screen_file
string | organism
string | perturbation
string | gene
string | cell
string | phenotype
string | hit
int64 | benchmark_type
string | prompt
string | gene_context
string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Uros
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Uros in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Uros (uroporphyrinogen III synthase)
Type: protein-coding
Summary: The protein encoded by this gene is the fourth enzyme in the heme biosynthesis pathway. It converts hydroxymethylbilane to uroporphyrinogen III, a cyclic tetrapyrrole. This enzyme is defective in the autosomal recessive disorder congenital erythropoietic porphyria. Alternate promoter usage controls cell type-specific expression, including erythroid cell-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: cellular response to amine stimulus, cellular response to arsenic-containing substance, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, porphyrin-containing compound biosynthetic process, protoporphyrinogen IX biosynthetic process, response to platinum ion, tetrapyrrole biosynthetic process, uroporphyrinogen III biosynthetic process; MF: folic acid binding, lyase activity, uroporphyrinogen-III synthase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, tetrapyrrole biosynthesis II
UniProt: P51163
Entrez ID: 22276
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl55
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl55 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl55 (mitochondrial ribosomal protein L55)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL55 (mitochondrial ribosomal protein L55). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CZ83
Entrez ID: 67212
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cdc45
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cdc45 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cdc45 (cell division cycle 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, mitotic DNA replication preinitiation complex assembly; MF: DNA replication origin binding, chromatin binding, single-stranded DNA binding; CC: CMG complex, DNA replication preinitiation complex, centrosome, ciliary basal body, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition
UniProt: Q9Z1X9
Entrez ID: 12544
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Setdb1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Setdb1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Setdb1 (SET domain, bifurcated 1)
Type: protein-coding
Summary: Enables DNA binding activity; histone H3K9 methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation-dependent constitutive heterochromatin formation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and transposable element silencing by heterochromatin formation. Acts upstream of or within bone development; inner cell mass cell proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1-cell stage embryo; central nervous system; heart; long bone; and oocyte. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, bone development, chromatin organization, heterochromatin organization, inner cell mass cell proliferation, methylation, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of transcription by RNA polymerase II, transposable element silencing by heterochromatin formation; MF: DNA binding, chromatin binding, histone H3K9 dimethyltransferase activity, histone H3K9 methyltransferase activity, histone H3K9 monomethyltransferase activity, histone H3K9 trimethyltransferase activity, histone H3K9me2 methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, promoter-specific chromatin binding, protein binding, transferase activity, zinc ion binding; CC: chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Lysine degradation - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: G5E8N3, D3YYC3
Entrez ID: 84505
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Memo1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Memo1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Memo1 (mediator of cell motility 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of microtubule-based process
Pathways: ERBB2 Regulates Cell Motility, Signal Transduction, Signaling by ERBB2, Signaling by Receptor Tyrosine Kinases
UniProt: Q91VH6
Entrez ID: 76890
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cpox
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cpox in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cpox (coproporphyrinogen oxidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment or maintenance of transmembrane electrochemical gradient, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, porphyrin-containing compound biosynthetic process, potassium ion transport, protoporphyrinogen IX biosynthetic process, response to arsenic-containing substance, response to insecticide, response to iron ion, response to lead ion, response to methylmercury, sodium ion transport; MF: P-type sodium:potassium-exchanging transporter activity, coproporphyrinogen oxidase activity, identical protein binding, oxidoreductase activity, protein homodimerization activity, structural constituent of eye lens; CC: cytoplasm, cytosol, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion
Pathways: Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, heme biosynthesis from uroporphyrinogen-III I
UniProt: P36552
Entrez ID: 12892
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl28
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl28 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl28 (ribosomal protein L28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cell body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, dendrite, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P41105
Entrez ID: 19943
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Atic
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Atic in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Atic (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase)
Type: protein-coding
Summary: Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Acts upstream of or within cellular response to interleukin-7. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, animal organ regeneration, brainstem development, cellular response to interleukin-7, cerebellum development, cerebral cortex development, dihydrofolate metabolic process, purine nucleotide biosynthetic process, tetrahydrofolate biosynthetic process; MF: IMP cyclohydrolase activity, catalytic activity, hydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion, plasma membrane
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, One carbon pool by folate - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, inosine-5,-phosphate biosynthesis II
UniProt: Q9CWJ9
Entrez ID: 108147
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pdcd11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pdcd11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pdcd11 (programmed cell death 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, rRNA processing; MF: NF-kappaB binding, RNA binding, nucleic acid binding; CC: cytosol, nucleolus, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6NS46
Entrez ID: 18572
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Uqcr10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Uqcr10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Uqcr10 (ubiquinol-cytochrome c reductase, complex III subunit X)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q8R1I1
Entrez ID: 66152
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rcc1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rcc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rcc1 (regulator of chromosome condensation 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, chromosome segregation, mitotic spindle organization, regulation of mitotic cell cycle, regulation of mitotic nuclear division, regulation of mitotic spindle assembly, spindle assembly; MF: DNA binding, chromatin binding, guanyl-nucleotide exchange factor activity, histone binding, nucleosomal DNA binding, nucleosome binding, protein heterodimerization activity, small GTPase binding, sulfate binding; CC: chromatin, chromosome, condensed nuclear chromosome, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Nuclear Envelope (NE) Reassembly, Postmitotic nuclear pore complex (NPC) reformation
UniProt: Q8VE37
Entrez ID: 100088
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Exosc1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Exosc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Exosc1 (exosome component 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, RNA processing, rRNA processing; MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DAA6
Entrez ID: 66583
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Smc5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Smc5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Smc5 (structural maintenance of chromosomes 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell division, cellular senescence, chromosome condensation, chromosome organization, chromosome segregation, double-strand break repair via homologous recombination, host-mediated suppression of viral genome replication, mitotic cell cycle phase transition, positive regulation of chromosome segregation, positive regulation of maintenance of mitotic sister chromatid cohesion, protein localization to chromosome, centromeric region, stem cell population maintenance, telomere maintenance via recombination; MF: ATP binding, DNA secondary structure binding, molecular_function, nucleotide binding, single-stranded DNA binding; CC: PML body, Smc5-Smc6 complex, cell junction, chromosome, chromosome, centromeric region, chromosome, telomeric region, cytoplasm, interchromatin granule, nuclear speck, nucleus, sex chromosome, site of double-strand break
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q8CG46
Entrez ID: 226026
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Grwd1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Grwd1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Grwd1 (glutamate-rich WD repeat containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, nucleosome assembly, nucleosome disassembly, ribosome biogenesis; MF: DNA replication origin binding, chromatin binding, histone binding; CC: chromosome, cytosol, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q810D6
Entrez ID: 101612
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Parn
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Parn in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Parn (poly(A)-specific ribonuclease (deadenylation nuclease))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, box H/ACA sno(s)RNA 3'-end processing, lncRNA processing, mRNA catabolic process, miRNA catabolic process, negative regulation of macromolecule metabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA poly(A) tail shortening, poly(A)-dependent snoRNA 3'-end processing, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of telomere maintenance via telomerase, priRNA 3'-end processing, regulation of RNA stability, regulation of telomerase RNA localization to Cajal body, siRNA 3'-end processing, telomerase RNA stabilization; MF: 3'-5'-RNA exonuclease activity, RNA binding, cation binding, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, poly(A)-specific ribonuclease activity, protein binding, protein kinase binding, telomerase RNA binding; CC: cytoplasm, glutamatergic synapse, nuclear speck, nucleolus, nucleus, postsynapse
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Metabolism of RNA, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements
UniProt: Q8VDG3
Entrez ID: 74108
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Bms1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Bms1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Bms1 (BMS1, ribosome biogenesis factor)
Type: protein-coding
Summary: Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in chromosome; nucleolus; and nucleoplasm. Predicted to be part of small-subunit processome. Human ortholog(s) of this gene implicated in nonsyndromic aplasia cutis congenita. Orthologous to human BMS1 (BMS1 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit biogenesis, ribosome biogenesis; MF: ATP binding, GTP binding, GTPase activity, U3 snoRNA binding, hydrolase activity, nucleotide binding; CC: chromosome, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6PGF5
Entrez ID: 213895
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Trim28
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Trim28 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Trim28 (tripartite motif-containing 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, DNA repair, chromatin organization, convergent extension involved in axis elongation, embryo implantation, embryonic placenta morphogenesis, epigenetic programming of gene expression, epithelial to mesenchymal transition, genomic imprinting, in utero embryonic development, innate immune response, negative regulation of DNA-templated transcription, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein import into nucleus, proteasome-mediated ubiquitin-dependent protein catabolic process, protein sumoylation, suppression of viral release by host; MF: DNA binding, Krueppel-associated box domain binding, SUMO ligase activity, SUMO transferase activity, chromatin binding, chromo shadow domain binding, metal ion binding, promoter-specific chromatin binding, protein binding, protein kinase activity, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-like protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: RNA polymerase II transcription regulator complex, chromatin, euchromatin, heterochromatin, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q62318
Entrez ID: 21849
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpn1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpn1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpn1 (ribophorin I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B, rough endoplasmic reticulum
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, N-Glycan biosynthesis - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q91YQ5
Entrez ID: 103963
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dbr1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dbr1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dbr1 (debranching RNA lariats 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA fragment catabolic process, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome; MF: RNA lariat debranching enzyme activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q923B1
Entrez ID: 83703
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Opa1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Opa1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Opa1 (OPA1, mitochondrial dynamin like GTPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GTP metabolic process, apoptotic process, calcium import into the mitochondrion, cellular senescence, cristae formation, inner mitochondrial membrane organization, intracellular distribution of mitochondria, membrane fusion, membrane tubulation, mitochondrial fusion, mitochondrial inner membrane fusion, mitochondrion organization, negative regulation of apoptotic process, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of release of cytochrome c from mitochondria, neural tube closure, peroxisome fission, positive regulation of T-helper 17 cell lineage commitment, positive regulation of cellular response to insulin stimulus, positive regulation of dendrite development, positive regulation of dendritic spine morphogenesis, positive regulation of insulin receptor signaling pathway, positive regulation of interleukin-17 production, positive regulation of mitochondrial fusion, positive regulation of neuron maturation, protein complex oligomerization, regulation of mitochondrion organization, visual perception; MF: GTP binding, GTPase activity, GTPase-dependent fusogenic activity, cardiolipin binding, hydrolase activity, kinase binding, lipid binding, membrane bending activity, metal ion binding, microtubule binding, nucleotide binding, phosphatidic acid binding, protein binding, protein-containing complex binding; CC: cytoplasm, cytosol, dendrite, membrane, microtubule, mitochondrial crista, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, nucleoplasm
Pathways: Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: P58281
Entrez ID: 74143
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rbbp4
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rbbp4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rbbp4 (retinoblastoma binding protein 4, chromatin remodeling factor)
Type: protein-coding
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in DNA replication-dependent chromatin assembly; chromatin remodeling; and regulation of DNA-templated transcription. Located in nucleus. Part of ESC/E(Z) complex and NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; gonad; hemolymphoid system gland; and retina nuclear layer. Orthologous to human RBBP4 (RB binding protein 4, chromatin remodeling factor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin assembly, brain development, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, nucleosome assembly, positive regulation of DNA-templated transcription, positive regulation of stem cell population maintenance, regulation of DNA-templated transcription, regulation of cell fate specification, regulation of stem cell differentiation; MF: ATP-dependent activity, acting on DNA, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone binding, histone deacetylase binding, protein binding; CC: ATPase complex, CAF-1 complex, ESC/E(Z) complex, NURF complex, NuRD complex, Sin3-type complex, chromatin, chromosome, chromosome, telomeric region, cytosol, histone deacetylase complex, nucleoplasm, nucleus, protein-containing complex
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell Cycle, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Chromatin modifying enzymes, Chromatin organization, Chromosome Maintenance, Co-inhibition by PD-1, Deposition of new CENPA-containing nucleosomes at the centromere, Epigenetic regulation of gene expression, G0 and Early G1, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Immune System, Intracellular signaling by second messengers, Mitotic G1 phase and G1/S transition, Negative Regulation of CDH1 Gene Transcription, Nucleosome assembly, Oxidative Stress Induced Senescence, PIP3 activates AKT signaling, PKMTs methylate histone lysines, PRC2 methylates histones and DNA, PTEN Regulation, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of PTEN gene transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Signal Transduction, Transcriptional Regulation by E2F6, Transcriptional Regulation by TP53
UniProt: Q60972
Entrez ID: 19646
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Aldoa
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Aldoa in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Aldoa (aldolase A, fructose-bisphosphate)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP biosynthetic process, binding of sperm to zona pellucida, canonical glycolysis, fructose 1,6-bisphosphate metabolic process, fructose metabolic process, glycolytic process, glycolytic process through fructose-6-phosphate, hexose metabolic process, methylglyoxal biosynthetic process, muscle cell cellular homeostasis, positive regulation of cell migration, protein homotetramerization, regulation of cell shape, striated muscle contraction; MF: cytoskeletal protein binding, fructose binding, fructose-bisphosphate aldolase activity, identical protein binding, lyase activity, protease binding; CC: I band, M band, Z disc, actin cytoskeleton, cytoplasm, cytosol, extracellular exosome, extracellular space, heterochromatin, membrane, myelin sheath, plasma membrane, protein-containing complex, sperm fibrous sheath, sperm head
Pathways: Fructose and mannose metabolism - Mus musculus (mouse), Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Pentose phosphate pathway - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, gluconeogenesis I, glycolysis I, glycolysis III, glycolysis V (Pyrococcus), sucrose degradation V (mammalian)
UniProt: P05064
Entrez ID: 11674
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dnaaf5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dnaaf5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dnaaf5 (dynein, axonemal assembly factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium movement, inner dynein arm assembly, outer dynein arm assembly; MF: dynein intermediate chain binding; CC: cytoplasm, cytosol, dynein axonemal particle, microtubule cytoskeleton, mitotic spindle, motile cilium, nucleolus
Pathways:
UniProt: B9EJR8
Entrez ID: 433956
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dkc1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dkc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dkc1 (dyskeratosis congenita 1, dyskerin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA modification, RNA processing, box H/ACA sno(s)RNA 3'-end processing, box H/ACA sno(s)RNA metabolic process, enzyme-directed rRNA pseudouridine synthesis, mRNA pseudouridine synthesis, positive regulation of cell population proliferation, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, pseudouridine synthesis, rRNA processing, rRNA pseudouridine synthesis, regulation of telomerase RNA localization to Cajal body, ribosome biogenesis, scaRNA localization to Cajal body, snRNA pseudouridine synthesis, snoRNA guided rRNA pseudouridine synthesis, telomerase RNA stabilization, telomerase holoenzyme complex assembly, telomere maintenance via telomerase; MF: RNA binding, box H/ACA snoRNA binding, isomerase activity, protein binding, pseudouridine synthase activity, telomerase RNA binding, telomerase activity; CC: Cajal body, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, fibrillar center, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q9ESX5
Entrez ID: 245474
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gatad2a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gatad2a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gatad2a (GATA zinc finger domain containing 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior neuropore closure, blood vessel development, chromatin remodeling, embryonic body morphogenesis, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, neural fold formation, positive regulation of DNA-templated transcription, programmed cell death, regulation of cell fate specification, regulation of stem cell differentiation; MF: metal ion binding, protein-macromolecule adaptor activity, zinc ion binding; CC: NuRD complex, chromosome, nuclear speck, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Signal Transduction, Transcriptional Regulation by TP53
UniProt: Q8CHY6
Entrez ID: 234366
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Paf1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Paf1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Paf1 (Paf1, RNA polymerase II complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, cellular response to lipopolysaccharide, endodermal cell fate commitment, mRNA 3'-end processing, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of cell cycle G1/S phase transition, positive regulation of transcription by RNA polymerase II, protein localization to nucleus, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, chromatin binding, protein binding; CC: Cdc73/Paf1 complex, cytoplasm, fibrillar center, membrane, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q8K2T8
Entrez ID: 54624
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Prmt5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Prmt5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Prmt5 (protein arginine N-methyltransferase 5)
Type: protein-coding
Summary: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: DNA-templated transcription termination, Golgi ribbon formation, chromatin organization, chromatin remodeling, circadian regulation of gene expression, endothelial cell activation, gene expression, methylation, negative regulation of cell differentiation, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, peptidyl-arginine methylation, positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway, positive regulation of mRNA splicing, via spliceosome, positive regulation of oligodendrocyte differentiation, regulation of DNA-templated transcription, regulation of ERK1 and ERK2 cascade, regulation of gene expression, rhythmic process, spliceosomal snRNP assembly; MF: E-box binding, chromatin binding, histone H2AR3 methyltransferase activity, histone H4R3 methyltransferase activity, histone arginine N-methyltransferase activity, identical protein binding, methyl-CpG binding, methyltransferase activity, p53 binding, protein binding, protein heterodimerization activity, protein-arginine N-methyltransferase activity, protein-arginine omega-N symmetric methyltransferase activity, protein-containing complex binding, ribonucleoprotein complex binding, transcription corepressor activity, transferase activity; CC: Golgi apparatus, chromatin, cytoplasm, cytosol, histone methyltransferase complex, male germ cell nucleus, methylosome, nucleoplasm, nucleus, protein-containing complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, Metabolism of non-coding RNA, RMTs methylate histone arginines, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Transcriptional Regulation by TP53, snRNP Assembly
UniProt: Q8CIG8
Entrez ID: 27374
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ddx19a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ddx19a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ddx19a (DEAD box helicase 19a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: poly(A)+ mRNA export from nucleus, positive regulation of apoptotic process, response to zinc ion; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding; CC: cytoplasm, cytoplasmic stress granule, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q61655
Entrez ID: 13680
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tuba1a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tuba1a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tuba1a (tubulin, alpha 1A)
Type: protein-coding
Summary: Enables GTP binding activity and protein heterodimerization activity. Involved in several processes, including learning or memory; microtubule cytoskeleton organization; and nervous system development. Located in cytoplasmic microtubule. Is active in several cellular components, including condensed chromosome; neuromuscular junction; and sperm flagellum. Is expressed in several structures, including 4-cell stage embryo; brain; hemolymphoid system gland; musculature; and testis. Used to study congenital nervous system abnormality and lissencephaly. Human ortholog(s) of this gene implicated in lissencephaly; lissencephaly 3; and microcephaly. Orthologous to human TUBA1A (tubulin alpha 1a). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: adult behavior, adult locomotory behavior, cellular response to calcium ion, centrosome cycle, cerebellar cortex morphogenesis, cerebral cortex development, dentate gyrus development, flagellated sperm motility, forebrain morphogenesis, gene expression, glial cell differentiation, hippocampus development, homeostasis of number of cells within a tissue, intracellular protein transport, locomotory behavior, locomotory exploration behavior, memory, microtubule cytoskeleton organization, microtubule polymerization, microtubule-based process, mitotic cell cycle, motor behavior, neurogenesis, neuron apoptotic process, neuron differentiation, neuron migration, neuron projection arborization, organelle transport along microtubule, pyramidal neuron differentiation, regulation of synapse organization, response to L-glutamate, response to mechanical stimulus, response to tumor necrosis factor, smoothened signaling pathway, startle response, synapse organization, visual learning; MF: GTP binding, hydrolase activity, identical protein binding, metal ion binding, nucleotide binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein-containing complex binding, structural constituent of cytoskeleton; CC: axonemal microtubule, cell projection, cilium, condensed chromosome, cytoplasm, cytoplasmic microtubule, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, membrane raft, microtubule, microtubule cytoskeleton, motile cilium, myelin sheath, neuromuscular junction, plasma membrane, recycling endosome, sperm flagellum, synapse
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Aggrephagy, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Antiviral mechanism by IFN-stimulated genes, Apoptosis - Mus musculus (mouse), Asparagine N-linked glycosylation, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, Cytokine Signaling in Immune system, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, G2/M Transition, Gap junction - Mus musculus (mouse), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Mus musculus (mouse), Immune System, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Recycling pathway of L1, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Salmonella infection - Mus musculus (mouse), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Mus musculus (mouse), Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P68369
Entrez ID: 22142
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Lars2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Lars2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Lars2 (leucyl-tRNA synthetase, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aminoacyl-tRNA metabolism involved in translational fidelity, leucyl-tRNA aminoacylation, mitochondrial translation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA deacylase activity, aminoacyl-tRNA ligase activity, leucine-tRNA ligase activity, ligase activity, nucleotide binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8VDC0
Entrez ID: 102436
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pgd
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pgd in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pgd (phosphogluconate dehydrogenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: D-gluconate metabolic process, NADP+ metabolic process, NADPH regeneration, pentose biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch; MF: NADP binding, carbohydrate binding, carboxylic acid binding, oxidoreductase activity, phosphogluconate dehydrogenase (decarboxylating) activity; CC: cytoplasm, cytosol
Pathways: Glutathione metabolism - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), pentose phosphate pathway, pentose phosphate pathway (oxidative branch)
UniProt: Q9DCD0
Entrez ID: 110208
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Matr3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Matr3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Matr3 (matrin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, blastocyst formation, heart valve development, immune system process, innate immune response, post-transcriptional regulation of gene expression, ventricular septum development; MF: RNA binding, identical protein binding, metal ion binding, miRNA binding, nucleic acid binding, zinc ion binding; CC: nuclear matrix, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse)
UniProt: Q8K310
Entrez ID: 17184
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif3m
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif3m in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif3m (eukaryotic translation initiation factor 3, subunit M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation; MF: translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q99JX4
Entrez ID: 98221
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hmbs
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Hmbs in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hmbs (hydroxymethylbilane synthase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, liver development, porphyrin-containing compound biosynthetic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process, response to xenobiotic stimulus, tetrapyrrole biosynthetic process; MF: amine binding, carboxylic acid binding, hydroxymethylbilane synthase activity, transferase activity, uroporphyrinogen-III synthase activity; CC: axon, condensed chromosome, cytoplasm, cytosol, perinuclear region of cytoplasm
Pathways: Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, tetrapyrrole biosynthesis II
UniProt: P22907
Entrez ID: 15288
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hsp90ab1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Hsp90ab1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hsp90ab1 (heat shock protein 90 alpha (cytosolic), class B member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to heat, cellular response to interleukin-4, chaperone-mediated protein complex assembly, negative regulation of apoptotic process, negative regulation of complement-dependent cytotoxicity, negative regulation of neuron apoptotic process, negative regulation of proteasomal protein catabolic process, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, placenta development, positive regulation of cell differentiation, positive regulation of cell size, positive regulation of nitric oxide biosynthetic process, positive regulation of protein import into nucleus, positive regulation of protein localization to cell surface, positive regulation of transforming growth factor beta receptor signaling pathway, protein folding, protein stabilization, regulation of cell cycle, regulation of protein localization, regulation of protein ubiquitination, supramolecular fiber organization, telomerase holoenzyme complex assembly, telomere maintenance via telomerase, virion attachment to host cell; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein binding, ATP-dependent protein folding chaperone, CTP binding, DNA polymerase binding, GTP binding, TPR domain binding, UTP binding, dATP binding, disordered domain specific binding, double-stranded RNA binding, heat shock protein binding, heterocyclic compound binding, histone deacetylase binding, histone methyltransferase binding, identical protein binding, kinase binding, nitric-oxide synthase regulator activity, nucleotide binding, peptide binding, protein binding, protein dimerization activity, protein folding chaperone, protein homodimerization activity, protein kinase binding, protein kinase regulator activity, protein phosphatase activator activity, receptor ligand inhibitor activity, sulfonylurea receptor binding, tau protein binding, transmembrane transporter binding, ubiquitin protein ligase binding, unfolded protein binding; CC: COP9 signalosome, HSP90-CDC37 chaperone complex, apical plasma membrane, aryl hydrocarbon receptor complex, axonal growth cone, basolateral plasma membrane, brush border membrane, cell surface, cytoplasm, cytosol, dendritic growth cone, dynein axonemal particle, extracellular region, inclusion body, lysosomal membrane, melanosome, membrane, mitochondrion, neuronal cell body, nucleus, ooplasm, perinuclear region of cytoplasm, plasma membrane, protein folding chaperone complex, protein-containing complex, sperm head plasma membrane
Pathways: Antigen processing and presentation - Mus musculus (mouse), Aryl hydrocarbon receptor signalling, Attenuation phase, Axon guidance, Biological oxidations, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), DDX58/IFIH1-mediated induction of interferon-alpha/beta, Developmental Biology, ESR-mediated signaling, Estrogen signaling pathway - Mus musculus (mouse), Estrogen-dependent gene expression, Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), G2/M Transition, HSF1 activation, HSF1-dependent transactivation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammasomes, Innate Immune System, Lipid and atherosclerosis - Mus musculus (mouse), Metabolism, Mitotic G2-G2/M phases, NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Nervous system development, Neutrophil degranulation, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phase I - Functionalization of compounds, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Sema3A PAK dependent Axon repulsion, Semaphorin interactions, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Th17 cell differentiation - Mus musculus (mouse), The NLRP3 inflammasome, The role of GTSE1 in G2/M progression after G2 checkpoint
UniProt: P11499
Entrez ID: 15516
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mars2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mars2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mars2 (methionine-tRNA synthetase 2 (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methionyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, methionine-tRNA ligase activity, nucleotide binding; CC: mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), Selenocompound metabolism - Mus musculus (mouse), tRNA charging pathway
UniProt: Q499X9
Entrez ID: 212679
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tmem70
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tmem70 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tmem70 (transmembrane protein 70)
Type: protein-coding
Summary: Predicted to enable mitochondrial proton-transporting ATP synthase complex binding activity. Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrion. Is expressed in several structures, including brain; gut; nasal cavity epithelium; orbito-sphenoid; and urinary system. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 2. Orthologous to human TMEM70 (transmembrane protein 70). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial proton-transporting ATP synthase complex assembly, mitochondrial respiratory chain complex I assembly, protein complex oligomerization, protein homooligomerization; MF: mitochondrial proton-transporting ATP synthase complex binding; CC: membrane, mitochondrial crista, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways:
UniProt: Q921N7
Entrez ID: 70397
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl23a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl23a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl23a (ribosomal protein L23A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, TORC2 complex binding, large ribosomal subunit rRNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62751
Entrez ID: 268449
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cox17
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cox17 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cox17 (cytochrome c oxidase assembly protein 17, copper chaperone)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: heart development, mitochondrial cytochrome c oxidase assembly, positive regulation of cell population proliferation; MF: copper chaperone activity, copper ion binding, cuprous ion binding, enzyme activator activity, metal ion binding; CC: cytoplasm, mitochondrial intermembrane space, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Oxidative phosphorylation - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: P56394
Entrez ID: 12856
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mbtps1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mbtps1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mbtps1 (membrane-bound transcription factor peptidase, site 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, cholesterol metabolic process, lipid metabolic process, lysosome organization, membrane protein intracellular domain proteolysis, mitotic G2 DNA damage checkpoint signaling, positive regulation of cholesterol biosynthetic process, protein import into nucleus, protein maturation, protein processing, proteolysis, regulation of vesicle-mediated transport, steroid metabolic process; MF: endopeptidase activity, hydrolase activity, metalloendopeptidase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: Golgi apparatus, Golgi membrane, Golgi stack, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: ATF6 (ATF6-alpha) activates chaperones, ATF6B (ATF6-beta) activates chaperones, CREB3 factors activate genes, Cellular responses to stimuli, Cellular responses to stress, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Post-translational protein modification, Post-translational protein phosphorylation, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Regulation of cholesterol biosynthesis by SREBP (SREBF), Unfolded Protein Response (UPR)
UniProt: Q9WTZ2
Entrez ID: 56453
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Top1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Top1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Top1 (topoisomerase (DNA) I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA topological change, animal organ regeneration, cellular response to luteinizing hormone stimulus, chromatin remodeling, chromosome segregation, circadian regulation of gene expression, circadian rhythm, embryonic cleavage, rRNA transcription, response to cAMP, response to gamma radiation, response to temperature stimulus, response to xenobiotic stimulus, rhythmic process; MF: ATP binding, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, isomerase activity, protein domain specific binding, protein serine/threonine kinase activity, protein-containing complex binding, single-stranded DNA binding, supercoiled DNA binding; CC: P-body, chromosome, cytoplasm, dense fibrillar component, fibrillar center, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, perikaryon, protein-DNA complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: Q04750
Entrez ID: 21969
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tefm
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tefm in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tefm (transcription elongation factor, mitochondrial)
Type: protein-coding
Summary: Predicted to enable DNA polymerase processivity factor activity and transcription elongation factor activity. Predicted to be involved in mitochondrial transcription; oxidative phosphorylation; and positive regulation of mitochondrial transcription. Predicted to be located in mitochondrial matrix. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human TEFM (transcription elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: positive regulation of mitochondrial transcription, regulation of oxidative phosphorylation, transcription elongation by mitochondrial RNA polymerase; MF: nucleic acid binding, transcription elongation factor activity; CC: mitochondrial matrix, mitochondrial nucleoid, mitochondrion, ribonucleoprotein complex
Pathways:
UniProt: Q5SSK3
Entrez ID: 68550
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Txnrd1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Txnrd1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Txnrd1 (thioredoxin reductase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, May 2017].
Gene Ontology: BP: benzene-containing compound metabolic process, cell population proliferation, cell redox homeostasis, cellular oxidant detoxification, gastrulation, hydrogen peroxide catabolic process, mesoderm formation, positive regulation of apoptotic process, response to oxidative stress, selenocysteine metabolic process; MF: FAD binding, NAD(P)H oxidase H2O2-forming activity, NADPH peroxidase activity, flavin adenine dinucleotide binding, identical protein binding, mercury ion binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor, selenate reductase activity, thioredoxin-disulfide reductase (NADPH) activity; CC: cytoplasm, cytosol, fibrillar center, mitochondrion, neuronal cell body, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Gene expression (Transcription), Generic Transcription Pathway, Hepatocellular carcinoma - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested MeSeO2H into MeSeH, Metabolism of nucleotides, Pathways in cancer - Mus musculus (mouse), RNA Polymerase II Transcription, Selenoamino acid metabolism, Selenocompound metabolism - Mus musculus (mouse), TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, thioredoxin pathway
UniProt: Q9JMH6
Entrez ID: 50493
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Esf1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Esf1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Esf1 (ESF1 nucleolar pre-rRNA processing protein homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q3V1V3
Entrez ID: 66580
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Krr1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Krr1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Krr1 (KRR1, small subunit (SSU) processome component, homolog (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, nucleic acid binding; CC: chromosome, intercellular bridge, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8BGA5
Entrez ID: 52705
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eef2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eef2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eef2 (eukaryotic translation elongation factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to brain-derived neurotrophic factor stimulus, glial cell proliferation, hematopoietic progenitor cell differentiation, positive regulation of cytoplasmic translation, positive regulation of translation, response to endoplasmic reticulum stress, response to estradiol, response to ethanol, response to folic acid, response to hydrogen peroxide, response to ischemia, response to xenobiotic stimulus, skeletal muscle cell differentiation, skeletal muscle contraction, translation, translation at postsynapse, translational elongation; MF: 5S rRNA binding, GTP binding, GTPase activity, RNA binding, actin filament binding, hydrolase activity, lncRNA binding, nucleotide binding, p53 binding, protein binding, protein kinase binding, ribosome binding, translation elongation factor activity; CC: aggresome, cytoplasm, cytosol, glutamatergic synapse, nucleus, plasma membrane, postsynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Eukaryotic Translation Elongation, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Oxytocin signaling pathway - Mus musculus (mouse), Peptide chain elongation, Post-translational protein modification, Protein methylation, Synthesis of diphthamide-EEF2, Translation
UniProt: P58252
Entrez ID: 13629
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mios
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mios in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mios (meiosis regulator for oocyte development)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to amino acid starvation, cellular response to nutrient levels, central nervous system myelin formation, oligodendrocyte differentiation, oligodendrocyte progenitor proliferation, positive regulation of TORC1 signaling, protein-containing complex localization; MF: metal ion binding, molecular_function, zinc ion binding; CC: GATOR2 complex, cell junction, cytoplasm, cytosol, lysosomal membrane, lysosome, membrane, nucleoplasm
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8VE19
Entrez ID: 252875
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Urm1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Urm1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Urm1 (ubiquitin related modifier 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble uridine modification; MF: protein tag activity, sulfur carrier activity; CC: cytoplasm, cytosol, nucleus
Pathways: Sulfur relay system - Mus musculus (mouse)
UniProt: Q9D2P4
Entrez ID: 68205
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hmgcs1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Hmgcs1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hmgcs1 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA metabolic process, cellular response to low-density lipoprotein particle stimulus, cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, farnesyl diphosphate biosynthetic process, mevalonate pathway, isopentenyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid metabolic process, response to purine-containing compound, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: acyltransferase activity, hydroxymethylglutaryl-CoA synthase activity, isomerase activity, organic acid binding, protein homodimerization activity, small molecule binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Butanoate metabolism - Mus musculus (mouse), Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, PPAR signaling pathway - Mus musculus (mouse), Terpenoid backbone biosynthesis - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), ketogenesis, mevalonate pathway I, superpathway of cholesterol biosynthesis
UniProt: Q8JZK9
Entrez ID: 208715
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cebpz
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cebpz in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cebpz (CCAAT/enhancer binding protein zeta)
Type: protein-coding
Summary: Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of CCAAT-binding activity factor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; bone; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: CC: CCAAT-binding factor complex, nucleoplasm, nucleus
Pathways:
UniProt: P53569
Entrez ID: 12607
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Lamtor1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Lamtor1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Lamtor1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, autophagosome assembly, cellular response to amino acid stimulus, cellular response to nutrient levels, cholesterol homeostasis, cytoplasmic translation, endosomal transport, endosome organization, intracellular protein localization, lysosome localization, lysosome organization, negative regulation of autophagy, negative regulation of translational initiation, positive regulation of MAPK cascade, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of protein localization to lysosome, positive regulation of translational initiation, protein localization to lysosome, protein localization to membrane, regulation of cell growth, regulation of cholesterol efflux, regulation of cholesterol import, regulation of receptor recycling; MF: GTPase binding, guanyl-nucleotide exchange factor activity, molecular adaptor activity, protein binding, protein-membrane adaptor activity; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, membrane raft
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, Neutrophil degranulation, PIP3 activates AKT signaling, PTEN Regulation, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, RHOQ GTPase cycle, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q9CQ22
Entrez ID: 66508
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Psmc6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Psmc6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Psmc6 (proteasome (prosome, macropain) 26S subunit, ATPase, 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, positive regulation of RNA polymerase II transcription preinitiation complex assembly, positive regulation of inclusion body assembly, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, identical protein binding, nucleotide binding, proteasome-activating activity; CC: cytoplasm, cytosolic proteasome complex, inclusion body, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Epstein-Barr virus infection - Mus musculus (mouse), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P62334
Entrez ID: 67089
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Vrk1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Vrk1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Vrk1 (vaccinia related kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Cajal body organization, DNA damage response, Golgi disassembly, cell division, chromatin remodeling, neuron projection development, positive regulation of protein localization to chromatin, positive regulation of transcription by RNA polymerase II, regulation of neuron migration, signal transduction; MF: ATP binding, histone H2AX kinase activity, histone H3S10 kinase activity, histone H3T3 kinase activity, histone binding, kinase activity, nucleosomal DNA binding, nucleotide binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Cajal body, Golgi stack, chromatin, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown
UniProt: Q80X41
Entrez ID: 22367
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nelfb
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nelfb in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nelfb (negative elongation factor complex member B)
Type: protein-coding
Summary: This gene encodes subunit B of a metazoan-specific, four-subunit protein complex that regulates promoter-proximal pausing of RNA polymerase II. RNA polymerase II pausing is thought to be important for coordination of gene transcription during embryonic development and stress responses. Consistently, disruption of this gene in mouse causes inner cell mass deficiency and embryonic lethality. In addition, this gene is required for maintenance of mouse embryonic stem cells by preventing expression of developmental genes. In adult mice, conditional deletion of this gene results in cardiomyopathy and impaired response to cardiac stress. Multiple protein isoforms are encoded through the use of a non-AUG (CUG) initiation codon and an alternative downstream AUG initiation codon. In addition, alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: cell population proliferation, negative regulation of DNA-templated transcription, negative regulation of stem cell differentiation, negative regulation of transcription elongation by RNA polymerase II, stem cell differentiation; MF: RNA binding, protein binding; CC: NELF complex, cytoplasm, cytosol, mitochondrial outer membrane, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q8C4Y3
Entrez ID: 58202
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rae1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rae1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rae1 (ribonucleic acid export 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, cell division, nucleocytoplasmic transport, regulation of mitotic spindle organization, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; MF: RNA binding, ubiquitin binding; CC: cytoplasm, cytoskeleton, fibrillar center, mitotic spindle pole, nuclear envelope, nuclear pore, nucleoplasm, nucleus, spindle pole
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Influenza A - Mus musculus (mouse), Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q8C570
Entrez ID: 66679
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Polrmt
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Polrmt in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Polrmt (polymerase (RNA) mitochondrial (DNA directed))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, mitochondrial transcription, transcription initiation at mitochondrial promoter; MF: 3'-5'-RNA exonuclease activity, 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, mitochondrial promoter sequence-specific DNA binding, nucleotidyltransferase activity, protein binding, sequence-specific DNA binding, transferase activity; CC: DNA-directed RNA polymerase complex, mitochondrial DNA-directed RNA polymerase complex, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, protein-containing complex
Pathways: DNA Replication, Gene expression (Transcription), Mitochondrial transcription initiation, Strand-asynchronous mitochondrial DNA replication, Transcription from mitochondrial promoters
UniProt: Q8BKF1
Entrez ID: 216151
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Wdr33
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Wdr33 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Wdr33 (WD repeat domain 33)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing, mRNA processing; CC: collagen trimer, fibrillar center, mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8K4P0
Entrez ID: 74320
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nop16
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nop16 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nop16 (NOP16 nucleolar protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9CPT5
Entrez ID: 28126
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Vps33a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Vps33a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Vps33a (VPS33A CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, endosome to lysosome transport, intracellular protein transport, lysosome localization, melanosome localization, pigmentation, platelet formation, protein transport, regulation of developmental pigmentation, regulation of lysosomal lumen pH, vesicle-mediated transport; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, autophagosome, clathrin complex, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm
Pathways: Salmonella infection - Mus musculus (mouse)
UniProt: Q9D2N9
Entrez ID: 77573
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mak16
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mak16 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mak16 (MAK16 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA; CC: nucleolus, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q8BGS0
Entrez ID: 67920
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl31
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl31 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl31 (ribosomal protein L31)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in early conceptus and embryo. Orthologous to human RPL31 (ribosomal protein L31). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, translation; MF: protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, nucleoplasm, postsynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62900
Entrez ID: 114641
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ybey
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ybey in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ybey (ybeY metallopeptidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, nuclease activity; CC: mitochondrion, nucleus
Pathways:
UniProt: Q8CAV0
Entrez ID: 216119
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pop5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pop5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pop5 (processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae))
Type: protein-coding
Summary: Enables ribonuclease P activity. Acts upstream of or within tRNA processing. Part of nucleolar ribonuclease P complex. Is expressed in Meckel's cartilage and skeleton. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: ribonuclease MRP activity, ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonuclease MRP complex, ribonuclease P complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9DB28
Entrez ID: 117109
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Supt5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Supt5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Supt5 (suppressor of Ty 5, DSIF elongation factor subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription elongation, negative regulation of DNA-templated transcription, elongation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, elongation, positive regulation of macroautophagy, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of DNA-templated transcription elongation, regulation of transcription by RNA polymerase II, regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II; MF: chromatin binding, enzyme binding, mRNA binding, protein heterodimerization activity; CC: DSIF complex, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53, mRNA Capping
UniProt: O55201
Entrez ID: 20924
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cct3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cct3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cct3 (chaperonin containing TCP1 subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, chaperonin-containing T-complex, cytoplasm, microtubule, myelin sheath, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: P80318
Entrez ID: 12462
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ppa2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ppa2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ppa2 (pyrophosphatase (inorganic) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: diphosphate metabolic process, phosphate-containing compound metabolic process, regulation of mitochondrial membrane potential; MF: hydrolase activity, inorganic diphosphate phosphatase activity, magnesium ion binding, metal ion binding, protein serine/threonine phosphatase activity; CC: cytoplasm, mitochondrion, synapse
Pathways: Metabolism, Metabolism of proteins, Mitochondrial tRNA aminoacylation, Oxidative phosphorylation - Mus musculus (mouse), Pyrophosphate hydrolysis, Translation, tRNA Aminoacylation
UniProt: Q91VM9
Entrez ID: 74776
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Timm13
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Timm13 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Timm13 (translocase of inner mitochondrial membrane 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein transport; CC: fibrillar center, membrane, mitochondrial inner membrane, mitochondrial intermembrane space chaperone complex, mitochondrion
Pathways:
UniProt: P62075
Entrez ID: 30055
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Med22
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Med22 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Med22 (mediator complex subunit 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II; CC: core mediator complex, mediator complex, nucleoplasm, nucleus
Pathways:
UniProt: Q62276
Entrez ID: 20933
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pnkp
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pnkp in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pnkp (polynucleotide kinase 3'- phosphatase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via nonhomologous end joining, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of telomere maintenance, protein K63-linked ubiquitination, response to oxidative stress; MF: ATP binding, ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity, ATP-dependent polynucleotide 5'-hydroxyl-kinase activity, catalytic activity, hydrolase activity, kinase activity, nucleotide binding, polynucleotide 3'-phosphatase activity, transferase activity, ubiquitin-like ligase-substrate adaptor activity; CC: SCF ubiquitin ligase complex, nucleolus, nucleoplasm, nucleus, site of double-strand break
Pathways:
UniProt: E9Q9A5, G5E8N7, A0A0J9YUT2, A0A0J9YVH5, A0A140LIZ1, A0A0J9YUF9, A0A0J9YTV1, D3YZV7, A0A0J9YV48, A0A0J9YVJ6, A0A140LJ53
Entrez ID: 59047
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl14
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl14 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl14 (ribosomal protein L14)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including central nervous system; neural retina; nucleus pulposus; pancreas epithelium; and ureter. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human RPL14 (ribosomal protein L14). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CR57
Entrez ID: 67115
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Top2a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Top2a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Top2a (topoisomerase (DNA) II alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA topological change, apoptotic chromosome condensation, chromatin organization, chromosome condensation, chromosome segregation, embryonic cleavage, female meiosis chromosome separation, female meiotic nuclear division, hematopoietic progenitor cell differentiation, positive regulation of apoptotic process, positive regulation of single stranded viral RNA replication via double stranded DNA intermediate, positive regulation of transcription by RNA polymerase II, regulation of circadian rhythm, resolution of meiotic recombination intermediates, rhythmic process, sister chromatid segregation; MF: ATP binding, ATP-dependent activity, acting on DNA, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, chromatin binding, isomerase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase C binding, sequence-specific DNA binding, ubiquitin binding; CC: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex, centriole, chromosome, centromeric region, condensed chromosome, cytoplasm, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: Q01320
Entrez ID: 21973
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rac1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rac1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rac1 (Rac family small GTPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rac protein signal transduction, Wnt signaling pathway, planar cell polarity pathway, actin cytoskeleton organization, actin filament organization, actin filament polymerization, anatomical structure arrangement, angiotensin-activated signaling pathway involved in heart process, auditory receptor cell morphogenesis, axon guidance, bone resorption, cell adhesion, cell chemotaxis, cell migration, cell motility, cell projection assembly, cell-cell junction organization, cellular response to mechanical stimulus, cerebral cortex GABAergic interneuron development, cerebral cortex radially oriented cell migration, chemotaxis, cochlea morphogenesis, cortical cytoskeleton organization, cytoskeleton organization, dendrite development, dendrite morphogenesis, dopaminergic neuron differentiation, embryonic olfactory bulb interneuron precursor migration, endocytosis, engulfment of apoptotic cell, enzyme-linked receptor protein signaling pathway, epithelial cell morphogenesis, erythrocyte enucleation, establishment or maintenance of cell polarity, forebrain development, heart process, hepatocyte growth factor receptor signaling pathway, homeostasis of number of cells, homeostasis of number of cells within a tissue, hyperosmotic response, interneuron migration, lamellipodium assembly, localization within membrane, mast cell chemotaxis, midbrain dopaminergic neuron differentiation, motor neuron axon guidance, negative regulation of fibroblast migration, negative regulation of interleukin-23 production, neuron migration, neuron projection morphogenesis, non-canonical Wnt signaling pathway, phagocytosis, engulfment, positive regulation of DNA replication, positive regulation of actin filament polymerization, positive regulation of bicellular tight junction assembly, positive regulation of cell-substrate adhesion, positive regulation of dendritic spine development, positive regulation of endothelial cell migration, positive regulation of filopodium assembly, positive regulation of focal adhesion assembly, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of lamellipodium assembly, positive regulation of microtubule polymerization, positive regulation of neutrophil chemotaxis, positive regulation of ovarian follicle development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein phosphorylation, positive regulation of ruffle assembly, positive regulation of skeletal muscle acetylcholine-gated channel clustering, positive regulation of stress fiber assembly, positive regulation of substrate adhesion-dependent cell spreading, postsynaptic actin cytoskeleton organization, protein localization to plasma membrane, quinolinate biosynthetic process, regulation of ERK5 cascade, regulation of actin cytoskeleton organization, regulation of cell adhesion involved in heart morphogenesis, regulation of cell migration, regulation of cell morphogenesis, regulation of cell shape, regulation of fibroblast migration, regulation of lamellipodium assembly, regulation of neuron maturation, regulation of neuron migration, regulation of neuronal synaptic plasticity, regulation of neutrophil migration, regulation of nitric oxide biosynthetic process, regulation of postsynapse assembly, regulation of receptor signaling pathway via JAK-STAT, regulation of respiratory burst, regulation of stress fiber assembly, regulation of synaptic vesicle endocytosis, response to lipopolysaccharide, ruffle assembly, semaphorin-plexin signaling pathway, small GTPase-mediated signal transduction, sphingosine-1-phosphate receptor signaling pathway, substrate adhesion-dependent cell spreading, superoxide anion generation, synaptic transmission, GABAergic; MF: ATPase binding, G protein activity, GTP binding, GTP-dependent protein binding, GTPase activity, Rho GDP-dissociation inhibitor binding, enzyme binding, histone deacetylase binding, hydrolase activity, nucleotide binding, protein binding, protein kinase binding, protein-containing complex binding, small GTPase binding, thioesterase binding; CC: GABA-ergic synapse, Golgi membrane, NADPH oxidase complex, actin filament, cell cortex, cell projection, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic vesicle, cytoskeleton, cytosol, dendrite, early endosome membrane, glutamatergic synapse, kinocilium, lamellipodium, melanosome, membrane, nucleus, pericentriolar material, phagocytic cup, plasma membrane, postsynapse, postsynaptic membrane, presynaptic membrane, recycling endosome membrane, ruffle membrane, synapse, synaptic vesicle membrane, trans-Golgi network
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activated NTRK2 signals through FYN, Adaptive Immune System, Adherens junction - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), Azathioprine ADME, B cell receptor signaling pathway - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Beta-catenin independent WNT signaling, CD28 dependent Vav1 pathway, Cell death signalling via NRAGE, NRIF and NADE, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Co-stimulation by CD28, Colorectal cancer - Mus musculus (mouse), DAP12 interactions, DAP12 signaling, DCC mediated attractive signaling, Death Receptor Signaling, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Drug ADME, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB-mediated forward signaling, Ephrin signaling, Epstein-Barr virus infection - Mus musculus (mouse), FCERI mediated MAPK activation, Factors involved in megakaryocyte development and platelet production, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), GPVI-mediated activation cascade, Hemostasis, Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Intracellular signaling by second messengers, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), L1CAM interactions, Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK6/MAPK4 signaling, MET activates RAP1 and RAC1, MET promotes cell motility, NRAGE signals death through JNK, NTRK2 activates RAC1, Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nervous system development, Netrin-1 signaling, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PCP/CE pathway, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, Pancreatic cancer - Mus musculus (mouse), Pancreatic secretion - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Platelet activation, signaling and aggregation, Prion disease - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases Activate NADPH Oxidases, RHO GTPases Activate WASPs and WAVEs, RHO GTPases activate CIT, RHO GTPases activate IQGAPs, RHO GTPases activate KTN1, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Renal cell carcinoma - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Sema3A PAK dependent Axon repulsion, Sema4D in semaphorin signaling, Sema4D mediated inhibition of cell attachment and migration, Semaphorin interactions, Signal Transduction, Signal transduction by L1, Signaling by MET, Signaling by NTRK2 (TRKB), Signaling by NTRKs, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by VEGF, Signaling by WNT, Sphingolipid signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), p75 NTR receptor-mediated signalling
UniProt: P63001
Entrez ID: 19353
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Alg8
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Alg8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Alg8 (ALG8 alpha-1,3-glucosyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; MF: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification
UniProt: Q6P8H8
Entrez ID: 381903
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mphosph6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mphosph6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mphosph6 (M phase phosphoprotein 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of 5.8S rRNA, rRNA processing; MF: RNA binding, molecular_function; CC: cytoplasm, cytosol, exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D1Q1
Entrez ID: 68533
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Imp3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Imp3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Imp3 (IMP3, U3 small nucleolar ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, rRNA binding, snoRNA binding; CC: Mpp10 complex, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q921Y2
Entrez ID: 102462
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Adat2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Adat2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Adat2 (adenosine deaminase, tRNA-specific 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: tRNA processing, tRNA wobble adenosine to inosine editing; MF: catalytic activity, hydrolase activity, metal ion binding, tRNA-specific adenosine deaminase activity, tRNA-specific adenosine-34 deaminase activity, zinc ion binding
Pathways:
UniProt: Q6P6J0
Entrez ID: 66757
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tspyl1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tspyl1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tspyl1 (testis-specific protein, Y-encoded-like 1)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity; enzyme binding activity; and histone binding activity. Predicted to be involved in nucleosome assembly. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in gonadal dysgenesis and sudden infant death syndrome. Orthologous to several human genes including TSPYL1 (TSPY like 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: chromatin binding, enzyme binding, histone binding; CC: chromatin, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: O88852
Entrez ID: 22110
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hjurp
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Hjurp in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hjurp (Holliday junction recognition protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, chromosome segregation, regulation of protein-containing complex assembly; MF: DNA binding, histone binding, identical protein binding; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, Cyclin A/B1/B2 associated events during G2/M transition, Deposition of new CENPA-containing nucleosomes at the centromere, G2/M Transition, Mitotic G2-G2/M phases, Nucleosome assembly
UniProt: Q6PG16
Entrez ID: 381280
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ptpn11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ptpn11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ptpn11 (protein tyrosine phosphatase, non-receptor type 11)
Type: protein-coding
Summary: Enables cell adhesion molecule binding activity; non-membrane spanning protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of chondrocyte differentiation; positive regulation of cytokine production; and positive regulation of lipopolysaccharide-mediated signaling pathway. Acts upstream of or within several processes, including cell surface receptor signaling pathway; myeloid cell differentiation; and regulation of hormone secretion. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and retina. Used to study several diseases, including Noonan syndrome 1; hepatocellular adenoma; idiopathic scoliosis; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Bergmann glial cell differentiation, DNA damage checkpoint signaling, ERBB signaling pathway, atrioventricular canal development, axonogenesis, brain development, cellular response to epidermal growth factor stimulus, cellular response to mechanical stimulus, cerebellar cortex formation, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway, face morphogenesis, fibroblast growth factor receptor signaling pathway, genitalia development, glucose homeostasis, heart development, homeostasis of number of cells within a tissue, hormone metabolic process, hormone-mediated signaling pathway, inner ear development, integrin-mediated signaling pathway, intestinal epithelial cell migration, lipid metabolic process, megakaryocyte development, microvillus organization, multicellular organism growth, negative regulation of T cell proliferation, negative regulation of cell adhesion mediated by integrin, negative regulation of chondrocyte differentiation, negative regulation of cortisol secretion, negative regulation of growth hormone secretion, negative regulation of hormone secretion, negative regulation of insulin secretion, negative regulation of neutrophil activation, negative regulation of type I interferon production, neurotrophin TRK receptor signaling pathway, organ growth, peptidyl-tyrosine dephosphorylation, platelet formation, platelet-derived growth factor receptor signaling pathway, positive regulation of D-glucose import, positive regulation of ERK1 and ERK2 cascade, positive regulation of focal adhesion assembly, positive regulation of hormone secretion, positive regulation of insulin receptor signaling pathway, positive regulation of interferon-beta production, positive regulation of intracellular signal transduction, positive regulation of lipopolysaccharide-mediated signaling pathway, positive regulation of mitotic cell cycle, positive regulation of ossification, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of signal transduction, positive regulation of tumor necrosis factor production, positive regulation of type I interferon production, regulation of MAPK cascade, regulation of cell adhesion mediated by integrin, regulation of lipopolysaccharide-mediated signaling pathway, regulation of protein export from nucleus, regulation of protein-containing complex assembly, regulation of tumor necrosis factor production, triglyceride metabolic process, vasodilation; MF: D1 dopamine receptor binding, cadherin binding, cell adhesion molecule binding, hydrolase activity, insulin receptor binding, insulin receptor substrate binding, molecular adaptor activity, non-membrane spanning protein tyrosine phosphatase activity, peptide hormone receptor binding, phospholipase binding, phosphoprotein phosphatase activity, phosphotyrosine residue binding, protein binding, protein domain specific binding, protein kinase binding, protein tyrosine kinase binding, protein tyrosine phosphatase activity, receptor tyrosine kinase binding, signaling receptor complex adaptor activity; CC: cytoplasm, cytosol, nucleus, plasma membrane raft, protein-containing complex
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Cell surface interactions at the vascular wall, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Co-inhibition by BTLA, Co-inhibition by CTLA4, Co-inhibition by PD-1, Cytokine Signaling in Immune system, Developmental Biology, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, GAB1 signalosome, GPVI-mediated activation cascade, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Herpes simplex virus 1 infection - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Innate Immune System, Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, Interleukin-20 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-6 family signaling, Interleukin-6 signaling, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), MAPK family signaling cascades, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, MET activates PTPN11, MyD88-independent TLR4 cascade , Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PECAM1 interactions, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet homeostasis, Platelet sensitization by LDL, Proteoglycans in cancer - Mus musculus (mouse), RAF-independent MAPK1/3 activation, RET signaling, RNA Polymerase II Transcription, Ras signaling pathway - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Regulation of RUNX1 Expression and Activity, Regulation of T cell activation by CD28 family, Renal cell carcinoma - Mus musculus (mouse), Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by MET, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Spry regulation of FGF signaling, TRIF (TICAM1)-mediated TLR4 signaling , Tie2 Signaling, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Transcriptional regulation by RUNX1
UniProt: P35235
Entrez ID: 19247
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Vhl
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Vhl in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Vhl (von Hippel-Lindau tumor suppressor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid fibril formation, angiogenesis, blood vessel endothelial cell migration, camera-type eye morphogenesis, ciliary body morphogenesis, extracellular matrix organization, eye pigmentation, homeostasis of number of retina cells, iris morphogenesis, melanin metabolic process, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of cell population proliferation, negative regulation of endothelial cell differentiation, negative regulation of gene expression, negative regulation of hypoxia-inducible factor-1alpha signaling pathway, negative regulation of macromolecule biosynthetic process, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of signal transduction, negative regulation of thymocyte apoptotic process, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, neuron differentiation, pancreatic A cell differentiation, positive regulation of DNA-templated transcription, positive regulation of epithelial cell proliferation, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, protein transport, protein ubiquitination, regulation of DNA-templated transcription, regulation of apoptotic signaling pathway, regulation of catecholamine metabolic process, regulation of cellular response to hypoxia, regulation of gene expression, regulation of postsynapse organization, regulation of protein localization, regulation of thymocyte apoptotic process, regulation protein catabolic process at postsynapse, response to ethanol, response to hypoxia, type B pancreatic cell differentiation; MF: DNA-binding transcription factor binding, enzyme binding, molecular adaptor activity, protein binding, protein serine/threonine kinase binding, protein-containing complex binding, transcription elongation factor activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, VCB complex, cilium, cytoplasm, endoplasmic reticulum, glutamatergic synapse, membrane, microtubule cytoskeleton, nucleolus, nucleoplasm, nucleus, plasma membrane, postsynaptic density, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, HIF-1 signaling pathway - Mus musculus (mouse), Immune System, Metabolism of proteins, Neddylation, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, RHOBTB3 ATPase cycle, Renal cell carcinoma - Mus musculus (mouse), SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of ubiquitinylation proteins, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P40338
Entrez ID: 22346
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif3j1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif3j1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif3j1 (eukaryotic translation initiation factor 3, subunit J1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation; MF: identical protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q3UGC7
Entrez ID: 78655
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dph6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dph6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dph6 (diphthamine biosynthesis 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein histidyl modification to diphthamide; MF: ATP binding, diphthine-ammonia ligase activity, ligase activity, nucleotide binding
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2
UniProt: Q9CQ28
Entrez ID: 66632
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpp38
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpp38 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpp38 (ribonuclease P/MRP 38 subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: ribonuclease P RNA binding, ribonuclease P activity; CC: fibrillar center, multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonuclease MRP complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: A2AJG0
Entrez ID: 227522
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ube4b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ube4b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ube4b (ubiquitination factor E4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, granzyme-mediated apoptotic signaling pathway, neuron projection development, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autoubiquitination, protein catabolic process, protein folding, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, response to UV, response to endoplasmic reticulum stress, ubiquitin-dependent protein catabolic process, ventricular trabecula myocardium morphogenesis; MF: ATP binding, ATPase binding, enzyme binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, unfolded protein binding; CC: cytoplasm, nucleus, ubiquitin ligase complex
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9ES00
Entrez ID: 63958
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Polr1a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Polr1a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Polr1a (polymerase (RNA) I polypeptide A)
Type: protein-coding
Summary: Predicted to enable DNA/RNA hybrid binding activity; chromatin binding activity; and metal ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in negative regulation of protein localization to nucleolus and rRNA transcription. Located in chromosome and nucleus. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type and hypomyelinating leukodystrophy. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: DNA-templated transcription, negative regulation of protein localization to nucleolus, nucleolar large rRNA transcription by RNA polymerase I, rRNA transcription, transcription by RNA polymerase I; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, chromatin binding, magnesium ion binding, metal ion binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, chromatin, chromosome, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Mus musculus (mouse)
UniProt: O35134
Entrez ID: 20019
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rnaseh2a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rnaseh2a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rnaseh2a (ribonuclease H2, large subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, removal of RNA primer, RNA catabolic process, RNA metabolic process, mismatch repair; MF: RNA binding, RNA-DNA hybrid ribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding; CC: cytosol, nucleoplasm, nucleus, ribonuclease H2 complex
Pathways: DNA replication - Mus musculus (mouse)
UniProt: Q9CWY8
Entrez ID: 69724
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps26
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps26 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps26 (ribosomal protein S26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, negative regulation of RNA splicing, translation, translation at postsynapse, translation at presynapse; MF: mRNA binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, postsynapse, presynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62855
Entrez ID: 27370
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pde12
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pde12 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pde12 (phosphodiesterase 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to dsRNA, cellular response to interferon-alpha, cellular response to type II interferon, mRNA processing, mitochondrial mRNA catabolic process, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of viral genome replication, regulation of mitochondrial mRNA stability; MF: 3'-5'-RNA exonuclease activity, catalytic activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, poly(A)-specific ribonuclease activity; CC: mitochondrial matrix, mitochondrion
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Immune System, Interferon Signaling, OAS antiviral response
UniProt: Q3TIU4
Entrez ID: 211948
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cenpo
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cenpo in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cenpo (centromere protein O)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, centromere complex assembly, chromosome segregation; CC: Mis6-Sim4 complex, chromosome, chromosome, centromeric region, inner kinetochore, kinetochore, nuclear body, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8K015
Entrez ID: 52504
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl23
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl23 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl23 (mitochondrial ribosomal protein L23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: cytosolic ribosome, fibrillar center, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosomal subunit, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: O35972
Entrez ID: 19935
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ppp2r3c
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ppp2r3c in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ppp2r3c (protein phosphatase 2, regulatory subunit B'', gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell homeostasis, T cell homeostasis, cortical cytoskeleton organization, microtubule cytoskeleton organization, positive regulation of B cell differentiation, regulation of B cell activation, regulation of antimicrobial humoral response, regulation of dephosphorylation, regulation of mitochondrial depolarization, spleen development; MF: metal ion binding, protein binding; CC: Golgi apparatus, actin cytoskeleton, centrosome, cilium, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9JK24
Entrez ID: 59032
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpsa
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpsa in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpsa (ribosomal protein SA)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cytoplasmic translation, ribosomal small subunit assembly, translation; MF: DNA binding, laminin binding, laminin receptor activity, protein binding, ribosome binding, structural constituent of ribosome, structural molecule activity; CC: basement membrane, cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, glutamatergic synapse, membrane, neuronal cell body, nucleus, plasma membrane, postsynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P14206
Entrez ID: 16785
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dph1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dph1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dph1 (diphthamide biosynthesis 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fibroblast proliferation, protein histidyl modification to diphthamide; MF: 2-(3-amino-3-carboxypropyl)histidine synthase activity, 4 iron, 4 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, protein binding, transferase activity; CC: 2-(3-amino-3-carboxypropyl)histidine synthase complex, cell junction, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2
UniProt: Q5NCQ5
Entrez ID: 116905
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tcea1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tcea1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tcea1 (transcription elongation factor A (SII) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, erythrocyte differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: DNA binding, metal ion binding, nucleic acid binding, protein binding, zinc ion binding; CC: nucleolus, nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: DNA Repair, Dual incision in TC-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Nucleotide Excision Repair, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53
UniProt: P10711
Entrez ID: 21399
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Armc7
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Armc7 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Armc7 (armadillo repeat containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing
Pathways:
UniProt: Q3UJZ3
Entrez ID: 276905
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Supt4a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Supt4a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Supt4a (SPT4A, DSIF elongation factor subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, elongation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling; MF: RNA polymerase II complex binding, metal ion binding, protein heterodimerization activity, zinc ion binding; CC: DSIF complex, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: P63271
Entrez ID: 20922
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Coa6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Coa6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Coa6 (cytochrome c oxidase assembly factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, respiratory chain complex IV assembly; MF: copper ion binding; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm
Pathways: Thermogenesis - Mus musculus (mouse)
UniProt: Q8BGD8
Entrez ID: 67892
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gtf2b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gtf2b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gtf2b (general transcription factor IIB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II core complex assembly, RNA polymerase II preinitiation complex assembly, chromatin remodeling, chromosome organization, gene expression, meiotic sister chromatid cohesion, protein acetylation, spindle assembly, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription preinitiation complex assembly, transcriptional start site selection at RNA polymerase II promoter, viral transcription; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II complex binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, metal ion binding, nuclear thyroid hormone receptor binding, promoter-specific chromatin binding, protein binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cell division site, chromosome, condensed chromosome, germinal vesicle, kinetochore, nuclear body, nucleoplasm, nucleus, protein-DNA complex, transcription factor TFIID complex, transcription preinitiation complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Spinocerebellar ataxia - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P62915
Entrez ID: 229906
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dnajc9
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dnajc9 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dnajc9 (DnaJ heat shock protein family (Hsp40) member C9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly; MF: heat shock protein binding, histone binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, extracellular space, membrane, nucleoplasm, nucleus, plasma membrane, protein folding chaperone complex
Pathways:
UniProt: Q91WN1
Entrez ID: 108671
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Wdr48
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Wdr48 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Wdr48 (WD repeat domain 48)
Type: protein-coding
Summary: Predicted to enable DNA binding activity; deubiquitinase activator activity; and ubiquitin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; regulation of protein monoubiquitination; and seminiferous tubule development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in femur. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, cell surface receptor signaling pathway via JAK-STAT, double-strand break repair via homologous recombination, embryonic organ development, homeostasis of number of cells, male gonad development, multicellular organism growth, positive regulation of double-strand break repair via homologous recombination, positive regulation of epithelial cell proliferation, positive regulation of receptor signaling pathway via JAK-STAT, regulation of macromolecule metabolic process, regulation of primary metabolic process, regulation of protein monoubiquitination, seminiferous tubule development, single fertilization, skeletal system morphogenesis, skin development, spermatogenesis; MF: DNA binding, deubiquitinase activator activity, double-stranded DNA binding, single-stranded DNA binding, ubiquitin binding; CC: cytoplasm, endosome, late endosome, lysosome, nucleus
Pathways: DNA Damage Bypass, DNA Repair, Deubiquitination, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex, Ub-specific processing proteases
UniProt: Q8BH57
Entrez ID: 67561
|
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