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39 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Total testosterone level <240 ng/dL
- Serum LH and FSH levels within normal limits
Exclusion Criteria:
- Elevated prolactin
- Evidence of Benign Prostatic Hypertrophy
- History of or current breast cancer, prostate cancer, abnorm... | A Preliminary Clinical Study to Evaluate Fispemifene in the Treatment of Hypogonadism | NCT00290134 | Contradiction |
4,274 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Patients who can perform lung function tests and who can produce sputum (> 5 years of
age)
- (Fe)males between 6-64 years
Exclusion Criteria:
- Patients on the waiting lists for lung transplant.
- Pregnancy or breast feeding
... | The Effect of Inhaled N-Acetylcysteine Compared to Normal Saline on Sputum Rheology and Lung Function | NCT00996424 | Entailment |
2,520 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
1. Healthy, female or male infants/children, aged 6 months through 7 years.
2. In generally good health (physical, mental, and social well-being, not merely the
absence of disease/infirmity), according to parent/legal guardian report.
3. Having Fitzpatri... | A Clinical Study to Evaluate the Safety and Efficacy of a Baby Cleanser and a Moisturizer | NCT03719742 | Entailment |
1,970 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. The patient has histologically or cytologically confirmed gastric carcinoma, including
gastric adenocarcinoma or GEJ adenocarcinoma. (Patients with adenocarcinoma of the
distal esophagus are eligible if the primary tumor involves the GEJ.)
2. The pa... | Ramucirumab/Paclitaxel as Second-line Treatment in Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma With Integrative Genomic Analysis | NCT02628951 | Entailment |
4,334 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
1. Male subjects in the range of age from 18 to 55 years.
2. Body weight within ± 15% of ideal weight as related to height and body frame according
to Life Insurance Corporation (LIC) Chart. (Appendix A)
3. Subjects with normal findings as determined by ... | Bioequivalence Study of Tacrolimus 1 mg Capsule Under Fed Condition | NCT01080469 | Contradiction |
2,390 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- children with Duchenne muscular dystrophy (DMD). Diagnosis with DMD was established
according to DMD diagnostic criteria (Jennekens et al., 1991).
- children with juvenile dermatomyositis (JDM) according to Bohan and Peter diagnostic
criteria ( (Bo... | Quantitative Muscle Ultrasound as a Marker of Progression in Children With Muscular Diseases | NCT03786913 | Entailment |
1,519 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- History of hypertension
- At least one blood pressure value that is greater than recommended in the year prior
to study entry
- An enrolled physician has provided care for managing the participant's blood pressure
for at least 1 year pr... | Individually Tailored Web-Based Program to Improve Blood Pressure Control | NCT00377208 | Entailment |
2,705 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Patients scheduled for elective laparoscopic abdominal surgeries (inguinal hernia
repair-missed IUCD extraction-appendectomy-ovarian vein ligation)
- Patient aged 18-60 years
- American Society of Anesthesiologists Physical Status I or II.
... | Lateral Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Laparoscopic Surgery | NCT04553991 | Entailment |
3,983 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Physician-diagnosed mild to moderate knee osteoarthritis (OARSI atlas grades 1-2)
based on fixed-flexion x-ray radiological findings for osteophytes and joint space
narrowing within the past 12 months
- Fulfill the American College of Rheumatology ... | Wearable LITUS Device for Osteoarthritis of the Knee: a Randomized Double-Blind Placebo-Controlled Trial | NCT02083861 | Entailment |
5,609 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria
- Member of a Girl Scout troop with at least eight 5th grade girls
- Member of the Greater Minneapolis or St. Croix Valley Girl Scout organization
- Only troops with unanimous parental consent will be included in the trial
Female
Accepts Healthy Volunteers
Subject ... | Program to Prevent Osteoporosis in Girls | NCT00063024 | Contradiction |
4,455 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion criteria
- Tendinopathy present in either lateral or medial elbow
- Pain by palpation at the lateral or medial epicondyle of the elbow
- Baseline elbow pain >3/10 during resisted wrist extension
- History of at least two periods of elbow pain lasting more than 1... | Platelet Rich Plasma (PRP) in Chronic Epicondylitis | NCT01945528 | Contradiction |
86 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- severely obese (BMI >= 35) male veterans with hypogonadotropic hypogonadism defined as
low total testosterone (lower than 300 ng/dl) between 35-65 years of age
- Luteinizing hormone (LH) lower than 9 U/L
- estradiol above 40 pmol/l
- nor... | Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot) | NCT02959853 | Contradiction |
3,634 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Historically lowest VWF:Ag and/or VWF:RCo and/or VWF:CB ≤ 0.30 IU/mL and/or FVIII:C ≤
0.40 IU/mL
- Treatment at a Hemophilia treatment center in the Netherlands
- All types of VWD
- All ages
Exclusion Criteria:
- Other ... | Von Willebrand Disease in the Netherlands | NCT03521583 | Entailment |
2,766 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
1. Age ≥ 18 year
2. Informed consent
3. a diagnosis of an inguinal hernia
4. ASA group ≤ 3
5. BMI ≤ 35
Exclusion Criteria:
1. Communication problems
2. No consent
3. Open procedure (not laparoscopic)
... | Ilioinguinal Block in Laparoscopic Inguinal Hernia Repair | NCT01969006 | Entailment |
2,494 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- All residents aged over 40 in Namil area
Exclusion Criteria:
- Individuals registered but not actually living in this area
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
| Screening for Glaucoma in Namil Area, South Korea | NCT00727168 | Entailment |
1,752 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- outpatients
- chief complaints of characteristic GERD symptoms (heart burn or acid regurgitation),
evaluated by standard questionnaire
- undergo upper digestive endoscopy
Exclusion Criteria:
- age less than 18 years old or more ... | Endoscopic Findings in Patients With Typical Gastroesophageal Reflux Disease (GERD) Symptoms | NCT00730106 | Contradiction |
2,940 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Able to comprehend and willing to sign an Informed Consent Form (ICF)
2. Male or female 18 years of age or older
3. A diagnosis of familial or sporadic ALS (defined as meeting the possible,
laboratory-supported probable, probable, or definite criteria... | Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS) | NCT01709149 | Entailment |
3,533 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Healthy male and female subjects aged 18-68 years, non-smokers or regular smokers of
greater than 6 cigarettes a day, BMI 16-29
- Male and female Cushing's syndrome aged 18-68 years with biochemically confirmed based
on cortisol and ACTH measuremen... | Dynamic Hormone Diagnostics in Endocrine Disease | NCT02934399 | Entailment |
2,878 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Subjects with diagnosed ALS by the revised El Escorial diagnostic criteria, including
laboratory supported probable, probable, or definite ALS;
2. Subjects who have never taken riluzole tablets, OR Subjects who previously took
riluzole tablets but d... | Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALS | NCT03520517 | Entailment |
999 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- all new patient present to AHNH clinic referred for osteoarthritis for considering
joint replacement
- Present with knee pain (unilateral or bilateral) contributed by osteoarthritis
Exclusion Criteria:
- mentally unsound
- diale... | Psychological Strengths and Burden Among Osteoarthritis Patient | NCT03899272 | Entailment |
1,792 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients undergoing the first upper gastrointestinal endoscopy.
Exclusion Criteria:
- The patients had previously performed endoscopy and any esophageal, gastric or
duodenal surgery.
- The patients couldn't complete the questionnaire survey... | Correlation of Endoscopic Findings and Symptoms in Patients Undergoing the First Upper Gastrointestinal Endoscopy | NCT03736824 | Contradiction |
5,509 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- patients with a first episode of biopsy and/or scintigraphy proven giant cell
arteritis
- patients with a previous diagnosis of giant cell arteritis, in whom a yearly computed
tomography of the aorta is available can opt to participate in this stud... | Prospective Follow-up Study of the Aortic Diameter in Patients With Giant Cell Arteritis | NCT01588483 | Entailment |
434 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age > 35 years
- Day 3 serum FSH level > 10m IU/ml
- Number of antral follicles measuring 4-8mm during the early phase < 6
- Small ovarian volume
- AMH < 1
- Prior poor ovarian response to COH (oocytes < 5)
Exclusion ... | Comparative Study Between Minidose Long Protocol and Microdose Flare Protocol in Controlled Ovarian Hyperstimulation | NCT02342197 | Contradiction |
1,780 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion criteria:
1. Aged 18 years and older;
2. Presence of dyspeptic symptoms according with Rome IV criteria (Discomfort was
characterized by the presence of one or more symptoms that included bothersome
postprandial fullness, bothersome early satiation, bothersome e... | The Predictive Value of Alarm Symptoms in Patients With Dyspepsia Based on Roman IV | NCT03479528 | Contradiction |
3,501 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Established autoimmune adrenal failure for >1yr age 16 to 65
Exclusion Criteria:
- Significant cardio-respiratory, chronic renal or non-autoimmune liver disease;
malignancy
- Asthma, current infectious disease, recent live vaccination, acut... | Revival of Stem Cells in Addison's Study | NCT01371526 | Contradiction |
864 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Joint pain related to daily activities;
- No morning joint stiffness greater than 30 minutes;
- Age between 30 and 95 years.
Exclusion Criteria:
- History of previous knee surgery.
- History of fracture in the knee region.
... | Effects of Sand Treatment on Osteoarthritis | NCT03943303 | Entailment |
157 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
Male, ages 18 to 65 Serum total testosterone less than or equal to 250 ng/dL Naive to
androgen replacement therapy Subject must be on stable doses of thyroid or adrenal
replacement hormones for at least 14 days prior to enrollment
Exclusion Criteria:
Signif... | Pilot Pharmacokinetic Study of Oral Testosterone Ester Formulations in Hypogonadal Men | NCT02697188 | Entailment |
4,481 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. A eumenorrheic healthy woman with a regular menstrual cycle for three months,
predictable, and a period between 24-38 days that lasts less than 8 days.
2. No hormonal contraceptives have been used in the past six months.
3. No history of smoking, drin... | A Two-stage Translation of the Chinese Version Menstrual Distress Questionnaire | NCT04452227 | Contradiction |
6,701 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- 40-70 years old
- having type 2 diabetes
- BMI 20-35 kg/m2
- having a sedentary lifestyle (i.e., self-reported moderate-to-vigorous physical
activity < 150 minutes per week)
- willingness to undergo randomization
-... | Light Intensity Physical Activity Trial | NCT03415880 | Contradiction |
6,995 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Aged 70 years or older.
- Family history of parent, brother, or sister who has, or had, serious age-related
memory loss, senility, dementia, or Alzheimer's disease.
- Study partner available to provide information on the cognitive status of the
... | Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) | NCT00007189 | Entailment |
680 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | No eligibility criteria
Male
No healthy subjects accepted to join the trial.
Subject must be at most 100 Years | Hemochromatosis--Genetic Prevalence and Penetrance | NCT00006312 | Entailment |
2,718 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Inguinal hernia,
- femoral hernia
Exclusion Criteria:
- pregnancy,
- not able to understand patient information
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject mus... | Mesh Fixation and Closure of Peritoneum Following Laparoscopic Hernia Repair Using N-butyl Cyanoacrylate | NCT02457728 | Entailment |
4,705 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- indication for hysterectomy for benign disease or prophylactic surgery due to
hereditary cancer
- size of uterus and vagina allows for retrieval by the vaginal route
- maximum uterine size equivalent to 16 weeks of pregnancy
- informed c... | Minimally Invasive Benign Hysterectomy | NCT01865929 | Entailment |
4,246 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- infertile men with previously abnormal semen analyses.
- Control group: fertile adult males
Exclusion Criteria:
- Proxceed use within 3 months of the start of study.
- Vitamin E supplements with > 45 IU daily
Male
Accepts Healthy Volunteers
... | Vitamin E and Male Infertility | NCT00178516 | Entailment |
2,201 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Hyperuricemic or gout patients
- Serum urate level:
>= 7.0mg/dL in patients with history of gout, or >= 8.0mg/dL in patients with hypertension,
diabetes or metabolic syndrome, or >= 9.0mg/dL
Exclusion Criteria:
- Gouty arthritis within ... | Study of FYU-981 in Hyperuricemia With or Without Gout | NCT03006445 | Contradiction |
6,475 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Participants must be over the age of 18 years old.
- Participants must have a current diagnosis of moderate-to-severe
erythematotelangiectatic or papulopustular rosacea or free of rosacea to serve as
control.
- Participants must have th... | Analysis of the Microbiome in Rosacea | NCT04108897 | Entailment |
5,913 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
Case group:
- Patients diagnosed as gastroesophageal reflux disease within 6 months had endoscopy
within 6 months and presented with reflux symptoms in the past 4 weeks.
- Patients with RDQ questionnaire score of no less than 12 points.
- Pat... | Validation of a Non-invasive In-vitro Diagnostic Test (Peptest) Against Other Diagnostic Methods for GERD | NCT02456779 | Contradiction |
5,733 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Meets the International Study Group criteria for Behcet's Disease
- Presents with at least one active lesions accessible to measurement, the largest of
which is to be designated as the index ulcer
- Index oral ulcer to be assessed should be in the e... | Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers | NCT03888846 | Contradiction |
2,556 | 19 | A 7-year-old girl is brought to the emergency department by her parents for generalized rash. The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll. Her mother suspects that something had stung her. The patient's blood pressure ... | I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. Th... | Inclusion Criteria:
- Children between 3 months and 18 years old (inclusive) admitted and hospitalized in
the pulmonary disease ward (PL and EU).
- Children between 3 months and 18 years old (inclusive) admitted and hospitalized in
the pulmonary disease ward or treated ... | Clinical Evaluation of AI-aided Auscultation With Automatic Classification of Respiratory System Sounds | NCT04208360 | Contradiction |
1,619 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- She is 18 or older
- She is currently court supervision at Bronx Community Solutions or a drug treatment
court or she is currently on probation.
- She reports using any illicit drug or drinking 4 or more alcoholic drinks in a 6-hour
per... | Women Initiating New Goals of Safety | NCT01788579 | Contradiction |
2,165 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Male or female age 20 to 80 years, inclusive
- Meets at least 6 of the 12 American College of Rheumatology preliminary criteria
(1977) for the classification of acute arthritis of primary gout, OR have proven
tophus or documented monosodium urate (... | A Proof-of-Concept Study of AC-201 to Prevent Gout Flares | NCT01712204 | Contradiction |
6,067 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patients 18 to 75 years old
- GERD documented by :
- Typical reflux symptoms (heartburn, regurgitations) completely responsive to PPI
therapy
- And/or erosive esophagitis or Barrett's esophagus at endoscopy
... | Diagnostic of Transient Lower Esophageal Sphincter Relaxation With Combined Impedance and High Resolution Manometry in Patients With GERD | NCT01844440 | Entailment |
5,134 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Low bone mineral density as determined at the time of screening [as defined by bone
mineral density (BMD) T-scores of the lumbar spine (L1-L4), or total evaluable
vertebrae (if fewer than L1-L4); or femoral neck between -1.0 and -2.5, exclusive]
- ... | An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With Low Bone Mineral Density | NCT01101048 | Contradiction |
595 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Positive urinary pregnancy test performed 18 days after oocyte retrieval in a fresh
treatment cycle or 13-16 days after embryo transfer in a frozen embryo replacement
cycle depending on the stage of embryo development at the time of transfer
Exclusion... | Pregnancies of Uncertain Location or Viability Research | NCT02700789 | Entailment |
5,144 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Body mass index (BMI) < 30
- Postmenopausal women with no evidence of osteoporosis by dual energy X-ray
absorptiometry (DEXA) scan (T ≥ -2 in the total hip and lumbar spine).
- Pre- or peri-menopausal women with osteopenia but no evidence of osteopo... | Effects of Naturally Silicon-Rich Water on Bone Metabolism in Women | NCT01067508 | Contradiction |
1,221 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Male or female, at least 18 years of age, inclusive.
2. Subject has a symptomatic MPE requiring intervention. For an effusion to be defined as
malignant, at least one of the following must be true:
1. There is histocytological confirmation of ple... | Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion | NCT04792970 | Entailment |
1,182 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Clinically confident diagnosis of malignant pleural effusion, defined as any of the
following:
1. Pleural effusion with histocytologically proven pleural malignancy OR
2. Pleural effusion in the context of histocytologically proven malignanc... | EDIT Management Feasibility Trial | NCT03319186 | Entailment |
6,435 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Signed Informed Consent that meets all criteria of current FDA regulations.
2. Healthy male or non-pregnant, non-lactating female greater than or equal to 8 years of
age with a clinical diagnosis of moderate to severe papulopustular rosacea, defined as
... | Clinical Endpoint Study of Ivermectin 1% Cream | NCT02840461 | Entailment |
2,622 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Children aged 0-18 years
- Diagnosed with inguinal hernia or communicating hydrocele
- Due to undergo laparoscopic inguinal hernia repair
Exclusion Criteria:
- Previous abdominal surgery
- Comorbidities that will effect surgical ... | Pediatric Inguinal Hernia Repair: Are Muscle Relaxants Necessary? Endotracheal Intubation vs Laryngeal Mask Airway | NCT02696837 | Contradiction |
3,888 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
Subjects eligible for enrollment in the study met all of the following criteria:
1. Subjects who are capable of giving written informed consent, which includes compliance
with the requirements and restrictions listed in the consent form.
2. Ambulatory nom ... | Efficacy Study on Symptomatic Control of Patient With Knee Osteoarthritis Between 14% of Plai (Plaivana®) to Placebo Gels | NCT01836393 | Entailment |
2,461 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
1. Patients with sarcoidosis as defined by the ATS/ERS/WASOG statement on sarcoidosis as
defined by the clinical presentation consistent with sarcoidosis, biopsy finding
granulomas, and no alternative for the cause of the granulomas, such as tuberculosis
... | Trial of Antimycobacterial Therapy in Sarcoidosis | NCT01074554 | Entailment |
4,347 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Healthy young adult males with myopia <-8D
Exclusion Criteria:
- Best corrected visual acuity <6/9
- Previous intraocular surgery
- Intraocular pressure >21mmHg
- Gonioscopic findings of angle closure
- Clinical evide... | Optical Coherence Tomography Imaging of the Posterior Segment in High Myopia. | NCT00347451 | Entailment |
2,689 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- inguinal hernia
Exclusion Criteria:
- recurrent hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Comparison Open Lichtenstein Repair and Totally Extraperitoneal Herniorrhaphy | NCT03820570 | Entailment |
6,389 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Diagnosis of COVID-19 confirmed on RT-PCR test or chest scanner
- Any age
- Membership in the general social security system
- Inform consent signed by the patient or by legal representatives for minors
Exclusion Criteria:
- Refu... | Collection of Biological Samples With Clinical Characterization of Covid-19 Patients | NCT04363385 | Entailment |
2,176 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- 1. The subject has given his / her informed consent to participate in this study; the
Informed Consent Form has been signed both by the patient and the Investigator;
- 2. Established diagnosis of gout according to Gout Classification Criteria established
... | Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Evaluation of RPH-104 Administered at Different Doses to Patients With Acute Gout Attack | NCT04067492 | Contradiction |
2,533 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Caucasian, Hispanic and African American children ages 6 months to 5 years with a
diagnosis of atopic dermatitis within the last 12 months will constitute the candidate
pool for enrollment into the study group. The diagnosis of atopic dermatitis will be
... | Histamine Pharmacogenetics in Children With Atopic Dermatitis | NCT00277433 | Entailment |
5,978 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Adults ages 21-70 years old
- Heartburn symptoms 3 or more days per week with an average daily symptom severity of 3
or more on a 7 day baseline symptom diary
- English language proficiency
- Willingness to be videotaped and connected to... | Correlates of GERD Symptom Severity | NCT03020550 | Entailment |
4,626 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Adult male and female in-patients with vital signs considered 'stable' by clinical
caregivers.
Exclusion Criteria:
- Pediatric patients
- Female patients who are pregnant
- Patients with internal or external defibrillators
... | Vital Signs Patch Early Feasibility and Usability Study v1.0 | NCT02524470 | Entailment |
1,288 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Patient is > 18 years of age at the time the Informed Consent is signed.
- Patient has a pathologically confirmed diagnosis of either Malignant
Pleural/Peritoneal Mesothelioma (MPM), Serous Ovarian Adenocarcinoma,
Cholangiocarcinoma, or Non-Small C... | Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer | NCT03907852 | Entailment |
6,753 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- May be either male or female
- Age: 18 years or older
- Subjects with a single-rooted tooth (except mandibular incisors) indicated for
extraction
- Extractions socket walls should either be intact or have no more than one bony wall
... | Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen® | NCT03659617 | Entailment |
6,615 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients diagnosed with AHA based on a reduced FVIII activity (<50 %) and positive
FVIII inhibitor (>0.6 BU/ml) at screening (local laboratory)
- Signed informed consent form by the participant or a Person who is legally authorized
to sign on behal... | Emicizumab in Acquired Hemophilia A | NCT04188639 | Contradiction |
4,591 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women with menstrual pain of more than 6 months of evolution.
- Women with pain equal to or greater than 4 on the visual analogue scale in more than
half of their one-year menstrual cycles.
Exclusion Criteria:
- Hormone treatment
... | Effectiveness of Manual Therapy in Dysmenorrhea | NCT03593057 | Contradiction |
6,579 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Age 16 or over.
- Have documentation of physician-confirmed diagnosis of moderate or severe Hemophilia A
(severity defined as moderate = FVIII activity 1% to 5% and severe = FVIII activity
≤1%).
- Signed written informed consent provide... | Patient Functioning and Well-being, Economic, and Clinical Impact of Hemophilia A and Its Treatment | NCT02396862 | Contradiction |
3,408 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | INCLUSION CRITERIA
ETD participants:
- Bilaterally intact tympanic membranes
- aged 5 to 60; generally good health
- ability to understand and give informed consent
- history of myringotomy tubes, recurrent middle ear infections, recurrent middle ear
... | Tubomanometry and EarPopper Devices for Eustachian Tube Function Testing | NCT03850197 | Contradiction |
4,746 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Clinical diagnosis of peripheral vestibular dysfunction and no other neurological
deficit (confirmed where possible with vestibular function testing; canal paresis
>20%).
- One of the following subjective complaints indicating a failure of vestibul... | Conventional Versus Virtual Reality Based Vestibular Rehabilitation | NCT01442623 | Contradiction |
5,213 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Are postmenopausal women at least 55 years old and at least 2 years postmenopausal at
the time of entry into the trial, and who have given informed consent before entering
the study and after being informed of the risks, medications, and procedures to be
... | Study of Teriparatide in the Treatment of Postmenopausal Women With Osteoporosis | NCT00532207 | Entailment |
3,650 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Patients with active nose bleeding
- Indication for routine blood sampling
- Aged 18 to 99 years
- Verbal informed consent before implementation takes place
- Written consent of the participating person after investigation and completion ... | Hemoglobin and INR Out of Nose Blood | NCT02370381 | Entailment |
5,895 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Key Inclusion Criteria:
1. Male or female patients > 18 years of age.
2. If female, not of childbearing potential by reason of surgery or menopause, or of
childbearing potential, but using an approved method of contraception since the last
menstrual period. Females of chi... | E3810-A001-312: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers | NCT00236197 | Contradiction |
786 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Osteo-arthritis of knee joint diagnosed through X-Ray evaluation
2. Moderate or sever level of pain due to knee osteoarthritis and no other known reason
3. Male of Female patients of 18 to 85 years old
4. Pain interfering with activities of daily life
... | The Effect of Low Intensity Ultrasound Therapy on Chronic Pain Due to Osteoarthritis of the Knee. | NCT03679507 | Entailment |
6,921 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
1. Signed and dated written informed consent obtained from the subject or the subject's
legally acceptable representative ( if applicable) in accordance with the local
regularities.
2. Both male and female, aged > 50 and <90, if women, must have no chi... | Biomarker Study to Diagnose Alzheimer's Disease | NCT01874418 | Entailment |
1,490 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- to present with GI symptoms that are secondary to EMD such as dysphagia, regurgitation
and/or non-cardiac chest pain.
- the EMD patients to be recruited under this study are achalasia type I, II and III;
OGJ outflow obstruction; distal oesophageal ... | Pressure and Flow Study Before and After Treatments for EMD. The pFlow Study | NCT03904004 | Entailment |
3,968 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Voluntary signature of the IRB approved Informed Consent
2. Unilateral osteoarthritic male or female ages 35-85
3. Pain, swelling, and/or functional disability in the affected knee consistent with
osteoarthritis in one knee joint
4. Physica... | A Controlled Surveillance of the Osteoarthritic Knee Microenvironment With Regenexx® SD Treatment | NCT02370823 | Entailment |
5,375 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Age 18-35
- Normal menstrual periods (24-35 days)
- Good general health
- Willing to use a non-hormonal form of contraception for the entire study (Acceptable
forms of contraception include condoms, spermicide, sexual contact with a ster... | The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle | NCT00614406 | Entailment |
1,369 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Children below 5 years of age
- Functional constipation according to Rome III criteria i.e. 1 month of at least 2 of
the following:
- Two or fewer defecations per week
- At least 1 episode per week of incontinence after the acq... | Lcr35 for Children With Functional Constipation | NCT01985867 | Contradiction |
2,422 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Ability to provide written informed consent (parental/guardian consent if
applicable)/assent (if <18 years of age).
- Male sex.
- Age ≥5 years.
- Phenotypic evidence of DMD/BMD based on the onset of characteristic clinical symptoms
... | Phase 2B Study of PTC124 (Ataluren) in Duchenne/Becker Muscular Dystrophy (DMD/BMD) | NCT00592553 | Entailment |
1,808 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Healthy volunteers
Inclusion criteria:
- No gastrointestinal symptoms or history of gastrointestinal disease meeting ROME III
criteria for functional dyspepsia and Irritable Bowel Syndrome (IBS).
Exclusion criteria:
- Inability to stop the intake of nonsteroidal antiinflam... | Functional Dyspepsia and Symptom Perception | NCT02522000 | Contradiction |
1,023 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- hand arthritis
- pain over 40/100
- stable treatment since 4 weeks at least with non-steroid analgesic
- between 45 et 85 years
Exclusion Criteria:
- pregnancy or breast feeding women
- hyaluronic acid injection withi... | Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo | NCT01068405 | Entailment |
3,535 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Adults, male or female aged 19 years or older
- newly diagnosed with adrenal disease such as adrenal incidentaloma, pheochromocytoma,
primary aldosteronism, adrenal cushing syndrome, adrenocortical carcinoma
Exclusion Criteria:
- previous o... | A Prospective Cohort Study for Patients With Adrenal Diseases | NCT03474237 | Entailment |
388 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Both ovaries are present
- Day 2 FSH <10 mIU/L
- Day 2 Estradiol <50 pg/L
Exclusion Criteria:
- Polycystic ovarian syndrome (PCOS)
- Abnormalities affecting the uterine cavity
- Uncontrolled diabetes
- All... | Evaluation of the Role of Follicular Sensitivity Index in the Prediction of Pregnancy in Women Undergoing ICSI/IVF Without Polycystic Ovarian Syndrome | NCT02158026 | Contradiction |
6,440 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Healthy patients 18-55 years of age with erythematotelangiectatic rosacea (as verified
by the the PI).
- Subjects who are willing to provide informed consent for participation in the study.
Exclusion Criteria:
- Pregnant or lactating indivi... | Pulsed Dye Laser (PDL) vs. Microsecond 1064-nm Nd:YAG Laser for Treatment of Diffuse Facial Redness | NCT01529996 | Entailment |
3,609 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- ≥18 years of age
- cognitively intact
- consent to participation.
Exclusion Criteria:
- patients arriving to the ED regarding injury
- patient with the highest triage level
- demented patients
- intoxicate... | Degree-of-worry and Illness Perception in Patients Suffering From Acute Illness in the Emergency Department | NCT04226040 | Entailment |
5,482 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
Any patient admitted to our Emergency Department who is
- age > 16 years
- pain lasting =< 1 week or
- no pain on admission but pain during the ED stay
Exclusion Criteria:
- life-threatening condition requiring immediate admission in ... | Management of Acute Pain in the Emergency Department | NCT00470652 | Contradiction |
1,501 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria
1. 65 years of age or older
2. Dysphagia diagnosis based on videofluoroscopic swallow study with observed airway
invasion (Penetration-Aspiration Scale score of 3 or higher)
3. Ability to provide consent
4. Ability to submit oral samples
... | Impact of Probiotics on Oral Microbiota in Older Adults With Dysphagia | NCT03682094 | Entailment |
6,545 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- age ≥ 12 years and ≤ 55 years
- severe haemophilia A (FVIII < 1%)
- absence of inhibitors (Bethesda titre < 0.6 BU/ml)
- Previous Treated Patients (prior exposure days > 200)
- Kogenate Bayer administered 20-30 IU/kg -3 times a week, for ... | Prophylaxis Versus On-demand Therapy Through Economic Report | NCT01159587 | Contradiction |
4,459 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Age 18-65
- Pain at the lateral side of the elbow ≥8 weeks
- Local tenderness on palpation of the lateral epicondyle
- Pain on resisted extension of the wrist
Exclusion Criteria:
- Rheumatic disorder
- History of fibr... | Doxycycline for Lateral Epicondylalgia - RCT | NCT00631501 | Contradiction |
2,836 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria
- Diagnosis of probable or definite ALS
- At least 5 of 10 testable upper extremity muscle groups (shoulder and elbow
extensors/flexors and grip) of Medical Research Council (MRC) grade 4 or better
- At least 5 years from onset of symptoms
Exc... | Creatine for the Treatment of Amyotrophic Lateral Sclerosis | NCT00070993 | Entailment |
4,652 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Patients suffering from dysmenorrhea for at least the previous 3 months prior to Visit
1 with a minimum visual analogue scale (VAS) score of 30 mm with regard to pain during
the menstrual period of the screening period
- Good general health (except... | To Investigate Efficacy of YAZ in the Treatment of Dysmenorrhea | NCT02617537 | Entailment |
1,988 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients diagnosed with adenocarcinoma in the gastroesophageal junction
- Patients assumed to be resectable
Exclusion Criteria:
- lack of consent
- non-adenocarcinomas
No condition on gender to be admitted to the trial.
No healthy subjects a... | Gastric Microperfusion in Patients Undergoing Gastroesophageal Resections | NCT02077673 | Entailment |
3,444 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Diagnosis of type 2 diabetes for at least 6 months
- Diabetes for a maximum of ten years
- Updated HbA1c level of between 8.5 and 11% from the last month
- Agreement to participate and sign an informed consent
Exclusion Criteria:
... | Financial Incentives for Low Socioeconomic Diabetic Patients | NCT03506230 | Entailment |
814 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- 1- Mild knee pain during walking on flat surface diagnosis via KOOS questionnaire (3
out of 10) because our aim of the study to reduce pain with combined treatment and
pain lower than 3 out of 10 score might not allow to compared the pain reduction
... | Effect of a Lateral Wedge Insole and Simple Knee Sleeve in Individuals With Knee Osteoarthritis | NCT03225911 | Entailment |
6,880 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion criteria:
1. Patients diagnosed of diabetes mellitus type 2 with time evolution ⋝5 years.
2. Age between 65 and 85 years old (both included).
3. Ability to read and write.
4. Active treatment with hypoglycemic agents.
5. Diagnosed with mild cognitive impa... | Diabetes as an Accelerator of Cognitive Impairment and Alzheimer's Disease | NCT03578991 | Contradiction |
506 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age ≤ 40.
- AMH ≥ 0.3 ng/ml and ≤ 1.2 ng/ml.
- OR 3 ≤ AFC ≤7.
- Normal shape of uterus (based on ultrasound).
- Body mass index within 28 - 37 kg/m2
Exclusion Criteria:
- Asherman's syndrome.
- Endometrios... | Double Stimulation in Women With Low Prognosis in ART | NCT04531644 | Contradiction |
3,566 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | Inclusion Criteria:
1. Signed informed consent, demonstrating that the patient understands the procedures
required for the study and the purpose of the study
2. Male or female patients of any age (interest is given to children to compare with
mothers)
3. Diagno... | A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease | NCT04148222 | Entailment |
6,156 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- pcr positive for covid -19 who are survived
Exclusion Criteria:
- dead patient uncooperative
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Post Covid-19 Cardiopulmonary and Immunological Changes | NCT04388436 | Contradiction |
3,112 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria
Patients will be eligible for inclusion if all these criteria are respected:
1. Age of at least 18 years
2. Provides written informed consent prior to study-related procedures at the screening
visit
3. Is able to understand and willing to comply ... | Effect of Single Instillation of Three Different Topical Lubricants on Tear Film Thickness in Patients With Dry Eye Syndrome | NCT03161080 | Contradiction |
4,597 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Mobile uterus.
- Uterine size up to 12 weeks gestation.
- Benign lesions.
Exclusion Criteria:
- Enlarged uterus > 12 weeks gestation.
- Suspected malignancy.
- Large adnexal masses.
Female
Accepts Healthy Volunteers
S... | Total Laparoscopic Hysterectomy vs Minilap Hysterectomy | NCT03251677 | Contradiction |
6,095 | 45 | A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is o... | My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor dia... | Inclusion Criteria:
- Parents with babies with Down Syndrome between 4 and 8 months old.
Exclusion Criteria:
- Parents with babies without Down Syndrome.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
| Effects of Infant Massage on Acceptance, Commitment and Conscience of Influence of Parents With Down Syndrome Babies | NCT03126734 | Entailment |
4,075 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- idiopathic RBD (criteria of the international classification of sleep disorders-3)
For healthy controls : no neurologic or psychiatric disorder
Exclusion Criteria:
- Contraindication to MRI
- Do not speak French
No condition on gender to be admitt... | Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE) | NCT03072940 | Contradiction |
4,992 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Consenting male and female participants, aged 18 years to 80 years
- PD individuals diagnosed by UK Brain Bank Criteria with stage H&Y2-3 disease or ET
with hand tremor in their motor dominant hand
- Stable IPD/ET medication management for the 6 mon... | Kinematic-guided BoNT-A Treatment for ET and PD Tremor | NCT02427646 | Entailment |
768 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- sub-healthy persons >18 years of age and knee joint pain with a 0-10 numerical rating
scale (NRS) pain score ≤ 4.
Exclusion Criteria:
- current medication use related to arthritis;
- current use of FAC containing products;
- cli... | Effect of Cis-9-cetylmyristoleate in Sub-healthy Subjects Presenting With Knee Joint Pain | NCT02800759 | Contradiction |
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