id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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1,137 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- patient with newly diagnosed hypertrophic cardiomyopathy (HCM), based on conventional
echocardiographic criteria.The diagnosis of HCM will be considered definite in the
presence of left ventricle hypertrophy without cavity dilatation and without other
... | New Diagnostic Strategy in Hypertrophic Cardiomyopathy | NCT02520856 | Entailment |
2,146 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Age ≥ 18 to < 70 years
- Baseline sUA ≥ 6.0 mg/dL after at least 2 weeks of treatment on a stable 300 mg dose
of allopurinol
- Documented diagnosis of gout according to the American Rheumatism Association
--Preliminary Criteria for the ... | Study to Evaluate sUA Lowering Activity, Safety and Efficacy of Oral Ulodesine Added to Allopurinol | NCT01265264 | Contradiction |
235 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Unexplained infertility
Exclusion Criteria:
- Known allergy to FSH
- Diabetes, hypertension, known cardiac, renal or liver disease.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 ... | Stimulated Intrauterine Insemination Cycles and Unstimulated Intrauterine Insemination Cycles in Couples With Unexplained Infertility | NCT02461173 | Contradiction |
4,465 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
1. Diagnosis was refractory tennis elbow;
2. Standard extracapsular method was used for surgery.
Exclusion Criteria:
1. Patient had past history of joint infection, joint tuberculosis, or osteomyelitis, or
the upper limb had undergone surgery wi... | Extracapsular Arthroscopic Treatment for Refractory Tennis Elbow--Mid-and-short Term Retrospective Study of 50 Cases | NCT04454047 | Contradiction |
1,727 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Healthy male volunteers between 18 and <46 years of age.
2. Subjects who provide written informed consent to participate in the study.
3. BMI ranging from 18.0 to <30.0, calculated as Weight (Kg)/Height (m2).
4. Non-smoking (by declaration) for a period... | Safety and Pharmacokinetics of Phaffia Rhodozyma Astaxanthin | NCT03807050 | Entailment |
534 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Healthy women ages 18 - 45 years.
- Regular menstrual cycles (24-35 days).
- Pelvic pain ≥ 3 months with cyclical component.
- Negative pregnancy test and must use nonhormonal contraception.
- Non-lactating.
- No history of li... | Use of Rosiglitazone in the Treatment of Endometriosis | NCT00115661 | Contradiction |
453 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Diagnosis of infertility who are candidate for IVF
2. Surgical diagnosis of endometriosis within 10 years of study entry
3. Willing to sign/give informed consent and adhere to parameters of study
4. Normal endometrial cavity as diagnosed by 3D ultrasoun... | Comparison Elagolix vs Depot Leuprolide Prior to Frozen Embryo Transfers in Patients With Endometriosis | NCT04445025 | Contradiction |
5,177 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Post-menopausal women aged 50-80 years
- T score < -2.5 at lumbar spine, total hip or femoral neck on dual x-ray absorptiometry
(DXA) OR T score < -1.5 with a personal or family history of fracture
Exclusion Criteria:
- Previous use of bisp... | Stem Cell Recruitment in Osteoporosis Therapy | NCT01656629 | Entailment |
4,028 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients with knee osteoarthritis grade II or III of the Kellgren-Lawrence
radiographic scale
- Age > 30 years
Exclusion Criteria:
- Neurodegenerative, autoimmune, genetic or psychiatric diseases
- Active infection
- ... | Autologous Stem Cells in Osteoarthritis | NCT01485198 | Entailment |
1,418 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Greater than or equal to 65 years of age
- Primary hypercholesterolemia
- Combined dyslipidemia
- Completed study NK-104-306 (NCT00257686)
Exclusion Criteria:
- Failed to complete study NK-104-306(NCT00257686)
No condition on gen... | Study of Pitavastatin in Elderly Patients With Primary Hypercholesterolemia or Combined Dyslipidemia | NCT00330876 | Contradiction |
153 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male, age 18-75
- Morning serum testosterone (T) <300 ng/dL on two occasions
- Naive to androgen-replacement therapy or willing to wash-out from current T therapy
Exclusion Criteria:
- Significant intercurrent disease
- Abnormal ... | Pharmacokinetic Study to Determine Time to Steady-state | NCT00911586 | Entailment |
6,703 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. The subject is male or female, aged ≥18 and <50.
2. The subject is in good general health with no evidence of any medical problems.
3. The subject is fluent in both written and spoken English.
4. The subject has provided informed consent and is willing ... | Accuracy of Pulse Oximeters With Profound Hypoxia | NCT02571686 | Contradiction |
392 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- 4- Poor responder according to ESHRE consensus; in which at least 2 of the following
should be present: Advanced maternal age (≥ 40 years old) or any other risk factor A
previous poor ovarian response (cycles cancelled or ≤ 3 oocytes with a conventional
... | The Impact of Body Weight on Reproductive Outcomes in Poor Ovarian Responders in ICSI Cycles | NCT03457233 | Contradiction |
2,934 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Aged 18 to 80 years old, inclusive, on Day 1.
- Diagnosis of sporadic or familial ALS.
- Onset of first ALS symptoms within 24 months prior to Day 1.
- World Federation of Neurology El Escorial criteria are met for a possible,
laboratory... | Phase 3 Study of Dexpramipexole in ALS | NCT01281189 | Entailment |
6,677 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male and female patients of any age and ethnicity
- Severe haemophilia A (FVIII:C<1%)
- Decision to prescribe Octapharma's FVIII concentrate before enrollment into the study
- Either
- No previous treatment with FVIII concentrates or othe... | Efficacy, Safety & Utilisation of Nuwiq, Octanate and Wilate in Previously Untreated & Minimally Treated Haemophilia A Patients | NCT03695978 | Contradiction |
4,363 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Must be between the ages of 12-21
- Diagnosis of Marfan Syndrome
- Must not have other conditions that limit the patients ability to perform exercise
Exclusion Criteria:
- Patients who have undergone aortic surgery
- Patients wit... | Marfan Syndrome Moderate Exercise Pilot | NCT04641325 | Entailment |
19 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria
- Medically stable, ambulatory, surgically menopausal women, 21-60 years of age, who
have undergone bilateral salpingo-oophorectomy and hysterectomy at least 6 months
before study entry
- Serum total testosterone concentrations less than 31 ng/dL or f... | Testosterone Dose Response in Surgically Menopausal Women | NCT00494208 | Contradiction |
3,007 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Clinical diagnosis of intellectual disability
- Age 16 or older and providing consent to participate.
Exclusion Criteria:
-
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.
| North Health in Intellectual Disability | NCT03889002 | Contradiction |
380 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women undergoing ICSI with expected poor ovarian response according to the Bologna
criteria
Exclusion Criteria:
- Body mass index >35 Kg/m2.
- Women with a single ovary.
- Allergy to DHEA or GH.
- Diabetic women on i... | Combined Dehydropeiandrosterone and Growth Hormone in Women With Expected Poor Ovarian Response Undergoing ICSI | NCT02766764 | Contradiction |
5,896 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Subject who has signed on the written consent
2. Male and female aged 20 and over
3. Endoscopically verified Reflux Esophagitis classified into Los Angeles classification
Grade A, B, C or D within 2 weeks before randomisation
Exclusion Criter... | Study to Investigate the Safety, Tolerability and Efficacy of YH4808 in Patients With Reflux Esophagitis | NCT01538849 | Contradiction |
2,269 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Being between the ages of 9-14
- Being literate in Turkish
- Not having any physical disability preventing them from doing physical activities
- Attending physical education class regularly
Exclusion Criteria:
- Having a serious ... | Encouraging Physical Activity: Action Or Direction? | NCT04300634 | Contradiction |
3,764 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients ≥40 and ≤ 75 years of age
- For a woman, she should meet one of the following criteria to be eligible for the
study: i) A woman of no childbearing potential ii) As for a woman of childbearing
potential, she should have a negative pregnancy... | Efficacy and Safety Study of PG201 Tablet in Patients With Osteoarthritis | NCT01122485 | Entailment |
3,205 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- they fulfill the new American-European Consensus Group criteria for pSS and have :
- a recent (less than 10 years) and active disease as assessed by :
- values > 50 mm on 2 of 4 visual analogue scales (VAS) (0-100mm) that evaluated global
scores of ... | Tolerance and Efficacy of Rituximab in Sjogren's Disease | NCT00740948 | Entailment |
3,241 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | INCLUSION CRITERIA
Documented primary or secondary SS.
Absence of confounding health problems.
No contraindications to etanercept therapy.
SS patients cannot have sarcoidosis, HIV infection, or lymphoma.
Patients must have one of the following abnormal autoimmune serologies ... | Etanercept Therapy for Sjogren's Syndrome | NCT00001954 | Entailment |
3,851 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Pain in the knee joint during more than a half day assessed by VAS (score more than 40
mm)
- At least three of the following 6 criteria: 50 years of age or older, stiffness
lasting less than 30 minutes, crepitus, bony tenderness, bony enlargement, ... | Effectiveness and Safety of Autologous ADRC for Treatment of Degenerative Damage of Knee Articular Cartilage | NCT02219113 | Entailment |
3,046 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Documentation of a full mutation with absence or deficient FMRP levels.
- Males and females ages 10 through 17 years
- Willingness of potential study participant as well as a parent or caretaker to
participate in the protocol.
- Speech i... | Combining Lovastatin and a Parent-Implemented Language Intervention for Fragile X Syndrome | NCT02642653 | Entailment |
1,345 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Parent(s) or guardian(s) willing and able to provide signed informed consent after the
nature of the study has been explained and prior to performance of any
research-related procedure. Also, willing and able to provide written assent (as
needed) ... | A Multicenter, Multinational Clinical Assessment Study for Pediatric Patients With Achondroplasia | NCT01603095 | Entailment |
3,963 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
Inclusion Criteria for OA patients:
- Fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of
knee osteoarthritis
- Symptomatic knee pain
- On usual care for knee osteoarthritis including paracetamol and/or NSAIDs
... | Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis | NCT03533569 | Entailment |
2,482 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | INCLUSION CRITERIA:
Men and women aged 60 years or older.
Patients ranging from no AMD with little or no drusen in either eye through end stage AMD
(geographic atrophic, retinal pigment epithelial detachment, or other signs of
neovascular/exudative disease) in their eye with worst dise... | Lutein for Age-Related Macular Degeneration | NCT00006202 | Entailment |
4,006 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Subjects were 18 years or older
- Subjects had osteoarthritis (OA) defined by:
Presence of of typical hip and/or knee joint symptoms. Involvement of at least 1 hip or
knee joints that had warranted treatment with Non-Steroidal Anti-Inflammatory Drugs
... | A Safety, Tolerability and Pharmacokinetic Dose Escalation Study of HC-ER in Patients With Osteoarthritis Pain | NCT02222740 | Entailment |
1,866 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- The patient from over 20 to under 90 years
- The patient who is diagnosed as gastric cancer clinically by endoscopy or computed
tomography
- The patient who is informed and consent about the purpose and contents of this study
prior to t... | NBI for Identifying Resection Margin Status in Gastric Cancer | NCT02926716 | Entailment |
5,883 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Participants diagnosed with reflux esophagitis of Grade A or higher by Los Angeles
(LA) classification based on the endoscopy among participants complaining of
gastroesophageal reflux symptoms (such as: Heartburn, regurgitation, globus sensation,
... | An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis | NCT01008696 | Contradiction |
5,335 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Patients of both sexes, of any race, aged over 12 years.
- Ability to read, understand and sign the IC, in the case of minors consent of
responsible;
- Clinical diagnosis of bruises, sprains, trauma, muscle damage occurred in less than 24
... | To Evaluate the Efficacy and Safety Aliviador Compared to Gelol in Patients With Contusions, Sprains, Trauma and Muscle Injury. | NCT01097798 | Contradiction |
4,816 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Cushing's disease of endogenous origin: Who have failed surgery (or) who are awaiting
surgery (or) for whom surgery is not an immediate option.
- The diagnosis of Cushing's disease must be confirmed by each of the following:
- The clinical crit... | Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in Pediatric Patients With Cushing's Disease | NCT03708900 | Contradiction |
3,543 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- age > 18 years
- chronic adrenal failure with disease duration > 12 months and hormone replacement
therapy for cortisol deficiency
Exclusion Criteria:
- adrenal insufficiency due to adrenocortical carcinoma
- AI due to long-term... | Survey in Patients With Chronic Adrenal Insufficiency in Germany | NCT00444119 | Entailment |
1,612 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Part 1: 1.Must understand and voluntarily sign a written Informed Consent prior to any
study-related procedures being performed.
2.Must be able to communicate with the Investigator, understand and comply with the
requirements of the study, and ag... | Food Effect and CYP1A2 Induction Study in Healthy Subjects | NCT02168205 | Contradiction |
3,288 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- Healthy term, gestational age of 38-42 weeks inclusive.
- Able to be transported to the Eye Clinic.
- No longer monitored. On no intravenous or other lines.
Exclusion Criteria:
- History of hyperglycemia in the infant (a blood sugar greater ... | Spectral Domain Optical Coherence Tomography Imaging of the Eyes of Neonates | NCT01404247 | Contradiction |
3,966 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Male or female, 18 years of age and older.
- Participants must meet American College of Rheumatology (ACR) criteria for
osteoarthritis of the knee (unilateral or bilateral). Clinical criteria includes knee
pain and at least three of the following 6... | A Prospective Study Evaluating the Treatment of Knee Osteoarthritis With the Cryo-Touch III Device | NCT01704157 | Entailment |
5,752 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Symptomatic lesions.
- OLP lesions with the diagnosis confirmed both clinically and histopathologically.
- Clinical score higher than 3.
- Disease duration of more than 2 months.
- Absence of dysplasia in histological section
Exc... | Efficacy of Green Tea Buccal Tablets in Oral Lichen Planus | NCT03415165 | Contradiction |
1,722 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Age 18-45 years, inclusive, of both genders
- Negative pregnancy test for females who are not s/p hysterectomy with oophorectomy
- No history of episodic wheezing, chest tightness, or shortness of breath consistent
with asthma, or physician-diagnose... | Woodsmoke Particulate + Prednisone | NCT03861390 | Entailment |
3,754 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
Patients eligible for the study were:
- older than 50 years and
- had primary knee OA diagnosed according to the clinical and radiological criteria of
the American Rheumatism Association.
Further inclusion criteria were:
- clinical s... | NSAID Treatment in Knee Osteoarthritis | NCT01860833 | Contradiction |
625 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Age > 18 years
- Admission to the general cardiology or heart failure services and under the care of a
cardiologist at the study institution
- New York Heart Association Class II-IV heart failure
- Ejection fraction < 40%
- S... | Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure | NCT01925703 | Contradiction |
354 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- women in good general health with regular, ovulatory menstrual cycles
- age 18-35
- not pregnant
- not sexually active or reliably use barrier methods of contraception
- normal liver and renal functions and normal laboratory exams
... | Low Dose Continuous Administration of the Progesterone Receptor Modulator VA2914 | NCT00456924 | Contradiction |
6,908 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Age: 70-85 years old
- Presence of memory impairment
- Completed educational level: middle school
- Visual and auditory acuity: normal or corrected-to-normal
Exclusion Criteria:
- Monogenic AD
- Presence of a neurolog... | Neuroelectrical Biomarkers for Alzheimer's Disease Stages | NCT01880151 | Entailment |
2,399 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Diagnosis of DMD or Becker muscular dystrophy with confirmed dystrophin nonsense mutation.
Measurable limb or pulmonary weakness.
Signed consent.
Must not have a history of hypersensitivity reaction to an aminoglycoside.
Must not have abnormal baseline hearing.
Must not have... | Gentamicin Treatment of Muscular Dystrophy | NCT00005574 | Entailment |
5,139 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Present with osteoporosis based on total hip, femoral neck or lumbar spine BMD T-score
of less than or equal to -2.5 but must never have had any osteoporotic fragility
fracture.
- Are ambulatory and are 60 to 85 years of age, inclusive. Aside from ... | A Study of Arzoxifene to Treat Korean Women With Osteoporosis | NCT00767299 | Contradiction |
875 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Age ≥ 18 years.
2. Informed consent obtained.
3. Patients with hand OA as defined by the American College of Rheumatology
Classification Criteria for hand OA:
- Hand pain, aching or stiffness
And 3 or 4 of the following featu... | Diagnostic Accuracy of Dual-energy CT | NCT04585113 | Entailment |
3,490 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- All adults above the age of 18 presented to the Assiut university Clinic with
cholesteatoma will be included in the study.
Exclusion Criteria:
1. Patients with previous mastoid surgery
2. Patients with Craniofacial anomalies or cleft lip and pala... | Level of Middle Cranial Fossa Dura in Patients With Cholesteatoma | NCT04551612 | Entailment |
1,097 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
1. All patients that present with hypertrophic obstructive cardiomyopathy (HOCM) with
mean pressure gradient>50 mm Hg at rest or on provocation
2. HOCM patients with severe mitral regurgitation.
3. HOCM patients with New York Heart Association (NYHA) fun... | Hyp Obst Cardiomyopathy | NCT04329689 | Entailment |
2,049 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Healthy volunteers
- Volunteers with active Pneumothorax, detected by prior imaging studies up to 24 hours
before the ultrasound scan
- Volunteers with active Pleural effusion, detected by prior imaging studies up to 48
hours before the... | Diagnosis and Classification of Pleural Diseases Using Ultrasound Channel Data | NCT04418804 | Contradiction |
3,527 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Written informed consent.
- Patients with adrenal diseases.
- A diagnostic computed tomography (CT) or magnetic resonance imaging (MRI) of the
adrenal region within the previous 6 months prior to dosing day is available
Exclusion Criteria:
... | Gallium-68 Labeled Pentixafor PET/CT in Adrenal Masses | NCT04859959 | Entailment |
6,652 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | - Males with severe hemophilia B with Factor IX activity level < 1% of normal.
- Life expectancy of > 1 year.
- Age > 18 years old.
- Ability to give informed consent.
- Greater than twenty exposure days of treatment with Factor IX protein.
- No history or pr... | Safety of a New Type of Treatment Called Gene Transfer for the Treatment of Severe Hemophilia B | NCT00076557 | Contradiction |
5,638 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Diagnosis of Turner syndrome
- Less than the 50th percentile for length for the general female population
Exclusion Criteria:
- Prior Growth Hormone (GH) therapy
- Diabetes
- Allergy to metacresol (a preservative in the GH liquid... | Effect of Growth Hormone on Early Brain Development in Girls With Turner Syndrome | NCT01367834 | Contradiction |
2,914 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Lab supported probable or more definite ALS by El Escorial Criteria
2. Age greater than or equal to 18 years
3. Willing and able to provide informed consent
4. On riluzole at a stable dose for at least 30d or not taking this
5. On Radicava at... | A Pilot Trial of Triheptanoin for People With Amyotrophic Lateral Sclerosis (PALS) | NCT03506425 | Entailment |
5,862 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- persons undergoing wireless pH testing for diagnosis and treatment of GERD
Exclusion Criteria:
- those under the age of 18
- pregnant and lactating women
- those who do not meet the inclusion criteria
No condition on gender to be admitted to... | Effect of Coffee on Gastro-Esophageal Disease in Patients With Symptoms of Reflux | NCT00584259 | Contradiction |
1,823 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. 18 years ~ 75 years;
2. the primary adenocarcinoma (papillary adenocarcinoma, tubular adenocarcinoma, mucinous
adenocarcinoma, signet ring cell carcinoma, poorly differentiated adenocarcinoma);
3. clinical stage T2-4a, N0-3, M0 (according to AJCC-7th ... | A Multicenter Clinical Trial on Laparoscopic Gastric Cancer Surgery Compared With Open Surgery | NCT02302794 | Entailment |
2,626 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- 6 to 16 year old patients of both gender
- ASA (American Society of Anesthesiologists) I and ASA II patients
- Scheduled for elective lower abdominal surgery (inguinal hernia repair or
circumcision) or orthopedic surgery (upper and lower limb) under... | Postoperative Sore Throat in Children: Comparison Between Two Supraglottic Devices, Ambu® AuraOnce™ Laryngeal Mask Airway (LMA) and I-Gel®. | NCT03140228 | Contradiction |
76 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Men >18 years of age
- Diagnosis of an incomplete SCI involving spinal segments T12 or above, for >12-months
- Low serum total testosterone (<300 ng/dL), bioavailable testosterone (<75 ng/dL), or
free testosterone (<64 ng/dL)
- Presence ... | Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury | NCT04460872 | Contradiction |
6,347 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Inclusion criteria :
- Adult aged 18 to 75 years old
- Taken into primary health care for suspicion of early-stage COVID-19 infection
(maximum 5 days of evolution). The patient must have presented within the previous 5
days at least one... | Efficacy of Azithromycin-associated Hydroxychloroquine Therapy Given in General Practice in Early-stage Disease in COVID-19 Patients | NCT04371406 | Entailment |
5,729 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- BMI 19-27 kg/m2
- smokes >10 cigarettes per day for preceeding 6 months
Exclusion Criteria:
- inability to stop smoking during study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Su... | A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers | NCT01702519 | Contradiction |
2,045 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- confirmed diagnosis of stomach cancer
- advanced stomach cancer stage IV
- adequate blood chemistry, blood counts and kidney function
- willing to participate to study requirements and to sign an informed consent document
Exclusion Criteria:... | Study Of Sunitinib In Combination With Cisplatin And 5-Fluorouracil In Patients With Advanced Gastric Cancer | NCT00555672 | Entailment |
1,220 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Age >18 years Presence of undiagnosed exudative pleural effusion as determined by the
criteria detailed by Light et al where a specific diagnosis was not obtained after
initial cytological and/or microbiological examinations.
Adequate rib spaces for s... | Mini Thoracoscopy vs Semirigid Thoracoscopy in Exudative Pleural Effusions | NCT02851927 | Entailment |
5,223 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Clinical diagnosis of Osteoporosis
- Must be able to swallow tablets
Exclusion Criteria:
- N/A
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
| The Effectiveness of Eldecalcitol in the Bisphosphonate Non-respondered-patients With Osteoporosis | NCT02306187 | Entailment |
6,737 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients with diagnosis of hemophilia A, independent of age, treated with KOGENATE® FS
as their only source of FVIII, decision taken by the investigator to administer
KOGENATE® FS. For pretreated patients with more than 100 exposure days an inhibitor
... | Effekt-2 - Efficacy and Safety of Long-term Treatment With KOGENATE® FS in Latin America | NCT00969319 | Contradiction |
827 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Knee pain and crepitus with active motion and morning stiffness ≤ 30 min ages ≥ 38 and
≤ 80
2. Knee pain and crepitus with active motion and morning stiffness >30 minutes and boney
enlargement ages ≥ 38 and ≤ 80
3. Knee pain and no crepit... | Comparing Manipulation, Rehabilitation and Combination of the Two in the Treatment of Knee Osteoarthritis | NCT01188837 | Entailment |
1,873 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Histologically proven gastric adenocarcinoma
2. ≥ D2 resection
3. Stage IB(T1N1,T2bN0), II, IIIA, IIIB, IV(T4,N3 포함, M1 lymph node 제외)
4. 18 ≤ age ≤ 75
5. ECOG 0-2
6. No distant metastasis
7. Adequate bone marrow functio... | Phase III Randomized Trial of Adjuvant XP Chemotherapy and XP/RT for Resected Gastric Adenocarcinoma | NCT00323830 | Entailment |
2,530 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Children with atopic eczema according to Hanifin and Rajkas criteria with a mother
breastfeeding the child or a sibling.
- The eczema spots in the treatment and control areas were to be similar in features and
extent as well as being localized on c... | Topical Treatment With Fresh Human Milk Versus Emollient on Atopic Eczema Spots in Young Children | NCT02381028 | Entailment |
4,175 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
General and Demographic Criteria
- Age of 18 to 40 years
- Access to a participating HVTN clinical research site (CRS) and willingness to be
followed for the planned duration of the study
- Ability and willingness to provide informed consent
... | Evaluating the Safety and Immunogenicity of HIV Clade C DNA Vaccine and MF59- or AS01B-Adjuvanted Clade C Env Protein Vaccines in Various Combinations in Healthy, HIV-Uninfected Adults | NCT02915016 | Contradiction |
3,553 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Age > 18 years
- patient's written informed consent
- Ability to comply with the protocol procedures
- patients with primary or secondary adrenal insufficiency under established stable
replacement therapy
No condition on gender to be adm... | National Education Programme for Patients With Chronic Adrenal Insufficiency | NCT02694926 | Entailment |
2,096 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- IPF, diagnosed according to the American Thoracic Society (ATS) and European
Respiratory Society (ERS) consensus statement (with or without surgical lung biopsy)
- Pulmonary hypertension, defined as mean pulmonary artery pressure (MPAP) greater than
... | Sildenafil to Increase Exercise Capacity in Individuals With Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension | NCT00352482 | Entailment |
6,025 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Age older than 20 years
- Initially suffering from large hiatal hernia (>20% of the stomach in the thoracic
cavity)
- Performance of laparoscopic hiatal hernia repair
- Informed Consent as documented by signature
Exclusion Crite... | Approach to Hiatal Hernia Repair Based on Collagen Study | NCT04152798 | Entailment |
3,419 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | - INCLUSION CRITERIA:
In order to be eligible to participate in this study as a subject with HI, an individual
must meet all of the following criteria:
1. Provision of signed and dated informed consent.
2. Stated willingness to comply with all study procedures and availability fo... | Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets | NCT04806282 | Entailment |
5,292 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- seek primary care (GP, physiotherapist or chiropractor)
- new episode of back pain
- no visit of primary care the preceding 6 months for back pain
Exclusion Criteria:
- cognitive impairments
- difficulties speaking and writing No... | BACk Pain in Elders in Norway (BACE-N) | NCT04261309 | Entailment |
4,275 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria
1. Subjects ≥ 6 years of age at time of Informed Consent Form (ICF) or Assent Form
signing.
2. Confirmed diagnosis of CF, determined by having clinical features consistent with the
CF phenotype, plus one of the following:
1. Positive swe... | A Study of AeroVanc for the Treatment of MRSA Infection in CF Patients | NCT03181932 | Entailment |
4,346 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | INCLUSION CRITERIA:
Individuals and their family members will be offered enrollment if they have a suspected or
established diagnosis of Marfan, Stickler, Ehlers-Danlos, or a closely related syndrome.
Personal or family history of one or more of the following features in a pattern suggestive
... | Study of Heritable Connective Tissue Disorders | NCT00001641 | Entailment |
3,962 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Knee OA symptoms resulting in contact with the health care system
Exclusion criteria (both study groups):
- Another reason than OA for the problems; includes tumour or inflammatory joint disease
- Other symptoms that are more pronounced than the OA symp... | On-line Neuromuscular Exercise and Education for Knee Osteoarthritis | NCT04437134 | Entailment |
4,422 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Clinical diagnosis of Lateral Epicondylitis Disease
- has been doing professional sports for at least three years
Exclusion Criteria:
- Having systemic problems,
- Having health problems,
- Has undergone any surgical operation in... | Investigation of Acute Effect of ESWT and ESWT+KT on Pain and Grip Strength | NCT03763513 | Contradiction |
3,687 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Clinical diagnosis of osteoarthritis of the knee or hip that requires treatment
- American Rheumatism Association (ARA) functional Class I, II or III
- Receiving a stable dose of a traditional non-steroidal anti-inflammatory drug (NSAID),
a Cox-2 se... | A Study of Etoricoxib in Participants With Osteoarthritis Not Responding to Analgesic Drugs (MK-0663-142) | NCT01429168 | Contradiction |
2,108 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Diagnosis of IPF according to international guidelines
Exclusion Criteria:
- Unable to provide written informed consent
- Radiologic, histologic, or clinical findings inconsistent with a diagnosis of IPF
No condition on gender to be admitted to the tria... | Early Diagnosis of Pulmonary Fibrosis - Diagnostic Delay | NCT02772549 | Entailment |
1,266 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Thoracocentesis
- Chest X-ray and
- CT-scanning are performed
Exclusion Criteria:
- Lung cancer
- Other thoracic malignancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subje... | The Added Value of CT Scanning in Patients With an Unilateral Pleural Effusion | NCT03270215 | Entailment |
405 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Infertility
- The length of menstrual cycle longer than 35 days or shorter than/amenorrhea
- Serum FSH levels ≥10mIU/ml/ serum AMH levels ≤1.0pg/ml/ AFC ≤7, on at least two
occasion >4 weeks apart
Exclusion Criteria:
- Polycysti... | Establishing the Diagnosis Standard and Analysis the Risk Factors of POI in Chinese Women | NCT03518918 | Contradiction |
5,667 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | - INCLUSION CRITERIA:
Volunteers will qualify if they meet the following criteria:
1. Age between 12 and 17 years (at the start of the study).
2. Female sex.
3. BMI at or above the 85th percentile for age and sex according to the Centers for
Disease Control US Sta... | Mobile Attention Retraining in Overweight Female Adolescents | NCT02977403 | Contradiction |
837 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Female gender
- Less than 70 years old
- Diagnosis of hand osteoarthritis according to ACR criteria ACR after exclusion of
thumb base osteoarthritis:
1. Hand pain, aching or stiffness most of the days during the preceding month
... | Proteomic Analysis in Sera From Patients With Erosive Hand Osteoarthritis | NCT02370771 | Entailment |
6,402 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Be male or female, ≥18 years of age
- Be willing and able to give informed consent
- Screening/Randomization telemedicine visit within 2 days of testing positive test for
COVID-19
- Having self-reported fever or cough for not more than 7... | A Clinical Study to Assess the Natural History of COVID-19 and Effects of KB109 and Supportive Self-care in Outpatients With Mild-to-moderate COVID-19 | NCT04414124 | Entailment |
2,500 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- No disease that effect the fundus photograph or visual field
Exclusion Criteria:
- any disease that effects the fundus photograph or visual field
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
| A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus Photograph | NCT01843582 | Entailment |
5,940 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- patients between the ages of 15 and 80 years
- with clinical symptoms of acid regurgitation, heart burn, or feeling of acidity in the
stomach,
- who have Los Angeles Grade A and B erosive esophagitis proven by endoscopy are
recruited.
... | Rate of Complete Symptom Relief, Prevention of Symptom Relapse: Grades A and B Esophagitis of Esomeprazole Therapy | NCT01874535 | Contradiction |
4,113 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Symptomatic subjects with moderate to severe COPD
- Age greater than/equal to 40 years
- History of smoking greater than/equal to 20 pack-years of cigarettes
- No history of asthma (in the opinion of the investigator)
- No COPD exacerbati... | Perforomist Versus Foradil Evaluated by Inspiratory Capacity and High Resolution Computed Tomography (HRCT) | NCT00633776 | Contradiction |
6,597 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male patients who are diagnosed with severe (laboratory tested FVIII:C <2%) hemophilia
A;
- Patients Who Completed trial of SCT800-A302 or SCT800-A 303 and New PTP(previously
treated patients)(Previously received FVIII prophylactic or bleeding trea... | Safety and Efficacy of Long-term Treatment With SCT800 in Previously Treated Hemophilia A Patients. | NCT03947567 | Contradiction |
5,535 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- At least 50 years old.
- Suffering from GCA as per investigator judgement, newly diagnosed or not.
- Starting or under treatment for GCA.
- Informed verbally and in writing about this study and not objecting to their data
being electroni... | Assessment of Giant Cell Arteritis Medical Practices in France | NCT03658889 | Entailment |
4,401 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- history of medial and lateral elbow pain for at least three months in duration
- local tenderness for at least three months in duration
- pain on the epicondyle upon active resistive flexion (medial) and extension (lateral)
of the wrist
Exc... | Clinical Trial for High Intensity Laser Therapy (HILT) for Elbow Epicondylosis | NCT01992627 | Contradiction |
462 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Woman older than 18 years
- Patients with gestational trophoblastic disease resistant to mono-chemotherapy
(methotrexate and/or actinomycine-D) or polychemotherapy (such as EMA-CO; EMA-EP; BEP;
… regimens) without . limitation in the number of prev... | Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias | NCT03135769 | Contradiction |
6,446 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- male or females at least 18 years of age
- diagnosis of stable erythematous rosacea
- < 3 inflammatory lesions
- in good general health
- females must be non-pregnant and non-lactating
- must be willing to sign a consent form
... | Dose Response Study of Patients With Erythematous Rosacea | NCT01186068 | Entailment |
5,718 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion criteria :
- girls aged from 1 to 25 years included,
- with Turner syndrome or mosaic
- patients aged more than 18 will only have ovarian insufficiency dated less than 5
years
- without any severe disease, particularly of cardiovascular type
... | Cryopreservation of Ovarian Cortex in Girls With Turner Syndrome | NCT01410045 | Entailment |
4,306 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Clinical diagnosis of cystic fibrosis
- Able to engage in intense physical activities
Exclusion Criteria:
- FEV1 <35%predicted
- Esophageal varicosis
- Pulmonary bullae
- Drop in arterial oxygen saturation with exerci... | Effects of a 6-Months Physical Conditioning Program in Patients With Cystic Fibrosis | NCT00231686 | Entailment |
1,738 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Girl or boy aged ≥ 8 years and ≤ 12 years old for children,
- Girl or boy aged ≥ 13 years and ≤ 19 years old for teenagers,
- Woman or man age ≥ 20 years and ≤ 35 years old for young adults,
- French mother tongue,
- With the right to a s... | Impact of Another Person's Presence on Brain and Behavioral Performance | NCT03453216 | Entailment |
632 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Patients with age equal to or over 18 years old,
- Patients with proved hereditary hemochromatosis with homozygosity for the C282Y
mutation of the HFE gene,
- Patients with rheumatism related to hemochromatosis, considered by the rheumatologist
... | Treatment of Refractory Hemochromatosis Rheumatism by Anakinra: a Preliminary Phase II Study | NCT02263638 | Contradiction |
1,302 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | - INCLUSION CRITERIA:
If a subject meets any one of these criteria, he/she will potentially be eligible to
participate:
- Short stature (height less than - 2 SDS), either currently or previously - or
- Tall stature (height greater than + 2 SDS) or
- Bone age delay (... | Genetic Causes of Growth Disorders | NCT02311322 | Contradiction |
4,752 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | - INCLUSION CRITERIA:
Plus Tinnitus Plus Hearing loss subjects.
- Adults, between the ages of 30 to 65 years.
- Are able to hear and perceive sounds used in the experiment in the range 250 Hz to 2
KHz and have high-frequency sensorineural hearing loss beginning no lower th... | Brain Imaging of Tinnitus | NCT00359931 | Entailment |
4,998 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
1. Men and women age 22 years or older
2. Diagnosis of medication-refractory Essential Tremor
3. Has previously underwent an Exablate index procedure in a clinical trial or in a
commercial setting at least 9 months prior to enrolling in this trial
... | Bilateral Treatment of Medication Refractory Essential Tremor | NCT04112381 | Entailment |
5,649 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Pre-pubertal children (boys age: > 3 and <12 years or girls: age >3 and <11 years)
with isolated GH insufficiency, GH insufficiency as part of multiple pituitary hormone
deficiencies, or organic GH insufficiency. If GH insufficiency occurred after
... | Treatment of Children With Insufficient Secretion of Growth Hormone | NCT00271518 | Contradiction |
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