id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
values | statement_pol stringclasses 50
values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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495 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Gestation up to 63 days
- General good health
- Willingness to provide contact information for follow-up
- Absence of conditions which contraindicate the use of mifepristone and misoprostol for
pregnancy termination
Exclusion Cr... | Acceptability and Feasibility of Medical Abortion Using Mifepristone and Buccal Misoprostol | NCT00386282 | Contradiction |
942 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- knee osteoarthritis according to the criteria of knee osteoarthritis of American
College of Rheumatology.
- Having felt a painful push in the last 6 months.
- Visual Analogic Scale pain > 4 on a 0 to 10 scale.
- having a Radiographic sco... | Multimodal Imaging of Subchondral Bone in Knee Osteoarthritis : Predictive Model | NCT03294408 | Entailment |
2,986 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | INCLUSION CRITERIA
Inclusion criteria for healthy volunteers:
1. Ages 18-65
2. Either gender and all ethno-racial categories
3. Capacity to provide informed consent
4. Female participants are expected to use an effective method of birth control
throughou... | Novel Clinical Target in Fragile X Syndrome | NCT04314856 | Contradiction |
4,209 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
Healthy Volunteers:
- Over 18 years old
- Measurable cough reflex sensitivity
- No current or past history of chronic cough or chronic respiratory disease.
- No symptoms of gastro-oesophageal reflux disease, asthma or post-nasal drip.
... | Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity | NCT00858624 | Contradiction |
3,929 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria: - Diagnosed with knee OA as determined by American College of
Rheumatology (ACR) criteria - Pain defined by a level of greater than 30 mm on a 100 mm
Visual Analogue Scale (VAS) - No evidence of active effusion or inflammatory flare,
confirmed by investigator - Must exhibit r... | Treatment for Patients With Osteoarthritis (OA) of the Knee | NCT00110916 | Entailment |
703 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- adults over 18 who agreed to participate in the study and signed an informed consent
form.
- Patients who went through partial or complete arthroplasty of the hip due to traumatic
or degenerative changes - respectively.
Exclusion Criteria:... | The Histological Effect of Various Microfracture Techniques on Human Chondral & Sub-chondral Tissue - an Ex-Vivo Study | NCT03016299 | Contradiction |
2,996 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Volunteer has a confirmed learning disability (permanent intellectual impairment);
- Registered with a general practice in Leicester, Leicestershire or Rutland, UK;
- Participant and/or carer has sufficient English language skills to enable fully
in... | Diabetes Screening & Prevention for People With Learning (Intellectual) Disabilities:STOP Diabetes Study | NCT02513277 | Contradiction |
2,737 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Inguinal hernia with surgical indication for surgical repair
Exclusion Criteria:
- History of urologic surgery and/or radiotherapy
- Recurrence of inguinal hernia
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old... | Testicular Vascular Evaluation in Patients Undergoing Inguinal Hernia Repair | NCT03056027 | Entailment |
3,044 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Hospitalization on General Internal Medicine ward at St. Michael's Hospital
Exclusion Criteria:
- Transfer to another service
- Death during admission
- Remains in hospital past dates specified in study protocol
No condition on gender to be ... | Automated Versus Conventional Hospital Discharge Summaries and Prescriptions | NCT00670865 | Entailment |
2,116 | 13 | A 24-year-old man comes to the office complaining of infertility. He and his wife have been trying to conceive for the last 18 months. Medical records of his wife showed no abnormalities. The patient doesn't smoke and takes no medications. Height is 185 cm and weight is 77 kg. Heart and lung sounds are normal. Th... | I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was norm... | Inclusion Criteria:
- All couples consisting of male and female partner undergoing CC or letrozole cycle
plus IUI at a single infertility center (Midwest Fertility Specialists)
- The female partner must be aged 21-39
- Infertile couples include those with a diagnosis(s) ... | Study Evaluating the Timing of Intrauterine Insemination in Relation to Positive Home Ovulation Prediction Kit | NCT02294773 | Contradiction |
4,961 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Essential tremor
Exclusion Criteria:
- MRI-incompatible metal objects in the body (e.g. cardiac pacemakers)
- other main neuropsychiatric co-morbidity
- pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accept... | tSMS in Essential Tremor | NCT03780426 | Entailment |
6,396 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Fever and/or
- Cough and/or
- Dyspnoea
Exclusion Criteria:
- No one
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Accuracy of Lung Ultrasound in the Diagnosis of covid19 Pneumonia | NCT04370275 | Entailment |
1,552 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Solid mass lesions under going endoscopic ultrasound (EUS)
Exclusion Criteria:
- Coagulopathy
- Age below 18 years
- Cystic or solid-cystic lesions.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the... | Comparison of "Wet Suction" Technique to Contemporary "Dry Suction" Technique Using a 22 Gauge Needle for EUS FNA | NCT01720745 | Contradiction |
6,264 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patient with an acute SARS-CoV-2 infection, confirmed by PCR or typical CT images,
requiring hospitalization in a COVID unit at the Rouen University Hospital (pneumonic
form requiring oxygen therapy < 4 L/min.)
- Rouen University Hospital staff fre... | Antiviral T Lymphocyte Immunity During Acute COVID-19 Infection | NCT04707820 | Contradiction |
5,128 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Ambulatory Indian postmenopausal women with osteoporosis
- greater than 5 years postmenopausal
- aged 55 to 75 years old
- absolute bone mineral density value consistent with a T-score less than -2.5 and
greater than - 4.0 at the either ... | A Study in Indian Postmenopausal Women With Osteoporosis to Evaluate the Efficacy and Safety of Denosumab | NCT01495000 | Contradiction |
995 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
Patients aged ≥ 40 years with symptoms of knee osteoarthritis
Exclusion Criteria:
rheumatoid arthritis, spondyloarthropathy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject mu... | Strontium Ranelate and KOA | NCT03937518 | Entailment |
1,831 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Healthy volunteers
- Patients undergoing clinical indicated MRI
Exclusion Criteria:
- Patients with contraindication for MRI
- Pregnant women will be excluded from this study
No condition on gender to be admitted to the trial.
Accepts Health... | Clinical Testing of New MR Pulse Sequences | NCT00590252 | Entailment |
5,660 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Ages 8 to 17 years old
- Overweight, defined as BMI ≥ 85th%tile for age and gender
- At least two CV risk factor typical of the metabolic syndrome including insulin
resistance, high or borderline blood pressure, low HDL, high TG
- Insuli... | Nutritional Treatment of Overweight Adolescents With Cardiovascular Risk Factors (PowerUp) | NCT00477477 | Contradiction |
3,394 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Type 2 diabetes patients
2. HbA1C > 7%
3. Duration of diabetes: 0.5 to 10 years
4. Subjects ≥ 30 and ≤70 years of age
5. BMI: 22 to 35 kg/m2
6. Diet controlled diabetic. Only treatment with metformin will be allowed
7. N... | Meal Timing on Postprandial Glucose, Insulin and GLP-1 in Type 2 Diabetes | NCT01977833 | Contradiction |
6,788 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients diagnosed with severe Hemophilia A.
- Age ≥18 years old
- Patients able to read and write
- Patients receiving Factor VIII substitute therapy, either on-demand or as secondary
prophylaxis.
- Patients under the same t... | 2-cohort Study of Adult Patients With Severe Hemophilia A in Greece | NCT02319070 | Entailment |
4,062 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Signed informed consent.
- Completed the SH-NEN-0003 study with relief of upper GI symptom. Relief is defined as
"last 7 days with a diary assessment of None or Minimal, but allowing up to 2 days to
be rated as Mild during the 7-day period".
... | Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs | NCT00241553 | Entailment |
6,621 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- The study population will consist of all patients diagnosed with hemophilia (D66.9
(hemophilia A) D67.9 (hemophilia B) in International Statistical Classification of
Diseases and Related Health Problems (ICD-10) that have been registered in the Malmö
... | Treatment Patterns And Outcomes In Patients Treated With Benefix Or Refacto/Refacto AF - A Swedish Cohort Study | NCT02740413 | Contradiction |
3,914 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Men or women
- Women of child bearing potential must not be pregnant during the study and must use
two forms of birth control
- Men and their female partners must use two forms of birth control
- Clinical and radiographic evidence of chr... | A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee | NCT01554579 | Entailment |
2,181 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
1. Has negative results of an FDA Emergency Use Authorized COVID-19 molecular assay for
detection of SARS-CoV-2 RNA from a respiratory specimen;
2. History of symptomatic gout defined as:
1. ≥ 3 gout flares within 18 months of Screening or
... | A Study of SEL-212 in Patients With Gout Refractory to Conventional Therapy II | NCT04596540 | Contradiction |
5,807 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Subjects whose age was above 15 years old.
Exclusion Criteria:
- Subjects having problem in opening their mouth (due to non-oral ulcer cause) or
undergoing intermaxillary fixation where oral examination was not possible.
No condition on gender to be ad... | Oral Ulcer Prevalence: Hospital-based Cross-sectional Study | NCT03167632 | Entailment |
684 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Patiens newly diagnosed having Hereditary Hemochromatosis
Exclusion Criteria:
- Age < 18 yrs.
- Not obese (BMI <30)
- Not consuming alchol beverages,
- Not affected by systemic diseases and known hepatic viruses
No condition on g... | Clinical Management of Hereditary Hemochromatosis: Phlebotomy vs. Erythrocytoapheresis | NCT00440986 | Entailment |
3,469 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- In order to be eligible for the study, the individual must be 40 years of age or
older; have a DRG Code of T2DM, GFR of 15-89 ml/min/1.73m2 and a BMI >30 kg/m2. The
participant's physician of record will have verified that his/her patient can safely
... | Diabetes CKD Lifestyle Technology Study | NCT02266823 | Entailment |
5,972 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Willing and able to sign informed consent
- Persistent GERD symptoms after minimum 8 week trial on daily PPI
Exclusion Criteria:
- Unwilling to sign informed consent
- Prior anti-reflux surgery
No condition on gender to be admitted to the tr... | A Prospective, Observational Study of the PPI Non-responder | NCT03282084 | Entailment |
1,044 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
To be considered eligible for enrolment into the study, subjects must;
1. Be aged 30 to 75 years (inclusive),
2. Be willing to provide informed consent,
3. Have a BMI between 18.5 and 32 kg/m2,
4. Have documented diagnosis of primary osteoarthriti... | An Intervention Study Evaluating the Effects of a Raspberry Leaf Extract in an Osteoarthritic Population. | NCT03703024 | Entailment |
4,745 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- right-handed subjects
- 19-65 years of age
- debilitating unilaterial or bilateral tinnitus
- Experiencing the presence of phantom auditory preception for >6 months
- Tinnitus Handicap Questionnaire score of >30
Exclusion Criteri... | Using PET-CT to Target and Validate Low-frequency TMS as Treatment for Tinnitus | NCT00329524 | Contradiction |
5,559 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Growth hormone deficiency clinically and biochemically demonstrated
Exclusion Criteria:
- Children affected by multiple pituitary hormone deficiency or receiving any other kind
of hormonal replacement therapy or drug and GHD children with a shorter fol... | Three-times-weekly Versus Daily Growth Hormone (GH) Treatment in naïve GH-deficient Children | NCT03033121 | Contradiction |
6,643 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- patients suffering from moderate or severe hemophilia A (FVIII <5%, ≥ 12 years old)
- factor treatment with ADVATE© or ADYNOVI©
- use of myPKFiT
Exclusion Criteria:
- patients suffering from other coagulopathies
- participants wi... | Association Between Individual Clotting Factor Level Monitoring and the Risk of Bleeding Whilst Physical Active Conditions | NCT04845555 | Contradiction |
6,016 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Men and women ages 18-75.
2. Willing to participate and sign an inform consent.
3. Having heartburns, acid regurgitations and/or chest pain at least twice a week for at
least 3 months.
4. Ability to stop anti-acid and anti-pain medications ... | A Comparison of Factors of Symptoms Generation and Evaluation of Role of Biofeedback in Patients With Different Types of Functional Esophageal Disorders (Functional Heartburn and Functional Chest Pain) | NCT00471796 | Entailment |
5,803 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | - INCLUSION CRITERIA
This study will recruit a convenience sample of 50 volunteers (25 current smokers with at
least 5 years of smoking history, 25 never smokers). Current smokers are defined as
individuals who have smoked more than 100 cigarettes in their lifetime and have smoked 5 or
... | Cigarette Smoking and Oral Microbiota | NCT01862809 | Entailment |
5,309 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- new pain in spine (within 6 months)
- x-ray verified low energy spinal fracture(s)
Exclusion Criteria:
- less than 20% or more than 90% reduction of the vertebral height
- lack of pain at fracture level
- no need for continuous a... | Percutaneous Vertebroplasty Versus Conservative Treatment of Pain | NCT00203554 | Entailment |
6,655 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Congenital hemophilia A; FVIII </=5% or congenital hemophilia B; FIX </=5%;
- Birth date on or after January 1, 2010;
- Care established at one of the participating HTCs;
- Co-enrollment in the ATHNdataset; and
- Parent or authorized guar... | ATHN 8: PUPs Matter Study | NCT03818529 | Contradiction |
2,884 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Subjects referred to the electromyography laboratory for ALS.
Exclusion Criteria:
- Patients with known comorbid myopathy or neuropathy will be excluded from the study.
- Patients unable to provide their own consent will be excluded.
No condition on gen... | Neuromuscular Ultrasound in ALS | NCT01785550 | Entailment |
4,625 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Patient Inclusion Criteria:
- Age ≥ 18 years old
- Sign the informed consent form
- BMI ≤ 40
- A.S.A. Class < III or IV
Disease Inclusion Criteria:
- Ovarian cyst (enucleation/oophorectomy)
- Prophylactic bilateral oophorectomy
... | Robotic Assisted Surgery for Treatment of Gynecological Diseases: Pilot Study | NCT03093675 | Entailment |
356 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Subfertile women undergoing frozen-thawed embryo transfer with at least previously
failed one ICSI cycle.
- Age between 20-35 years.
- Women with endometrium thickness between 8-14 mm on D15 of the frozen embryo transfer
cycle
... | Assessment of Endometrial and Sub-endometrial Vascularity Before and After PRP Infusion in Frozen Embryo Transfer Cycles | NCT04247204 | Contradiction |
5,384 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Non-pregnant, non-planning pregnancy, non-lactating non-menopausal females at least 18
years of age.
- Patients with a clinical diagnosis of functional Menorrhagia during the last 6 months.
- Patients who are eligible and able to participate in the ... | Therapeutic Equivalence Trial of Two Hormonal-IUDs in Patients With Heavy Menstrual Bleeding | NCT01695902 | Entailment |
2,284 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Evidence of signed and dated informed consent/assent document(s) indicating that the
participant (and/or his parent/legal guardian) has been informed of all pertinent
aspects of the trial.
- Phenotypic evidence of duchenne muscular dystrophy (DMD) ... | A Study to Assess Dystrophin Levels in Participants With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD) | NCT03648827 | Contradiction |
4,849 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Patients with a confirmed diagnosis of Cushing's Disease (persistent or recurrent) as
evidenced by increased 24-hour urine free cortisol (UFC), normal or increased morning
plasma Adrenocorticotropic Hormone (ACTH), and pituitary origin of excess ACTH.
... | Safety and Efficacy of LCI699 in Cushing's Disease Patients | NCT01331239 | Contradiction |
3,893 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Subjects diagnosed with osteoarthritis of unilateral or bilateral knee osteoarthritis
who meet the criteria defined by the American College of Rheumatology for at least 4
months prior to the study. In bilateral knee osteoarthritis, only the knee with more
... | New Hydroxyethyl Cellulose Hydrogel for the Treatment of the Pain of Knee Arthrosis | NCT04061733 | Entailment |
5,102 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Vertebral compression fracture Inclusion Criteria:
older than 65 years osteoporosis diagnosed by a bone mineral density test of the lumbar
spine (T-score < -2.5; T: peak bone mass) thoracic-lumbar VCF on radiography without
displacement
Vertebral compression fracture Exclusion Criteria... | The Spine Kinematics and Center of Pressure Excursion During Functional Task Vertebral Compression Fractures Subjects | NCT04135755 | Contradiction |
2,002 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Age between 18 to 75 years old
2. Primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or
poorly differentiated) confirmed pathologically by endoscopic biopsy
3. Locally advanced tumor in the middle third stomach（cT1-4a, N-/... | Randomized Controlled Trials on Clinical Outcomes of Totally Laparoscopic Versus Laparoscopy Assisted Total Gastrectomy for Gastric Cancer | NCT03006263 | Entailment |
3,572 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | - INCLUSION CRITERIA:
- Clinical diagnosis of active Lyme disease at the time of the initial NIH evaluation
based on the CDC case definition. Study physician will review history to confirm
probable cases.
- Subjects must maintain a private physician for non-protocol re... | Evaluation, Treatment, and Follow-up of Patients With Lyme Disease | NCT00028080 | Entailment |
5,257 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | - INCLUSION CRITERIA - LONGITUDINAL STUDY GROUP:
- For the respective groups, individuals need to be either:
1. Diagnosis of Osteoporosis or Osteopenia AND have received bisphosphonate therapy
for at least 5 years
2. Diagnosis of Osteoporosis or Osteopenia ... | Bisphosphonate Users Radiographic Characteristics of the Hip (BURCH) Study | NCT01360099 | Entailment |
1,564 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- to be diagnosed according to CASPAR or ACR/ EULAR 2010 criteria for patient groups
- taking regular medication for patient groups,
- have complaints related to hand / wrist joints for patients groups,
- have no complaints related to upper extremity f... | Comparison of Hand Functions and Wrist Proprioception in Patients With and Without Psoriatic Arthritis | NCT04553302 | Contradiction |
765 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Men and women of all races
- Capable of giving informed consent
- Age 18-60 years
- Body mass index (BMI) between 30-40 kg/m2
- Hypertension defined as two or more seated blood pressure readings >130/80 mmHg or use
of anti-hy... | Angiotensin 1-7 in Obesity Hypertension | NCT03604289 | Contradiction |
2,381 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Confirmed diagnosis of DMD
- Male.
- Four years of age or older.
- Ability to walk independently for five minutes to 10 minutes at self-selected speed.
- Ability to cognitively understand directions for testing procedures.
Exclus... | Biomechanical Analysis of Gait in Individuals With Duchenne Muscular Dystrophy | NCT00312247 | Entailment |
6,329 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Both sexes aged 18 years and older.
2. Clinically diagnosed influenza or ARVI mild or moderate severity.
3. Patient's body temperature ≥37.5ºС and at least 1 symptom from Modified Jackson Scale
estimated more than 2 points.
4. Uncomplicated... | Study to Assess Efficacy and Safety of XC221 200 mg in the Treatment of Influenza or Other ARVI | NCT03830905 | Entailment |
3,960 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Symptomatic knee osteoarthritis presenting to physician's office
- Radiographic evidence of knee osteoarthritis
- Age 18 years or older
- Failed minimum of 3 months of non-operative treatment, including, but not limited to,
Tylenol, anti... | Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis | NCT01557868 | Entailment |
2,731 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- 18-75 years old
- groin hernia repair
- written consent
- ASA 1-3
- BMI 18-35
Exclusion Criteria:
- unable to communicate in Danish
- relevant drug allergy
- pain medication in the last 24 hour... | The Efficacy of Transversus Abdominis Plane Block After Groin Hernia Repair | NCT01052285 | Entailment |
1,660 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- fluent in English, capacity to provide consent,
- over the age of 18 years old, with no previous injury to either hand or wrist
Exclusion Criteria:
- pregnancy and presence of neurological disorders, rheumatoid arthritis or comorbid
health ... | Dynamic 4DCT to Examine Wrist Carpal Mechanics | NCT04402502 | Entailment |
6,355 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Gender: Either male or non-pregnant, non-lactating female aged > 18-70
- Patients with RT-PCR confirmed diagnosis of COVID-19
- Patients with mild to moderate COVID-19 infection having either one of the following
criteria: oPaO2/FiO2:200-300 OR Resp... | Effect of a Combination of Treatment of Reginmune Capsule and Immunofree Tablets in the Treatment of Mild to Moderate COVID-19 Patients | NCT04494204 | Entailment |
4,914 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Severe essential tremor despite the optimal medical management
- Age between 18 and 75 years
- Normal MRI scan
- Mattis Dementia Rating Scale (MDRS) score ≥ 130
- Affiliation to the social security
- Signed informed consent
... | Optimization of VIM Targeting in Essential Tremor Surgery | NCT03760406 | Entailment |
2,331 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Diagnosis of DMD confirmed
- Ambulant
- Corticosteroid therapy for at least one year prior to study day 1 and on a stable dose
and schedule for at least 6 months prior to study day 1
- Evidence of muscle weakness by clinical assessment
... | Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy | NCT01099761 | Entailment |
4,146 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Males with no elongated spermatids or spermatozoa present but with round spermatids
present on TESE (Testicular Sperm Extraction)
- Male diagnosed with non-obstructive Azoospermia
- Male partner ≥18
- Female partner greater than 18 years... | Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples | NCT04298255 | Contradiction |
4,457 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Confirmed diagnosis of lateral epicondylitis based on 2 or more of the following
diagnostic criteria: tenderness over the lateral epicondyle; pain with resisted wrist
extension; pain with resisted long finger extension.
- Symptoms lasting a minimum... | Comparison of Intra-articular and Intra-tendinous Injections for Treatment of Lateral Epicondylitis | NCT02986646 | Contradiction |
4,526 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Having low back pain LBP during menstrual phase (days 1-6) of the menstrual cycle.
- Suffering from low back pain during all menstrual cycles in the year before the study.
- No back pain or low back paiun at times other than the menstrual phase.
- Pa... | Effect of Functional Lumbar Stabilization Exercises in Women With Menstrual Low Back Pain | NCT01932723 | Contradiction |
3,514 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Previously diagnosed (e.g. more than 6 months ago) primary adrenal insufficiency with
a stable daily glucocorticoid substitution dose for at least 3 months prior to study
entry
- Signed informed consent to participate in the study.
Exclusi... | Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency | NCT00915343 | Contradiction |
1,629 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Healthy male voluntary subject, aged 18 to 40 inclusive.
2. Right-handed subject verified by the Edinburgh test.
3. Body mass index (BMI) between 18 and 25 kg/m2 inclusive.
4. Blood pressure and heart rate considered clinically normal by the investigato... | Study of Somatosensory Responses During Millimeter Waves Application | NCT04801550 | Contradiction |
6,234 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- COVID-19 positive PCR test
- a COVID-19 ICD-10-CM diagnosis code during a healthcare visit, or a COVID-19 positive
antibody test
- Must be a patient in one of the 21 participating healthcare systems
Exclusion Criteria:
- N/A
No ... | The C3I COVID-19 Project | NCT04506528 | Contradiction |
5,003 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Patients suffering from severe and disabling ET with serious impact on their quality
of life (QoL).
- 18-70 years old
- Free of evolutive and untreated psychiatric disorder
- Tremor must be predominant in the upper limbs although it can ... | Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives | NCT02264925 | Entailment |
5,529 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria for Classification criteria:
1. Adult patients aged >18 years. There is no upper age limit.
2. Ability to give informed consent. If the patient is unable to give informed consent as
a result of death or physical incapacity, then informed assent from next of kin.
... | American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis | NCT01066208 | Entailment |
1,573 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Is male or female <17 years of age at the time of dosing.
2. Subject 2 to <17 years of age, be in at least the 25% for weight according to the
Center for Disease Control pediatric growth charts and weighs at least 28 lb at the
time of dosing with st... | Evaluate The Pharmacokinetics and Safety Of Oxycodone Oral Solution In Pediatric and Adolescent Subjects | NCT01959204 | Contradiction |
1,782 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- A consecutive series of patients with symptoms suggestive of GERD were enrolled from
the Gastroenterology outpatient clinic in our institution. The typical GERD symptom
was defined as heartburn and/or acid regurgitation of at least three episodes per week
... | CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing | NCT00354757 | Contradiction |
4,093 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- DSM 5 Parasomnia Disorder
- at least one parasomnia event per week
- daytime fatigue or sleepiness
- 6 months in duration
Exclusion Criteria:
- current use of agents known to triggers parasomnias such as Lithium carbonate,
... | Impact of Cognitive Behavioral Therapy on Parasomnias | NCT04633668 | Entailment |
6,938 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Patients with memory or other cognitive impairments suggestive of dementia syndrome
- those with a formal diagnosis of dementia, of any type.
Exclusion Criteria:
- Patients and carers who are already involved in concurrent research
- If the ... | Dementia Early Recognition and Response in Primary Care | NCT00866099 | Entailment |
4,167 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. A history of episodic wheezing, chest tightness, or shortness of breath consistent
with asthma, or physician diagnosed asthma.
2. Specific allergy to house dust mite Dermatophagoides farinae confirmed by positive
immediate skin test response.
... | Study of Dust Mite Inhalation in Humans | NCT00448851 | Contradiction |
5,961 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- persistent or recurrent symptoms despite continuous medical treatment, at least one
typical reflux symptom (heartburn/ regurgitation/dysphagia/epigastric pain) and/or at
least one atypical reflux symptom (cough/ asthma/hoarseness/distortion of taste),
... | Full-Thickness-Gastroplication For The Treatment Of Gastroesophageal Reflux Disease GERD | NCT01453985 | Contradiction |
6,664 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Males aged 12 to 50 years (US and Argentina)
- Males aged 18 to 50 years (other countries)
- Subjects with severe hemophilia A (<1% FVIII:C) as confirmed by the central lab from a
sample obtained at least 96 hours after FVIII administration wash-out... | Trial to Evaluate the Effect of Secondary Prophylaxis With rFVIII Therapy in Severe Hemophilia A Adult and/or Adolescent Subjects Compared to That of Episodic Treatment | NCT00623480 | Contradiction |
308 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- a history of ovarian surgery;
- previous treatment using conventional protocols that yielded less than three oocytes;
- antral follicle count of less than 5 on menstrual cycle day 2-3; and basal serum FSH
concentration between 10 and 19 IU/l.
... | GnRh Antagonist Protocol With Delayed Start Stimulation in Patients With Poor Ovarian Response | NCT03134690 | Contradiction |
4,143 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Diagnosis of cancer
2. Dyspnea with an average intensity level >3/10 on the numeric rating scale over the
past week
3. Clinical or radiologic history of lung/pleural involvement (primary or metastatic),
lymphangitic carcinomatosis or airw... | Dexamethasone Dyspnea Study | NCT01670097 | Contradiction |
5,216 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Osteoporosis patients
Exclusion Criteria:
- eGFR < 15
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
| The Relationship Between the Residual Renal Function and Osteoporosis Treatment | NCT02304887 | Entailment |
6,270 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Pneumonia confirmed by CT scans
Exclusion Criteria:
- a history of chronic renal failure;
- a history of kidney transplantation;
- intake of substances with a history of renal toxicity (no later than a month before
inclusion);
... | Kidney Injury Severity and COVID-19 | NCT04386564 | Contradiction |
689 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Age ≥ 18 < 75 years
- Ferritin > 250 ng/ml and/or stainable iron at biopsy
- NAS ≥ 2 and/or NAS 1 and stage≥1 at liver histology
- Willingness to maintain diet and exercise during the full course of the study
- Written informed consent to... | Effect of Iron Depletion by Phlebotomy Plus Lifestyle Changes vs. Lifestyle Changes Alone on Liver Damage in Patients With Nonalcoholic Fatty Liver Disease With Increased Iron Stores | NCT00658164 | Entailment |
2,200 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
1. Adult men or women ≥18 years of age.
2. Uncontrolled gout, defined as meeting the following criteria:
- Hyperuricemia during the screening period defined as sUA ≥6 mg/dL
- Failure to maintain normalization of sUA with xanthine oxidase inhibi... | Infusion Duration Study To Assess Tolerability of Pegloticase Administered With a Shorter Infusion Duration in Subjects With Uncontrolled Gout Receiving Methotrexate | NCT04511702 | Contradiction |
5,268 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria
Patients must meet all of the following inclusion criteria below to be included as research
subjects:
1. The patient is at least 50 years of age
2. The patient has a score on the back pain visual analog scale (VAS) of ≥70 mm after 2
to 6 weeks of co... | The Kiva® System as a Vertebral Augmentation Treatment | NCT01123512 | Entailment |
2,403 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Patients undergoing a muscle biopsy for IRB11-00203.
Male
No healthy subjects accepted to join the trial.
| Sedation During Muscle Biopsy in Patients With Duchenne Muscular Dystrophy | NCT01645098 | Entailment |
1,739 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- The subject is male or female, aged ≥18 and <50.
- The subject is in good general health with no evidence of any medical problems.
- The subject has both wrist circumferences between 14 and 22cm.
- The subject has provided informed consent and is wil... | Accuracy of ScanWatch Pulse Oximeter With Profound Hypoxia | NCT04380389 | Entailment |
3,159 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Be at least 18 years of age;
- Provide written informed consent;
- Have a reported history of dry eye;
- Have a history of use of eye drops for dry eye symptoms;
Additionally for Part 2
Symptoms of dry eye syndrome including:
... | Safety and Efficacy of TOP1630 for Dry Eye Syndrome | NCT03088605 | Contradiction |
867 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Males or Females between the ages of 40-75 with a diagnosis of moderate to severe
osteoarthritis of the knee, consistent with the American College of Rheumatology (ACR)
Clinical Classification Criteria for Arthritis of the Knee:
- Current knee... | A Four-Arm Study Comparing the Analgesic Efficacy and Safety of Tramadol Once a Day 100, 200 and 300 mg Versus Placebo for the Treatment of Pain Due to Osteoarthritis of the Knee | NCT00832416 | Entailment |
5,194 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Three or more years after menopause
- Bone mineral density T-score < or = -2.0 by dual-energy x-ray absorptiometry (DXA) of
vertebrae or femoral neck, or by quantitative computerized tomography (QCT) of
vertebral body trabeculae
Exclusion ... | Parathyroid Hormone (PTH) for Osteoporosis in Postmenopausal Women | NCT00086619 | Entailment |
1,942 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Control group
- those who were between 25 and 80 years old and did not have any evidence of
gastric cancer and gastric dysplasia, esophageal tumor and MALToma in upper
gastrointestinal endoscopy
- Gastric cancer group
... | OLGA and OLGIM Stage System for Gastric Cancer | NCT03380052 | Entailment |
489 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Females with history of recurrent pregnancy loss
- for control group healthy females with history of at least one uncomplicated full
pregnancy.
Exclusion Criteria:
- no history of endocrinal disorders
- no history of immunologic... | JZ Thickness as a Predictor of Recurrent Unexplained First Trimesteric Pregnancy Loss. | NCT03054558 | Contradiction |
1,505 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- referral by a physician for swallowing evaluation because of suspected dysphagia
- complaint of difficulty swallowing
- aspiration or penetration of the laryngeal vestibule with liquids or semisolids OR
post-swallow residue visible in the oral cavit... | Study of Tongue Strengthening for Swallowing Problems | NCT01570023 | Entailment |
6,674 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Main Inclusion Criteria:
- Participant and/or legal representative has/have voluntarily provided signed informed
consent
- Participant is 12 to 65 years old at the time of screening
- Participant is male with severe hemophilia A (Factor VIII (FVIII) clotting activity <
... | Study Investigating a PEGylated Recombinant Factor VIII (BAX 855) for Hemophilia A (PROLONG-ATE Study) | NCT01736475 | Contradiction |
2,900 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Able to provide informed consent.
- Diagnosis of clinically definite ALS, clinically probable-laboratory supported ALS,
clinically probable ALS, or clinically possible ALS based on the revised El Escorial
criteria.
- Patients with ALS ≤... | A Study to Explore the Safety and Tolerability of Acthar in Patients With Amyotrophic Lateral Sclerosis | NCT01906658 | Entailment |
5,377 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
1. Female subject, between the years 18-30, at the time of consent.
2. Subject is willing to participate and is capable of giving informed consent. (Note:
Consent must be obtained prior to any study-related procedures.)
3. Subject must be willing to comp... | Alternating Urine Redox Status Of Consecutive Menstrual Cycles | NCT04157309 | Entailment |
4,545 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- The inclusion criteria for RIF group were: unexplained repeated implantation failure
(RIF) is defined as the absence of a gestational sac on ultrasound at 5 or more weeks
after embryo transfer (ET) after 3 embryo transfers with high quality embryos or after
... | Transcriptomic Profile of Endometrium in Different Histological Dating of Hormone Replacement Cycle | NCT03222882 | Contradiction |
1,897 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Age between 18 to 75 years old
- Primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or
poorly differentiated) confirmed pathologically by endoscopic biopsy
- Locally advanced tumor in the upper third or middle third of s... | Robotic Total Gastrectomy for Locally Advanced Proximal Gastric Cancer | NCT03524287 | Entailment |
4,153 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com
Inclusion Criteria:
- Healthy male subjects as determined by no clinically significant deviation from normal
in medical history, physical examination, ECGs, and clinical labora... | Absorption, Distribution, Metabolism and Excretion (ADME) Study of BMS-986020 | NCT02068053 | Contradiction |
5,366 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women diagnosed with Idiopathic Menorrhagia and Mirena inserted for a period no longer
than three months according to the assessment of the investigator and according to the
international and national guidelines. These women should also accept to be on
... | Survey on Patient Satisfaction Rate for Mirena Use in Heavy Menstrual Bleeding | NCT00874653 | Contradiction |
5,287 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. Patient is at least 50 years old.
2. Patient must have a fracture due to diagnosed or presumed underlying primary or
secondary osteoporosis (Patients with AO type A1 fractures (all) may be included in
the study).
3. Patient must have conf... | Clinical Evaluation of the Crosstrees Pod™ in the Treatment of Pathologic Fracture of the Vertebral Body (Levels T4 - L5) in Adult Patients | NCT00933036 | Entailment |
2,835 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Age 18 through 80 years inclusive;
2. Geographically accessible to the site and able to come to the site once a week for 24
weeks;
3. Definite, probable, probable laboratory supported ALS diagnosis according to the
revised El Escorial cri... | The Effect of RNS60 on ALS Biomarkers | NCT03456882 | Entailment |
339 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Singleton pregnancy.
- 14-24 weeks gestation..
- Missed miscarriage
Exclusion Criteria:
- History of pulmonary, hepatic, renal, or cardiovascular diseases.
- History of previous cesarean section and other uterine surgeries as hys... | Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester Abortion | NCT02694198 | Contradiction |
4,900 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Clinical diagnosis of Parkinson's Disease (PD)
- Healthy
Exclusion Criteria:
- Subject does not have clinical diagnosis of PD, however, has another neurological
disorder/disease that manifests with symptoms of tremor or dysphonia
... | A Study to Analyze Symptoms Prevalent in Early PD (Dysphonia, Tremor) | NCT04288804 | Contradiction |
6,809 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients diagnosed with hemophilia A or B.
- Patients over 18 years of age.
Exclusion Criteria:
- Patients with neurological or cognitive impairments that hinder oral and written
comprehension.
- Patients who have not signed the... | Development of a Specific Measure for Assessing Adherence in Adult Patients With Hemophilia. | NCT02197611 | Entailment |
640 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Male individuals aged between 18 and 40 years old
- Body mass index (BMI) between 18 and 25
- Normal at clinical examination
- Normal biological variables
- Written informed consent
Exclusion Criteria:
- Mutation C282... | Study of the Effects of Muscular Activity on Iron Metabolism | NCT00378469 | Contradiction |
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