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Acute osteomyelitis in children. Reassessment of etiologic agents and their clinical characteristics. One hundred thirty-five children with acute osteomyelitis were identified by chart review during a 7-year period, January 1, 1980, through December 31, 1986. Bacteriologic causes were detected in 75 (55%) of the patien...
general pathological conditions
Isotonic high-sodium oral rehydration solution for increasing sodium absorption in patients with short-bowel syndrome. We compared the effect of a standard oral rehydration solution and a high-sodium polymeric-glucose solution on sodium absorption in short-bowel syndrome. Six patients with high jejunostomy were tested ...
general pathological conditions
Management of penile gunshot wounds. The management of 10 cases of penile gunshot wounds treated at Henry Ford Hospital from 1982 to 1986 is reviewed. All patients were assaulted by low velocity weapons (handguns). Eight patients had associated injuries, predominantly to the genital region (thigh, pubis, and scrotum). ...
general pathological conditions
Pseudo pre-excitation with concertina effect in idioventricular tachycardia. The concertina effect is a phenomenon where the QRS complexes reflect alternating phases of gradual widening and narrowing. This is most commonly due to ventricular pre-excitation, and the changes in QRS morphology are due to variability of th...
cardiovascular diseases
Preclinical pharmacology of celiprolol: a cardioselective beta-adrenergic antagonist and mild vasodilator. Celiprolol is a new antihypertensive agent that represents a new generation of beta-blockers. It combines cardioselective beta-adrenergic antagonism (beta 1) with a mild vasodilation via vasoselective beta-adrener...
cardiovascular diseases
Adenomatous polyp of the fallopian tube. A case report. Benign epithelial lesions of the fallopian tube are rare. An adenomatous polyp of the fallopian tube was discovered incidentally at laparotomy.
neoplasms
Recurrence of acoustic neurilemoma as a malignant spindle-cell neoplasm. Case report. A 75-year-old man presented with a right cerebellopontine angle tumor 11 months after complete macroscopic resection of a right acoustic neurilemoma. Histological examination of the recurrent tumor showed a malignant spindle-cell neop...
neoplasms
Rigid spine syndrome with respiratory failure. The pathogenesis and therapy of respiratory failure in the rigid spine syndrome are discussed in two cases who improved with respiratory assistance. In both cases, the partial pressures of oxygen and carbon dioxide were reversed in arterial blood gas analysis and %VC was l...
nervous system diseases
Myocardial magnesium: relation to laboratory and clinical variables in patients undergoing cardiac surgery. Magnesium concentration was measured in the right atrial appendage of 100 patients undergoing cardiac surgery and associations with serum and mononuclear blood cell magnesium, other laboratory values and patient ...
cardiovascular diseases
Lugol stain for intraoperative determination of the proximal surgical margin of the esophagus. An adequate proximal surgical margin is difficult to determine particularly in cases of esophageal carcinoma with surrounding intraepithelial invasion. We report here readily facilitated intraoperative approaches for detectio...
neoplasms
Inflammatory myofibroblastic tumor (plasma cell granuloma). Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Twenty cases of inflammatory myofibroblastic tumor (IMT) were studied; 19 involved the lung and 1 the esophagus only. The patients' ages ranged from 3 to 72 years. T...
general pathological conditions
Characterization of herpes simplex virus type 2 latency-associated transcription in human sacral ganglia and in cell culture. The ability of herpes simplex virus type 2 (HSV-2) to establish latency in and reactivate from sacral dorsal root sensory ganglia is the basis for recurrent genital herpes. The expression of HSV...
general pathological conditions
Benign thyroid hyperplasia presenting as bilateral vocal cord paralysis. Complete remission following surgery. A 52-year-old woman developed respiratory arrest on two separate occasions that required mechanical ventilation. Fiberoptic bronchoscopy demonstrated bilateral vocal cord paralysis, and a CT scan of the neck d...
general pathological conditions
Developmental regulation of granulocytic cell binding to hemonectin. Hemonectin (HN), a component of the bone marrow (BM) extracellular matrix which promotes adhesion of cells in the granulocytic lineage, was purified to near homogeneity and tested for its ability to mediate attachment of normal and leukemic cells of g...
neoplasms
Early 24-hour blood pressure elevation in normotensive subjects with parental hypertension Subjects with a family history of parental hypertension are reported to have a slightly higher office blood pressure in the prehypertensive stage. Whether this reflects a hyperreactivity to blood pressure measurement or a more pe...
cardiovascular diseases
The use of cytochemical procedures in the diagnosis and management of acute and chronic myeloid leukemia. The use of Wright-Giemsa-stained smears alone for the classification of acute leukemias often proves unsatisfactory. Some cases of M1, M5a, M7, and L2 are morphologically similar. In such cases, cytochemical stains...
neoplasms
Diagnostic value of DNA analysis in effusions by flow cytometry and image analysis. A prospective study on 102 patients as compared with cytologic examination One hundred twenty-six effusion samples from 102 patients were examined by cytology and flow cytometry (FCM). Overall, there was an 84% correlation between cytol...
general pathological conditions
Ethanol causes accelerated G1 arrest in differentiating HL-60 cells. The effects of clinically relevant ethanol concentrations on myeloid differentiation in the HL-60 cell promyelocytic leukemia line have been studied. The exposure of noninduced stem cells to 60 mM ethanol results in an increase in G1 cells, but there ...
neoplasms
Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. The usefulness of high-frequency stimulation of the ventral intermediate nucleus (Vim) as the first neurosurgical procedure in disabling tremor was assessed in 26 patients with Parkinson's disease and 6 with essential t...
general pathological conditions
Coarctation of the aorta and post-stenotic aneurysm formation. Despite earlier angiography, post-stenotic aneurysm of the aorta was an unexpected finding at operation in two patients with coarctation. One aneurysm was found in an intercostal artery in a 19 year old man and the other was a false aneurysm just distal to ...
cardiovascular diseases
Mitral annular calcification: significant and worth acting upon. Mitral annular calcification (MAC) is a degenerative process which commonly occurs in the elderly and has multiple etiologies. Patients with MAC have a higher prevalence of left atrial enlargement, left ventricular enlargement, atrial fibrillation, conduc...
cardiovascular diseases
Physiologic and psychobehavioral research in oncology. A major thrust in research in psychosocial oncology is the study of the interaction of psychologic and physiologic variables. This discussion reviews the current status and future directions of such research. Areas addressed include pain, nausea and vomiting with c...
neoplasms
The importance of anatomic site in prognosis in patients with cutaneous melanoma. To determine the prognostic relevance of the anatomic site of origin of cutaneous melanoma to survival, we retrospectively analyzed a computerized database of 3428 patients with stage I and II cutaneous melanoma. Patients were stratified ...
neoplasms
The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography. We have studied regional cerebral blood flow changes in 6 patients after their recovery from a first hemiplegic stroke. All had a single well-defined hemispheric lesion and at least a brachial monoparesis that su...
general pathological conditions
DMPO and reperfusion injury: arrhythmia, heart function, electron spin resonance, and nuclear magnetic resonance studies in isolated working guinea pig hearts. With the use of isolated working guinea pig hearts with normothermic global ischemia, it was shown that 5,5-dimethyl-pirroline-N-oxide (DMPO), an organic spin t...
cardiovascular diseases
Temporal bone: three-dimensional CT. Part II. Pathologic alterations. Three-dimensional (3D) surface renderings were obtained from routine axial computed tomographic (CT) images in 15 patients with a variety of complex temporal bone abnormalities. The 3D CT reformations served as an adjunct to conventional sectional CT...
nervous system diseases
Left ventricular ejection fraction may not be useful as an end point of thrombolytic therapy comparative trials. In the era of comparative and adjunctive trials in reperfusion therapy, the need to develop alternative end points for mortality reduction is clear. Left ventricular ejection fraction, which has been commonl...
nervous system diseases
An electron and optical microscopic study of juxtaposed odontogenic keratocyst and carcinoma. Odontogenic keratocyst and squamous cell carcinoma commonly occur within the oral cavity; however, the juxtaposition of these lesions is rare. The light microscopic and ultrastructural features of such an event are reported. A...
neoplasms
Lexical organization of nouns and verbs in the brain. The analysis of neuropsychological disorders of lexical processing has provided important clues about the general organization of the lexical system and the internal structure of the processing components. Reports of patients with selective dysfunction of specific s...
nervous system diseases
Short-term radiotherapy as palliative treatment in patients with transitional cell bladder cancer. We report the results and complications of treatment with palliative, short-term radiotherapy in 162 elderly or disabled patients. Improvement in tumour-associated symptoms was noted in 75 of these patients and 72 survive...
neoplasms
A tongue force measurement system for the assessment of oral-phase swallowing disorders. A computer-aided measuring system using a highly sensitive beam transducer has been developed to provide a quantitative, reliable measure of tongue strength. This tool has application in both the diagnosis and treatment of dysphagi...
digestive system diseases
Laser photocoagulation control of diabetic macular oedema without fluorescein angiography. This study included 40 eyes in 22 diabetic patients with focal macular oedema. Laser photocoagulation was directed at decompensated or leaking microvascular lesions clinically detected without using pretreatment fluorescein angio...
general pathological conditions
Ki67 index and S-phase fraction in human breast carcinomas. Comparison and correlations with prognostic factors. In a prospective study of 148 consecutive breast adenocarcinomas, proliferative indices of the same surgical tumor sample were performed by immunohistologic staining (Ki67 index) with the use of the Ki67 mon...
general pathological conditions
Functional and metabolic effects of bupivacaine and lignocaine in the rat heart-lung preparation. We have examined the effects of bupivacaine and lignocaine on myocardial metabolism in the rat isolated heart-lung preparation. Bupivacaine 1, 5 or 25 micrograms ml-1 or lignocaine 4, 20 or 100 micrograms ml-1 was administ...
general pathological conditions
L-tryptophan associated eosinophilia-myalgia syndrome. Environmental chemicals are increasingly incriminated in the pathogenesis of several disease states. The eosinophilia-myalgia syndrome is a recently described entity attributed to the ingestion of the normal dietary amino acid L-tryptophan. We describe a patient wh...
nervous system diseases
Immunocytochemical characterization of lung tumors in fine-needle aspiration. The use of cytokeratin monoclonal antibodies for the differential diagnosis of squamous cell carcinoma and adenocarcinoma. In the current study, immunocytochemical typing of intermediate filaments was used for a differential diagnosis of huma...
neoplasms
Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis. Monoclonal antibody immunocytochemistry was used to examine spinal cord and muscle in amyotrophic lateral sclerosis for changes that would indicate ongoing or potential immune activity. Increased expression of ...
general pathological conditions
Sudden death and sleeping history among Finnish men. An autopsy was performed in 460 consecutive cases of sudden death among 35- to 76-year-old men. The closest cohabiting individual known to each decreased subject was interviewed. Snoring history was obtained in 321 of the 371 interviews. In 86 cases there was a histo...
general pathological conditions
Xipamide disposition in liver cirrhosis. The pharmacokinetics of the sulfonamide-type diuretic xipamide was studied in patients with liver cirrhosis and ascites and compared with healthy control subjects. After oral administration of 40 mg xipamide, the diuretic was rapidly distributed in the blood and the ascites. The...
digestive system diseases
Cutaneous malignant melanoma in Rochester, Minnesota: trends in incidence and survivorship, 1950 through 1985 In Rochester, Minnesota, 107 incidence cases of cutaneous malignant melanoma (in 46 male and 61 female patients) were diagnosed during the years 1950 through 1985. Overall crude incidence rates were 6.0 and 6.6...
neoplasms
Diagnosis of obstructive sleep apnea. The diagnosis of obstructive sleep apnea is frequently made by taking a meticulous history coupled with a high index of suspicion. Snoring and hypersomnolence are clinical features common to individuals with sleep apnea. Since snoring is said to be a "disease of listeners," it is n...
nervous system diseases
Clinical and anatomic considerations for surgery in tibial disease and the results of surgery. Bypass vein grafts to the infrapopliteal arteries now achieve a 5-year cumulative patency equivalent to that of vein grafts to the popliteal arteries. The technique of in situ vein grafting to the tibial arteries is described...
cardiovascular diseases
The role of mucous glycoproteins in the rheologic properties of cystic fibrosis sputum. Cystic fibrosis (CF) is characterized by excessive amounts of thick and tenacious mucous secretions that obstruct organ ducts and passages. In the respiratory tract this is associated with chronic infection resulting in the hypersec...
general pathological conditions
Effect of intraesophageal location and muscarinic blockade on balloon distension-induced chest pain. Intraesophageal balloon distension has been introduced recently as a provocative test in the assessment of patients with noncardiac chest pain. In order to examine the effect of balloon location and muscarinic blockade ...
digestive system diseases
Gastroduodenal mucosa in uraemia: endoscopic and histological correlation and prevalence of helicobacter-like organisms. This study aimed to determine the prevalence of endoscopic and histological gastroduodenitis as well as helicobacter-like organisms in patients with end stage renal failure undergoing maintenance dia...
general pathological conditions
Snoring and sleep architecture. The purpose of this study was to examine whether snoring adversely affects sleep architecture and sleep efficiency, and thus may account for the frequent complaints of daytime tiredness and fatigue expressed by heavy snorers. We recruited eight self-confessed heavy snorers and six self-c...
general pathological conditions
Tumors of the central nervous system. Improvement in outcome through a multimodality approach. More children with CNS tumors will continue to be cured of their neoplasms as a result of improved surgical, radiotherapeutic, and chemotherapeutic intervention. The complex problems seen in these patients mandate their treat...
neoplasms
Approaches to the patient with aspiration and swallowing disabilities. Aspiration, or soiling of the tracheobronchial tree, can produce life-threatening pulmonary disease. Intermittent or persistent aspiration may cause symptoms including cough, intermittent fever, recurrent tracheobronchitis, atelectasis, pneumonia, a...
digestive system diseases
Proliferative mass found in the gingiva. The clinical course of peripheral ossifying fibroma is slow and the growth of most lesions is limited in size, usually up to 1.5 cm. Complaints are rare unless the surface becomes ulcerated, or the lesion compromises oral function or esthetic appearance. Treatment is surgical ex...
neoplasms
Intraperitoneal cisplatin and cytarabine in the treatment of refractory or recurrent ovarian carcinoma Preclinical evaluation has suggested impressive concentration-dependent cytotoxic synergy between cisplatin and cytarabine in ovarian carcinoma. To further evaluate the clinical relevance of these observations, 39 pat...
neoplasms
Initial CT findings in 753 patients with severe head injury. A report from the NIH Traumatic Coma Data Bank. In this prospective multicenter study, the authors have examined data derived from the initial computerized tomography (CT) scans of 753 patients with severe head injury. When the CT findings were related to abn...
nervous system diseases
Possible platelet contribution to pathogenesis of transient neonatal hyperammonaemia syndrome. The pathogenesis of the transient neonatal hyperammonaemia syndrome is largely unknown. The role of platelet activation was investigated in three preterm infants with this syndrome by non-invasive methods. In all three infant...
general pathological conditions
Local infectious complications following large joint replacement in rheumatoid arthritis patients treated with methotrexate versus those not treated with methotrexate. We performed a 10-year retrospective analysis of the frequency of local postoperative infectious complications in methotrexate (MTX)-treated rheumatoid ...
general pathological conditions
Follow-up of patients who underwent arterial switch repair for transposition of the great arteries Thirty infants underwent arterial switch for transposition of the great arteries within the first week of life (mean age, 2.8 days). An additional three patients underwent repair at 5 1/2, 8, and 9 1/2 months of age. Six ...
cardiovascular diseases
Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance. Transforming growth factor-beta 1 (TGF-beta 1) is thought to play a role in modulating vascular cell function in vivo. In vitro, it decreases endothelial cell proliferation and migration. We postulated that these bio...
neoplasms
Doppler assessment of pulmonary hypertension induced by hypoxic breathing in subjects susceptible to high altitude pulmonary edema. To verify the abnormal pulmonary vascular response implicated in the pathogenesis of high altitude pulmonary edema (HAPE), we examined the hemodynamic responses to hypoxia in HAPE-suscepti...
cardiovascular diseases
Colon cancer in pregnancy with elevated maternal serum alpha-fetoprotein level at presentation. A case of colon cancer in pregnancy is presented in which the maternal serum alpha-fetoprotein level was elevated. Failure to evaluate colon cancer as a cause of the elevated maternal serum alpha-fetoprotein may have account...
neoplasms
Itraconazole therapy for nonmeningeal coccidioidomycosis: clinical and laboratory observations. Itraconazole, a new oral triazole antifungal agent, was administered in 75 courses to patients with chronic coccidioidomycosis at dosages of 50 to 400 mg/day for a median duration of 10 months. Assessment of efficacy was mad...
general pathological conditions
The role of etoposide in the treatment of poorly differentiated carcinoma of unknown primary site. Patients with poorly differentiated carcinoma (PDC) or poorly differentiated adenocarcinoma (PDA) of unknown primary site comprise 25% to 35% of the patients with carcinoma of unknown primary site. Some of these patients ...
neoplasms
Traumatic and spontaneous extracranial internal carotid artery dissections. Seventy patients with spontaneous and 21 with traumatic extracranial internal carotid artery dissections were studied clinically and angiographically with mean follow-ups of 64 (spontaneous group) and 40 months (traumatic group). Sixty percent ...
cardiovascular diseases
Effect of cyclosporine on the development of cerebral vasospasm in a primate model. The authors studied the effect of the immunosuppressive drug cyclosporine (CS) on the development of cerebral vasospasm after subarachnoid hemorrhage (SAH) using a primate model of vasospasm. Eighteen monkeys were randomly divided into ...
cardiovascular diseases
Symptomatic pericardial effusion in lung cancer patients: the role of fluid cytology. During the years 1975-1988, twenty lung cancer patients with symptomatic pericardial effusion were treated conservatively at our center. Echocardiography demonstrated small pericardial effusion in 2 patients, medium size effusion in 3...
cardiovascular diseases
An unusual manifestation of Paget's disease of bone: spinal epidural hematoma presenting as acute cauda equina syndrome. Neurologic sequelae of Paget's disease of bone include involvement of the spinal cord or cauda equina due to mechanical compression by enlarged vertebrae, ischemia caused by a spinal artery, steal sy...
nervous system diseases
Chronic pain in primary care. Identification and management of psychosocial factors. Chronic pain is a problem of great public health importance that is frequently seen in the primary care setting. Pain chronicity shows a strong association with psychosocial factors. Assessment of these factors should be composed of tw...
general pathological conditions
Hormonal dependency of cerebral meningiomas. Part 1: Female sex steroid receptors and their significance as specific markers for adjuvant medical therapy. Female sex steroid receptors were examined in 50 human cerebral meningiomas. For estrogen receptors, high-affinity binding sites (dissociation constant (Kd): 0.05 to...
neoplasms
Activation and inducer subset phenotype of the lymphocytic infiltrate around epidermally derived tumors. An in situ analysis of the mononuclear cell infiltrate found in association with a range of benign, premalignant, and malignant epidermal tumors is described. The predominant cell phenotype was that of the recently ...
neoplasms
Glutathione S-transferase. Novel vaccine against Fasciola hepatica infection in sheep. The potential of GST as a vaccine candidate against liver fluke infection in ruminants was studied by vaccinating sheep (n = 9) with GST purified from adult worms of Fasciola hepatica and challenging with 500 F. hepatica metacercaria...
digestive system diseases
Untying the gordian knot: the genetics of Tourette syndrome. A review of the current status of the genetics of Tourette syndrome is presented. Over the course of the 104 years since Gilles de la Tourette described the syndrome that bears his name, a body of carefully collected, described, and analyzed data has produced...
nervous system diseases
Hemiparetic multiple sclerosis. Eight patients are described who presented with hemiparesis which involved the face in seven. Six of the eight subsequently developed clinically definite multiple sclerosis and in the remaining two patients multiple sclerosis was the likely diagnosis. Magnetic resonance imaging gave usef...
general pathological conditions
7th nerve palsy after extradural blood patch. We describe a patient who developed a 7th cranial nerve palsy following an extradural blood patch; full recovery followed. The likely aetiology is discussed.
nervous system diseases
Timing of operation for aortic regurgitation: relation to postoperative contractile state. With angiography and pressure measurement, we determined left ventricular volume, wall stress, and systolic performance in 30 patients with aortic regurgitation before and after successful aortic valve replacement. End-systolic w...
general pathological conditions
Dementia: what to do. Dementia is a syndrome of acquired intellectual deterioration that interferes with personal or social functioning. Diagnosis requires historical information from the family and the mental status evaluation of orientation, recent memory, comprehension, calculation, and abstraction. Most dementias c...
nervous system diseases
Stroke recurrence within 2 years after ischemic infarction. We prospectively studied stroke recurrence in 1,273 patients with ischemic stroke who were entered into the Stroke Data Bank. Median follow-up was 13 months. The 2-year cumulative recurrence rate among these patients was 14.1%. Age, sex, race, history of hyper...
general pathological conditions
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity. Several proteins implicated in the regulation of cell proliferation contain a common noncatalytic domain, src homology region 2 (SH2). We have used the bacterially expressed SH2 d...
general pathological conditions
Disseminated strongyloidiasis with central nervous system involvement diagnosed antemortem in a patient with acquired immunodeficiency syndrome and Burkitts lymphoma. A 45-year-old man presented with central nervous system involvement as the initial manifestation of disseminated infection with Strongyloides stercoralis...
neoplasms
Intracranial tumor in infants: characteristics, management, and outcome of a contemporary series. Since 1980, 22 patients less than 2 years of age have been treated for intracranial tumors at our institution. The most common presentation was elevated intracranial pressure associated with ventriculomegaly (73%). The dia...
neoplasms
Central visual field changes after panretinal photocoagulation in proliferative diabetic retinopathy. This study comprises 53 eyes, divided into two groups A and B, with proliferative diabetic retinopathy which were treated with panretinal photocoagulation (PRP). Its purpose is to investigate the alterations in the cen...
general pathological conditions
The scapegoat effect on food aversions after chemotherapy. The effects of consuming a novel food (halva) versus a familiar food (cookies) before gastrointestinal (GI) toxic chemotherapy on patients' preference for familiar foods consumed after chemotherapy treatment were compared. The development of aversions to the no...
general pathological conditions
Philadelphia chromosome and monosomy 7 in childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study. During an 8-year period, 3,638 children from institutions of the Pediatric Oncology Group (POG) were diagnosed with acute lymphoblastic leukemia (ALL). Fifty-seven patients had Philadelphia chromosome-pos...
general pathological conditions
The influence of dialysate sodium and variable ultrafiltration on fluid balance during hemodialysis. An important factor in the development of hypotension during hemodialysis (HD) is a decrease in blood volume, due to ultrafiltration (UF) and an insufficient refill of the intravascular compartment. This insufficient re...
nervous system diseases
Development of multiple necrotizing enteritis induced by a tumor necrosis factor-like cytokine from lipopolysaccharide-stimulated peritoneal macrophages in rats. We report the development of an animal model of multiple necrotizing enteritis (MNE) in rats. When rats were injected directly with a culture supernatant of l...
general pathological conditions
Technetium-99m-HMPAO brain SPECT in medically intractable temporal lobe epilepsy: a postoperative evaluation. The aim of the present study was to evaluate the predictive value of interictal single-photon emission computed tomography (SPECT) using technetium-99m-labeled hexamethyl propyleneamine oxime (HMPAO) for the ou...
neoplasms
Significance and treatment of positive margins or seminal vesicle invasion after radical prostatectomy. The periprostatic soft-tissue involvement described in the older urologic literature differs from that now recognized; a much "earlier" pathologic stage C is being identified. Apparent microscopic extension of the ca...
neoplasms
P300 brain activity in seizure patients preceding temporal lobectomy. Event-related potentials were recorded over occipital and parietal scalp from 20 patients suffering from intractable partial complex seizures prior to undergoing a temporal lobectomy. Subjects were presented with language and nonlanguage visual stimu...
nervous system diseases
The use of obstetric analgesia in Sweden 1983-1986 The use of obstetric analgesia was investigated in a Swedish population-based prospective study of 335,207 births, which represents almost all women who had vaginal deliveries in Sweden between 1983 and 1986. Lumbar epidural analgesia (EDA) was used in 16%, paracervica...
nervous system diseases
A composite driving system for LVAS and IABP: practical and effective driving and weaning. We have devised a new method, termed alternate synchronous driving (ASD), to wean patients from a left ventricular assist system (LVAS) to a pressure assist intraaortic balloon pump (IABP). We have built a new drive unit, VCT200,...
cardiovascular diseases
Six year follow up of a consecutive series of patients presenting to the coronary care unit with acute chest pain: prognostic importance of the electrocardiogram In a retrospective 6 year follow up data were obtained for 536 of 566 (95%) consecutive patients admitted to a coronary care unit with acute chest pain. Their...
cardiovascular diseases
Changes in gastric mucosa that antedate gastric carcinoma. Endoscopic biopsy specimens of the gastric mucosa from 13 patients who were found at follow-up examination to have gastric carcinoma were compared for abnormal histologic features, type of intestinal metaplasia, and presence of immunoreactive carcinoembryonic a...
neoplasms
Fetal alcohol syndrome in adolescents and adults. Fetal alcohol syndrome is a specific recognizable pattern of malformation. Manifestations in 61 adolescents and adults suffering from alcohol teratogenesis are presented. After puberty, the faces of patients with fetal alcohol syndrome or fetal alcohol effects were not ...
nervous system diseases
Primary orchiectomy versus estrogen therapy in advanced prostatic cancer--a randomized study: results after 7 to 10 years of followup. Of 163 new consecutively diagnosed cases of advanced (T3-4 M0 or T04M1) prostatic cancer 13 had contraindications for estrogen treatment, and the remainder were randomized to orchiectom...
cardiovascular diseases
The current spectrum of peptic ulcer disease in the older age groups. Not only has there been a relative increase in the prevalence of peptic ulcer disease (PUD) among America's older age groups, but the characteristics of PUD in these patients differ significantly from those of the general population. Seventy-two cons...
digestive system diseases
Immune complexes in the choroid plexus in liver cirrhosis. A histopathologic and immunofluorescence study of the choroid plexus was performed in 12 cases of liver cirrhosis (cirrhosis group) and in 20 patients who died of diseases with no evidence of liver or brain involvement, and in which renal disease and alcoholism...
digestive system diseases
Headache: a marker of depression Patients who presented with a chief complaint of headache in the outpatient family practice setting were found to have a high prevalence of depression (63%) by the Zung Self-Rating Depression Scale (SDS) index. A statistically significant relationship was found between the frequency of ...
nervous system diseases
Can nurses perform surgical cricothyrotomy with acceptable success and complication rates? STUDY OBJECTIVE: This study was undertaken to determine whether flight nurses can perform surgical cricothyrotomies with acceptable success and complication rates. METHODS: This case series examined the survival, success, and com...
general pathological conditions
Seronegative juvenile rheumatoid arthritis and mast cell-associated gastritis. We describe 4 children with seronegative inflammatory arthritis who had persistent, severe nausea and abdominal pain over several months, in spite of vigorous medical therapy, including antacids and histamine H2 receptor antagonists. Endosco...
digestive system diseases
Treatment of osteonecrosis of the femoral head by drilling and muscle-pedicle bone grafting. Sixty-one patients with 68 osteonecrotic femoral heads, at different stages of development, were treated surgically; their average age was 36 years. Necrosis followed a fracture in 43 hips and traumatic dislocation in three. It...
general pathological conditions
Elevated expression of the c-fes proto-oncogene in adult human myeloid leukemia cells in the absence of gene amplification. Expression of the 93-kd tyrosine kinase encoded by the human c-fes proto-oncogene (also known as FES) is restricted to mature hematopoietic cells of the granulocytic and monocytic lineages, sugges...
neoplasms
Surgical correction of recurrent venous ulcer. Seventy-six limbs from 46 patients with comparable superficial and deep venous valve incompetence underwent surgical correction for recurrent venous ulcers of the leg that were refractory to various modes of nonsurgical and surgical treatments. A follow-up of 10 to 73 mont...
cardiovascular diseases
Perioperative methotrexate, vinblastine, doxorubicin and cisplatin (M-VAC) for poor risk transitional cell carcinoma of the bladder: an Eastern Cooperative Oncology Group pilot study. A total of 18 patients with locally advanced transitional cell carcinoma of the bladder underwent 2 preoperative cycles of chemotherapy ...
cardiovascular diseases
The surgical pathologist's role in liver transplantation. Liver transplantation has become an option in treating a wide variety of diseases. The surgical pathologist, as a member of the transplantation team, is increasingly involved in the evaluation of allograft dysfunction. Interpretation of the liver allograft biops...
cardiovascular diseases