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Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. We compared the activity and physiologic effects of cardiac angiotensin converting enzyme (ACE) using isovolumic hearts from ... | cardiovascular diseases |
Effects of differential touch on nervous system arousal of patients recovering from cardiac disease. Previous research suggests that the neural properties of certain types of touch as well as their perceived significance to the disease state may be related to heightened activation of the nervous system. In this study t... | cardiovascular diseases |
Congenital angiotropic lymphoma (intravascular lymphomatosis) of the T-cell type. The autopsy of a stillborn infant showed an extensive intravascular proliferation of atypical cells throughout the body. There was no infiltration by these cells of the parenchyma of the bone marrow, lymph nodes, or thymus. By histochemis... | general pathological conditions |
Posterior chamber intraocular lens implantation in eyes with inactive and active proliferative diabetic retinopathy. We reviewed the records of 2,100 consecutive eyes that had undergone extracapsular cataract extraction with intraocular lens implantation between January 1981 and December 1989. Of these eyes, 21 had ina... | general pathological conditions |
Acute sensorineural deafness in Lassa fever A prospective audiometric evaluation of 69 hospitalized febrile patients in Sierra Leone, West Africa, revealed a sensorineural hearing deficit (SNHD) in 14 (29%) of 49 confirmed cases of Lassa fever and in 0 of 20 febrile controls. An SNHD was present in nine (17.6%) of 51 p... | nervous system diseases |
Primary de novo adenocarcinoma of the colon measuring 8 mm in diameter with lymph node metastases. Report of a case. Colonic adenocarcinomas measuring less than 10 mm are rare. Herein, we report a carcinoma measuring 8 mm in diameter associated with subserosal extension through a "locus minoris resistentiae" and metast... | neoplasms |
National Education Programs Working Group report on the management of patients with hypertension and high blood cholesterol. Cardiovascular diseases are responsible for nearly one of every two deaths in the United States, and have been estimated to cost more than $127 billion annually. Epidemiologic data have shown tha... | cardiovascular diseases |
The role of diencephalic pathology in human memory disorder. Evidence from a penetrating paranasal brain injury. A patient (B.J.) is reported who developed severe memory impairment following a penetrating brain injury caused by a snooker cue which entered through his left nostril into the basal regions of the brain. In... | nervous system diseases |
Lack of effect of pregnancy on outcome of melanoma. For The World Health Organisation Melanoma Programme To determine the effect of pregnancy on prognosis in melanoma we investigated 388 women treated for stage 1 primary cutaneous disease during their childbearing years. 85 women had been treated before any pregnancy, ... | neoplasms |
Status epilepticus in infancy and childhood. Status epilepticus implies a prolonged seizure or recurrent seizures with persistent decreased consciousness, lasting at least 30 minutes. Both convulsive and nonconvulsive forms exist, either of which may lead to death or additional neurologic deficit. Therapy involves care... | general pathological conditions |
Gastrointestinal bleeding in a 15 month old male. A presentation of Munchausen's syndrome by proxy. Munchausen's syndrome by Proxy is a well-described entity that may not always be immediately considered in a complicated case. We describe this syndrome being portrayed through the guise of gastrointestinal bleeding in a... | general pathological conditions |
Predicting the appropriate use of carotid endarterectomy, upper gastrointestinal endoscopy, and coronary angiography BACKGROUND AND METHODS. In a nationally representative population 65 years of age or older, we have demonstrated that about one quarter of coronary angiographies and upper gastrointestinal endoscopies an... | cardiovascular diseases |
Melanocytic hyperplasia of the oral mucosa. Lesions that exhibit melanocytic hyperplasia are uncommon in the oral mucosa. They are even more rare than the various morphologic types of nevomelanocytic lesions. This article reports the clinicopathologic features of oral lesions diagnosed as lentigo simplex, junctional le... | general pathological conditions |
Lack of cutaneous hyperemia in response to insulin-induced hypoglycemia in IDDM. Cutaneous blood flow was measured with the laser Doppler technique and by recording cutaneous O2 tension on the forearm and forehead in nine young adult patients with insulin-dependent diabetes mellitus (IDDM) and nine sex- and age-matched... | cardiovascular diseases |
Physiological induction and reversal of focus formation and tumorigenicity in NIH 3T3 cells [published erratum appears in Proc Natl Acad Sci U S A 1991 Apr 15;88(8):3510] NIH 3T3 cells undergo morphological transformation in response to conditions of constrained growth, such as occur in low serum concentrations or at c... | general pathological conditions |
Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis. The nm23 gene was identified in murine melanoma cells, in which its expression is associated with the cells' metastatic potential. Expression of nm23 has been detected in human breast tumors by means of hybridization ... | neoplasms |
Changing arteriosclerotic disease patterns and management strategies in lower-limb-threatening ischemia. From January 1, 1974 to December 31, 1989, we treated 2829 patients with critical lower-extremity ischemia. In the last 5 years, 13% of patients had therapeutically significant stenoses or occlusions above and below... | cardiovascular diseases |
Hypercapnic respiratory failure due to L-tryptophan-induced eosinophilic polymyositis. A 24-year-old man presenting with fever, rash, and myalgias subsequently developed hypercapnic respiratory failure and severe limb muscle weakness. Muscle biopsy revealed eosinophilic myositis, due to the ingestion of large quantitie... | general pathological conditions |
Anticardiolipin antibodies: a study of frequency in TIA and stroke. We undertook a prospective study of consecutive patients to determine the frequency of elevated IgG and IgM anticardiolipin antibodies in transient ischemic attack and ischemic stroke and found elevated IgG antibodies in 8.2% (9 of 110) and IgM in 9.1%... | nervous system diseases |
Retroperitoneal air after routine hemorrhoidectomy. Report of a case. Retroperitoneal air as a complication after routine hemorrhoidectomy has not been reported in the literature. This occurred recently after hemorrhoidectomy in a 34-year-old patient receiving glucocorticoid therapy for rheumatoid arthritis. Adverse st... | general pathological conditions |
Secretin provocation test in the diagnosis of Zollinger-Ellison syndrome. The secretin stimulation test has become the preferred provocative test in suspected cases of Zollinger-Ellison syndrome. A pure secretin preparation, a gastrin-specific radioimmunoassay, and an appropriate sampling sequence are important for the... | neoplasms |
Philadelphia chromosome and monosomy 7 in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study. During an 8-year period, 3,638 children from institutions of the Pediatric Oncology Group (POG) were diagnosed with acute lymphoblastic leukemia (ALL). Fifty-seven patients had Philadelphia chromosome-pos... | neoplasms |
Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential. The experimental metastatic potential of 13762NF mammary adenocarcinoma clone MTLn3 was tested after pretreatment in serum-free medium containing transforming growth factor (TGF) beta 1 at 0-5000 pg/ml. Lung coloni... | general pathological conditions |
Lipomatous hypertrophy of the interatrial septum: an unusual intraoperative finding. Lipomatous hypertrophy of the interatrial septum was an incidental finding in a man of 45 undergoing coronary artery bypass grafting for unstable angina. He was not overweight and did not have any rhythm disturbances. The diagnosis was... | general pathological conditions |
Delivery dependence of early proximal bicarbonate reabsorption in the rat in respiratory acidosis and alkalosis. In the intact rat kidney, bicarbonate reabsorption in the early proximal tubule (EP) is strongly dependent on delivery. Independent of delivery, metabolic acidosis stimulates EP bicarbonate reabsorption. In ... | general pathological conditions |
Retinal sensitivity in acute hypoglycemia. We measured retinal threshold sensitivity via automated computerized static perimetry in predetermined meridians in euglycemic diabetic subjects and in the same subjects during insulin-induced hypoglycemia. During periods of reduced blood glucose levels, decreased retinal sens... | general pathological conditions |
Patients at risk for cardiac death late after aortic valve replacement. A total of 100 patients aged 24 to 78 years were screened prospectively a mean of 71 months after aortic valve replacement for the presence of left ventricular hypertrophy (LVH) on the ECG (Estes scores greater than or equal to 5.0) and for repetit... | general pathological conditions |
Toxic shock syndrome after inguinal hernia repair. Report of a case with patient survival. A 40-year-old man developed fulminant multisystem failure several days after elective repair of an inguinal hernia. Toxic shock syndrome (TSS) was diagnosed. There was, however, no evidence of wound infection at the time of multi... | digestive system diseases |
Neuroanatomic differences between dyslexic and normal readers on magnetic resonance imaging scans. The areas of six bilateral brain segments in the right and left hemispheres, on a horizontal brain section, and the area of subdivisions of the corpus callosum, on a midsagittal brain section, were measured on magnetic re... | nervous system diseases |
Lyme disease: recommendations for diagnosis and treatment The incidence and the endemic range of Lyme disease in the United States have increased steadily since the disease was originally recognized in Lyme, Connecticut, in 1975. Because of the varied clinical manifestations of this illness and the use of unstandardize... | cardiovascular diseases |
Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. The Study of Perioperative Ischemia Research Group BACKGROUND. Adverse cardiac events are a major cause of morbidity and mortality after noncardiac surgery. It is necessary to determine the predic... | cardiovascular diseases |
The neural substrate of memory impairment demonstrated by the intracarotid amobarbital procedure. The intracarotid amobarbital sodium (Amytal) procedure (IAP) was performed for 46 patients with temporal lobe epilepsy (21 with left seizure foci; 25 with right seizure foci). After anteromedial temporal lobectomy, neurona... | general pathological conditions |
Steroid cell tumor of the ovary in a child. An 8-year-old girl exhibited severe, progressive virilization of 2 years' duration associated with markedly elevated circulating testosterone concentrations. Based on her initial clinical presentation and results of a chemical evaluation, she was originally thought to have no... | neoplasms |
When is echocardiography unreliable in patients undergoing catheterization for pediatric cardiovascular disease? Technologic advances in echocardiography (e.g., better spatial resolution, Doppler, and color flow mapping) have improved our ability to demonstrate anatomy and physiology in previously problematic condition... | cardiovascular diseases |
Vesicular changes in the myopathies of AIDS. Ultrastructural observations and their relationship to zidovudine treatment. Six patients with AIDS and AIDS related complex (ARC) who developed neuromuscular symptoms associated with vesicular changes in muscle fibres are reported. Two patients in the advanced stages of AID... | general pathological conditions |
Prevention of cardiovascular disease: risks and benefits of aspirin. Aspirin has been tested for its benefit in preventing cardiovascular disease in randomized trials in three categories of patients. In secondary prevention among those with a history of myocardial infarction (MI), stroke or transient cerebral ischemia,... | cardiovascular diseases |
Methyl prednisolone in double-lumen gel-saline submuscular mammary prostheses: a double-blind, prospective, controlled clinical trial. At the time of immediate breast reconstruction with submuscular implants, 76 consecutive patients (89 breasts) were randomized into two groups. One received a gel-saline, double-lumen i... | general pathological conditions |
Diagnosis of popliteal artery entrapment syndrome: the role of duplex scanning. The authors present a new diagnostic procedure to quickly and noninvasively diagnose the popliteal artery entrapment syndrome. A large personal experience on the surgical treatment of such a disease (29 cases in 22 patients) allowed us to f... | general pathological conditions |
Unusual variants of adrenal pseudocysts with intracystic fat, myelolipomatous metaplasia, and metastatic carcinoma. Five previously unreported cases of adrenal pseudocysts are described that demonstrate a wider range of histologic appearances than has been previously recognized in these lesions. One pseudocyst removed ... | neoplasms |
Association of immunoglobulin Km and Gm allotypes with specific antinuclear antibodies and disease susceptibility among connective tissue disease patients. The distribution of the immunoglobulin Km(1) and Gm phenotypes was examined in patients with connective tissue diseases, including systemic lupus erythematosus, mix... | general pathological conditions |
Changes in surgical treatments: the example of hysterectomy versus conization for cervical carcinoma in situ. From 1969 through 1985, 4584 women in the state of New Mexico were diagnosed with carcinoma in situ of the cervix. Of these women, 65.5% underwent hysterectomy while 31.1% had a conservative therapy (primarily ... | neoplasms |
Effect of 17 beta-estradiol on the growth of an estrogen receptor-positive human esophageal carcinoma cell line. Receptors for estrogen and for androgen in the nucleus and cytosol (ERn, ERc, ARn, and ARc, respectively) were studied on two newly established human esophageal carcinoma cell lines, ES-25C and ES-8C. ES-25C... | neoplasms |
Nevus flammeus. Discordance in monozygotic twins. Nevus flammeus has been described as an inherited vascular anomaly. We report two cases of nevus flammeus, each appearing in one of two monozygotic twins. This finding supports the idea that nevus flammeus results from embryologic mishap rather than genetic transmission... | neoplasms |
Neurologic complications of cardiac transplantation. Between 1984 and 1989, orthotopic cardiac transplantations were done in 90 patients from 10 to 65 years of age for end-stage, refractory congestive cardiomyopathy. Two patients had had ischemic strokes 5 months and 18 years, respectively, before transplantation. Six ... | general pathological conditions |
Risk of cancer death in first-degree relatives of patients with hereditary non-polyposis cancer syndrome (Lynch type II): a study of 130 kindreds in the United Kingdom. To estimate the relative risks of cancer in first-degree relatives of index patients, 130 pedigrees of dominantly inherited Lynch type II cancer family... | neoplasms |
Simultaneous hepatoblastoma in identical male twins. Identical male twin infants who in 1987 presented with hepatoblastoma at the age of 7 months are reported. Twin B was admitted for investigation due to enlarged liver and spleen. He was found to have an inoperable hepatoblastoma of fetal type and was treated with che... | general pathological conditions |
Hypersensitivity reactions to epipodophyllotoxins in children with acute lymphoblastic leukemia. The incidence, clinical characteristics, and outcome of hypersensitivity reactions to teniposide (VM-26), etoposide (VP-16), or both were determined in 108 children with acute lymphoblastic leukemia (ALL) treated with a con... | neoplasms |
Home blood pressure readings in borderline hypertensive patients. Home blood pressure monitoring can provide valuable information for physicians managing borderline hypertensive patients. This study was conducted to compare office and home blood pressures in 36 borderline hypertensive subjects, and to determine the acc... | cardiovascular diseases |
Optimal interpretation of the supine exercise electrocardiogram in patients with right bundle branch block. A detailed analysis of the exercise ECG was performed in 82 patients with right bundle branch block who underwent supine exercise equilibrium radionuclide angiography. The sensitivity and specificity of each indi... | cardiovascular diseases |
Portacaval shunt versus endoscopic sclerotherapy in the elective treatment of variceal hemorrhage. Eighty-two consecutive Child-Campbell class A and B cirrhotic patients were included in a prospective controlled trial to assess the efficacy and safety of portacaval anastomosis vs. endoscopic sclerotherapy as elective t... | digestive system diseases |
Revision total knee arthroplasty for failed unicompartmental replacement. The results in nineteen patients (twenty-one knees) who had a failed unicompartmental knee replacement followed by a revision total knee arthroplasty were evaluated. There were twelve excellent, four good, one fair, and two poor results. The inte... | general pathological conditions |
Percutaneous puncture of a nondeflatable coronary artery angioplasty balloon. We report a case in which a balloon catheter became permanently inflated in a coronary artery saphenous vein bypass graft. While still inflated, the balloon was forcibly withdrawn from the graft into the external iliac artery and successfully... | general pathological conditions |
Heparin-induced thrombocytopenia in patients who undergo open heart surgery. To determine whether heparin-dependent antiplatelet antibodies (HAAb) have an effect on morbidity and/or mortality rates, we reviewed the cases of 3438 patients who underwent open heart surgery from 1981 to 1989. Forty-six patients (1.3%) had ... | general pathological conditions |
Diltiazem overdose: pharmacokinetics of diltiazem and its metabolites and effect of multiple dose charcoal therapy. We describe a 38 year-old female who ingested 900 mg of diltiazem. She experienced hypotension, bradycardia and heart block but responded well to supportive care that included normal saline infusion and v... | cardiovascular diseases |
Effect of ethanol on the efficacy of nasal continuous positive airway pressure as a treatment for obstructive sleep apnea. The effect of ethanol ingestion on the efficacy of nasal continuous positive airway pressure (nasal CPAP) as a treatment for the obstructive sleep apnea (OSA) syndrome was studied in ten obese male... | nervous system diseases |
Bronchoalveolar carcinoma: factors affecting survival. One hundred thirty-four consecutive patients (65 men and 69 women) underwent pulmonary resection for bronchoalveolar carcinoma. Mean age was 65 years. Lobectomy was done in 100 patients, pneumonectomy in 10, segmentectomy in 5, and wedge excision in 19. Only 10 pat... | neoplasms |
Lung cancer risk associated with cancer in relatives. Family history data from an incident case-control study of lung cancer conducted in the Texas Gulf Coast region between 1976 and 1980 were analyzed to evaluate the contribution of cancer in first-degree relatives to lung cancer risk. Odds ratios (OR) increased sligh... | neoplasms |
Nonmucous glycoproteins as pronucleating agents. Cholesterol crystallization-promoting factors probably play an important role in the pathogenesis of gallstone disease. We have isolated one of the factors involved by using lectin-affinity chromatography. A potent promoting activity binds to concanavalin A-Sepharose. Th... | digestive system diseases |
Effect of omeprazole and high doses of ranitidine on gastric acidity and gastroesophageal reflux in patients with moderate-severe esophagitis Thirty to fifty percent of patients with reflux esophagitis fail to heal after treatment with conventional doses of H2-receptor antagonists, whereas omeprazole administration ind... | digestive system diseases |
Hypoxia-induced in vivo sickling of transgenic mouse red cells. To develop an animal model for sickle cell anemia, we have created transgenic mice that express a severe naturally occurring human sickling hemoglobin, Hb S Antilles. Due to its low solubility and oxygen affinity, Hb S Antilles has a greater propensity to ... | general pathological conditions |
Coronary sinus occlusion: effect on ischemic left ventricular dysfunction and reactive hyperemia. Pressure-controlled intermittent coronary sinus occlusion (PICSO) has been shown to reduce experimental infarct size. To examine the role of PICSO in limiting the consequences of brief ischemia on left ventricular function... | cardiovascular diseases |
Fascinating rhythm: a primer on chaos theory and its application to cardiology. Nonlinear dynamics is an exciting new way of looking at peculiarities that in the past have been ignored or explained away. We have attempted to give a general introduction to the basics of the mathematics, applications to cardiology, and a... | general pathological conditions |
The stroke syndrome of striatocapsular infarction. Striatocapsular infarction has recently been described as a distinct stroke entity and forms an important subgroup of subcortical infarctions. In a prospective study of 50 consecutive patients over a 10 yr period with this syndrome, clinical and neuropsychological feat... | nervous system diseases |
The classification and diagnosis of headache disorders. Headache disorders recently have been reclassified, and new operational diagnostic criteria assist in making the correct diagnosis. These diagnostic criteria have been accepted worldwide. | nervous system diseases |
Hypersensitivity reactions to epipodophyllotoxins in children with acute lymphoblastic leukemia. The incidence, clinical characteristics, and outcome of hypersensitivity reactions to teniposide (VM-26), etoposide (VP-16), or both were determined in 108 children with acute lymphoblastic leukemia (ALL) treated with a con... | general pathological conditions |
Cardiovascular responses to arm cranking and FNS-induced leg exercise in paraplegics. Twelve spinal cord-injured males performed arm-crank exercise (ACE) with and without concurrent functional neuromuscular stimulation (FNS) of paralyzed leg muscles to investigate the hypothesis that FNS would augment cardiovascular pe... | nervous system diseases |
Flexion-extension views in the evaluation of cervical-spine injuries. STUDY OBJECTIVE: To determine the efficacy of flexion-extension (F/E) cervical-spine radiographs in detecting acute cervical-spine instability in emergency patients. DESIGN: We retrospectively reviewed the charts of 141 consecutive trauma patients wh... | nervous system diseases |
Ototoxicity of cis-platinum and its relationship to eye colour. The following hypothesis is presented: that the susceptibility of an individual patient to hearing loss as a result of cis-platinum administration can be predicted on the basis of eye colour. The rationale is that the melanin content of the inner ears is r... | general pathological conditions |
Morphological and biochemical changes in gastric mucosa of aging rats. Although previous data from this laboratory have indicated that aging is associated with increased gastric mucosal proliferative activity, no direct assessment of proliferative potential of the tissue has been made during aging. In order to assess t... | general pathological conditions |
Resolution of the adult respiratory distress syndrome following colectomy and liver transplantation. A 32-year-old woman with liver failure from end-stage cirrhosis and ulcerative colitis developed septicemia and severe ARDS. Subtotal colectomy and a successful liver transplantation resulted in complete resolution of t... | digestive system diseases |
Thermal balance and tremor patterns during epidural anesthesia. Five healthy, nonpregnant volunteers were studied before and after induction of lumbar epidural anesthesia to determine the cause of central hypothermia during epidural anesthesia. Cutaneous heat loss was measured from 10 area-weighted sites using thermal ... | general pathological conditions |
Association of Helicobacter pylori infection with dyspeptic symptoms in patients undergoing gastroduodenoscopy. PURPOSE: To determine the prevalence of Helicobacter pylori in patients with non-ulcer dyspepsia and ulcer disease as well as in a control population undergoing endoscopic retrograde cholangiopancreatography ... | general pathological conditions |
Lymph node metastasis from papillary-follicular thyroid carcinoma in young patients. A total of 117 patients under 20 years of age with papillary and/or follicular thyroid cancer presented to the M. D. Anderson Cancer Center between 1949 and 1987. The most common presenting symptom was a cervical mass. Twenty percent o... | neoplasms |
Systolic hypertension in the elderly: reasons not to treat. Isolated systolic hypertension in the elderly is associated with increased morbidity and mortality. Accurate measurement of blood pressure in older patients is difficult. Therapy can be associated with various complications, and the special problems of the eld... | cardiovascular diseases |
Ventricular ectopy: significance and management. Ventricular ectopy is a normal variant of cardiac rhythm, and its significance in an individual is related to cardiac risk factors and the presence or absence of heart disease. Although there is good evidence in many forms of heart disease that complex VEBs indicate a hi... | general pathological conditions |
Congenital duodenal diaphragm: conversion of stable chronic symptoms to subacute gastric outlet obstruction by penetrating foreign body. Congenital duodenal diaphragms (CDD) are rare lesions that usually become symptomatic and require surgery in childhood. We report a patient, who, although symptomatic since early chil... | digestive system diseases |
Proliferation and substrate effects on endothelial cell thrombogenicity. The effects of the cellular differentiation status and the adhesive-substrate on endothelial cell function in cell culture were measured with an enzyme based assay of surface thrombogenicity. A solid plastic, microporous polymeric, and fibronectin... | general pathological conditions |
Diagnostic significance of flow separation within the carotid bifurcation demonstrated by digital subtraction angiography. The presence of an area of reversed blood flow due to flow separation in the interval carotid artery is a normal finding in Doppler ultrasound studies in vivo as well as in model carotid bifurcatio... | cardiovascular diseases |
Patterns of dyspepsia in patients with no clinical evidence of organic diseases. We studied 2000 dyspeptic patients with no obvious signs of organic disease at their first examination, in order to (1) verify how many diagnoses of idiopathic dyspepsia had really been made after exhaustive diagnostic procedures and (2) e... | general pathological conditions |
Drug therapy for ventricular tachyarrhythmias: how many electropharmacologic trials are appropriate? To determine how many electropharmacologic drug trials should be performed to select therapy for patients with ventricular tachyarrhythmias, the outcome of 150 consecutive patients with inducible ventricular tachyarrhyt... | general pathological conditions |
Seizures and other neurologic sequelae of bacterial meningitis in children. BACKGROUND. Although the mortality rate among children with bacterial meningitis has decreased dramatically in recent decades, some patients are left with neurologic sequelae. It has not been clearly established which features of the acute illn... | nervous system diseases |
A case of massive true thymic hyperplasia with non-Hodgkin's lymphoma. A case of massive true thymic hyperplasia with non-Hodgkin's lymphoma of the mediastinum is reported in a 14-year-old boy. Computed tomographic scan of the chest showed a mass of the anterior mediastinum and conspicuous swelling of the lymph nodes i... | neoplasms |
Mechanism of intermittent preexcitation in the Wolff-Parkinson-White syndrome. The concept of electronically mediated conduction across an inexcitable gap. A man with intermittent preexcitation in the Wolff-Parkinson-White syndrome is reported. Once a sinus impulse was blocked in the accessory pathway, the block (ie, l... | cardiovascular diseases |
Stress and sudden death. The case of the long QT syndrome. The idiopathic long QT syndrome (LQTS) represents a unique clinical example of stress-related sudden cardiac death. LQTS is characterized by the association of several distinctive electrocardiographic features, among which prolongation of the QT interval is the... | general pathological conditions |
The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel. Glanzmann thrombasthenia is an autosomal recessive bleeding disorder characterized by a decrease or absence of functional platelet glycoprotein (GP) IIb-IIIa (alpha IIb beta 3) integrin receptors. Although thromb... | general pathological conditions |
Changes in ventricular fibrillation threshold during the development of perinephritic hypertension. Established hypertension is associated with enhanced susceptibility to life-threatening arrhythmias. However, little is known about the effects of the development of hypertension on the electro-physiological properties o... | general pathological conditions |
Adjuvant, specific, active immunotherapy for resectable squamous cell lung carcinoma: a 5-year survival analysis. In 1976 Stewart et al. (Annals of the New York Academy of Sciences 277:436-466) reported the effectiveness of adjuvant specific active immunotherapy of lung carcinoma in improving the postoperative survival... | neoplasms |
Characterization of the effect of two 4-methyl piperidine derivatives of hemicholinium-3, A-4 and A-5, on choline transport. A-4 and A-5 are tertiary and N-methyl quaternary 4-methylpiperidine analogs of hemicholinium-3 (HC-3). Previous work in this laboratory has shown A-4 and A-5 to be inhibitors of the sodium-depend... | neoplasms |
New developments in cardiopulmonary resuscitation. Since the last revision of the American Heart Association's guidelines in 1985, several new developments of clinical importance have occurred in the field of cardiopulmonary resuscitation. These include enhanced access to and earlier use of defibrillation, the use of h... | cardiovascular diseases |
Persistent mullerian duct syndrome. Persistent mullerian syndrome is rare. A case of phenotypically normal male with persistent mullerian structures that consisted of a bicornuate uterus, fallopian tubes, and upper third of the vagina is reported. These unusual structures were found in association with bilateral crypto... | general pathological conditions |
Vagal modulation of the rate-dependent properties of the atrioventricular node. Vagal effects on atrioventricular (AV) nodal conduction are accentuated by increases in heart rate. To establish the mechanism of these rate-dependent negative dromotropic actions, we studied the properties governing AV nodal adaptation to ... | general pathological conditions |
Melanocytic hyperplasia of the oral mucosa. Lesions that exhibit melanocytic hyperplasia are uncommon in the oral mucosa. They are even more rare than the various morphologic types of nevomelanocytic lesions. This article reports the clinicopathologic features of oral lesions diagnosed as lentigo simplex, junctional le... | neoplasms |
Immunotherapy in acute arsenic poisoning. We investigated the use of immunotherapy on the treatment of sodium arsenite toxicity. Female balb/c mice injected with arsanilic acid conjugated to a carrier protein (ovalbumin) were shown to produce antibodies (arsenic reactive serum, ARS) reactive with arsanilic acid and sod... | general pathological conditions |
Relation between flow grade after thrombolytic therapy and the effect of angioplasty on left ventricular function: a prospective randomized trial. Recent intervention trials during myocardial infarction demonstrated no benefit from emergency angioplasty after thrombolytic therapy when compared with either delayed percu... | cardiovascular diseases |
Recent advances in etoposide therapy for non-small cell lung cancer. Non-small cell lung cancer (NSCLC) continues to be a major health problem in the US. In 1990, approximately 120,000 new cases will be diagnosed, and the majority of these patients will have either unresectable disease or resected disease that has a re... | neoplasms |
Systemic preoperative chemotherapy with cisplatin, methotrexate and vinblastine for locally advanced bladder cancer: local tumor response and early followup results. A total of 44 patients with infiltrating, locally advanced bladder cancer (stages T 3a-b, T 4a-b and N+/N0) were treated with the systemic chemotherapy re... | neoplasms |
Approach to diagnosis of meningitis. Cerebrospinal fluid evaluation. CSF evaluation is the single most important aspect of the laboratory diagnosis of meningitis. Analysis of the CSF abnormalities produced by bacterial, mycobacterial, and fungal infections may greatly facilitate diagnosis and direct initial therapy. Ba... | nervous system diseases |
Serial magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy. We prospectively performed magnetic resonance imaging (MRI) studies during the neonatal period, and at 4 and 8 months of age, on 15 term infants with hypoxic-ischemic encephalopathy, and compared the results with their neurodevelopmental out... | neoplasms |
The health belief model: predicting compliance and dropout in cardiac rehabilitation. We investigated the health belief model and the health locus of control constructs as predictors of group membership (compliers or dropouts) with cardiac rehabilitation and whether they added predictive utility to routinely assessed p... | cardiovascular diseases |
Complete follow-up and evaluation of a skin cancer screening in Connecticut. On May 21, 1988, 251 persons were screened for skin cancer in New Haven, Connecticut. A total body skin examination was performed on 98% of the participants. On the basis of follow-up of 93% of persons with positive screens for basal cell carc... | neoplasms |
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