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Drawing room play | A drawing room play is a type of play, developed during the Victorian period in the United Kingdom, in which the actions take place in a drawing room or which is designed to be reenacted in the drawing room of a home. The common practice of entertaining a guest in the home led to the creation of this category of plays and while the drawing room itself has fallen out of favour, the play format has continued to provide a source of entertainment. While there is no date or authority directly ascribed to the term drawing room play, there is evidence that the term was derived from the English habit of putting on these short works for guests while entertaining in the drawing room of the home. In French usage the room and the social gathering it contained are equally the salon. |
Lamination (geology) | In geology, lamination (from Latin lāmina 'thin layer') is a small-scale sequence of fine layers (PL: laminae; SG: lamina) that occurs in sedimentary rocks. Laminae are normally smaller and less pronounced than bedding. Lamination is often regarded as planar structures one centimetre or less in thickness, whereas bedding layers are greater than one centimetre. However, structures from several millimetres to many centimetres have been described as laminae. A single sedimentary rock can have both laminae and beds. |
European College of Veterinary Anaesthesia and Analgesia | The European College of Veterinary Anesthesia and Analgesia (ECVAA) is one of 25 veterinary specialist colleges recognized by the European Board of Veterinary Specialization, comprising more than 35 distinct specialties. |
Chalkstick fracture | Chalkstick fractures are fractures, typically of long bones, in which the fracture is transverse to the long axis of the bone, like a broken stick of chalk. A healthy long bone typically breaks like a hard woody stick as the collagen in the matrix adds remarkable flexibility to the mineral and the energy can run up and down the growth rings of bone. The bones of children will even follow a greenstick fracture pattern. |
Jewellery cleaning | Jewelry cleaning is the practice of removing dirt or tarnish from jewelry to improve its appearance. |
Nucleoside-diphosphatase | In enzymology, a nucleoside-diphosphatase (EC 3.6.1.6) is an enzyme that catalyzes the chemical reaction a nucleoside diphosphate + H2O ⇌ a nucleotide + phosphateThus, the two substrates of this enzyme are nucleoside diphosphate and H2O, whereas its two products are nucleotide and phosphate. |
Panda Cloud Antivirus | Panda Cloud Antivirus is an antivirus software developed by Panda Security, a free and a paid version are available. It is cloud-based in the sense that files are scanned on a remote server without using processing power of the user's machine. The cloud technology is based on Panda's Collective Intelligence. It can run constantly, providing protection against viruses and malicious websites but slowing the system to some extent, or do a system scan. |
Haloperidol decanoate | Haloperidol decanoate, sold under the brand name Haldol Decanoate among others, is a typical antipsychotic which is used in the treatment of schizophrenia. It is administered by injection into muscle at a dose of 100 to 200 mg once every 4 weeks or monthly. The dorsogluteal site is recommended. A 3.75-cm (1.5-inch), 21-gauge needle is generally used, but obese individuals may require a 6.5-cm (2.5-inch) needle to ensure that the drug is indeed injected intramuscularly and not subcutaneously. Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. Its elimination half-life after multiple doses is 21 days. The medication is marketed in many countries throughout the world. |
Coloplast | Coloplast A/S is a Danish multinational company that develops, manufactures and markets medical devices and services related to ostomy, urology, continence, and wound care. |
Gold heptafluoride | Gold heptafluoride is a gold(V) compound with the empirical formula AuF7. The synthesis of this compound was first reported in 1986. However, current calculations suggest that the structure of the synthesized molecule was actually a difluorine ligand on a gold pentafluoride core, AuF5·F2. That would make it the first difluorine complex and the first compound containing a fluorine atom with an oxidation state of zero. The gold(V)–difluorine complex is calculated to be 205 kJ/mol more stable than gold(VII) fluoride. The vibrational frequency at 734 cm−1 is the hallmark of the end-on coordinated difluorine molecule. |
Associative browsing | Associative browsing is the professional name for several methods of browsing the web. These methods are usually assisted by some sort of a discovery tool and are considered to be more intuitive.
The tools that serve the associative browsing are similarity/relevancy tools. They use different algorithms to analyze the content and the user in order to offer him or direct him to the next link in what is considered his associative chain.
One of the more familiar sites to use the associative browsing method was Pandora.com, the site used a relevancy engine to bring users music they would like according to the music they are listening right now. The site's algorithm tried to forecast the next link (in this case a song) in the user's associative chain. |
Orthonormality | In linear algebra, two vectors in an inner product space are orthonormal if they are orthogonal (or perpendicular along a line) unit vectors. A set of vectors form an orthonormal set if all vectors in the set are mutually orthogonal and all of unit length. An orthonormal set which forms a basis is called an orthonormal basis. |
Ankyrin repeat domain 11 | Ankyrin repeat domain 11 is a protein that in humans is encoded by the ANKRD11 gene. |
4-Oxo-2-nonenal | 4-Oxo-2-nonenal is a lipid peroxidation product that can structurally alter proteins and induce α-synuclein oligomers. |
Freight terminal | A freight terminal is a processing node for freight. They may include airports, seaports, container ports, goods stations, railroad terminals and trucking terminals. As most freight terminals are located at ports, many cargo containers can be seen around the area. |
Vancomycin-resistant Staphylococcus aureus | Vancomycin-resistant Staphylococcus aureus (VRSA) are strains of Staphylococcus aureus that have acquired resistance to the glycopeptide antibiotic vancomycin. Resistance in VRSA is conferred by the plasmid mediated vanA gene and operon. Although VRSA infections are limited, VRSA is still a potential threat to public health because treatment options are limited since the bacteria is resistant to many of the standard drugs used to treat S. aureus infections. Furthermore, resistance can be transferred from one bacteria to another. |
Paste up | Paste up is a method of creating or laying out publication pages that predates the use of the now-standard computerized page design desktop publishing programs. Completed, or camera-ready, pages are known as mechanicals or mechanical art. In the offset lithography process, the mechanicals would be photographed with a stat camera to create a same-size film negative for each printing plate required. |
Distorted thread locknut | A distorted thread locknut, is a type of locknut that uses a deformed section of thread to keep the nut from loosening from vibrations or rotation of the clamped item. They are broken down into four types: elliptical offset nuts, centerlock nuts, toplock nuts and partially depitched (Philidas) nuts. |
Quantum cognition | Quantum cognition is an emerging field which applies the mathematical formalism of quantum theory to model cognitive phenomena such as information processing by the human brain, language, decision making, human memory, concepts and conceptual reasoning, human judgment, and perception. The field clearly distinguishes itself from the quantum mind as it is not reliant on the hypothesis that there is something micro-physical quantum-mechanical about the brain. Quantum cognition is based on the quantum-like paradigm or generalized quantum paradigm or quantum structure paradigm that information processing by complex systems such as the brain, taking into account contextual dependence of information and probabilistic reasoning, can be mathematically described in the framework of quantum information and quantum probability theory. |
Quillen–Lichtenbaum conjecture | In mathematics, the Quillen–Lichtenbaum conjecture is a conjecture relating étale cohomology to algebraic K-theory introduced by Quillen (1975, p. 175), who was inspired by earlier conjectures of Lichtenbaum (1973). Kahn (1997) and Rognes & Weibel (2000) proved the Quillen–Lichtenbaum conjecture at the prime 2 for some number fields. Voevodsky, using some important results of Markus Rost, has proved the Bloch–Kato conjecture, which implies the Quillen–Lichtenbaum conjecture for all primes. |
1,3-beta-D-glucan phosphorylase | In enzymology, a 1,3-beta-D-glucan phosphorylase (EC 2.4.1.97) is an enzyme that catalyzes the chemical reaction (1,3-beta-D-glucosyl)n + phosphate ⇌ (1,3-beta-D-glucosyl)n-1 + alpha-D-glucose 1-phosphateThus, the two substrates of this enzyme are (1,3-beta-D-glucosyl)n and phosphate, whereas its two products are (1,3-beta-D-glucosyl)n-1 and alpha-D-glucose 1-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is 1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase. Other names in common use include laminarin phosphoryltransferase, 1,3-beta-D-glucan:orthophosphate glucosyltransferase, and laminarin phosphoryltransferase. |
Circuit breaker analyzer | A circuit breaker analyzer is an instrument that measures the parameters of a circuit breaker.In 1984, Megger patented a digital circuit breaker analyzer, controlled by a microprocessor. in 2020 few companies develop software to control circuit breaker analyzers from different devices such as computers, tablet computer, smartphones and others.The following tests can be carried out on the circuit breaker: mechanical, thermal, dielectric, short-circuit. |
Estradiol (medication) | Estradiol (E2) is a medication and naturally occurring steroid hormone. It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women. It is also used in hormonal birth control for women, in hormone therapy for transgender women, and in the treatment of hormone-sensitive cancers like prostate cancer in men and breast cancer in women, among other uses. Estradiol can be taken by mouth, held and dissolved under the tongue, as a gel or patch that is applied to the skin, in through the vagina, by injection into muscle or fat, or through the use of an implant that is placed into fat, among other routes.Side effects of estradiol in women include breast tenderness, breast enlargement, headache, fluid retention, and nausea among others. Men and children who are exposed to estradiol may develop symptoms of feminization, such as breast development and a feminine pattern of fat distribution, and men may also experience low testosterone levels and infertility. Estradiol may increase the risk of endometrial hyperplasia and endometrial cancer in women with intact uteruses if it is not taken together with a progestogen such as progesterone. The combination of estradiol with a progestin, though not with oral progesterone, may increase the risk of breast cancer. Estradiol should not be used in women who are pregnant or breastfeeding or who have breast cancer, among other contraindications.Estradiol is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like endogenous estradiol. Due to its estrogenic activity, estradiol has antigonadotropic effects and can inhibit fertility and suppress sex hormone production in both women and men. Estradiol differs from non-bioidentical estrogens like conjugated estrogens and ethinylestradiol in various ways, with implications for tolerability and safety.Estradiol was discovered in 1933. It became available as a medication that same year, in an injectable form known as estradiol benzoate. Forms that were more useful by mouth, estradiol valerate and micronized estradiol, were introduced in the 1960s and 1970s and increased its popularity by this route. Estradiol is also used as other prodrugs, like estradiol cypionate. Related estrogens such as ethinylestradiol, which is the most common estrogen in birth control pills, and conjugated estrogens (brand name Premarin), which is used in menopausal hormone therapy, are used as medications as well. In 2020, it was the 59th most commonly prescribed medication in the United States, with more than 11 million prescriptions. It is available as a generic medication. |
SKIM | Sea surface kinematics multiscale monitoring (SKIM) was one of the two candidate missions for the 9th Earth Explorer mission of in the Living Planet Programme of the European Space Agency (ESA). SKIM and the other candidate (FORUM) were pre-selected for a detailed study in November 2017. Only one of the two candidates was to be selected in 2019 for immediate implementation and a possible launch by the year 2025, and FORUM was chosen. |
Rydberg matter | Rydberg matter is an exotic phase of matter formed by Rydberg atoms; it was predicted around 1980 by É. A. Manykin, M. I. Ozhovan and P. P. Poluéktov. It has been formed from various elements like caesium, potassium, hydrogen and nitrogen; studies have been conducted on theoretical possibilities like sodium, beryllium, magnesium and calcium. It has been suggested to be a material that diffuse interstellar bands may arise from. Circular Rydberg states, where the outermost electron is found in a planar circular orbit, are the most long-lived, with lifetimes of up to several hours, and are the most common. |
Isotropic quadratic form | In mathematics, a quadratic form over a field F is said to be isotropic if there is a non-zero vector on which the form evaluates to zero. Otherwise the quadratic form is anisotropic. More explicitly, if q is a quadratic form on a vector space V over F, then a non-zero vector v in V is said to be isotropic if q(v) = 0. A quadratic form is isotropic if and only if there exists a non-zero isotropic vector (or null vector) for that quadratic form. Suppose that (V, q) is quadratic space and W is a subspace of V. Then W is called an isotropic subspace of V if some vector in it is isotropic, a totally isotropic subspace if all vectors in it are isotropic, and an anisotropic subspace if it does not contain any (non-zero) isotropic vectors. The isotropy index of a quadratic space is the maximum of the dimensions of the totally isotropic subspaces.A quadratic form q on a finite-dimensional real vector space V is anisotropic if and only if q is a definite form: either q is positive definite, i.e. q(v) > 0 for all non-zero v in V ; or q is negative definite, i.e. q(v) < 0 for all non-zero v in V.More generally, if the quadratic form is non-degenerate and has the signature (a, b), then its isotropy index is the minimum of a and b. An important example of an isotropic form over the reals occurs in pseudo-Euclidean space. |
Integrated Encryption Scheme | Integrated Encryption Scheme (IES) is a hybrid encryption scheme which provides semantic security against an adversary who is able to use chosen-plaintext or chosen-ciphertext attacks. The security of the scheme is based on the computational Diffie–Hellman problem.
Two variants of IES are specified: Discrete Logarithm Integrated Encryption Scheme (DLIES) and Elliptic Curve Integrated Encryption Scheme (ECIES), which is also known as the Elliptic Curve Augmented Encryption Scheme or simply the Elliptic Curve Encryption Scheme. These two variants are identical up to the change of an underlying group. |
Internal combustion engine cooling | Internal combustion engine cooling uses either air or liquid to remove the waste heat from an internal combustion engine. For small or special purpose engines, cooling using air from the atmosphere makes for a lightweight and relatively simple system. Watercraft can use water directly from the surrounding environment to cool their engines. For water-cooled engines on aircraft and surface vehicles, waste heat is transferred from a closed loop of water pumped through the engine to the surrounding atmosphere by a radiator. |
Molecular Materials Research Group | The Molecular Materials Research Group (MMRG) is a multidisciplinary research group composed of several Ph.D. members as well as the expertise of other researchers in the field of Computational, Organic and Analytical Chemistry.Located at Madeira University in Madeira, its main scientific activity is devoted to the preparation and characterization of potentially useful molecular materials with enhanced electronic and biomedical properties. The development of new materials based in dendrimers for gene delivery and for non-linear optical applications is one of their primary goals. |
Hypoestrogenism | Hypoestrogenism, or estrogen deficiency, refers to a lower than normal level of estrogen. It is an umbrella term used to describe estrogen deficiency in various conditions. Estrogen deficiency is also associated with an increased risk of cardiovascular disease, and has been linked to diseases like urinary tract infections and osteoporosis. |
Environment of Russia | The climate of Russia is formed under the European peninsula. The enormous size of the country and the remoteness of many areas from the sea result in the dominance of the continental climate, which is prevalent in European and Asian Russia except for the tundra and the best extreme southeast. Mountains in the south obstructing the flow of cold air masses from the Arctic Ocean and the plain of the south and north makes the country open to Pacific and Atlantic influences. |
Helpmate | A helpmate is a type of chess problem in which both sides cooperate in order to achieve the goal of checkmating Black. In a helpmate in n moves, Black moves first, then White, each side moving n times, to culminate in White's nth move checkmating Black. (In a helpmate in 2 for example, sometimes abbreviated h#2, the solution consists of a Black move, a White move, a second Black move, then a second White move, giving checkmate.) Although the two sides cooperate, all moves must be legal according to the rules of chess. |
Convex Polyhedra (book) | Convex Polyhedra is a book on the mathematics of convex polyhedra, written by Soviet mathematician Aleksandr Danilovich Aleksandrov, and originally published in Russian in 1950, under the title Выпуклые многогранники. It was translated into German by Wilhelm Süss as Konvexe Polyeder in 1958. An updated edition, translated into English by Nurlan S. Dairbekov, Semën Samsonovich Kutateladze and Alexei B. Sossinsky, with added material by Victor Zalgaller, L. A. Shor, and Yu. A. Volkov, was published as Convex Polyhedra by Springer-Verlag in 2005. |
Planetary phase | A planetary phase is a certain portion of a planet's area that [[diffuse reflecti ntage point, as well as the period of time during which it occurs. |
Method of support | In statistics, the method of support is a technique that is used to make inferences from datasets. |
Staggered tuning | Staggered tuning is a technique used in the design of multi-stage tuned amplifiers whereby each stage is tuned to a slightly different frequency. In comparison to synchronous tuning (where each stage is tuned identically) it produces a wider bandwidth at the expense of reduced gain. It also produces a sharper transition from the passband to the stopband. Both staggered tuning and synchronous tuning circuits are easier to tune and manufacture than many other filter types. |
The Appropriate Technology Library | The Appropriate Technology Library consists of 1050 books on 29 subject areas of small scale, do-it-yourself technology. Originally developed by Volunteers in Asia (VIA) it was transferred to Village Earth: The Consortium for Sustainable Village-Based Development in 1993.
The Library was developed to be a low-cost and portable source of appropriate technology information for aid and relief workers around the world. Since its inception, it has been used in dozens of countries around the world. |
Shot noise | Shot noise or Poisson noise is a type of noise which can be modeled by a Poisson process. In electronics shot noise originates from the discrete nature of electric charge. Shot noise also occurs in photon counting in optical devices, where shot noise is associated with the particle nature of light. |
Piece goods | Piece goods were the textile materials sold in cut pieces as per the buyer's specification. The piece goods were either cut from a fabric roll or produced with a certain length, also called yard goods. Various textiles such as cotton, wool, silk, etc., were traded in terms of piece goods. The prices were determined as per the fabric quality.John Forbes Watson classified Indian textiles into two types: piece goods and loom goods. Piece goods are materials that must be cut and sewn before they can be used, whereas loom goods, such as scarves and Saris, are ready to use after leaving the loom. |
Steinmetz solid | In geometry, a Steinmetz solid is the solid body obtained as the intersection of two or three cylinders of equal radius at right angles. Each of the curves of the intersection of two cylinders is an ellipse.
The intersection of two cylinders is called a bicylinder. Topologically, it is equivalent to a square hosohedron. The intersection of three cylinders is called a tricylinder. A bisected bicylinder is called a vault, and a cloister vault in architecture has this shape.
Steinmetz solids are named after mathematician Charles Proteus Steinmetz, who solved the problem of determining the volume of the intersection. However, the same problem had been solved earlier, by Archimedes in the ancient Greek world, Zu Chongzhi in ancient China, and Piero della Francesca in the early Italian Renaissance. |
Drug of last resort | A drug of last resort (DoLR), also known as a heroic dose, is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient. Drug resistance, such as antimicrobial resistance or antineoplastic resistance, may make the first-line drug ineffective, especially in case of multidrug-resistant pathogens and tumors. Such an alternative may be outside of extant regulatory requirements or medical best practices, in which case it may be viewed as salvage therapy. |
Agda (programming language) | Agda is a dependently typed functional programming language originally developed by Ulf Norell at Chalmers University of Technology with implementation described in his PhD thesis. The original Agda system was developed at Chalmers by Catarina Coquand in 1999. The current version, originally known as Agda 2, is a full rewrite, which should be considered a new language that shares a name and tradition. |
Thermization | Thermization, also spelled thermisation, is a method of sanitizing raw milk with low heat. "Thermization is a generic description of a range of subpasteurization heat treatments (57 to 68°C × 10 to 20 s) that markedly reduce the number of spoilage bacteria in milk with minimal heat damage." The process is not used on other food products, and is similar to pasteurization but uses lower temperatures, allowing the milk product to retain more of its original taste. In Europe, there is a distinction between cheeses made of thermized milk and raw-milk cheeses. However, the United States' Food and Drug Administration (FDA) places the same regulations on all unpasteurized cheeses. As a result, cheeses from thermized milk must be aged for 60 days or more before being sold in the United States, the same restriction placed on raw-milk cheeses by the FDA.Thermization involves heating milk at temperatures of around 145–149 °F (63–65 °C) for 15 seconds, while pasteurization involves heating milk at 160 °F (71 °C) for 15 seconds or at 145 °F (63 °C) for 30 minutes. Thermization is used to extend the keeping quality of raw milk (the length of time that milk is suitable for consumption) when it cannot be immediately used in other products, such as cheese. Thermization can also be used to extend the storage life of fermented milk products by inactivating microorganisms in the product.Thermization inactivates psychrotrophic bacteria in milk and allows the milk to be stored below 8 °C (46 °F) for three days, or stored at 0–1 °C (32–34 °F) for seven days. Later, the milk may be given stronger heat treatment to be preserved longer. Cooling thermized milk before reheating is necessary to delay/prevent the outgrowth of bacterial spores. When the milk is first heated, spores can begin to germinate, but their growth can be halted or delayed when the milk is refrigerated, depending on the microorganisms' growth requirements. Germinated spores are sensitive to subsequent heating, however since germination is not a homogeneous process, not all spores will germinate or be inactivated by subsequent heating. |
Sony FE 16-35mm F2.8 GM | The Sony FE 16-35mm F2.8 GM is a premium constant maximum aperture wide-angle full-frame (FE) zoom lens for the Sony E-mount, announced by Sony on May 17, 2017. The lens is scheduled for release on August 31, 2017.This lens is part of Sony's professional GM zoom lens of the FE 12-24mm F2.8, FE 16-35mm F2.8, FE 24-70mm F2.8, and FE 70-200mm F2.8. Though designed for Sony's full frame E-mount cameras, the lens can be used on Sony's APS-C E-mount camera bodies, with an equivalent full-frame field-of-view of 24–52.5mm. |
Supplementary weaving | Supplementary weaving is a decorative technique in which additional threads are woven into a textile to create an ornamental pattern in addition to the ground pattern. The supplementary weave can be of the warp or of the weft. Supplementary weave is commonly used in many of thetextiles of Southeast Asia such as in Balinese textiles, the textiles of Sumba and the songket of Sumatra, Malaysia and Brunei. |
Ancestry-informative marker | In population genetics, an ancestry-informative marker (AIM) is a single-nucleotide polymorphism that exhibits substantially different frequencies between different populations. A set of many AIMs can be used to estimate the proportion of ancestry of an individual derived from each population. |
Meteorological instrumentation | Meteorological instruments (or weather instruments), including meteorological sensors (weather sensors), are the equipment used to find the state of the atmosphere at a given time. Each science has its own unique sets of laboratory equipment. Meteorology, however, is a science which does not use much laboratory equipment but relies more on on-site observation and remote sensing equipment. In science, an observation, or observable, is an abstract idea that can be measured and for which data can be taken. Rain was one of the first quantities to be measured historically. Two other accurately measured weather-related variables are wind and humidity. Many attempts had been made prior to the 15th century to construct adequate equipment to measure atmospheric variables. |
Bhimpalasi | Bhimpalasi or Bheempalasi (also known as Bhimpalas or Bheempalas) is a joint raga or “jor raga” it's a mixture of raga "bhim(Bheem) also known as raga gavti" and raga "palasi or palas" , where raga bhim is a creation of babaAllauddin Khan (founder of rampur maihar seniya gharana) and raga palasi is a traditional raga Raga Bhimpalasi belongs to the Kafi Thaat. |
Iff card | Iff card is a contactless smart card introduced in Cardiff in 2010. It allows customers to travel on Cardiff Bus services after having pre-paid.The name "Iff card" is a play on the word "Cardiff". |
Paul Babitzke | Paul Babitzke is a professor of biochemistry and molecular biology and director of the Center for RNA Molecular Biology at Pennsylvania State University. |
Beckmann thermometer | A Beckmann thermometer is a device used to measure small differences of temperature, but not absolute temperature values. It was invented by Ernst Otto Beckmann (1853 – 1923), a German chemist, for his measurements of colligative properties in 1905. Today its use has largely been superseded by platinum PT100 resistance thermometers and thermocouples. |
Dog Barbos and Unusual Cross | Dog Barbos and Unusual Cross or (Russian: Пёс Барбос и необычный кросс, romanized: Pyos Barbos i neobychnij kross) is a 1961 Soviet short comedy film directed by Leonid Gaidai. |
Autosomal dominant hypophosphatemic rickets | Autosomal dominant hypophosphatemic rickets (ADHR) is a rare hereditary disease in which excessive loss of phosphate in the urine leads to poorly formed bones (rickets), bone pain, and tooth abscesses. ADHR is caused by a mutation in the fibroblast growth factor 23 (FGF23). ADHR affects men and women equally; symptoms may become apparent at any point from childhood through early adulthood. Blood tests reveal low levels of phosphate (hypophosphatemia) and inappropriately normal levels of vitamin D. Occasionally, hypophosphatemia may improve over time as urine losses of phosphate partially correct.ADHR may be lumped in with X-linked hypophosphatemia under general terms such as hypophosphatemic rickets. Hypophosphatemic rickets are associated with at least nine other genetic mutations. Clinical management of hypophosphatemic rickets may differ depending on the specific mutations associated with an individual case, but treatments are aimed at raising phosphate levels to promote normal bone formation. In a 2019 randomised, clinical trial the rickets in children with X-linked hypophosphataemia treated with a human monoclonal antibody against FGF23 called burosumab improved significantly compared to conventional therapy. |
Shadow marks | Shadow marks (shadow relief) are a form of archaeological feature visible from the air. Unlike cropmarks, frost marks and soil marks they require upstanding features to work and are therefore more commonly seen in the context of extant sites rather than previously undiscovered buried ones. |
Potential flow around a circular cylinder | In mathematics, potential flow around a circular cylinder is a classical solution for the flow of an inviscid, incompressible fluid around a cylinder that is transverse to the flow. Far from the cylinder, the flow is unidirectional and uniform. The flow has no vorticity and thus the velocity field is irrotational and can be modeled as a potential flow. Unlike a real fluid, this solution indicates a net zero drag on the body, a result known as d'Alembert's paradox. |
EOTD | eOTD is the acronym for the ECCMA Open Technical Dictionary. The dictionary is a language-independent database of concepts with associated terms, definitions and images used to unambiguously describe individuals, organizations, locations, goods, services, processes, rules, and regulations. The eOTD is maintained by the Electronic Commerce Code Management Association (ECCMA). |
Smoke point | The smoke point, also referred to as the burning point, is the temperature at which an oil or fat begins to produce a continuous bluish smoke that becomes clearly visible, dependent upon specific and defined conditions. Smoke point values can vary greatly, depending on factors such as the volume of oil utilized, the size of the container, the presence of air currents, the type and source of light as well as the quality of the oil and its acidity content, otherwise known as free fatty acid (FFA) content. The more FFA an oil contains, the quicker it will break down and start smoking. The lower the value of FFA, the higher the smoke point. However, the FFA content typically represents less than 1% of the total oil and consequently renders smoke point a poor indicator of the capacity of a fat or oil to withstand heat. |
Articular cartilage repair | Articular cartilage repair treatment involves the repair of the surface of an articular joint's hyaline cartilage. Over the last few decades, surgeons and researchers have made progress in elaborating surgical cartilage repair interventions. Though these solutions do not perfectly restore the articular cartilage, some of the latest technologies have started to bring very promising results in repairing cartilages from traumatic injuries or chondropathies. These treatments have been shown to be especially beneficial for patients who have articular cartilage damage. They can provide some measure of pain relief, while at the same time slowing down the accumulation of damage, or considerably delaying the need for joint replacement (knee replacement) surgery. |
Cholesterol oxidase | In enzymology, a cholesterol oxidase (EC 1.1.3.6) is an enzyme that catalyzes the chemical reaction cholesterol + O2 ⇌ cholest-4-en-3-one + H2O2Thus, the two substrates of this enzyme are cholesterol and O2, whereas its two products are cholest-4-en-3-one and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is cholesterol:oxygen oxidoreductase. Other names in common use include cholesterol- O2 oxidoreductase, 3beta-hydroxy steroid oxidoreductase, and 3beta-hydroxysteroid:oxygen oxidoreductase. This enzyme participates in bile acid biosynthesis.
The substrate-binding domain found in some bacterial cholesterol oxidases is composed of an eight-stranded mixed beta-pleated sheet and six alpha-helices. This domain is positioned over the isoalloxazine ring system of the FAD cofactor bound by the FAD-binding domain and forms the roof of the active site cavity, allowing for catalysis of oxidation and isomerisation of cholesterol to cholest-4-en-3-one. |
Visual snow syndrome | Visual snow syndrome (VSS) is an uncommon neurological condition in which the primary symptom is that affected individuals see persistent flickering white, black, transparent, or coloured dots across the whole visual field. Other common symptoms are palinopsia, enhanced entoptic phenomena, photophobia, and tension headaches. The condition is typically always present and has no known cure, as viable treatments are still under research. Astigmatism, although not presumed connected to these visual disturbances, is a common comorbidity. As well, migraine and tinnitus are common comorbidities which are both associated with a more severe presentation of the syndrome. TMJ may also be a common comorbidity.The cause of the syndrome is unclear. The underlying mechanism is believed to involve excessive excitability of neurons in the right lingual gyrus and left anterior lobe of cerebellum. Another hypothesis proposes that visual snow syndrome could be a type of thalamocortical dysrhythmia and may involve the thalamic reticular nucleus (TRN). A failure of inhibitory action from the TRN to the thalamus may be the underlying cause for inability to suppress excitatory sensory information. Research has been limited due to issues of case identification and diagnosis, the latter now largely addressed, and the limited size of any studied cohort. Initial functional brain imaging research suggests visual snow is a brain disorder. |
Cyclohexene oxide | Cyclohexene oxide is a cycloaliphatic epoxide. It can react in cationic polymerization to poly(cyclohexene oxide). As cyclohexene is monovalent, poly(cyclohexene oxide) is a thermoplastic. |
Ferrocerium | Ferrocerium (also known in Europe as Auermetall) is a synthetic pyrophoric alloy of mischmetal (cerium, lanthanum, neodymium, other trace lanthanides and some iron – about 95% lanthanides and 5% iron) hardened by blending in oxides of iron and/or magnesium. When struck with a harder material, the mixture produces hot sparks that can reach temperatures of 3,315 °C (6,000 °F) when rapidly oxidized by the process of striking the rod. Striking both scrapes fragments off, exposing them to the oxygen in the air, and easily ignites them by friction heat due to cerium's remarkably low ignition temperature of between 150–180 °C (302–356 °F). |
Cinder track | A cinder track is a type of race track, generally purposed for track and field or horse racing, whose surface is composed of cinders. For running tracks, many cinder surfaces have been replaced by all-weather synthetic surfaces, which provide greater durability and more consistent results, and are less stressful on runners. The impact on performance as a result of differing track surfaces is a topic often raised when comparing athletes from different eras.Synthetic tracks emerged in the late 1960s; the 1964 Olympics were the last to use a cinder track.The Little 500 bicycle race at Indiana University is still run annually on a cinder track. |
P-Dioxanone | p-Dioxanone (1,4-dioxan-2-one) is the lactone of 2-(2-hydroxyethoxy)acetic acid. It is a monomer that can undergo ring-opening polymerization to give polydioxanone, a biodegradable implant material. It is isomeric to trimethylene carbonate (1,3-dioxan-2-one). |
Mexrenoic acid | Mexrenoic acid, or mexrenoate, is a synthetic steroidal antimineralocorticoid which was never marketed. |
Sulfur water | Sulfur water (or sulphur water) is a condition where water is exposed to hydrogen sulfide gas, giving a distinct "rotten egg" smell. This condition has different purposes in culture varying to health and implications to plumbing. |
NPR1 | Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene. |
Hashtag | A hashtag is a metadata tag that is prefaced by the hash symbol, #. On social media, hashtags are used on microblogging and photo-sharing services such as Twitter or Tumblr as a form of user-generated tagging that enables cross-referencing of content by topic or theme. For example, a search within Instagram for the hashtag #bluesky returns all posts that have been tagged with that term. After the initial hash symbol, a hashtag may include letters, numerals, or underscores.The use of hashtags was first proposed by American blogger and product consultant Chris Messina in a 2007 tweet. Messina made no attempt to patent the use because he felt that "they were born of the internet, and owned by no one". Hashtags became entrenched in the culture of Twitter and soon emerged across Instagram, Facebook, and YouTube. In June 2014, hashtag was added to the Oxford English Dictionary as "a word or phrase with the symbol # in front of it, used on social media websites and apps so that you can search for all messages with the same subject". |
Duhem–Margules equation | The Duhem–Margules equation, named for Pierre Duhem and Max Margules, is a thermodynamic statement of the relationship between the two components of a single liquid where the vapour mixture is regarded as an ideal gas: ln ln ln ln xB)T,P where PA and PB are the partial vapour pressures of the two constituents and xA and xB are the mole fractions of the liquid. The equation gives the relation between changes in mole fraction and partial pressure of the components. |
Curium | Curium is a transuranic, radioactive chemical element with the symbol Cm and atomic number 96. This actinide element was named after eminent scientists Marie and Pierre Curie, both known for their research on radioactivity. Curium was first intentionally made by the team of Glenn T. Seaborg, Ralph A. James, and Albert Ghiorso in 1944, using the cyclotron at Berkeley. They bombarded the newly discovered element plutonium (the isotope 239Pu) with alpha particles. This was then sent to the Metallurgical Laboratory at University of Chicago where a tiny sample of curium was eventually separated and identified. The discovery was kept secret until after the end of World War II. The news was released to the public in November 1947. Most curium is produced by bombarding uranium or plutonium with neutrons in nuclear reactors – one tonne of spent nuclear fuel contains ~20 grams of curium. |
Primordial cyst | A primordial cyst is a developmental odontogenic cyst. It is found in an area where a tooth should have formed but is missing. Primordial cysts most commonly arise in the area of mandibular third molars. Under microscopes, the cyst looks like an odontogenic keratocyst (also called a Keratocyst odontogenic tumor) whereby the lesions displays a parakeratinized epithelium with palisading basal epithelial cells. |
Cornhole | Bags (also known regionally as sack toss, or Cornhole) is a lawn game popular in North America in which players or teams take turns throwing fabric bean bags at a raised, angled board with a hole in its far end. The goal of the game is to score points by either landing a bag on the board (one point) or putting a bag through the hole (three points). |
Capacity factor | The net capacity factor is the unitless ratio of actual electrical energy output over a given period of time to the theoretical maximum electrical energy output over that period. The theoretical maximum energy output of a given installation is defined as that due to its continuous operation at full nameplate capacity over the relevant period. The capacity factor can be calculated for any electricity producing installation, such as a fuel consuming power plant or one using renewable energy, such as wind or the sun. The average capacity factor can also be defined for any class of such installations, and can be used to compare different types of electricity production. |
Acoustic theory | Acoustic theory is a scientific field that relates to the description of sound waves. It derives from fluid dynamics. See acoustics for the engineering approach. |
Folch solution | A Folch solution is a solution containing chloroform and methanol, usually in a 2:1 (vol/vol) ratio. One of its uses is in separating polar from nonpolar compounds, for example separating nonpolar lipids from polar proteins and carbohydrates in blood serum. |
Fire adaptations | Fire adaptations are traits of plants and animals that help them survive wildfire or to use resources created by wildfire. These traits can help plants and animals increase their survival rates during a fire and/or reproduce offspring after a fire. Both plants and animals have multiple strategies for surviving and reproducing after fire. Plants in wildfire-prone ecosystems often survive through adaptations to their local fire regime. Such adaptations include physical protection against heat, increased growth after a fire event, and flammable materials that encourage fire and may eliminate competition. |
Merochlorophaeic acid | Merochlorophaeic acid is a depside with the molecular formula C24H30O8 which has been isolated from the lichen Cladonia merochlorophaea. |
Drum stick | A drum stick (or drumstick) is a type of percussion mallet used particularly for playing snare drum, drum kit, and some other percussion instruments, and particularly for playing unpitched percussion.
Specialized beaters used on some other percussion instruments, such as the metal beater used with a triangle or the mallets used with tuned percussion (such as xylophone and timpani), are not normally referred to as drumsticks. Drumsticks generally have all of the following characteristics: They are normally supplied and used in pairs.
They may be used to play at least some sort of drum (as well as other instruments).
They are normally used only for unpitched percussion. |
Inclusive Skating | Inclusive Skating is a charity that provides opportunities for skaters with additional needs. They cater to skaters of all levels, ranging from first-timers to recreational skaters, to elite competitive level athletes and hold events on a global scale which utilise their own judging framework developed for judging skaters who have additional challenges. |
ISO 9 | ISO 9 is an international standard establishing a system for the transliteration into Latin characters of Cyrillic characters constituting the alphabets of many Slavic and non-Slavic languages.Published on February 23, 1995 by the International Organization for Standardization, the major advantage ISO 9 has over other competing systems is its univocal system of one character for one character equivalents (by the use of diacritics), which faithfully represents the original spelling and allows for reverse transliteration, even if the language is unknown. |
Schur product theorem | In mathematics, particularly in linear algebra, the Schur product theorem states that the Hadamard product of two positive definite matrices is also a positive definite matrix. |
Polymer engineering | Polymer engineering is generally an engineering field that designs, analyses, and modifies polymer materials. Polymer engineering covers aspects of the petrochemical industry, polymerization, structure and characterization of polymers, properties of polymers, compounding and processing of polymers and description of major polymers, structure property relations and applications. |
Natural Language and Linguistic Theory | Natural Language & Linguistic Theory is a quarterly peer-reviewed academic journal covering theoretical and generative linguistics. It was established in 1983 and originally published by Kluwer Academic Publishers. Since 2004 the journal is published by Springer Science+Business Media. The editor-in-chief is Julie Anne Legate (University of Pennsylvania).
The journal carries a "Topic-Comment" column (initiated by Geoffrey K. Pullum), in which a contributor presents a personal, sometimes controversial, opinion on some aspect of the field. |
Stook | A stook /stʊk/, also referred to as a shock or stack, is an arrangement of sheaves of cut grain-stalks placed so as to keep the grain-heads off the ground while still in the field and before collection for threshing. Stooked grain sheaves are typically wheat, barley and oats. In the era before combine harvesters and powered grain driers, stooking was necessary to dry the grain for a period of days to weeks before threshing, to achieve a moisture level low enough for storage. In the 21st century, most grain is produced with the mechanized and powered methods, and is therefore not stooked at all. However, stooking remains useful to smallholders who grow their own grain, or at least some of it, as opposed to buying it. |
Maxwell Montes | Maxwell Montes is a mountain massif on the planet Venus, of which Skadi Mons is the highest point on the planet's surface. |
Fexaramine | Fexaramine is an investigational compound which acts as an agonist of the farnesoid X receptor (FXR), which is a bile acid-activated nuclear receptor that controls bile-acid synthesis, conjugation and transport, as well as lipid metabolism through actions in the liver and intestine.The first publication about fexaramine in 2003 showed it has 100-fold greater affinity for FXR than natural compounds and described the genomic targets and binding site on FXR.When administered orally to mice, fexaramine produced selective actions through FXR receptors in the intestines. Consistent with the effects of other FXR agonist drugs, in a study in mice, oral fexaramine stimulated intestinal fibroblast growth factor 15 (FGF15) production and resulted in metabolic improvements. Intestinal tissue-specific actions of fexaramine were suggested to be a possible new approach for the treatment of obesity and metabolic syndrome. However it cannot be determined from these preliminary results in mice whether FXR agonism with fexaramine will produce weight loss in humans. There are no clinical trials of fexaramine planned in humans and therapy with such FXR agonists for obesity is only a theoretical approach. |
Medical classification | A medical classification is used to transform descriptions of medical diagnoses or procedures into standardized statistical code in a process known as clinical coding. Diagnosis classifications list diagnosis codes, which are used to track diseases and other health conditions, inclusive of chronic diseases such as diabetes mellitus and heart disease, and infectious diseases such as norovirus, the flu, and athlete's foot. Procedure classifications list procedure code, which are used to capture interventional data. These diagnosis and procedure codes are used by health care providers, government health programs, private health insurance companies, workers' compensation carriers, software developers, and others for a variety of applications in medicine, public health and medical informatics, including: statistical analysis of diseases and therapeutic actions reimbursement (e.g., to process claims in medical billing based on diagnosis-related groups) knowledge-based and decision support systems direct surveillance of epidemic or pandemic outbreaksThere are country specific standards and international classification systems. |
Holiline Reminder | Holiline Reminder is a free software calendar program for Windows. |
Ne (text editor) | ne (for "nice editor") is a console text editor for POSIX computer operating systems such as Linux or Mac OS X. It uses the terminfo library, but it can also be compiled using a bundled copy of the GNU termcap implementation. There is also a Cygwin version. It was developed by Sebastiano Vigna of the University of Milan. |
Meadery | A meadery is a winery or brewery that produces honey wines or meads, and which sells them commercially. There are craft "meaderies" emerging all over North America, Canada, Australia and New Zealand where each meadery produces various styles of meads, such as fruit meads, traditional meads, session meads, and braggots (mead-beer hybrids).Meaderies are becoming more commonplace around the world as people start to discover their offerings. Meaderies that produce honey wines or meads are becoming more abundant in the US. According to a study by the American Mead Maker Association, the community of mead producers has exploded 130% since 2011, making it the fastest growing alcoholic beverage category in the US.In the United Kingdom, particularly in Cornwall, a meadery can also refer to a type of restaurant that serves mead and food with a medieval ambience. An ancient meadery is thought to be in the style of a banquet hall, having wooden flooring, heavy wooden tables, and lit by candlelight with white-painted granite walls. |
Landau (automobile) | Landau is a carriage design with a folding fabric top consisting of two sections supported by external elliptical springs. When used in referencing an automobile, landau generally means a simulated convertible.The Nash Rambler Landau introduced in 1950 is a cabrio coach with a power-operated fabric top.A landau bar is an ornamental feature located on a car's rear quarter panel, mostly used on hearses. |
Rover Environmental Monitoring Station | Rover Environmental Monitoring Station (REMS) is a weather station on Mars for Curiosity rover contributed by Spain and Finland. REMS measures humidity, pressure, temperature, wind speeds, and ultraviolet radiation on Mars. This Spanish project is led by the Spanish Astrobiology Center and includes the Finnish Meteorological Institute as a partner, contributing pressure and humidity sensors. |
Quisqualic acid | Quisqualic acid is an agonist of the AMPA, kainate, and group I metabotropic glutamate receptors. It is one of the most potent AMPA receptor agonists known. It causes excitotoxicity and is used in neuroscience to selectively destroy neurons in the brain or spinal cord. Quisqualic acid occurs naturally in the seeds of Quisqualis species.
Research conducted by the USDA Agricultural Research Service, has demonstrated quisqualic acid is also present within the flower petals of zonal geranium (Pelargonium x hortorum) and is responsible for causing rigid paralysis of the Japanese beetle. Quisqualic acid is thought to mimic L-glutamic acid, which is a neurotransmitter in the insect neuromuscular junction and mammalian central nervous system. |
Paradiastole | Paradiastole (from Greek παραδιαστολή from παρά para "next to, alongside", and διαστολή diastole "separation, distinction") is the reframing of a vice as a virtue, often with the use of euphemism, for example, "Yes, I know it does not work all the time, but that is what makes it interesting." It is often used ironically. Paradiastole has been described as "the rhetorical technique of evaluative redescription -- more popularly known as euphemism and dysphemism -- designed to enlarge or reduce the moral significance of something". Another example is referring to manual labour as a "workout". Perhaps the most familiar usage today comes from the software world: "It's not a bug; it's a feature!" (This is used both euphemistically and literally, as many features in software originated as bugs). |
Singular they | Singular they, along with its inflected or derivative forms, them, their, theirs and themselves (also themself, and theirself), is a gender-neutral third-person pronoun. It typically occurs with an indeterminate antecedent, in sentences such as: "Somebody left their umbrella in the office. Could you please let them know where they can get it?" "My personal rule is to never trust anyone who says that they had a good time in high school." "The patient should be told at the outset how much they will be required to pay." "But a journalist should not be forced to reveal their sources."This use of singular they had emerged by the 14th century, about a century after the plural they. It has been commonly employed in everyday English ever since and has gained currency in official contexts. Singular they has been criticised since the mid-18th century by prescriptive commentators who consider it an error. Its continued use in modern standard English has become more common and formally accepted with the move toward gender-neutral language. Some early-21st-century style guides described it as colloquial and less appropriate in formal writing. However, by 2020, most style guides accepted the singular they as a personal pronoun.In the early 21st century, use of singular they with known individuals emerged for people who do not identify as male or female, as in, for example, "This is my friend, Jay. I met them at work." They in this context was named Word of the Year for 2015 by the American Dialect Society, and for 2019 by Merriam-Webster. In 2020, the American Dialect Society also selected it as Word of the Decade for the 2010s. |
Permanganate | A permanganate () is a chemical compound with the manganate(VII) ion, MnO−4, the conjugate base of permanganic acid. Because the manganese atom has a +7 oxidation state, the permanganate(VII) ion is a strong oxidising agent. The ion is a transition metal ion with a tetrahedral structure. Permanganate solutions are purple in colour and are stable in neutral or slightly alkaline media. The exact chemical reaction depends on the carbon-containing reactants present and the oxidant used. For example, trichloroethane (C2H3Cl3) is oxidised by permanganate ions to form carbon dioxide (CO2), manganese dioxide (MnO2), hydrogen ions (H+), and chloride ions (Cl−). |
AnyKode Marilou | anyKode Marilou is a modeling and simulation environment for mobile robots, humanoids, articulated arms and parallel robots operating in real-world conditions that respect the laws of physics. This robotics suite is used in research centers and industry for various projects like humanoid architectures, wheeled and multi legged vehicles, and multi-robot systems (Multi-agents).
It also has a real-time engine that uses the ODE (Open Dynamics Engine) for collisions detecting and dynamics management. Various 'real world' variables like forces, torques, masses, damping, friction and others can be adjusted directly to the objects surfaces. |
Anomalous oxygen | Anomalous oxygen is hot atomic and singly ionized oxygen believed to be present in Earth's exosphere above 500 km near the poles during their respective summers. This additional component augmenting mainly the hydrogen and helium exosphere is able to explain the unexpectedly high drag forces on satellites passing near the poles in their summers. Anomalous oxygen densities are included in the NRLMSISE-00 models of Earth's atmosphere. |
Sandalore | Sandalore is a synthetic sandalwood odorant with odor in some ways similar to sandalwood and consequently used in perfumes, emollients, and skin cleaning agents. Sandalore, and the similar brahmanol, have been identified as agonists of the cutaneous olfactory receptor OR2AT4, and found to induce strong Ca2+ signals in cultured human keratinocytes. The long-term stimulation of keratinocytes with Sandalore positively affected cell proliferation and migration, and regeneration of keratinocyte monolayers in an in vitro wound scratch assay (i.e., sandalore stimulation also enhanced epidermal "wound healing" in human skin organ cultures). Natural sandalwood oil and other synthetic sandalwood odorants did not have the same effect. |
Anti-NMDA receptor encephalitis | Anti-NMDA receptor encephalitis is a type of brain inflammation caused by antibodies. Early symptoms may include fever, headache, and feeling tired. This is then typically followed by psychosis which presents with false beliefs (delusions) and seeing or hearing things that others do not see or hear (hallucinations). People are also often agitated or confused. Over time, seizures, decreased breathing, and blood pressure and heart rate variability typically occur. In some cases, patients may develop catatonia.About half of cases are associated with tumors, most commonly teratomas of the ovaries. Another established trigger is herpesviral encephalitis, while the cause in others cases is unclear. The underlying mechanism is autoimmune, with the primary target being the GluN1 subunit of the N-methyl D-aspartate receptors (NMDAR) in the brain. Diagnosis is typically based on finding specific antibodies in the cerebral spinal fluid. MRI of the brain is often normal. Misdiagnosis is common.Treatment is typically with immunosuppresive medication and, if a tumor is present, surgery to remove it. With treatment, about 80% of cases have a good outcome. Outcomes are better if treatment is begun earlier. Long-term mental or behavioral problems may remain. About 4% of those affected die from the condition. Recurrence occurs in about 10% of people.The estimated number of cases of the disease is one in 1.5 million people per year. The condition is relatively common compared to other paraneoplastic disorders. About 80% of those affected are female. It typically occurs in adults younger than 45 years old, but it can occur at any age. The disease was first described by Josep Dalmau in 2007. |
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