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Thoracoscopic carbon dioxide laser treatment of bullous emphysema. A new technique of thoracoscopic laser ablation of pulmonary bullae suitable for patients with multiple bullae and diffuse emphysema was developed and assessed in 22 patients. 20 of 22 patients survived. Pre-operative and postoperative functional evalua... | general pathological conditions |
Endoscopic transpapillary therapy for disrupted pancreatic duct and peripancreatic fluid collections. Eighteen patients with active pancreatic ductal disruptions, including 14 with definable fluid collections, were treated with transpapillary pancreatic duct drains or stents. Twelve of these patients had undergone a pr... | digestive system diseases |
Immediate and short-term cardiovascular effects of fosinopril, a new angiotensin-converting enzyme inhibitor, in patients with essential hypertension. Immediate and short-term cardiovascular effects of a new angiotensin-converting enzyme inhibitor, fosinopril, were assessed in 10 patients with mild to moderate essentia... | cardiovascular diseases |
Monomicrobial nonneutrocytic bacterascites: a variant of spontaneous bacterial peritonitis. Spontaneous bacterial peritonitis is diagnosed when (a) the ascitic fluid culture is positive, (b) the ascitic fluid neutrophil count is greater than or equal to 250 cells/mm3 and (c) there is no evident intraabdominal surgicall... | general pathological conditions |
Pulmonary function and cardiovascular risk factor relationships in black and in white young men and women. The CARDIA Study Pulmonary function is known to be related inversely to incidence of coronary heart disease, congestive heart failure, chronic obstructive lung disease, lung cancer, and death from all causes. Reas... | cardiovascular diseases |
Intraoperative electron beam radiation therapy for recurrent locally advanced rectal or rectosigmoid carcinoma. A multimodality approach of moderate-dose to high-dose preoperative radiation therapy, surgical resection, and intraoperative electron beam radiation therapy (IORT) has been used for patients with locally rec... | neoplasms |
Giant cell arteritis. A case with unusual neurologic manifestations and a normal sedimentation rate. Giant cell (temporal) arteritis is a serious inflammatory condition that can lead to blindness, stroke, or other adverse sequelae if not properly treated. An elevated erythrocyte sedimentation rate has traditionally bee... | cardiovascular diseases |
Morphological observations late (greater than 30 days) after clinically successful coronary balloon angioplasty. This report describes clinical, morphological, and histological findings late (1.6-24.1 months [average, 8.2 months]) after clinically successful coronary balloon angioplasty in 20 necropsied patients with c... | general pathological conditions |
Impaired production of tumor necrosis factor in breast cancer. Spontaneous and lipopolysaccharide (LPS)-induced production of tumor necrosis factor (TNF) by peripheral blood macrophages was investigated in breast cancer. Whereas spontaneous TNF production by macrophages derived from patients with breast cancer was comp... | neoplasms |
Evaluation and therapy of breakthrough bleeding in women using a triphasic oral contraceptive. This study was designed to investigate the incidence and pattern of breakthrough bleeding (BTB) in 1,259 women who were prescribed for the first time a triphasic oral contraceptive (OC, 7-7-7) and to evaluate a hypothesis of ... | general pathological conditions |
The prevalence of Helicobacter pylori infection in the Peoples Republic of China. Meta-analysis on data from 16 (two volunteer and 14 endoscopic) studies ahs been performed to investigate the prevalence of Helicobacter pylori infection in the stomachs of individuals within the Peoples Republic of China. In this survey ... | general pathological conditions |
The diagnosis and prognosis of autosomal dominant polycystic kidney disease. BACKGROUND. Autosomal dominant polycystic kidney disease is usually caused by a mutant gene at the PKD1 locus on the short arm of chromosome 16, but in about 4 percent of families with the disorder it is caused by unknown mutations elsewhere i... | cardiovascular diseases |
Electrocardiographic markers of ischemia during mental stress testing in postinfarction patients. Role of body surface mapping. In patients with coronary artery disease, radionuclide investigations have documented a high incidence of mental stress-induced myocardial ischemia in the absence of significant electrocardiog... | cardiovascular diseases |
Lateral medullary infarction: prognosis in an unselected series. We describe the acute and long-term prognosis in 43 patients with lateral medullary infarction (LMI) collected from a population-based stroke registry from 1982 to July 1988. Mean age was 63.9 years and median time of follow-up was 33 months. In the acute... | nervous system diseases |
Direct monitoring of capillary perfusion following normovolemic hemodilution in an experimental skin-flap model. The effects of normovolemic hemodilution on skin flap survival are studied in a recently developed skin-flap model (homozygous hairless mouse ear) in which nutritional capillary flow is monitored directly by... | cardiovascular diseases |
The surgical pathologist's role in liver transplantation. Liver transplantation has become an option in treating a wide variety of diseases. The surgical pathologist, as a member of the transplantation team, is increasingly involved in the evaluation of allograft dysfunction. Interpretation of the liver allograft biops... | general pathological conditions |
Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Evidence has accumulated that nonsteroidal anti-inflammatory drugs (NSAIDs) cause clinically important gastroduodenal ulcers. The pathogenesis, which involves the impairment of mucosal resistance to injury in an acid-peptic environment, is multifactorial an... | digestive system diseases |
The Indian experience with hypertrophic pyloric stenosis. A study of 58 consecutive Indian infants operated for congenital hypertrophic pyloric stenosis revealed an accentuated male predominance in the incidence of the disease and far less preoperative hemetemesis as compared to that in their Western counterparts. 'Pyl... | general pathological conditions |
Use of the variable-length intraluminal sutureless graft. From August 1987 to May 1988 we treated 4 patients with acute ascending aortic dissections with a variable-length intraluminal aortic prosthesis. This operation uses profound hypothermic circulatory arrest and represents a refinement of existing techniques. Ther... | cardiovascular diseases |
Localization of technetium-99m-glucarate in zones of acute cerebral injury. The potential structural similarity of technetium-99m-labeled glucaric acid (99mTc-glucarate) to that of fructose suggests that this agent may enter cells by a sugar transport system. Studies with LLC-PK1 cells demonstrated inhibition of 99mTc-... | nervous system diseases |
Severity of cystic fibrosis in patients homozygous and heterozygous for delta F508 mutation. To assess the relation between genotype and severity of disease in cystic fibrosis (CF) the frequencies and extent of several features of its phenotypic expression were investigated in the 235 patients who attend the Danish CF ... | general pathological conditions |
Studies of controlled reperfusion after ischemia. XX. Reperfusate composition: detrimental effects of initial asanguineous cardioplegic washout after acute coronary occlusion. This study tests whether initial asanguineous washout of potentially toxic substances that accumulate during ischemia improves recovery produced... | general pathological conditions |
Cigarette smoking, gastric acidity and peptic ulceration. What are the relationships? The influence of cigarette smoking on intragastric acidity was assessed in duodenal ulcer patients in symptomatic remission and in healthy volunteers in a retrospective study. Continuous 24-hr pH recordings in 150 nonsmokers and 174 s... | digestive system diseases |
Reoperation for biliary strictures. Benign bile duct strictures most often follow intraoperative injury not recognized until later. The ideal reconstruction entails a mucosa-to-mucosa anastomosis without tension, usually with a stent tube to maintain patency in the immediate postoperative period. The mortality rate for... | general pathological conditions |
High ethanol consumption as risk factor for intracerebral hemorrhage in young and middle-aged people. We examined the prevalence of high ethanol intake, hypertension, and other risk factors for intracerebral hemorrhage in a case-control study of 24 young and middle-aged patients with intracerebral hemorrhage. We record... | digestive system diseases |
Dietary fats and oils in cardiac arrhythmia in rats. The effect of long-term feeding of various dietary fats and oils on cardiac arrhythmia was studied in an animal model of sudden cardiac death. After confirmation that a dietary supplement of saturated animal fat (SF) increased the animals' susceptibility to develop c... | cardiovascular diseases |
Symptoms of Raynaud's syndrome in patients with fibromyalgia. A study utilizing the Nielsen test, digital photoplethysmography, and measurements of platelet alpha 2-adrenergic receptors. Twenty-nine female patients with fibromyalgia were questioned about symptoms of cold intolerance and Raynaud's syndrome; objective do... | nervous system diseases |
The future of nephrology. The Cellular and Molecular Age of Nephrology has dawned and the future is remarkably exciting. The successful attack on the major causes of renal disease, including genetic diseases, glomerulonephritis, diabetes, vasculitis, acute renal failure, and hypertension, will necessitate improved know... | cardiovascular diseases |
The Marinesco-Sjogren syndrome examined by computed tomography, magnetic resonance, and 18F-2-fluoro-2-deoxy-D-glucose and positron emission tomography. The Marinesco-Sjogren syndrome is an autosomal recessive degenerative disorder characterized by congenital cataracts, cerebellar ataxia, spasticity, mental deficiency,... | general pathological conditions |
How and why aztreonam works. Aztreonam is the first monocyclic beta-lactam antibiotic (monobactam) to be tested clinically. Its synthetic structure determines specific areas of activity, including enhanced activity against Pseudomonas species, exceptional activity against gram-negative bacteria, stability to beta-lacta... | general pathological conditions |
A study of fatigue in systemic lupus erythematosus. Fifty-nine patients with systemic lupus erythematosus were evaluated by questionnaires, histories, physical examinations and routine laboratory studies in order to better understand their fatigue. The fatigue severity scale (scored from 1 to 7) was used to measure fat... | general pathological conditions |
Emergency laparoscopy. Unnecessary abdominal explorations in severely injured patients can be reduced by employing emergent or urgent laparoscopy in blunt abdominal trauma and the obscured, acute abdominal cases. In 150 blunt abdominal trauma cases, a mini-laparoscopy was used in the emergency room or the intensive car... | digestive system diseases |
Kaposi's sarcoma of the colon in a young HIV-negative woman with Crohn's disease. We report a case of isolated colonic Kaposi's sarcoma in a 36-year-old HIV-negative woman with refractory Crohn's disease of the colon and perineum following 11 months' treatment with azathioprine. The clinical features of this case are q... | digestive system diseases |
Carotid-esophageal fistula following a penetrating neck injury: case report. Carotid arterial injuries frequently are associated with injuries to adjacent structure of the neck, particularly the esophagus and trachea. Complications from these repairs are common and fistula formation is herein described between the caro... | general pathological conditions |
Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor. Expression of insulin-like growth factor I (IGF-I) mRNA by some tumor cell lines of neuroectodermal origin has been described. To further explore the significance... | general pathological conditions |
Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Epstein-Barr virus (EBV), a human herpesvirus, establishes a persistent asymptomatic infection of the circulating B-lymphocyte pool. The mechanism of virus persistence is not understood but, given the limited lifespan of most ... | neoplasms |
Bilateral breast cancer. A second primary breast cancer in the opposite breast can be either synchronous or metachronous. The majority are metachronous. A woman who has had breast cancer has a fivefold increase in risk for a second breast cancer. Additional risk factors include multifocal cancer, lobular carcinoma in s... | neoplasms |
Esophageal malignancies: is preoperative radiotherapy the way to go? During the period 1969 to 1988, 68 patients with esophageal malignancy were subjected to preoperative radiotherapy consisting of 30 Gy over 3 weeks followed by esophagectomy after a wait of 2 weeks. Sixty-two of 68 patients (91%) were followed up retr... | general pathological conditions |
Long-term outcome after surgical repair of isolated atrial septal defect. Follow-up at 27 to 32 years BACKGROUND. Atrial septal defects have been surgically correctable for more than 30 years. The long-term survival rates among patients treated in the early era of cardiac surgery are poorly documented, but such data ar... | cardiovascular diseases |
Endothelin-like immunoreactivity in human breast cyst fluid. Immunoreactive endothelin has been detected in 21 of 43 samples of breast cyst fluid (21 cases; 3.5 +/- 0.6 pmol/l, mean +/- SEM. Other 22 cases; not detectable, less than 0.5 pmol/l). Fast protein liquid chromatographic analysis of the immunoreactive endothe... | neoplasms |
Evaluating tooth eruption on sealant efficacy. For patients aged 5 to 9 and 11 to 14, 100 occlusal surfaces on newly erupting permanent molars were treated with a self-curing pit and fissure sealant. All teeth were categorized according to stage of eruption and sealant thickness of the coating applied. After 36 months,... | general pathological conditions |
Prosthetic arthroplasty of the knee after resection of a sarcoma in the proximal end of the tibia. A report of sixteen cases. The results of a specific type of prosthetic reconstruction of the knee (total replacement arthroplasty) after resection of a sarcoma of the proximal part of the tibia in sixteen patients were r... | neoplasms |
Prognostic indices for tumor relapse and tumor mortality in follicular thyroid carcinoma. To establish an objective basis for therapeutic decisions and follow-up programs in patients with follicular thyroid cancer, the authors developed a prognostic scoring system. The prognostic impact of nine clinical, histologic, an... | general pathological conditions |
Indwelling epidural catheters for pain control in gynecologic cancer patients. Seven patients with severe pain caused by an advanced, incurable gynecologic malignancy were treated with an indwelling epidural catheter connected to an implantable subcutaneous port through which morphine was infused. There were few major ... | nervous system diseases |
Multicenter long-term safety and efficacy study of vigabatrin for refractory complex partial seizures: an update. We followed 66 patients with refractory complex partial seizures and a favorable initial response to vigabatrin for 5 to 72 (median, 43) months. Thirty-seven patients discontinued vigabatrin for the followi... | nervous system diseases |
Takayasu's disease with axillary, right coronary artery, and right internal mammary stenosis treated with angioplasty. A 47-year-old woman presented with progressive angina and failed medical therapy. After an unsuccessful attempt at angioplasty of a totally occluded right coronary artery, coronary artery bypass using ... | general pathological conditions |
Foreign bodies in the throat: a prospective study of 388 cases. We present the results of a prospective study of 388 patients presenting with a history of swallowing a foreign body. We indicate whether the patients' symptoms and signs were associated with a retained foreign body. While tenderness on palpation was an un... | general pathological conditions |
Protamine transcript sharing among postmeiotic spermatids. Sharing of cytoplasmic constituents through intercellular bridges connecting postmeiotic spermatids can allow for functional equivalence of genetically nonequivalent spermatids. The technique of in situ hybridization was used to study postmeiotic distribution o... | general pathological conditions |
Distribution of angiographic vasospasm after subarachnoid hemorrhage: implications for diagnosis by transcranial Doppler ultrasonography. A study was undertaken to determine how frequently angiographic vasospasm occurs outside the normal access range of transcranial Doppler ultrasound in patients who have suffered a su... | cardiovascular diseases |
Cellular immune response toward human articular chondrocytes. T cell reactivities against chondrocyte and fibroblast membranes in destructive joint diseases. Articular cartilage is one of the major targets in destructive joint diseases in humans. We studied cellular immune reactions against cartilage cell-surface membr... | neoplasms |
Differential regulation of liver P-450III cytochromes in choline-deficient rats: implications for the erythromycin breath test as a parameter of liver function. Progressive liver fibrosis in rats develops when they are fed a diet deficient in choline. This diet also results in a pronounced and selective decrease in the... | digestive system diseases |
t(3;21)(q26;q22): a recurring chromosomal abnormality in therapy-related myelodysplastic syndrome and acute myeloid leukemia. We have identified an identical reciprocal translocation between the long arms of chromosomes 3 and 21 with breakpoints at bands 3q26 and 21q22, [t(3;21)(q26;q22)], in the malignant cells from f... | general pathological conditions |
Human papillomavirus associated with poor healing of episiotomy repairs. A retrospective case-control investigation was conducted for risk factors in 47 parturients whose episiotomies dehisced in the immediate postpartum period. Data were extracted from the inpatient, outpatient, and pathology records of each of these ... | general pathological conditions |
Cor triatriatum: clinical presentation and surgical results in 12 patients. Twelve patients with cor triatriatum have been seen at our institution since 1979. The clinical presentation, diagnostic evaluation, and surgical results are outlined in this retrospective review. Operation is the treatment of choice for this r... | cardiovascular diseases |
Clinical management of gastric cancer and concomitant esophagogastric varices. We report the late results of treatment of 13 consecutive patients with gastric cancer and concomitant esophagogastric varices. Of seven good-risk patients classified as Child's class A or B, gastrectomy together with selective shunt operati... | digestive system diseases |
Infiltration of the lower respiratory tract by helper/inducer T lymphocytes in HTLV-1-associated adult T-cell leukemia/lymphoma. The human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL), a disorder in which peripheral blood and multiple organs are infiltrated b... | neoplasms |
Evaluation of the magnitude of gastro-oesophageal reflux in Barrett's oesophagus. A manometric study to determine the role of gastro-oesophageal reflux in Barrett's oesophagus was performed on 20 patients with Barrett's oesophagus and 53 patients with reflux oesophagitis without Barrett's oesophagus (25 with mild oesop... | digestive system diseases |
Stair climbing as an exercise test to predict the postoperative complications of lung resection. Two years' experience. The results of a clinically performed preoperative stair climb was compared to the presence of postthoracotomy complications in the retrospective hospital record review of 54 adult men. The stair clim... | general pathological conditions |
Clinical experience with the Nimbus pump. The Nimbus pump is an indwelling, electromagnetic powered left ventricular (LV) assist device inserted transfemorally. The inflow cannula (7 mm) is positioned across the aortic valve and the pump in the descending aorta. Indications for insertion include cardiogenic shock despi... | general pathological conditions |
Persistent carcinoma in situ of the testis after chemotherapy for advanced testicular germ cell tumours. The chemosensitivity of testicular carcinoma in situ (CIS) was analysed in 25 testes excised 10 weeks to 4.5 years following platinum-based chemotherapy. CIS was present in 8 of the 23 evaluable cases (35%), in 5 of... | general pathological conditions |
Meningiomas mimicking cerebral schwannoma. A brain tumor with histological features reminiscent of schwannoma with underlying meningioangiomatosis was subjected to electron microscopic and immunohistochemical analysis, which confirmed the neoplasm as a meningioma. This prompted reexamination of a similar tumor, describ... | nervous system diseases |
Clinical experience with the Medtronic-Hall valve prosthesis. Medtronic-Hall valves were implanted during 204 procedures performed between 1982 and 1988. Mean population age was 54.4 years; 96% of patients were in New York Heart Association functional class III or greater. Emergency operations constituted 16% of the pr... | general pathological conditions |
Barium meals in the elderly--a quality reassurance. The consecutive double contrast barium meal examinations of 100 elderly patients (aged over 65 years) and a group of 33 younger adult patients were analysed by two observers for technical quality and pathological abnormalities. Technical quality declined with patient ... | digestive system diseases |
The electrocardiogram in chronic obstructive pulmonary disease. The electrocardiogram is often abnormal in patients who have chronic obstructive pulmonary disease. The most frequent abnormalities are a rightward P-wave axis (greater than or equal to 70 degrees) and a rightward QRS axis (greater than or equal to 90 degr... | general pathological conditions |
Immunotherapy. Neuroblastoma as a model. Combinations of aggressive therapy and radiotherapy directed at the primary tumor site as well as dose intensive chemotherapy against metastases can effectively induce complete remissions in patients with stage IV neuroblastomas. By virtue of its tumor specificity, the use of im... | neoplasms |
Skin manifestations in congenital deficiency of leucocyte-adherence glycoproteins (CDLG). In congenital deficiency of leucocyte-adherence glycoproteins (CDLG) there is an immunodeficiency with impaired leucocyte function and cutaneous and extracutaneous infections occur. In more than 30% of cases the condition has a fa... | general pathological conditions |
Immunohistochemical demonstration of keratin in ameloblastoma as an indication of tumor differentiation. Keratin expression was studied immunohistochemically in 27 ameloblastomas using polyclonal antibody against wide-spectrum keratins (TTL) and monoclonal antibodies against lower- and higher-molecular-weight keratins ... | neoplasms |
Immune functions during treatment of growth hormone-deficient children with biosynthetic human growth hormone. Immune functions, including cell surface markers, interleukin-2 receptor levels and responses of lymphocytes to mitogenic stimulation were evaluated in seven growth hormone deficient children ages 4-15 years, ... | general pathological conditions |
Quantitative echocardiographic analysis of global and regional left ventricular function: a problem revisited. We recorded two-dimensional echocardiograms simultaneously with the respiration measurements of 20 normal subjects and 20 patients with anterior myocardial infarction. The apical long-axis and four-chamber vie... | cardiovascular diseases |
Family history fails to identify many children with severe hypercholesterolemia. Optimal strategies for identifying children with hypercholesterolemia have not been established. Several groups have advocated that testing of serum cholesterol levels be limited to those children who have family histories of hyperlipidemi... | cardiovascular diseases |
Assessment of ventricular function with an ambulatory left ventricular function monitor. Changes in ventricular function caused by activities of daily living, including standing, walking, stair climbing, and mental stress, were evaluated using a radionuclide device that recorded left ventricular function on a beat-by-b... | cardiovascular diseases |
Morphological and histopathological aspects of aneurysms after patch aortoplasty for coarctation. Repair of coarctation of the aorta by synthetic patch grafting has been complicated by late aneurysm formation. These aneurysms differ macroscopically from atherosclerotic thoracic aortic dilatations. Specimens for microsc... | general pathological conditions |
A clinical study of acute gastrointestinal hemorrhage associated with various shock states. Gastrointestinal hemorrhage from stress ulceration is a life-threatening complication in a critically ill patient. We retrospectively studied 471 patients admitted to the Department of Traumatology of our hospital who developed ... | general pathological conditions |
Expression of the human nephron differentiation molecules in renal cell carcinomas. The authors tested frozen sections from 28 renal cell carcinomas (RCC)--21 clear, 1 eosinophilic, 4 basophilic, and 2 spindle-shaped cell type--with monoclonal antibodies (MAb) reacting against cytokeratin, vimentin, CD24, CALLA/CD10, v... | neoplasms |
Tension pneumothorax secondary to a gastropleural fistula in a traumatic diaphragmatic hernia. We report a case of tension pneumothorax due to a gastropleural fistula resulting from perforation of the stomach in a traumatic diaphragmatic hernia. Awareness of perforation of strangulated stomach or bowel in a diaphragmat... | general pathological conditions |
Tricuspid valve repair for tricuspid valve endocarditis: tricuspid valve "recycling". Tricuspid valve endocarditis traditionally has been treated with either valve excision or valve replacement. To avoid implantation of foreign material in an infected field, we have applied the principles of mitral valve repair to 4 pa... | cardiovascular diseases |
Postoperative hypertension: a prospective, placebo-controlled, randomized, double-blind trial, with intravenous nicardipine hydrochloride. Nicardipine hydrochloride, a new calcium channel blocker for intravenous use, has been compared with placebo in a prospective, randomized, double-blind trial on postoperative hypert... | general pathological conditions |
The leukocyte count: a predictor of hypertension. In an exploratory study of 1031 persons observed to progress from normotension to essential hypertension and 1031 matched subjects who remained normotensive, the initial leukocyte count (WBC) was found to be related to the development of hypertension, with risk increase... | cardiovascular diseases |
Elevated plasma beta-endorphin levels in patients with congestive heart failure Recent experimental studies show that the opioid system is important to the pathophysiology of cardiovascular impairment in congestive heart failure. Plasma beta-endorphin levels were measured in 37 patients with congestive heart failure an... | cardiovascular diseases |
Lipiodol computerized tomography: how sensitive and specific is the technique in the diagnosis of hepatocellular carcinoma? Computerized tomography (CT) following the intra-arterial injection of Lipiodol (Lipiodol-CT) was performed on 60 patients suspected of having a hepatocellular carcinoma (HCC). Four main patterns ... | neoplasms |
Coronary angioplasty requiring extraordinarily high balloon inflation pressure. Two cases are presented in which extraordinarily high balloon inflation pressures (20 and 17 atm) were required to successfully dilate a saphenous vein graft stenosis and a right coronary artery stenosis. The clinical application of high ba... | cardiovascular diseases |
Breast self-examination in relation to the occurrence of advanced breast cancer. Two hundred nine female enrollees of the Group Health Cooperative of Puget Sound who developed advanced-stage breast cancer during the period 1982-1988 were interviewed about their practice of breast self-examination (BSE), use of other br... | neoplasms |
Genetic mapping of "Lubag" (X-linked dystonia-parkinsonism) in a Filipino kindred to the pericentromeric region of the X chromosome. "Lubag" is an X-linked disorder causing dystonia and parkinsonism that has only been described in families from the Philippines, principally from the island of Panay. We have established ... | nervous system diseases |
Usefulness of labetalol in chronic atrial fibrillation. Beta-adrenergic blocking agents are useful in controlling excessive ventricular rate in chronic atrial fibrillation (AF) but often reduce exercise capacity. To investigate the advantage of labetalol--a unique beta blocker with alpha-blocking property--in chronic A... | cardiovascular diseases |
Spinal instability secondary to metastatic cancer. Fifty-five patients with severe pain from spinal instability secondary to metastatic cancer were referred to Hope Hospital, none being judged to be in a terminal condition. One patient had too extensive disease for surgery so 54 were treated by 55 spinal stabilisations... | nervous system diseases |
Multiple gunshot wounds of the head: an anthropological view. A decomposed body was judged at the scene to have two gunshot wounds of the thorax and three of the head. Confirmed at autopsy, the condition of the remains precluded conclusions about the precise nature of the defects. Preparation and reconstruction of the ... | general pathological conditions |
Chemoprotective effects of recombinant human IL-1 alpha in cyclophosphamide-treated normal and tumor-bearing mice. Protection from acute toxicity, hematologic effects, development of late mortality, and enhanced therapeutic efficacy. In this study, recombinant human IL-1 alpha (rhIL-1 alpha) was used to protect normal ... | neoplasms |
Cystic hygroma: massive recurrence in adult life. Cystic hygroma is considered a disease of childhood. It may appear for the first time in adult life but recurrence by that stage is rare and may present difficulties in diagnosis due to previous treatment. The authors present a case where early pharmacological intervent... | neoplasms |
Inconsistent response to divalproex sodium in hemichorea/hemiballism. We report 6 patients with hemichorea/hemiballism of vascular origin who were treated with divalproex sodium (Depakote). Four of 6 responded initially. Marked improvement was seen in 2 patients only and in 1 of these hemiballism recurred despite conti... | nervous system diseases |
An extracorporeal perfusion system to bridge pediatric liver transplant candidates. An extracorporeal liver perfusion system was designed to maintain cadaver livers in an oxygenated, normothermic state for bridging procedures for hepatic transplantation. Nonpulsatile high flow and pulsatile low flow blood are supplied ... | general pathological conditions |
Clinical characteristics and coronary angiographic findings of patients with unstable angina, acute myocardial infarction, and survivors of sudden ischemic death occurring during and after sport. The clinical characteristics and coronary angiographic findings of 42 well-conditioned subjects with an acute ischemic event... | general pathological conditions |
Prevalence of coronary heart disease in Scotland: Scottish Heart Health Study Data from 10,359 men and women aged 40-59 years from 22 districts in the Scottish Heart Health Study were used to describe the prevalence rates of coronary heart disease in Scotland in 1984-1986 and their relation to the geographical variatio... | cardiovascular diseases |
Peritoneal blastomycosis. Blastomycosis is a systemic fungal infection caused by Blastomyces dermatitidis. Involvement of the peritoneum is unusual, with only two previously reported cases that occurred in association with disseminated disease. A single case of histopathologically proven blastomycosis involving the per... | digestive system diseases |
Free protein S deficiency in a family with venous thrombosis. Inherited deficiencies of protein S, an inhibitor of the coagulation system, are now recognized as occurring at least twice as frequently as antithrombin III deficiency in patients with venous thrombosis. Protein S is present in plasma in a complexed form, w... | cardiovascular diseases |
Pelvic pain and infections. Infectious etiologies of both acute and chronic pelvic pain are common and may involve multiple organ systems. In the evaluation of the acute pain, it is important to remember that rapidity of diagnosis is important because of the possibility of significant morbidity and even death if a cond... | general pathological conditions |
Dependence among host response parameters used to diagnose urinary tract infection. The host-response parameters fever, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) are activated in concert by cytokines such as interleukin-6 (IL-6). Il-6 is secreted in response to Escherichia coli infection of the... | general pathological conditions |
Laser placement in noncontact Nd:YAG cyclophotocoagulation. We treated 40 eyes of 40 patients by using noncontact transscleral Nd:YAG cyclophotocoagulation to determine whether treatment 1.5 or 3.0 mm posterior to the corneoscleral lumbus was preferable. Patients were randomly assigned to one of the treatment groups, a... | general pathological conditions |
A preliminary report of arthroscopic findings following acute condylar trauma Standard therapy in orthopedics dictates that joints with suspected hemarthrosis be considered for irrigation or exploration, especially when immobilization is part of the treatment plan. In this preliminary report, 14 patients who had condyl... | general pathological conditions |
Simultaneous or staged bilateral total knee replacements in rheumatoid arthritis. A prospective study. In a prospective study of 100 knee arthroplasties in patients with rheumatoid arthritis, simultaneous bilateral surgery was compared with staged bilateral replacements. All patients had improved function following the... | general pathological conditions |
Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus. Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been iden... | general pathological conditions |
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