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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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6,954 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
1. AD group :
- Male or female patient, aged ≥ 40 years old included at entry.
- Patients having a clinical diagnosis of probable AD according to DSM-IV TR
[F00.xx] and National Institute of Neurological and Communicative Disorders and
... | Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia | NCT00880347 | Entailment |
4,105 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- Specific inclusion criteria for RBD patients - to reach the diagnosis criteria of RBD
(International Classification of Sleep Disorders 2)
- Specific inclusion criteria for PD patients - to reach the diagnosis criteria of
idiopathic PD (Queen Square... | Gait and REM Sleep Behavior Disorder | NCT02554331 | Entailment |
4,549 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Females and males between 18 to 55 years of age, inclusive
2. BMI between 18.5 to 32 kg/m2, inclusive
3. Self-reported history of diarrhea over the last 3 months, defined as > 5 BMs with the
majority (≥ 50%) of the BMs per week being Bristol stool for... | A Study to Investigate the Safety and Efficacy of a Probiotic on Gastrointestinal Health in Healthy Adults | NCT04223388 | Contradiction |
6,150 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- SARS-Co-V2 positivitity to the nasal-swab by reverse-transcriptase-polymerase chain-
reaction (RT-PCR) assay tested by the local diagnostic laboratory
- Age >18 and <85 years
- Presence of at least 3 of the following symptoms as present fever, cough... | Baricitinib Therapy in COVID-19 | NCT04358614 | Contradiction |
1,412 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Subjects should be over 60 years of age with essential isolated systolic hypertension
(stage I-II base on recommendation of JNC-VII) for the hypertension group and normal
blood pressure in the healthy group. Good communication, independent physical
... | Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension | NCT02270216 | Contradiction |
5,081 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
Known AFF group
1. A subject must have experienced an incomplete atypical low trauma fracture of the
femoral shaft;
2. Is a patient at the UHN osteoporosis clinic.
Comparison Group
1. Must be scheduled for a bone mineral density scan at... | Evaluation of IVA (SE Femur Scans) to Identify Incomplete AFFs | NCT01747304 | Contradiction |
2,938 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Male or female subjects between 18-80 years of age, inclusive
2. Subjects with a diagnosis of probable or definite ALS in accordance with the Revised
El-Escorial Criteria
3. Subjects must be currently on an oral diet and able to take foods and liquids... | Riluzole Oral Soluble Film (ROSF) Swallowing Safety in Amyotrophic Lateral Sclerosis (ALS) | NCT03679975 | Entailment |
29 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Women age 18-55
- Hypopituitarism with documented central adrenal and gonadal deficiencies. Serum
testosterone level of < 20 ng/dl or free testosterone <1.5 pg/ml on conjugated equine
estrogen replacement
- No other significant medical ... | Baseline Sexual Function, Cognitive Function, Body Composition and Muscle Parameters and Pharmacokinetics of Transdermal Testosterone Gel in Women With Hypopituitarism | NCT00144404 | Contradiction |
2,868 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Patients classified as having clinically definite, clinically probable, clinically
probable (laboratory-supported) or clinically possible ALS according to the
El-Escorial diagnostic criteria for ALS (see Appendix 2).
2. Able to comprehend and willin... | A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS) | NCT03272503 | Entailment |
4,737 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Age between 40 and 70 years.
2. Uterine weight more than 280gm. the weight will be estimated sonographically using
algebraic formula by Kung and Chang expressed in weights and measurements: weight(g)=
50+(4/3 x π(Pi) x L/2 x W/2 x AP/2) where (L) is... | Vaginal Hysterectomy Versus Laparoscopically Assisted Vaginal Hysterectomy for Large Uteri | NCT02826304 | Entailment |
2,421 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Diagnosis of DMD based on a clinical phenotype presenting by age 5, with increased
serum CK and decrease of dystrophin on a muscle biopsy
- Presence of a nonsense mutation in the dystrophin gene
- Physical examination or radiographic imaging documen... | Safety and Efficacy Study of PTC124 in Duchenne Muscular Dystrophy | NCT00264888 | Entailment |
2,261 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Written informed consent from parent or legal guardian prior to participation and, for
patients who are 7 years of age, written assent from patient
- Diagnosis of DMD based on a clinical phenotype with increased serum CK and the
presence of a mutat... | Phase 1/2 Study in Boys With Duchenne Muscular Dystrophy | NCT02439216 | Contradiction |
5,235 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Ambulatory, postmenopausal women aged 55-85 years (at least 3 years have elapsed after
menopausal) are included at the time of entry into the trial. They have to be free of
severe or chronically disabling conditions other than osteoporosis.
- The p... | PTH Comparison in Post Menopausal Women | NCT00543218 | Entailment |
6,465 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Male or female
2. 18 years of age or older
3. Clinical diagnosis of rosacea
4. Moderate to severe persistent facial erythema associated with rosacea at baseline, as
determined by: a grade of greater than or equal to 3 on the 5 point grading... | Mirvaso® Gel and Dysport® for Erythema and Flushing of Rosacea | NCT03508869 | Entailment |
5,705 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Turner Syndrome Females:
Inclusion Criteria:
- Turner Syndrome confirmed by chromosomal testing
- On standard therapy (growth hormone and or estrogen)
Exclusion Criteria:
- Type 1 or Type 2 diabetes
- Polycystic Ovarian Syndrome
- Pregnancy
... | Risk of Diabetes in Young Turner Syndrome Patients | NCT02160717 | Entailment |
6,449 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Healthy male or non-pregnant female aged ≥ 18 years with a clinical diagnosis of
facial papulopustular rosacea.
2. Subjects must have provided IRB approved written informed consent.
3. Subjects must have at least 15 and not more than 50 inflammatory f... | Bioequivalence Study of Ivermectin Cream 1% in Treatment of Moderate to Severe Facial Rosacea | NCT04106726 | Entailment |
5,486 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Age of 50 years or older
- Social insurance
- Diagnosis of AION, characterized by sudden and painless loss of vision, of less than
one week, accompanied by pallid swelling of the optic disc
- Diagnosis of GCA based on ACR 1990 criteria, ... | Efficacy of Tocilizumab for the Treatment of Acute AION Related to GCA | NCT04239196 | Contradiction |
917 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Male or female at least 18 years of age at time of screening.
2. Ability to comply with study procedures and visit schedules and able to follow oral
and written instructions.
3. Patients with symptomatic OA in one knee from 3 months
4. A st... | Intra-articular Oxygen-ozone Therapy for the Treatment of Knee Osteoarthritis Compared With Hyaluronic Acid | NCT04426721 | Entailment |
649 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- patients who are eligible for a primary Roux- en -Y gastric bypass and who have no
pre-existing iron deficiency (serum ferritin between 20-200 micrograms/L)
Exclusion Criteria:
- blood transfusion one month before ans in the study period. The use of ir... | Iron Absorption Trial | NCT02228902 | Contradiction |
3,855 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Knee osteoarthritis
Exclusion Criteria:
- WOMAC less than 4
- Use of braces
- Uncontrolled hypertension
- Significant psychiatric or psychotic disorder
- Not able to attend 75% of sessions
- Any other reas... | An Innovative Mind-motor Exercise Approach to Osteoarthritis Treatment | NCT02753634 | Entailment |
1,058 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- At least one documented spontaneous VVS during preceding 12 months or one syncope in
history leading to injury and minimum 2 presyncopal events during preceding 12 months,
refractory to all recommended types of standard treatment.
- In case of lack... | Cardioneuroablation for Reflex Syncope | NCT03903744 | Contradiction |
6,143 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Group A: Mild to moderate COVID-19 (non-pregnant)
• Current male or female COVID-19 infected (age 18-60 years old) with mild to moderate
illness
2. Group B: Severe to critical COVID-19 (non-pregnant)
• Current male or female COVID-19 ... | Evaluation of Humoral Immunity Following COVID-19 in Pregnancy | NCT04568044 | Contradiction |
6,460 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Subject is male or female aged 18 to 80 years inclusive.
- Subject with papulopustular rosacea (11 to 40 papules or pustules) and an IGA of
moderate or severe.
- For subjects using medications to treat a concurrent medical condition, type and dose
... | Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo | NCT01426269 | Entailment |
6,932 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Clinical diagnosis of Alzheimer's Disease
- Patients with increased risk for developing dementia
- Must be able to give their consent
Exclusion Criteria:
- Contra-indications for MRI scanning
- Substance abuse
- Sever... | Tablet-based Cognitive Training | NCT04452864 | Entailment |
3,098 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- mild/moderate intellectual disability
- students at the upper secondary schools for intellectual disability students
Exclusion Criteria:
- severe intellectual disability
- obesity related syndromes
- major physical disabilities
N... | School Intervention With Daily Physical Activity and Healthy Food for Students With an Intellectual Disability. | NCT01291238 | Entailment |
5,768 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Adults with definite or probable dermatomyositis or polymyositis and pediatric
patients five years of age and over with definite or probable juvenile dermatomyositis
(JDM) by Bohan and Peter criteria. Diagnosis of JDM based on an age of onset (i.e.,
... | Rituximab for the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Adult Polymyositis (PM) | NCT00106184 | Contradiction |
2,355 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Boys age ≥7 years with DMD confirmed clinically and by mutation analysis able to
undergo cardiac magnetic resonance (CMR) without sedation
- LV EF ≥45% (+/-5%) by clinically-acquired echocardiography, nuclear scan or cardiac
MRI done within 2 weeks... | Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular Dystrophy | NCT02354352 | Entailment |
6,197 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patient hospitalized for CoViD-19 infection during the health crisis, in a short-stay
service of Reims University Hospital and included in Covid-19 Cohort
- Age > 18 years
- Patient who benefit from the national health insurance coverage
... | CoViD-19 Patient in Reims University Hospital in March to April 2020 | NCT04553575 | Contradiction |
4,080 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
---
Exclusion Criteria:
Participants with a history of neurological disorders or of sleep disorders will be
excluded.
Participants who do not believe they would be able to fall asleep in the lab will be
excluded.
No condition on gender to be admitt... | The Effects of Direct Context Reactivation During Sleep on Memory | NCT04702152 | Contradiction |
3,424 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Male or female subjects, age 20 to 75 years, inclusive with type 2 diabetes mellitus.
- At Visit 2/Period 1/Day 1, subjects will have been treated for their diabetes by
metformin (≥1000 mg/day; any type and regimen), metformin and a DPP-4 inhibitor (
... | A Study of Single and Multiple Doses of Oral Insulin or Placebo in Subjects With Type 2 Diabetes Mellitus | NCT02954601 | Entailment |
5,925 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Eligible participants included patients ≥20 years with either overweight (BMI of 25-30
kg/m2) or obese (BMI > 30 kg/m2), who had undergone panendoscopy due to typical
clinical symptoms of either acid regurgitation, heartburn sensation, or both. By the
... | Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis | NCT02759393 | Contradiction |
6,293 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Confirmed diagnosis of SARS-CoV-2 disease, detected by PCR or antigen test, performed
72 h prior to patient inclusion in the study.
- Acceptance to sign the informed consent document.
- Possession of a Smartphone or Tablet with Internet connection.
... | Clinical Decision Support System Based on Non-invasive Tele-monitoring of COVID-19 Patients | NCT04802018 | Entailment |
4,859 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | PROTOCOL ENTRY CRITERIA:
- Adults and teenagers with untreated, spontaneous active Cushing's syndrome
- Diagnosis verified at the University of Michigan Medical Center, including the
following: Excessive cortisol secretion measured by urinary-free cortisol, cortisol
sec... | Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome | NCT00004326 | Entailment |
1,135 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | - INCLUSION CRITERIA:
The following is a representative list of the types of patient presentations and potential
diagnoses eligible for this protocol:
1. Coronary artery disease with angina or inducible myocardial ischemia as determined by
noninvasive testing.
2. Car... | Evaluation of Patients With Known or Suspected Heart Disease | NCT00001313 | Entailment |
4,967 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
1. Male or female patients aged ≥ 25 and ≤ 80 years
2. Patients with Essential Tremor according to the criteria of the consensus statement of
the movement disorders society (Deuschl et al. 1998) are included with a medical
treatment resistant and disab... | Deep braIn Stimulation for Tremor TractographIC Versus Traditional | NCT02491554 | Entailment |
1,565 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- A cancer survivor of breast, prostate, lung, colorectal, cervical or oral cancer
survivor and live within the Baltimore Maryland area.
- Finished your active cancer treatment at least three months ago.
- Overweight or obese and do not exercise daily... | Physical Activities by Technology Help (PATH) | NCT03212079 | Contradiction |
5,057 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- The study will enroll 40 postmenopausal women with a T score < -2 either at the lumbar
spine or the femoral neck: 20 who decide to begin anti-resorptive therapy (treated
group), and 20 women who decline such therapy (control group). We will attempt to
... | Texture Analysis for Postmenopausal Osteoporosis | NCT00145977 | Contradiction |
4,430 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Patients aged >18 years
- A symptom duration of >3 months
Exclusion Criteria:
- Bilateral symptoms
- Rheumatologic diseases affecting the elbow and the wrist
- Musculoskeletal disorders due to connective tissue diseases
... | Investigating the Effects of Neuromobilization in Lateral Epicondylitis | NCT04219488 | Contradiction |
1,881 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Histological diagnosis of adenocarcinoma of the stomach, gastro-esophageal junction
(GEJ), or lower third of the esophagus.
- The tumor must be deemed by the team to be potentially resectable. This includes
imaging studies (detailed below) to clini... | Pilot Study of Perioperative Docetaxel, Oxaliplatin, and 5-Fluorouracil (FLOT) in Gastroesophageal Adenocarcinoma | NCT01932580 | Entailment |
705 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- over 50 years of age
- Osteoarthritis > Grade 3 on the Kellgren-Lawrence scale
- Presence of at least two of the following findings:
- morning stiffness that resolves within 60 minutes
- pain > 3/10 on a numerical pain rating scale
... | Effectiveness of Manual Therapy and Exercise in Shoulder OA | NCT02587559 | Contradiction |
803 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Males or females at the age of 40-75 years old
2. Conforming to the diagnosis standard of the American College of Rheumatology in 2009：
knee pain and osteophyte determined with X-ray, and at least one of the following
items：
- above... | Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) | NCT02323451 | Entailment |
653 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- - Patients treated with iron chelators;
- Patients treated with erythroid growth factors (erythropoietin);
- Patient with excessive alcohol consumption (> 20g/day and > 30 g/day for women and men
respectively);
- Patients with chronic ha... | Impact of Transferrin Saturation Guided Maintenance Treatment on Quality of Life in HFE Haemochromatosis | NCT04779593 | Contradiction |
2,763 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Unilateral inguinal hernia (diagnosed by physical examination or imaging)
- Sexual Active
- Male gender
- aged between 18 and 65
- ASA 1-2
- EHS Classification (Primary, lateral or medial, 1 and 2)
Exclusion Criteria:... | COMPARISON OF LAPAROSCOPIC TOTAL EXTRAPERITONEAL HERNIA REPAIR AND LICHTENSTEIN HERNIA REPAIR | NCT03935503 | Entailment |
3,302 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- Patient should suffer from Optic Nerve Atrophy diseases like diabetic retinopathy and
retinal pigmentation.
- Age in between 18-55 years old
- Willingness to undergo bone marrow derived autologous cell therapy.
- Ability to comprehend th... | Treatment of Optic Neuropathies Using Autologous Bone Marrow-Derived Stem Cells | NCT02638714 | Contradiction |
4,785 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
1. Ability to provide informed consent.
2. Eighteen years-of-age or older at the time of implantation.
3. Presence of single-sided deafness as follows:
1. Poorer ear (ear to be implanted):
- severe to profound sensorineural heari... | Implantation of the Cochlear® Nucleus® System in Adults With Single-Sided Deafness | NCT01670006 | Entailment |
2,529 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Chronic urticaria
- Eczema & dermatitis group
- Atopic dermatitis
- Prurigo group: Acute prurigo, Prurigo subacuta, Chronic prurigo
- Pruritus cutaneous: Systemic pruritus cutaneous, Topical pruritus cutaneous
- Giving informe... | Study Of Cutaneous Disease Accompanied With Pruritus In Pediatrics | NCT00257582 | Entailment |
5,063 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- - Two osteoporotic vertebra compression fractures in the low thoracic or lumbar spine
- men and women > 18 years old
- patients with healthcare insurance
- signed and dated informed consent
Exclusion Criteria:
- men and women < 1... | Efficacy of Fluoroscopy-guided Epidural Anesthesia for Osteoporotic Vertebral Compression Fracture Treated by Percutaneous Vertebroplasty | NCT03621527 | Contradiction |
2,537 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
1. Patients aged 2 years or older at the time of consent.
2. Patients may be male or female.
3. Patients may have any skin phototype.
4. Patients with a clinical diagnosis of atopic dermatitis according to the Hanifin and
Rajka criteria. Atopi... | Characterizing Skin Microbiome Change in Atopic Dermatitis | NCT04800185 | Entailment |
3,839 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Male or female ≥40 years and ≤75 years.
- Willingness and ability to comply with the study procedures and visit schedules and
ability to follow verbal and written instructions.
- Diagnosis of knee osteoarthritis (OA) Grade 2 or 3 according to the Ke... | APSS-33-00: A Multicenter, Pilot Study of Autologous Protein Solution (APS) in Knee Osteoarthritis (OA) | NCT02138890 | Entailment |
533 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- healthy pregnant women candidate for surgical evacuation
- 1st trimesteric pregnancy loss with gestational age 12 weeks or less (diagnosis was
confirmed using transvaginal ultrasound according to the following criteria:
Crown-rump length {CRL} of 7... | Misoprostol Versus Effox as Cervical Ripening Agent Prior Surgical Evacuation | NCT02738177 | Contradiction |
3,219 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Is at least 17 years of age and has full legal capacity to volunteer;
- Has read and signed an information consent letter;
- Is willing and able to follow instructions and maintain the appointment schedule;
- Is diagnosed with Sjogren's Syndrome;
... | Effect of Debridement-scaling on the Relief of Dry Eye Signs and Symptoms in Sjogren's Syndrome | NCT02203188 | Entailment |
5,755 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
1. Patients free from any systemic disease according to the detailed questionnaire of the
modified Cornell Medical Index 34.
2. Patients not receiving any medication either topical or systemic that could cause
lichenoid reaction during the 3 months bef... | Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial | NCT04091698 | Contradiction |
6,027 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Adults with complaints of GERD, reflux, and/or heartburn symptoms
Exclusion Criteria:
- None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients | NCT04120025 | Entailment |
3,023 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Partners-affiliated pediatric practice providers utilizing Longitudinal Medical Record
(LMR), which is an electronic health record system. Also the parents of the patients
of the above noted pediatric providers.
Exclusion Criteria:
- Non-P... | Improving Pediatric Safety and Quality With Health Care Information Technology | NCT00134823 | Entailment |
978 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patients with symptomatic knee OA (patellofemoral)
- Exclusion Criteria:
- Not using the brace as requested;
- Study abandonment;
- No adaptation to brace;
- Skin and vascular complications by use of the brace;
- F... | Bracing for Patellofemoral Osteoarthritis | NCT02984254 | Entailment |
6,131 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | INCLUSION CRITERIA:
1. Provide written informed consent before initiation of any study procedures.
2. Age greater than or equal to 18 years old and less than or equal to 70 years old.
3. Subjects must not be symptomatic, must be afebrile for ≥14 days, beyond 28 days of the
... | Collection of Anti-SARS-CoV-2 Immune Plasma | NCT04344977 | Contradiction |
3,484 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. A known history of Type 2 Diabetes receiving either diet alone or oral antidiabetic
drugs (OAD) including insulin secretagogues, pioglitazone, DPP4 inhibitors, or
metformin as monotherapy or in combination therapy, or low-dose insulin at <0.5
unit... | Exenatide Inpatient Trial: A Randomized Controlled Pilot Trial on the Safety and Efficacy of Exenatide (Byetta®) Therapy for the Inpatient Management of Patients With Type 2 Diabetes | NCT02455076 | Entailment |
6,359 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients must be 18 years of age or older, of either gender
- Patients must be tested positive for SARS-CoV-2 by RT-PCR
- Patients must exhibit typical symptoms of COVID-19 disease at screening such as fever,
fatigue, a dry and contagious cough, los... | Study to Investigate the Clinical Benefits of Dietary Supplement Quercetin for Managing Early COVID-19 Symptoms at Home | NCT04861298 | Entailment |
4,252 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- >18 years
- Participation in more than 80% during training and matches of the competitive season.
- First, intermediate, Pre-intermediate A and Pre-intermediate B categories of the
University teams of Córdoba, Old Resian and Los Matreros, belonging ... | Impact and Burden of Rugby Injuries in Argentina. A Complete Season Retrospective Multicentric Study. | NCT04402567 | Entailment |
4,095 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
Study participants:
- Subjective complaints of Excessive daytime sleepiness (EDS) and/or Hypersomnia (H) as
defined above
- EDS and/or H present daily or almost daily for at least 1 month prior to the
consultation
- Ability and c... | Swiss Primary Hypersomnolence and Narcolepsy Cohort Study | NCT04330963 | Entailment |
3,606 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
Each woman enrolled in the trial must meet the following inclusion criteria:
- Competent to provide informed consent to participate in the trial and has done so.
- At least the minimum age is 18 to 45 years old.
- Had sex 1 to 4 days in past month and exp... | Pericoital Oral Contraception With Levonorgestrel | NCT00922233 | Entailment |
6,747 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Males age 18 years or older.
- Confirmed diagnosis of hemophilia A as evidenced by their medical history with plasma
FVIII activity levels < 1% of normal or at screening.
- Have >150 exposure days (EDs) to FVIII concentrates (recombinant or plasma-d... | Study to Test the Safety and How Well Patients With Severe Hemophilia A Respond to Treatment With BAY 2599023 (DTX 201), a Drug Therapy That Delivers a Healthy Version of the Defective Factor VIII Gene Into the Nucleus of Liver Cells Using an Altered, Non-infectious Virus (AAV) as a "Shuttle". | NCT03588299 | Contradiction |
6,505 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- legally competent,
- at least 18 years of age
- persons able to read and understand spoken and written information in Danish or
English.
- One or more facial telangiectasia
Exclusion Criteria:
- wounds or ulcers in a... | D-OCT of Facial Telangiectasia Treated With IPL | NCT04274842 | Entailment |
3,128 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Suffer from at least two of the following ocular symptoms: burning, stinging,
excessive tearing, dryness, grittiness, foreign body sensation ( including patients
suffering from blepharitis).
- Use artificial tears or any other treatment for these s... | Study to Assess the Safety and Patients' Satisfaction of Tears Again* in the Treatment of Dry Eye Symptoms | NCT00535054 | Contradiction |
6,929 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
1. Adult males or females Aged 45 years through 85 years (have not had their 86th
birthday)
2. Men and women with a diagnosis of Alzheimer's disease according to the clinical
criteria
3. Women must be of non-childbearing potential, surgicall... | PMZ-1620 (Sovateltide) in Mild to Moderate Alzheimer's Disease | NCT04052737 | Entailment |
4,030 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- knee osteoarthritis >3 months in clinical and radiographic signs
- VAS for pain >50mm
Exclusion Criteria:
- Hepatitis B
- Hepatitis C
- HIV
- pregnancy
- drug abuse
- other intra-articular inje... | Autologous Conditioned Serum: Functional and Clinical Results | NCT03850080 | Entailment |
6,732 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients with diagnosis of haemophilia A, treated with KOGENATE Bayer/FS as their only
source of FVIII, decision taken by the investigator to administer KOGENATE Bayer/FS.
For pretreated patients with more than 100 exposure days an inhibitor assessment
... | EFFEKT - Efficacy and Safety of Long-term Treatment With KOGENATE Bayer/FS | NCT00874926 | Contradiction |
350 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Informed consent form (ICF) dated and signed.
2. Age: ≥18 and <40 years old.
3. AFC ≥5 and <20.
4. AMH ≥1.1 ng/mL and <2.5 ng/mL, performed in the 12 months prior to inclusion.
5. Body Mass Index (BMI): ≥18.5 Kg/m2 and <30 Kg/m2.
6... | Effect of Different Ovarian Stimulation Protocols on Endometrial Receptivity | NCT03755973 | Contradiction |
6,052 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patients have heartburn with non-erosive gastroesophageal reflux disease.
Exclusion Criteria:
- Patients have diseases which interfere with evaluation of the efficacy and safety in
this study.
- Patients are receiving and/or have received p... | Famotidine in Subjects With Non-erosive Gastroesophageal Reflux Disease | NCT00141960 | Entailment |
251 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women at or under the age of 35 years.
- Normal thyroid stimulating hormone and prolactin levels.
- Normal ovulatory cycles (25-35 interval days), together with proven patent fallopian
tubes at hysterosalpingography or laparoscopy done within six cy... | Poor Ovarian Stimulation Response in In Vitro Fertilization (IVF) Program | NCT02640976 | Contradiction |
1,481 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- (1) age over 65 years old; (2) does not use enteral tube feeding; (3) no serious
mental or cognitive conditions; no aphasia
Exclusion Criteria:
- (1) age under 65; (2) use enteral tube feeding; (3) subjects with serious mental or
cognitive... | The Accuracy of Swallowing Disturbance Questionnaire in Screening Inpatient Elderly | NCT03816098 | Entailment |
4,258 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Male infertile patients with a pathological spermiogram according to WHO criteria
Exclusion Criteria:
- Drugs affecting sperm quality
- Patients with chromosomal anomalies affecting sperm quality (e.g. Klinefelter-
Syndrome)
- S... | Expressive Writing in Male Infertility | NCT00385346 | Entailment |
4,195 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Normal: People with no lung lesions in chest X-ray and St. George's Respiratory
Questionnaire score <25, and post bronchodilator FEV1/FVC (forced expiratory volume at
one second/forced vital capacity) >= 0.7 and FEV1 >= 80% and FVC >= 80%.
- Chroni... | Impact of Air Pollution on Chronic Respiratory Diseases | NCT03813810 | Contradiction |
1,803 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Male or female age 65 and older
- Non-smokers
- Weight loss >3% body weight over 6-12 months
- BMI ≤ 25
- Living independently or in an assisted living facility
Exclusion Criteria:
- Medical conditions that would lead... | Nutritional Supplementation in the Elderly With Weight Loss | NCT04350762 | Contradiction |
3,843 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Pain in the knee joint during more than a half day assessed by Visual Analog Pain
Scale (score more than 40 mm)
- At least three of the following 6 criteria: 20-85 years of age, stiffness lasting less
than 30 minutes, crepitus, bony tenderness, bon... | The Evaluation of Safety and Effectiveness of Intraarticular Administration of Autologous Stromal-Vascular Fraction of Adipose Tissue Cells for Treatment of Knee Joint Arthrosis | NCT04050111 | Entailment |
5,658 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Chronological age (CA) between 3 and 10 for girls
- Chronological age between 3 and 12 for boys
- Height for CA below - 2 SD
- Birth length for CA below -2SD
Exclusion Criteria:
- Endocrine disease except well-substituted hypothy... | Genotropin Treatment in Short Prepubertal Children With Intra-Uterine Growth Retardation | NCT01073605 | Contradiction |
2,431 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- Age group of 18 to 65 years
- Clinicoradiological suspicion of sarcoidosis where EBUS-TBNA is being planned
- Enlarged hilar and mediastinal lymph nodes >10 mm (any axis) on computed tomography of
the chest
Exclusion Criteria:
- ... | Effect of the Number of Needle Revolutions Inside the Node on the Diagnostic Yield of EBUS-TBNA in Sarcoidosis | NCT02875756 | Contradiction |
3,651 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:Clinical diagnosis of Menorrhagia
- Must be able to swallow tablets
Exclusion Criteria:
- Endometrial abnormality
- Pelvic infection
- Pregnancy
- Breast Feeding
- Requirement for birth control
- Known intole... | The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders | NCT00904709 | Entailment |
2,496 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- Normal subjects, patients with deficient binocular vision, patients with color vision
disorders
Exclusion Criteria:
- phthisis, enucleations
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 1 Year ... | Autostereoscopic Dynamic Near Vision Testing | NCT04606355 | Entailment |
3,016 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Male subjects 18 to 50 years of age, inclusive.
- Molecular documentation of the full fragile X mutation.
Exclusion Criteria:
- Subjects with a history of seizure disorder who are, in the opinion of the
Investigator and Medical Monitor, not... | A Study to Assess the Tolerability of a Single Dose of STX107 in Adults With Fragile X Syndrome | NCT01325740 | Contradiction |
772 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- the presence of knee osteoarthritis Grade 2 and Grade 3 based on Kellgren Lawrence
Classification,
- volunteering to participate in the study.
Exclusion Criteria:
- the presence of active synovitis,
- participation physiotherapy... | Effects of Closed and Open Kinetic Chain Exercises | NCT04186143 | Contradiction |
6,961 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Informed volunteer consent, patient consent
- Male or female, aged between 18 and 100 years of age
- Able (in the Investigator's opinion) and willing to comply with all study requirements
- Willing to allow his or her General Practitioner (GP) to be ... | Cerebral Haemodynamic Changes During Cognitive Testing: A fTCD Study | NCT03134963 | Entailment |
5,170 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
Ambulatory male and female residents with osteoporosis or low bone mass (at risk for
fracture) ages 65 and older will be considered if:
- Reside in long-term care institution (nursing home or assisted living facility); and
- HaveOsteoporosis: (1) by bone dens... | Preventing Osteoporosis Using Denosumab | NCT02753283 | Contradiction |
4,482 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women with intact uterus, regular menstrual cycles and no previous or current
climacteric symptoms.
Exclusion Criteria:
- Pregnancy or lactation.
- Previous pelvic infections.
- Abnormal bleeding.
- Abnormal uterine ... | Assessment of the Transfer of Using Levonorgestrel Intrauterine System (LNG IUS) as a Contraceptive to Using it as Part of Hormone Replacement Therapy (HRT). | NCT00185458 | Contradiction |
6,933 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- diagnosis of mild cognitive impairment or Alzheimer's disease
- availability of cohabitating study partner without cognitive impairment
- consent of primary care physician
Exclusion Criteria:
- history of stroke
- history of coro... | Dietary Treatments for Cognitive Impairment in Older Adults | NCT02521818 | Entailment |
6,287 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Outpatients ≥ 18 years presenting to Cleveland Clinic Health System in Ohio and
Florida who test positive for COVID-19 having any of the following symptoms
1. Fever or chills
2. Shortness of breath or difficulty breathing
3. ... | Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation | NCT04342728 | Entailment |
2,586 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- ages 4-10 years old
- undergoing elective umbilical or inguinal hernia repair surgery
- ASA Physical Status = 1
Exclusion Criteria:
- None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Su... | The Impact of Medical Clowning on Pain and Stress Level in Pediatric Patients Undergoing Hernia Repair Surgery LAUGH Study. | NCT01622218 | Contradiction |
357 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age of women from 18-40 years at the time of recruitment (not beyond 40th birthday)
- Absence of fever
- Gestation less than 12 completed weeks as defined by pelvic ultrasound
- Presence of intrauterine gestational sac(s) if an urine pregnancy test i... | Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage | NCT02128685 | Contradiction |
5,534 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion criteria
- Diagnosis of Giant cell arteritis (GCA) according to the revised American College of
Rheumatology criteria
- GCA diagnosis confirmed by either temporal artery biopsy revealing features of GCA; or
evidence of cranial GCA by doppler-ultrasound; or cra... | A Study to Evaluate Guselkumab for the Treatment of Participants With New-onset or Relapsing Giant Cell Arteritis | NCT04633447 | Entailment |
581 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age 18 years+
- Diagnosis of IPUVI on initial ultrasound
Exclusion Criteria:
- Current mental health condition (anxiety, depression, eating disorder). The condition
will be considered current if it has required one or more consultations wit... | Psychological Impact of Predicting Early Pregnancy Outcomes in Women With Pregnancy of Uncertain Viability | NCT03264170 | Entailment |
5,404 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Female
- Aged 18 years and over
- Regular menstrual cycles
- Owns a compatible smart phone i.e. iPhones® and AndroidTM phones equipped with
Bluetooth® 4.0/BLE
- Willing to use their own smartphone for the duration of this stu... | Menstrual Cycle Symptom Tracking | NCT04756739 | Entailment |
3,234 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Diagnosis of moderate to severe dry eye syndrome with or without Sjogren's syndrome or
other autoimmune disease
Exclusion Criteria:
- Intraocular or refractive surgery in the study eye within 3 months prior to study
start
- Unw... | Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005) | NCT00502073 | Entailment |
3,833 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- patients with knee osteoarthritis, treated by a participating physiotherapist within a
predefined period
Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Knee Osteoarthritis Care: A Quality Improvement Intervention in Physiotherapists | NCT02177162 | Entailment |
1,879 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. The subject is Chinese
2. The subject is greater than 50 years of age
3. The subject satisfies one or more of the following criteria:
- has (had) a history of dyspepsia of at least 4 weeks or more. Dyspeptic symptoms
include bloa... | Confocal Endomicroscopy Detection of Gastric Preneoplasia and Neoplasia | NCT01384201 | Entailment |
4,122 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Having persistent cough that lasts longer than 3 weeks following URTI
2. Currently being a non-smoker
3. Having normal spirometry (FEV1>or= 80% predicted)
4. Obtain consent form
Exclusion Criteria:
1. Having cough more than 8 weeks
... | Effect of Oral Procaterol on Postinfectious Persistent Cough | NCT02349919 | Contradiction |
2,098 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Clinical symptoms consistent with IPF with onset between 3 months and 36 months prior
to screening
- Worsening as demonstrated by any one of the following within the past year:
1. >10% decrease in FVC % of predicted,
2. Worsening... | Gleevec Idiopathic Pulmonary Fibrosis (IPF) Study | NCT00131274 | Entailment |
4,704 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | For participants with major depressive episode:
Inclusion criteria:
- female sex
- current diagnosis of a major depression episode
- minimum age of 18 years
- regular menstrual cycle.
Exclusion criteria:
- Pregnancy less than one year ago;
... | Depressive Symptoms and Subjective Stress in the Course of the Menstrual Cycle - an Ambulatory Assessment Study. | NCT04086316 | Entailment |
6,090 | 45 | A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is o... | My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor dia... | Inclusion Criteria:
- Down syndrome without mosaicism
- age 3 to 30 months
- weight over 4 kg
- possible assessment by the revised Brunet-Lezine scale
Exclusion Criteria:
- history of leukemia
- West syndrome or non-stable epilepsy
... | Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome | NCT00294593 | Entailment |
1,222 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- patients diagnosed as exudative pleural effusion according to Light criteria .informed
written consents were taken from all patients enrolled in the study
Exclusion Criteria:
- patients who refused participation ,patients unfit for medical thoracoscopy... | Efficacy And Safety Of Thoracoscopic Cryobiopsy In Patients With Undiagnosed Exudative Pleural Effusion | NCT04761003 | Entailment |
5,411 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women between the ages of 18-45 (inclusive) not intending to get pregnant during the
next year
- Women complaining of heavy menstrual bleeding over several consecutive cycles
- Women without structural or histological abnormality of the uterus, or w... | Mirena or Conventional Medical Treatment for Menorrhagia | NCT00864136 | Entailment |
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