id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
values | statement_pol stringclasses 50
values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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4,919 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Must be ≥22 and ≤80 years of age
- Competent and willing to provide written, informed consent to participate in the study
- A diagnosis of essential tremor as confirmed from clinical history and examination by
a movement disorder neurologist
... | A Pilot Study of the Cala ONE Device for Essential Tremor | NCT03152136 | Entailment |
4,605 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
Patients:
• Patients ≥5 years of age undergoing surgery at Mbale Regional Referral Hospital, who
receive post-operative care in one of four main surgical wards, with a family carer
prepared to participate in the trial intervention.
Carers:
- All... | Family SuppleMented pAtient monitoRing afTEr suRgery: A Pilot Trial | NCT04341558 | Entailment |
4,357 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Has had an oculo-visual examination in the last two years
- Is at least 18 years of age and has full legal capacity to volunteer
- Has read and understood the information consent letter
- Is willing and able to follow instructions and maintain the ap... | Multicenter Dispensing Study of Biofinity Lenses in Extended Range | NCT02060539 | Entailment |
460 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Each subject must be willing and able to provide written informed consent for the
study.
- Each subject must be female with years of age ≥35 to ≤42 at the time of recruitment..
- Each subject must have an indication for controlled ovarian stimulatio... | Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients | NCT02466204 | Contradiction |
6,173 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Age 18 years or older
- Negative RT-PCR test at the beginning of the study.
- Negative SARS-CoV-2 serological Elecsys Anti-Sars-CoV-2 test at the beginning of the
study.
- Living in a geographic area with active COVID-19 transmission (nu... | Effectiveness and Adherence to Closed Face Shields to Prevent COVID-19 Transmission | NCT04647305 | Contradiction |
2,581 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- unilateral inguinal hernia
- age between 2 years and 17 years
- no history of abdominal or inguinal operations
- the age range was based on the day surgery criteria of our hospital
- of male patients, only those with completely descended ... | Laparoscopic Hernia Repair With Lateral Umbilicus Ligament for Children | NCT01377181 | Contradiction |
2,299 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. Diagnosed with one of four specific muscle diseases on the basis of diagnostic
criteria:
1. Limb girdle muscular dystrophy; symptomatic limb girdle muscular dystrophy
genetically or pathologically proven
2. Dystrophinopathi... | Acceptance and Commitment Therapy for Muscle Disease | NCT02810028 | Contradiction |
4,881 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | PROTOCOL ENTRY CRITERIA:
Suspected adrenocorticotropin hormone (ACTH)-dependent Cushing's syndrome No pregnant women
Effective contraception required of fertile women
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
| Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome | NCT00004343 | Entailment |
6,644 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male subjects
- Any ethnicity
- Age <6 years
- Severe haemophilia A (FVIII:C <1%), as confirmed at enrolment by the central
laboratory.
o Those patients diagnosed locally as severe but subsequently found to have FVIII
... | Survey of Inhibitors in Plasma-Product Exposed Toddlers | NCT01064284 | Contradiction |
1,000 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
To be included in the study, participants needed to suffer knee osteoarthritis with
osteoarthritis levels 2 - 4 according to Kellgren-Lawrence grade12, be aged between 50 and
75 years and suffer knee pain and functional disability for at least three months,
according... | Ultrasound and Exercises in Knee Osteoarthritis | NCT03676790 | Entailment |
1,797 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients who present to the KCVA GI endoscopy unit with symptoms of reflux,upper
abdominal pain, anemia (patients referred by their primary care physicians with a
diagnosis of low hemoglobin (< 10 G/DL, and or dyspepsia
Exclusion Criteria:
... | Demographics and Findings of Upper Endoscopy Patients | NCT00576992 | Contradiction |
4,136 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- the patient was admitted to a general department of Rambam Medical Center for any
reason from March to May 2008
- the patient is 65 years old or older
- the patient is in a good health, based on medical history, physical examination and
... | Interventional Trial of Vitamin D Deficiency in the Patients of General Departments | NCT00640237 | Contradiction |
4,918 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Age: 20-80 years
- Patients with tremor (involuntary, rhythmic, oscillatory movement in one or more body
part)
- Subject who signed an informed consent
Exclusion Criteria:
- Pregnant or nursing woman.
- Comorbid neur... | Assessment of Tremor Using SNUMAP Motion Sensing System | NCT01731145 | Entailment |
550 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
Patients with poor ovarian response (POR) diagnosis according to the POSEIDON
stratification system (as POSEIDON group 1) with following criteria :
- Women' age under 35 years;
- Previous unexpected poor or suboptimal ovarian response after using conventional... | The Effect of Dual Trigger for Final Oocyte Maturation on IVF/ICSI Outcomes in Patients With Suboptimal Ovarian Response | NCT04549649 | Contradiction |
5,143 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal women (natural or surgically induced menopause)
- Low bone mineral density (BMD), as defined by a T score or equivalent BMD absolute
value (g/cm2) for lumbar spine of between -2.0 and -3.5, inclusive
- Body mass index (BMI) must be wi... | Safety and Efficacy of Multiple Dosing Regimens of BPS804 in Post Menopausal Women With Low Bone Mineral Density | NCT01406548 | Contradiction |
1,232 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed malignant pleural effusion (MPE)
- Symptomatic disease
- Candidate for thoracoscopic surgery for treatment of MPE
- No known or suspected ipsilateral pleurodesis that would preclude surgery
... | Surgery and Intrapleural Docetaxel in Treating Patients With Malignant Pleural Effusion | NCT00114205 | Entailment |
6,981 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Diagnosis of probable AD based upon the National Institute on Aging-Alzheimer's
Association (NIA-AA) Criteria
- MMSE Score 12-24 inclusive
- Modified Hachinski Ischemia Scale (MHIS) score of ≤ 4
- Provided a signed and dated informed con... | A Randomized Study to Assess the Safety of GRF6019 Infusions in Subjects With Mild to Moderate Alzheimer's Disease | NCT03520998 | Entailment |
3,297 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- children aged from 7-12 years old;
- children with spherical equivalent ranged from -0.5D to -6.0D;
- children without other eye diseases except for ametropia
Exclusion Criteria:
- children with other eye diseases: amblyopia, strabismus, eye... | Atropine for Children and Adolescent Myopia Progression Study | NCT03949101 | Contradiction |
1,325 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- All patients who receive easypod GH of age 1-14 years will be approached for consent
to participate in the study. Patients may have any valid cause for short stature.
These may include children with
- isolated growth hormone deficiency
-... | Web-based Adherence Information Integrated Nurse-led Monitoring Clinic | NCT04244123 | Contradiction |
328 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Woman may be on birth control pill (OC), patch or NuvaringTM (vaginal ring) taken in
the traditional 21/7 or 24/4 manner, which means ever month they have a period. If
they are taking it continuously (without a period), you must be willing to take your
... | Prevention of Menstrual Migraines: Using Frovatriptan or Placebo During Hormone Free Intervals | NCT00700128 | Contradiction |
1,141 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Diagnosed HCM
- Documented history of sustained ventricular tachyarrhythmia or resuscitated sudden
cardiac arrest
- Maximal left ventricular wall thickness of > 30mm
- Extensive fibrosis on cardiac MRI (>15% of total myocardial volume)
... | Hypertrophic Cardiomyopathy Pilot Study | NCT02806479 | Entailment |
1,368 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Children between 2 and 16 years and referral to our out patient clinic with either
constipation or fecal incontinence.
- Patients must fulfill the Rome III criteria of constipation, which mean they must have
at least 2 of the following characterist... | Maintenance Treatment for Children With Constipation | NCT01566409 | Contradiction |
5,463 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Healthy adults
- Able to perform their own oral hygiene
- Dental students
Exclusion Criteria:
- Active Dental Caries
- Uncontrolled chronic medical conditions
- History of drug and/or treatment that reduces salivary f... | Efficacy of Miswak in Oral Hygiene Maintenance | NCT04561960 | Entailment |
2,329 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Diagnosis of DMD confirmed by
1. clinical history with features before the age of five
2. physical examination
3. elevated serum creatine kinase level
4. absence of dystrophin expression, as determined by immunostain or We... | Strength Training in Duchenne Muscular Dystrophy | NCT02421523 | Entailment |
615 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Female with a persisting pregnancy of unknown location:
1. A pregnancy of unknown location is defined as a women with a positive pregnancy
test but no definitive signs of pregnancy in the uterus or adnexa on ultrasound
imaging (Ultras... | RCT for Women With a Persisting Pregnancy of Unknown Location | NCT01800162 | Entailment |
4,183 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Age 18-45 years, inclusive, of both genders
2. Negative pregnancy test for females who are not s/p hysterectomy with oophorectomy
3. Forced expiratory volume at one second (FEV1) of at least 75% of predicted (without
use of bronchodilating medications... | A Study of Gamma Tocopherol-enriched Supplement on Lower Airway Responses to Inhaled Wood Smoke in Healthy Adults | NCT03444298 | Contradiction |
5,707 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | PROTOCOL ENTRY CRITERIA:
- Girls aged 8 and 12 years with Turner's syndrome-compatible karyotype
- Age-matched girls without Turner's syndrome entered as controls
- Concurrent registration on Thomas Jefferson University growth study required of
subjects with Turner's syn... | Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome | NCT00004274 | Entailment |
2,817 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Patients with diagnosis of familial or sporadic ALS, defined as meeting the possible,
laboratory-supported probable, probable, or definite criteria for a diagnosis of ALS
according to the revised World Federation of Neurology El Escorial criteria [Rix
... | First Time in Human Study of GSK1223249 in Amyotrophic Lateral Sclerosis | NCT00875446 | Entailment |
5,262 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion criteria :
- Postmenopausal women with menopause duration more than 5 years and with age between
45-75 years old (menopausal age ≥40), or if hysterectomy operated before natural
menopause, the age of women between 60-75 years old.
- Subject with BMD (L2-4 or n... | Efficacy and Safety Study on Menatetrenone in the Treatment of Postmenopausal Osteoporosis Women | NCT00165698 | Entailment |
5,543 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
1. Patients >18 years
2. Diagnosis of large vessel vasculitis based on Ultrasonographic and/or Computed
Tomography Angiography and/or Magnetic Resonance Angiography findings or biopsies of
the temporal arteries
3. Fulfill the classification ... | Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiS | NCT02042092 | Entailment |
213 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
Healthy men:
Good general health,
- Normotensive,
- Normal testosterone levels,
- No medications known to influence glucose homeostasis or testosterone levels
IHH men:
- Good general health;
- Normal thyroid, adre... | Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men | NCT00470990 | Entailment |
3,155 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
To be included in the study, participants needed to suffer knee osteoarthritis with
osteoarthritis levels 2 - 4 according to Kellgren-Lawrence grade12, be aged between 50 and
75 years and suffer knee pain and functional disability for at least three months,
according... | Ultrasound and Exercises in Knee Osteoarthritis | NCT03676790 | Contradiction |
5,239 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Over 50 years of age
- Fragility fracture
- Consulting an orthopedic surgeon at the CHUS for treatment of the fracture
Exclusion Criteria:
- No Primary Care Practitioner
- Severe co-morbidity requiring specialized care
... | Strategies to Treat Osteoporosis Following a Fragility Fracture | NCT00512499 | Entailment |
4,531 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- • Menstrual cycle ranging between 21-42 days
- At least 3 cycles after cessation of breastfeeding
Exclusion Criteria:
- • Not currently on medications that affect ovulation and 3 months prior
- Not currently pregnant or breastfeedi... | Quantum Natural Family Planning Pilot | NCT03908697 | Contradiction |
3,231 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Men and women from 18 to 80 years old
- Patients recruited during the multidisciplinary consultation of Sjogren's Disease,
filling the criteria of Sjogren's Disease or patients having a salivary recidivate
pathology and selected players on the basi... | Evaluation of the Reproducibility Inter-observer of the Ultrasound Anomalies of the Salivary Glands in Sjogren's Disease | NCT02358213 | Entailment |
5,075 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- post-menopausal women
- with a normal Bone Mineral Density (T-score >-1.5) at the 3 sites (lumbar spine, total
hip and femoral neck) or with osteoporosis (T-score ≤ -2.5) at least at one of the 3
sites.
Exclusion Criteria:
- Cu... | Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture | NCT04265742 | Contradiction |
690 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
1. Diagnosis
- Individuals who art homozygous for C282Y or H63D or "compound heterozygous" for
these tow variants and have ferritin levels higher than 300 micrograms/L or
transferrin saturation higher than 50%.
- Indivi... | Erythrocyte Apheresis Versus Phlebotomy in Hemochromatosis | NCT00509652 | Entailment |
4,066 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
To be considered eligible for enrolment into the study, subjects must;
1. Be aged 30 to 75 years (inclusive),
2. Be willing to provide informed consent,
3. Have a BMI between 18.5 and 32 kg/m2,
4. Have documented diagnosis of primary osteoarthriti... | An Intervention Study Evaluating the Effects of a Raspberry Leaf Extract in an Osteoarthritic Population. | NCT03703024 | Entailment |
869 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Age 40-80
- Knee Pain
Exclusion Criteria:
- Inability to read, understand and give effective English consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subje... | Stated-Preferences in Knee Arthroplasty | NCT03058380 | Entailment |
890 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Male or female subjects in the age range of 40 - 70 years (both inclusive).
2. Body mass index (BMI) must be ≥ 25 and < 29.9 kg/m2.
3. Radiographic evidence of grade I- II osteoarthritis of knee joint, based on the
Kellgren and Lawrence radiographic e... | Assessment of the Efficacy of ParActin® in Subjects With Mild to Moderate Osteoarthritis | NCT03262792 | Entailment |
69 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
decreased serum testosterone concentration below the normal range (serum T < 300ng/dL), FSH
and LH levels within or below the normal range, absence of a pituitary or hypothalamic mass
lesions on MRI, presence of gonadotropin response to repetitive doses of GnRH, normal smell... | Plasma RBP Levels in Patients With Idiopathic Hypogonadotrophic Hypogonadism | NCT01758094 | Contradiction |
3,619 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Any patient consulting in the emergency department during the study period
Exclusion Criteria:
- Patients attending the emergency departments as part of dressing or trauma follow-up
consultations
No condition on gender to be admitted to the trial.
No h... | Impact of Biological Point of Care Devices Implementation on the Length of Stay of Patients in Emergency Room | NCT03840564 | Entailment |
1,346 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Boys and girls.
- Aged from 0 to 18 years old.
- Subjects with an Achondroplasia diagnosis.
- Patients or parents/ legal guardian must provide non opposition prior to participation
in the study.
Exclusion Criteria:
- Pa... | Radiological Analysis on Patients With Achondroplasia Disorder | NCT04184817 | Entailment |
6,228 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
Each subject must meet all of the following inclusion criteria to be randomized to
treatment:
1. Willing and able to provide written informed consent
2. Aged ≥ 18 years
3. SARS-CoV-2 infection confirmed by PCR ≤ 4 days before randomization
... | A Clinical Study to Assess the Efficacy and Safety of Amizon® Max in the Treatment of Moderate Covid-19 | NCT04682873 | Contradiction |
4,197 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Couples Inclusion Criteria:
1. Heterosexual couples in a committed relationship with a female partner aged 18-45
years and male partner aged 18 years and older attempting to conceive and seeking
assisted reproduction at participating fertility clinics.
2. Couples actively... | Folic Acid and Zinc Supplementation Trial (FAZST) | NCT01857310 | Contradiction |
1,414 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Nonsmoker >= 6 months prior to first dose
- body mass index (BMI) <= 36 kg/m2
- Meet American College of Rheumatology (ACR) clinical classification criteria for
osteoarthritis of knee by meeting at least 3 of the following: age > 50, morning
... | A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-39439335 in Patients With Osteoarthritis | NCT01343303 | Contradiction |
6,342 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Patients who had fever (central temperature ≥38°C) or acute upper respiratory symptoms
and laboratory confirmation (rRT-PCR) for COVID-19, with available same type of upper
respiratory tract specimens from screening evaluation to the initial testing within 4
... | Efficacy and Tolerability of Hydroxychloroquine in Adult Patients With COVID-19 | NCT04384380 | Entailment |
5,662 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- All students who accept to participate in the study
Exclusion Criteria:
- Students who refused to participate in the study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most ... | Evaluation of the Effectiveness of Internet Based Nutrition and Physical Activity Education Programme in Adolescents | NCT02297919 | Contradiction |
6,893 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
1. Older than 55-year-old，male or female.
2. patients meet the diagnosis of mild cognitive impairment (MCI) or Alzheimer's
disease(AD) or whose family members were diagnoed with AD
3. Complete self-rating scale for memory impairment (AD-8 scale)
... | Proteomics Study of Mild Cognitive Impairment and Alzheimer's Disease | NCT04804618 | Entailment |
970 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Enrolled to receive medical care at the Michael E. DeBakey VA Medical Center
- At least 3 joints affected by distal interphalangeal (DIP) nodal hand OA
- DIP nodal hand OA will be defined as Heberden's nodes on physical exam.
- Sufficiently severe fr... | A Pilot Randomized Controlled Trial for Hand Osteoarthritis | NCT04784065 | Entailment |
4,129 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Subjects must be aged between 18 to 35 years
2. Have a diagnosis of atopic asthma (based on at least one positive skin prick test and
methacholine PC20 ≤16 mg/ml)
3. FEV1 ≥ 70% of predicted
4. Demonstrate a cough response to capsaicin with ... | Effect of Sex Hormone During the Menstrual Cycle on Capsaicin Evoked Cough Responses | NCT04233762 | Contradiction |
651 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Male,
- At least 18 years old
- BMI > 25 Kg/m2
- Serum ferritin level between 100 et 300 µg/L
- Written informed consent
Exclusion Criteria:
- Blood donations in the past two years
- Alcohol consumption mo... | Evaluation of Body Iron Stores in Overweight Healthy Volunteers | NCT02304874 | Contradiction |
1,524 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- All the patients who referred for video-fluoroscopic-swallowing study
Exclusion Criteria:
- none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
| Feasibility of a Water-soluble Contrast Application Into Dysphagia Evaluation | NCT03598491 | Entailment |
109 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Men, 40-70 years of age, in a stable relationship, with mild to moderate erectile
dysfunction for at least 6 months; defined as an IIEF-EF domain score between 11 and
25 (mild to moderate ED)
- Neutral or extremely dissatisfied with one's sex life
... | Effect of Testosterone in Men With Erectile Dysfunction | NCT00512707 | Contradiction |
1,330 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Achondroplasia without epiphyseal line closure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 15 Years | Special Survey for Long Term Application | NCT01516229 | Contradiction |
3,227 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Subject is female between the ages of 18 and 49 years (at lease 21 subjects) or 50-60
years (no more than 9 subjects);
- Subject is using adequate non-barrier method of birth control [established us of
hormonal methods of contraception (oral, injec... | A Single-Center, Clinical Study to Evaluate the Safety of a Fragranced Personal Lubricant in Healthy Female Subjects | NCT02320214 | Entailment |
6,118 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Adults (˃18 years) COVID-19 positive patients (confirmed by PCR).
- Moderate infection ( pneumonia ± leucopenia or lymphopenia ).
Exclusion Criteria:
- Severe or life threatening COVID infection: Severe disease is defined as: dyspnea,
respi... | Efficacy and Safety of Sirolimus in COVID-19 Infection | NCT04461340 | Contradiction |
6,088 | 45 | A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is o... | My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor dia... | - INCLUSION CRITERIA:
- Adults (at least 18 years of age) with a diagnosis of DS (including mosaic DS or
partial trisomy 21) who are capable of providing consent to participate, or for whom a
legally authorized representative (LAR) may give permission on behalf of the
... | DS-Connect {TM}: The Down Syndrome Registry | NCT01950624 | Entailment |
4,134 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Non-smoking healthy male firefighters or volunteers
Exclusion Criteria:
- Current smoker or regular users of snus
- History of lung or ischaemic heart disease
- Malignant arrhythmia
- Systolic blood pressure >190mmHg or <100mmHg
... | Effect of Woodsmoke on Vascular Function | NCT01495325 | Contradiction |
4,456 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Cases diagnosed with lateral epicondylitis by the physician and decided to receive
conservative treatment
- Not receiving NSAID or other medical treatment
- Untreated Lateral Epicondylitis for the last 6 months
- Cases with age range 18-... | Examining The Efficacy Of Scapular Exercises On Pain And Function İn Patients With Lateral Epicondylitis | NCT04141488 | Contradiction |
3,093 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Being between the ages of 12-18
- Mild to moderate intellectual disability
- Parents agree to participate in research.
- Lack of speech and vision impairment
- Completing all trainings and follow-ups during the research period
Ex... | Determining the Effectiveness of Sexual Health and Development Education for Children With Intellectual Disability | NCT04635969 | Entailment |
1,691 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:- Potential participants will be any patient that is seen at Stanford
Dermatology or LPCH that has a cyst, nodule, vesicle, tumor, or possible pilomatricoma
Exclusion Criteria:- Inability of subject or subject's guardian to understand informed
consent form.
No condition on gen... | Use of Otoscope as a Non-Invasive Tool for Diagnosis of Pilomatricoma | NCT00715819 | Entailment |
6,811 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
Inclusion criteria for patients/caregivers in the Patient/Caregiver Study:
- Patients with hemophilia A (≥ 18 years of age) or caregivers of children with
hemophilia A (≥12-<18 years of age)
- Group 1: Hemophilia A patients/caregivers who have switched t... | Evaluation of Patient and Physician Reported Reasons for Switching Factor VIII Replacement Therapies | NCT03405337 | Entailment |
6,771 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
Diagnosis of hemophilia or other severe bleeding disorders. Signed inform consent
Exclusion Criteria:
None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Swiss Hemophilia Registry | NCT02512250 | Entailment |
4,300 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Heterosexual, monogamous couples, of any race or ethnicity, who are sexually active
- 20 - 50 years of age
- Signed Informed Consent
- Past experience with using condoms
- Trying to conceive or using a non-vaginal birth control with which... | Usability Study of the Focus Touch™ Conception System: Semen Collection | NCT01585012 | Entailment |
2,033 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- gastric adenocarcinoma proven by endoscopic biopsy;
- application of both computed tomography and diffusion weighted magnetic resonance
imaging;
- standard gastrectomy and a D2 lymph node dissection;
- desire to attend the study protocol... | Diffusion Weighted Magnetic Resonance Imaging for Preoperative Staging in Gastric Adenocarcinoma Patients | NCT01794026 | Entailment |
3,637 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- All patients presenting to the EDs during the study period will be included as far as
they do not actively ask to not be included in the study. Patients presenting during
the control period, will be allocated to the control group, while patients presenting
... | Integrating the Clinical Pharmacists Into Emergency Department Teams | NCT04722588 | Entailment |
2,732 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- any type of inguinal hernia
Exclusion Criteria:
- active urinary tract infection,
- previous BPH, neurological disease or significant systemic disease,
- medications that could interfere voiding function
- history of prostate, bl... | Effect of Inguinal Hernia Repair on Uroflowmetric Parameteres | NCT03450811 | Entailment |
4,377 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Body mass index ≥ 18 and ≤ 30 (kg/m2)
- Medically healthy with normal screening results, or in the case of results that are
abnormal; the abnormal results are clinically insignificant (eg, medical history,
physical examination, neurological assessm... | Multiple-Ascending-Dose Study to Evaluate the Safety of Propoxyphene Napsylate In Healthy Adult Subjects | NCT01133873 | Entailment |
5,483 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Male or female age 18-75
- If female, subject is not of child bearing potential. Defined as females who have
- had a hysterectomy or oophorectomy.
- bilateral tubal ligation or are post-menopausal (natural or surgically with > 1 year
sin... | Safety and Efficacy of Cunermuspir on Energy, Strength, and Fatigue in Patients With Nerve or Muscle Pain | NCT04737278 | Contradiction |
6,563 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Healthy volunteers
Inclusion Criteria:
- Age 18 - 60 years,
- Non smoker,
- Good general health and physical fitness
- Informed Consent
Exclusion Criteria:
- Current or history of tobacco smoking (> 5 py)
- Current alcohol or drug... | Validation of a Miniature SpO2 Sensor in Healthy Subjects and Patients With Long-term Oxygen Therapy. | NCT02723032 | Contradiction |
3,391 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Diagnosed with ear fluids (OME) according to a doctor's examination for at least 4-6
weeks. There is a progressive hearing impairment and a matching tympanum.
- In principle, these children (with OME and hearing impairment) meet the criteria and
ca... | A Non-invasive Device to Remove Fluid From the Middle Ear | NCT03978195 | Contradiction |
5,630 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Both parental guardians (mother and father) and target child must be of Hispanic or
African American descent
- Child must be between the ages of 9-14 years
- Child must be overweight/obese as defined by a body mass index percentile for age-
... | BOUNCE to Health: A Healthy Lifestyle Program | NCT03925012 | Contradiction |
812 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. KOA according to the clinical American College of Rheumatology (ACR) criteria. The
clinical ACR criteria for KOA are: knee pain and at least 3 of the 6 following
features: age ≥50, morning stiffness <30 minutes, crepitus, bony tenderness, bony
enl... | Exercise Therapy for Osteoarthritis Pain: How Does it Work? | NCT04362618 | Entailment |
6,519 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Diagnosis of severe hemophilia A defined as <1% FVIII:C documented in medical records.
- Males between 18 and 65 years of age (Parts 1 and 2).
- Males between 12 and 65 years of age (Part 3).
- Subjects who have received or are currently receiving FV... | An Open-label Safety, Efficacy and Pharmacokinetic Study of a Recombinant FVIII Compared to Recombinant Human Antihemophilic FVIII in Patients With Severe Hemophilia A | NCT01486927 | Contradiction |
6,336 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients presenting with COVID symptoms to hospitals.
- Patients >18 years old
Exclusion Criteria:
- Patients without capacity to consent
- Pulmonary oedema secondary to decompensated cardiac, renal or liver disease at the
time ... | COVID-19 Pathophysiology of Long Term Implications | NCT04813575 | Entailment |
2,030 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Key Inclusion Criteria:
- provide archive tumor tissue samples or accept fresh tumor tissue biopsy(Sample
requirements are: formalin-fixed and paraffin-embedded wax blocks of tumor tissue or
at least 20 unstained tumor specimen slides).
- assessed by the surgery can be ... | Study of Perioperative Chemotherapy Combined With Tirelizumab and Trastuzumab in the Treatment of GC/EGC | NCT04819971 | Entailment |
924 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Male or female subjects may be recruited in to the Investigation.
- Age - The subject must be at least 21 years of age and skeletally mature as
demonstrated radiographically by complete closure of the distal femoral and proximal
tibial epiphyses.
... | Robotic Arm Assisted Total Knee Arthroplasty | NCT02058069 | Entailment |
6,792 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- 18-75 years of age, of either sex or any race
- Clinical history of at least 2 lipomas for at least one year
- Lipomas diagnosed as benign
- Two lipomas on distinctly separate parts of the body, or on the torso if 30 cm apart,
with easil... | Double Blind Study to Evaluate the Efficacy of Collagenase Histolyticum in the Treatment of Lipoma | NCT02249052 | Entailment |
4 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Adult male subject aged 18 to 65 years inclusive
- BMI > 30 kg/m2 and < 50 kg/m2
- Serum total testosterone concentration below the normal range
- LH levels below the upper limit of normal
- Oestradiol levels within or above the normal ra... | A Phase IIb Multicentre, Double-Blind, Dose-Ranging, Randomised, Placebo-Controlled Study Evaluating Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism | NCT02730169 | Contradiction |
5,797 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- clinically and histologically confirmed painful Erosive or Atrophic OLP
- free from any systemic diseases using medical questionnaire guided by Cornell Medical
Index
Exclusion Criteria:
- history of drug induced lichenoid lesions
... | Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus | NCT02443311 | Contradiction |
1,538 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- patients with established RA
- age between 18 and 65 years
- disease modifying anti-rheumatic drugs (DMARDs) stable for at least 3 months
- synovitis in wrist with pain visual analogic scale (VAS) between 4 and 8cm
Exclusion Criteria:
... | Effectiveness Intraarticular Corticosteroid | NCT01851278 | Contradiction |
148 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Overweight/obese (BMI = or > 27 kg/m2)
- Older (65-85 yr)
- Male veteran patients being seen at the PI's endocrine clinic and receiving standard
of care consisting of diet and regular exercise counseling
- Diagnosed with hypogonadism on ... | Long-term Lifestyle Change and Testosterone Replacement | NCT03256292 | Contradiction |
1,829 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion criteria:
A. Males and females of age 18-55. B. A diagnosis of epigastric pain/discomfort (located in
the upper abdomen) rated by the patient as moderate to severe in intensity (on a four-point
categorical scale), which has been present at least 3 times per week for 12 weeks,
... | Inhibition of Gastric Acid is the Key to Satisfactory Relief of Symptoms With Esomeprazole in NUD Patients | NCT00222131 | Entailment |
4,294 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
One of the following conditions:
- Sexually transmitted disease evaluation or prior history of sexually transmitted
disease
- Pregnancy
- Clinical condition that suggests possible immunodeficiency
- History of illicit drug use
... | Rapid HIV Testing Program in the Emergency Department | NCT00548041 | Entailment |
6,316 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- >= 60 years of age
- COVID-19 infection, confirmed by polymerase chain reaction (PCR) test <=5 days from
enrollment done in the ambulatory setting
- Able to provide informed consent
- Symptom related to COVID-19. This includes: fever or ... | Camostat With Bicalutamide for COVID-19 | NCT04652765 | Entailment |
5,242 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- patients with a diagnosis of osteoporosis and with or without fracture
- post- menopausal women
- age > 48 years
Exclusion Criteria:
- vitamin D supplementation in recent 6 months
- patients on steroid
- age < 48 year... | Study on the Correlation of Free Vitamin d With BMD and Fracture | NCT03605173 | Entailment |
2,977 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Moderate or severe intellectual disability
- Availability of patient and parent DNA
- No etiologic diagnosis with standard approaches: negative fragile X, normal pangenomic
180K and 1M array-CGH
- Informed consent of person having parent... | Targeted Next Generation Sequencing and Intellectual Disability | NCT02889068 | Contradiction |
3,659 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | THIS STUDY IS BEING CONDUCTED AT A MILITARY INSTALLATION. YOU MUST HAVE MILITARY INSURANCE
IN ORDER TO PARTICIPATE IN THIS STUDY.
Inclusion:
DoD beneficiaries between the ages of 18-65 years old Symptoms of Low Back Pain greater
than 12 weeks duration Patients with a history of lower b... | The Use of Methylsulfonylmethane (MSM) in the Treatment of Low Back Pain | NCT02268305 | Contradiction |
2,816 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Diagnosis of possible or more definite ALS according to the El Escorial criteria
- SVC >50% of predicted for age, height and gender.
- At least four of 12 ALSFRS-R questions scored as 2 or 3 at screening.
- Diminished but measurable grip strength (1)... | Clenbuterol on Motor Function in Individuals With Amyotrophic Lateral Sclerosis | NCT04245709 | Entailment |
6,285 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Patient with symptoms of COVID-19 (fever, headache, cough, sore throat, myalgias,
arthralgias, shortness of breath, anosmia, fatigue, diarrhea, vomit, or
conjunctivitis) meeting criteria for mild or moderate COVID-19 according to the
following cri... | Local Thermotherapy for Patients With Mild-to-moderate COVID-19 | NCT04363541 | Entailment |
5,909 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- age more than 20 years old and less than 70 years old
- typical gastroesophageal reflux symptoms (heart burn and acid reflux)
- outpatient
- complete upper gastrointestinal endoscopy
Exclusion Criteria:
- age less than 20 years o... | Waist Circumference Versus Body Mass Index to Predict Severity of Gastroesophageal Reflux Disease | NCT00698178 | Contradiction |
4,041 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Able to provide written informed consent to participate in the study;
- Willing and able to comply with all study requirements and instructions of the site
study staff;
- Must be ambulatory;
- Study knee must have a clinical diagnosis of... | AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee | NCT03182686 | Entailment |
5,219 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Primary complaint of back pain
- Modified Oswestry Disability Index > 10 points=20%
Exclusion Criteria:
- Red flags noted in the patient's Low Back Medical Screening (i.e. tumor, fracture,
metabolic diseases, Rheumatoid Arthritis, prolonged... | Dry Needling for Patients With Back Pain | NCT03586778 | Entailment |
6,326 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Age >18 years
- COVID PCR + patient: Patient screened positive by PCR on nasopharyngeal swab
- or COVID-like patient: Patient not screened, but considered COVID + because contact
with a COVID PCR + person, and presenting symptoms suggestive of COVID... | Observational Study in Diagnosed Patients COVID-19, Supported on an Outpatient Basis. (COVID-PSL) | NCT04402905 | Entailment |
6,246 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Laboratory diagnosis:
- Respiratory specimen is positive for SARS-CoV-2 nucleic acid by RT-PCR; OR,
- The viral gene sequencing of the respiratory specimen is highly homologous to
known novel coronavirus.
2. Fever:
... | Recombinant Human Angiotensin-converting Enzyme 2 (rhACE2) as a Treatment for Patients With COVID-19 | NCT04287686 | Contradiction |
2,476 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- Patients with retina, glaucoma and neuroophthalmic disorders
- Patients with normal eye exams to act as controls
- Must be able to comprehend instructions and perform visual fields
Exclusion Criteria:
- Patients <18years old
- Pa... | Assessment of Visual Function in Ophthalmic Disorders Using Virtual Visual Field Analysis | NCT04110015 | Contradiction |
4,678 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Age of 18 through 45 years at screening, verified per site SOP
2. Female participants, born female
3. Not pregnant or breastfeeding
4. Availability to return for all study visits, barring unforeseen circumstances
5. Willing and able to
... | PrEP-Pod-IVR (TDF-FTC/Placebo IVR 28 Day Crossover Study) | NCT03255915 | Entailment |
856 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- radiographically assessed osteoarthritis of the knee graded 1 to 4 according to the
Kellgren and Lawrence scale
- self reported moderate to severe level pain
Exclusion Criteria:
- acute septic arthritis
- predisposition to a ten... | The Effect of Neuromuscular Training on Osteoarthritis: A Comparative Prospective Randomized Study | NCT00457132 | Entailment |
3,744 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- symptomatic knee osteoarthritis
Exclusion Criteria:
-
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years | Motivators and Barriers to Physical Activity in Knee Osteoarthritis Patients: a Qualitative Study | NCT02777684 | Contradiction |
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