracellular matrices. The laminins can self-assemble, bind to other matr... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF21199",
"PS51116"
] | [
"LAMININ_IV_B",
"LAMININ_IVB"
] | [
5536,
5723
] | 2 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC51115",
"R-DME-373752",
"R-HSA-1474228",
"R-HSA-3000157",
"R-HSA-3000171",
"R-HSA-3000178",
"R-HSA-373760",
"R-HSA-381426",
"R-HSA-8874081",
"R-HSA-8957275",
"R-HSA-9619665",
"R-HSA-9638630",
"R-HSA-9913351",
"R-HSA-9925563"
] | [
"PROSITEDOC:PDOC51115",
"REACTOME:R-DME-373752",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-3000157",
"REACTOME:R-HSA-3000171",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-373760",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8874081",
"REACTOME:R-HSA-8957275",
"REACTOME:R-HSA-9619665",
"REACTOME:R-H... | 14 | [
"5lf2"
] | 1 | [
"PUB00012222",
"PUB00017000",
"PUB00017032"
] | [
"3182802",
"10842354",
"15363809"
] | [
"Laminin, a multidomain protein. The A chain has a unique globular domain and homology with the basement membrane proteoglycan and the laminin B chains.",
"Form and function: the laminin family of heterotrimers.",
"Assembly and tissue functions of early embryonic laminins and netrins."
] | [
1988,
2000,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Natronolimnohabitans innermongolicus JCM 12255",
"Nerine latent virus",
"ecological metagenomes"
] | [
42,
5685,
1,
9,
2
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
1,
21,
6,
9
] | 6 | true | Domain | Laminin IV type B | Laminin IV type B | Laminin_IV_B | 2 |
IPR013016 | 13,016 | Peptidase C16, coronavirus | Peptidase_C16_CoV | Domain | 7,823 | false | false | This entry contains coronavirus (CoV) cysteine endopeptidases that belong to MEROPS peptidase family C16 (subfamilies C16A and C16B, clan CA). These peptidases are involved in viral polyprotein processing, releasing NSP1, NSP2 and NSP3 proteins [ ] and they also function as deubiquitinating and deISG15ylating (interfer... | [
"GO:0008234",
"GO:0006508"
] | [
"cysteine-type peptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF08715",
"PS51124"
] | [
"CoV_peptidase",
"PEPTIDASE_C16"
] | [
7818,
7330
] | 2 | [
"EC",
"EC",
"EC",
"METACYC",
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.50",
"3.4.19.12",
"3.4.22.-",
"PWY-7375",
"PDOC51124",
"R-HSA-191859",
"R-HSA-918233",
"R-HSA-9679504",
"R-HSA-9682706",
"R-HSA-9682708",
"R-HSA-9683439",
"R-HSA-9684325",
"R-HSA-9692916",
"R-HSA-9694271",
"R-HSA-9694301",
"R-HSA-9694676",
"R-HSA-9694686",
"R-HSA-9694786",
... | [
"EC:2.7.7.50",
"EC:3.4.19.12",
"EC:3.4.22.-",
"METACYC:PWY-7375",
"PROSITEDOC:PDOC51124",
"REACTOME:R-HSA-191859",
"REACTOME:R-HSA-918233",
"REACTOME:R-HSA-9679504",
"REACTOME:R-HSA-9682706",
"REACTOME:R-HSA-9682708",
"REACTOME:R-HSA-9683439",
"REACTOME:R-HSA-9684325",
"REACTOME:R-HSA-969291... | 21 | [
"2fe8",
"3e9s",
"3mj5",
"3mp2",
"4m0w",
"4mm3",
"4ovz",
"4ow0",
"4p16",
"4pt5",
"4r3d",
"4rez",
"4rf0",
"4rf1",
"4rna",
"4wur",
"4x2z",
"4ypt",
"5bz0",
"5e6j",
"5ko3",
"5tl6",
"5tl7",
"5v69",
"5v6a",
"5w8t",
"5w8u",
"5wfi",
"5y3e",
"5y3q",
"6bi8",
"6l5t"... | 151 | [
"PUB00011622",
"PUB00017034",
"PUB00094069",
"PUB00099876",
"PUB00099884",
"PUB00099885"
] | [
"10725411",
"8396668",
"29128390",
"34580920",
"33531496",
"32726803"
] | [
"Virus-encoded proteinases and proteolytic processing in the Nidovirales.",
"Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus.",
"Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein.",
"Evolution of the SARS-CoV-2 proteome in three di... | [
2000,
1993,
2018,
2021,
2021,
2020
] | 6 | [] | [
"IPR002705"
] | 0 | 1 | 0 | [
"Coronaviridae"
] | [
7823
] | 1 | [] | [] | 0 | true | Domain | Peptidase C16, coronavirus | Peptidase C16, coronavirus | Peptidase_C16_CoV | 7 |
IPR013019 | 13,019 | MAD homology, MH1 | MAD_homology_MH1 | Domain | 14,368 | false | false | This entry represents a MAD homology 1 (MH1) domain in the N-terminal region of Smad proteins (mH1). Smad proteins are signal transducers and transcriptional comodulators of TGF-beta superfamily ligands, which regulate key cellular processes such as proliferation, differentiation, and developmental fate. Ligand binding... | [
"GO:0006355",
"GO:0005667"
] | [
"regulation of DNA-templated transcription",
"transcription regulator complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PROFILE"
] | [
"PS51075"
] | [
"MH1"
] | [
14368
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC51075",
"R-BTA-201451",
"R-BTA-5689880",
"R-BTA-8941326",
"R-CEL-1181150",
"R-CEL-1502540",
"R-CEL-201451",
"R-CEL-2173788",
"R-CEL-2173789",
"R-CEL-2173795",
"R-CEL-2173796",
"R-CEL-5689880",
"R-CEL-8941326",
"R-CEL-8941855",
"R-CEL-9617828",
"R-DME-1181150",
"R-DME-1502540",
... | [
"PROSITEDOC:PDOC51075",
"REACTOME:R-BTA-201451",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-8941326",
"REACTOME:R-CEL-1181150",
"REACTOME:R-CEL-1502540",
"REACTOME:R-CEL-201451",
"REACTOME:R-CEL-2173788",
"REACTOME:R-CEL-2173789",
"REACTOME:R-CEL-2173795",
"REACTOME:R-CEL-2173796",
"REACTOME:R-... | 99 | [
"1mhd",
"1ozj",
"3kmp",
"3qsv",
"5mey",
"5mez",
"5mf0",
"5nm9",
"5od6",
"5odg",
"5x6g",
"5x6h",
"5x6m",
"6fzs",
"6fzt",
"6h3r",
"6tbz",
"6tce",
"6zmn"
] | 19 | [
"PUB00010680",
"PUB00017053"
] | [
"11779503",
"9741623"
] | [
"Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.",
"Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling."
] | [
2001,
1998
] | 2 | [
"IPR003619"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Haloechinothrix aidingensis",
"metagenomes"
] | [
14362,
1,
5
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
26,
10,
62,
30,
40
] | 6 | true | Domain | MAD homology, MH1 | MAD homology, MH1 | MAD_homology_MH1 | 4 |
IPR013020 | 13,020 | ATP-dependent helicase Rad3/Chl1-like | Rad3/Chl1-like | Family | 12,933 | false | false | This entry includes a group of ATP-dependent helicases, including Rad3/XPD (ERCC2), Chl1/DDX11, DDX12, RTEL1 and BRIP1. Rad3/XPD is a subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3) [ , ]. DDX11/Chl1 is required for sister-chromatid cohesion [ , , ]. | [
"GO:0003678"
] | [
"DNA helicase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00604"
] | [
"rad3"
] | [
12933
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"5.6.2",
"R-BTA-113418",
"R-BTA-5696395",
"R-BTA-5696400",
"R-BTA-674695",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-6796648",
"R-BTA-72086",
"R-BTA-73762",
"R-BTA-73772",
"R-BTA-73776",
"R-BTA-73779",
"R-BTA-73863",
"R-BTA-75953",
"R-BTA-75955",
"R-BTA-76042",
"R... | [
"EC:5.6.2",
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-5696395",
"REACTOME:R-BTA-5696400",
"REACTOME:R-BTA-674695",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-6796648",
"REACTOME:R-BTA-72086",
"REACTOME:R-BTA-73762",
"REACTOME:R-BTA-73772",
"R... | 143 | [
"5fmf",
"5ivw",
"5iy6",
"5iy7",
"5iy8",
"5iy9",
"5of4",
"5oqj",
"5oqm",
"5sva",
"6gym",
"6nmi",
"6o9l",
"6o9m",
"6ro4",
"7ad8",
"7egb",
"7egc",
"7ena",
"7enc",
"7k01",
"7k04",
"7lbm",
"7m2u",
"7ml0",
"7ml1",
"7ml2",
"7ml3",
"7ml4",
"7nvr",
"7nvw",
"7nvx"... | 71 | [
"PUB00056880",
"PUB00062838",
"PUB00062839",
"PUB00062840",
"PUB00062841",
"PUB00062845"
] | [
"8631896",
"7961739",
"17611414",
"10931920",
"20137776",
"15226378"
] | [
"Reconstitution of TFIIH and requirement of its DNA helicase subunits, Rad3 and Rad25, in the incision step of nucleotide excision repair.",
"RNA polymerase transcription factor IIH holoenzyme from yeast.",
"Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by... | [
1996,
1994,
2007,
2000,
2010,
2004
] | 6 | [
"IPR045028"
] | [
"IPR001945",
"IPR030845"
] | 1 | 2 | 0 | [
"Eukaryota",
"Methanobacteriota"
] | [
12888,
45
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
22,
3,
26,
10,
22,
14,
2,
7,
16,
2,
2,
27
] | 12 | true | Family | ATP-dependent helicase Rad3/Chl1-like | ATP-dependent helicase Rad3/Chl1-like | Rad3/Chl1-like | 1 |
IPR013021 | 13,021 | Myo-inositol-1-phosphate synthase, GAPDH-like | Myo-inos-1-P_Synthase_GAPDH | Domain | 13,179 | false | false | This is a region of myo-inositol-1-phosphate synthases that is related to the glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01658"
] | [
"Inos-1-P_synth"
] | [
13179
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.5.1.4",
"PWY-2301",
"PWY-4661",
"PWY-6372",
"PWY-6580",
"PWY-6664",
"R-BTA-1855183",
"R-DDI-1855183",
"R-DME-1855183",
"R-HSA-1855183",
"R-MMU-1855183",
"R-MTU-879299",
"R-PFA-1855183",
"R-RNO-1855183",
"R-SCE-1855183"
] | [
"EC:5.5.1.4",
"METACYC:PWY-2301",
"METACYC:PWY-4661",
"METACYC:PWY-6372",
"METACYC:PWY-6580",
"METACYC:PWY-6664",
"REACTOME:R-BTA-1855183",
"REACTOME:R-DDI-1855183",
"REACTOME:R-DME-1855183",
"REACTOME:R-HSA-1855183",
"REACTOME:R-MMU-1855183",
"REACTOME:R-MTU-879299",
"REACTOME:R-PFA-1855183... | 15 | [
"1gr0",
"1jkf",
"1jki",
"1la2",
"1p1f",
"1p1h",
"1p1i",
"1p1j",
"1p1k",
"1rm0",
"1u1i",
"1vko",
"3cin",
"3qvs",
"3qvt",
"3qvw",
"3qvx",
"3qw2",
"6k96",
"7nwr",
"9f2k"
] | 21 | [
"PUB00005654",
"PUB00006393"
] | [
"7975896",
"9370339"
] | [
"Comparison of INO1 gene sequences and products in Candida albicans and Saccharomyces cerevisiae.",
"1L-myo-inositol-1-phosphate synthase."
] | [
1994,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Menderavirus",
"unclassified sequences"
] | [
615,
7263,
4977,
5,
319
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S... | [
20,
1,
1,
5,
1,
1,
3,
3,
1,
46
] | 10 | true | Domain | Myo-inositol-1-phosphate synthase, GAPDH-like | Myo-inositol-1-phosphate synthase, GAPDH-like | Myo-inos-1-P_Synthase_GAPDH | 2 |
IPR013022 | 13,022 | Xylose isomerase-like, TIM barrel domain | Xyl_isomerase-like_TIM-brl | Domain | 145,193 | false | false | This entry represents a structural motif with a β/α TIM barrel found in several proteins families: Endonuclease IV ( ), an AP (apurinic/apyrimidinic) endonuclease that primes DNA repair synthesis by cleaving the DNA backbone 5' of AP sites [ ]. L-rhamnose isomerase ( ), a tetramer of four TIM barrels that catalyses the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01261"
] | [
"AP_endonuc_2"
] | [
145193
] | 1 | [
"EC",
"GP",
"GP",
"GP"
] | [
"3.1.21",
"GenProp1271",
"GenProp1527",
"GenProp1624"
] | [
"EC:3.1.21",
"GP:GenProp1271",
"GP:GenProp1527",
"GP:GenProp1624"
] | 4 | [
"1a0e",
"1bhw",
"1bxb",
"1bxc",
"1clk",
"1did",
"1die",
"1dxi",
"1gw9",
"1i60",
"1i6n",
"1k77",
"1mnz",
"1muw",
"1o1h",
"1oad",
"1qt1",
"1qtw",
"1qum",
"1s5m",
"1s5n",
"1xib",
"1xic",
"1xid",
"1xie",
"1xif",
"1xig",
"1xih",
"1xii",
"1xij",
"1xim",
"1xin"... | 351 | [
"PUB00017986",
"PUB00035702",
"PUB00035703",
"PUB00035704"
] | [
"10458614",
"17141803",
"16673077",
"7007313"
] | [
"Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis.",
"The structures of L-rhamnose isomerase from Pseudomonas stutzeri in complexes with L-rhamnose and D-allose provide insights into broad substrate specificity.",
"A... | [
1999,
2007,
2006,
1981
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3229,
131535,
8129,
108,
2192
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (stra... | [
1,
2,
7,
1,
9,
10,
1,
3,
5,
1,
1
] | 11 | true | Domain | Xylose isomerase-like, TIM barrel domain | Xylose isomerase-like, TIM barrel domain | Xyl_isomerase-like_TIM-brl | 6 |
IPR013023 | 13,023 | Ketol-acid reductoisomerase | KARI | Family | 26,931 | false | false | Ketol-acid reductoisomerase (KARI) or acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine [ ]. The enzyme forms a tetramer of similar but no... | [
"GO:0016491",
"GO:0009082"
] | [
"oxidoreductase activity",
"branched-chain amino acid biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_00435",
"PTHR21371",
"TIGR00465"
] | [
"IlvC",
"",
"ilvC"
] | [
20750,
26919,
24560
] | 3 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC"
] | [
"1.1.1",
"1.1.1.86",
"GenProp0162",
"GenProp0163",
"GenProp0164",
"GenProp1342",
"GenProp1748",
"PWY-5103",
"PWY-7111"
] | [
"EC:1.1.1",
"EC:1.1.1.86",
"GP:GenProp0162",
"GP:GenProp0163",
"GP:GenProp0164",
"GP:GenProp1342",
"GP:GenProp1748",
"METACYC:PWY-5103",
"METACYC:PWY-7111"
] | 9 | [
"1np3",
"1qmg",
"1yrl",
"1yve",
"3fr7",
"3fr8",
"3ulk",
"4kqw",
"4kqx",
"4tsk",
"4xdy",
"4xdz",
"4xeh",
"4xiy",
"4ypo",
"5e4r",
"5w3k",
"5yeq",
"6aqj",
"6bul",
"6c55",
"6c5n",
"6jcv",
"6jcw",
"6jcz",
"6jd1",
"6jd2",
"6jx2",
"6kou",
"6kpa",
"6kpe",
"6kph"... | 75 | [
"PUB00001302",
"PUB00084182"
] | [
"9218783",
"25172159"
] | [
"The crystal structure of plant acetohydroxy acid isomeroreductase complexed with NADPH, two magnesium ions and a herbicidal transition state analog determined at 1.65 A resolution.",
"Uncovering rare NADH-preferring ketol-acid reductoisomerases."
] | [
1997,
2014
] | 2 | [] | [
"IPR014359",
"IPR016206",
"IPR016207"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Imitervirales",
"unclassified sequences"
] | [
875,
22002,
3473,
3,
578
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
4,
1,
1,
11,
1,
1,
16
] | 7 | true | Family | Ketol-acid reductoisomerase | Ketol-acid reductoisomerase | KARI | 9 |
IPR013024 | 13,024 | Gamma-glutamyl cyclotransferase-like | GGCT-like | Domain | 40,214 | false | false | Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24 [ ]. The enzyme participates in the gamma-glutamyl cycle, which plays a pre-eminent role in ... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd06661"
] | [
"GGCT_like"
] | [
40214
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-174403",
"R-DRE-174403",
"R-HSA-174403",
"R-HSA-9648895",
"R-MMU-174403",
"R-RNO-174403",
"R-SCE-174403",
"R-SPO-174403"
] | [
"REACTOME:R-BTA-174403",
"REACTOME:R-DRE-174403",
"REACTOME:R-HSA-174403",
"REACTOME:R-HSA-9648895",
"REACTOME:R-MMU-174403",
"REACTOME:R-RNO-174403",
"REACTOME:R-SCE-174403",
"REACTOME:R-SPO-174403"
] | 8 | [
"1v30",
"1vkb",
"1xhs",
"2g0q",
"2i5t",
"2jqv",
"2kl2",
"2pn7",
"2q53",
"2qik",
"2rbh",
"3cry",
"3jub",
"3juc",
"3jud",
"5hwi",
"5hwk",
"6k95",
"6ky0",
"6ky1"
] | 20 | [
"PUB00007984",
"PUB00008105",
"PUB00035714",
"PUB00040892",
"PUB00043815",
"PUB00080684",
"PUB00080929"
] | [
"8742710",
"10203839",
"17462573",
"16754964",
"18515354",
"23070364",
"6137189"
] | [
"Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes.",
"Bacterial tellurite resistance.",
"Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain.",
"Solution structure of Arabidopsis thaliana ... | [
1996,
1999,
2007,
2006,
2008,
2012,
1983
] | 7 | [] | [
"IPR009288"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
394,
21701,
17729,
108,
282
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
50,
4,
13,
10,
2,
9,
9,
2,
16,
15,
1,
1,
38
] | 13 | true | Domain | Gamma-glutamyl cyclotransferase-like | Gamma-glutamyl cyclotransferase-like | GGCT-like | 9 |
IPR013025 | 13,025 | Large ribosomal subunit protein uL23-like | Ribosomal_uL23-like | Family | 49,992 | false | false | This entry represents the large ribosomal subunit protein uL23, previously known as L25 in yeast and L23 in bacteria, archaea and some eukaryotes [ ]. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. Thi... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"HAMAP",
"PFAM",
"PANTHER",
"PANTHER"
] | [
"MF_01369_A",
"MF_01369_B",
"PF00276",
"PTHR11620",
"PTHR12059"
] | [
"Ribosomal_uL23_A",
"Ribosomal_uL23_B",
"Ribosomal_L23",
"",
""
] | [
6835,
36798,
48941,
42912,
4588
] | 5 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-5389840",
"R-CEL-5419276",
"R-CEL-72689",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-CEL-9937383",
"R-DDI-156827",
"R-DDI-1799339",
"R-DDI-72689",
"R-DDI-72706",
"R-DDI-975956",
"R-DDI-975957",
"R-DME-5389840",
"R-DME-5419276",
"R-DME-... | [
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-5389840",
"REACTOME:R-CEL-5419276",
"REACTOME:R-CEL-72689",
"REACTOME:R-CEL-72706",
"REACTOME:R-CEL-975956",
"REACTOME:R-CEL-975957",
"REACTOME:R-CEL-9937383",
"REACTOME:R-DDI-156827",
"REACTOME:R-DDI-1799339",
"REACTOME:R-DDI-... | 62 | [
"1ffk",
"1jj2",
"1k73",
"1k8a",
"1k9m",
"1kc8",
"1kd1",
"1kqs",
"1m1k",
"1m90",
"1ml5",
"1n88",
"1n8r",
"1nji",
"1nkw",
"1nwx",
"1nwy",
"1q7y",
"1q81",
"1q82",
"1q86",
"1qvf",
"1qvg",
"1s72",
"1sm1",
"1vq4",
"1vq5",
"1vq6",
"1vq7",
"1vq8",
"1vq9",
"1vqk"... | 1,943 | [
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00080279"
] | [
"11297922",
"11290319",
"11114498",
"24524803"
] | [
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"A new system for naming ribosomal proteins."
] | [
2001,
2001,
2000,
2014
] | 4 | [] | [
"IPR019985"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
911,
23393,
25237,
451
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
17,
3,
4,
6,
1,
16,
7,
2,
11,
24,
2,
3,
46
] | 13 | true | Family | Large ribosomal subunit protein uL23-like | Large ribosomal subunit protein uL23-like | Ribosomal_uL23-like | 1 |
IPR013029 | 13,029 | YchF, C-terminal domain | YchF_C | Domain | 32,320 | false | false | This domain is found at the C terminus of YchF. The crystal structure of YchF from Haemophilus influenzae has been determined [ ]. This protein consists of three domains: an N-terminal domain which has a mononucleotide binding fold typical for the P-loop NTPases, a central domain which forms an α-helical coiled coil, a... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF06071",
"cd04867"
] | [
"YchF-GTPase_C",
"TGS_YchF_OLA1"
] | [
32318,
29453
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-114608",
"R-CEL-114608",
"R-DME-114608",
"R-DRE-114608",
"R-GGA-114608",
"R-HSA-114608",
"R-MMU-114608",
"R-RNO-114608",
"R-SCE-114608",
"R-SPO-114608",
"R-XTR-114608"
] | [
"REACTOME:R-BTA-114608",
"REACTOME:R-CEL-114608",
"REACTOME:R-DME-114608",
"REACTOME:R-DRE-114608",
"REACTOME:R-GGA-114608",
"REACTOME:R-HSA-114608",
"REACTOME:R-MMU-114608",
"REACTOME:R-RNO-114608",
"REACTOME:R-SCE-114608",
"REACTOME:R-SPO-114608",
"REACTOME:R-XTR-114608"
] | 11 | [
"1jal",
"1ni3",
"2dby",
"2dwq",
"2ohf",
"5ee0",
"5ee1",
"5ee3",
"5ee9",
"7y9i",
"8kie",
"8w51"
] | 12 | [
"PUB00016351"
] | [
"12837776"
] | [
"Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
25092,
6655,
2,
571
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
1,
3,
4,
1,
3,
5,
1,
4,
7,
2,
2,
16
] | 13 | true | Domain | YchF, C-terminal domain | YchF, C-terminal domain | YchF_C | 4 |
IPR013030 | 13,030 | DNA topoisomerase I, DNA binding, N-terminal domain 2 | DNA_topo_DNA_db_N_dom2 | Homologous_superfamily | 9,292 | false | false | DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi... | [
"GO:0003677",
"GO:0003917",
"GO:0006265",
"GO:0005694"
] | [
"DNA binding",
"DNA topoisomerase type I (single strand cut, ATP-independent) activity",
"DNA topological change",
"chromosome"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"CATHGENE3D"
] | [
"G3DSA:2.170.11.10"
] | [
""
] | [
9292
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.6.2.1",
"R-CEL-4615885",
"R-DDI-4615885",
"R-HSA-4615885",
"R-MMU-4615885",
"R-RNO-4615885",
"R-SCE-4615885",
"R-SPO-4615885"
] | [
"EC:5.6.2.1",
"REACTOME:R-CEL-4615885",
"REACTOME:R-DDI-4615885",
"REACTOME:R-HSA-4615885",
"REACTOME:R-MMU-4615885",
"REACTOME:R-RNO-4615885",
"REACTOME:R-SCE-4615885",
"REACTOME:R-SPO-4615885"
] | 8 | [
"1a31",
"1a35",
"1a36",
"1ej9",
"1k4s",
"1k4t",
"1lpq",
"1nh3",
"1ois",
"1r49",
"1rr8",
"1rrj",
"1sc7",
"1seu",
"1t8i",
"1tl8",
"2b9s",
"6z01",
"6z03"
] | 19 | [
"PUB00005230",
"PUB00005437",
"PUB00016842",
"PUB00020793",
"PUB00020794",
"PUB00020800",
"PUB00081702",
"PUB00081703",
"PUB00081704",
"PUB00081705"
] | [
"9488644",
"7770916",
"11395412",
"12596227",
"12042765",
"14741206",
"21087076",
"20644584",
"17722649",
"17293019"
] | [
"Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.",
"The mechanisms of DNA topoisomerases.",
"DNA topoisomerases: structure, function, and mechanism.",
"Phylogenomics of type II DNA topoisomerases.",
"Cellular roles of DNA topoisomerases: a molecular perspective.",... | [
1998,
1995,
2001,
2003,
2002,
2004,
2010,
2010,
2007,
2007
] | 10 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"Megaviricetes",
"metagenomes"
] | [
95,
9137,
36,
24
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
7,
7,
14,
3,
2,
2,
10,
1,
1,
18
] | 12 | true | Homologous_superfamily | DNA topoisomerase I, DNA binding, N-terminal domain 2 | DNA topoisomerase I, DNA binding, N-terminal domain 2 | DNA_topo_DNA_db_N_dom2 | 3 |
IPR013032 | 13,032 | EGF-like, conserved site | EGF-like_CS | Conserved_site | 50,820 | false | false | This entry represents a conserved site in the EGF-like domain. A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown [ , , , ] to be present, in a more or less conserved form, in a large number of other, mostly animal proteins. The list of pro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12661"
] | [
"hEGF"
] | [
50820
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"PDOC00021",
"R-BTA-1474228",
"R-BTA-1566948",
"R-BTA-2129379",
"R-BTA-216083",
"R-BTA-2173789",
"R-BTA-381426",
"R-BTA-8957275",
"R-CEL-1912420",
"R-CEL-376176",
"R-CEL-9010553",
"R-CEL-9013700",
"R-CEL-9604323",
"R-DME-1912420",
"R-DME-2979096",
"R-DME-376176",
"R-DME-428890",
"R... | [
"PROSITEDOC:PDOC00021",
"REACTOME:R-BTA-1474228",
"REACTOME:R-BTA-1566948",
"REACTOME:R-BTA-2129379",
"REACTOME:R-BTA-216083",
"REACTOME:R-BTA-2173789",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-8957275",
"REACTOME:R-CEL-1912420",
"REACTOME:R-CEL-376176",
"REACTOME:R-CEL-9010553",
"REACTOME:R-C... | 122 | [
"1aut",
"2ygq",
"4xbm",
"5ky0",
"5ky4",
"5ky8",
"5ky9",
"5uk5",
"6pog",
"9b3n"
] | 10 | [
"PUB00001555",
"PUB00003983",
"PUB00004321",
"PUB00004609"
] | [
"3282918",
"6607417",
"2288911",
"6334307"
] | [
"Structure and function of epidermal growth factor-like regions in proteins.",
"Computer-based characterization of epidermal growth factor precursor.",
"The many faces of epidermal growth factor repeats.",
"Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth ... | [
1988,
1984,
1990,
1984
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
33,
50787
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
183,
30,
142,
91,
146
] | 6 | true | Conserved_site | EGF-like, conserved site | EGF-like, conserved site | EGF-like_CS | 5 |
IPR013033 | 13,033 | Septum formation inhibitor MinC | MinC | Family | 11,243 | false | false | In Escherichia coli FtsZ ( ) assembles into a Z ring at midcell. Its assembly at polar sites is prevented by the min system. MinC , a component of this system, is an inhibitor of FtsZ assembly that is positioned within the cell by interaction with the MinDE proteins. MinC is an oligomer, probably a dimer [ ]. The C-ter... | [
"GO:0051726",
"GO:1901891"
] | [
"regulation of cell cycle",
"regulation of cell septum assembly"
] | [
"biological_process",
"biological_process"
] | 2 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_00267",
"PTHR34108",
"TIGR01222"
] | [
"MinC",
"",
"minC"
] | [
10484,
11238,
9226
] | 3 | [
"GP"
] | [
"GenProp0165"
] | [
"GP:GenProp0165"
] | 1 | [
"1hf2",
"3ghf",
"4l1c",
"4v02",
"5xdm",
"6riq"
] | 6 | [
"PUB00008426"
] | [
"10869074"
] | [
"Analysis of MinC reveals two independent domains involved in interaction with MinD and FtsZ."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
11009,
160,
74
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Septum formation inhibitor MinC | Septum formation inhibitor MinC | MinC | 5 |
IPR013034 | 13,034 | DNA topoisomerase I, DNA binding, N-terminal domain 1 | DNA_topo_DNA_db_N_dom1 | Homologous_superfamily | 9,054 | false | false | DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi... | [
"GO:0003917",
"GO:0006265"
] | [
"DNA topoisomerase type I (single strand cut, ATP-independent) activity",
"DNA topological change"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.10.41"
] | [
""
] | [
9054
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.6.2.1",
"R-CEL-4615885",
"R-DDI-4615885",
"R-HSA-4615885",
"R-MMU-4615885",
"R-RNO-4615885",
"R-SCE-4615885",
"R-SPO-4615885"
] | [
"EC:5.6.2.1",
"REACTOME:R-CEL-4615885",
"REACTOME:R-DDI-4615885",
"REACTOME:R-HSA-4615885",
"REACTOME:R-MMU-4615885",
"REACTOME:R-RNO-4615885",
"REACTOME:R-SCE-4615885",
"REACTOME:R-SPO-4615885"
] | 8 | [
"1a31",
"1a35",
"1a36",
"1ej9",
"1k4s",
"1k4t",
"1lpq",
"1nh3",
"1ois",
"1r49",
"1rr8",
"1rrj",
"1sc7",
"1seu",
"1t8i",
"1tl8",
"2b9s",
"6z01",
"6z03"
] | 19 | [
"PUB00005230",
"PUB00005437",
"PUB00016842",
"PUB00020793",
"PUB00020794",
"PUB00020800",
"PUB00081702",
"PUB00081703",
"PUB00081704",
"PUB00081705"
] | [
"9488644",
"7770916",
"11395412",
"12596227",
"12042765",
"14741206",
"21087076",
"20644584",
"17722649",
"17293019"
] | [
"Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.",
"The mechanisms of DNA topoisomerases.",
"DNA topoisomerases: structure, function, and mechanism.",
"Phylogenomics of type II DNA topoisomerases.",
"Cellular roles of DNA topoisomerases: a molecular perspective.",... | [
1998,
1995,
2001,
2003,
2002,
2004,
2010,
2010,
2007,
2007
] | 10 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"Megaviricetes",
"metagenomes"
] | [
94,
8902,
34,
24
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
1,
6,
7,
18,
4,
2,
2,
10,
1,
1,
15
] | 12 | true | Homologous_superfamily | DNA topoisomerase I, DNA binding, N-terminal domain 1 | DNA topoisomerase I, DNA binding, N-terminal domain 1 | DNA_topo_DNA_db_N_dom1 | 8 |
IPR013035 | 13,035 | Phosphoenolpyruvate carboxykinase, C-terminal | PEP_carboxykinase_C | Homologous_superfamily | 33,058 | false | false | Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the first committed (rate-limiting) step in hepatic gluconeogenesis, namely the reversible decarboxylation of oxaloacetate to phosphoenolpyruvate (PEP) and carbon dioxide, using either ATP or GTP as a source of phosphate. The ATP-utilising ( ) and GTP-utilising ( ) en... | [
"GO:0004611",
"GO:0017076",
"GO:0006094"
] | [
"phosphoenolpyruvate carboxykinase activity",
"purine nucleotide binding",
"gluconeogenesis"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"CATHGENE3D"
] | [
"G3DSA:3.90.228.20"
] | [
""
] | [
33058
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.1.1.49",
"PWY-561",
"PWY-7117",
"R-DDI-70263",
"R-DME-70263",
"R-GGA-352875",
"R-HSA-2161541",
"R-HSA-381340",
"R-HSA-70263",
"R-HSA-9615017",
"R-HSA-9632974",
"R-MMU-70263",
"R-RNO-70263",
"R-SSC-70263"
] | [
"EC:4.1.1.49",
"METACYC:PWY-561",
"METACYC:PWY-7117",
"REACTOME:R-DDI-70263",
"REACTOME:R-DME-70263",
"REACTOME:R-GGA-352875",
"REACTOME:R-HSA-2161541",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-70263",
"REACTOME:R-HSA-9615017",
"REACTOME:R-HSA-9632974",
"REACTOME:R-MMU-70263",
"REACTOME:R-RN... | 14 | [
"1aq2",
"1ayl",
"1ii2",
"1j3b",
"1k3c",
"1k3d",
"1khb",
"1khe",
"1khf",
"1khg",
"1m51",
"1nhx",
"1oen",
"1os1",
"1xkv",
"1ygg",
"1ylh",
"1ytm",
"1yvy",
"2faf",
"2fah",
"2gmv",
"2olq",
"2olr",
"2pc9",
"2pxz",
"2py7",
"2qew",
"2qey",
"2qf1",
"2qf2",
"2qzy"... | 115 | [
"PUB00003355",
"PUB00035740",
"PUB00035741",
"PUB00035742",
"PUB00035743",
"PUB00035744"
] | [
"8609605",
"16330239",
"15023367",
"15890557",
"17403375",
"16126724"
] | [
"Crystal structure of Escherichia coli phosphoenolpyruvate carboxykinase: a new structural family with the P-loop nucleoside triphosphate hydrolase fold.",
"Nucleotide specificity of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase Kinetics, fluorescence spectroscopy, and molecular simulation studies.",... | [
1996,
2006,
2004,
2005,
2007,
2005
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
369,
20523,
11613,
9,
544
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
13,
6,
2,
4,
1,
11,
13,
1,
15,
11,
1,
29
] | 12 | true | Homologous_superfamily | Phosphoenolpyruvate carboxykinase, C-terminal | Phosphoenolpyruvate carboxykinase, C-terminal | PEP_carboxykinase_C | 2 |
IPR013036 | 13,036 | Domain of unknown function DUF1587 | DUF1587 | Domain | 2,675 | false | false | A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also contain domains , , and . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07626"
] | [
"PSD3"
] | [
2675
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2498,
6,
171
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF1587 | Domain of unknown function DUF1587 | DUF1587 | 2 |
IPR013037 | 13,037 | Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain | Clathrin_b-adaptin_app_Ig-like | Homologous_superfamily | 5,705 | false | false | Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. These vesicles have specific coat proteins (such as clathrin or coatomer) that are ... | [
"GO:0006886",
"GO:0016192"
] | [
"intracellular protein transport",
"vesicle-mediated transport"
] | [
"biological_process",
"biological_process"
] | 2 | [
"CATHGENE3D"
] | [
"G3DSA:2.60.40.1150"
] | [
""
] | [
5705
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-177504",
"R-BTA-2132295",
"R-BTA-416993",
"R-BTA-437239",
"R-BTA-5099900",
"R-BTA-5140745",
"R-BTA-8856825",
"R-BTA-8856828",
"R-BTA-8866427",
"R-BTA-8964038",
"R-DDI-432720",
"R-DDI-437239",
"R-DDI-8856825",
"R-DDI-8856828",
"R-DDI-8866427",
"R-DDI-8964038",
"R-HSA-164940",
... | [
"REACTOME:R-BTA-177504",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-416993",
"REACTOME:R-BTA-437239",
"REACTOME:R-BTA-5099900",
"REACTOME:R-BTA-5140745",
"REACTOME:R-BTA-8856825",
"REACTOME:R-BTA-8856828",
"REACTOME:R-BTA-8866427",
"REACTOME:R-BTA-8964038",
"REACTOME:R-DDI-432720",
"REACTOME:R-... | 57 | [
"1e42",
"2g30",
"2iv8",
"2iv9",
"3h1z",
"3hs9",
"6yaf",
"6yah",
"6yai",
"7om8",
"7ux3",
"8d4c",
"8d4d",
"8d4e",
"8d4f",
"8d4g",
"8d9r",
"8d9s",
"8d9t",
"8d9u",
"8d9v",
"8d9w"
] | 22 | [
"PUB00010644",
"PUB00011792",
"PUB00011809",
"PUB00011810",
"PUB00014196",
"PUB00027621",
"PUB00035753",
"PUB00035754",
"PUB00035755",
"PUB00035756",
"PUB00035757",
"PUB00035765",
"PUB00035769"
] | [
"11080148",
"12176391",
"10702286",
"12042876",
"14708007",
"12808037",
"17449236",
"15107467",
"12952931",
"16542748",
"17254016",
"11598180",
"15261670"
] | [
"Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation.",
"Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin.",
"Vear, a novel Golgi-associated protein with VHS and gamma-adaptin \"ear\" domains.",
"Structural basis for t... | [
2000,
2002,
2000,
2002,
2004,
2003,
2007,
2004,
2003,
2006,
2007,
2001,
2004
] | 13 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5705
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
1,
18,
2,
15,
11,
7,
15,
16
] | 9 | true | Homologous_superfamily | Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain | Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain | Clathrin_b-adaptin_app_Ig-like | 4 |
IPR013039 | 13,039 | Domain of unknown function DUF1588 | DUF1588 | Domain | 3,193 | false | false | A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also contain domains , , and . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07627"
] | [
"PSCyt3"
] | [
3193
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
3049,
5,
139
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF1588 | Domain of unknown function DUF1588 | DUF1588 | 7 |
IPR013041 | 13,041 | Clathrin adaptor, appendage, Ig-like subdomain superfamily | Clathrin_app_Ig-like_sf | Homologous_superfamily | 33,360 | false | false | Proteins synthesized on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. This traffic is bidirectional, to ensure that proteins required to form vesicles ar... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF49348"
] | [
""
] | [
33360
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-177504",
"R-BTA-2132295",
"R-BTA-416993",
"R-BTA-437239",
"R-BTA-5099900",
"R-BTA-5140745",
"R-BTA-6798695",
"R-BTA-6807878",
"R-BTA-6811434",
"R-BTA-8856825",
"R-BTA-8856828",
"R-BTA-8866427",
"R-BTA-8964038",
"R-CEL-6807878",
"R-CEL-6811434",
"R-DDI-432720",
"R-DDI-437239",
... | [
"REACTOME:R-BTA-177504",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-416993",
"REACTOME:R-BTA-437239",
"REACTOME:R-BTA-5099900",
"REACTOME:R-BTA-5140745",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-6807878",
"REACTOME:R-BTA-6811434",
"REACTOME:R-BTA-8856825",
"REACTOME:R-BTA-8856828",
"REACTOME:R... | 114 | [
"1b9k",
"1e42",
"1gyu",
"1gyv",
"1gyw",
"1iu1",
"1ky6",
"1ky7",
"1kyd",
"1kyf",
"1kyu",
"1na8",
"1om9",
"1p4u",
"1pzd",
"1qtp",
"1qts",
"1r4x",
"1w80",
"2a7b",
"2dwx",
"2dwy",
"2e9g",
"2g30",
"2iv8",
"2iv9",
"2vj0",
"2ymt",
"3h1z",
"3hs8",
"3hs9",
"3mnm"... | 66 | [
"PUB00011810",
"PUB00027621",
"PUB00029720",
"PUB00030054",
"PUB00030524",
"PUB00035753",
"PUB00035768",
"PUB00035769"
] | [
"12042876",
"12808037",
"12858162",
"14527408",
"14690497",
"17449236",
"17041781",
"15261670"
] | [
"Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.",
"Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin.",
"Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3.",
"Conserved structural motifs in intracellula... | [
2002,
2003,
2003,
2003,
2004,
2007,
2006,
2004
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Metallosphaera tengchongensis",
"marine sediment metagenome"
] | [
44,
33314,
1,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
32,
7,
50,
13,
67,
37,
4,
18,
68,
6,
6,
147
] | 12 | true | Homologous_superfamily | Clathrin adaptor, appendage, Ig-like subdomain superfamily | Clathrin adaptor, appendage, Ig-like subdomain superfamily | Clathrin_app_Ig-like_sf | 5 |
IPR013042 | 13,042 | Domain of unknown function DUF1592 | DUF1592 | Domain | 3,144 | false | false | A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also contain , , and . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07631"
] | [
"PSD4"
] | [
3144
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Marine Group I thaumarchaeote",
"unclassified sequences"
] | [
2990,
6,
1,
147
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF1592 | Domain of unknown function DUF1592 | DUF1592 | 4 |
IPR013043 | 13,043 | Domain of unknown function DUF1595 | DUF1595 | Domain | 2,698 | false | false | A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also contain , , and . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07637"
] | [
"PSD5"
] | [
2698
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2568,
6,
124
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF1595 | Domain of unknown function DUF1595 | DUF1595 | 5 |
IPR013044 | 13,044 | Domain of unknown function DUF1548 | DUF1548 | Domain | 38 | false | false | This domain is found in a small number of Chlamydia proteins of unknown function. It occurs together with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07579"
] | [
"DUF1548"
] | [
38
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chlamydia"
] | [
38
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF1548 | Domain of unknown function DUF1548 | DUF1548 | 2 |
IPR013046 | 13,046 | Phage baseplate assembly protein V/Gp45 | GpV/Gp45 | Family | 6,910 | false | false | This entry represents a family of phage (and bacteriocin) proteins related to the phage P2 V gene product (GpV), which forms the small spikes on the baseplate that bind to the host cell and penetrate through the host membrane [ ]. This entry also includes Gp45, which is a component of the baseplate that forms a central... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01644"
] | [
"phage_P2_V"
] | [
6910
] | 1 | [
"GP"
] | [
"GenProp0208"
] | [
"GP:GenProp0208"
] | 1 | [
"3aqj",
"3qr7",
"3qr8",
"3vtn",
"3vto",
"4s36",
"4s37",
"8vol",
"8vom",
"8von",
"9ki1"
] | 11 | [
"PUB00061271",
"PUB00065189",
"PUB00077063"
] | [
"21821878",
"22922659",
"20478417"
] | [
"The host-binding domain of the P2 phage tail spike reveals a trimeric iron-binding structure.",
"Crystal structure of the C-terminal domain of Mu phage central spike and functions of bound calcium ion.",
"The C-terminal domain is sufficient for host-binding activity of the Mu phage tail-spike protein."
] | [
2011,
2013,
2010
] | 3 | [] | [
"IPR014462"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
6699,
19,
177,
15
] | 4 | [] | [] | 0 | true | Family | Phage baseplate assembly protein V/Gp45 | Phage baseplate assembly protein V/Gp45 | GpV/Gp45 | 1 |
IPR013048 | 13,048 | Meiotic recombination, Spo11 | Meiotic_Spo11 | Family | 2,584 | false | false | Spo11 is a meiosis-specific protein that is responsible for the initiation of recombination during the early stages of meiosis through the formation of DNA double-strand breaks (DSBs) by a type II DNA topoisomerase-like activity [ , ]. These DSBs initiate homologous recombination, which is required for chromosomal segr... | [
"GO:0003677",
"GO:0003918",
"GO:0042138"
] | [
"DNA binding",
"DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity",
"meiotic DNA double-strand break formation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR01551"
] | [
"SPO11HOMOLOG"
] | [
2584
] | 1 | [
"EC",
"REACTOME"
] | [
"5.6.2.2",
"R-HSA-912446"
] | [
"EC:5.6.2.2",
"REACTOME:R-HSA-912446"
] | 2 | [] | 0 | [
"PUB00007203",
"PUB00007204",
"PUB00020805",
"PUB00083725"
] | [
"10534401",
"10622720",
"11805049",
"26917763"
] | [
"Cloning, characterization, and localization of mouse and human SPO11.",
"Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis.",
"Functional interactions between SPO11 and REC102 during initiation of meiotic recombination in Saccharomyces cerevisiae.",
"A DNA topoisomerase VI-like co... | [
1999,
1999,
2002,
2016
] | 4 | [
"IPR002815"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"marine sediment metagenome"
] | [
2582,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
2,
4,
4,
2,
1,
5,
6
] | 8 | true | Family | Meiotic recombination, Spo11 | Meiotic recombination, Spo11 | Meiotic_Spo11 | 9 |
IPR013055 | 13,055 | Tachykinin/Neurokinin-like, conserved site | Tachy_Neuro_lke_CS | Conserved_site | 2,592 | false | false | Tachykinins [ , , ] are a group of biologically active peptides which excite neurons, evoke behavioral responses, are potent vasodilatators and contract (directly or indirectly) many smooth muscles. This family includes many other peptides. Tachykinins, like most other active peptides, are synthesized as larger protein... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00267"
] | [
"TACHYKININ"
] | [
2592
] | 1 | [
"PROSITEDOC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"PDOC00240",
"R-BTA-380095",
"R-BTA-416476",
"R-HSA-380095",
"R-HSA-416476",
"R-MMU-380095",
"R-MMU-416476",
"R-RNO-380095",
"R-RNO-416476",
"R-SSC-380095",
"R-SSC-416476"
] | [
"PROSITEDOC:PDOC00240",
"REACTOME:R-BTA-380095",
"REACTOME:R-BTA-416476",
"REACTOME:R-HSA-380095",
"REACTOME:R-HSA-416476",
"REACTOME:R-MMU-380095",
"REACTOME:R-MMU-416476",
"REACTOME:R-RNO-380095",
"REACTOME:R-RNO-416476",
"REACTOME:R-SSC-380095",
"REACTOME:R-SSC-416476"
] | 11 | [
"1mxq",
"1myu",
"1n6t",
"1p9f",
"2b19",
"2gfr",
"2ks9",
"2ksa",
"2ksb",
"2mce",
"2nor",
"2nou",
"4hom",
"7vdm",
"8jbg",
"8jbh",
"8u26"
] | 17 | [
"PUB00000127",
"PUB00001502",
"PUB00003623"
] | [
"3284438",
"1969374",
"1324401"
] | [
"Tachykinins.",
"Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms.",
"[Tachykinins and conformational aspects of their interactions with receptors]"
] | [
1988,
1990,
1992
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Pyrococcus kukulkanii",
"Viruses",
"bioreactor metagenome"
] | [
125,
2455,
1,
10,
1
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
4,
6,
15
] | 4 | true | Conserved_site | Tachykinin/Neurokinin-like, conserved site | Tachykinin/Neurokinin-like, conserved site | Tachy_Neuro_lke_CS | 7 |
IPR013056 | 13,056 | Bacteriophage lambda, CIII, regulatory protein | Phage_lambda_CIII | Family | 570 | false | false | Bacteriophage lambda regulatory protein CIII is a small protein that plays a role in stabilising the CII transcriptional activator, via a mechanism that is not yet fully understood [ , ]. Stabilised CII activates CI, the gene for the repressor protein that prevents transcription of proteins required for lytic developme... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PROSITE"
] | [
"PF02061",
"PR00936",
"PS00553"
] | [
"Lambda_CIII",
"BPLRPCIII",
"LAMBDA_PHAGE_CIII"
] | [
568,
437,
410
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00004642",
"PUB00004747"
] | [
"2957696",
"1828895"
] | [
"RNase III stimulates the translation of the cIII gene of bacteriophage lambda.",
"The activity of the CIII regulator of lambdoid bacteriophages resides within a 24-amino acid protein domain."
] | [
1987,
1991
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"marine sediment metagenome"
] | [
484,
85,
1
] | 3 | [] | [] | 0 | true | Family | Bacteriophage lambda, CIII, regulatory protein | Bacteriophage lambda, CIII, regulatory protein | Phage_lambda_CIII | 5 |
IPR013061 | 13,061 | Tryptophan/tryrosine permease, conserved site | Trp/try_permease_CS | Conserved_site | 3,632 | false | false | Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [ , , ]. Aromatic amino acids are concentrated in the cytoplasm of Escherichia coli by 4 distinct transport systems: a general aromatic amino a... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00594"
] | [
"AROMATIC_AA_PERMEASE_1"
] | [
3632
] | 1 | [
"PROSITEDOC"
] | [
"PDOC00513"
] | [
"PROSITEDOC:PDOC00513"
] | 1 | [] | 0 | [
"PUB00001779",
"PUB00002131",
"PUB00002141",
"PUB00003402",
"PUB00005006"
] | [
"2687114",
"1987112",
"2022620",
"3146645",
"8382989"
] | [
"Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases.",
"Cloning, nucleotide sequence, and characterization of mtr, the structural gene for a tryptophan-specific permease of Escherichia coli K-12.",
"A new family of integral... | [
1989,
1991,
1991,
1988,
1993
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Protostomia",
"metagenomes"
] | [
3627,
2,
3
] | 3 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Conserved_site | Tryptophan/tryrosine permease, conserved site | Tryptophan/tryrosine permease, conserved site | Trp/try_permease_CS | 4 |
IPR013078 | 13,078 | Histidine phosphatase superfamily, clade-1 | His_Pase_superF_clade-1 | Family | 189,988 | false | false | The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the ... | [] | [] | [] | 0 | [
"PFAM",
"SMART",
"CDD"
] | [
"PF00300",
"SM00855",
"cd07067"
] | [
"His_Phos_1",
"PGAM",
"HP_PGM_like"
] | [
187254,
161202,
170077
] | 3 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"5.4.2",
"5.4.2.11",
"GenProp1248",
"GenProp1306",
"GenProp1349",
"GenProp1366",
"GenProp1378",
"GenProp1407",
"GenProp1454",
"GenProp1599",
"GenProp1612",
"PWY-1622",
"PWY-5484",
"PWY-8004",
"PWY-8404",
"R-BTA-5628897",
"R-BTA-6798695",
"R-BTA-70171",
"R-BTA-70263",
"R-BTA-963... | [
"EC:5.4.2",
"EC:5.4.2.11",
"GP:GenProp1248",
"GP:GenProp1306",
"GP:GenProp1349",
"GP:GenProp1366",
"GP:GenProp1378",
"GP:GenProp1407",
"GP:GenProp1454",
"GP:GenProp1599",
"GP:GenProp1612",
"METACYC:PWY-1622",
"METACYC:PWY-5484",
"METACYC:PWY-8004",
"METACYC:PWY-8404",
"REACTOME:R-BTA-5... | 65 | [
"1bif",
"1bq3",
"1bq4",
"1c7z",
"1c80",
"1c81",
"1e58",
"1e59",
"1ebb",
"1fbt",
"1fzt",
"1h2e",
"1h2f",
"1k6m",
"1qhf",
"1rii",
"1t8p",
"1tip",
"1ujb",
"1ujc",
"1v37",
"1v7q",
"1xq9",
"1yfk",
"1yjx",
"2a6p",
"2a9j",
"2axn",
"2bif",
"2dwo",
"2dwp",
"2ekb"... | 203 | [
"PUB00053493"
] | [
"18092946"
] | [
"The histidine phosphatase superfamily: structure and function."
] | [
2008
] | 1 | [] | [
"IPR003094",
"IPR004449",
"IPR005952",
"IPR011310",
"IPR012398",
"IPR014623",
"IPR014636",
"IPR015845",
"IPR017070",
"IPR017578",
"IPR022492",
"IPR023086"
] | 0 | 12 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
677,
124663,
62249,
76,
2323
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
107,
10,
39,
25,
5,
53,
51,
10,
70,
60,
12,
10,
149
] | 13 | true | Family | Histidine phosphatase superfamily, clade-1 | Histidine phosphatase superfamily, clade-1 | His_Pase_superF_clade-1 | 9 |
IPR013079 | 13,079 | 6-phosphofructo-2-kinase | 6Phosfructo_kin | Domain | 18,880 | false | false | 6-Phosphofructo-2-kinase ( , ) is a bifunctional enzyme that catalyses both the synthesis and the degradation of fructose-2, 6-bisphosphate. The fructose-2,6-bisphosphatase reaction involves a phosphohistidine intermediate. The catalytic pathway is: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate D-fru... | [
"GO:0003873",
"GO:0005524",
"GO:0006000"
] | [
"6-phosphofructo-2-kinase activity",
"ATP binding",
"fructose metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF01591"
] | [
"6PF2K"
] | [
18880
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.105",
"3.1.3.46",
"R-BTA-9634600",
"R-CEL-9634600",
"R-GGA-352875",
"R-GGA-352882",
"R-HSA-163358",
"R-HSA-163767",
"R-HSA-9634600",
"R-MMU-9634600",
"R-RNO-9634600",
"R-SCE-9634600",
"R-SPO-9634600"
] | [
"EC:2.7.1.105",
"EC:3.1.3.46",
"REACTOME:R-BTA-9634600",
"REACTOME:R-CEL-9634600",
"REACTOME:R-GGA-352875",
"REACTOME:R-GGA-352882",
"REACTOME:R-HSA-163358",
"REACTOME:R-HSA-163767",
"REACTOME:R-HSA-9634600",
"REACTOME:R-MMU-9634600",
"REACTOME:R-RNO-9634600",
"REACTOME:R-SCE-9634600",
"REAC... | 13 | [
"1bif",
"1k6m",
"2axn",
"2bif",
"2dwo",
"2dwp",
"2i1v",
"3bif",
"3qpu",
"3qpv",
"3qpw",
"4d4j",
"4d4k",
"4d4l",
"4d4m",
"4ma4",
"5ajv",
"5ajw",
"5ajx",
"5ajy",
"5ajz",
"5ak0",
"5hr5",
"5htk",
"6etj",
"6hvh",
"6hvi",
"6hvj",
"6ibx",
"6iby",
"6ibz",
"6ic0"... | 32 | [
"PUB00000264",
"PUB00001475"
] | [
"9753654",
"9652401"
] | [
"An essential methionine residue involved in substrate binding by phosphofructokinases.",
"Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2)."
] | [
1998,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Bodo saltans virus",
"Eukaryota",
"ecological metagenomes"
] | [
80,
1,
18794,
5
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
3,
27,
5,
29,
31,
4,
11,
40,
4,
4,
18
] | 12 | true | Domain | 6-phosphofructo-2-kinase | 6-phosphofructo-2-kinase | 6Phosfructo_kin | 4 |
IPR013081 | 13,081 | Photosystem II cytochrome b559, N-terminal | PSII_cyt_b559_N | Domain | 28,527 | false | false | Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitti... | [
"GO:0015979"
] | [
"photosynthesis"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF00283"
] | [
"Cytochrom_B559"
] | [
28527
] | 1 | [] | [] | [] | 0 | [
"1izl",
"1s5l",
"1w5c",
"2axt",
"3a0b",
"3a0h",
"3jcu",
"3kzi",
"3wu2",
"4fby",
"4il6",
"4ixq",
"4ixr",
"4pbu",
"4pj0",
"4rvy",
"4tnh",
"4tni",
"4tnj",
"4tnk",
"4ub6",
"4ub8",
"4v62",
"4v82",
"4yuu",
"5b5e",
"5b66",
"5e79",
"5e7c",
"5gth",
"5gti",
"5h2f"... | 168 | [
"PUB00015357",
"PUB00015358",
"PUB00015359",
"PUB00015364",
"PUB00097583",
"PUB00152828"
] | [
"12518057",
"15100025",
"14871485",
"12560096",
"30076221",
"33846594"
] | [
"Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.",
"The evolutionary development of the protein complement of photosystem 2.",
"The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.",
"Mossbauer studies of the non-heme ir... | [
2003,
2004,
2004,
2003,
2018,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
745,
27780,
2
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
10,
4
] | 3 | true | Domain | Photosystem II cytochrome b559, N-terminal | Photosystem II cytochrome b559, N-terminal | PSII_cyt_b559_N | 2 |
IPR013082 | 13,082 | Photosystem II cytochrome b559, alpha subunit, lumenal region | PSII_cytb559_asu_lum | Domain | 14,474 | false | false | Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitti... | [
"GO:0046872",
"GO:0015979",
"GO:0009523",
"GO:0016020"
] | [
"metal ion binding",
"photosynthesis",
"photosystem II",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PFAM"
] | [
"PF00284"
] | [
"Cytochrom_B559a"
] | [
14474
] | 1 | [] | [] | [] | 0 | [
"1izl",
"1s5l",
"1w5c",
"2axt",
"3a0b",
"3a0h",
"3jcu",
"3kzi",
"3wu2",
"4fby",
"4il6",
"4ixq",
"4ixr",
"4pbu",
"4pj0",
"4rvy",
"4tnh",
"4tni",
"4tnj",
"4tnk",
"4ub6",
"4ub8",
"4v62",
"4v82",
"4yuu",
"5b5e",
"5b66",
"5e79",
"5e7c",
"5gth",
"5gti",
"5h2f"... | 168 | [
"PUB00015357",
"PUB00015358",
"PUB00015359",
"PUB00015364",
"PUB00097583",
"PUB00152828"
] | [
"12518057",
"15100025",
"14871485",
"12560096",
"30076221",
"33846594"
] | [
"Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.",
"The evolutionary development of the protein complement of photosystem 2.",
"The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.",
"Mossbauer studies of the non-heme ir... | [
2003,
2004,
2004,
2003,
2018,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
376,
14097,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
4,
2
] | 3 | true | Domain | Photosystem II cytochrome b559, alpha subunit, lumenal region | Photosystem II cytochrome b559, alpha subunit, lumenal region | PSII_cytb559_asu_lum | 9 |
IPR013083 | 13,083 | Zinc finger, RING/FYVE/PHD-type | Znf_RING/FYVE/PHD | Homologous_superfamily | 1,323,224 | false | false | This superfamily represents RING-, PHD-, and FYVE-type zinc finger domains, which share a common dimetal (zinc)-bound α/β structural fold, as well as the non-zinc-containing U-box domain, which is similar to the RING zinc finger only lacking the metal ion-binding residues (U-box associated with multi-ubiquitination). Z... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:3.30.40.10"
] | [
""
] | [
1323224
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-113418",
"R-BTA-1169408",
"R-BTA-1257604",
"R-BTA-141430",
"R-BTA-166058",
"R-BTA-174048",
"R-BTA-174084",
"R-BTA-174154",
"R-BTA-174178",
"R-BTA-174184",
"R-BTA-176407",
"R-BTA-176408",
"R-BTA-176409",
"R-BTA-176412",
"R-BTA-179409",
"R-BTA-182971",
"R-BTA-193692",
"R-BTA-2... | [
"REACTOME:R-BTA-113418",
"REACTOME:R-BTA-1169408",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-141430",
"REACTOME:R-BTA-166058",
"REACTOME:R-BTA-174048",
"REACTOME:R-BTA-174084",
"REACTOME:R-BTA-174154",
"REACTOME:R-BTA-174178",
"REACTOME:R-BTA-174184",
"REACTOME:R-BTA-176407",
"REACTOME:R-BTA-1... | 1,362 | [
"1bor",
"1chc",
"1dvp",
"1e4u",
"1f62",
"1fbv",
"1fp0",
"1g25",
"1hyi",
"1hyj",
"1iym",
"1jm7",
"1joc",
"1k2f",
"1ldj",
"1ldk",
"1mm2",
"1mm3",
"1n87",
"1rmd",
"1t1h",
"1u6g",
"1ur6",
"1v87",
"1vd4",
"1vfy",
"1vyx",
"1we9",
"1wee",
"1wem",
"1wen",
"1weo"... | 1,305 | [
"PUB00014077",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812"
] | [
"12665246",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890"
] | [
"Zinc fingers--folds for many occasions.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc finger proteins: getting a grip on RNA.",
"Zinc finger peptides for the regulation of gene expression.",
"Zinc finger proteins: new ... | [
2002,
2007,
2005,
2005,
1999,
2001
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
172,
6439,
1312030,
2807,
1776
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3435,
329,
2536,
597,
1928,
1278,
105,
2045,
1735,
66,
81,
4443
] | 12 | true | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING/FYVE/PHD-type | Znf_RING/FYVE/PHD | 3 |
IPR013085 | 13,085 | U1-C, C2H2-type zinc finger | U1-CZ_Znf_C2H2 | Domain | 9,776 | false | false | Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b... | [
"GO:0008270"
] | [
"zinc ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF06220"
] | [
"zf-U1"
] | [
9776
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-72163",
"R-BTA-72165",
"R-CFA-72163",
"R-HSA-72163",
"R-HSA-72165",
"R-MMU-72163",
"R-MMU-72165",
"R-RNO-72163"
] | [
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72165",
"REACTOME:R-CFA-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72165",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72165",
"REACTOME:R-RNO-72163"
] | 8 | [
"2vrd",
"3cw1",
"4pjo",
"5o9z",
"5zwn",
"6ahd",
"6g90",
"6n7p",
"6n7r",
"6n7x",
"6qx9",
"7oqc",
"7oqe",
"7vpx",
"8h6k",
"8h6l",
"8q7n",
"8qo9",
"8qpe",
"8qzs",
"8r7n",
"8w2o",
"8y6o",
"9gbw",
"9gc0",
"9gcl"
] | 26 | [
"PUB00012293",
"PUB00014077",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035808",
"PUB00035809",
"PUB00035811",
"PUB00035812",
"PUB00043274"
] | [
"12486009",
"12665246",
"17210253",
"15963892",
"15718139",
"10529348",
"11361095",
"10664601",
"10940247",
"11179890",
"18253864"
] | [
"The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.",
"Zinc fingers--folds for many occasions.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc finger proteins: getting a gri... | [
2002,
2002,
2007,
2005,
2005,
1999,
2001,
2000,
2000,
2001,
2008
] | 11 | [
"IPR000690"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"viral metagenome"
] | [
9775,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
14,
1,
6,
7,
8,
8,
2,
6,
11,
1,
2,
14
] | 12 | true | Domain | U1-C, C2H2-type zinc finger | U1-C, C2H2-type zinc finger | U1-CZ_Znf_C2H2 | 2 |
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