screen_file
string | organism
string | perturbation
string | gene
string | cell
string | phenotype
string | hit
int64 | benchmark_type
string | prompt
string | gene_context
string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Tcea1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Tcea1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Tcea1 (transcription elongation factor A (SII) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, erythrocyte differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: DNA binding, metal ion binding, nucleic acid binding, protein binding, zinc ion binding; CC: nucleolus, nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: DNA Repair, Dual incision in TC-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Nucleotide Excision Repair, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53
UniProt: P10711
Entrez ID: 21399
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Armc7
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Armc7 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Armc7 (armadillo repeat containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing
Pathways:
UniProt: Q3UJZ3
Entrez ID: 276905
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Supt4a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Supt4a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Supt4a (SPT4A, DSIF elongation factor subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, elongation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling; MF: RNA polymerase II complex binding, metal ion binding, protein heterodimerization activity, zinc ion binding; CC: DSIF complex, nucleoplasm, nucleus
Pathways: Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: P63271
Entrez ID: 20922
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Coa6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Coa6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Coa6 (cytochrome c oxidase assembly factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, respiratory chain complex IV assembly; MF: copper ion binding; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm
Pathways: Thermogenesis - Mus musculus (mouse)
UniProt: Q8BGD8
Entrez ID: 67892
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gtf2b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gtf2b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gtf2b (general transcription factor IIB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II core complex assembly, RNA polymerase II preinitiation complex assembly, chromatin remodeling, chromosome organization, gene expression, meiotic sister chromatid cohesion, protein acetylation, spindle assembly, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription preinitiation complex assembly, transcriptional start site selection at RNA polymerase II promoter, viral transcription; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II complex binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, acetyltransferase activity, acyltransferase activity, histone acetyltransferase activity, metal ion binding, nuclear thyroid hormone receptor binding, promoter-specific chromatin binding, protein binding, protein-lysine-acetyltransferase activity, transferase activity, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cell division site, chromosome, condensed chromosome, germinal vesicle, kinetochore, nuclear body, nucleoplasm, nucleus, protein-DNA complex, transcription factor TFIID complex, transcription preinitiation complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Spinocerebellar ataxia - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: P62915
Entrez ID: 229906
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dnajc9
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dnajc9 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dnajc9 (DnaJ heat shock protein family (Hsp40) member C9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly; MF: heat shock protein binding, histone binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, extracellular space, membrane, nucleoplasm, nucleus, plasma membrane, protein folding chaperone complex
Pathways:
UniProt: Q91WN1
Entrez ID: 108671
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Wdr48
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Wdr48 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Wdr48 (WD repeat domain 48)
Type: protein-coding
Summary: Predicted to enable DNA binding activity; deubiquitinase activator activity; and ubiquitin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; regulation of protein monoubiquitination; and seminiferous tubule development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in femur. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, cell surface receptor signaling pathway via JAK-STAT, double-strand break repair via homologous recombination, embryonic organ development, homeostasis of number of cells, male gonad development, multicellular organism growth, positive regulation of double-strand break repair via homologous recombination, positive regulation of epithelial cell proliferation, positive regulation of receptor signaling pathway via JAK-STAT, regulation of macromolecule metabolic process, regulation of primary metabolic process, regulation of protein monoubiquitination, seminiferous tubule development, single fertilization, skeletal system morphogenesis, skin development, spermatogenesis; MF: DNA binding, deubiquitinase activator activity, double-stranded DNA binding, single-stranded DNA binding, ubiquitin binding; CC: cytoplasm, endosome, late endosome, lysosome, nucleus
Pathways: DNA Damage Bypass, DNA Repair, Deubiquitination, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Metabolism of proteins, Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex, Ub-specific processing proteases
UniProt: Q8BH57
Entrez ID: 67561
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Snupn
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Snupn in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Snupn (snurportin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA import into nucleus, cytoskeleton organization, protein complex oligomerization, protein import into nucleus, protein tetramerization, snRNA import into nucleus; MF: RNA binding, RNA cap binding, molecular_function, nuclear import signal receptor activity; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytosol, nuclear pore, nucleoplasm, nucleus, plasma membrane
Pathways: Metabolism of RNA, Metabolism of non-coding RNA, Nucleocytoplasmic transport - Mus musculus (mouse), snRNP Assembly
UniProt: Q80W37
Entrez ID: 66069
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nop9
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nop9 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nop9 (NOP9 nucleolar protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal small subunit export from nucleus; MF: RNA binding; CC: 90S preribosome, nucleolus, preribosome, small subunit precursor
Pathways:
UniProt: Q8BMC4
Entrez ID: 67842
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dolpp1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dolpp1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dolpp1 (dolichyl pyrophosphate phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein N-linked glycosylation, protein glycosylation; MF: dolichyldiphosphatase activity, hydrolase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolism of proteins, N-Glycan biosynthesis - Mus musculus (mouse), Post-translational protein modification, Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis
UniProt: Q9JMF7
Entrez ID: 57170
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Frat2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Frat2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Frat2 (frequently rearranged in advanced T cell lymphomas 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, canonical Wnt signaling pathway, regulation of protein export from nucleus; CC: cytoplasm, nucleus
Pathways: Alzheimer disease - Mus musculus (mouse), Beta-catenin phosphorylation cascade, Breast cancer - Mus musculus (mouse), Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q8K025
Entrez ID: 212398
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ddx1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ddx1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ddx1 (DEAD box helicase 1)
Type: protein-coding
Summary: Enables double-stranded RNA binding activity. Involved in positive regulation of canonical NF-kappaB signal transduction and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytoplasmic stress granule; cytosol; and mitochondrion. Is expressed in several structures, including 1st branchial arch; blastocyst; central nervous system; early embryo; and genitourinary system. Orthologous to human DDX1 (DEAD-box helicase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: defense response to virus, double-strand break repair, immune system process, innate immune response, mRNA processing, positive regulation of canonical NF-kappaB signal transduction, positive regulation of myeloid dendritic cell cytokine production, protein localization to cytoplasmic stress granule, response to exogenous dsRNA, response to virus, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA/RNA helicase activity, RNA binding, RNA helicase activity, chromatin binding, double-stranded RNA binding, exonuclease activity, helicase activity, hydrolase activity, nuclease activity, nucleic acid binding, nucleotide binding, poly(A) binding, protein binding, transcription coregulator activity; CC: cleavage body, cytoplasm, cytoplasmic stress granule, cytosol, mitochondrion, nucleoplasm, nucleus, ribonucleoprotein complex, tRNA-splicing ligase complex
Pathways:
UniProt: Q91VR5
Entrez ID: 104721
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lsg1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lsg1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lsg1 (large 60S subunit nuclear export GTPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear export, protein transport, ribosomal subunit export from nucleus; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: Cajal body, cytoplasm, cytosol, endoplasmic reticulum, nuclear body, nucleoplasm, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse), cyclic AMP biosynthesis
UniProt: Q3UM18
Entrez ID: 224092
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Snrpd3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Snrpd3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Snrpd3 (small nuclear ribonucleoprotein D3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding, U7 snRNA binding, enzyme binding, histone pre-mRNA DCP binding, telomerase RNA binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, commitment complex, cytoplasm, cytosol, methylosome, nuclear body, nucleoplasm, nucleus, pICln-Sm protein complex, precatalytic spliceosome, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex, telomerase holoenzyme complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62320
Entrez ID: 67332
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Bccip
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Bccip in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Bccip (BRCA2 and CDKN1A interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, establishment of mitotic spindle orientation, microtubule anchoring, microtubule cytoskeleton organization, mitotic spindle assembly, mitotic spindle organization, neuroendocrine cell differentiation; MF: kinase regulator activity, tubulin binding; CC: centriole, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle pole, nuclear cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: Q9CWI3
Entrez ID: 66165
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pgk1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pgk1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pgk1 (phosphoglycerate kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: canonical glycolysis, cellular response to hypoxia, epithelial cell differentiation, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, glycolytic process, negative regulation of angiogenesis, negative regulation of pyruvate decarboxylation to acetyl-CoA, plasminogen activation; MF: ADP binding, ATP binding, kinase activity, metal ion binding, nucleotide binding, phosphoglycerate kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-disulfide reductase [NAD(P)H] activity, transferase activity, transmembrane transporter binding; CC: cytoplasm, cytosol, extracellular space, membrane raft, mitochondrial matrix, mitochondrion
Pathways: Gluconeogenesis, Glucose metabolism, Glycolysis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, gluconeogenesis I, glycolysis I, glycolysis III
UniProt: P09411
Entrez ID: 18655
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dhps
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dhps in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dhps (deoxyhypusine synthase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose homeostasis, positive regulation of T cell proliferation, protein maturation, spermidine catabolic process, spermidine metabolic process; MF: deoxyhypusine synthase activity, identical protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification
UniProt: Q3TXU5
Entrez ID: 330817
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pabpc1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pabpc1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pabpc1 (poly(A) binding protein, cytoplasmic 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CRD-mediated mRNA stabilization, RNA splicing, mRNA processing, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of cytoplasmic translation, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, regulatory ncRNA-mediated gene silencing; MF: RNA binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding, poly(A) binding, poly(U) RNA binding, protein binding; CC: catalytic step 2 spliceosome, cell leading edge, cell projection, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, lamellipodium, mCRD-mediated mRNA stability complex, nucleus, protein-containing complex, ribonucleoprotein complex, spliceosomal complex, synapse
Pathways: AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Eukaryotic Translation Initiation, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Translation, Translation initiation complex formation, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P29341
Entrez ID: 18458
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rps18
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rps18 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rps18 (ribosomal protein S18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, nucleic acid binding, protein binding, protein kinase binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleus, postsynapse, postsynaptic density, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62270
Entrez ID: 20084
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Zc3h18
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Zc3h18 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Zc3h18 (zinc finger CCCH-type containing 18)
Type: protein-coding
Summary: Predicted to enable mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Predicted to be involved in RNA destabilization. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Is expressed in respiratory system cartilage; sensory organ; skeleton; and vibrissa. Orthologous to human ZC3H18 (zinc finger CCCH-type containing 18). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: MF: mRNA cap binding complex binding, metal ion binding, protein-macromolecule adaptor activity, zinc ion binding; CC: nuclear speck, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: Metabolism of RNA, Nuclear RNA decay
UniProt: Q0P678
Entrez ID: 76014
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mfap1b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mfap1b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mfap1b (microfibrillar-associated protein 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; CC: U2-type precatalytic spliceosome, U2-type spliceosomal complex, centrosome, extracellular matrix, microfibril, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: C0HKD9, C0HKD8
Entrez ID: 100034361
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cpsf2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cpsf2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cpsf2 (cleavage and polyadenylation specific factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing; MF: RNA binding; CC: glutamatergic synapse, mRNA cleavage and polyadenylation specificity factor complex, nucleus, postsynapse
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: O35218
Entrez ID: 51786
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Actr2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Actr2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Actr2 (actin related protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin cytoskeleton organization, asymmetric cell division, cellular response to type II interferon, cilium assembly, cytosolic transport, establishment or maintenance of cell polarity, meiotic cell cycle, meiotic chromosome movement towards spindle pole, meiotic cytokinesis, positive regulation of dendritic spine morphogenesis, positive regulation of double-strand break repair via homologous recombination, positive regulation of lamellipodium assembly, positive regulation of transcription by RNA polymerase II, regulation of double-strand break repair via nonhomologous end joining, spindle localization; MF: ATP binding, actin binding, actin filament binding, cytoskeletal protein binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cap, cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, lamellipodium, nucleus, podosome core, postsynapse, site of double-strand break
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Clathrin-mediated endocytosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Mus musculus (mouse), Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Membrane Trafficking, Nervous system development, Neutrophil degranulation, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, Yersinia infection - Mus musculus (mouse)
UniProt: P61161
Entrez ID: 66713
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mlst8
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mlst8 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mlst8 (MTOR associated protein, LST8 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, TOR signaling, TORC1 signaling, TORC2 signaling, cellular response to hypoxia, cellular response to nutrient levels, cellular response to osmotic stress, cytoskeleton organization, negative regulation of apoptotic process, negative regulation of autophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of TOR signaling, positive regulation of actin filament polymerization, positive regulation of cell growth, positive regulation of glycolytic process, positive regulation of lipid biosynthetic process, positive regulation of pentose-phosphate shunt, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of actin cytoskeleton organization; MF: protein serine/threonine kinase activator activity, protein-macromolecule adaptor activity; CC: TORC1 complex, TORC2 complex, cytoplasm, lysosomal membrane, lysosome, membrane, serine/threonine protein kinase complex
Pathways: Adaptive Immune System, Amino acids regulate mTORC1, Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, Cellular response to heat stress, Cellular response to starvation, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Cellular responses to stress, Co-stimulation by CD28, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, HSF1-dependent transactivation, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, PI3K-Akt signaling pathway - Mus musculus (mouse), PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, TP53 Regulates Metabolic Genes, Thermogenesis - Mus musculus (mouse), Transcriptional Regulation by TP53, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q9DCJ1
Entrez ID: 56716
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Psmb2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Psmb2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Psmb2 (proteasome (prosome, macropain) subunit, beta type 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9R1P3
Entrez ID: 26445
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Utp15
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Utp15 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Utp15 (UTP15 small subunit processome component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; CC: cytoplasm, endoplasmic reticulum, fibrillar center, nucleolus, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8C7V3
Entrez ID: 105372
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Clasrp
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Clasrp in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Clasrp (CLK4-associating serine/arginine rich protein)
Type: protein-coding
Summary: The protein encoded by this gene contains serine/arginine (SR) dipeptide repeat domains, and is thought to be involved in the regulation of alternative splicing. This protein is thought to interact with, and be phosphorylated by, Clk4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8CFC7
Entrez ID: 53609
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Eif1ax
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Eif1ax in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Eif1ax (eukaryotic translation initiation factor 1A, X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosome assembly, translation, translational initiation; MF: RNA binding, protein binding, tRNA binding, translation initiation factor activity; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, multi-eIF complex, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q8BMJ3
Entrez ID: 66235
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ndufb3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ndufb3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ndufb3 (NADH:ubiquinone oxidoreductase subunit B3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, electron transport chain, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQZ6
Entrez ID: 66495
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl49
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl49 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl49 (mitochondrial ribosomal protein L49)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including central nervous system; early conceptus; gonad; liver; and retina. Orthologous to human MRPL49 (mitochondrial ribosomal protein L49). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CQ40
Entrez ID: 18120
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rtn4ip1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rtn4ip1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rtn4ip1 (reticulon 4 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, regulation of dendrite development, ubiquinone biosynthetic process; MF: NADPH dehydrogenase (quinone) activity, nucleotide binding, oxidoreductase activity, zinc ion binding; CC: membrane, mitochondrial matrix, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q924D0
Entrez ID: 170728
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Itpk1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Itpk1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Itpk1 (inositol 1,3,4-triphosphate 5/6 kinase)
Type: protein-coding
Summary: Predicted to enable inositol phosphate kinase activity. Acts upstream of or within neural tube development. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and peripheral nervous system. Orthologous to human ITPK1 (inositol-tetrakisphosphate 1-kinase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: inositol trisphosphate metabolic process, necroptotic process, neural tube development; MF: ATP binding, hydrolase activity, inositol-1,3,4,5-tetrakisphosphate 6-kinase activity, inositol-1,3,4-trisphosphate 5-kinase activity, inositol-1,3,4-trisphosphate 6-kinase activity, inositol-3,4,5,6-tetrakisphosphate 1-kinase activity, inositol-3,4,6-trisphosphate 1-kinase activity, isomerase activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, transferase activity
Pathways: 1D-<i>myo</i>-inositol hexakisphosphate biosynthesis II (mammalian), D-<i>myo</i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis, Factors involved in megakaryocyte development and platelet production, Hemostasis, Inositol phosphate metabolism, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Synthesis of IP3 and IP4 in the cytosol, Synthesis of pyrophosphates in the cytosol
UniProt: Q8BYN3
Entrez ID: 217837
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cpsf1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cpsf1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cpsf1 (cleavage and polyadenylation specific factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, mRNA processing; MF: RNA binding, enzyme binding, mRNA 3'-UTR AU-rich region binding, nucleic acid binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9EPU4
Entrez ID: 94230
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dhx37
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dhx37 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dhx37 (DEAH-box helicase 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of male gonad development, ribosomal small subunit biogenesis, ribosome assembly, ribosome biogenesis; MF: ATP binding, RNA binding, U3 snoRNA binding, helicase activity, nucleic acid binding, nucleotide binding; CC: cytoplasm, nuclear membrane, nucleolus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: A0A0G2JG97, Q6NZL1, A0A0G2JG93
Entrez ID: 208144
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Slc4a7
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Slc4a7 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Slc4a7 (solute carrier family 4, sodium bicarbonate cotransporter, member 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: auditory receptor cell development, bicarbonate transport, camera-type eye photoreceptor cell differentiation, cellular response to growth factor stimulus, cochlear nucleus development, inorganic anion transport, locomotory exploration behavior, monoatomic anion transmembrane transport, monoatomic anion transport, monoatomic ion transport, phagosome acidification, purine nucleotide biosynthetic process, pyrimidine nucleotide biosynthetic process, regulation of intracellular pH, retina vasculature morphogenesis in camera-type eye, retinal cell programmed cell death, sensory perception of sound, sodium ion transmembrane transport, sodium ion transport, transmembrane transport, visual perception; MF: bicarbonate transmembrane transporter activity, monoatomic anion transmembrane transporter activity, protein binding, secondary active transmembrane transporter activity, sodium ion transmembrane transporter activity, sodium:bicarbonate symporter activity, solute:inorganic anion antiporter activity, symporter activity; CC: apical plasma membrane, basolateral plasma membrane, cell projection, cytoplasm, cytoplasmic vesicle, membrane, plasma membrane, stereocilium
Pathways:
UniProt: H6WZF5, I1VGT6, I1VGT5, E3UVT9, E3UVT8, H6WZ45, J9RV59, I1VGT4, D3Y272, D3Y273, F8VQC9, J9RDH0, J9RZB2, J9S4N6, U3RF68, J9S7F7, A0A286YDR1, A0A286YDJ7, A0A286YD46, A0A286YCX2, A0A286YCS4, A0A286YDK8, A0A286YCX8
Entrez ID: 218756
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ect2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ect2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ect2 (ect2 oncogene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of GTPase activity, activation of protein kinase activity, bicellular tight junction assembly, cell differentiation, cell division, cell morphogenesis, cellular response to calcium ion, cellular response to hydrogen peroxide, cellular response to ionizing radiation, intracellular signal transduction, mitotic cytokinesis, nervous system development, positive regulation of GTPase activity, positive regulation of apoptotic process, positive regulation of cytokinesis, positive regulation of mitotic cytokinetic process, positive regulation of neuron differentiation, positive regulation of protein import into nucleus, protein homooligomerization, protein transport, regulation of attachment of spindle microtubules to kinetochore, regulation of cytokinesis, actomyosin contractile ring assembly, regulation of protein kinase activity; MF: GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding, protein homodimerization activity, small GTPase binding; CC: anchoring junction, bicellular tight junction, cell cortex, cell-cell junction, centralspindlin complex, cleavage furrow, cytoplasm, cytoskeleton, cytosol, midbody, mitotic spindle, nuclear body, nucleoplasm, nucleus, spindle
Pathways: CDC42 GTPase cycle, Cell death signalling via NRAGE, NRIF and NADE, Death Receptor Signaling, G alpha (12/13) signalling events, GPCR downstream signalling, NRAGE signals death through JNK, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, Signal Transduction, Signaling by GPCR, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling
UniProt: Q07139
Entrez ID: 13605
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gins1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gins1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gins1 (GINS complex subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA strand elongation involved in mitotic DNA replication, inner cell mass cell proliferation; CC: CMG complex, GINS complex, chromosome, cytoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q9CZ15
Entrez ID: 69270
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mkln1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mkln1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mkln1 (muskelin 1, intracellular mediator containing kelch motifs)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, cell-matrix adhesion, neurotransmitter receptor transport postsynaptic membrane to endosome, regulation of cell shape, regulation of receptor internalization, vesicle-mediated transport in synapse; MF: identical protein binding, protein binding, protein homodimerization activity; CC: GABA-ergic synapse, cell cortex, cell projection, cytoplasm, cytosol, nucleoplasm, nucleus, postsynapse, postsynaptic endosome membrane, postsynaptic specialization membrane of symmetric synapse, ruffle, synapse, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: O89050
Entrez ID: 27418
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Eif5a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Eif5a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Eif5a (eukaryotic translation initiation factor 5A)
Type: protein-coding
Summary: This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cellular response to virus, negative regulation of apoptotic process, positive regulation of apoptotic process, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cytosolic calcium ion concentration, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of muscle cell differentiation, positive regulation of reactive oxygen species metabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation, tumor necrosis factor-mediated signaling pathway; MF: RNA binding, U6 snRNA binding, ribosome binding, translation elongation factor activity; CC: annulate lamellae, cytoplasm, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuronal cell body, nuclear pore, nucleus, synapse
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification
UniProt: P63242
Entrez ID: 276770
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Taf13
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Taf13 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Taf13 (TATA-box binding protein associated factor 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, TBP-class protein binding, protein binding, protein heterodimerization activity; CC: nucleolus, nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: P61216
Entrez ID: 99730
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ipmk
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ipmk in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ipmk (inositol polyphosphate multikinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: inositol phosphate biosynthetic process, inositol trisphosphate metabolic process, lipid metabolic process, necroptotic process, neural tube formation, phosphatidylinositol metabolic process; MF: 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, ATP binding, flavonoid binding, inositol tetrakisphosphate kinase activity, inositol-1,3,4,5-tetrakisphosphate 6-kinase activity, inositol-1,3,4,6-tetrakisphosphate 5-kinase activity, inositol-1,4,5,6-tetrakisphosphate 3-kinase activity, inositol-1,4,5-trisphosphate 3-kinase activity, inositol-1,4,5-trisphosphate 6-kinase activity, kinase activity, metal ion binding, nucleotide binding, transferase activity; CC: ciliary basal body, cytoplasm, nucleoplasm, nucleus
Pathways: Inositol phosphate metabolism - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse)
UniProt: Q7TT16
Entrez ID: 69718
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rps17
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rps17 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rps17 (ribosomal protein S17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, erythrocyte homeostasis, rRNA processing, ribosomal small subunit biogenesis, translation; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63276
Entrez ID: 20068
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dnajc8
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dnajc8 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dnajc8 (DnaJ heat shock protein family (Hsp40) member C8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: Hsp70 protein binding; CC: cytosol, intercellular bridge, nucleoplasm, nucleus
Pathways:
UniProt: Q6NZB0
Entrez ID: 68598
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Smc4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Smc4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Smc4 (structural maintenance of chromosomes 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromosome condensation, chromosome organization, kinetochore organization, meiotic cell cycle, meiotic chromosome condensation, meiotic chromosome segregation, mitotic chromosome condensation, nuclear chromosome segregation, nuclear division, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation, single strand break repair; MF: ATP binding, ATP hydrolysis activity, chromatin binding, nucleotide binding, protein binding, single-stranded DNA binding; CC: chromosome, chromosome, centromeric region, condensed nuclear chromosome, condensin complex, cytoplasm, cytosol, nuclear lumen, nuclear speck, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Condensation of Prometaphase Chromosomes, Condensation of Prophase Chromosomes, M Phase, Mitotic Prometaphase, Mitotic Prophase
UniProt: Q8CG47
Entrez ID: 70099
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pggt1b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pggt1b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pggt1b (protein geranylgeranyltransferase type I, beta subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell cycle, positive regulation of cell population proliferation, protein geranylgeranylation; MF: CAAX-protein geranylgeranyltransferase activity, catalytic activity, heterocyclic compound binding, metal ion binding, peptide binding, prenyltransferase activity, protein geranylgeranyltransferase activity, protein prenyltransferase activity, small molecule binding, transferase activity, zinc ion binding; CC: CAAX-protein geranylgeranyltransferase complex
Pathways:
UniProt: Q8BUY9
Entrez ID: 225467
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cars2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cars2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cars2 (cysteinyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cysteinyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, cysteine-tRNA ligase activity, ligase activity, metal ion binding, nucleotide binding; CC: cytoplasm, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8BYM8
Entrez ID: 71941
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ndrg3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ndrg3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ndrg3 (N-myc downstream regulated gene 3)
Type: protein-coding
Summary: Involved in decidualization. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; forelimb interdigital region mesenchyme; genitourinary system; and thymus primordium. Orthologous to human NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: decidualization, signal transduction; CC: cytoplasm
Pathways:
UniProt: Q9QYF9
Entrez ID: 29812
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ak2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ak2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ak2 (adenylate kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ADP biosynthetic process, AMP metabolic process, ATP metabolic process, nucleobase-containing compound metabolic process, nucleoside monophosphate phosphorylation; MF: AMP kinase activity, ATP binding, kinase activity, nucleobase-containing compound kinase activity, nucleotide binding, phosphotransferase activity, phosphate group as acceptor, transferase activity; CC: cytoplasm, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, sperm flagellum, sperm mitochondrial sheath
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), Thiamine metabolism - Mus musculus (mouse), adenosine nucleotides <i>de novo</i> biosynthesis, purine and pyrimidine metabolism
UniProt: Q9WTP6
Entrez ID: 11637
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nolc1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nolc1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nolc1 (nucleolar and coiled-body phosphoprotein 1)
Type: protein-coding
Summary: Predicted to enable several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Acts upstream of or within nucleolus organization. Located in Cajal body and nucleolus. Is expressed in 1-cell stage embryo; cerebral cortex ventricular layer; and cortical plate. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: box H/ACA sno(s)RNA metabolic process, neural crest cell development, neural crest formation, nucleolus organization, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, regulation of protein import into nucleus, regulation of translation; MF: TFIIB-class transcription factor binding, box C/D methylation guide snoRNP complex binding, box C/D sno(s)RNA binding, box H/ACA snoRNA binding, box H/ACA snoRNP complex binding, molecular function inhibitor activity, nuclear localization sequence binding, protein domain specific binding, protein heterodimerization activity, protein kinase inhibitor activity, protein-macromolecule adaptor activity; CC: Cajal body, box C/D methylation guide snoRNP complex, box H/ACA snoRNP complex, cytoplasm, fibrillar center, nucleolus, nucleoplasm, nucleus, small nuclear ribonucleoprotein complex
Pathways:
UniProt: E9Q5C9
Entrez ID: 70769
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Uqcrfs1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Uqcrfs1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Uqcrfs1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, ubiquinol to cytochrome c, proton transmembrane transport, respiratory electron transport chain, response to hormone, response to xenobiotic stimulus; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, protein binding, protein-containing complex binding, quinol-cytochrome-c reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, myelin sheath, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CR68
Entrez ID: 66694
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ppih
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ppih in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ppih (peptidyl prolyl isomerase H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, positive regulation of viral genome replication, protein folding; MF: cyclosporin A binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity, ribonucleoprotein complex binding; CC: U4/U6 snRNP, U4/U6 x U5 tri-snRNP complex, cytoplasm, intracellular membrane-bounded organelle, nuclear speck, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9D868
Entrez ID: 66101
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Fam32a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Fam32a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Fam32a (family with sequence similarity 32, member A)
Type: protein-coding
Summary: Predicted to be involved in apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to human FAM32A (family with sequence similarity 32 member A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, biological_process; CC: nucleolus, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9CR80
Entrez ID: 67922
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ss18
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ss18 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ss18 (SS18, subunit of BAF chromatin remodeling complex)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell morphogenesis, chromatin remodeling, cytoskeleton organization, ephrin receptor signaling pathway, intracellular signal transduction, microtubule cytoskeleton organization, negative regulation of cell differentiation, neuronal stem cell population maintenance, positive regulation of cell population proliferation, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, response to xenobiotic stimulus; MF: transcription coactivator activity; CC: GBAF complex, SWI/SNF complex, chromatin, microtubule cytoskeleton, npBAF complex, nucleoplasm, nucleus
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, SWI/SNF chromatin remodelers, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q62280
Entrez ID: 268996
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ppp6c
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ppp6c in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ppp6c (protein phosphatase 6, catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cGAS/STING signaling pathway, immune system process, innate immune response, negative regulation of cGAS/STING signaling pathway; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cell Cycle, Chromosome Maintenance, ER to Golgi Anterograde Transport, Extension of Telomeres, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Telomere Extension By Telomerase, Telomere Maintenance, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9CQR6
Entrez ID: 67857
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Prpf19
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Prpf19 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Prpf19 (pre-mRNA processing factor 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, RNA splicing, double-strand break repair via nonhomologous end joining, inner cell mass cell proliferation, intracellular protein localization, lipid biosynthetic process, mRNA processing, mRNA splicing, via spliceosome, negative regulation of neuron differentiation, positive regulation of astrocyte differentiation, positive regulation of mRNA splicing, via spliceosome, positive regulation of neuron differentiation, proteasomal protein catabolic process, protein K63-linked ubiquitination, protein polyubiquitination, protein ubiquitination, spliceosomal complex assembly, spliceosomal tri-snRNP complex assembly; MF: identical protein binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: DNA replication factor A complex, Prp19 complex, U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, cytoplasm, cytoskeleton, lipid droplet, nuclear speck, nucleoplasm, nucleus, site of double-strand break, spindle, spliceosomal complex
Pathways: DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Metabolism of RNA, Nucleotide Excision Repair, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER), Ubiquitin mediated proteolysis - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q99KP6
Entrez ID: 28000
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sec13
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sec13 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sec13 (SEC13 homolog, nuclear pore and COPII coat complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII-coated vesicle budding, COPII-coated vesicle cargo loading, cellular response to nutrient levels, endoplasmic reticulum to Golgi vesicle-mediated transport, mRNA transport, nucleocytoplasmic transport, positive regulation of TOR signaling, positive regulation of TORC1 signaling, protein exit from endoplasmic reticulum, protein import into nucleus, protein localization to plasma membrane, protein transport, vesicle-mediated transport; MF: identical protein binding, structural molecule activity; CC: COPII vesicle coat, ER to Golgi transport vesicle membrane, GATOR2 complex, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, kinetochore, lysosomal membrane, lysosome, membrane, nuclear envelope, nuclear pore, nuclear pore outer ring, nucleoplasm, nucleus, protein-containing complex
Pathways: Adaptive Immune System, Amino acids regulate mTORC1, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Immune System, Inositol phosphate metabolism, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, Protein processing in endoplasmic reticulum - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, mTOR signaling pathway - Mus musculus (mouse), snRNP Assembly
UniProt: Q9D1M0
Entrez ID: 110379
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mpi
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mpi in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mpi (mannose phosphate isomerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GDP-D-mannose biosynthetic process from fructose-6-phosphate, GDP-mannose biosynthetic process, carbohydrate metabolic process, glycolytic process from mannose through fructose-6-phosphate, mannose to fructose-6-phosphate catabolic process; MF: isomerase activity, mannose-6-phosphate isomerase activity, metal ion binding, zinc ion binding; CC: cytoplasm, cytosol
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, D-mannose degradation, Fructose and mannose metabolism - Mus musculus (mouse), GDP-mannose biosynthesis, GDP-mannose biosynthesis I, GDP-mannose metabolism, Metabolism of proteins, Post-translational protein modification, Synthesis of GDP-mannose, Synthesis of substrates in N-glycan biosythesis, colanic acid building blocks biosynthesis, mannitol degradation II
UniProt: Q924M7
Entrez ID: 110119
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Urb1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Urb1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Urb1 (URB1 ribosome biogenesis 1 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); CC: fibrillar center, nucleolus, nucleus
Pathways:
UniProt: Q571H0
Entrez ID: 207932
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Elp4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Elp4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Elp4 (elongator acetyltransferase complex subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of transcription by RNA polymerase II, tRNA processing, tRNA wobble uridine modification; CC: cytoplasm, elongator holoenzyme complex, nucleoplasm, nucleus, transcription elongation factor complex
Pathways:
UniProt: Q9ER73
Entrez ID: 77766
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Thoc7
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Thoc7 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Thoc7 (THO complex 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA export from nucleus, mRNA processing, mRNA transport; MF: RNA binding, protein binding; CC: THO complex, THO complex part of transcription export complex, chromosome, telomeric region, cytoplasm, cytosol, nuclear speck, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q7TMY4
Entrez ID: 66231
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nr2c2ap
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nr2c2ap in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nr2c2ap (nuclear receptor 2C2-associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleoplasm, nucleus
Pathways:
UniProt: Q3TV70
Entrez ID: 75692
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rpl7a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rpl7a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rpl7a (ribosomal protein L7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA, ribosome biogenesis, translation at postsynapse, translation at presynapse; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P12970
Entrez ID: 27176
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lsm10
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lsm10 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lsm10 (U7 snRNP-specific Sm-like protein LSM10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle; MF: RNA binding, U7 snRNA binding, histone pre-mRNA DCP binding, snRNA binding; CC: Cajal body, U7 snRNP, cytoplasmic U snRNP body, nuclear body, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs
UniProt: Q8QZX5
Entrez ID: 116748
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Klhdc3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Klhdc3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Klhdc3 (kelch domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: chromatin binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, chromatin, cytoplasm, nucleoplasm
Pathways:
UniProt: Q8VEM9
Entrez ID: 71765
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Puf60
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Puf60 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Puf60 (poly-U binding splicing factor 60)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, apoptotic process, mRNA processing, mRNA splice site recognition, regulation of alternative mRNA splicing, via spliceosome; MF: DNA binding, RNA binding, identical protein binding, nucleic acid binding; CC: cell junction, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q3UEB3
Entrez ID: 67959
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ostc
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ostc in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ostc (oligosaccharyltransferase complex subunit (non-catalytic))
Type: protein-coding
Summary: Predicted to be involved in protein glycosylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including Meckel's cartilage; central nervous system; pancreas epithelium; retina; and skeleton. Orthologous to human OSTC (oligosaccharyltransferase complex non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: protein N-linked glycosylation via asparagine, protein glycosylation; MF: molecular_function, protein-macromolecule adaptor activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, PD-L1(CD274) glycosylation and translocation to plasma membrane, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family
UniProt: Q78XF5
Entrez ID: 66357
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lamtor4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lamtor4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lamtor4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid stimulus, positive regulation of TOR signaling, positive regulation of TORC1 signaling, protein localization to lysosome, regulation of cell size; MF: guanyl-nucleotide exchange factor activity, molecular adaptor activity; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, late endosome membrane, lysosomal membrane, lysosome
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling
UniProt: Q8CF66
Entrez ID: 66096
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mipep
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mipep in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mipep (mitochondrial intermediate peptidase)
Type: protein-coding
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in heart and tibialis anterior. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 31. Orthologous to human MIPEP (mitochondrial intermediate peptidase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: peptide metabolic process, protein processing involved in protein targeting to mitochondrion, proteolysis; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: A6H611
Entrez ID: 70478
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Kansl2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Kansl2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Kansl2 (KAT8 regulatory NSL complex subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription; CC: NSL complex, actin cytoskeleton, cytosol, histone acetyltransferase complex, mitochondrion, nucleoplasm, nucleus, plasma membrane
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q8BQR4
Entrez ID: 69612
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Bex6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Bex6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Bex6 (brain expressed family member 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromosome segregation, negative regulation of tubulin deacetylation, regulation of cell migration, regulation of cell population proliferation; MF: alpha-tubulin binding, histone deacetylase binding; CC: cytoplasm, cytosol, microtubule, nucleoplasm, nucleus, spindle pole
Pathways:
UniProt: Q3TZW7
Entrez ID: 328660
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rrp1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rrp1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rrp1 (ribosomal RNA processing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: chromosome, nucleolus, nucleus, preribosome, small subunit precursor
Pathways:
UniProt: P56183
Entrez ID: 18114
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Acat3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Acat3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Acat3 (acetyl-Coenzyme A acetyltransferase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acetyl-CoA C-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity; CC: cytoplasm, mitochondrion
Pathways: Butanoate metabolism - Mus musculus (mouse), Fat digestion and absorption - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), Glyoxylate and dicarboxylate metabolism - Mus musculus (mouse), Lysine degradation - Mus musculus (mouse), Pyruvate metabolism - Mus musculus (mouse), Terpenoid backbone biosynthesis - Mus musculus (mouse), Tryptophan metabolism - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse)
UniProt: Q80X81
Entrez ID: 224530
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rcc2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rcc2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rcc2 (regulator of chromosome condensation 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of GTPase activity, cell division, chromosome passenger complex localization to kinetochore, establishment of protein localization, focal adhesion assembly, integrin-mediated signaling pathway, negative regulation of GTPase activity, negative regulation of focal adhesion assembly, negative regulation of substrate adhesion-dependent cell spreading, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of attachment of spindle microtubules to kinetochore, regulation of cell migration, regulation of fibroblast migration, regulation of ruffle assembly; MF: guanyl-nucleotide exchange factor activity, microtubule binding, protein domain specific binding, protein kinase binding, small GTPase binding; CC: chromosome, chromosome, centromeric core domain, chromosome, centromeric region, cytoplasm, cytoskeleton, early endosome membrane, membrane, microtubule, midbody, mitotic spindle midzone, nucleolus, nucleus, plasma membrane, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8BK67
Entrez ID: 108911
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ybx1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ybx1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ybx1 (Y box protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CRD-mediated mRNA stabilization, RNA splicing, RNA transport, cellular response to interleukin-7, embryonic morphogenesis, epidermis development, in utero embryonic development, mRNA processing, mRNA stabilization, miRNA transport, negative regulation of RNA metabolic process, negative regulation of cellular senescence, negative regulation of macromolecule biosynthetic process, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, negative regulation of striated muscle cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of translation, positive regulation of cell division, positive regulation of cytoplasmic translation, positive regulation of transcription by RNA polymerase II, protein localization to cytoplasmic stress granule, regulation of DNA-templated transcription, regulation of gene expression, tRNA transport; MF: C5-methylcytidine-containing RNA reader activity, DNA binding, GTPase binding, RNA binding, chromatin binding, mRNA binding, miRNA binding, nucleic acid binding, p53 binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, single-stranded DNA binding; CC: CRD-mediated mRNA stability complex, P-body, U12-type spliceosomal complex, cytoplasm, cytoplasmic stress granule, cytosol, dendrite, endoplasmic reticulum, extracellular exosome, extracellular region, histone pre-mRNA 3'end processing complex, neuronal cell body, nucleus, perinuclear region of cytoplasm, plasma membrane, protein-containing complex, ribonucleoprotein complex, synapse
Pathways: Cytokine Signaling in Immune system, Immune System, Interferon Signaling, Interferon gamma signaling, Metabolism of RNA, NOTCH3 Activation and Transmission of Signal to the Nucleus, Noncanonical activation of NOTCH3, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH3, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P62960
Entrez ID: 22608
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rpl39
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rpl39 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rpl39 (ribosomal protein L39)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cytoplasmic translation, defense response to Gram-positive bacterium, innate immune response in mucosa, translation; MF: protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular space, ribonucleoprotein complex, ribosome
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62892
Entrez ID: 67248
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rbm19
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rbm19 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rbm19 (RNA binding motif protein 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of embryonic development, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding; CC: chromosome, cytoplasm, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8R3C6
Entrez ID: 74111
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ngdn
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ngdn in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ngdn (neuroguidin, EIF4E binding protein)
Type: protein-coding
Summary: Predicted to be involved in several processes, including maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of protein localization to plasma membrane; and regulation of translation at postsynapse. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in several cellular components, including glutamatergic synapse; nucleolus; and perforant pathway to dendrate granule cell synapse. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and cerebral cortex ventricular layer. Orthologous to human NGDN (neuroguidin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of protein localization to plasma membrane, postsynaptic modulation of chemical synaptic transmission, regulation of translation, regulation of translation at postsynapse, ribosomal small subunit biogenesis; CC: axon, cell projection, chromosome, chromosome, centromeric region, cytoplasm, dendrite, filopodium, glutamatergic synapse, mitochondrion, nucleolus, nucleoplasm, nucleus, perforant pathway to dendrate granule cell synapse, postsynapse, small-subunit processome
Pathways:
UniProt: Q9DB96
Entrez ID: 68966
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cct5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cct5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cct5 (chaperonin containing TCP1 subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, response to virus; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, G-protein beta-subunit binding, beta-tubulin binding, hydrolase activity, mRNA 3'-UTR binding, mRNA 5'-UTR binding, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, centrosome, chaperonin-containing T-complex, cytoplasm, cytoskeleton, microtubule, myelin sheath, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: P80316
Entrez ID: 12465
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dnmt1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dnmt1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dnmt1 (DNA methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a methyltransferase that preferentially methylates cytosines of CpG residues in hemimethylated DNA to generate fully methylated CpG base pairs during DNA replication. This enzyme plays roles in diverse cellular processes including cell cycle regulation, DNA repair, and telomere maintenance. The encoded protein is composed of an N-terminal domain with a nuclear localization sequence and replication fork-targeting domain, a DNA-binding CXXC domain, two bromo-adjacent homology domains, and a C-terminal catalytic domain. Mouse embryonic stem cells mutant for this gene are viable, but when introduced into the germ line, cause a recessive lethal phenotype with mutant embryos displaying stunted growth and developmental defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cellular response to amino acid stimulus, cellular response to bisphenol A, cellular response to transforming growth factor beta stimulus, chromatin organization, chromosomal DNA methylation maintenance following DNA replication, epigenetic programming of gene expression, methylation, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell apoptotic process, negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching, positive regulation of gene expression, positive regulation of vascular associated smooth muscle cell proliferation, regulation of cell population proliferation, regulation of gene expression, response to bisphenol A, response to xenobiotic stimulus; MF: DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA binding, DNA-methyltransferase activity, RNA binding, catalytic activity, chromatin binding, histone deacetylase binding, lncRNA binding, metal ion binding, methyl-CpG binding, methyltransferase activity, nuclear estrogen receptor binding, promoter-specific chromatin binding, protein binding, protein domain specific binding, transferase activity, zinc ion binding; CC: cytoplasm, female germ cell nucleus, germ cell nucleus, heterochromatin, nucleoplasm, nucleus, pericentric heterochromatin, protein-containing complex, replication fork
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), Epigenetic regulation of gene expression, Gene expression (Transcription), Metabolism of proteins, MicroRNAs in cancer - Mus musculus (mouse), PRC2 methylates histones and DNA, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA methylation proteins
UniProt: P13864
Entrez ID: 13433
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Psma7
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Psma7 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Psma7 (proteasome subunit alpha 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: identical protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gene expression (Transcription), Generic Transcription Pathway, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Huntington disease - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spinocerebellar ataxia - Mus musculus (mouse), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, Targeted protein degradation, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q9Z2U0
Entrez ID: 26444
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Morf4l2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Morf4l2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Morf4l2 (mortality factor 4 like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair; CC: NuA4 histone acetyltransferase complex, nucleolus, nucleoplasm, nucleosome, nucleus, plasma membrane
Pathways:
UniProt: Q9R0Q4
Entrez ID: 56397
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mtx2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mtx2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mtx2 (metaxin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial transport, mitochondrion organization, protein transport; CC: SAM complex, membrane, mitochondrial outer membrane, mitochondrion, nucleolus
Pathways:
UniProt: O88441
Entrez ID: 53375
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sco2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sco2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sco2 (SCO2 cytochrome c oxidase assembly protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: copper ion homeostasis, eye development, in utero embryonic development, intracellular copper ion homeostasis, mitochondrial cytochrome c oxidase assembly, muscle system process, respiratory chain complex IV assembly, respiratory electron transport chain, response to activity; MF: copper chaperone activity, copper ion binding, metal ion binding, protein-disulfide reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, myofibril
Pathways: Aerobic respiration and respiratory electron transport, Central carbon metabolism in cancer - Mus musculus (mouse), Complex IV assembly, Metabolism, Respiratory electron transport
UniProt: Q8VCL2
Entrez ID: 100126824
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Med24
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Med24 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Med24 (mediator complex subunit 24)
Type: protein-coding
Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, somatic stem cell population maintenance, transcription by RNA polymerase II; MF: histone acetyltransferase activity, nuclear thyroid hormone receptor binding, protein-containing complex binding, transcription coactivator activity, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q99K74
Entrez ID: 23989
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pisd
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pisd in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pisd (phosphatidylserine decarboxylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid droplet formation, lipid metabolic process, mitochondrial protein catabolic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process, protein autoprocessing, regulation of mitochondrion organization; MF: carboxy-lyase activity, lyase activity, phosphatidylserine decarboxylase activity; CC: Golgi apparatus, cytoplasm, cytosol, lipid droplet, membrane, mitochondrial inner membrane, mitochondrion, nucleus
Pathways: Glycerophospholipid metabolism - Mus musculus (mouse), phosphatidylethanolamine biosynthesis I, phospholipid biosynthesis I
UniProt: Q8BSF4
Entrez ID: 320951
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nmd3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nmd3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nmd3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: Predicted to enable protein-macromolecule adaptor activity and ribosomal large subunit binding activity. Predicted to be involved in positive regulation of RNA biosynthetic process; positive regulation of protein localization to nucleolus; and ribosomal large subunit export from nucleus. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human NMD3 (NMD3 ribosome export adaptor). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: positive regulation of RNA biosynthetic process, positive regulation of protein localization to nucleolus, protein transport, ribosomal large subunit export from nucleus; MF: protein-macromolecule adaptor activity, ribosomal large subunit binding; CC: cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Nucleocytoplasmic transport - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q99L48
Entrez ID: 97112
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ndufaf7
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ndufaf7 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ndufaf7 (NADH:ubiquinone oxidoreductase complex assembly factor 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, mitochondrial respiratory chain complex I assembly, peptidyl-arginine methylation, to symmetrical-dimethyl arginine; MF: enzyme binding, methyltransferase activity, protein-arginine omega-N symmetric methyltransferase activity, transferase activity; CC: mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: Q9CWG8
Entrez ID: 73694
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ndufs1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ndufs1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP synthesis coupled electron transport, aerobic respiration, cellular respiration, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, electron transfer activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, myelin sheath, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q91VD9
Entrez ID: 227197
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Dohh
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Dohh in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Dohh (deoxyhypusine hydroxylase/monooxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: deoxyhypusine monooxygenase activity, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity; CC: cellular_component, cytosol
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification
UniProt: Q99LN9
Entrez ID: 102115
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Anapc4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Anapc4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Anapc4 (anaphase promoting complex subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of mitotic metaphase/anaphase transition; MF: protein phosphatase binding; CC: anaphase-promoting complex, nuclear periphery, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q91W96
Entrez ID: 52206
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Wdr24
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Wdr24 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Wdr24 (WD repeat domain 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, autophagy, cellular response to amino acid starvation, cellular response to nutrient levels, cytoplasmic translation, negative regulation of TORC1 signaling, negative regulation of translational initiation, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of macroautophagy, positive regulation of translational initiation, protein K6-linked ubiquitination, protein localization to lysosome, protein localization to plasma membrane, protein ubiquitination, regulation of autophagy; MF: metal ion binding, molecular_function, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: GATOR2 complex, cytosol, lysosomal membrane, lysosome, membrane, vacuolar membrane
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8CFJ9
Entrez ID: 268933
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ndufaf1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ndufaf1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ndufaf1 (NADH:ubiquinone oxidoreductase complex assembly factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chaperone-mediated protein complex assembly, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CWX2
Entrez ID: 69702
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Eif2b4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Eif2b4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Eif2b4 (eukaryotic translation initiation factor 2B, subunit 4 delta)
Type: protein-coding
Summary: Predicted to enable translation initiation factor binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; nervous system development; and response to glucose. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in several structures, including adipose tissue; brain; eye; gut gland; and male reproductive gland or organ. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: T cell receptor signaling pathway, animal organ development, central nervous system development, cytoplasmic translational initiation, myelination, oligodendrocyte development, ovarian follicle development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of proteins, Recycling of eIF2:GDP, Translation
UniProt: Q61749
Entrez ID: 13667
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Urod
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Urod in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Urod (uroporphyrinogen decarboxylase)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the conversion of uroporphyrinogen-III to coproporphyrinogen-III, an intermediate step in heme biosynthesis. Homozygous knockout mice for this gene exhibit embryonic lethality. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: cell population proliferation, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, heme metabolic process, porphyrin-containing compound biosynthetic process, porphyrin-containing compound catabolic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process, uroporphyrinogen III metabolic process; MF: carboxy-lyase activity, ferrous iron binding, lyase activity, uroporphyrinogen decarboxylase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Heme biosynthesis, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, heme biosynthesis from uroporphyrinogen-III I
UniProt: P70697
Entrez ID: 22275
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl17
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl17 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl17 (mitochondrial ribosomal protein L17)
Type: protein-coding
Summary: Predicted to enable protein domain specific binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrial inner membrane. Is expressed in several structures, including early conceptus; gonad; skeleton; submandibular gland primordium; and thymus primordium. Orthologous to human MRPL17 (mitochondrial ribosomal protein L17). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, mitochondrion organization, translation; MF: protein domain specific binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D8P4
Entrez ID: 27397
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pars2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pars2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pars2 (prolyl-tRNA synthetase (mitochondrial)(putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: prolyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, proline-tRNA ligase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8CFI5
Entrez ID: 230577
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ilf3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ilf3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ilf3 (interleukin enhancer binding factor 3)
Type: protein-coding
Summary: The protein encoded by this gene contains two double-stranded RNA binding domains and functions in the post-transcriptional regulation of gene expression. It is a component of an RNA-protein complex that may be involved in mediating the export of messenger RNAs. Alternative splicing results in multiple transcript variants encoding distinct isoforms. These isoforms are grouped into two categories, NFAR-1 or NFAR-2, based on variation at the C-terminus. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: defense response to virus, negative regulation of DNA-templated transcription, negative regulation of translation, negative regulation of viral genome replication, positive regulation of DNA-templated transcription, protein phosphorylation, spliceosome-depend formation of circular RNA, symbiont entry into host cell; MF: DNA binding, RNA binding, double-stranded RNA binding, enzyme binding, mRNA 3'-UTR AU-rich region binding, single-stranded RNA binding, virus receptor activity; CC: cytoplasm, mitochondrion, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Adherens junctions interactions, Antiviral mechanism by IFN-stimulated genes, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cytokine Signaling in Immune system, Immune System, Interferon Signaling, PKR-mediated signaling, Regulation of CDH11 Expression and Function, Regulation of CDH11 gene transcription, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q9Z1X4
Entrez ID: 16201
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrps16
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrps16 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrps16 (mitochondrial ribosomal protein S16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: cytosol, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CPX7
Entrez ID: 66242
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SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
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mouse
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knockout
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Coq6
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NG2-3112 mouse glioblastoma cells
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decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
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difficult
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Does knockout of Coq6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
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Gene: Coq6 (coenzyme Q6 monooxygenase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ubiquinone biosynthetic process; MF: 2-methoxy-6-polyprenolphenol 4-hydroxylase activity, 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity, FAD binding, flavin adenine dinucleotide binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: Golgi apparatus, cell projection, extrinsic component of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion, ubiquinone biosynthesis complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Ubiquinol biosynthesis, Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse)
UniProt: Q8R1S0
Entrez ID: 217707
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SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
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knockout
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Usp22
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NG2-3112 mouse glioblastoma cells
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decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Usp22 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
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Gene: Usp22 (ubiquitin specific peptidase 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, chromatin organization, chromatin remodeling, positive regulation of DNA-templated transcription, positive regulation of mitotic cell cycle, positive regulation of type I interferon production, protein deubiquitination, proteolysis, regulation of DNA repair, regulation of RNA splicing, regulation of transcription by RNA polymerase II, ubiquitin-dependent protein catabolic process; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, enzyme binding, histone H2A deubiquitinase activity, histone H2B deubiquitinase activity, histone H4 acetyltransferase activity, hydrolase activity, metal ion binding, peptidase activity, transcription coactivator activity, zinc ion binding; CC: SAGA complex, cytoplasm, nucleus, transcription factor TFTC complex
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q5DU02
Entrez ID: 216825
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