id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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4,464 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
Subjectswill be included with
- Aged between 18 and 65 years
- Elbow fracture in the six months before the study
- Elbow limitation in flexion or extension
- Being volunteer to participate
- Fractures should be managed with conserv... | The Efficacy of Different Types of Stretching on Range of Motion, Pain and Function in Elbow Limitation | NCT03161782 | Contradiction |
3,661 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- Subjects will be between the ages of 18 and 90.
- Male and female subjects will be recruited into the study.
- All patients will clinically demonstrate unilateral lower extremity pain in greater
proportion to low back pain symptoms if present. Imagi... | Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc | NCT00927056 | Contradiction |
6,043 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Gender：male or female.
2. Age：from 20 years old (inclusive) to 75 years old (inclusive).
3. Diagnosis of gastroesophageal reflux disease.
4. there is a heartburn or acid regurgitation phenomenon.
5. After detailed description of the entire re... | Effective Mechanisms of Wu-Chu-Yu Tang on Gastroesophageal Disorder | NCT04118647 | Entailment |
3,829 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients ≥40 and ≤80 years of age
- Radiographic evidence of grade 1,2 or 3 osteoarthritis based on the Kellgren &
Lawrence radiographic entry criteria
- Stable osteoarthritis during 3 months
- Score of 100mm Pain VAS ≤ 80mm at screening... | To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients of the Knee | NCT02049606 | Entailment |
5,062 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- women age ≥65 years including those using assistive devices to maximize
generalizability if they:
1. Reside in long-term care (LTC);
2. Have:
- osteoporosis by axial bone density (spine, hip or forearm bone mineral
... | Zoledronic Acid for Osteoporotic Fracture Prevention (ZEST II) | NCT02589600 | Contradiction |
4,584 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- women at childbearing age
- age 18-40 years
- BMI 18.5-24.9 kg/m²
- taking oral contraceptives
- not having any contraceptives
Exclusion Criteria:
- chronic and acute infectious diseases
- history of takin... | The Relationship of the Intestinal Microbiome and the Menstrual Cycle | NCT03581201 | Contradiction |
2,384 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | The samples used in this study will be derived from individuals at risk for, or suffering
from, neuromuscular disease, generally resulting in clinical weakness of one or more muscle
groups and their family members.
Inclusion criteria:
1. having a clinical and/or pathological diagnosi... | Molecular Analysis of Patients With Neuromuscular Disease | NCT00390104 | Entailment |
883 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Informed consent obtained.
2. Ambulatory (able to walk unassisted)
3. At least 18 years of age
4. Capable of understanding the study
5. Capable of writing and reading in local language
6. Predominantly tibiofemoral knee osteoarthri... | A 2-year, European Multicentre Study to Describe, Validate, and Predict Phenotypes of Knee Osteoarthritis | NCT03883568 | Entailment |
2,065 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Presenting to the Emergency Department with cough, wheezing and/or dyspnea (shortness
of breath)
- Referred for CXR and/or CT scan
Exclusion Criteria:
- Life threatening medical condition requiring immediate treatment
- Unable t... | Chest Ultrasound of ER Patients With Cough or SOB | NCT02269761 | Entailment |
2,319 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
Subject with Duchenne muscular dystrophy eligible for enrolment in the study must meet all
of the following criteria:
1. Has an out of frame deletion(s) that could be corrected by skipping exon 53 as
confirmed by any of methodology at the time of visit 1. If ... | Exploratory Study of NS-065/NCNP-01 in DMD | NCT02081625 | Entailment |
3,137 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Subject who is the age of older than 19 years at the screeing visit
- Subject who has symptom at least one or more as below for six months(Irritation,
foreign body sensation, burning, mucus discharge, blurring, itching, photophobia,
tired or heavy ... | Phase 2 Clinical Trial to Evaluate the Efficacy and Safety of GLH8NDE in Patients With Dry Eye Disease | NCT04679883 | Contradiction |
261 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
.After electrocision of intrauterine adhesions;
.Or after common gynecologic laparoscopic surgery，patients occurred muscle pain or patients
occurred urinary retention.
Exclusion Criteria:
- Pregnancy;
- Suspected acute inflammation of the ge... | Effect of Pelvic Floor Muscle Electrophysiologic Therapy on Enhanced Recovery After Gynecologic Surgery | NCT03524807 | Contradiction |
4,454 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Age 18 to 64 years
- onset of pain within the past 6 months
- willing to try a steroid injection in the elbow
Exclusion Criteria:
- systemic inflammatory diseases (e.g., rheumatoid arthritis)
- pregnancy
- prior stero... | Corticosteroid Injection for Common Upper Extremity Problems | NCT00438672 | Contradiction |
2,847 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion criteria:
1. Evidence of a personally signed and dated informed consent document indicating that
the patient has been informed of all pertinent aspects of the study. To be additionaly
signed by a delegate signer if the subject is unable to handwrite.
2. Patients... | iPSC-based Drug Repurposing for ALS Medicine (iDReAM) Study | NCT04744532 | Entailment |
5,041 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Bilateral postural tremor with or without kinetic tremor involving hands or forearms,
which is visible and persistent, and long-standing in duration (>5 years). Tremor
involving body parts other than upper limbs may be present, the tremor may be
a... | Motor-related Cortical Potential in Patients With Essential Tremor | NCT01250067 | Entailment |
4,978 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
1. Patients diagnosed with functional movement disorder by a fellowship trained movement
disorders neurologist, presenting predominantly with unilateral or asymmetrical
bilateral involuntary movement in the upper extremity
2. In patients with bilateral... | Mirror Box Therapy as a Treatment Option for Functional Movement Disorders | NCT03660098 | Entailment |
3,969 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients with osteoarthritis (OA) of the hip or the knee (as defined by the American
College of Rheumatology) and radiological evidence of OA from the target joint
- patients must be in need of and waiting for hip or knee replacement
- patients with... | A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, Compared With Placebo in Patients With Osteoarthritis | NCT00236366 | Entailment |
4,214 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Men with primary infertility defined as a state of Azoospermia.
- Men with pathological sperm tests indices as defined by the WHO.
Exclusion Criteria:
- Men with genetic syndromes, and states of Azoospermia secondary to chemotherapy, bone
m... | The Effect of Low Electrical Current on Testicular Spermatocyte Count | NCT02617173 | Contradiction |
5,270 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Age >=50 and one of the below
- New hip fracture in orthopedic ward
- Newly identified radiographic vertebral fractures from plan films in geriatric ward or
clinical vertebral fractures in outpatient clinics
- Newly prescribed with AOMs
... | Fragility Fracture Liaison Service and Anti-osteoporosis Medication Monitoring Service Study | NCT02635022 | Entailment |
399 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Between 18 and 35 years
- BMI ≥ 18 kg/m2
- If ≥ 21 years old, must have had healthy pelvic exam w/in past 2 years
Either:
- Regular menstrual cycles (21-35 days);
- Irregular menstrual cycles (>36 days) with or without a previous... | Ultrasound Characterization of Ovarian Follicle Dynamics in Women With Amenorrhea | NCT01927432 | Contradiction |
2,429 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion criteria
- Patient t referred for specimens by EBUS -TBNA with clinical and radiological
suspicion of sarcoidosis or lymphoma , with pathological lymph node on imaging (small
diameter ≥ 1.0 cm CT-scan or hyper metabolism with PET scan) in para-tracheal
statio... | Effect of Needle Size in Diagnostic Yield of EBUS-TBNA in Sarcoidosis and Lymphoma | NCT03573362 | Contradiction |
737 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Main Inclusion Criteria:
- Male or female patients aged at least 40 years.
- Primary osteoarthritis in a single knee joint, grade II/III based on the Kellgren and
Lawrence classification system.
- Radiographic evidence consistent with osteoarthritis carried out within 6 ... | Osteoarthritis Topical Treatment | NCT01496326 | Contradiction |
770 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Diagnosis of grade I, II or III thumb CMC joint OA in their dominant hand according to
the Eaton Classification Stage
- Pain rating of 4/10 on the Visual Analogue Scale (VAS) during activities of daily
living (ADLs) at the time of the therapy initi... | Proprioceptive Thumb Exercises Program in Patients With Carpometacarpal Joint Osteoarthritis | NCT04738201 | Contradiction |
3,131 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Japanese descent male and female adults who do not have the potential to bear children
>= 50 years of age.
- Determined to be eligible for the study based on medical history, physical
examination, and clinical judgment. Subjects with preexisting st... | Study Evaluating 13-valent Pneumococcal Conjugate Vaccine in Healthy Japanese Adults Aged >= 50 Years | NCT00562354 | Contradiction |
2,837 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Either possible, probable, or definite ALS, predominantly lower motor neuron disease,
predominantly upper motor neuron disease, or bulbar
2. With or without cognitive involvement
3. Willing to participate
4. On no experimental treatment
... | Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone | NCT04097158 | Entailment |
1,093 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- No history of cardiopathy / pneumopathy.
- No history of hypertension or mellitus diabetes.
Exclusion Criteria:
- Pregnancy.
- Athletes.
- Body mass index < 16 or => 30 kg/m2.
- Previous treatment with cardiotoxic che... | Normal Values for Myocardial Left Atrial Strain | NCT03874624 | Contradiction |
677 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Age 18 years of age or older
- Male or female patients homozygous for the C282Y mutation.
- Iron overload as documented by serum ferritin and transferrin saturation
- No known allergy or contraindication to the administration of deferasirox
... | Safety and Efficacy of Deferasirox (ICL670) in Patients With Iron Overload Resulting From Hereditary Hemochromatosis | NCT00395629 | Entailment |
617 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Patients with pregnancy of unknown location (PUL) diagnosed 22 - 27 days after oocyte
retrieval, at first ultrasound routine control (A "pregnancy of unknown location"
(PUL) is a term used to classify a women with a positive pregnancy test and an empty
... | Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology | NCT01589016 | Entailment |
4,895 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Age ≥ 18 years and < 50 years
- Important essential tremor (bilateral postural and/or action tremor since more than
one year)
- Normal physical and neurological examination, except for essential tremor
- Insufficient efficiency of usual ... | Experimental Therapeutics in Essential Tremor Using Transcranial Direct Current Stimulation | NCT01579435 | Contradiction |
1,793 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Aged 18 or above.
- Endoscopically removed colorectal lesion with the following pathological
characteristics:
- A moderately-to-well differentiated adenocarcinoma.
- If possible to judge: distance between adenocarcinoma and ver... | SCar-biopsies After Malignant Colorectal Polypectomy of Uncertain RAdicality | NCT02328664 | Contradiction |
687 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | - INCLUSION CRITERIA
Patients studied under this protocol will be at risk for or have evidence of significant
excess tissue iron.
Most patients will be on regular blood transfusion secondary to either congenital or
acquired anemia.
The majority of patients have homozygous bet... | Deferoxamine for the Treatment of Hemochromatosis | NCT00001203 | Entailment |
1,786 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients must have a histologic diagnosis of adenocarcinoma of the esophagus, GEJ, or
GC based on biopsy material or adequate cytologic exam; tumors of the GC are defined
as originating within 5 cm of the GEJ
- Patients must be clinically staged ac... | FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Chemoradiotherapy in Patients With Esophageal Adenocarcinoma | NCT02037048 | Contradiction |
1,543 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Subject is a white male ≥ 18 and ≤ 45 years of age at the time of screening
- Subject is a nonsmoker for at least 6 months prior to the study start
- Subject has a body mass index ≥ 18 and ≤ 30 kg/m2
- Subject has a clear increase in histamine-induce... | Influence of H1-antihistamines on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin. | NCT04399525 | Contradiction |
5,918 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Clinical diagnosis of non-erosive form of Gastroesophageal Reflux disease
- Dietary fiber deficiency by dietary questionnaire
- pathological gastroesophageal reflux by 24-hours esophageal pH-impedance examination
- willingness to participate (signed ... | Phase IV Study of the Impact of Dietary Fibers on Symptoms and Esophageal Motility in Patients With Non-erosive GERD | NCT01882088 | Contradiction |
1,336 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Girls age 7-18 years
- Normal weight (BMI 5-85%-ile for age) or overweight (>85%-ile)
- With or without signs of excess androgen
- Screening labs within age-appropriate normal range, with the exception of a mildly low
hematocrit (see bel... | Ovarian Contribution to Androgen Production in Adolescent Girls | NCT01421810 | Contradiction |
2,725 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- adult patients presenting with primary unilateral inguinal hernia
- patients planed for a laparoscopic repair
Exclusion Criteria:
- Age below 18 years
- recurrent or incarcerated hernias
- open hernia repair and bilateral hernias... | Laparoscopic Groin Hernia Repair by a 3D ENDOLAP Visible Mesh With or Without LiquiBand Fix 8 Mesh Fixation | NCT02781870 | Entailment |
4,336 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Healthy Japanese men: According to the results of a complete medical history, the
physical examination, vital signs (blood pressure and pulse rate), 12-lead ECG,
clinical laboratory tests
- Age ≥20 and ≤35 years
- Body mass index (BMI) ... | Multiple Rising Inhalative Doses of BI 1744 CL in Healthy Male Volunteers | NCT02172105 | Contradiction |
3,005 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Diagnostic confirmation of full mutation FXS
- 50 ≥ Age ≥18 years. Males and Females included in study.
- General good health as determined by physical exam, medical history and laboratory
work up.
- FXS genetic reports at screening
... | An Initial Study of AZD7325 in Adults With Fragile X Syndrome | NCT03140813 | Contradiction |
5,853 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patients must have had a minimum three-month history of symptomatic GERD, with
heartburn as the predominant symptom, and must report nocturnal heartburn symptoms
(i.e., heartburn symptoms experienced during the night-time period, between 2200 and
... | Open Label Study Evaluating Different Dosing Regimens of Rabeprazole in Gastro-esophageal Reflux Disease (GERD) Patients With Night-time Heartburn Symptoms. | NCT00553449 | Contradiction |
1,503 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
1. Patients aged 20 and older
2. Patients with Dyslipidemia
3. Patients with hypertension
4. Patients who voluntarily signed the consent form.
Exclusion Criteria:
1. Blood Pressure
- In case there is a sitting systolic ... | Efficacy, Safety of Coadministered Pitavastatin and Valsartan in Patients With Hypertension and Dyslipidemia | NCT01402843 | Entailment |
5,556 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- girls between 16 and 18 years
- being classified as being overweight or obese defined with the 85th percentile of body
mass index or above based on the 2007 growth chart for Korean children aged 2-18
years.
- After consultation with a p... | Effects of a 12-week Combined Exercise Program on Ghrelins in Obese Adolescent Girls | NCT04447391 | Contradiction |
5,531 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- diagnosis of a giant intracranial aneurysm
Exclusion Criteria:
- age younger than 18
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Giant Intracranial Aneurysm Registry | NCT02066493 | Entailment |
6,036 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- meets the diagnostic criteria for GERD with a GERD history of frequent episodes of
GERD-related symptoms during the last 2 months prior to study screening. The patient
must also meet the following criteria:
1. The only or main symptom is heartb... | Compound Sodium Alginate Double Action Chewable Tablets 4-hour Esophageal pH Study in GERD Patients | NCT01872897 | Entailment |
4,638 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- American Society of Anesthesiology Classification (ASA) I-II
- 18-45 years
- Regular menstrual cycle
Exclusion Criteria:
- Irregular menstrual cycles
- Patients receiving hormones or drugs affecting the ovulatory cycle
... | Menstrual Cycle on Injection Pain of Rocuronium | NCT02539706 | Entailment |
31 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Men age 18-70
2. Baseline morning Testosterone 150-350 ng/dL x2
3. leutenizing hormone (LH) 1.5-9.2 miU/mL, Follicle stimulation hormone (FSH) 1.6-8.0
miU/mL, Prolactin 4-15 ng/mL
4. Positive Androgen Deficiency in the Aging Male (ADAM) sco... | A Randomized Double Blinded Placebo Controlled Trial Between Anastrozole and Clomiphene to Evaluate Improvement in Hypogonadal Symptoms and Erectile Function Using ADAM, IIEF and EHS Validated Scales | NCT03933618 | Contradiction |
433 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Patients undergoing IVF in an attempt to achieve pregnancy.
- Day 2-4 Follicle Stimulating Hormone (FSH) < 10 IU/ml, LH< 12 IU/ml, and estradiol <50
pg/ml on day 2-4 of menstrual cycle
- Antimullerian Hormone > 1.5
- Between 10 and 20 ba... | Mono-menotropins Versus rFSH Protocol on Embryo Quality | NCT02418533 | Contradiction |
1,162 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Age ≥ 18 years.
- Unilateral pleural effusion of unknown course.
- Patients must be able to give informed consent.
Exclusion Criteria:
- Bilateral pleural effusions.
- Known cause of pleural effusions.
- Life expectan... | Value of Additional Upfront Systematic Lung Ultrasound in the Workup of Patients With Unilateral Pleural Effusion | NCT04235998 | Contradiction |
2,443 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- Patients with confirmed sarcoidosis
Exclusion Criteria:
- (ex-) smokers
- for healthy controls: controls with pulmonary disease excluded
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
| Validation of a Non-invasive Diagnostic Method for Sarcoidosis Using Exhaled Breath | NCT02361281 | Entailment |
2,366 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. One of the following categories:
- Genetic confirmation of spinal muscular atrophy
- Genetic confirmation of Duchenne or Becker muscular dystrophy or evidence on
muscle biopsy with a clinical presentation consistent with DMD/BMD
... | Wearable Technology to Assess Gait Function in SMA and DMD | NCT04193085 | Entailment |
4,220 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Age 18-45 years of either gender
2. Non-smoker (less than 10 cigarettes per month for at least the prior 3 years)
3. Negative pregnancy test (for females as applicable)
4. Oxygen saturation of > 94% and blood pressure with systolic value between 140-90 ... | Study of Airway Inflammatory Responses to Experimental Rhinovirus Infection | NCT03508479 | Contradiction |
2,648 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Patients will be recruited in the general surgery clinic once the presence of an
operable, inguinal hernia has been identified.
- All patients with a unilateral, symptomatic, inguinal hernia, and
- Who are surgical candidates for a laparoscopic ingu... | Characterizing Stray Energy Injuries During Robotic Surgery | NCT03477201 | Entailment |
5,856 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Age is over 20 years old, under 75 years old, men or women
- Patients diagnosed with erosive esophagitis by gastroscopy
- Signed the informed consent forms
Exclusion Criteria:
- Patients who is impossible to receive gastroscopy
- ... | Efficacy of DA-5204 on Gastroesophageal Reflux Disease | NCT03998969 | Contradiction |
4,810 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Major subjects of over 40 years (mean age of Meniere's disease 40 to 50 years)
- Informed consent signed
- Medical examination performed prior to participation in research
- Patients with clinical criteria of Meniere's disease according to the classi... | Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease | NCT02530931 | Entailment |
597 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Patients with missed miscarriage up to 10 weeks from the last menstrual period
- Patients are able to provide written consent
- Patients with no underlying medical conditions
Exclusion Criteria:
- Inability to consent due to cognitive or lan... | Treatment of Missed Miscarriage With TRUCLEAR Tissue Removal System, a Feasiblity Study | NCT04512820 | Entailment |
1,815 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | DISEASE CHARACTERISTICS: Histologically confirmed metastatic or recurrent adenocarcinoma of
the stomach or gastroesophageal junction Bidimensionally measurable or evaluable disease
Mediastinal or hilar lymph nodes assessed by CT or MRI scan must be at least 2 cm in
diameter to be considered meas... | Combination Chemotherapy in Treating Patients With Metastatic or Recurrent Cancer of the Stomach or Esophagus | NCT00005607 | Entailment |
3,564 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | Inclusion Criteria:
- solitary erythema migrans
Exclusion Criteria:
- pregnancy or lactation
- immunocompromised
- serious adverse event to doxycycline
- taking antibiotic with antiborrelial activity within 10 days
- multiple erythema migr... | Duration of Doxycycline Treatment in EM Patients | NCT03153267 | Entailment |
1,395 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- African American
- Hypertensive
- Owning a compatible smartphone
- Presenting to the Detroit Medical Center Detroit Receiving, Sinai-Grace Hospital, or
selected Community Health Screening Events with, but not necessarily for, uncontrolle... | MI-BP: mHealth to Improve Blood Pressure Control in Hypertensive African Americans | NCT02955537 | Contradiction |
4,035 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Men/Women aged over 20
- Subjects who are diagnosed with one- or both-sided knee osteoarthritis according to
the standards of clinical diagnosis from American College of Rheumatology(ACR)have
knee osteoarthritis pain and meet over three of the foll... | Clinical Trial of YYC301 for Treatment of Osteoarthritis of the Knee | NCT03850587 | Entailment |
3,632 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- presenting to ED with epistaxis or nasal fractures ( over 18 years)
Exclusion Criteria:
- laceration around site of mask, reduced GCS, concurrent head injury, systemic shock
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join th... | The Roles of Hilotherapy in the Management of Epistaxis and Nasal Fractures | NCT04279288 | Entailment |
6,107 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Age ≥18 years of age, inclusive, at the time of signing the informed consent.
2. Willing and able to provide informed consent via an electronic process.
3. Healthcare worker employed at a participating institution that has been identified as
high-risk... | COVID-19 Prophylaxis South Africa (COVER HCW) | NCT04561063 | Contradiction |
170 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Eligibility
Ages Eligible for Study:
- Adolescents (16-17yrs)
- Adults (18 years and older)
- Genders Eligible for Study:
- Male and Female
- Accepts Healthy Volunteers:
- No
Criteria
Inclusion Criteria:
... | Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS) | NCT00392756 | Entailment |
4,691 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Subjects were male or female, aged between 18 and 65 years inclusive.
- Subjects had a BMI of between 19 and 30 kg/m2 inclusive.
- Prior to study commencement, subjects signed and dated a witnessed informed consent
form.
- Subjects had a... | Clinical Trial of Tahitian Noni Juice Safety | NCT01424748 | Entailment |
6,885 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
The patients with amnestic MCI
The patients with single domain amnestic MCI have a Clinical Dementia Rating score of 0.5
with isolated memory impairment without deficits in other cognitive domains. A cutoff
scores below 1.5 Standard Deviation (SD) (or 7 percentile) ... | Imaging the Neural Network Connectivity on Patients With Mild Cognitive Impairment | NCT01927653 | Contradiction |
1,969 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Subjects undergoing upper gastrointestinal endoscopy
Exclusion Criteria:
- Patients with a history of thoracotomy with resection of lung tissue
- Patients with a history of severe chronic obstructive pulmonary disease (defined as an
inabili... | An Evaluation of the Utility of the ExSpiron Respiratory Variation Monitor During Upper GI Endoscopy | NCT02310230 | Entailment |
2,359 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Ambulatory and Non-ambulatory patients diagnosed with DMD that is proven both
clinically and genetically and are between 5-20 years old who need partial respiratory
support daily. Patients with less than or equal to stage 1 NIH, cardiac, liver, and
... | Efficacy of Stem Cell Therapy in Ambulatory and Non-ambulatory Children With Duchenne Muscular Dystrophy - Phase 1-2 | NCT02484560 | Entailment |
139 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- men presenting ADAM according to their responses on the Aging Male Symptoms Scale and
testosterone levels <220 pmol/l
Exclusion Criteria:
- history of neurological or musculoskeletal diseases or who have prostate cancer will
be excluded, a... | Physical Exercise for Men With Andropause | NCT03150225 | Contradiction |
6,738 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. Under going extraction of tooth including the surgical extraction.
2. Healthy individual with no known medical problems.
3. Not allergic to foreign body.
4. Extractions which are not due to periodontal causes.
Exclusion Criteria:
1. ... | Radiographic Assessment of Bone Regeneration in Alveolar Sockets With PLGA Scaffold | NCT00836797 | Contradiction |
1,528 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
-
You are eligible to participate in this study because you meet all of our selection
criteria:
- You are between ages 18-50
- You are right-handed
- You are able to receive a MRI scan (you have no metal implants or other metal objects
... | MEG Study of Mindfulness Based Stress Reduction | NCT00571051 | Contradiction |
2,845 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria
Patients entering this study:
- Are between the ages of 18-80 years old.
- Legal residents of the United States or Canada.
- Have a history of a chronic onset of a progressive motor weakness of less than 24
months duration.
- Fulfi... | Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) Trial | NCT00035815 | Entailment |
718 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Male or female ≥21 years and ≤60 years old and with BMI ≤40
- Moderate to severe knee OA pain ≥3 and ≤8 on the NRS pain subscale in the affected
knee (signal knee)
- Mild or no pain ≤3 on the numeric rating scale (NRS) pain subscale in the
... | 2 Weekly Intra-articular Hyaluronan Knee Injections, Given 1 wk. Apart, of HYMOVIS Combined With Physical Exercise Program (PEP) Compared to PEP Alone, in Relatively Young, Active Population of Subjects With Patellofemoral Osteoarthritis (PFOA) and/or Tibiofemoral Osteoarthritis (TFOA) | NCT03281837 | Contradiction |
1,237 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Requiring Tunneled Catheter Placement for a Pleural Effusion
Exclusion Criteria:
- Patient with a nonexpandable lung
- Non-english speaker
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must b... | Betadine Pleurodesis Via Tunneled Pleural Catheters | NCT02975921 | Entailment |
4,184 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Male or female subjects, aged 18 to 65 years.
2. Physician diagnosis of mild intermittent allergic asthma (GINA I according to GINA
guidelines9).
3. Normal lung function parameters at baseline (FEV1 > 80 % of predicted)
4. Non smoker or smo... | Characterization of Aerosol Generation and Transport in the Human Lung | NCT01095627 | Contradiction |
28 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Volunteers patients with hypogonadism
Exclusion Criteria:
- Coronary heart disease
- Other pituitary/hypothalamic disorders or other non-hypogonadism diseases
- None was receiving vitamins, lipid-lowering drugs, or other medications known to... | Phase IV Study to Investigate the Effect of Testosterone Treatment on Paraoxonase Level in Male Patients With Hypogonadotrophic Hypogonadism | NCT01107067 | Contradiction |
5,578 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- at or above the age appropriate cut-offs for overweight (OW) or obese (OB) on WHO
growth charts: ≥85-97% for OW and >97% for OB for BMI
- between 10 and 18 years old
- menarcheal
- low dairy consumers (0-2 svgs/d and <700 mg Ca/d measure... | Does Dairy Benefit Bone & Body Composition in Overweight Girls Undergoing a Weight Management Program? | NCT02581813 | Contradiction |
4,098 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- Ages of 18 to 50 years (adult), inclusive.
- Have narcolepsy with or without cataplexy (Na-1 or Na-2) based on the International
Classification of Sleep Disorders (3rd edition) criteria (new or previously
diagnosed).
- Have undergone an... | A Study to Evaluate Safety, and Efficacy of SUVN-G3031 in Patients With Narcolepsy With and Without Cataplexy | NCT04072380 | Entailment |
3,895 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. All patients ages 30-80 with chronic painful knee osteoarthritis who would undergo
treatment by genicular nerve radiofrequency ablation.
2. Knee pain for at least 6 months.
3. Kellgren-Lawrence knee osteoarthritis of 2 or greater.
4. Pain r... | Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain | NCT02578108 | Entailment |
6,918 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- All participants:
- Normal Education> 7 years
- French mother tongue
- right-handed (Edinburgh Inventory)
- score on the scale of Beck <7 (depression scale)
- signing the informed consent of the protoc... | Cerebral Substrates of Prospective Memory in Young and Its Disruption in Normal Aging and in Alzheimer's Disease: A Study in Anatomical MRI, Diffusion Tensor MRI and Functional MRI | NCT02522091 | Entailment |
5,371 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Being in the age range of 18-35
- To be of reproductive age,
- Not giving birth before, Healthy women with regular menstrual periods (those who have
bleeding between menstrual cycles for 3-8 days for 21-35 days),
- To be an undergraduate... | Does Yoga Done To Women With Premenstrual Syndrome Affect Inflammation Parameters? | NCT04821232 | Contradiction |
4,342 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | - INCLUSION CRITERIA:
An individual who is affected with a disorder under study. Our initial list of exemplar
disorders has been discontinued; these disorders were examples of those which meet the
general attributes for inclusion in this protocol. As stated above, individuals with
diso... | Whole Genome Medical Sequencing for Genome Discovery | NCT01087320 | Entailment |
6,879 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | - Participants must meet National Institute of Neurological Disorders and Strokes, and
Alzheimer's Disease and Related Disorders Association (NINDS/ADRDA) criteria of
probable Alzheimer's disease of mild to moderate severity.
- Age at inclusion into study is between 62 and 85 year... | COGNIShunt® System for Alzheimer's Disease | NCT00056628 | Contradiction |
5,106 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Random population-based sample of women:
- Age 35-40 yr
- residing in the city of Oulu, Finland
- in March 2002
Exclusion Criteria:
- cardiovascular, musculoskeletal, respiratory, or other chronic diseases that mig... | Bone Adaptation to Impact Loading | NCT00697957 | Contradiction |
6,609 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. Severe hemophilia A (FVIII: C<2%),
2. Age 1-7y
3. Historical bleeding in any knee, elbow and ankle joint (s),
4. >50 EDs irrespective of FVIII product, including human coagulate factor and
recombinant factor VIII
5. No inhibitor ... | A Clinical Phenotype Based Individualized Prophylaxis in Chinese Hemophilia A Children | NCT02999308 | Contradiction |
306 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Good general overall health with no chronic medical conditions that result in periodic
exacerbations requiring significant medical care.
2. Age 18-35 years, inclusive, at the enrollment visit. (Note: subjects must be at least
18 years of age to prov... | Study of Efficacy, Cycle Control, and Safety of a NES-E2 Contraceptive Vaginal Ring | NCT03432416 | Contradiction |
5,120 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
Women above the age of 50 years with the diagnosis of postmenopausal primary osteoporosis
may be enrolled in the trial if the following inclusion/exclusion criteria apply.
All inclusion criteria must be answered "yes" for a subject to be enrolled in the trial.
1.... | Sequential Treatment of Postmenopausal Women With Primary Osteoporosis (FP-001-IM) | NCT00365456 | Contradiction |
3,776 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Males or females in the age 20 - 70 years (both inclusive)
2. Radiographic evidence of grade 2 to 3 osteoarthritis based on the Kellgren and
Lawrence radiographic entry criteria.
3. History of primary idiopathic osteoarthritis of the knee characterize... | Allogeneic Mesenchymal Stem Cells for Osteoarthritis | NCT01448434 | Entailment |
1,132 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- LV wall thickness ≥ 15 mm in one or more myocardial segments that is not explained by
loading conditions
- LVOT gradients ≥ 30 mmHg at rest and/or ≥ 50 mmHg at Valsalva's maneuver or exercise
- NYHA ≥ III
Exclusion Criteria:
- <... | The Effect of TASH in Patients With HOCM | NCT04066777 | Entailment |
6,133 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Healthcare professionals from all disciplines
- Technicians from all disciplines (health related)
- Working in a face-to-face manner during the pandemic in the services of health
institutions
- Professional or technical personnel in char... | Health Care Workers' Perception of Patient Safety During COVID-19 Pandemic | NCT04576299 | Contradiction |
2,411 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Evidence of signed and dated informed consent/assent document(s) indicating that the
participant (and/or his parent/legal guardian) has been informed of all pertinent
aspects of the trial.
- Ambulatory (10 meters walk/run in less than [<] 30 second... | A Study to Assess Dystrophin Levels in Participants With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD) Who Have Been Treated With Ataluren | NCT03796637 | Entailment |
4,011 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Meet the America College of Rheumatology (ACR) criteria for clinical knee OA assessed
by a rheumatologist
- Knee pain, visual analogue scale (VAS) pain at least 40mm
- Kellgren-Lawrence(K-L) grade of 2-4
- Physical examination showed sig... | Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis | NCT03815448 | Entailment |
193 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Diagnosis of idiopathic hypogonadotropic hypogonadism or Kallmann Syndrome
- mean testosterone level less than 300 ng/dl
- stable weight for the previous 3 months (no weight change greater than or equal to 10
lbs)
- normal serum TSH
... | Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH) | NCT03118479 | Entailment |
1,533 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. A male and a female subject aged: 18 - 60 years inclusive.
2. All subjects must be generally healthy and in a mutually monogamous heterosexual
relationship - current relationship ≥ 3 months.
3. All couples must be sexually active, and agree to have pe... | A Clinical Investigation to Assess the Performance of Natural Rubber Latex Condoms in Couples | NCT03739190 | Contradiction |
5,080 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Ambulatory postmenopausal women, who had their last menstrual period at least 2 years
before beginning the study
- Free of severe acute or chronically disabling conditions with a life expectancy of at
least 5 years
- Expected to remain ... | Safety and Efficacy of Whole-body Vibration as add-on Treatment of Osteoporosis in Post-menopausal Women | NCT01415050 | Contradiction |
6,678 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Diagnosis of inherited, severe (FVIII:C < 1%) or moderately severe haemophilia A
(FVIII ≤ 2%)
- Any age
- Ability to comply with study methods and willingness to participate to the study
- Written informed consent.
FOR THE LOW R... | Thrombin Generation Assay (TGA) as Predictive Test for Haemostatic. Effectiveness of FVIII Concentrates in Haemophiliac A With Inhibitors | NCT01505946 | Contradiction |
4,166 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Healthy male or female subjects in good health as determined by past medical history
- physical examination, vital signs and safety lab at screening
- between 18 to 45 years of age
Exclusion Criteria:
- Significant illness
- preg... | Safety and Pharmacokinetics of a Novel Niclosamide Solution in Combination With Camostat | NCT04644705 | Contradiction |
6,846 | 49 | A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating. She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems ... | I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not un... | Inclusion Criteria:
- Idiopathic inflammatory myopathies
Exclusion Criteria:
- Inclusion body myositis, muscular dystrophies, neoplasia-associated myopathies,
overlapped myopathies, others myopathies
No condition on gender to be admitted to the trial.
No healthy subjects ac... | Optimizing Treatment on Idiopathic Inflammatory Myopathies | NCT03092180 | Entailment |
1,017 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Patients with symptomatic Kellgren-Lawrence (KL) Grade 2, 3, or 4 OA by radiograph (AP
tunnel view) within 30 days prior to day 0 visit, where the K-L grades are defined as:
- Grade 0: no radiographic features of OA are present
- Grade 1: ... | Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients | NCT03980964 | Entailment |
4,932 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- having a diagnosis of essential tremor (ET) based on Movement Disorder Society
criteria, involving at least one hand.
- 18 years or above
- cognitively eligible to give informed consent of participation in the trial.
Exclusion Criteria:
... | Cerebellar rTMS for Essential Tremor | NCT02704793 | Entailment |
6,916 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
General inclusion criteria
- Be older than18 years old.
- Consulting in one of the centers (patients only)
- Sufficient cognitive capacities for the realization of the clinical and
neuropsychological evaluations, left to the judgement by the ... | Hippocampal Sclerosis and Amnesia Not Due to Alzheimer's Disease | NCT02576821 | Entailment |
2,350 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Duchenne muscular dystrophy genetically confirmed;
- Males between 6 and 14 years old;
- Able to walk independently at least 75 meters;
- Patients on a stable dose of corticosteroids at least 6 months prior to baseline;
- Patients able to... | Rimeporide in Patients With Duchenne Muscular Dystrophy | NCT02710591 | Entailment |
4,720 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Healthy adult aged between 19 and 45 years, inclusive, at the time of providing the
informed consent form
2. body weight: ≥ 55kg(male), ≥ 50kg(female)
3. BMI: 18.5 kg/m2 ≦ BMI < 25.0 kg/m2 [BMI(body mass index) = Body weight (kg)/[height
... | Evaluation of the Food Effect on the Safety, Tolerability, PK of EC-18 After Oral Administration in Healthy Volunteers | NCT02700360 | Entailment |
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