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"although the clinical development of immune checkpoint inhibitors icis therapy has ushered in a new era of antitumor therapy with sustained responses and significant survival advantages observed in multiple tumors mostpatients do not benefit therefore more and more attention has been paid to the identification and dev... | Colon_Cancer |
"introduction a diet low in fermentable oligosaccharides disaccharides monosaccharides and polyols fodmap is an effective way to reduce gut symptoms in people with irritable bowel syndrome ibs this diet reduces the intake of fermentable fibres leading to changes of the gut microbiota and insufficient fermentation in t... | Colon_Cancer |
"colorectal cancer crc remains the third most prevalent cancer type and leading cause of cancerrelated deaths with million cases and deaths worldwide during the occurrence and progression of crc result from a wide array of cellular transformation processes which include genetic and epigenetic mut... | Colon_Cancer |
"colorectal cancer crc remains the third most prevalent cancer type and leading cause of cancerrelated deaths with million cases and deaths worldwide during the occurrence and progression of crc result from a wide array of cellular transformation processes which include genetic and epigenetic mut... | Colon_Cancer |
recently extensive evidence has clarified the crucial role of circular rnas circrnas as a protumor or anticancer participant in human malignancies a new circrna derived from oxysterol binding protein like osbpl10 circosbpl10 has not been researched in cervical cancer cc yetmethods the expression of molecules was ... | Colon_Cancer |
" gastric neoplasms containing neuroendocrine carcinoma nec components are rare malignancieswith highly aggressive behavior and a poor prognosis and include pure nec and mixed tumors containing neccomponents we aimed to investigate whether there is a distinct difference in overall survival os between gastricneoplasms ... | Colon_Cancer |
thyroid carcinoma is presently the malignancy with the most rapidly increasing incidence in the worldand is the most widely recognized endocrine carcinoma in the western world thyroid cancers derivedfrom follicular thyroid cells can be sorted into papillary thyroid carcinoma ptc follicular thyroid carcinoma ftc and a... | Colon_Cancer |
bcl9 and pygo are bcatenin cofactors that enhance the transcription of wnt targetgenes they have been proposed as therapeutic targets to diminish wnt signaling output inintestinal malignancies here we find that in colorectal cancer cells and in developing mouseforelimbs bcl9 proteins sustain the action of bcatenin in ... | Colon_Cancer |
during the covid19 pandemic emergency departments have noted a significant decrease in strokepatients we performed a timely analysis of the bavarian telestroke tempis working diagnosis databasemethods twelve hospitals from the tempis network were selected data collected for january through april in years through we... | Colon_Cancer |
coronaviruses covs belong to a family of envelopedviruses with a positive sense singlestranded rna genomecovs cause illness ranging from upper respiratory tractinfections urtis resembling the common cold to lowerrespiratory tract infections lrtis such as bronchitis pneumonia and even severe acute respiratory syndrome s... | Colon_Cancer |
as one of the most common gynecological malignant tumors cervical cancer is the fourth leadingcause of cancerrelated death among women worldwide although eï¬orts including periodiccancer screening prompt surgical treatment chemotherapy and radiotherapy have been madeto decrease the mortality of cervical cancer the pro... | Colon_Cancer |
" mutations in the wilms tumor gene cause a spectrum of podocytopathy ranging from diffusemesangial sclerosis to focal segmental glomerulosclerosis in a considerable fraction of patients with wilms tumor mutations the distinctive histology of immunecomplextype glomerulonephritis has been reported however theclinical ... | Colon_Cancer |
cancer stem cells cscs are important factors contributing to tumorigenesiswe examined whether cscs isolated from colorectal cancer crc cells possessmetastatic properties that can be transferred to noncscs via the deliveryof mir200c enclosed in extracellular vesicles evs the inhibitory effectof atractylenolide i atl1 a ... | Colon_Cancer |
objective cannabinoids are able to reduce tumor growth in xenograft models but their therapeutic potential as anticancer drugs in humans is unclear yet in vitro studies of the effect of cannabinoids on cancer cells are often carried out in absence of serum or in low serum concentration ie serum conditions that lim... | Colon_Cancer |
colorectal cancer crc is one of the most common malignanttumors in china chen crc is one of the ï¬veleading causes of cancer death and its incidence is graduallyincreasing owing to obesity and lifestyle changes du chen postoperative treatments includingchemotherapy and radiotherapy are important for longer pat... | Colon_Cancer |
tetrastigma hemsleyanum diels et gilg t hemsleyanum mostly known as san ye qing is a kind of folk plant because of its slow growth it usually takes years to meet the requirements of commercial medicinal materials so it is a precious perennial medicinal resource it mainly grows in the eastern centra... | Colon_Cancer |
" a critical barrier to improving the quality of endoflife eol cancer care is our lack of understanding of themechanisms underlying variation in eol treatment intensity this study aims to fill this gap by identifying anizational and provider practice norms at major us cancer centers and how these norms influence prov... | Colon_Cancer |
"adipogenesis is the process through which mesenchymalstem cells mscs commit to the adipose lineage and diï¬erentiate into adipocytes during this process preadipocytescease to proliferate begin to accumulate lipid droplets anddevelop morphologic and biochemical characteristics ofmature adipocytes such as hormonerespons... | Colon_Cancer |
" when we encounter patients who present with both a neck mass and nephrotic syndrome bothmalignancy and kimuras disease need to be evaluated as the therapeutic strategies differ vastly between themcase presentation we present the case of a 27yearold male patient with neck mass and nephrotic syndromethe presence of b... | Colon_Cancer |
"adipogenesis is the process through which mesenchymalstem cells mscs commit to the adipose lineage and diï¬erentiate into adipocytes during this process preadipocytescease to proliferate begin to accumulate lipid droplets anddevelop morphologic and biochemical characteristics ofmature adipocytes such as hormonerespons... | Colon_Cancer |
gastroenteropancreatic neuroendocrine neoplasms gep nens as well as neuroendocrine tumors gep nets are heterogeneous tumors that originate from peptidergic neurons and neuroendocrine cells previously described as carcinoid tumors in most nets are indolent tumors compared with other epithelial malignancies h... | Colon_Cancer |
recently extensive evidence has clarified the crucial role of circular rnas circrnas as a protumor or anticancer participant in human malignancies a new circrna derived from oxysterol binding protein like osbpl10 circosbpl10 has not been researched in cervical cancer cc yetmethods the expression of molecules was ... | Colon_Cancer |
" prognostic markers play an essential role in the proper management of communityacquiredpneumonia this research work aimed to evaluate the association of rdw and or mpv with mortality andmorbidity in patients with cap to improve the yield of already used prognostic scoresresults the current study enrolled patients w... | Colon_Cancer |
" inflammatory pseudotumour has been used to describe an inflammatory or fibrosing tumoral processof an undetermined cause that may involve a variety of an systems including the lungs spleen liver lymphnodes pancreas and extrahepatic bile duct with potential for recurrence and persistent local growth in this we report... | Colon_Cancer |
microbiota involves communities ofhepatitis is generally known as an ammation of the liver that can be caused by hepaticand nonhepatic viruses can be caused by alcohol can be drug induced and can be caused byautoimmunity gut microbiota composition is known to be associated with disease pathogenesishowever dynamic alte... | Colon_Cancer |
"the kinetics and localization of the reactions of metabolism are coordinated by the enzymes that catalyze themthese enzymes are controlled via a myriad of mechanisms including inhibitionactivation by metabolitescompartmentalization thermodynamics and nutrient sensingbased transcriptional or posttranslational regulatio... | Colon_Cancer |
" microwave ablation mwa is widely used to treat unresectable primary and secondary malignanciesof the liver and a limited number of studies indicate that ablation can cause not only necrosis at the in situ site butalso an immunoreaction of the whole body this study aimed to investigate the effects of mwa on cytokines... | Colon_Cancer |
"gut microbiota composition influences the balance between human health and disease increasing evidencesuggests the involvement of microbial factors in regulating cancer development progression and therapeuticresponse distinct microbial species have been implicated in modulating gut environment and architecture thataff... | Colon_Cancer |
gon§ales junior w effect of treatment with injectable progesterone at the onset of super precocious tairessincronization protocol on tai pregnancy rates of nellore heifers in animal reproduction for the annual meeting of the brazilian embryo technology society sbte august florianopolis brazil animal reproducti... | Colon_Cancer |
the heterogeneity of cancer cells is generally accepted and astem celllike subpopulation that is called cancer stem cellscscs has been identiï¬ed in various types of malignanttumors although the lack of consensus on the deï¬nitioncscs are widely recognized as a small subpopulation amongcancer cells with the propert... | Colon_Cancer |
the introduction of combined conventional cytostatics and pathwayspecific inhibitors has opened new treatment options for several cancer types including hematologic neoplasia such as leukaemias as the detailed understanding of the combinationinduced molecular effects is often lacking the identification of combina... | Colon_Cancer |
" the empirical dietary index for hyperinsulinemia edih score is a validated foodbased dietary scorethat assesses the ability of wholefood diets to predict plasma cpeptide concentrations although the edih hasbeen extensively applied and found to be predictive of risk of developing major chronic diseases its influence ... | Colon_Cancer |
several immunotherapeutic strategies that harness the exquisite speciï¬city of the immune systemto eliminate tumors have emerged during the past decade these include cancer vaccines immunecheckpoint blockade and adoptive cell therapy act with the potential to revolutionize thestandard of care for a range of malignanc... | Colon_Cancer |
microbiota involves communities ofhepatitis is generally known as an ammation of the liver that can be caused by hepaticand nonhepatic viruses can be caused by alcohol can be drug induced and can be caused byautoimmunity gut microbiota composition is known to be associated with disease pathogenesishowever dynamic alte... | Colon_Cancer |
" microwave ablation mwa is widely used to treat unresectable primary and secondary malignanciesof the liver and a limited number of studies indicate that ablation can cause not only necrosis at the in situ site butalso an immunoreaction of the whole body this study aimed to investigate the effects of mwa on cytokines... | Colon_Cancer |
the world health anization who indicated thatliver cancer was the sixth mostcommon cancer and the fourth leading cause of cancer deaths worldwide in witha global death toll of the risk factors for liver cancer include hepatitisb hepatitis c alcoholic liver disease nonalcoholic fatty liver disease and cirrhosis at p... | Colon_Cancer |
environmental exposure to arsenite as3 has a strong association with the development ofhuman urothelial cancer uc and is the 5th most common cancer in men and the 12th mostcommon cancer in women muscle invasive urothelial cancer miuc are grouped into basalor luminal molecular subtypes based on their gene expression pro... | Colon_Cancer |
"piglet diarrhea is one of the most severe diseases aï¬ictingpiglets leading to their delayed growth and developmentlow feed returns and even death which has seriously damaged the economic development of pig industries globally recently clostridium perfringens the important pathogenic microanism that causes diarrhea ... | Colon_Cancer |
" mutations in the exonuclease domain of pole a dna polymerase associated with dna replicationand repair lead to cancers with ultrahigh mutation rates most studies focus on intestinal and uterine cancers withpole mutations these cancers exhibit a significant immune cell infiltrate and favorable prognosis we questioned... | Colon_Cancer |
" tumor mutational burden tmb has both prognostic value in resected nonsmall cell lung cancernsclc patients and predictive value for immunotherapy response however tmb evaluation by wholeexomesequencing wes is expensive and timeconsuming hampering its application in clinical practice in our study weaimed to construct ... | Colon_Cancer |
" rectus sheath block rsb is known to attenuate postoperative pain and reduce perioperative opioidconsumption thus a retrospective study was performed to examine the effects of bilateral rectus sheath blockbrsb in cytoreductive surgery crs combined with hyperthermic intraperitoneal chemotherapy hipecmethods a total of... | Colon_Cancer |
biochemically interleukin6 belongs to the class of fourhelical cytokines the cytokine can be synthesised and secreted by many cells it acts via a cell surfaceexpressed interleukin6 receptor which is not signalling competent this receptor when complexed with interleukin6 associates with the signalling receptor glycopro... | Colon_Cancer |
" recent impressive advances in cancer immunotherapy have been largely derived from cellular immunity the role of humoral immunity in carcinogenesis has been less understood based on our previous observations we hypothesize that an immunoglobulin subtype igg4 plays an essential role in cancer immune evasionmethods t... | Colon_Cancer |
" immune checkpoint inhibitors that block programmed cell death1 pd1 and programmed cell death ligand1 pd l1 have improved outcomes for many cancer subtypes but do exhibit toxicity in the form of immune related adverse eventsobjective the aim of this study was to investigate the emerging toxicities of pd1 and pd l1 ... | Colon_Cancer |
"protein phosphatase 2a pp2a is a serinethreonine phosphatase that serves as a key regulator of cellularphysiology in the context of apoptosis mitosis and dna damage responses canonically pp2a functions as atumor suppressor gene however recent evidence suggests that inhibiting pp2a activity in tumor cells mayrepresent ... | Colon_Cancer |
craigpattersontelecaretoj rajani r perry m the reality of medical work the case for a new perspectiveon telemedicine virtual real bf01421807 hoek pd schers hj bronkhorst em vissers kcp hasselaar jgj the eï¬ectof weekly specialist palliative care teleconsultations in patients with advancedcancer a randomized clini... | Colon_Cancer |
" lung carcinoma is a prominent cause of mortality among patients with cancer previous studies have reported the vital role of long noncoding rnas lncrnas in the malignant progression of lung cancer lncrna rp11284f219 was originally identified to be expressed in lung carcinoma but its specific function remains unknown ... | Colon_Cancer |
"it is well understood that the level of molecular oxygen o2 in tissue is a very important factor impacting both physiology and pathological processes as well as responsiveness to some treatments data on o2 in tissue could be effectively utilized to enhance precision medicine however the nature of the data that can be ... | Colon_Cancer |
"objectives therapeutic radiographers trs are well placed to deliver health behaviour change advice to those living with and beyond cancer lwbc however there is limited research on the opinions of trs around delivering such advice to those lwbc this study aimed to explore trs practices and facilitators in delivering ... | Colon_Cancer |
nasopharyngeal carcinoma npc is an epithelial malignancy with high morbidity rates in the east and southeast asia the molecular mechanisms of npc remain largely unknown we explored the pathogenesis potential biomarkers and prognostic indicators of npcmethods we analyzed mrnas long noncoding rnas lncrnas and micror... | Colon_Cancer |
"carcinogenesis is a process of somatic evolution previous models of stem and transient amplifying cells in epithelial proliferating units like colonic crypts showed that intermediate numbers of stem cells in a crypt should optimally prevent progression to cancer if a stem cell population is too small it is easy for a ... | Colon_Cancer |
lenvatinib inhibits tyrosine kinases including vascular endothelial growth factor vegf receptor fibroblast growth factor receptor platelet derived growth factor receptor alpha ret proto oncogene and kit proto oncogene receptor tyrosine kinase we assessed the efficacy and safety of lenvatinib in patients with metasta... | Colon_Cancer |
objective cannabinoids are able to reduce tumor growth in xenograft models but their therapeutic potential as anticancer drugs in humans is unclear yet in vitro studies of the effect of cannabinoids on cancer cells are often carried out in absence of serum or in low serum concentration ie serum conditions that lim... | Colon_Cancer |
bcl9 and pygo are bcatenin cofactors that enhance the transcription of wnt targetgenes they have been proposed as therapeutic targets to diminish wnt signaling output inintestinal malignancies here we find that in colorectal cancer cells and in developing mouseforelimbs bcl9 proteins sustain the action of bcatenin in ... | Colon_Cancer |
ammation is an established risk factor for colorectal cancer we and others have shown that colorectal cancerpatients with elevated cysteinyl leukotriene receptor cyslt2r and 15hydroxyprostaglandin dehydrogenase15pgdh levels exhibit good prognoses however both cyslt2r and 15pgdh which act as tumour suppressorsare ofte... | Colon_Cancer |
to probiotics general attitudes and functions since the first observation of probiotic bacteria by elie metchnikoff there have been several studies on the immunological effects of probiotics on the host immune system according to who and fao probiotics are defined as live microanisms which when administered in proper... | Colon_Cancer |
to the human gut microbiota biochem taxonomic hierarchy of the phylum firmicutes and novel firmicutes species originated from various environments in korea j microbiol front microbiol filippidou s a combination of extreme environmental conditions favor the prevalence of endosporeforming firmicutes bints... | Colon_Cancer |
several immunotherapeutic strategies that harness the exquisite speciï¬city of the immune systemto eliminate tumors have emerged during the past decade these include cancer vaccines immunecheckpoint blockade and adoptive cell therapy act with the potential to revolutionize thestandard of care for a range of malignanc... | Colon_Cancer |
covid19 has had an impact on the provision of colorectal cancer care the aim of the crccovid study is to describe the changes in colorectal cancer services in the uk and usa in response to thepandemic and to understand the longterm impactmethods and analysis this study comprises phases phase is a survey of colorecta... | Colon_Cancer |
overexpression of epithelial cell adhesion molecule epcam has been associated with chemotherapeutic resistanceleads to aggressive tumor behavior and results in an adverse clinical outcome the molecular mechanism by whichepcam enrichment is linked to therapeutic resistance via nrf2 a key regulator of antioxidant genes i... | Colon_Cancer |
" the incidence of thyroid carcinoma is increasing all over the world some studies have suggestedthat the change of adipokines expression can induce thyroid carcinoma however other studies have come to theopposite therefore we studied the relationship between adipokines and thyroid carcinomamethods databasespubmed c... | Colon_Cancer |
environmental exposure to arsenite as3 has a strong association with the development ofhuman urothelial cancer uc and is the 5th most common cancer in men and the 12th mostcommon cancer in women muscle invasive urothelial cancer miuc are grouped into basalor luminal molecular subtypes based on their gene expression pro... | Colon_Cancer |
despite great advances in recent decades in screening diagnosisand curative surgery hepatocellular carcinoma hcc remainsthe second leading cause of cancerrelated mortality worldwidegrandhi siegel epidemiologicalevidence has conï¬rmed that the longterm outcomes of patientswith hcc have notimproved significantly w... | Colon_Cancer |
" micrornas mirnas have been reported to have important regulatory roles in the progression of several types of cancer including cervical cancer cc however the biological roles and regulatory mechanisms of mirnas in cc remain to be fully elucidated the aim of the present study was to examine the functions of mirnas in ... | Colon_Cancer |
the bacteroides fragilis b fragilis produce biofilm for colonisation in the intestinal tract can cause a series of inflammatory reactions due to b fragilis toxin bft which can lead to chronic intestinal inflammation and tissue injury and play a crucial role leading to colorectal... | Colon_Cancer |
alcoholic liver disease ald is a chronic alcoholinduced disorder of the liver for which there are few effectivetherapies for severe forms of ald and for those who do not achieve alcohol abstinence in this study we used asystematic drugrepositioning bioinformatics approach querying a large compendium of geneexpression p... | Colon_Cancer |
" although rnabinding proteins play an essential role in a variety of different tumours there are stilllimited efforts made to systematically analyse the role of rnabinding proteins rbps in the survival of colorectalcancer crc patientsmethods analysis of crc transcriptome data collected from the tcga database was cond... | Colon_Cancer |
pancreatic cancer is a devastating malignancy with a 5year relative survival rate of only dependenton the geographical location surveyed [] with these statistics exhibiting only modest improvementover the last four decades [] the median survival postdiagnosis ranges from just months forlocally advanced disease an... | Colon_Cancer |
alcoholic liver disease ald is a chronic alcoholinduced disorder of the liver for which there are few effectivetherapies for severe forms of ald and for those who do not achieve alcohol abstinence in this study we used asystematic drugrepositioning bioinformatics approach querying a large compendium of geneexpression p... | Colon_Cancer |
" oral administration is the most common way to deliver drugs to the systemic circulation or targetans orally administered drugs are absorbed in the intestine and metabolized in the intestine and liver in theearly stages of drug development it is important to predict firstpass metabolism accurately to select candidate... | Colon_Cancer |
" trophoblast cell surface antigen trop2 is overexpressed in many squamous cell carcinomas andpromotes tumor development and invasion the association between trop2 expression and occurrence anddevelopment of oral squamous cell carcinoma oscc remains to be understoodmethods we investigated the role of trop2 in oscc pa... | Colon_Cancer |
" breast cancer bc is the most commonly diagnosed malignant cancer in women bc is the main cause of cancerrelated death in women and seriously threatens the life and health of women worldwide micrornas mirnasmirs have been reported to regulate the development and progression of different types of cancer however the reg... | Colon_Cancer |
"eph receptors and the corresponding eph receptorinteracting ephrin ligands jointly constitute a critical cellsignaling network that has multiple functions the tyrosine kinase epha2 which belongs to the family of ephreceptors is highly produced in tumor tissues while found at relatively low levels in most normal adult ... | Colon_Cancer |
" healthcare is an essential service at any time more so in the crisis like covid with increase in numberof cases and mortality from covid the primary focus is shifted to the management of the covid crisis and otherhealth emergencies thus affecting normal health services and routine treatment of other diseases like ca... | Colon_Cancer |
" leukotriene receptor antagonists ltras are broadly used for the management of allergic asthmaand have recently been indicated to inhibit carcinogenesis and cancer cell growth in colorectal cancer crcchemoprevention studies the occurrence of adenoma or crc itself is generally set as the trial endpoint althoughthe occ... | Colon_Cancer |
purposeconjunctival squamous cell carcinoma scc is primarily treated with surgical resectionscc has various stages and local recurrence is common the purpose of this study was todetermine molecular localization of epidermal growth factor receptor egfr and the possibility of egfr as a biomarker for the management of con... | Colon_Cancer |
chronic respiratory diseases are highly prevalent worldwide and will continue to rise in theforeseeable future despite intensive efforts over recent decades the development of novel and effectivetherapeutic approaches has been slow however there is new and increasing evidence that communities ofmicroanisms in our body... | Colon_Cancer |
the european commission asked efsa for a scientiï¬c opinion on the risks for animal and humanhealth related to the presence of glycoalkaloids gas in feed and food this risk assessment coversedible parts of potato plants and other food plants containing gastomato andaubergine in humans acute toxic effects of potato gas... | Colon_Cancer |
] we have filtered only research s published in english language and selected the following keywords air pollution and covid19 or sarscov2 particulate matter or pm and covid19 or sarscov2 nitrogen dioxide or no2 and covid19 or sarscov2 we choose as inclusion criteria all the available epidemiological st... | Colon_Cancer |
neutrophils account for of circulating leukocytes and are the ï¬rst immune cells recruitedto an ammatory site they play an important role in the innate immune response topathogens as patients with neutropenia are highly susceptible to bacterial and fungal infections neutrophils perform numerous functions that targe... | Colon_Cancer |
" pharmacology and toxicology laboratory csirinstitute of himalayan bioresource technology preproof 0c preproofinfection f0b7 systemic oxidative stress and inflammation are significant outcomes of sarscov2 highlights f0b7 activated gsk3 following sarscov2 infection provoke the oxidative stress and inflammati... | Colon_Cancer |
" immune checkpoint inhibitors that block programmed cell death1 pd1 and programmed cell death ligand1 pd l1 have improved outcomes for many cancer subtypes but do exhibit toxicity in the form of immune related adverse eventsobjective the aim of this study was to investigate the emerging toxicities of pd1 and pd l1 ... | Colon_Cancer |
open accesscitation iburg km mikkelsen l adair t lopez ad are cause of death data fit for purposeevidence from countries at different levels ofsocioeconomic development one e0237539 101371 pone0237539editor brecht devleesschauwer sciensanobelgiumreceived april accepted july published august peer review history re... | Colon_Cancer |
esophageal cancer ec is the eight commonest type of worldwide cancer and the sixth leading gastrointestinal malignancy with a poor survival rate which is caused by many factors such as tobaccosmoking heavy drinking lack of fruits and vegetables and there are two main histological types of ecesophageal adenocarcinoma ... | Colon_Cancer |
" drug resistance leads to tumor relapse and further progression during chemotherapy in lung cancer close homolog of l1 chl1 has been identified as a tumor suppressor in most malignancies however to the best of our knowledge whether chl1 mediates chemoresistance remains unknown the present study observed that chl... | Colon_Cancer |
"pd1pdl1 blockade therapy is a promising cancer treatment strategy which has revolutionized the treatmentlandscape of malignancies over the last decade pd1pdl1 blockade therapy has been trialed in a broad range ofmalignancies and achieved clinical success despite the potentially curelike survival benefit only a minorit... | Colon_Cancer |
" fasassociated factor faf1 has been implicated in parkinsons disease pd and activates the celldeath machinery in the cytosol however the presence of extracellular faf1 has not been studiedmethods serumfree conditioned medium cm from faf1transfected shsy5y cells was concentrated andanalyzed by western blotting exoso... | Colon_Cancer |
lenvatinib inhibits tyrosine kinases including vascular endothelial growth factor vegf receptor fibroblast growth factor receptor platelet derived growth factor receptor alpha ret proto oncogene and kit proto oncogene receptor tyrosine kinase we assessed the efficacy and safety of lenvatinib in patients with metasta... | Colon_Cancer |
] we have filtered only research s published in english language and selected the following keywords air pollution and covid19 or sarscov2 particulate matter or pm and covid19 or sarscov2 nitrogen dioxide or no2 and covid19 or sarscov2 we choose as inclusion criteria all the available epidemiological st... | Colon_Cancer |
" the popularization of health and medical informatics yields huge amounts of data extracting clinicalevents on a temporal course is the foundation of enabling advanced applications and research it is a structure ofpresenting information in chronological order manual extraction would be extremely challenging due to th... | Colon_Cancer |
" chronic colorectal inflammation has been associated with colorectal cancer crc however its exact molecular mechanisms remain unclear the present study aimed to investigate the effect of tolllike receptor tlr9 on the development of colitisassociated crc cac through its regulation of the nfκb signaling pat... | Colon_Cancer |
"purpose squamous cell carcinomas and adenocarcinomas are the most common types of cervical cancercompared to squamous cell carcinomas adenocarcinomas are more common in younger women and have apoorer prognosis yet so far no useful biomarkers have been developed for these two types of cancer in thefollowing study we ex... | Colon_Cancer |
bcl9 and pygo are bcatenin cofactors that enhance the transcription of wnt targetgenes they have been proposed as therapeutic targets to diminish wnt signaling output inintestinal malignancies here we find that in colorectal cancer cells and in developing mouseforelimbs bcl9 proteins sustain the action of bcatenin in ... | Colon_Cancer |
"eph receptors and the corresponding eph receptorinteracting ephrin ligands jointly constitute a critical cellsignaling network that has multiple functions the tyrosine kinase epha2 which belongs to the family of ephreceptors is highly produced in tumor tissues while found at relatively low levels in most normal adult ... | Colon_Cancer |
cancer is the second leading cause of death in the united states cancer screenings candetect precancerous cells and allow for earlier diagnosis and treatment our purpose was tobetter understand risk factors for cancer screenings and assess the effect of cancer screenings on changes of cardiovascular health cvh measure... | Colon_Cancer |
although autophagy plays a dual role in suppressing or promoting certain cancers the nature of its involvement in breast cancers remainsunclear here we investigated the function of stxbp6 a protein regulating theautophagyassociated snare complex in triple negative breast cancer tnbcresults we report that stxbp6 is pr... | Colon_Cancer |
"circadian clocks have important physiological and behavioral functions in humans and other anisms whichenable anisms to anticipate and respond to periodic environmental changes disturbances in circadian rhythmsimpair sleep metabolism and behavior people with jet lag night workers and shift workers are vulnerable tocir... | Colon_Cancer |
" variability in the health effects of dietary fiber might arise from interindividual differences in the gutmicrobiotas ability to ferment these substrates into beneficial metabolites our understanding of what drives thisindividuality is vastly incomplete and will require an ecological perspective as microbiomes func... | Colon_Cancer |
the european commission asked efsa for a scientiï¬c opinion on the risks for animal and humanhealth related to the presence of glycoalkaloids gas in feed and food this risk assessment coversedible parts of potato plants and other food plants containing gastomato andaubergine in humans acute toxic effects of potato gas... | Colon_Cancer |
" heat shock transcription factor1 hsf1 was overexpressed to promote glutaminolysis and activatemtor in colorectal cancer crc here we investigated the mechanism for cancerspecific overexpression of hsf1methods hsf1 expression was analyzed by chromatin immunoprecipitation qrtpcr immunohistochemistrystaining and immunob... | Colon_Cancer |
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