screen_file
string | organism
string | perturbation
string | gene
string | cell
string | phenotype
string | hit
int64 | benchmark_type
string | prompt
string | gene_context
string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mta2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mta2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mta2 (metastasis-associated gene family, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, chromosome organization, genomic imprinting, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell fate specification, regulation of fibroblast migration, regulation of stem cell differentiation; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone deacetylase activity, histone deacetylase binding, metal ion binding, protein binding, sequence-specific DNA binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity, zinc ion binding; CC: NuRD complex, catalytic complex, chromosome, telomeric region, histone deacetylase complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Signal Transduction, Transcriptional Regulation by TP53
UniProt: Q9R190
Entrez ID: 23942
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tpi1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tpi1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tpi1 (triosephosphate isomerase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, gluconeogenesis, glucose metabolic process, glyceraldehyde-3-phosphate biosynthetic process, glyceraldehyde-3-phosphate metabolic process, glycerol catabolic process, glycolytic process, methylglyoxal biosynthetic process; MF: isomerase activity, lyase activity, methylglyoxal synthase activity, protein binding, protein homodimerization activity, triose-phosphate isomerase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol
Pathways: Fructose and mannose metabolism - Mus musculus (mouse), Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, glycolysis I, glycolysis III, glycolysis V (Pyrococcus), sucrose degradation V (mammalian)
UniProt: P17751
Entrez ID: 21991
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Atxn7l3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Atxn7l3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Atxn7l3 (ataxin 7-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing, regulation of transcription by RNA polymerase II; MF: metal ion binding, transcription coactivator activity, zinc ion binding; CC: DUBm complex, SAGA complex, SAGA-type complex, nucleus, transcription factor TFTC complex
Pathways:
UniProt: A2AWT3
Entrez ID: 217218
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Fam98b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Fam98b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Fam98b (family with sequence similarity 98, member B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell population proliferation, positive regulation of gene expression, protein methylation; MF: identical protein binding, protein methyltransferase activity; CC: cytoplasm, nucleoplasm, nucleus, tRNA-splicing ligase complex
Pathways:
UniProt: Q80VD1
Entrez ID: 68215
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Heatr3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Heatr3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Heatr3 (HEAT repeat containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: erythrocyte maturation, protein import into nucleus, ribosomal large subunit biogenesis, ribosome biogenesis
Pathways:
UniProt: Q8BQM4
Entrez ID: 234549
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pds5b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pds5b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pds5b (PDS5 cohesin associated factor B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, lens development in camera-type eye, mitotic sister chromatid cohesion, negative regulation of cell population proliferation, regulation of cell population proliferation; MF: DNA binding, cohesin unloader activity; CC: chromatin, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cohesin Loading onto Chromatin, Establishment of Sister Chromatid Cohesion, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Telophase/Cytokinesis, Resolution of Sister Chromatid Cohesion, S Phase, Separation of Sister Chromatids
UniProt: Q4VA53
Entrez ID: 100710
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gnl3l
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gnl3l in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gnl3l (guanine nucleotide binding protein nucleolar 3 like)
Type: protein-coding
Summary: Predicted to enable GTP binding activity. Predicted to be involved in several processes, including negative regulation of protein modification by small protein conjugation or removal; negative regulation of telomere maintenance via telomerase; and positive regulation of protein localization to chromosome, telomeric region. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in nucleolus. Orthologous to human GNL3L (G protein nucleolar 3 like). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of protein sumoylation, negative regulation of protein ubiquitination, negative regulation of telomere maintenance via telomerase, positive regulation of protein localization to chromosome, telomeric region, positive regulation of protein-containing complex assembly, regulation of protein stability, ribosome biogenesis; MF: GTP binding, nucleotide binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, telomerase holoenzyme complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q6PGG6
Entrez ID: 237107
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Haus1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Haus1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Haus1 (HAUS augmin-like complex, subunit 1)
Type: protein-coding
Summary: Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain ventricular layer; chondrocranium; liver lobe; and submandibular gland primordium. Orthologous to human HAUS1 (HAUS augmin like complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell division, centrosome cycle, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle microtubule, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q8BHX1
Entrez ID: 225745
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Taf11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Taf11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Taf11 (TATA-box binding protein associated factor 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, host-mediated activation of viral transcription, mRNA transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, protein binding, protein heterodimerization activity, transcription coactivator activity; CC: Golgi apparatus, nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q99JX1
Entrez ID: 68776
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Strap
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Strap in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Strap (serine/threonine kinase receptor associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, maintenance of gastrointestinal epithelium, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, neuron differentiation, protein-RNA complex assembly, retinoic acid catabolic process, retinoic acid receptor signaling pathway, spliceosomal snRNP assembly; MF: RNA binding, U2 snRNP binding, mRNA binding, protein binding, signaling receptor binding; CC: SMN complex, SMN-Sm protein complex, cytoplasm, cytosol, nucleus
Pathways: Downregulation of TGF-beta receptor signaling, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs
UniProt: Q9Z1Z2
Entrez ID: 20901
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Heatr1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Heatr1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Heatr1 (HEAT repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), neural precursor cell proliferation, positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, protein localization to nucleolus, rRNA metabolic process, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; CC: 90S preribosome, fibrillar center, mitochondrion, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome, t-UTP complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: A0A1Y7VNI1, G3X9B1, A0A1Y7VNG8
Entrez ID: 217995
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Birc5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Birc5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Birc5 (baculoviral IAP repeat-containing 5)
Type: protein-coding
Summary: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, apoptotic process, cell division, chromosome localization, chromosome segregation, meiosis I, microtubule cytoskeleton organization, mitotic cell cycle, mitotic cytokinesis, mitotic spindle assembly checkpoint signaling, mitotic spindle midzone assembly, mitotic spindle organization, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of neuron apoptotic process, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of cell cycle, positive regulation of exit from mitosis, positive regulation of mitotic cell cycle, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of mitotic cytokinesis, positive regulation of mitotic sister chromatid separation, positive regulation of protein ubiquitination, protein-containing complex localization, regulation of cell cycle, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of mitotic cell cycle, regulation of type B pancreatic cell proliferation; MF: cysteine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, enzyme binding, identical protein binding, metal ion binding, microtubule binding, peptidase inhibitor activity, protein binding, protein heterodimerization activity, protein homodimerization activity, protein-folding chaperone binding, small GTPase binding, tubulin binding, ubiquitin protein ligase activity, zinc ion binding; CC: apical plasma membrane, centriole, chromosome, chromosome passenger complex, chromosome, centromeric region, cytoplasm, cytoplasmic microtubule, cytoskeleton, cytosol, interphase microtubule organizing center, kinetochore, microtubule, microtubule cytoskeleton, midbody, nuclear chromosome, nucleus, protein-containing complex, spindle, spindle microtubule, survivin complex
Pathways: Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse)
UniProt: O70201
Entrez ID: 11799
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Wdr5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Wdr5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Wdr5 (WD repeat domain 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of transcription by RNA polymerase II, neuron projection development, positive regulation of DNA-templated transcription, positive regulation of gluconeogenesis, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II, skeletal system development, transcription initiation-coupled chromatin remodeling; MF: histone H3K4 methyltransferase activity, histone H3K4me1 reader activity, histone H3Q5ser reader activity, histone binding, protein binding; CC: ATAC complex, MLL1 complex, MLL1/2 complex, MLL3/4 complex, NSL complex, Set1C/COMPASS complex, histone acetyltransferase complex, histone methyltransferase complex, mitotic spindle, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Cushing syndrome - Mus musculus (mouse), Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, Metabolism of proteins, Neddylation, PKMTs methylate histone lysines, Post-translational protein modification, RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Transcriptional regulation by RUNX1
UniProt: P61965
Entrez ID: 140858
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nip7
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nip7 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nip7 (NIP7, nucleolar pre-rRNA processing protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome assembly, ribosome biogenesis; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CXK8
Entrez ID: 66164
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Psmc5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Psmc5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Psmc5 (protease (prosome, macropain) 26S subunit, ATPase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, positive regulation of inclusion body assembly, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of transcription by RNA polymerase II; MF: ATP binding, ATP hydrolysis activity, DNA-binding transcription factor binding, TBP-class protein binding, general transcription initiation factor binding, nucleotide binding, proteasome-activating activity, protein binding, signaling receptor binding, thyrotropin-releasing hormone receptor binding; CC: cytoplasm, cytoplasmic vesicle, cytosolic proteasome complex, inclusion body, nuclear proteasome complex, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, base subcomplex, transcription factor TFIIH holo complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P62196
Entrez ID: 19184
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ppcdc
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ppcdc in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ppcdc (phosphopantothenoylcysteine decarboxylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: coenzyme A biosynthetic process; MF: FMN binding, carboxy-lyase activity, catalytic activity, identical protein binding, lyase activity, phosphopantothenoylcysteine decarboxylase activity
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q8BZB2
Entrez ID: 66812
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cbll1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cbll1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cbll1 (Casitas B-lineage lymphoma-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell adhesion, mRNA processing, negative regulation of cell adhesion, positive regulation of cell migration, positive regulation of endocytosis, protein ubiquitination, regulation of cell adhesion; MF: identical protein binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: RNA N6-methyladenosine methyltransferase complex, cytoplasm, nuclear speck, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Adherens junctions interactions, Antigen processing: Ubiquitination & Proteasome degradation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Class I MHC mediated antigen processing & presentation, Degradation of CDH1, Immune System, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q9JIY2
Entrez ID: 104836
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Vars2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Vars2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Vars2 (valyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aminoacyl-tRNA metabolism involved in translational fidelity, tRNA aminoacylation for protein translation, translation, valyl-tRNA aminoacylation; MF: ATP binding, aminoacyl-tRNA deacylase activity, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, valine-tRNA ligase activity; CC: cytosol, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q3U2A8
Entrez ID: 68915
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl38
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl38 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl38 (mitochondrial ribosomal protein L38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q8K2M0
Entrez ID: 60441
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hsd17b10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Hsd17b10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hsd17b10 (hydroxysteroid (17-beta) dehydrogenase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: C21-steroid hormone metabolic process, L-isoleucine catabolic process, androgen metabolic process, bile acid biosynthetic process, brexanolone metabolic process, estrogen metabolic process, fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process, mitochondrial tRNA 3'-end processing, mitochondrial tRNA 5'-end processing, mitochondrial tRNA methylation, mitochondrion organization, protein homotetramerization, steroid metabolic process, tRNA processing; MF: (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity, 17-beta-hydroxysteroid dehydrogenase (NAD+) activity, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity, NAD binding, acetoacetyl-CoA reductase activity, amyloid-beta binding, androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity, chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity, cholate 7-alpha-dehydrogenase (NAD+) activity, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, identical protein binding, isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity, nuclear estrogen receptor binding, oxidoreductase activity, steroid binding, tRNA binding, testosterone dehydrogenase (NAD+) activity, ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity; CC: endoplasmic reticulum, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrial ribonuclease P complex, mitochondrion, tRNA methyltransferase complex
Pathways: 2-methylbutyrate biosynthesis, Alzheimer disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway), isoleucine degradation
UniProt: A2AFQ2, Q99N15
Entrez ID: 15108
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pyroxd1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pyroxd1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pyroxd1 (pyridine nucleotide-disulphide oxidoreductase domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress; MF: NAD(P)H oxidase H2O2-forming activity, molecular_function, oxidoreductase activity; CC: cytoplasm, nucleus, sarcomere
Pathways:
UniProt: Q3TMV7
Entrez ID: 232491
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Timm10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Timm10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Timm10 (translocase of inner mitochondrial membrane 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein transport; MF: membrane insertase activity, metal ion binding, protein homodimerization activity, protein-folding chaperone binding; CC: TIM22 mitochondrial import inner membrane insertion complex, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial intermembrane space chaperone complex, mitochondrion
Pathways:
UniProt: P62073
Entrez ID: 30059
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrps15
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrps15 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrps15 (mitochondrial ribosomal protein S15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrial small ribosomal subunit, mitochondrion, nucleolus, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DC71
Entrez ID: 66407
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Toe1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Toe1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Toe1 (target of EGR1, member 1 (nuclear))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA metabolic process, snRNA 3'-end processing; MF: 3'-5'-RNA exonuclease activity, metal ion binding, nucleic acid binding, poly(A)-specific ribonuclease activity, snRNA binding, zinc ion binding; CC: Cajal body, cytoplasm, nuclear body, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9D2E2
Entrez ID: 68276
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nudcd2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nudcd2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nudcd2 (NudC domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, intercellular bridge, kinetochore, microtubule cytoskeleton, mitotic spindle, spindle pole
Pathways:
UniProt: Q9CQ48
Entrez ID: 52653
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nufip1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nufip1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nufip1 (nuclear FMR1 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box C/D snoRNP assembly, positive regulation of transcription by RNA polymerase II; MF: ATPase binding, RNA binding, identical protein binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, snoRNA binding, zinc ion binding; CC: fibrillar center, nuclear matrix, nucleolus, nucleoplasm, nucleus, perichromatin fibrils, pre-snoRNP complex, presynaptic active zone, protein-containing complex, synapse, transcription elongation factor complex
Pathways:
UniProt: Q9QXX8
Entrez ID: 27275
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dhx33
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dhx33 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dhx33 (DEAH-box helicase 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of MAPK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of transcription by RNA polymerase I, positive regulation of type I interferon production, translational initiation; MF: ATP binding, ATP hydrolysis activity, DNA-binding transcription factor binding, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, rDNA binding, ribosomal large subunit binding; CC: NLRP3 inflammasome complex, canonical inflammasome complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q80VY9
Entrez ID: 216877
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Noc4l
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Noc4l in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Noc4l (NOC4 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Noc4p-Nop14p complex, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8BHY2
Entrez ID: 100608
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ndufa1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ndufa1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ndufa1 (NADH:ubiquinone oxidoreductase subunit A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: O35683
Entrez ID: 54405
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps27rt
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps27rt in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps27rt (ribosomal protein S27, retrogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cap-dependent Translation Initiation, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Coronavirus disease - COVID-19 - Mus musculus (mouse), EML4 and NUDC in mitotic spindle formation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, M Phase, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6ZWU9
Entrez ID: 100043813
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tiprl
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tiprl in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tiprl (TIP41, TOR signalling pathway regulator-like (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, TOR signaling; MF: molecular_function, protein phosphatase activator activity, protein phosphatase inhibitor activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q8BH58
Entrez ID: 226591
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nat10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nat10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nat10 (N-acetyltransferase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, negative regulation of telomere maintenance via telomerase, positive regulation of translation, protein acetylation, rRNA acetylation involved in maturation of SSU-rRNA, rRNA metabolic process, rRNA modification, rRNA processing, regulation of centrosome duplication, regulation of translation, ribosomal small subunit biogenesis, ribosome biogenesis, tRNA acetylation, tRNA processing, tRNA wobble cytosine modification; MF: 18S rRNA cytidine N-acetyltransferase activity, ATP binding, DNA polymerase binding, N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, mRNA N-acetyltransferase activity, nucleotide binding, tRNA binding, tRNA cytidine N4-acetyltransferase activity, transferase activity; CC: midbody, nucleolus, nucleus, small-subunit processome, telomerase holoenzyme complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q8K224
Entrez ID: 98956
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Flii
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Flii in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Flii (flightless I actin binding protein)
Type: protein-coding
Summary: This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: actin cytoskeleton organization, actin filament severing, actin polymerization or depolymerization, barbed-end actin filament capping, myofibril assembly, sarcomere organization; MF: actin binding, actin filament binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: actin cytoskeleton, anchoring junction, brush border, cell projection, centriolar satellite, centrosome, cytoplasm, cytoskeleton, cytosol, focal adhesion, nucleoplasm, nucleus, podosome
Pathways:
UniProt: Q9JJ28
Entrez ID: 14248
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eral1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eral1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eral1 (Era like 12S mitochondrial rRNA chaperone 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal small subunit assembly, ribosome biogenesis; MF: GTP binding, RNA binding, nucleotide binding, rRNA binding, ribosomal small subunit binding; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CZU4
Entrez ID: 57837
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tsr1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tsr1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tsr1 (TSR1 20S rRNA accumulation)
Type: protein-coding
Summary: Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Orthologous to human TSR1 (TSR1 ribosome maturation factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosome biogenesis; MF: GTP binding, GTPase activity, U3 snoRNA binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q5SWD9
Entrez ID: 104662
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ing1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ing1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ing1 (inhibitor of growth family, member 1)
Type: protein-coding
Summary: Predicted to enable methylated histone binding activity. Acts upstream of or within positive regulation of DNA-templated transcription; protein import into nucleus; and regulation of programmed cell death. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to human ING1 (inhibitor of growth family member 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: chromatin organization, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of stem cell population maintenance, protein import into nucleus, regulation of programmed cell death; MF: histone H3K4me3 reader activity, metal ion binding, zinc ion binding; CC: Sin3-type complex, nucleus
Pathways:
UniProt: Q9QXV3
Entrez ID: 26356
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl37
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl37 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl37 (ribosomal protein L37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, positive regulation of signal transduction by p53 class mediator, translation, translation at postsynapse, translation at presynapse; MF: MDM2/MDM4 family protein binding, RNA binding, growth factor binding, metal ion binding, rRNA binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity, zinc ion binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D823
Entrez ID: 67281
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nop10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nop10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nop10 (NOP10 ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: pseudouridine synthesis, rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis, snoRNA guided rRNA pseudouridine synthesis, telomere maintenance via telomerase; MF: RNA binding, box H/ACA snoRNA binding, protein binding, snoRNA binding, telomerase RNA binding; CC: Cajal body, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, nuclear body, nucleolus, nucleus, ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q9CQS2
Entrez ID: 66181
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrps34
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrps34 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrps34 (mitochondrial ribosomal protein S34)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; genitourinary system; heart; liver; and thymus primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 32. Orthologous to human MRPS34 (mitochondrial ribosomal protein S34). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9JIK9
Entrez ID: 79044
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cpsf4
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cpsf4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cpsf4 (cleavage and polyadenylation specific factor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, metal ion binding, nucleic acid binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Influenza A - Mus musculus (mouse), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8BQZ5
Entrez ID: 54188
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Wdr25
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Wdr25 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Wdr25 (WD repeat domain 25)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q349
Entrez ID: 212198
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps10 (ribosomal protein S10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit assembly, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome, tRNA binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63325
Entrez ID: 67097
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dars2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dars2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dars2 (aspartyl-tRNA synthetase 2 (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aspartyl-tRNA aminoacylation, mitochondrial asparaginyl-tRNA aminoacylation, tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, aspartate-tRNA ligase activity, aspartate-tRNA(Asn) ligase activity, ligase activity, nucleic acid binding, nucleotide binding, protein homodimerization activity; CC: cytoplasm, membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8BIP0
Entrez ID: 226539
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl44
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl44 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl44 (mitochondrial ribosomal protein L44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, mitochondrial translation, mitochondrial translational elongation; MF: RNA binding, double-stranded RNA binding, endonuclease activity, hydrolase activity, nuclease activity, protein binding, ribonuclease III activity; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrion, nuclear body, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CY73
Entrez ID: 69163
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pabpn1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pabpn1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pabpn1 (poly(A) binding protein, nuclear 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, cellular response to lipopolysaccharide, mRNA processing, poly(A)+ mRNA export from nucleus, positive regulation of polynucleotide adenylyltransferase activity, regulation of mRNA 3'-end processing; MF: RNA binding, RNA polymerase binding, identical protein binding, nucleic acid binding, poly(A) binding, protein binding; CC: cytoplasm, cytosol, nuclear inclusion body, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Influenza A - Mus musculus (mouse), Metabolism of RNA, Nuclear RNA decay, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8CCS6
Entrez ID: 54196
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif5 (eukaryotic translation initiation factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: formation of cytoplasmic translation initiation complex, regulation of translational initiation, ribosome assembly, translation, translational initiation; MF: GDP-dissociation inhibitor activity, GTP binding, GTPase activator activity, eukaryotic initiation factor eIF2 binding, nucleotide binding, translation initiation factor activity; CC: cytoplasm, cytosol, plasma membrane, synapse
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation
UniProt: P59325
Entrez ID: 217869
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rfk
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rfk in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rfk (riboflavin kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: FMN biosynthetic process, apoptotic process, flavin adenine dinucleotide biosynthetic process, reactive oxygen species metabolic process, riboflavin biosynthetic process, riboflavin metabolic process; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, riboflavin kinase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Riboflavin metabolism - Mus musculus (mouse), Vitamin B2 (riboflavin) metabolism, flavin biosynthesis IV (mammalian), riboflavin, FMN and FAD transformations
UniProt: Q8CFV9
Entrez ID: 54391
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nup98
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nup98 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nup98 (nucleoporin 98)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nuclear pore complex assembly, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, positive regulation of mRNA splicing, via spliceosome, post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, protein import into nucleus, protein transport, proteolysis, telomere tethering at nuclear periphery; MF: RNA binding, hydrolase activity, mRNA binding, molecular condensate scaffold activity, nuclear localization sequence binding, peptidase activity, peptide binding, promoter-specific chromatin binding, serine-type peptidase activity, structural constituent of nuclear pore, transcription coactivator activity; CC: kinetochore, membrane, nuclear body, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nuclear pore outer ring, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Influenza A - Mus musculus (mouse), Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q6PFD9
Entrez ID: 269966
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Srd5a3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Srd5a3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Srd5a3 (steroid 5 alpha-reductase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, dolichyl monophosphate biosynthetic process, lipid metabolic process, polyprenol catabolic process, protein glycosylation; MF: 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor, polyprenal reductase activity, polyprenol reductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Androgen biosynthesis, Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroid hormones, Metabolism of steroids, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Steroid hormone biosynthesis - Mus musculus (mouse), Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis
UniProt: Q9WUP4
Entrez ID: 57357
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif4b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif4b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif4b (eukaryotic translation initiation factor 4B)
Type: protein-coding
Summary: Predicted to enable RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Predicted to be located in cytosol; dendrite; and neuronal cell body. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: eukaryotic translation initiation factor 4F complex assembly, formation of translation preinitiation complex, translation, translational initiation; MF: RNA binding, RNA strand annealing activity, RNA strand-exchange activity, nucleic acid binding, ribosomal small subunit binding, translation initiation factor activity; CC: cytosol, dendrite, neuronal cell body, postsynapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, MTOR signalling, Metabolism of RNA, Metabolism of proteins, PI3K-Akt signaling pathway - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Ribosomal scanning and start codon recognition, Signal Transduction, Translation, Translation initiation complex formation, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q8BGD9
Entrez ID: 75705
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Lsm11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Lsm11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Lsm11 (U7 snRNP-specific Sm-like protein LSM11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle, regulation of chromatin organization; MF: RNA binding, U7 snRNA binding, protein binding; CC: U7 snRNP, histone pre-mRNA 3'end processing complex, nuclear body, nucleoplasm, nucleus, ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs
UniProt: Q8BUV6
Entrez ID: 72290
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl17
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl17 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl17 (ribosomal protein L17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to amino acid starvation, cytoplasmic translation, positive regulation of G1/S transition of mitotic cell cycle, response to amino acid starvation, translation, translation at postsynapse, translation at presynapse; MF: large ribosomal subunit rRNA binding, protein binding, structural constituent of ribosome; CC: A band, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CPR4
Entrez ID: 319195
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sephs2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sephs2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sephs2 (selenophosphate synthetase 2)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. [provided by RefSeq, May 2017].
Gene Ontology: BP: selenium compound metabolic process, selenocysteine biosynthetic process, selenocysteine metabolic process; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, selenide, water dikinase activity, transferase activity
Pathways: Metabolism, Metabolism of amino acids and derivatives, Selenoamino acid metabolism, Selenocompound metabolism - Mus musculus (mouse), Selenocysteine synthesis, selenocysteine biosynthesis II (archaea and eukaryotes)
UniProt: P97364
Entrez ID: 20768
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Adat3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Adat3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Adat3 (adenosine deaminase, tRNA-specific 3)
Type: protein-coding
Summary: Predicted to enable catalytic activity and metal ion binding activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA processing. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: MF: catalytic activity, metal ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q6PAT0
Entrez ID: 100113398
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Aasdhppt
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Aasdhppt in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 10-formyltetrahydrofolate catabolic process, lysine biosynthetic process via aminoadipic acid, protein maturation; MF: holo-[acyl-carrier-protein] synthase activity, magnesium ion binding, metal ion binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism
UniProt: Q9CQF6
Entrez ID: 67618
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sars2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sars2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sars2 (seryl-aminoacyl-tRNA synthetase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial seryl-tRNA aminoacylation, seryl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, serine-tRNA ligase activity, tRNA binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), selenocysteine biosynthesis II (archaea and eukaryotes), tRNA charging pathway
UniProt: Q9JJL8
Entrez ID: 71984
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dhodh
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dhodh in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dhodh (dihydroorotate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, positive regulation of apoptotic process, pyrimidine nucleotide biosynthetic process, pyrimidine ribonucleotide biosynthetic process, pyrimidine-containing compound biosynthetic process, regulation of mitochondrial fission; MF: FMN binding, dihydroorotase activity, dihydroorotate dehydrogenase (quinone) activity, dihydroorotate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, quinone binding, ubiquinone binding; CC: cytoplasm, cytosol, membrane, mitochondrial inner membrane, mitochondrion, neuronal cell body, nucleoplasm
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Pyrimidine biosynthesis, Pyrimidine metabolism - Mus musculus (mouse)
UniProt: O35435
Entrez ID: 56749
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ubtf
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ubtf in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ubtf (upstream binding transcription factor, RNA polymerase I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, cellular response to leukemia inhibitory factor, positive regulation of transcription by RNA polymerase I, rDNA heterochromatin formation, transcription by RNA polymerase I, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase I promoter; MF: DNA binding, RNA polymerase I cis-regulatory region sequence-specific DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase I general transcription initiation factor activity, chromatin binding, protein binding, scaffold protein binding; CC: fibrillar center, nucleolus, nucleus
Pathways:
UniProt: A2AWT5, A2AWT6, E9Q4A8, A2AWT7, Q9DBH1, G3UZW9
Entrez ID: 21429
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nelfcd
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nelfcd in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nelfcd (negative elongation factor complex member C/D, Th1l)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription elongation by RNA polymerase II; MF: RNA binding, protein binding; CC: NELF complex, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q922L6
Entrez ID: 57314
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Atl2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Atl2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Atl2 (atlastin GTPase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, cellular response to type II interferon, endoplasmic reticulum membrane fusion, endoplasmic reticulum organization, endoplasmic reticulum tubular network membrane organization, protein homooligomerization; MF: GTP binding, GTPase activity, GTPase-dependent fusogenic activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network membrane, membrane
Pathways:
UniProt: Q6PA06
Entrez ID: 56298
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pin1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pin1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pin1 (peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, cellular response to hypoxia, negative regulation of ERK1 and ERK2 cascade, negative regulation of SMAD protein signal transduction, negative regulation of amyloid-beta formation, negative regulation of brown fat cell differentiation, negative regulation of cell motility, negative regulation of neuron apoptotic process, negative regulation of protein catabolic process, negative regulation of transforming growth factor beta receptor signaling pathway, neuron differentiation, positive regulation of canonical Wnt signaling pathway, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of neuron apoptotic process, positive regulation of transcription by RNA polymerase II, protein destabilization, protein peptidyl-prolyl isomerization, protein stabilization, protein targeting to mitochondrion, regulation of cell population proliferation, regulation of cytokinesis, regulation of gene expression, regulation of protein localization to nucleus, regulation of protein stability, regulation protein catabolic process at postsynapse, response to hypoxia, synapse organization; MF: GTPase activating protein binding, beta-catenin binding, cis-trans isomerase activity, cytoskeletal motor activity, isomerase activity, mitogen-activated protein kinase kinase binding, peptidyl-prolyl cis-trans isomerase activity, phosphoprotein binding, phosphoserine residue binding, phosphothreonine residue binding, protein binding, ubiquitin ligase activator activity; CC: cytoplasm, cytosol, glutamatergic synapse, midbody, nuclear speck, nucleoplasm, nucleus, postsynapse, postsynaptic cytosol
Pathways: DDX58/IFIH1-mediated induction of interferon-alpha/beta, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Negative regulators of DDX58/IFIH1 signaling, PI5P Regulates TP53 Acetylation, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, RIG-I-like receptor signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional Regulation by TP53
UniProt: Q9QUR7
Entrez ID: 23988
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cmtr2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cmtr2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cmtr2 (cap methyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 7-methylguanosine mRNA capping, mRNA processing, methylation; MF: methyltransferase activity, methyltransferase cap1 activity, methyltransferase cap2 activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8BWQ4
Entrez ID: 234728
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps15
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps15 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps15 (ribosomal protein S15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, liver regeneration, positive regulation of signal transduction by p53 class mediator, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus, translation; MF: MDM2/MDM4 family protein binding, RNA binding, protein binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleoplasm, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62843
Entrez ID: 20054
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zcchc9
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Zcchc9 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zcchc9 (zinc finger, CCHC domain containing 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, nucleic acid binding, zinc ion binding; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8R1J3
Entrez ID: 69085
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eef1g
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eef1g in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eef1g (eukaryotic translation elongation factor 1 gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: response to virus, translation, translational elongation; CC: cytoplasm, endoplasmic reticulum, nucleus
Pathways: Eukaryotic Translation Elongation, Legionellosis - Mus musculus (mouse), Metabolism of proteins, Translation
UniProt: Q9D8N0
Entrez ID: 67160
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl20
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl20 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl20 (mitochondrial ribosomal protein L20)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including extraembryonic component; ganglia; genitourinary system; jaw; and musculoskeletal system. Orthologous to human MRPL20 (mitochondrial ribosomal protein L20). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, translation; MF: rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CQL4
Entrez ID: 66448
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Wdr77
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Wdr77 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Wdr77 (WD repeat domain 77)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation involved in prostate gland development, oocyte axis specification, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of mRNA splicing, via spliceosome, protein polyubiquitination, regulation of transcription by RNA polymerase II, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, spliceosomal snRNP assembly, ubiquitin-dependent protein catabolic process; MF: methyl-CpG binding, protein binding, transcription coactivator activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul4B-RING E3 ubiquitin ligase complex, Golgi apparatus, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, transferase complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Metabolism of RNA, Metabolism of non-coding RNA, RMTs methylate histone arginines, snRNP Assembly
UniProt: Q99J09
Entrez ID: 70465
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl3 (ribosomal protein L3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-4, cytoplasmic translation, translation; MF: 5S rRNA binding, RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleolus, nucleus, protein-containing complex, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P27659
Entrez ID: 27367
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Chordc1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Chordc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Chordc1 (cysteine and histidine rich domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: centrosome duplication, negative regulation of Rho-dependent protein serine/threonine kinase activity, protein folding, regulation of cellular response to heat, regulation of centrosome duplication; MF: ADP binding, ATP binding, Hsp90 protein binding, metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q9D1P4
Entrez ID: 66917
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mettl23
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mettl23 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mettl23 (methyltransferase like 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, cognition, epigenetic programing of male pronucleus, epigenetic programming in the zygotic pronuclei, epigenetic regulation of gene expression, methylation, positive regulation of transcription by RNA polymerase II, regulation of gene expression; MF: DNA-binding transcription factor binding, heat shock protein binding, histone H3R17 methyltransferase activity, histone methyltransferase activity, methyltransferase activity, protein binding, protein methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, transferase activity; CC: cytoplasm, female pronucleus, male pronucleus, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: A2AA28
Entrez ID: 74319
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cstf3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cstf3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cstf3 (cleavage stimulation factor, 3' pre-RNA, subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, RNA processing, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA processing; CC: mRNA cleavage stimulating factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q99LI7
Entrez ID: 228410
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Alad
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Alad in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Alad (aminolevulinate, delta-, dehydratase)
Type: protein-coding
Summary: Enables porphobilinogen synthase activity. Involved in heme A biosynthetic process; heme B biosynthetic process; and heme O biosynthetic process. Acts upstream of or within cellular response to interleukin-4 and heme biosynthetic process. Is active in cytosol. Is expressed in several structures, including liver; lung; metanephros; spleen; and yolk sac. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cellular response to interleukin-4, cellular response to lead ion, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, negative regulation of proteasomal protein catabolic process, porphyrin-containing compound biosynthetic process, protein homooligomerization, protoporphyrinogen IX biosynthetic process, response to activity, response to aluminum ion, response to amino acid, response to arsenic-containing substance, response to cadmium ion, response to cobalt ion, response to ethanol, response to fatty acid, response to glucocorticoid, response to herbicide, response to hormone, response to hypoxia, response to ionizing radiation, response to iron ion, response to lead ion, response to lipopolysaccharide, response to mercury ion, response to metal ion, response to methylmercury, response to nutrient, response to nutrient levels, response to oxidative stress, response to platinum ion, response to selenium ion, response to toxic substance, response to vitamin, response to vitamin B1, response to vitamin E, response to xenobiotic stimulus, response to zinc ion, tetrapyrrole biosynthetic process; MF: catalytic activity, identical protein binding, lyase activity, metal ion binding, porphobilinogen synthase activity, proteasome core complex binding, zinc ion binding; CC: cytoplasm, cytosol, extracellular space
Pathways: Heme biosynthesis, Immune System, Innate Immune System, Metabolism, Metabolism of porphyrins, Neutrophil degranulation, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, tetrapyrrole biosynthesis II
UniProt: P10518
Entrez ID: 17025
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif3b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif3b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif3b (eukaryotic translation initiation factor 3, subunit B)
Type: protein-coding
Summary: Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in several structures, including central nervous system; extraembryonic component; and sensory organ. Orthologous to human EIF3B (eukaryotic translation initiation factor 3 subunit B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, regulation of translational initiation, translation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, nucleic acid binding, protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytoplasmic stress granule, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q8JZQ9
Entrez ID: 27979
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Vps11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Vps11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Vps11 (VPS11, CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome organization, endosome to lysosome transport, intracellular protein transport, negative regulation of intracellular estrogen receptor signaling pathway, organelle fusion, positive regulation of early endosome to late endosome transport, positive regulation of protein catabolic process, protein transport, protein ubiquitination, regulation of organelle assembly, vacuole organization, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: metal ion binding, nucleotide binding, protein binding, protein domain specific binding, protein-macromolecule adaptor activity, syntaxin binding, ubiquitin protein ligase activity, zinc ion binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endocytic vesicle, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, presynaptic active zone, vesicle tethering complex
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q91W86
Entrez ID: 71732
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mms19
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mms19 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mms19 (MMS19 cytosolic iron-sulfur assembly component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromosome segregation, positive regulation of DNA-templated transcription, protein maturation; MF: enzyme binding, nuclear estrogen receptor binding, transcription coactivator activity; CC: MMXD complex, cytoplasm, cytoskeleton, cytosol, cytosolic [4Fe-4S] assembly targeting complex, nucleoplasm, nucleus, spindle
Pathways:
UniProt: Q9D071
Entrez ID: 72199
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ctr9
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ctr9 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ctr9 (CTR9 homolog, Paf1/RNA polymerase II complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, blastocyst growth, blastocyst hatching, cell surface receptor signaling pathway via JAK-STAT, cellular response to lipopolysaccharide, chromatin organization, endodermal cell fate commitment, inner cell mass cell differentiation, interleukin-6-mediated signaling pathway, negative regulation of gene expression, epigenetic, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II, trophectodermal cell differentiation; MF: RNA polymerase II complex binding, SH2 domain binding, protein binding; CC: Cdc73/Paf1 complex, euchromatin, nuclear speck, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q62018
Entrez ID: 22083
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Snrpg
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Snrpg in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Snrpg (small nuclear ribonucleoprotein polypeptide G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding; CC: P granule, SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type prespliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, precatalytic spliceosome, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62309
Entrez ID: 68011
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dnajc2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dnajc2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dnajc2 (DnaJ heat shock protein family (Hsp40) member C2)
Type: protein-coding
Summary: Predicted to enable several functions, including Hsp70 protein binding activity; ribosome binding activity; and ubiquitin-modified histone reader activity. Acts upstream of or within DNA replication and negative regulation of DNA biosynthetic process. Predicted to be located in cytoplasm; nuclear membrane; and nucleolus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; blastocyst; brain; hemolymphoid system gland; and reproductive system. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: 'de novo' cotranslational protein folding, DNA replication, chromatin organization, negative regulation of DNA biosynthetic process, negative regulation of cell growth, positive regulation of DNA-templated transcription, regulation of translational fidelity; MF: Hsp70 protein binding, chromatin binding, histone binding, protein binding, ribosome binding, ubiquitin-modified histone reader activity; CC: cytoplasm, cytosol, nuclear membrane, nucleolus, nucleus
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: P54103
Entrez ID: 22791
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tpt1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tpt1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tpt1 (tumor protein, translationally-controlled 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of ectoderm development, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, response to virus, spermatogenesis, stem cell population maintenance; MF: DNA-binding transcription factor binding, calcium ion binding, protein binding; CC: cytoplasm, cytoplasmic microtubule, cytosol, extracellular space, multivesicular body, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: P63028
Entrez ID: 22070
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cdk2ap1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cdk2ap1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cdk2ap1 (cyclin dependent kinase 2 associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: face morphogenesis, in utero embryonic development, regulation of transcription by RNA polymerase II; CC: NuRD complex, chromatin, chromosome, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: O35207
Entrez ID: 13445
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ruvbl1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ruvbl1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ruvbl1 (RuvB-like AAA ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, box C/D snoRNP assembly, cell division, chromatin organization, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of canonical Wnt signaling pathway, positive regulation of double-strand break repair via homologous recombination, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of chromosome organization, regulation of double-strand break repair, regulation of embryonic development, regulation of transcription by RNA polymerase II, telomere maintenance; MF: 3'-5' DNA helicase activity, ADP binding, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATPase binding, DNA helicase activity, TBP-class protein binding, TFIID-class transcription factor complex binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, transcription coactivator activity; CC: Ino80 complex, MLL1 complex, NuA4 histone acetyltransferase complex, R2TP complex, RPAP3/R2TP/prefoldin-like complex, Swr1 complex, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, dynein axonemal particle, membrane, nuclear matrix, nuclear speck, nucleoplasm, nucleosome, nucleus, protein folding chaperone complex, protein-containing complex, ribonucleoprotein complex
Pathways: Cell Cycle, Chromosome Maintenance, DNA Damage Recognition in GG-NER, DNA Repair, Deposition of new CENPA-containing nucleosomes at the centromere, Deubiquitination, Formation of the beta-catenin:TCF transactivating complex, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleosome assembly, Nucleotide Excision Repair, Post-translational protein modification, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, UCH proteinases, Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P60122
Entrez ID: 56505
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zbtb8os
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Zbtb8os in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zbtb8os (zinc finger and BTB domain containing 8 opposite strand)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: metal ion binding, molecular_function; CC: tRNA-splicing ligase complex
Pathways:
UniProt: Q505B7
Entrez ID: 67106
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mup16
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mup16 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mup16 (major urinary protein 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: P02762
Entrez ID: 100039177
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dclre1b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dclre1b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dclre1b (DNA cross-link repair 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via nonhomologous end joining, interstrand cross-link repair, nucleotide-excision repair, protection from non-homologous end joining at telomere, telomere capping, telomere maintenance, telomere maintenance via telomere lengthening, telomeric 3' overhang formation, telomeric loop formation; MF: 5'-3' DNA exonuclease activity, 5'-3' exonuclease activity, beta-lactamase activity, damaged DNA binding, exonuclease activity, hydrolase activity, nuclease activity, protein binding, protein homodimerization activity, protein-containing complex binding; CC: centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, nuclear body, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway
UniProt: Q8C7W7
Entrez ID: 140917
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Erh
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Erh in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Erh (ERH mRNA splicing and mitosis factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: methyl-CpG binding; CC: membrane, methylosome, midbody, nucleus
Pathways:
UniProt: P84089
Entrez ID: 13877
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps8
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps8 (ribosomal protein S8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis, translation; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62242
Entrez ID: 20116
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ddx47
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ddx47 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ddx47 (DEAD box helicase 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, apoptotic process, extrinsic apoptotic signaling pathway via death domain receptors, mRNA processing, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CWX9
Entrez ID: 67755
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Myc
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Myc in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Myc (myelocytomatosis oncogene)
Type: protein-coding
Summary: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: B cell apoptotic process, DNA damage response, DNA-templated transcription, DNA-templated transcription initiation, ERK1 and ERK2 cascade, G1/S transition of mitotic cell cycle, MAPK cascade, NK T cell proliferation, Wnt signaling pathway, amino acid transport, branching involved in ureteric bud morphogenesis, cellular response to UV, cellular response to hypoxia, cellular response to interferon-alpha, cellular response to xenobiotic stimulus, chromatin remodeling, chromosome organization, detection of mechanical stimulus involved in sensory perception of sound, glucose metabolic process, inner mitochondrial membrane organization, intracellular iron ion homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, lactic acid secretion, middle ear morphogenesis, myotube differentiation, negative regulation of D-glucose import, negative regulation of cell division, negative regulation of epithelial cell apoptotic process, negative regulation of fibroblast proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of monocyte differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation by RNA polymerase II, pigmentation, positive regulation of ATP biosynthetic process, positive regulation of B cell apoptotic process, positive regulation of DNA-templated transcription, positive regulation of acinar cell proliferation, positive regulation of apoptotic signaling pathway, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of cellular respiration, positive regulation of epithelial cell proliferation, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of glial cell proliferation, positive regulation of glycolytic process, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of mesenchymal cell proliferation, positive regulation of metanephric cap mesenchymal cell proliferation, positive regulation of miRNA transcription, positive regulation of mitochondrial membrane potential, positive regulation of oxidative phosphorylation, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein processing, protein-DNA complex disassembly, pyruvate transport, rRNA metabolic process, re-entry into mitotic cell cycle, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle process, regulation of gene expression, regulation of mitotic cell cycle, regulation of oxidative phosphorylation, regulation of somatic stem cell population maintenance, regulation of telomere maintenance, regulation of transcription by RNA polymerase II, response to alkaloid, response to radiation, response to xenobiotic stimulus, skeletal muscle cell differentiation, skeletal system morphogenesis, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SCF ubiquitin ligase complex binding, cis-regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, double-stranded DNA binding, identical protein binding, protein binding, protein dimerization activity, protein-containing complex binding, sequence-specific DNA binding, transcription coregulator binding, transcription regulator activator activity, ubiquitin protein ligase binding; CC: Myc-Max complex, RNA polymerase II transcription repressor complex, axon, chromatin, chromosome, cytoplasm, euchromatin, nuclear body, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, spindle
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Deubiquitination, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism of proteins, MicroRNAs in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Proteoglycans in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Salmonella infection - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), TFAP2 (AP-2) family regulates transcription of cell cycle factors, TGF-beta signaling pathway - Mus musculus (mouse), Thyroid cancer - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P01108
Entrez ID: 17869
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Kansl3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Kansl3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Kansl3 (KAT8 regulatory NSL complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of mitochondrial transcription; CC: NSL complex, cytoplasm, cytoskeleton, histone acetyltransferase complex, microtubule, mitochondrion, nucleoplasm, nucleus, spindle pole
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: A2RSY1
Entrez ID: 226976
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ogdh
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ogdh in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ogdh (oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2-oxoglutarate decarboxylation to succinyl-CoA, 2-oxoglutarate metabolic process, cerebellar cortex development, generation of precursor metabolites and energy, glycolytic process, hippocampus development, olfactory bulb mitral cell layer development, pyramidal neuron development, striatum development, succinyl-CoA metabolic process, tangential migration from the subventricular zone to the olfactory bulb, thalamus development, tricarboxylic acid cycle; MF: heat shock protein binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, oxoglutarate dehydrogenase (succinyl-transferring) activity, protein-folding chaperone binding, thiamine pyrophosphate binding; CC: cytoplasm, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleus, oxoglutarate dehydrogenase complex
Pathways: 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA, 2-ketoglutarate dehydrogenase complex, Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Glycine degradation, Glyoxylate metabolism and glycine degradation, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Mitochondrial protein degradation, OGDH complex synthesizes succinyl-CoA from 2-OG, lysine degradation II, tryptophan degradation III (eukaryotic)
UniProt: Q60597
Entrez ID: 18293
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ttf1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ttf1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ttf1 (transcription termination factor, RNA polymerase I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription termination, chromatin remodeling, negative regulation of DNA replication, termination of RNA polymerase I transcription, transcription by RNA polymerase I, transcription initiation at RNA polymerase I promoter; MF: DNA binding, chromatin binding, protein binding; CC: fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of proteins, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, Surfactant metabolism, Thyroid hormone synthesis - Mus musculus (mouse)
UniProt: Q62187
Entrez ID: 22130
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nup133
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nup133 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nup133 (nucleoporin 133)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, mRNA export from nucleus, mRNA transport, nephron development, neural tube development, neurogenesis, nuclear pore organization, nucleocytoplasmic transport, paraxial mesoderm development, poly(A)+ mRNA export from nucleus, protein import into nucleus, protein transport, somite development, system development, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; MF: structural constituent of nuclear pore; CC: chromosome, chromosome, centromeric region, kinetochore, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore outer ring, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8R0G9
Entrez ID: 234865
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tbp
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tbp in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tbp (TATA box binding protein)
Type: protein-coding
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within transcription by RNA polymerase II and transcription by RNA polymerase III. Located in cytoplasm and nucleus. Part of RNA polymerase transcription factor SL1 complex and transcription factor TFIID complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and retina. Used to study spinocerebellar ataxia type 17. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase I preinitiation complex assembly, RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, transcription by RNA polymerase II, transcription by RNA polymerase III; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, RNA polymerase III general transcription initiation factor activity, TFIIB-class transcription factor binding, aryl hydrocarbon receptor binding, core promoter sequence-specific DNA binding, enzyme binding, protein binding, transcription cis-regulatory region binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, chromatin, cytoplasm, cytosol, euchromatin, female germ cell nucleus, female pronucleus, male germ cell nucleus, male pronucleus, nucleoplasm, nucleus, pronucleus, protein-containing complex, transcription factor TFIIA complex, transcription factor TFIID complex
Pathways: B-WICH complex positively regulates rRNA expression, Basal transcription factors - Mus musculus (mouse), ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Signaling by Nuclear Receptors, Spinocerebellar ataxia - Mus musculus (mouse), Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse)
UniProt: P29037
Entrez ID: 21374
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl41
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl41 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl41 (ribosomal protein L41)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Orthologous to human RPL41 (ribosomal protein L41). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, translation; MF: mRNA 3'-UTR binding, mRNA 5'-UTR binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, endoplasmic reticulum, ribonucleoprotein complex, ribosome
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosome - Mus musculus (mouse)
UniProt: P62947
Entrez ID: 67945
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dmap1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dmap1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dmap1 (DNA methyltransferase 1-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein import into nucleus, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, response to ethanol; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, transcription corepressor activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus, replication fork
Pathways:
UniProt: Q9JI44
Entrez ID: 66233
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Adnp
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Adnp in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Adnp (activity-dependent neuroprotective protein)
Type: protein-coding
Summary: This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: cGMP-mediated signaling, estrous cycle, intracellular nitric oxide homeostasis, negative regulation of gene expression, negative regulation of neuron apoptotic process, negative regulation of synaptic transmission, neuron differentiation, positive regulation of axon extension, positive regulation of canonical Wnt signaling pathway, positive regulation of neuron projection development, positive regulation of synapse assembly, regulation of gene expression, regulation of transcription by RNA polymerase II, response to carbohydrate, short-term memory; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, beta-catenin binding, beta-tubulin binding, chromatin binding, copper ion binding, metal ion binding, peptide binding, protein binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, axon, chromosome, dendrite, extracellular space, neuronal cell body, nucleus
Pathways:
UniProt: Q9Z103
Entrez ID: 11538
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nob1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nob1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nob1 (NIN1/RPN12 binding protein 1 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA, ribosomal small subunit biogenesis, visual perception; MF: RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, zinc ion binding; CC: cytoplasm, nucleolus, nucleus, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8BW10
Entrez ID: 67619
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ctc1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ctc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ctc1 (CTS telomere maintenance complex component 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, bone marrow development, chromosome organization, hematopoietic stem cell proliferation, multicellular organism growth, negative regulation of telomere maintenance via telomerase, positive regulation of DNA replication, positive regulation of fibroblast proliferation, regulation of G2/M transition of mitotic cell cycle, replicative senescence, spleen development, telomere maintenance, telomere maintenance via telomere lengthening, thymus development; MF: DNA binding, G-rich strand telomeric DNA binding, protein binding, single-stranded DNA binding, telomeric DNA binding; CC: CST complex, chromosome, chromosome, telomeric region, cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: Q5SUQ9
Entrez ID: 68964
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nup54
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nup54 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nup54 (nucleoporin 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, mRNA transport, nuclear pore organization, nucleocytoplasmic transport, protein localization to nuclear inner membrane, protein targeting, protein transport, regulation of protein import into nucleus; MF: identical protein binding, protein-containing complex binding, structural constituent of nuclear pore; CC: membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore central transport channel, nucleus, protein-containing complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8BTS4
Entrez ID: 269113
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rplp0
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
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Does knockout of Rplp0 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
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Gene: Rplp0 (ribosomal protein lateral stalk subunit P0)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-4, cytoplasmic translation, ribosome biogenesis; MF: large ribosomal subunit rRNA binding, peptide binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, dendrite, endoplasmic reticulum, nucleus, postsynapse, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P14869
Entrez ID: 11837
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