id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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2,634 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Male, age 25 years or older
- Reducible, unilateral, inguinal hernia (not femoral hernia) that has not been operated
on before
Exclusion Criteria:
- The patient is not able or do not want to give written informed consent
- The p... | The Significance of the Mesh Thickness in the Operation of Inguinal Hernia | NCT00451893 | Entailment |
2,767 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- unilateral hernia
- uncomplicated hernia
- medical fitness for general anesthesia
Exclusion Criteria:
- unfit for general anesthesia
- complicated hernia
- uncorrectable coagulopathy
- BMI > 35
... | Study of Laparoscopic Inguinal Hernia Repair | NCT02920307 | Entailment |
1,119 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Patients of either gender, aged 18-75 years, with HCM caused by sarcomeric gene mutations
determined by existing protocols.
LV wall thickness of greater than or equal to 20 mm measured in any LV segment by MRI.
Severe symptoms refractory to medical treatment (New York Heart Association functio... | Cyclosporine A to Treat Hypertrophic Cardiomyopathy (HCM) | NCT00001965 | Entailment |
2,218 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Male or female 18 to 80 years of age;
- Previously met the preliminary criteria of the American Rheumatism Association (ARA)
for the classification of the acute arthritis of primary gout;
- At least 2 gout flares in the year prior to the screening v... | PREventative Study Against URate-Lowering Drug-Induced Gout Exacerbations (PRE-SURGE 2) | NCT00958438 | Contradiction |
6,004 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Females of childbearing potential who are sexually active must agree to use adequate
contraception, and can neither be pregnant nor lactating from Screening throughout the
duration of the study.
- History of nocturnal heartburn and GERD associated ... | A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn | NCT00627016 | Entailment |
5,784 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Pemphigus vulgaris patients having bilateral erosions in the buccal mucosa.
Exclusion Criteria:
- Pemphigus vulgaris patients who do not have oral erosions.
- Pemphigus vulgaris patients who have received intralesional steroid injection in their
... | Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris | NCT02828163 | Contradiction |
4,439 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Applying to Dokuz Eylül University Medical Faculty Physical Medicine and
Rehabilitation Department outpatient clinic
- Having pain in the elbow for less than 12 weeks and having no similar attack history
for 1 year
- Diagnosing lateral ... | Comparison of Two Different Splints in the Treatment of Lateral Epicondylitis | NCT04773249 | Contradiction |
1,760 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- aged greater than 20 years
- fulfill Rome III diagnostic criteria
Exclusion Criteria:
- children and teenagers aged less than 20 years
- Organic lesions such as ulcers, tumors, bleeding, vasculopathy or esophagitis as
demonstrat... | Comparative Study of Epigastric Pain Syndrome and Postprandial Distress Syndrome | NCT00673972 | Contradiction |
1,532 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Eligible patients will include anyone >18 years old that presents to the participating
clinical institutions and requires an endosonographic evaluation for the presence of a
solid-appearing mass lesion amenable to EUS access, and no contraindication to FNA as
... | Beacon BNX™ Endoscopic Ultrasound (EUS)-Needle vs SharkCore™ Needle | NCT02872831 | Contradiction |
6,815 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients of participating Hemophilia Treatment Centres with Hemophilia A or B
Exclusion Criteria:
- none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| World Bleeding Disorders Registry | NCT03327779 | Entailment |
6,552 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- 12 to 65 years old;
- The activity of the coagulation factor VIII (FVIII:C) ≤5%, and was previously treated
with FVIII concentrate(s) for a minimum of 50 exposure days (EDs) prior to study entry
- Bleeding state need to be treated with FVIII;
... | Efficacy and Safety Study of SCT800 for On-demand Treatment With in Patients With Hemophilia A | NCT02921945 | Contradiction |
793 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Age between 18 and 75 years old.
2. Patients with clinically verified OA, coming to see a physical therapist for the
Supported self-management of osteoarthritis program.
Exclusion Criteria:
1. Other serious disorders causing hip or knee pain ... | The Effect of Structured Information and Individually Adapted Exercise on Levels of Physical Activity Measured by Accelerometer in Patients With Knee or Hip Osteoarthritis | NCT02022566 | Entailment |
2,227 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
1. In the opinion of the investigator, the participant is capable of understanding and
complying with protocol requirements.
2. The participant or, when applicable, the participant's legally acceptable
representative signs and dates a written, informed... | Efficacy and Safety of Extended Release and Immediate Release Febuxostat in Participants With Gout | NCT02139046 | Entailment |
3,148 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
Group 1: Interstitial Lung Disease and Other Parenchymal Lung Diseases
- Known or suspected interstitial lung disease regardless of radiographic pattern
- Interstitial lung disease due to alternative autoimmune etiology
- Sarcoidosis
- Organiz... | Sjogren's Lung Study | NCT04843345 | Contradiction |
4,310 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | - INCLUSION CRITERIA:
1. Age greater than or equal to 18 years and less than or equal to 60 years
2. Body mass index (BMI) of 19-32 kg/m(2)
3. Estimated glomerular filtration rate greater than or equal to 70 mL/min at
screening, calculated using the CKD... | Safety, Tolerability, and Pharmacokinetics of SAB-301 in Healthy Adults | NCT02788188 | Entailment |
5,710 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- obese or overweight 4th grade public school student in Starkville
Exclusion Criteria:
- unable to run or physical disease or disability
Female
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 12 Years | Nutrition and Soccer for Pediatric Overweight and Obesity | NCT00365651 | Entailment |
7,006 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
Group 1: Cognitively Normal (CN)
1. No subjective complaints of cognitive impairment
2. No cognitive impairment evident on formal testing interpreted by expert adjudication
committee (typically, performance not worse than 1 SD below demographically relevan... | Wake Forest Alzheimer's Disease Clinical Core | NCT03140865 | Entailment |
5,175 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. Women, 50 to 80 years of age, both inclusive.
2. Body weight between 40.0 and 99.9 kg, both inclusive, when rounded to the nearest
tenth.
3. Postmenopausal
4. Bone mineral density T-score ≤ - 2.5 and ≥ - 4.0 at the lumbar spine (L1 to L4) a... | A Phase 3 Study to Compare Efficacy, Pharmacokinetics, Pharmacodynamics, and Safety of CT-P41 and US-licensed Prolia in Postmenopausal Women With Osteoporosis | NCT04757376 | Entailment |
5,880 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patients newly diagnosed as erosive esophagitis or history of erosive esophagitis
confirmed by endoscopy.
- Patients who answered questionnaires of quality of life (QOLRAD-J), symptom severity
and frequency and treatment satisfaction.
- ... | Omepral® Tablets Special Clinical Experience Investigation in Patients With Erosive Esophagitis | NCT00859287 | Contradiction |
5,828 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Diagnosis and main criteria for inclusion:
- Subjects diagnosed with GERD with symptomatic improvement on PPIs.
- Subjects who have demonstrated a baseline 24 Hour pH ≥ 4% time with pH ≤ 4.0.
- Subjects with a baseline GERD-HRQL heartburn score of ≤11 on PPI and ≥ 20 off PPI.
... | An Evaluation of the Medtronic Gatekeeper System in the Treatment of SUBJECTS With Gastroesophageal Reflux Disease (GERD) | NCT00200044 | Contradiction |
2,695 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- patients with inguinal hernia
Exclusion Criteria:
- patients with malignancies
No condition on gender to be admitted to the trial.
Subject must be at least 18 Years old.
| Inguinal Hernia and Arterial Disease | NCT04428138 | Entailment |
3,432 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion criteria:
- Hyperlipidemic
- On therapy for hyperlipidemia for >=3 months without achieving target lipid values
Exclusion criteria:
- Hypersensitivity or intolerance to hypolipemics
- Significant myopathy or rhabdomiolysis probably caused by hypolipemic... | Study of Lipid Control in Hyperlipidemic Participants (MK-0653-179) | NCT01436253 | Entailment |
455 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. PCOS diagnosed by Roterdam criteria
2. Protocol used for ovulation induction either long procol with freeze all embryos vs
antagonist with fresh embryo transfer
3. BMI less than 30
4. ALL patients receiving adjuvant drugs for prevention of ... | Long Protocol and Freeze All Embryos vs Antagonist Protocol With Fresh Embryo Transfer in PCOS Patients Undergoing ICSI | NCT03118830 | Contradiction |
2,293 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- no major complaints of muscle numbness, spasm, or atrophy, muscle-related physical
activity impairment or joint swelling and pain
- no obvious malformation in the lower limbs
- no disease history in the musculoskeletal system, nervous system, and pe... | A New Method of Muscle Strength Testing Using a Quantitative Ultrasonic Technique and a Convolutional Neural Network | NCT04043832 | Contradiction |
1,461 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- adults age 18 years and older with essential hypertension.
- who are treated with medication to lower their blood pressure.
- whose mean daytime blood pressure at enrolment is 135/85 mm Hg or greater.
- and who are not currently using HBPM.
... | Home Blood Pressure Monitoring and Blood Pressure Control | NCT00202137 | Entailment |
4,920 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria for PD:
- Diagnosis of idiopathic Parkinson's disease where the diagnosis was made by a Movement
Disorder Specialist according to the MDS criteria of 2015, with a Hoehn and Yahr scale
(H&Y) of at least 2 (bilateral involvement).
- Onset of the symptom... | Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders | NCT04725045 | Entailment |
6,385 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Are currently not hospitalized
- Have one or more mild or moderate COVID-19 symptoms: Fever, cough, sore throat,
malaise, headache, muscle pain, gastrointestinal symptoms, or shortness of breath with
exertion
- Must have sample taken fo... | A Study of Immune System Proteins in Participants With Mild to Moderate COVID-19 Illness | NCT04634409 | Entailment |
5,728 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion criteria
- women age >18 years
- diagnosed with LD (VLS or LP histologically proven)
- Clinical LS score ≥ 4 based on the score of Günthert et al. [1]
- Normal Pap-smear within 24 months
- negative clinical and microscopic evaluation of vaginal fluid... | Laser Therapy in Women With Lichenoid Disorders | NCT04697563 | Contradiction |
2,464 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- sarcoidosis, subjects (18 - 45 years of age), including 30 sarcoidosis, 15 latent TB
and 15 healthy controls.
Exclusion Criteria:
- pregnant women
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 1... | Development of a Novel Human In Vitro Sarcoidosis Model | NCT01857401 | Entailment |
2,277 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. Completed Study NS-065/NCNP-01-201 through Week 25.
2. Willing and able to comply with scheduled visits, investigational product
administration plan, and study procedures.
3. Stable dose of glucocorticoid (GC), and is expected to remain on the stable ... | Extension Study of NS-065/NCNP-01 in Boys With Duchenne Muscular Dystrophy (DMD) | NCT03167255 | Contradiction |
5,310 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
In osteoporotic patients:
- 50-80 years of age
- Established diagnosis of osteoporosis, based on prior dual energy x-ray absorptiometry
(DXA) scan with T-score <-2.0 at any site and/or history of fragility fracture
In healthy controls:
... | Radio-frequency Identification (RFID) Osteoporosis Pilot Study | NCT03385941 | Entailment |
2,947 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Sporadic ALS diagnosed as possible, laboratory-supported probable, probable, or
definite ALS as defined by revised El Escorial criteria.
2. Age 18 years or older.
3. Symptom onset of weakness or spasticity due to ALS ≤ 60 months prior to Screening
... | Mexiletine in Sporadic Amyotrophic Lateral Sclerosis | NCT02781454 | Entailment |
6,691 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Adults or adolescents older than 12 years
- Patients under Prophylactic treatment with Advate® for at least 1 year
- Written informed consent.
Exclusion Criteria:
- History of FVIII inhibitor (titre ≥ 0.6 BU [Bethesda unit]) or detectable FV... | Personalized Prophylactic Treatment With Advate® in Severe or Moderate Haemophilia A Patients | NCT02622646 | Contradiction |
1,370 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Hirschsprungs disease confirmed preoperative and postoperative specimen pathology
Exclusion Criteria:
- Other cases of Enterocolitis and constipation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months ol... | Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated Enterocolitis | NCT02343562 | Contradiction |
1,922 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
Main inclusion criteria :
- Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain), or
dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).
- Need of upper GI endoscopy and pH monitoring.
- Normal pr... | Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux | NCT00231881 | Entailment |
32 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Males with age 35-75 years inclusive.
- Evidence of hypogonadism: Hypogonadism will be defined as low total testosterone (<300
ng/dL) and low calculated free testosterone (below 6.5ng/dL; calculated using
testosterone and SHBG). Testosterone levels... | Effect of Androgel on Total and Regional Adipose Tissue and Lean Body Mass in Type 2 Diabetic Patients With Hypogonadism | NCT00440440 | Contradiction |
1,198 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Subject provides informed consent
- Subject is >18 years of age
- Subject is deemed competent for making medical decisions
- Subject is scheduled to undergo radiation followed by extrapleural pneumonectomy.
- Subject is a surgical candida... | Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma | NCT02613299 | Entailment |
4,614 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Healthy, nonpregnant women with regular menstrual cycles
- sexually active and at risk of pregnancy
- acceptable body mass index (BMI)
- last term pregnancy at least 42 days prior, nonlactating, with 1 normal menstrual
cycle since
... | A Study of Efficacy and Safety With the Transdermal Contraceptive System Versus Triphasil. | NCT00236795 | Entailment |
5,161 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Confirmed diagnosis of osteoporosis or osteopenia examination of bone densitometry;
- Patients without severe neurological disease, vascular disorders, labyrinthitis and
blindness;
- No use of gait auxiliaries;
- No history of fractures ... | Immediate Effect Of Whole-Body Vibration And Walk in Osteoporosis/Osteopenia | NCT03448276 | Contradiction |
733 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Radiographic evidence of at least moderate narrowing (joint space < 1mm) or the
presence of osteophytes or sclerosis at the Carpometacarpal joint
- Patient complaint of unacceptable pain despite modification of activity, a trial of
splinting and a ... | An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study | NCT00198029 | Contradiction |
2,395 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | - INCLUSION CRITERIA:
DMD Subjects
- Eligible for the parent study
- Willing and able to comply with all protocol requirements and procedures, including
MRI without sedation
- Able to give informed assent and parent(s)/legal guardian to give informed consent in... | Studying Skeletal Muscle, Heart, and Diaphragm Imaging in Boys With Duchenne Muscular Dystrophy | NCT01451281 | Entailment |
5,181 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
Postmenopausal women aged ≥50 years (Menopause was defined as the absence of menstrual
cycles for at least one year)
Exclusion Criteria:
Morphological abnormalities or skeletal distortions
Female
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
| Height Loss, Kyphosis Indicators, Bone Mineral Density and Vertebral Fractures in Chinese Postmenopausal Women | NCT03798444 | Entailment |
6,805 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- subject of Hemophilia
- 20-65 years old
Exclusion Criteria:
- Any history of surgery
Male
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 65 Years | The Effect of Functional Activities and Balance Ability With Taping in Subjects of Hemophilia | NCT02389205 | Entailment |
6,185 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Age equal or more than 18;
- Symptoms suggestive of Covid-19 pneumonia. At least : fever > 38°C or influenza-like
illness (asthenia, myalgia, chills, muscular aches, …) AND cough or dyspnea;
- Hospitalization required on clinical criteria including:... | Renin-Angiotensin-Aldosterone System Inhibitors, Hypertension, and COVID-19 | NCT04374695 | Contradiction |
4,065 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- medical diagnosis of Grade 3 or 4 knee OA
- have a prescribed knee brace for at least three months
- self-reported knee pain when standing, walking, climbing stairs, squatting, or other
mobility activities
- self-reported limitations to ... | A Powered Exoskeleton for Veterans With Knee OA | NCT04653896 | Entailment |
4,235 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Ages 18 or older
- Self-report of general good health other than voice disorder
- Self-report of normal pulmonary function
- Non-smoker status for at least the last 5 years
- English as their primary language to avoid potential linguistic... | The Effects of Respiratory Training on Voice | NCT04710862 | Contradiction |
3,792 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Signature of the free, informed consent form
- Age over 18 years old
- Knee pain for more than six months without improvement with clinical treatment
- Clinical and imaging diagnosis (radiography) of knee osteoarthritis
- Moderate pain in... | Ultrasound-guided Genicular Nerve Block With Phenol for the Treatment of Chronic Pain Due to Knee Osteoarthritis | NCT03601533 | Entailment |
5,580 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Previously randomized in study B9R-US-GDFG (NCT00406926)
- Karyotype-proven Turner syndrome
Exclusion Criteria:
- Immediate family members of study site personnel directly affiliated with the study
Female
No healthy subjects accepted to join the trial.
... | Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome | NCT00266656 | Contradiction |
5,328 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- 12 to 65 years old;
- The activity of the coagulation factor VIII (FVIII:C) ≤2%, and was previously treated
with FVIII concentrate(s) for a minimum of 50 exposure days (EDs) prior to study entry
- Non-bleeding state (No clinical manifestations of ac... | Pharmacokinetic Study of SCT800 in Previously Treated Patients With Hemophilia A | NCT02888223 | Contradiction |
47 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Women age 18-55
- Hypopituitarism with central adrenal and/or gonadal deficiencies. To qualify patients
will need to have either 1 or 2 and they need to have 3:
1. To diagnose central adrenal deficiency, patients not on glucocorticoid
... | Testosterone Gel Applied to Women With Pituitary Gland Problems | NCT00144391 | Contradiction |
1,754 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients must have cytologically or pathologically verified diagnosis of gastric
cancer; patients must have locally advanced or distant metastatic disease (either
recurrent or at primary diagnosis) that is not surgically curable
- The patholog... | S0413 Lapatinib in Treating Patients With Locally Advanced or Metastatic Stomach Cancer | NCT00103324 | Contradiction |
5,957 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Female subject is not pregnant or lactating, Females of childbearing potential must
use reliable means of contraception during the course of the study
- Subject is in good health
- Subject is able to abstain from smoking during the 24-hour periods b... | A Study to Assess the Bioequivalence of Famotidine/Antacid Combination Tablets Compared to Famotidine/Antacid EZ Chew Tablets (0208C-145)(COMPLETED) | NCT00944671 | Contradiction |
6,225 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Age >18 years.
- Fever ≥ 38º C with upper respiratory tract manifestations, generalized bone ache with
or without gastrointestinal symptoms as diarrhea.
- Chest CT with signs suggestive of COVID-19.
- Mild and moderate cases of COVID-19 ... | The Role of Sodium Bicarbonate as Adjuvant Treatment of Computed Tomography Identified COVID-19 Pneumonia | NCT04374591 | Contradiction |
5,155 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Experimental group:
Inclusion Criteria:
- patients with the diagnosis including lumbar spondylosis, low back pain, osteoporosis,
compression fracture, back pain treated at National Taiwan University Hospital
- received rehabilitation at the Physical Therapy Center in recent... | Physical Therapy Management in Degenerative Lumbar Diseases and Osteoporosis | NCT01703403 | Contradiction |
3,681 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
Patient group
- Radiating leg pain due to nerve root compression verified by MRI
- Clinical findings in accordance with MRI findings
- Average leg pain ≥ 3/10 on a numeric pain rating scale Controls
- No current or previous history of ongoing ... | Changes in Radicular Pain and Pain Modulation | NCT04193969 | Entailment |
6,511 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Participants with severe hemophilia A (baseline FVIII activity FVIII:C <1%),
determined by measurement at the time of screening (following a washout period of at
least 72 h after their last FVIII treatment for standard half-life FVIII products or
... | Study to Compare How the Body Distributes and Excretes the Drugs Jivi (BAY 94-9027) and Adynovi in Patients With Severe Hemophilia A (Bleeding Disorder Resulting From a Lack of Blood Clotting Factor VIII) | NCT04015492 | Contradiction |
2,186 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Male or female, aged 18 to 80
- Severe gout, demonstrated by 3 or more gout flares in the previous 12 months, or the
presence of at least one gout tophus or gouty arthritis
- Hyperuricemia with a sUA ≥8.0 mg/dL
Exclusion Criteria:
... | Tranilast Plus Allopurinol in Patients With Moderate to Severe Gout (TAnGO) | NCT01109121 | Contradiction |
1,597 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Signed informed consent form and participated in all stages of the study
- Being in the age range of 18-25
- Being right-handed
Exclusion Criteria:
- Having physical, mental disability (vision, hearing, etc.) which may affect
pa... | Effect of Kinesiotaping on Wrist Kinematics and Functional Performance | NCT03788954 | Contradiction |
683 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
1. HFE C282Y homozygous.
2. Aged 18 - 70 years .
3. SF above the upper limit of the normal range of 300µg/L but less than 1000µg/L with a
currently or previously raised TS (>greater than the upper limit of normal for the
testing laboratory).... | Mi-iron - Moderately Increased Iron - is Reducing Iron Overload Necessary? | NCT01631708 | Entailment |
3,293 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- alteration of the foveal contour not classifiable as lamellar or pseudo macular hole
- focal, well-defined increased autofluorescence signal at the fovea
Exclusion Criteria:
- intraretinal cysts not associated with break of the inner retina
-... | Simultaneous OCT and B-FAF in Eyes With Alteration of the Foveal Contour | NCT03287648 | Contradiction |
2,658 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- 18 years of age or older (19 years in Nebraska)
- Male
- Diagnosis of inguinal hernia (patients with bilateral and recurrent hernias are
eligible)
- Inguinal hernia that is either completely asymptomatic or minimally symptomatic (does
... | Inguinal Hernia Management: Watchful Waiting vs. Tension-Free Open Repair | NCT01922674 | Entailment |
1,487 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Mean screening systolic blood pressure of 110 to < 160 mm Hg at most recent visit
- Mean screening diastolic blood pressure of 70 to <100 mm Hg at most recent visit
Exclusion Criteria:
- Currently taking antihypertensive medications
- Known ... | Evaluating Novel Approaches for Estimating Awake and Sleep Blood Pressure | NCT04307004 | Entailment |
4,161 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Male or female healthy volunteers, 18 to 55 years of age, inclusive. A female
participant is eligible to participate if she is of non-childbearing potential defined
as postmenopausal or surgically sterile
- Healthy status is defined by absence of e... | A Single Center Study to Evaluate the Penetration of RO7033877 Into the Lung in Healthy Volunteers | NCT02165293 | Contradiction |
5,401 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women with menorrhagia
- 18-49 years of age
- Regularly occuring menstrual periods
Exclusion Criteria:
- History or presence of clinically significant disease or abnormalities that might
confound the study
- History ... | Safety Study of XP12B in Women With Menorrhagia | NCT00113568 | Entailment |
2,182 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Self-reported doctor-diagnosed arthritis
- No physical limitations precluding exercise participation
- Negative screen for CVD (PAR-Q)
- Age 20+
- English or Spanish speaking
Exclusion Criteria:
- Presence of any cond... | Fitness and Exercise for People With Arthritis | NCT00252070 | Contradiction |
221 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
men with
- hypergonadotropic hypogonadism
- hypogonadotropic hypogonadism
- late-onset hypogonadism
combined with an initial Testosterone serum level of < 11 nmol/l
Exclusion Criteria:
- known or suspected carcinoma of the pr... | Three-Year Trial on a New Testosterone Gel | NCT00204269 | Entailment |
101 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male
- 18 years to 65 years
- Low testosterone as defined by criteria (serum total testosterone <350 ng/dl in men
<55 years, <300 ng/dl in men 55-65 years)
- EITHER taking opioid pain medication (see A below) OR planning to start new pai... | Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration | NCT01880086 | Contradiction |
6,970 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Diagnosis of Alzheimer's type dementia, rated as severe
- progressive worsening of memory and other cognitive functions
- brain imaging (CTor MRI scan) within last 3 years
- ability to be mobile (aided or unaided) with sufficient vision and hearing t... | Treatment of Severe Alzheimer's Disease: Evaluation of Efficacy and Safety of Galantamine Hydrobromide in a Controlled Study | NCT00216593 | Entailment |
12 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Women age 18-55
- Hypopituitarism with central adrenal and/or gonadal deficiencies. To qualify patients
will need to have either 1 or 2 and they need to have 3:
1. To diagnose central adrenal deficiency, patients not on glucocorticoid
... | Physiologic Testosterone Replacement in Women With Hypopituitarism | NCT00144391 | Contradiction |
2,197 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Age > 18 years
- Mono or oligo arthritis (2-3 swollen joints)
- Indication for diagnostic aspiration of an inflamed joint in which gout is one of the
possibilities
Exclusion Criteria:
- Polyarthritis ( up to 4 swollen joint);
... | Diagnostic Value of DECT Scan Compared to Diagnostic Needle Aspiration | NCT03038386 | Contradiction |
3,725 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Phase I
Inclusion Criteria:
• All current or retired professional male footballers (Registered with the Professional
Footballer Association (age range 40 -80)
Phase II
Inclusion Criteria:
- Professional footballers both with and without a history of knee pain knee... | Knee Osteoarthritis Risk in Retired Professional Footballers | NCT02098044 | Contradiction |
3,823 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients with osteoarthritis of the hip or knee who use current approved medication
(nonsteroidal anti-inflammatory drugs (NSAIDs)) or tylenol to treat the symptoms of
their osteoarthritis. Patients taking NSAIDs are required to discontinue using these
... | An Investigational Drug in Patients With Osteoarthritis (0663-073) | NCT00092755 | Entailment |
1,388 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Clinical diagnosis of Hirschsprung Disease
Exclusion Criteria:
- with other disease
- receive emergency surgery
- need to do the ostomy
- full colonic Hirschsprung Disease
No condition on gender to be admitted to the trial.
No he... | Enhanced Recovery After Surgery In Hirschsprung Disease | NCT02776176 | Entailment |
2,091 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Diagnosis of IPF
- Ability ot provide informed consent
Exclusion Criteria:
- History of fundoplication or other gastroesophageal surgery
- Too ill to undergo bronchoscopy in the opinion of the investigator
No condition on gender to be admitt... | Microaspiration in Pulmonary Fibrosis | NCT01150591 | Entailment |
1,224 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Age > 18 years
2. Symptomatic pleural effusion requiring intervention
3. Expected survival > 3 months
4. Written informed consent to trial participation
Exclusion Criteria:
1. Females who are pregnant or lactating
2. Inabi... | Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical Pleurodesis | NCT04806373 | Entailment |
2,821 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- age between 18 and 75 years
- diagnosis of ALS according to revised El Escorial criteria and Awaji-Shima criteria
- disease duration < 24 months
- ALSFRS-R > 30 at the recruitment
- ALSFRS-R decline > 1 in the at least 3-months period bef... | Transcranial Static Magnetic Field Stimulation (tSMS) in Amyotrophic Lateral Sclerosis (ALS). | NCT04393467 | Entailment |
6,557 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Have given their agreement to take part in the observational registry after being
informed in writing of the purposes of the study and after their data have been
recorded (parent's agreement for minor patients);
- Be suffering from haemophilia A an... | Register of Patients With haEmophilia A tReated With Afstyla® | NCT04675541 | Contradiction |
2,954 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- patients over 18 years old
- ALS sporadic or familial or unknown
Exclusion Criteria:
- known cutaneous disease not allowing the biopsy
- platelets less than 10 000/m3
- suspected or known xylocain allergy
No condition on gender t... | Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study | NCT01639391 | Entailment |
338 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Woman of more than 18 years, presenting vulvo-vaginal symptoms to type(chap) of smell
or abnormal vaginal losses the day of the inclusion and having an imbalance of the
vaginal flora objectivized by:
- The presence of at least 3 clinical criteria o... | The Value of Bacterial Loads by Real Time PCR in Predicting Recurrence of Abnormal Vaginal Flora After Oral Metronidazole Therapy | NCT01287728 | Contradiction |
3,458 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion criteria
1. Diagnosis of type 2 diabetes mellitus.
2. Current treatment with metformin alone (>/= 1500 mg or maximally tolerated dose) or
metformin plus 1 other antidiabetic drug. Metformin must be administered in twice
daily dosing regimen. Patients taking metf... | Linagliptin 2.5 mg Twice Daily Versus 5 mg Once Daily as add-on Therapy to Twice Daily Metformin in Type 2 Diabetes | NCT01012037 | Entailment |
5,634 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | - INCLUSION CRITERIA:
- Girls without a chronic medical condition
- Normal weight (BMI 5th-85th%) or overweight/obese (BMI > 85th%)
- 8-14 years old
- Some breast development
- Pre-menarchal
EXCLUSION CRITERIA:
- Treated with medications ... | Investigating the Impact of Obesity on Pubertal Development in Girls | NCT02583646 | Contradiction |
4,178 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Subjects ≥ 18 years of age.
- Signature of the written informed consent
Exclusion Criteria:
Subjects will be excluded if they meet at least one of the following conditions:
- Abnormal spirometry defined as FEV1, FEV1/VC and VC below the LLN as ... | Within-Breath Total Respiratory Input Impedance in Healthy Adult Subjects | NCT04140825 | Contradiction |
4,726 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Confirmed adenomyosis and/or endometriosis
- Signed an approved informed consents
- Feasible for biopsy
Exclusion Criteria:
- Not meeting all of the inclusion criteria
Female
No healthy subjects accepted to join the trial.
Subject must be at... | A Multi-omics Study of Adenomyosis | NCT03742843 | Entailment |
6,562 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Eligibility criteria for person with congenital bleeding disorder(PWCBD, men with
congenital hemophilia):
- Known diagnosis of congenital hemophilia A or B with or without inhibitor (defined by
a plasma factor VIII or factor IX level below lower limits of normal and medical
... | Socialization of Adult Men With Congenital Hemophilia A or B | NCT01510418 | Contradiction |
605 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Patients with unexplained RPL.
- Patients with abnormal immunological profile, including ANA, RF, anti-DNA,
antilymphocyte, anticardiolipin, antithyroid and lupus anticoagulant antibodies that
have no other clinical manifestation.
- Wom... | Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss | NCT04558268 | Entailment |
6,115 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Healthy persons aged ≥ 18, and able to give informed consent
- Patient is admitted to hospital
- Primary reason for hospital admission is clinical suspicion of a new episode of ARI
- Onset of the following symptoms within the last 7 days: i. Sudden o... | Predicting Severity and Disease Progression in Influenza-like Illness (Including COVID-19) | NCT04664075 | Contradiction |
444 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women with PCOS aged 20-30 years and 40-49 years. Subject is considered to have PCOS
if she has current or verifiable history of: a) clinical and/or biochemical evidence
of hyperandrogenism plus b) oligomenorrhea (average menstrual cycle length >45 days or
... | Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS | NCT03905603 | Contradiction |
936 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patients > 18 years with diagnosis of OA or RA according to the criteria of the
American College of Rheumatology (ACR).
Exclusion Criteria:
- Patients with precedents of fractures; carrying patients of chronic diseases who limit
them in th... | Mexican Initiative of Patients With Osteoarthritis and Rheumatoid Arthritis (IMPACTAR) | NCT02124031 | Entailment |
5,772 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
1. Clinically and histopathologically proven cases of erosive and atrophic OLP.
2. Patients who are willing to participate in the study.
Exclusion Criteria:
1. Patients with reticular form of OLP and OLP with muco-cutaneous involvement.
2. Patient... | Effect of Oral Zinc Supplementation as an Adjuvant to Topical Corticosteroid in Oral Lichen Planus Patients | NCT04278599 | Contradiction |
528 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria for women:
- Age 18-50 years old
- Regular menses
- HIV-1 seronegative at screening
- Normal Pap smear at screening or documented normal Pap smear within six months prior
to screening
- No evidence of reproductive tract infectio... | Safety Study of UC-781 Vaginal Microbicide | NCT00446979 | Contradiction |
2,306 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Ages 2-17 years old with a confirmed diagnosis of DMD. Has an appointment in MDA
clinic at the Ann & Robert H. Lurie Children's Hospital of Chicago.
Exclusion Criteria:
- Is less than two years old and does not have a confirmed diagnosis of DMD.
Male
... | Aerobic Exercise in Boys With Duchenne Muscular Dystrophy (DMD) | NCT03319030 | Entailment |
4,572 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Healthy women
- Regular menstrual cycles (23 -35 days cycle length)
- No systemic or intrauterine steroid hormone use
Exclusion Criteria:
- Psychiatric disorder (DSM IV Axis I or WHO ICD-10 diagnostic classification).
- Prior or ... | Neuropsychobiological Correlates of Sex-steroid Hormone Manipulation in Healthy Women: a Risk Model for Depression | NCT02661789 | Contradiction |
5,318 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
1. Pregnant females >= 18 years of age
2. Confirmed VWD, as defined by VWF:RCo < 0.50 IU/dL and previous history of bleeding
3. Willingness to have blood drawn
4. Willing to be randomized to one of two treatments at delivery and for 2 days
pos... | Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial | NCT04344860 | Contradiction |
1,654 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Males and Females who meet the inclusion/exclusion criteria; females must not be
pregnant or nursing, and must agree to use a double-barrier method of birth control
(condoms or diaphragm, plus spermicide) throughout the trial (alone or in addition to
... | Pharmacokinetic Interaction Between TRUVADA™ and BILR 355 BS Plus Ritonavir in Healthy Volunteers | NCT02253901 | Entailment |
1,004 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion criteria:
- Diagnosis of primary knee osteoarthritis, based upon the following:
- X-ray or Magnetic Resonance Imaging (MRI) evidence within the last 6 months for joint
space narrowing and osteophyte formation
- Patients will be Kellgren and Lawrence classification... | Safety of Single Doses of SAR113945 and Efficacy and Safety of a New Formulation Given Into the Knee in Osteoarthritis Patients / Part I | NCT01463488 | Entailment |
2,885 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Diagnosis of definite or possible ALS by the El Escorial Criteria
- No previously known gastrointestinal problems
Exclusion Criteria:
- Patients or controls who have evidence of previous gastrointestinal disease
- Patients unable to give inf... | Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS) | NCT00714220 | Entailment |
667 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- All adult patients (age 19 or greater) with hereditary anemias requiring chronic blood
transfusion at St. Paul's Hospital will be invited to participate in this study. The
majority of patients will be β-Thalassemia Major.
Exclusion Criteria:
... | Utility of Fibroscan in Estimating Hepatic Iron Concentration | NCT02067130 | Contradiction |
373 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | - ELIGIBILITY CRITERIA:
- Females, age 15-44.
- Since bacterial vaginosis is primarily a condition of reproductive-age women, this
study will be restricted to women regarded by demographers as reproductive age.
- Non-pregnant women whose last menstrual period is later t... | Longitudinal Study of Vaginal Flora | NCT00340275 | Contradiction |
1,180 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- recurrent symptomatic malignant pleural effusion, with subjective improvement of
dyspnea following thoracentesis
Exclusion Criteria:
- history of any allergy to iodine or doxycycline
- history of thyroid disorders
- failure of l... | A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion | NCT02583282 | Entailment |
1,018 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Men/Women aged over 20
- Subjects who are diagnosed with one- or both-sided knee osteoarthritis according to
the standards of clinical diagnosis from American College of Rheumatology(ACR)have
knee osteoarthritis pain and meet over three of the foll... | Clinical Trial of YYC301 for Treatment of Osteoarthritis of the Knee | NCT03850587 | Entailment |
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