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Perforation and tumor formation of the intestine in primary amyloidosis. We report a case of primary amyloidosis with repeated bowel perforations. This patient also had localized amyloid deposition creating a tumorous region mimicking malignancy in the rectum. Perforation of the intestine is common in systemic amyloido... | neoplasms |
Evaluation of minor head trauma in children younger than two years. The recent medical literature emphasizes the limitations of skull films in the evaluation of minor head trauma. However, the emergency medicine literature places little emphasis on the particular risks in children younger than 2 years old with blunt he... | nervous system diseases |
In vitro evaluation of bleomycin-induced cell lethality from plastic and glass containers. To optimize cancer chemotherapy, a considerable amount of research has been expended to study pharmacologic, pharmacokinetic, biochemical, and pharmaceutic properties of antineoplastic agents. However, published data on the stabi... | neoplasms |
Magnetic resonance in pediatric and adolescent neuroimaging. With improved availability and a practical understanding of the principles of utilization, MRI will continue to replace CT and US in pediatric neuroimaging, just as it has impacted upon the more invasive modalities. In general, US remains the procedure of cho... | nervous system diseases |
Acute central nervous system symptoms caused by ibuprofen in connective tissue disease. We describe 2 cases of acute encephalopathy in patients with connective tissue disease caused by small doses of ibuprofen. In addition to aseptic meningitis, both patients had altered mental status and focal neurologic signs, ophtha... | cardiovascular diseases |
A controlled clinical trial to assess the effect of a calcium channel blocker on the progression of coronary atherosclerosis To determine whether calcium channel blockers influence the progression of coronary atherosclerosis, 383 patients age 65 years or less with 5-75% stenoses in at least four coronary artery segment... | general pathological conditions |
Multiplexing studies of effects of rapid atrial pacing on the area of slow conduction during atrial flutter in canine pericarditis model. BACKGROUND. We report that rapid atrial pacing interrupts atrial flutter when the orthodromic wave front from the pacing impulse is blocked in an area of slow conduction in the reent... | cardiovascular diseases |
Transesophageal Doppler color flow mapping assessment of atrial septal defect. Transesophageal Doppler color flow imaging was performed in 19 adult patients (mean age 35 years) with an atrial septal defect demonstrated by cardiac catheterization or at surgery, or both. The transesophageal study correctly identified and... | cardiovascular diseases |
Hypertrophic cardiomyopathy without hypertrophy: two families with myocardial disarray in the absence of increased myocardial mass Two families are described in which individuals showed widespread myocardial disarray at histological examination, in the absence of macroscopic cardiac hypertrophy. In one family the clini... | general pathological conditions |
A critical appraisal of mitogen-induced lymphocyte proliferation in depressed patients. OBJECTIVE: The authors' goal was to evaluate the utility of mitogen-induced lymphocyte proliferation assays in clinical research in psychoimmunology. METHOD: They examined 23 depressed patients and 23 matched comparison subjects wit... | nervous system diseases |
Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. The diversity of infectious agents capable of inducing meningitis and blood-brain barrier (BBB) injury suggests the potential for a common host mediator. The inflamma... | nervous system diseases |
Hemodynamic effects of partial correction of chronic anemia by recombinant human erythropoietin in patients on dialysis. Eighteen patients on chronic hemodialysis with renal anemia were treated with recombinant human erythropoietin (r-HuEPO). Hemodynamic parameters in the resting state were determined before and after ... | cardiovascular diseases |
Mini-Mental State exam scores vary with education in blacks and whites. Previous studies have suggested that education and race may affect performance on standardized mental status tests. In order to more clearly define these relationships, a prospective longitudinal study was devised to answer two questions: (1) wheth... | nervous system diseases |
Permanent external striated sphincter stents in patients with spinal injuries. Nine patients with complete quadriplegia underwent external striated sphincter stenting with the Wallstent in place of an external striated sphincterotomy. Although suprapubic catheters were placed to provide an outlet should problems develo... | general pathological conditions |
Investigation of mode of action of biofeedback in treatment of fecal incontinence. A study was carried out in 25 incontinent patients to evaluate some of the factors thought to be responsible for the success of retraining for fecal incontinence. Subjects were initially allocated to one of two groups; one group was trai... | digestive system diseases |
Periurethral colonic-type polyp simulating urethral caruncle. A case report. A 50-year-old, black woman presented with a 1-cm, polypoid lesion on the posterior edge of the urethral meatus that had the gross appearance of a urethral caruncle. The histologic features, however, revealed a superficially ulcerated lesion co... | neoplasms |
Middle cerebral artery strokes causing homonymous hemianopia: positron emission tomography. Eight patients were evaluated with 18F-fluorodeoxyglucose positron emission tomography between 3 and 30 days after isolated stroke involving the middle cerebral artery territory that caused homonymous hemianopia. Diffuse hypomet... | nervous system diseases |
Subacute necrotizing sialadenitis. Twelve cases of a heretofore unreported minor salivary gland disease have been reported. Although an infectious cause is suspected for this self-limiting inflammatory process, the actual cause remains unknown. It typically presents as a unilateral, erythematous, nonuclerated but painf... | general pathological conditions |
A prospective study of patients with sciatica. A comparison between conservatively treated patients and patients who have undergone operation, Part I: Patient characteristics and differences between groups. Based on a prospective study on 342 sciatica patients examined with rhizography, the aim was to determine which f... | general pathological conditions |
Comparison of 1073 MBq and 3700 MBq iodine-131 in postoperative ablation of residual thyroid tissue in patients with differentiated thyroid cancer. In a randomized prospective study, we compared the efficacy of low dose (1073 MBq) and high dose (3700 MBq) iodine-131 administration in postoperative ablation of residual ... | neoplasms |
Colon interposition for esophageal disease: histologic finding of colonic mucosa after a follow-up of 5 months to 15 years. Thirty-six patients, subjected to colon interposition for benign esophageal disease or carcinoma of the esophagus or gastric cardia, were studied by endoscopy for signs of mucosal disease in the i... | digestive system diseases |
Mechanical circulatory support as a bridge to transplantation: current status of total artificial heart in 1989 and determinants of survival. Since April 1986, 40 total artificial hearts (TAH) were implanted as a bridge to transplantation in our institution. In an attempt to identify factors affecting survival of TAH r... | cardiovascular diseases |
Dysmorphogenesis elicited by microinjected acetaminophen analogs and metabolites in rat embryos cultured in vitro. Direct additions of acetaminophen (APAP), 3,5-dimethylacetaminophen, 3-hydroxyacetaminophen or 3-methoxyacetaminophen to the medium of cultured embryos each produced an increased incidence of morphological... | nervous system diseases |
Gastric outlet obstruction caused by traumatic pseudoaneurysm of superior mesenteric artery. Traumatic pseudoaneurysms of the superior mesenteric artery (SMA) are extremely rare. We describe two cases of posttraumatic proximal SMA pseudoaneurysms with symptoms of gastric outlet obstruction. Repair was accomplished by a... | digestive system diseases |
Serous papillary adenocarcinoma of the tunica vaginalis of the testis with metastasis. Testicular or paratesticular neoplasms that resemble the common epithelial type of ovarian tumor are quite rare. The authors report the case of a 29-year-old man with a metastatic serous papillary adenocarcinoma arising from the tuni... | neoplasms |
Preseason strength and flexibility imbalances associated with athletic injuries in female collegiate athletes. One hundred thirty-eight female collegiate athletes, participating in eight weightbearing varsity sports, were administered preseason strength and flexibility tests and followed for injuries during their sport... | general pathological conditions |
Hypertension prevalence and the status of awareness, treatment, and control in the Hispanic Health and Nutrition Examination Survey (HHANES), 1982-84 The prevalence rates of hypertension among adult (ages 18-74) Mexican Americans, Cuban Americans, and Puerto Ricans were estimated using data from the 1982-84 Hispanic He... | cardiovascular diseases |
Lateral medullary infarction: prognosis in an unselected series. We describe the acute and long-term prognosis in 43 patients with lateral medullary infarction (LMI) collected from a population-based stroke registry from 1982 to July 1988. Mean age was 63.9 years and median time of follow-up was 33 months. In the acute... | cardiovascular diseases |
A vascular malformation mimicking an intracanalicular acoustic neurilemoma. Case report. A patient with an enhancing, completely intracanalicular mass on magnetic resonance imaging was operated on for a presumed acoustic neurilemoma, but was found at surgery to have an intracanalicular vascular malformation. This rare ... | neoplasms |
Results of percutaneous transluminal coronary angioplasty of high-risk angulated stenoses. Percutaneous transluminal coronary angioplasty (PTCA) of angulated stenoses has been found in studies using older PTCA equipment to be associated with a heightened risk of procedure-related major ischemic events. To better unders... | general pathological conditions |
Missed injuries. The trauma surgeon's nemesis. The multiply injured trauma patient presents a diagnostic and therapeutic challenge: that of discovering all injuries while simultaneously proceeding with resuscitation and maintaining life. Many factors involved in the initial resuscitation of the multiply injured patient... | nervous system diseases |
Tension pneumocephalus: treatment with controlled decompression via a closed water-seal drainage system. Case report. The successful treatment of a patient with tension pneumocephalus by controlled decompression via external drainage is described. The advantage of the technique includes the immediate release of high pr... | nervous system diseases |
Does age affect outcomes of out-of-hospital cardiopulmonary resuscitation? We examined the relation between age and outcomes in patients treated for out-of-hospital cardiac arrest in Seattle, Wash. Considering all out-of-hospital cardiac arrests treated by paramedics over a recent 5-year period, 386 (27%) of 1405 conse... | general pathological conditions |
Pathological observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers. III. Survey of necroinflammation and cystic dilatation. Pathological changes and significance of intrahepatic peribiliary glands, hitherto poorly recognized intrahepatic elements, have been evaluated in our laboratory. In ... | neoplasms |
Is adenosine 5'-triphosphate derangement or free-radical-mediated injury the major cause of ventricular dysfunction during reperfusion? Role of adenine nucleoside transport in myocardial reperfusion injury. The aim of this study was to determine the dual role of ATP as an energy substrate and as a major source of oxyge... | cardiovascular diseases |
Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Three patients with hematologic relapse after bone marrow transplantation for chronic myelogenous leukemia were treated with interferon alpha and transfusion of viable donor buffy coat. All had complete h... | general pathological conditions |
Mechanisms of gallstone formation in women. Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism. Our aim was to define mechanisms whereby conjugated estrogens (Premarin, exogenous estrogen; Ayerst Laboratories, New York) increase the risk of developing cholesterol gallstones and... | digestive system diseases |
Rural-urban differences in stage at diagnosis. Possible relationship to cancer screening. Stage at diagnosis was examined for various malignancies identifiable through screening to determine whether rural-urban differences exist in Georgia. Data were obtained from a population-based cancer registry which registers all ... | neoplasms |
Effects of aging on the swallowing mechanism. Normal swallow involves a number of closely coordinated neuromuscular events. Investigators have identified some small temporal changes in the swallow of older adults as compared with young adults. Further research is needed to define completely the primary effects of aging... | digestive system diseases |
Seizure disorders in Down syndrome. The prevalence, onset, and type of seizure disorders, as well as seizure control, were studied in a large cohort of 405 individuals with Down syndrome (age range, 6 months to 45 years). The evaluation of a questionnaire completed by the subjects' parents and of the patients' medical ... | nervous system diseases |
Healing of a large nonossifying fibroma after grafting with bone matrix and marrow. A case report. Healing of a large tibial nonossifying fibroma in a 12-year-old girl occurred following excision, curettage, and filling of the bony defect with human demineralized bone matrix powder mixed with a small quantity of the pa... | neoplasms |
Extrageniculate vision in hemianopic humans: saccade inhibition by signals in the blind field. The functional competence of extrageniculate visual pathways in hemianopic humans was demonstrated by showing that distractor signals in the blind half of the visual field could inhibit saccades toward targets in the intact v... | nervous system diseases |
Platelet-activating factor. A putative mediator in central nervous system injury? Platelet-activating factor (1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a potent lipid autacoid produced by many cell types. Platelet-activating factor is produced by cerebellar granule cells in culture and has been extracte... | nervous system diseases |
Proximal esophageal pH-metry in patients with 'reflux laryngitis'. Fiberoptic laryngoscopic examinations were performed on 40 patients with gastroesophageal reflux disease, 25 of whom had persistent laryngeal symptoms (dysphonia, cough, globus sensation, frequent throat clearing, or sore throat) and 15 without laryngea... | digestive system diseases |
Intraoperative pleural lavage cytology in lung cancer patients. Cytology of intraoperative pleural lavage was examined in 164 lung cancer patients who underwent pulmonary resections. None of the patients had any pleural effusion or dissemination. Cytology was performed three times: (1) at thoracotomy, (2) immediately a... | neoplasms |
Anton's syndrome in a patient with posttraumatic optic neuropathy and bifrontal contusions. We describe a patient who manifested Anton's syndrome after sustaining head trauma that resulted in optic nerve damage and bifrontal contusions. Denial of monocular blindness, generalized anosognosia, and confabulation were prom... | general pathological conditions |
Warm induction blood cardioplegia in the infant. A technique to avoid rapid cooling myocardial contracture. The use of profound hypothermia and total circulatory arrest for repair of heart defects in neonates usually involves a period of systemic and myocardial bypass cooling. Rapid cooling of muscle (skeletal, smooth,... | cardiovascular diseases |
New approaches in the rehabilitation of the traumatic high level quadriplegic. The use of noninvasive alternatives to tracheostomy for ventilatory support have been described in the patient management of various neuromuscular disorders. The use of these techniques for patients with traumatic high level quadriplegia, ho... | nervous system diseases |
Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study. This randomized, double-blind, multi-centre study was undertaken to evaluate the efficacy and safety of treatment for 4 weeks with codeine plus paracetam... | nervous system diseases |
Generation of ammonia and mucosal lesion formation following hydrolysis of urea by urease in the rat stomach. We examined the morphological changes in gastric mucosa and the generation of ammonia after exposure of the rat stomach to urea in the presence of urease, in attempts to investigate a pathophysiological role of... | digestive system diseases |
Recurrent renal cell carcinoma arising in Wilms' tumor. A 19-month-old black girl had a radical nephrectomy for a Wilms' tumor that contained areas of epithelium indistinguishable from renal cell carcinoma. She was treated with chemotherapy but subsequently had pulmonary metastases develop and massive abdominal recurre... | general pathological conditions |
Effects of common illnesses on infants' energy intakes from breast milk and other foods during longitudinal community-based studies in Huascar (Lima), Peru. To assess the effects of common infections on dietary intake, 131 Peruvian infants were observed longitudinally. Home surveillance for illness symptoms was complet... | digestive system diseases |
Subnormal parasympathetic activity after cardiac transplantation. Heart period variability (standard deviation of 120 consecutive RR or PP intervals) was used to assess baseline parasympathetic activity in 18 patients with congestive heart failure before and after orthotopic cardiac transplantation, and was compared to... | cardiovascular diseases |
An unusual complication of silastic dural substitute: case report. A case is presented in which a patient developed an unusual complication after the use of Silastic dural substitute. In 1983, the patient underwent removal of a meningioma with the involved dura. Five years later, he developed around the graft material ... | nervous system diseases |
99TCm-HMPAO SPECT studies in traumatic intracerebral haematoma. Traumatic intracerebral haematomas are a common neurosurgical emergency. Their management, particularly the role of surgical removal, is controversial. Deterioration often occurs late, and is unpredictable. Eight patients with traumatic intracerebral haema... | general pathological conditions |
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. PC2 and furin are two recently identified members of a class of mammalian proteins homologous to the yeast precursor processing protease kex2 and the bacterial subtillisins. We have used the... | neoplasms |
Bleeding ectatic vascular lesion involving the sigmoid colon, endoscopically indistinguishable from angiodysplasia, in an 8-yr-old boy. An 8-yr-old Japanese boy was hospitalized, complaining of active hematochezia. He was shown to have a cherry-red, blood-oozing area of vascular dilation with mucosal prominence in the ... | general pathological conditions |
Effects of standing on the induction of paroxysmal supraventricular tachycardia. To evaluate the effects of standing on induction of paroxysmal supraventricular tachycardia, electrophysiologic studies were performed in both the supine and standing positions in 22 patients with atrioventricular (AV) reciprocating tachyc... | cardiovascular diseases |
Molecular surgery of the basement membrane by the argon laser. Although the argon laser is used successfully to weld a number of different tissues, the underlying chemical and cellular mechanisms for this process are not precisely defined. Consequently, a biochemical model has been developed in vitro using the well-def... | neoplasms |
Percutaneous transhepatic cholecystostomy for acute complicated cholecystitis in elderly patients. We report our experience with percutaneous transhepatic cholecystostomy in 10 elderly patients with acute cholecystitis, complicated by empyema formation. Most of these patients has severe underlying disease, rendering th... | digestive system diseases |
Valvular and coronary surgery in renal transplant patients. The Authors report aortic valvular replacement (AVR) and coronary artery bypass graft surgery (CABG) successfully performed in two renal transplant patients. The postoperative blood urea and creatinine levels were comparable to the preoperative values. The fir... | cardiovascular diseases |
A multifocal schwannoma of the masseteric nerve causing hemicrania. A case is reported of schwannoma of the right masseteric nerve, invading the pterygopalatine fossa and the parapharyngeal space through the mandibular notch in a 61-year-old woman. The tumor in this case was composed of four various-sized interconnecte... | nervous system diseases |
The epilepsies: clinical implications of the international classification. From the earliest days of neurology, the classification of epileptic seizures into those generalized from the beginning and those with a definable localization in the cortex from the onset has added to knowledge about the function of the nervous... | nervous system diseases |
Intradural herniation of a thoracic disc presenting as flaccid paraplegia: case report. A case of intradural herniation of a thoracic disc in a patient with a flaccid paraplegia is described. Intradural herniation of a thoracic disc is considered a rare event. A review of the relevant patient literature revealed 14 oth... | general pathological conditions |
Refractory parastomal ulcers: a multidisciplinary approach. Chronic parastomal ulcers in patients with ileostomy or colostomy stomas are unusual. Previous reports have implicated infections, fistulas, recurrent inflammatory bowel disease (IBD), pyoderma gangrenosum, and trauma. Over the past 8 years we have evaluated 1... | neoplasms |
The effect of long-acting somatostatin analogue on enzyme changes after endoscopic pancreatography. The effect of the long-acting somatostatin analogue, octreotide acetate (Sandostatin) on enzyme elevation after endoscopic pancreatography was studied in a prospective, randomized, double-blind trial. Sixty-three consecu... | digestive system diseases |
Stress-related mucosal damage: review of drug therapy. The increased awareness of stress-related mucosal damage (SRMD) that accompanied the widespread use of fiberoptic endoscopy and the increased incidence of SRMD that accompanied the advances in caring for critically ill patients resulted in the recognition that the ... | digestive system diseases |
The occurrence of motor fluctuations in parkinsonian patients treated long term with levodopa: role of early treatment and disease progression. The aim of this study is to evaluate what factors influence the risk of occurrence of motor fluctuations in patients with Parkinson's disease (PD) with particular reference to ... | nervous system diseases |
The importance of intraoperative cholangiography during laparoscopic cholecystectomy. Laparoscopic cholecystectomy (LC) using electrocoagulation was successfully performed in 56 out of 58 selected patients. Cholangiography was performed in 53 patients. Six patients had common duct stones; five were unsuspected preopera... | digestive system diseases |
Hormone replacement therapy. How to select the best preparation and regimen. Hormone replacement therapy is a mainstay of preventive healthcare for the maturing female population. Estrogen deficiency that comes with menopause can have serious effects and is especially important in light of the increasing life expectanc... | cardiovascular diseases |
Cecal diverticulitis presented as a cecal tumor. Seven patients diagnosed as having acute appendicitis were operated on and a cecal wall mass due to cecal diverticulitis was found. In two patients the mass could not be separated from the cecal wall and right colectomy was performed. In five patients, in whom the mass c... | general pathological conditions |
Push-enteroscopy for diagnosis of patients with gastrointestinal bleeding of obscure origin. Push-enteroscopy using a disinfected colonoscope was performed on 39 patients with gastrointestinal bleeding of obscure origin. Our results show that: (1) A high percentage of patients (38%) have pathological lesions responsibl... | general pathological conditions |
Unsuspected mitral stenosis. PURPOSE AND PATIENTS AND METHODS: We observed a series of patients in whom the diagnosis of mitral stenosis was first discovered in the echocardiography laboratory. Because of this experience, we examined the records of 152 patients with echocardiographic evidence of rheumatic mitral stenos... | cardiovascular diseases |
Abnormal liver enzyme levels. Evaluation in asymptomatic patients. Chronic elevation of serum aminotransferase levels, even in the absence of symptoms, often reflects chronic hepatitis or other significant underlying liver disease. Patients with persistently abnormal alkaline phosphatase levels may have extrahepatic bi... | digestive system diseases |
Predictors of postoperative ventricular dysrhythmias: a multivariate study. Postoperative ventricular dysrhythmias were studied to document their incidence after coronary bypass grafting and to identify risk factors for their development with the hope of finding a subgroup of patients who might benefit from postoperati... | general pathological conditions |
Frontal impairment and hypoperfusion in neuroacanthocytosis. Cerebral blood flow tomography, by xenon 133 inhalation or HMPAO (99mTc-d, l-hexamethyl-propylene amine oxime) technetium Tc 99m injection, revealed a severe hypoperfusion in both frontal lobes of a 40-year-old woman with confirmed neuroacanthocytosis. This f... | nervous system diseases |
Bowel dysfunction in fibromyalgia syndrome. Fibromyalgia and irritable bowel syndrome frequently coexist. In this study, we utilized a previously validated self-administered questionnaire to assess the prevalence of symptoms of bowel dysfunction and irritable bowel syndrome in 123 patients with fibromyalgia as compared... | general pathological conditions |
Blood contacts during surgical procedures Operating room personnel are at risk for infection with blood-borne pathogens through blood contact. To describe the nature and frequency of blood contact and its risk factors, trained observers monitored a sample of operations performed by six surgical services at Grady Memori... | digestive system diseases |
Phase I clinical and pharmacologic study of intraperitoneal cisplatin and fluorouracil in patients with advanced intraabdominal cancer. Fluorouracil (5-FU) and cisplatin display marked therapeutic synergy in preclinical models and are effective in the treatment of a number of solid tumors when combined and administered... | digestive system diseases |
Delayed-onset dystonia due to perinatal or early childhood asphyxia. We report 10 patients with delayed-onset dystonia associated with perinatal asphyxia and 2 associated with asphyxia in childhood. In the perinatal group, the mean age of onset was 12.9 years. Among these patients, dystonia continued to progress for a ... | general pathological conditions |
Myotonic heart disease: a clinical follow-up. We followed 37 patients with myotonic dystrophy for a mean of 6 years. Two developed atrial flutter or fibrillation, 6 developed a new bundle branch block, 1 developed complete heart block requiring a pacemaker, and another with progressive 1st-degree heart block and a wide... | general pathological conditions |
Proliferation and DNA ploidy in malignant breast tumors in relation to early oral contraceptive use and early abortions. In 175 premenopausal breast cancer patients, a history of oral contraceptive (OC) use before 20 years of age was significantly associated with higher tumor cell proliferative activity, as indicated b... | neoplasms |
Vascular abnormalities in epidermal nevus syndrome. We report a patient with epidermal nevus syndrome and right hemispheric infarct and review 3 others with neurologic manifestations best explained by ischemia or hemorrhage. Each had a significant vascular abnormality such as occlusion or blood vessel dysplasia. None h... | cardiovascular diseases |
Management of pseudarthrosis after arthrodesis of the spine for idiopathic scoliosis. Sixty-three first, second, or third-time repairs of one or more pseudarthroses were done in fifty-one patients who had had an arthrodesis for idiopathic scoliosis. Forty-five of the patients were female and six were male. The average ... | nervous system diseases |
Transforming function of proto-ras genes depends on heterologous promoters and is enhanced by specific point mutations [published erratum appears in Proc Natl Acad Sci U S A 1991 May 1;88(9):4059] Based on transfection into cells in culture or natural transduction into retroviruses, proto-ras genes seem to derive trans... | neoplasms |
A longitudinal study of respiratory symptoms in a community population sample. Correlations with smoking, allergen skin-test reactivity, and serum IgE Chronic cough and/or phlegm, wheeze in the absence of colds, and rhinitis attributed to allergies are three of the most common respiratory symptoms encountered in commun... | general pathological conditions |
Renovascular hypertension. Difficulties in diagnosis and treatment. Renovascular hypertension is not easily identified clinically, and most tests are not totally reliable in detecting its presence. The condition may be due to fibromuscular dysplasia or congenital anomalies in patients younger than age 30 or to atherosc... | cardiovascular diseases |
Unusual cerebral manifestations in hereditary fructose intolerance. Five children with hereditary fructose intolerance developed symptoms of neurological impairment. In three of them, neurological involvement was related to the acute hepatic toxicity of fructose (hypoglycemia, abnormal coagulation, cardiovascular colla... | nervous system diseases |
Diffuse hemangiomatosis of the spleen: splenic hemangiomatosis presenting with giant splenomegaly, anemia, and thrombocytopenia. In an elderly patient with oligosymptomatic giant splenomegaly, clinical and laboratory data were nondiagnostic, while nonhomogeneous splenic enlargement was the only finding detected by imag... | neoplasms |
Characterization of liver-associated natural killer cells in patients with liver tumors. The existence of a marginal lymphocyte population in rat liver sinusoids has already been demonstrated using the sinusoidal lavage method. We used the same technique to study the lymphocyte population in human liver obtained ex viv... | neoplasms |
Axial loading injuries to the middle cervical spine segment. An analysis and classification of twenty-five cases. Injuries to the cervical spine at the C3-C4 level involving the bony elements, intervertebral disks, and ligamentous structures are rare. We present 25 cases of traumatic C3-C4 injuries sustained by young a... | nervous system diseases |
Leukemia initiated by hemopoietic stem cells expressing the v-abl oncogene. We report a mouse model with which to study leukemogenesis initiated by a specific genetic change introduced into a primary lymphoid-myeloid pluripotent stem cell. Fetal liver hemopoietic cells were infected with a high titer of helper-free Abe... | general pathological conditions |
Acute hypercalcemic crisis after an open heart operation. Acute hyperparathyroidism developed in a previously normocalcemic 64-year-old woman during the first week after a coronary operation. Prolonged QT interval in the electrocardiogram and hypercalcemia were documented on the fourth postoperative day. Neck explorati... | general pathological conditions |
Silent myocardial ischemia during rehabilitation for cerebrovascular disease. In asymptomatic patients the importance of silent ischemic ST-T wave changes on Holter monitoring is known to be a significant predictive variable for one-year mortality of postmyocardial infarction patients. This case report represents the u... | nervous system diseases |
Human immunodeficiency virus-associated eosinophilic folliculitis. A unique dermatosis associated with advanced human immunodeficiency virus infection. We studied 13 patients with human immunodeficiency virus (HIV) infection and a chronic pruritic folliculitis that was unresponsive to systemic treatment with bactericid... | general pathological conditions |
Hemopump support for the failing heart. Under fluoroscopy, the hemopump is passed through the aortic valve into the left ventricle through a Gortex (WF Gore, Denver, CO) chimney sewn to a surgically exposed femoral artery. The system aspirates the left ventricular blood and actively pumps it into the aorta. Five patien... | cardiovascular diseases |
Signs distinguishing spasmus nutans (with and without central nervous system lesions) from infantile nystagmus. Clinical findings as well as eye and head movement recordings were analyzed from 23 patients with spasmus nutans without central nervous system (CNS) changes, 10 patients with spasmus nutans-like disease (hea... | nervous system diseases |
Clinicopathologic studies of children who die of acute lower respiratory tract infections: mechanisms of death. Clinicopathologic correlations for 71 cases of fatal pneumonia in children were determined. The mechanism of death for these patients was multifactorial. Severe pneumonia alone accounted for 11 deaths (15.5%)... | cardiovascular diseases |
The interferon system in carcinoma of the cervix. Effect of radiation and chemotherapy. Thirteen patients with advanced carcinoma of the cervix were studied for parameters of the interferon system compared with 40 age-matched and sex-matched controls. All patients had measurable serum interferon levels; controls did no... | neoplasms |
An overview of randomized trials of sodium reduction and blood pressure To test for effects on systolic and diastolic blood pressure and to provide precise estimates of their magnitude, we conducted an overview of randomized clinical trials that aimed to reduce the intake of sodium in human subjects. We excluded from p... | cardiovascular diseases |
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