id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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5,150 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Patient identified as being at an increased risk of osteoporosis by the data capture
system
Exclusion Criteria:
- Known osteoporosis.
- Patients treated with alendronate.
- Patients below 25 years of age.
- Bone meta... | Screening for Osteoporosis in General Practice | NCT02220699 | Contradiction |
5,949 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Healthy volunteers in the age between 19 and 50 years old.
- Body mass index (BMI) in the range of 19 to 28 kg/m2 and weight 55.0kg to 90.0kg.
- After fully hearing and understanding the details of this clinical trial, Subjects who
have willingness ... | Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of HIP1802 to HGP1705 in Healthy Volunteers | NCT04324905 | Contradiction |
3,107 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- diagnosis of moderate to severe dry eye syndrome with or without Sjögren's syndrome
- receiving treatment with topical cyclosporine (Restasis)
- experience one or more moderate dry eye-related symptoms, including dryness, foreign
body sensation, bur... | Pilot Study of a Homeopathic Therapy in Combination With Cyclosporin (Restasis) in the Treatment of Dry Eye Disease | NCT01072526 | Contradiction |
5,887 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patients with age of 20-75 years old (inclusive) in Taiwan of both genders
- Out-patients who had been diagnosed as non-erosive gastroesophageal reflux disease
(NERD)
- Patients with heartburn or regurgitation (either one) as main symptom at least 2... | Efficacy and Safety of Sodium Alginate Oral Suspension to Treat Non-erosive Gastro-esophageal Reflux Disease | NCT01338077 | Contradiction |
408 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Female, age 18-50 years, inclusive
- General good health (by volunteer history and per investigator discretion) without any
clinically significant systemic disease (including, but not limited to significant
liver disease/hepatitis, gastrointestinal... | Safety, PK, and PD Study of IVRs Releasing TFV and LNG | NCT03279120 | Contradiction |
4,302 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Healthy males or females aged between 18-40 years.
2. Willing and able to complete all study procedures, visits and restrictions.
3. Capable of giving written informed consent.
4. Has been determined healthy by medical history, physical and vital signs ... | Phase Ib Study of Safety, Tolerability and Pharmacokinetics of Elpida Once Weekly in Healthy Volunteers | NCT03730311 | Entailment |
3,438 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Any participants over 21 years of age and under 80 who do not have an end-stage disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 80 Years | Epidemiology of Hearing Loss in Diabetic and Non-Diabetic Veterans | NCT00018486 | Entailment |
1,502 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Men and women over 40 years of age, who meet at least one of the following criteria:
1. have established cardiovascular disease: Coronary Artery Disease, Cerebrovascular
disease (documented stroke and/or TIA), and Peripheral Vascular Disease;
... | Improved Delivery of Cardiovascular Care Through Outreach Facilitation | NCT00574808 | Entailment |
1,817 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. pathologically diagnosed gastric adenocarcinoma
2. Type II and III esophageal-gastric-junction malignancy
3. AJCC stage II-III
4. No contraindications for surgery, radical resection can be expected
5. KPS>60; ECOG score:0-2
6. Expa... | Neoadjuvant Chomotherapy With Paclitaxel-albumin and S-1 for Advanced Gastric Cancer | NCT04258657 | Entailment |
4,400 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Patients eligible for inclusion in the study will have had symptoms for at least 9
months and have failed conservative management.
Exclusion Criteria:
- Significant prior elbow trauma will be excluded alternative diagnoses that better
expl... | Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement | NCT02236689 | Contradiction |
471 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women undergoing frozen embryo transfer.
Exclusion Criteria:
- Women older than 40 years
- Women who have any uterine anomaly or intrauterine pathology such as:
Endometrial polyp or/ and Large fibroid with a diameter >4 cm
- Visible... | Endometrial Leucocytes Around the Time of Embryo Implantation in Women Undergoing in IVF-ET | NCT04079959 | Contradiction |
3,824 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Will be included patients older than 18 years, who have moderate to strong chronic
pain in knee on most of the days days for at least 3 months, with osteoarthritis of
the knee documented by graded radiologically at 3 to 4 in Kellgren-Lawrence rating,
... | Saphenous Nerve Radiofrequency for Knee Osteoarthritis Trial | NCT02826850 | Entailment |
2,152 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Subject meets one or more criteria for the diagnosis of gout as per the American
Rheumatism Association Criteria for the Classification of Acute Arthritis of Primary
Gout.
- Subject has a body weight ≥ 50 kg (110 lbs.) and a body mass index ≥ 18 an... | RDEA3170 and Allopurinol Combination Study in Gout Subjects | NCT02279641 | Contradiction |
3,596 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- 18 years or older
Exclusion Criteria:
- history of nasal surgery, currently using topical nasal steroid spray, over the
counter decongestant, history of recurrent epistaxis or history of nosebleed within 2
weeks prior to data collection, c... | Analysis of Impact on Nasal Obstruction by Commercially Available Internal Nasal Stents | NCT00683254 | Contradiction |
2,417 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion criteria (DMD):
1. Genetically or histologically established diagnosis of DMD
2. Male, age 2 - 30
Inclusion criteria (Control):
1. Male, age 2 - 30
Exclusion criteria (DMD):
1. Presence of implanted pacemaker or other electrical device
2. ... | Electrical Impedance Myography and Ultrasound as Biomarkers of Duchenne Muscular Dystrophy | NCT01491555 | Entailment |
4,672 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women aged 18 or older
- Heterosexual
- Experiencing regular menstrual cycles (not more than 1 missed menstrual period in the
past 6 months).
- Currently involved in a stable, sexually active relationship.
- Fluent in the Eng... | Effects of Caffeine on Women's Sexual Arousal | NCT01242046 | Entailment |
2,076 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Man woman over 18 years old
- Certain or probable Idiopathic Pulmonary Fibrosis determined by a multi-disciplinary
discussion ("ATS / ERS / JRS / ALAT" 2018 criteria)
- Idiopathic Pulmonary Fibrosis with a diagnosis of less than 12 months
... | Influence of Socioeconomic and Environmental Factors on the Natural History of Idiopathic Pulmonary Fibrosis | NCT04619199 | Entailment |
2,710 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Hip and/groin pain more than 6 weeks
- Physically active
Exclusion Criteria:
- Systemic diseases
- Physically inactive
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
| Development of Outcome-measures for Physically Active Patients With Hip and Groin Pain | NCT00716729 | Entailment |
6,453 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Patients with moderate to severe facial telangiectasias referred to laser or
IPL-treatment. Severity and distribution of telangiectasias must be symmetrical
between left and right side of the face in the individual patient
- Telangiectasias may be ... | Topical Brimonidine to Reduce Inflammation After IPL-treatment in Patients With Facial Telangiectasias | NCT02761174 | Entailment |
5,099 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
Cases are admitted acutely for a femoral neck fracture, a trochanteric or a subtrochanteric
femoral fracture.
Exclusion Criteria:
- Hip fracture as part of multi-trauma or high energy trauma (defined as a fall from a
higher level than 1 metre). One ... | Nutritional Risk Factors for Hip Fracture: a Case Control Study | NCT01738776 | Contradiction |
5,837 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- age 18 years or older
- diagnosis of GERD established by either
- 24-h oesophageal pH monitoring (performed off medications) showing an abnormal
OAE (pH < 4 at least 4% of time) and/or
- an upper gastrointestinal (GI) endo... | Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease | NCT03223116 | Contradiction |
5,300 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Healthy postmenopausal women age 50 years or older
- At least three lumbar vertebrae (L1-L4) must be evaluable by dual energy x-ray
absorptiometry (DXA) for bone mineral densitometry that is, without fracture or
significant degenerative disease, as... | Dose Ranging Study - Macroflux Parathyroid Hormone (PTH) in Postmenopausal Women With Osteoporosis | NCT00489918 | Entailment |
3,296 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
1. Male and female participants
2. Age 20-50
3. Bilateral sight impairment due to Stargardt's disease, retinitis pigmentosa or
albinism.
4. Sight impairment criteria are as follows:
- Visual acuity of 3 / 60 to 6 / 60 with a f... | Visual Performance Measures in a Virtual Reality Environment for Assessing Clinical Trial Outcomes in Those With Severely Reduced Vision | NCT04281732 | Contradiction |
4,309 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion criteria:
Men:
- in a partnered relationship with a female
- have been trying without success to conceive a pregnancy
- have been referred due to suspected or diagnosed male-factor infertility
- have the ability to read and write English
Female... | Understanding Adaptive Challenges Associated With Male-factor Infertility | NCT02607098 | Entailment |
5,717 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Children of either sex who are treated with NutropinAq® for the treatment of growth
failure
- Patients who are willing to comply with follow-up appointments throughout study
participation
- Written informed consent signed by both parent... | A Post Marketing Surveillance Program for NutropinAq® in Paediatric Growth Disorders | NCT00455728 | Entailment |
6,608 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- documented circulating FVIII level of ≤1%
- age 3 - 20 years
- may be on primary or secondary prophylaxis
- granting of informed consent
Exclusion Criteria:
- measurable inhibitor level at the time of enrollment
- ing... | Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function | NCT02225483 | Contradiction |
1,795 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | - INCLUSION CRITERIA
1. Patients older than 16 years with well-differentiated papillary or follicular
thyroid cancer stage I or II, according to the NTCTCS classification at time of
surgery
2. Patients younger than 45 years with any size of primary pa... | Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer | NCT00251316 | Contradiction |
1,342 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
1. Legally authorized representative is willing and able to provide written, signed
informed consent (with a written assent from the child when appropriate per local
requirements)
2. Willing and able to comply with study protocol per investigator judge... | A Multi-center, Longitudinal, Observational Study of Children With Achondroplasia | NCT03875534 | Entailment |
4,007 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria (Screening Visit 1):
1. Osteoarthritis (OA) of the knee by American College of Rheumatology criteria
2. Men or women between 45-80 years of age.
3. Have documented diagnosis of primary OA of the target knee based on clinical and
radiographic criteria (Kel... | Study of Intra-articular Injections vs Placebo in Patients With Pain From Osteoarthritis of the Knee | NCT01887678 | Entailment |
6,082 | 45 | A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is o... | My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor dia... | Inclusion Criteria:
- Clinical diagnosis of Down syndrome
Exclusion Criteria:
- History of congenital cardiac defects requiring open-heart surgery
- History of gastroenterologic anomalies requiring bowel resection and/or ongoing
medical intervention
-... | Frequency of Metabolic Syndrome in Down Syndrome Patients | NCT00864461 | Contradiction |
4,115 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Healthy subjects:
- Normal PFT values: FEV1 > 90% predicted; and Forced vital capacity (FVC) > 90%
predicted
- Normal chest x-ray (CXR)
- Medical history: No active pulmonary symptoms (cough, shortness of breath,
... | Study of Airflow in the Lungs Using Helium MRI | NCT02154568 | Contradiction |
5,690 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Turner syndrome
- If age below 3 years, either body height below - 1 SD (standard deviation) with
average growth velocity according to chronological age or body height below 0 SD with
growth velocity below -1 SD according to chronological age
... | Growth Response in Girls With Turner Syndrome | NCT01734486 | Entailment |
1,606 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Adults of all races and ethnicities
- Age 21-45; BMI 20-27 kg/m2
- stable weight (+/- 10 lbs) over the previous 6 months
- Women must be pre-menopausal with regular menstrual cycles.
Exclusion Criteria:
- Regular exercise more th... | Randomized Study of Daytime vs. Delayed Eating: Effect on Weight and Metabolism | NCT04414644 | Contradiction |
4,546 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women aged 20-40 years
- Women with ultrasonographic evidence of adenomyosis
- Woman complains of vaginal bleeding or pelvic pain related to adenomyosis
Exclusion Criteria:
- Women with a history of malignancy or histological evidence of end... | Dienogest for Treatment of Adenomyotic Uteri | NCT03890042 | Contradiction |
3,355 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Above 16 yrs old and less than 50 yrs old.
2. Clinically diagnosed central tympanic membrane perforations or chronic suppurative
otitis media (tubo-tympanic).
3. Dry ear: no otorrhea without medication for at least 1 month.
4. Hearing loss ... | Tragal Perichondrium Versus Pretragal Fascial (SMAS) Graft for Endoscopic Myringoplasty | NCT04687995 | Contradiction |
723 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Ambulatory adults of either sex aged 40 to 60 years.
- Subjects with moderate OA of the knee, which can be clinically, categorized as ARA
functional Class II and III with radiological confirmation of Kellgren Lawrence Grade
II and III. (incase of b... | Study to Assess the Effect of E-OA-07 on Acute Pain Response in Subjects Suffering From Knee OA | NCT02417506 | Contradiction |
1,994 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. histologically proven adenocarcinoma of the stomach
2. preoperative suspicion of serosal invasion on the radiological examination
3. candidate for curative resection of the stomach with D2
4. age from 19 to 70 year old
5. Eastern Cooperative ... | Intraperitoneal Chemotherapy and Systemic Chemotherapy Versus Systemic Chemotherapy After Curative Resection of Serosa-positive Gastric Cancer | NCT02205008 | Entailment |
6,605 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Diagnosis of hemophilia A
- Age of 12 Years to 65 Years，Diagnosis of severe （defined as <1% FVIII:C documented in
medical records） or moderately severe（defined as 1%-5% FVIII:C documented in medical
records） hemophilia A .Subjects who（Age of 18 Yea... | Evaluate Efficacy and Safety of Recombinant Factor VIII （rFVIII）Treatment of Severe or Moderately Severe Hemophilia A | NCT02930317 | Contradiction |
6,848 | 49 | A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating. She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems ... | I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not un... | Inclusion Criteria:
- Skin rash typical of dermatomyositis: "lilac" rash (+/- oedemata) of upper eyelids,
periungual sign, erythematous-scaly eruption occurring over the MCP and IPP, elbow,
knees (Gottron's signs ands papules), erythema of light-sensitive areas OR
- Mus... | Diagnostic Accuracy of Whole Body Magnetic Resonance Imaging in Inflammatory Myopathies | NCT01432613 | Entailment |
1,704 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Women with age comprised between 18 and 45 years
- Normal uterus (evaluated trough ultrasound 2D/3D and/or hysteroscopy)
- Presence of at least one ovary
- Body mass index:
- Normoweight: 18.0-24.9 kg/m2 and non smokers
- Obes... | Maternal Transcriptomic Regulation of the Preimplantation Embryo | NCT02813746 | Entailment |
3,260 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- autoimmune or infectious disease
Exclusion Criteria:
- No
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Lymphocyte Sub-populations and Auto Immune Diseases | NCT03901664 | Entailment |
470 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age between 20 and 35 years old.
- Body mass index between 20 - 30.
- Unexplained infertility .
- Follicle-stimulating hormone level 12 IU/L or lower (baseline level, cycle day 3).
- Normal hysteroscopy ( healthy uterus with no fibroids o... | Effect of Vitamin D Status on Clinical Pregnancy Rates Following Intra Cytoplasmic Sperm Injection | NCT02987478 | Contradiction |
6,310 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Fluent in English
- Tested positive for COVID-19
Exclusion Criteria:
- Prisoners
- Unable to provide own informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at ... | Symptom-Based Markers for COVID-19 Transmission | NCT04665245 | Entailment |
3,988 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Symptoms of osteoarthritis of the hip or knee for a minimum of six months
- History of hip or knee pain due to osteoarthritis requiring the use of NSAIDs,
acetaminophen or another analgesic agent on a regular basis (>= three days/week) for
at least... | An Effectiveness and Safety Study of Acetaminophen Extended Release Caplets in the Treatment of Osteoarthritis of the Hip or Knee. | NCT00240799 | Entailment |
5,237 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal woman (for at least 5 years) or men who are aged between 45 to 85
- Participant who has low bone mineral density
- Participant has anatomy suitable for dual-energy x-ray absorptiometry (DXA) of the
lumber spine and hip
- P... | Efficacy and Safety of Odanacatib (MK-0822) in Participants With Involutional Osteoporosis (MK-0822-022) | NCT00620113 | Entailment |
5,586 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Pre pubertal children
- Study group: BMI precentiles over 85 (overweight and obese children)
- Control group: BMI precentiles between 5-85 (normal weight children)
Exclusion Criteria:
- Children with organic Disease
- Competitive... | The Effect of Information on Physical Fitness Measures and Training in Overweight Children | NCT03165604 | Contradiction |
3,894 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Had unilateral or bilateral knee OA
- Knee OA K&L grade ≥ 2
- VAS = 3 cm over the previous 24 hours
- Able to walk ≥ 6-meter distances with or without an aid
Exclusion Criteria:
- Had knee or lower limb surgery
- Oral... | The Effect of Mobilization With Movement on Pain and Function Among Patients With Knee Osteoarthritis | NCT02865252 | Entailment |
4,973 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Males and females, 35-75 years old with a diagnosis of essential tremor with symptoms
clearly present in at least 1 upper limb; patient has had tremor present for at least
2 years prior to Screening
- Off medication, or on a stable dose of medicati... | Evaluate SAGE-547 in Patients With Essential Tremor | NCT02277106 | Entailment |
4,102 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
Group "Narcoleptic Patients":
- Type 1 or Type 2 narcolepsy
- > 18 years
- Usually followed at the Lyon Sleep Medicine Center
Group "Control":
- At least one member of each family of cases (siblings, cousins ...)
- > 18 ye... | Evaluation of Academic and Professional Trajectories of Narcoleptic Patients | NCT03173378 | Entailment |
4,686 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Subjects in good health as confirmed by medical history, physical exam, and PAP smear
within the preceding six months
- Non-smokers, if between 35 and 45 years of age
- Patients who are not pregnant or lactating
- Had at least one normal... | An Open-Label Study Evaluating Breakthrough Bleeding and Spotting With Norgestimate/Ethinyl Estradiol Tablets Administered as an Extended Regimen | NCT00344383 | Entailment |
3,802 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Signed informed consent.
- 18 years of age, or older.
- Capable of completing the diary card.
- Ability to complete the HRQL questionnaires.
- A clinical diagnosis of a chronic condition (e.g., osteoarthritis or rheumatoid
ar... | Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs | NCT00241527 | Entailment |
824 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Knee pain most of the days the last month
- Over 38 years old
- Crepitus on active motion
- Morning stiffness less than 30 minutes
Exclusion Criteria:
- Not been diagnosed for current knee pain
- Non-traumatic cause d... | A Cost-efficiency Analysis of Primary Assessors for Patients With Knee Pain in Primary Care | NCT03822533 | Entailment |
4,416 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- aged between 18-70 years
- pain on the lateral side of the elbow for less than six months
- tenderness over the lateral epicondyle
- pain during extension of wrist and fingers
Exclusion Criteria:
- upper extremity and neck disord... | Comparing the Efficacy of Continuous and Pulsed Ultrasound Treatments in Lateral Epicondylitis | NCT03944122 | Contradiction |
722 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Age ≥ 18 years old
- Pain intensity on a self-administered 11-point pain numeric rating scale ≥ 30
- Pain involving the base-of-thumb
- X-ray evidence of base-of-thumb osteoarthritis with at least 2 of the 4 following
items involving the... | Efficacy of an Intra-articular Injection of Botulinum Toxin A Associated With Splinting for Base-of-thumb Osteoarthritis | NCT03187626 | Contradiction |
6,421 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Subject is male or female aged 18 years or older.
2. Subject has a clinical diagnosis of facial rosacea.
3. Subject has a clinician's assessment score of moderate to severe erythema prior to
enrollment.
4. Subject has a self assessment scor... | Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea | NCT01659853 | Entailment |
2,380 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Male
- Age 8 years to 17 years
- Non-Ambulatory (unable to complete 10m run/walk under 10s)
- Weight </=100Kg
- Diagnosis of DMD confirmed by at least one the following:
- Dystrophin immunofluorescence and/or immunoblot s... | Plus Epicatechin Duchenne Muscular Dystrophy in Non-ambulatory Adolescents | NCT02964377 | Entailment |
5,992 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Patients over the age of 18 who have proven GERD (with nighttime heartburn at least 3
days a week).
2. Agree to undergo sleep positioning therapy.
3. Able to read, understand, and complete study questionnaires.
4. Have mobile phones with an... | The Effect of Positional Therapy on Symptoms of Gastroesophageal Reflux Disease: A Prospective Pilot Study | NCT04500288 | Entailment |
5,990 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Male or Female aged ≥18 years
2. Subjects with refractory reflux symptoms to PPIs standard treatment as follows:
2.1 Ongoing heartburn symptom with or without these GERD-related symptoms :
Regurgitation, Non-cardiac chest pain, Epigastric pain, Bel... | A New System for GERD Diagnosis and Treatment | NCT03600974 | Entailment |
5,573 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Eligible for the TIGER Kids primary study
- BMI >/= 85th percentile
- Height >/= 4 feet 6 inches
- Weight < 350 pounds
Exclusion Criteria:
- Anemia
- American College of Sports Medicine (ACSM) contraindications to exe... | Translational Investigation of Growth and Everyday Routines in Kids (TIGER Kids) Fitness Ancillary | NCT03611296 | Contradiction |
3,817 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients suffering from symptomatic knee OA (uni/bi lateral) for at least six months,
fulfilling the ACR clinical criteria for OA of the knee, and having radiographically
assessed OA of the knee according to the Kellgren and Lawrence scale.
- Patie... | The Effect of AposTherapy on Knee Pain | NCT03171168 | Entailment |
813 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patients seeking treatment at the primary health care for problems with their joints
(pain, stiffness).
Exclusion Criteria:
- Patients diagnosed with RA
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.... | Survivin as Predictive Biomarker for RA | NCT03444623 | Entailment |
2,053 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Any patient with malignant pleural effusion who will undergo palliative treatment with
insertion of intercostal tube.
Exclusion Criteria:
1. Patients <18 years old, unable to provide informed consent.
2. Had an allergy or other contraindicati... | Role of Chest Sonography in Evaluation of Pleurodesis in Patients With Malignant Pleural Effusion | NCT04074902 | Contradiction |
662 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
1. Male or female of 18-80 year old.
2. With blood transfusion history or RBC-transfusion-dependence.
3. BM smear and biopsy plus chromosome analysis within 3 months before signing ICF,
otherwise done during screening.
4. Excluding other disea... | Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload | NCT02833493 | Contradiction |
3,030 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Intellectual disability
- Age 15-60 years
- Low physical activity
- Sedentary lifestyle
Exclusion Criteria:
- Medical contradictions for participation
- High levels of physical activity
No condition on gender to be ad... | Physical Activity With Tailored E-health Support for Individuals With Intellectual Disability | NCT04079439 | Entailment |
4,581 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | - INCLUSION CRITERIA:
1. Female
2. Between 18 and 28 years of age (inclusive)
3. Reported menarche between the ages of 11 and 14 years
4. Gynecological age of less than or equal to 14 years
5. A history of self-reported regular menstrual c... | CaREFREE Study (Calorie Restriction, Environment and Fitness: Reproductive Effects Evaluation Study) | NCT02858336 | Contradiction |
4,766 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Clients 18 years and older with complaint of dizziness, vertigo, and/or imbalance who
are willing to proceed with procedures of study.
- Inclusion for control group: no history of dizziness, vertigo, and/or imbalance.
Exclusion Criteria:
- ... | Helpfulness of the Vibration Test Performed in Room Light on Clients With Inner Ear Problems | NCT02626052 | Entailment |
3,508 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
1. Male and female children less than 6 years of age.
2. A diagnosis of adrenal insufficiency as confirmed by an inappropriately low cortisol
usually with other supporting tests.
3. Receiving appropriate adrenocortical replacement therapy (hydrocortisone... | Treatment of Adrenal Insufficiency in Children | NCT02720952 | Contradiction |
648 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Undergoing liver biopsy for suspected or known hemochromatosis
- Undergoing liver biopsy for living-related liver donation evaluation
Exclusion Criteria:
- Contraindication to MRI
No condition on gender to be admitted to the trial.
Accepts Healthy Volun... | Evaluation of a New MR Pulse Sequence to Quantify Liver Iron Concentration | NCT00587535 | Contradiction |
5,249 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal women aged between 45 up to 75;
- Bone mineral density T score at the lumbar spine (L1-L4), femoral neck or total hip
should be equal or less than -2.5 and equal or more than -4. (-4 ≤ T score ≤-2.5); or
patients with high risk of fr... | Comparing Efficacy and Safety of AryoGen Pharmed Biosimilar Denosumab 60 mg (Arylia) Versus Prolia® in Improvement of Bone Mineral Densitometry (BMD) Among Osteoporotic Postmenopausal Women | NCT03293108 | Entailment |
4,712 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Age 30-60, female
- Symptomatic (Dysmenorrhea, Palpable mass, Pelvic pain or discomfort, Urinary symptom,
Increasing size, Menorrhagia) myomas or adenomyosis
- Suspected uterine myoma and/or adenomyosis on transvaginal ultrasonography (USG)
... | Study of Different Pain Scores in Single-Port Access (SPA) Laparoscopic Hysterectomy Versus Conventional Laparoscopic Hysterectomy | NCT01064128 | Entailment |
2,802 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Subjects with definite, probable, or laboratory supported probable ALS will be
eligible.
1. ALS diagnosed as probable, laboratory supported probable or definite according to
the World Federation of Neurology El Escorial criteria [Brooks et... | SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS) | NCT01083667 | Contradiction |
561 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Patients who have had hydatidiform mole treated by evacuation and/or curettage and now
meet the criteria of low risk GTN, as defined by the International Federation of
Gynecology and Obstetrics (F.I.G.O.)/World Health Organization (W.H.O.) 2002 staging
... | Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors | NCT00521118 | Contradiction |
2,540 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Clinical diagnosis of Atopic Dermatitis
- Children over 6 months.
- Teens lower than 19 years
No inclusion / Exclusion Criteria:
- Diagnostic presence or clinical signs suggesting acute or chronic skin diseases, as
well as perti... | Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children | NCT02519556 | Entailment |
6,580 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- As per investigator's judgement, a willingness and ability to comply with scheduled
visits, treatment plans, laboratory tests, and other study procedures, including the
patient-reported outcome (PRO) questionnaires and bleed diaries through the use of an
... | A Study to Evaluate the Safety and Tolerability of Prophylactic Emicizumab in Hemophilia A Patients With Inhibitors | NCT03191799 | Contradiction |
5,288 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Osteoporotic patients who meet any of the following condition:
1. with at least one fragility fracture,
2. above 70 year-old with bone mineral density below 70% young adult mean,
3. with bone mineral density below 60% young adult mean
... | A New Active Vitamin D, ED-71 for Osteoporosis | NCT00144456 | Entailment |
1,489 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Patient is at least 40 years of age
- Clinical diagnosis of osteoarthritis of the knee for greater than 6 months based on
clinical and radiographic criteria
- Female patients of childbearing potential must have a negative pregnancy test prior to
... | Safety and Efficacy of Etoricoxib 30 mg Versus Celecoxib 200 mg in Korean Participants With Osteoarthritis | NCT01554163 | Entailment |
4,635 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women scheduled for robotic assisted laparoscopic hysterectomy
Exclusion Criteria:
- Patients who will not consent.
- Hysterectomy due to malignant conditions.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.... | Vaginal Cuff Closure in Robotic Hysterectomy | NCT02696239 | Entailment |
4,009 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Adult patients with an American Society of Anesthesiologists (ASA) physiological
status I-III
2. Patients presenting for unilateral primary total knee replacement.
3. No focal neurologic deficit of the surgical lower extremity.
4. Cognitive... | Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA) | NCT02223364 | Entailment |
5,417 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- von Willebrand Disease (VWD) patients defined prepartum as Type 1 per National Heart,
Lung, and Blood Institute (NHLBI) criterion of von Willebrand Factor (VWF) level less
than 30 percent, or Type 2, or Type 3
- VWF and Factor VIII (FVIII) levels o... | Von Willebrand Factor in Pregnancy (VIP) Study | NCT04146376 | Entailment |
1,171 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Age of 18 - 60 years.
2. patients of both genders.
3. patients diagnosed as pleural effusion by the physician.
4. patients with asymmetrical chest expansion.
Exclusion Criteria:
1. Orthopedic conditions.
2. Pleural effusio... | the Effect of Chest Expansion Exercises on Pleural Effusion | NCT04553315 | Contradiction |
3,615 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Healthy volunteers over the age of eighteen that have been recently dismissed from the
Emergency Department at Mayo Clinic Hospital, Saint Marys Campus.
- We will recruit a convenience sample of 100 patients from the Emergency Department who
have c... | The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial. | NCT02285634 | Entailment |
1,438 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Age 60-85 years' old
- Both male and female patients
- ASA I-II
- Body mass index (BMI) ≤ 30 kg/m2
- Elective surgery under general anaesthesia with the use of laryngeal mask airway (LMA)
/ LMA Proseal / LMA Supreme
... | To Compare Effect of Sevoflurane Versus Desflurane on the Return of Swallowing Reflexes in the Elderly | NCT01833676 | Contradiction |
2,273 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Diagnosis of Duchenne muscular dystrophy confirmed by at least genetic testing,
theoretically treatable by exon 53 skipping.
- Age between ≥ 12 and <20 years old.
- Non ambulant patients (i;e; inability to walk more than 10 meters without any of
... | Observational Study of Patients With Duchenne Muscular Dystrophy Theoretically Treatable With Exon 53 Skipping | NCT01385917 | Contradiction |
6,417 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Male or female, who is at least 18 years of age or older at screening visit.
- Presence of chronic persistent vascular facial erythema for ≥ 3 months by history.
- A Clinician's Erythema Assessment (CEA) score of ≥3 at Screening and at Pre-dose (T0)
... | Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Persistent Facial Erythema | NCT01882712 | Contradiction |
5,363 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Male subjects between 0 and <12 years of age.
- Diagnosed with severe haemophilia A (FVIII:C <1%), and pre-treated for a minimum of 20
to 50 exposure days.
- Have evidence of vaccination against hepatitis A and B (or presence of antibodies
... | Study of Biostate® in Children With Hemophilia A | NCT01229007 | Contradiction |
545 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:Healthy females: 1) 18 years of age or older, 2) requesting an elective
termination of pregnancy by medical abortion, 3) with an intrauterine pregnancy no more
than 63 days gestation on the day of mifepristone administration as documented by
endovaginal ultrasound, 4) willing ... | Oral Mifepristone and Buccal Misoprostol Administered Simultaneously for Abortion Through 63 Days Gestation | NCT00330993 | Contradiction |
5,285 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Women with a diagnosis of osteoporosis of at-Risk
- Have a medical indication to receive Ibandronate+Vitamine D+Calcium
Exclusion Criteria:
- Osteoporosis due to secondary causes
Female
No healthy subjects accepted to join the trial.
Subject must be at ... | Antiresorptive Effects of a 6-m Treatment Course With Ibandronate Plus Supplementation of Vitamine D and Calcium in Central America | NCT02635997 | Entailment |
4,683 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women in the fertile age (between 20-45 years), not assuming oral contraceptives from
at least three months
- Referred normal menses .Use of the same brand of sanitary protection wear for the
whole of the period.
- BMI between 18 and 30... | Protocol for the Determination of Menstrual Losses in Healthy Women With Apparently Normal Cycles | NCT01276964 | Entailment |
2,674 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- primitive inguinal hernia
- age > 18 years old
- compliancy to the study
Exclusion Criteria:
- reccurent inguinal hernia
- age < 18 years old
- refusal of the study
No condition on gender to be admitted to the trial.
... | Absorbable Sutures , Non Absorbable Sutures or Biologic Fibrin Glue for Protesic Mesh Fixing in Lichtenstein Technique for Primitive Groin Hernia Repair: a Randomized Prospective Multicentric Trial | NCT02011698 | Entailment |
4,285 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Is either:
1. A healthy volunteer (i.e.: someone not diagnosed with a lung disorder written
below; this may include smokers who have not been diagnosed with a lung disorder)
or
2. Has been diagnosed with one of the fol... | Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders | NCT02748798 | Entailment |
2,503 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- The entire population of Manitoba is considered for inclusion.
Exclusion Criteria:
- Individuals less than or equal to 6 months of age;
- Having less than one year of insurance coverage before the enrolment period;
- Not registered with MH d... | A Database Study to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada | NCT02367222 | Entailment |
3,064 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
1. Adolescents with confirmed clinical and previous molecular diagnosis of FXS or AS, age
between 13 to 17 years, inclusive.
2. Subjects must assent to participation in the study (if appropriate), have a parent or
legal guardian/representative capable ... | Single Dose Pharmacokinetic (PK) Study | NCT03109756 | Entailment |
5,396 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Participants older than 18 years
- Participants presenting at the outpatient clinic for Mirena IUD insertion.
- Participants able to provide informed consent as documented by signature with at least
24 hours of reflection time
- Good und... | Usability, Safety and Efficacy of AspivixTM (Comparative Study) | NCT04441281 | Entailment |
3,289 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- Patient over 18 years old
- Patient with suspected NOIA, evoked after clinical examination by a specialized
ophthalmologist
- For which a brain and visual MRI is planned
- Express consent to participate in the study
- Affilia... | Diagnostic Accuracy of Optimized Diffusion-Weighted Imaging for Detecting Anterior Ischemic Optic Neuropathy | NCT04451265 | Contradiction |
4,414 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Age 18-70 years
- Pain from the lateral part of the elbow
- The pain increases on resisted dorsiflexion of the wrist with the elbow extended and
the fingers flexed or the pain increases on resisted radial deviation of the wrist or
the p... | Treatment Study of Steroid Injection and Physical Therapy for Acute Lateral Epicondylitis | NCT00826462 | Contradiction |
5,844 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- 18 to 80 yrs of age
- 2 to 3 episodes of GERD/week
- erosive esophagitis or abnormal 24 hr pH
- able to read and understand, complete questionnaires
Exclusion Criteria:
- barrett's esophagus or peptic stricture on endoscopy
... | Effect of Pantoprazole 40mg Daily vs Placebo on Power Spectral Analysis of the Sleep EEG of Patients With GERD. | NCT00674245 | Contradiction |
4,851 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Diagnosed with ACTH independent endogenous Cushing's Syndrome
- Available adrenal imaging prior to being treated with Korlym®
- Treated with Korlym® and followed for at least 3 months (follow-up data should be
available)
Exclusion Criteria:... | Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's Syndrome | NCT02663609 | Contradiction |
871 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Male and female
- Age group 50-75 years
- Knee osteoarthritis GI, GII and G III (Kellgren & Lawrence system).
Exclusion Criteria:
- Traumatic arthritis
- Unstable cardiovascular state
- Neuro-muscular disorders involv... | Effects of Anti-gravity Treadmill Training on Knee Osteoarthritis in Geriatric Population. | NCT04299568 | Entailment |
3,722 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
knee osteoarthritis aged 50 to 75 years knee pain lasting for than three months knee pain
intensity over 20 mm on Visual Analog Scale-VAS
Exclusion Criteria:
knee operation, Malignant diseases Systemic infectious diseases inflammatory diseases
Fibromyalgia ... | Knee Osteoarthritis, Kinesiophobia and Physical Activity | NCT03875040 | Contradiction |
6,012 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Cases:
- male or female patients aged between 21 and 65 years with typical clinical
manifestations of gastroesophageal reflux but endoscopy-negative for esophageal
mucosal breaks
- by typical clinical manifestations ... | Detection of Minimal Change Esophagitis Using Confocal Laser Endomicroscopy | NCT00954070 | Entailment |
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