screen_file
string | organism
string | perturbation
string | gene
string | cell
string | phenotype
string | hit
int64 | benchmark_type
string | prompt
string | gene_context
string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Polr3f
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Polr3f in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Polr3f (polymerase (RNA) III (DNA directed) polypeptide F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production, transcription by RNA polymerase III; MF: 4 iron, 4 sulfur cluster binding, double-stranded DNA binding, iron-sulfur cluster binding, metal ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, cytoplasm, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q921X6
Entrez ID: 70408
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ppan
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ppan in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ppan (peter pan homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of cell growth by extracellular stimulus; MF: rRNA binding; CC: nucleolus, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q91YU8
Entrez ID: 235036
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Alyref
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Alyref in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Alyref (Aly/REF export factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, RNA folding, RNA splicing, mRNA export from nucleus, mRNA processing, mRNA transport; MF: C5-methylcytidine-containing RNA reader activity, RNA binding, RNA folding chaperone, mRNA binding, molecular adaptor activity, nucleic acid binding, single-stranded DNA binding; CC: catalytic step 2 spliceosome, chromosome, telomeric region, cytoplasm, exon-exon junction complex, nuclear speck, nucleus, spliceosomal complex, transcription export complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: O08583
Entrez ID: 21681
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nup62
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nup62 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nup62 (nucleoporin 62)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA export from nucleus, cell migration, cell surface receptor signaling pathway, cellular senescence, centriole assembly, centrosome cycle, mRNA transport, mitotic centrosome separation, mitotic metaphase chromosome alignment, negative regulation of MAP kinase activity, negative regulation of Ras protein signal transduction, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of programmed cell death, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of centriole replication, positive regulation of mitotic cytokinetic process, positive regulation of mitotic nuclear division, positive regulation of protein localization to centrosome, protein import into nucleus, protein transport, regulation of mitotic spindle organization, regulation of protein import into nucleus; MF: Hsp70 protein binding, Hsp90 protein binding, PTB domain binding, SH2 domain binding, kinesin binding, nuclear thyroid hormone receptor binding, phospholipid binding, protein binding, protein-containing complex binding, signaling receptor complex adaptor activity, structural constituent of nuclear pore, ubiquitin binding; CC: Flemming body, annulate lamellae, centrosome, cytoplasm, cytoskeleton, mitotic spindle, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore central transport channel, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, spindle pole
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: Q63850
Entrez ID: 18226
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl52
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl52 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl52 (mitochondrial ribosomal protein L52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9D0Y8
Entrez ID: 68836
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Wdr82
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Wdr82 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Wdr82 (WD repeat domain containing 82)
Type: protein-coding
Summary: Enables chromatin binding activity and lncRNA binding activity. Involved in RNA catabolic process and negative regulation of DNA-templated transcription. Acts upstream of or within gene expression. Located in nucleus. Is expressed in early conceptus and ovary. Orthologous to human WDR82 (WD repeat domain 82). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription termination, RNA polymerase II promoter clearance, gene expression, lncRNA catabolic process, negative regulation of DNA-templated transcription, elongation, negative regulation of lncRNA transcription, nuclear RNA surveillance, positive regulation of transcription elongation by RNA polymerase II; MF: chromatin binding, lncRNA binding, protein binding; CC: PTW/PP1 phosphatase complex, Set1C/COMPASS complex, chromatin, chromosome, chromosome, telomeric region, cytoplasm, histone methyltransferase complex, nucleolus, nucleus
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Metabolism of RNA, Nuclear RNA decay, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8BFQ4
Entrez ID: 77305
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rps12
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rps12 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rps12 (ribosomal protein S12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maintenance of translational fidelity, positive regulation of canonical Wnt signaling pathway, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: Golgi apparatus, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63323
Entrez ID: 20042
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Abca2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Abca2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Abca2 (ATP-binding cassette, sub-family A member 2)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; ceramide floppase activity; and endopeptidase regulator activity. Involved in several processes, including regulation of intracellular cholesterol transport; regulation of protein localization; and sphingolipid metabolic process. Acts upstream of or within central nervous system myelin formation. Located in lysosomal membrane. Is expressed in brain; retina; and spinal cord. Orthologous to human ABCA2 (ATP binding cassette subfamily A member 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: central nervous system myelin formation, ceramide translocation, cholesterol homeostasis, ganglioside metabolic process, glycosphingolipid metabolic process, intracellular sphingolipid homeostasis, lipid transport, locomotory behavior, negative regulation of cholesterol efflux, negative regulation of intracellular cholesterol transport, negative regulation of phospholipid biosynthetic process, negative regulation of receptor-mediated endocytosis involved in cholesterol transport, negative regulation of sphingolipid biosynthetic process, negative regulation of steroid metabolic process, positive regulation of amyloid precursor protein biosynthetic process, positive regulation of amyloid precursor protein catabolic process, positive regulation of amyloid-beta formation, positive regulation of low-density lipoprotein particle receptor catabolic process, positive regulation of protein metabolic process, regulation of glycoprotein biosynthetic process, regulation of intracellular cholesterol transport, regulation of post-translational protein modification, regulation of protein localization to cell periphery, regulation of protein localization to cell surface, regulation of steroid metabolic process, response to steroid hormone, sphingomyelin metabolic process, sphingosine biosynthetic process, transmembrane transport; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, ceramide floppase activity, endopeptidase regulator activity, lipid transporter activity, nucleotide binding; CC: cytoplasmic vesicle, endosome, endosome membrane, intracellular membrane-bounded organelle, lysosomal membrane, lysosome, membrane, microtubule organizing center, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), Lysosome - Mus musculus (mouse)
UniProt: A2AJ26
Entrez ID: 11305
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nek8
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nek8 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nek8 (NIMA (never in mitosis gene a)-related expressed kinase 8)
Type: protein-coding
Summary: This gene encodes a NIMA-related kinase. Members of this serine/threonine protein kinase family are structurally-related to NIMA (never in mitosis, gene A) which controls mitotic signaling in Aspergillus nidulans. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: animal organ development, animal organ morphogenesis, determination of left/right symmetry, heart development, regulation of hippo signaling; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, centrosome, ciliary base, ciliary inversin compartment, cilium, cytoplasm, cytoskeleton
Pathways:
UniProt: Q91ZR4
Entrez ID: 140859
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
R3hdm1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of R3hdm1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: R3hdm1 (R3H domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, nucleic acid binding
Pathways:
UniProt: E9Q9Q2, Q80ZH9, B9EHE8, Q3URW7, A0A087WPF0, A0A087WQI5, A0A087WQF6, A0A087WRE1, A0A087WP65
Entrez ID: 226412
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Fars2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Fars2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Fars2 (phenylalanine-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: Predicted to enable phenylalanine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and tRNA processing. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: phenylalanyl-tRNA aminoacylation, tRNA aminoacylation, tRNA processing, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, phenylalanine-tRNA ligase activity, tRNA binding; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q99M01
Entrez ID: 69955
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ppp1r8
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ppp1r8 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ppp1r8 (protein phosphatase 1, regulatory subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, cell population proliferation, mRNA processing; MF: DNA binding, RNA binding, RNA endonuclease activity, mRNA binding, molecular function inhibitor activity, protein binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, protein serine/threonine phosphatase inhibitor activity; CC: nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways:
UniProt: Q8R3G1
Entrez ID: 100336
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Alas1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Alas1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Alas1 (aminolevulinic acid synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to insulin stimulus, erythrocyte development, heme A biosynthetic process, heme B biosynthetic process, heme biosynthetic process, hemoglobin biosynthetic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process, response to bile acid, response to cAMP, response to cobalt ion, response to ethanol, response to gonadotropin, response to herbicide, response to hypoxia, response to nickel cation, response to nutrient levels, response to platinum ion, response to xenobiotic stimulus, tetrapyrrole biosynthetic process; MF: 5-aminolevulinate synthase activity, acyltransferase activity, identical protein binding, pyridoxal phosphate binding, transferase activity; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: Glycine, serine and threonine metabolism - Mus musculus (mouse), Heme biosynthesis, Metabolism, Metabolism of porphyrins, Metabolism of proteins, Mitochondrial protein degradation, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme biosynthesis II, tetrapyrrole biosynthesis II
UniProt: Q8VC19
Entrez ID: 11655
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cct8
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cct8 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cct8 (chaperonin containing TCP1 subunit 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, cell projection, centrosome, chaperonin-containing T-complex, cilium, cytoplasm, cytoskeleton, microtubule, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Protein folding
UniProt: P42932
Entrez ID: 12469
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mapkap1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mapkap1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mapkap1 (mitogen-activated protein kinase associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC2 signaling, cellular response to insulin stimulus, cellular response to nutrient levels, cytoskeleton organization, insulin receptor signaling pathway, negative regulation of Ras protein signal transduction, negative regulation of apoptotic process, negative regulation of insulin receptor signaling pathway, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of cell growth, positive regulation of peptidyl-serine phosphorylation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of cellular response to oxidative stress, ubiquitin-dependent protein catabolic process; MF: enzyme-substrate adaptor activity, molecular adaptor activity, phosphatidic acid binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein kinase binding, small GTPase binding; CC: Golgi apparatus, Golgi membrane, TORC2 complex, cilium, cytoplasm, cytosol, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, mitochondrial outer membrane, mitochondrion, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, serine/threonine protein kinase complex
Pathways: Adaptive Immune System, CD28 dependent PI3K/Akt signaling, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Co-stimulation by CD28, Gene expression (Transcription), Generic Transcription Pathway, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Intracellular signaling by second messengers, PIP3 activates AKT signaling, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Transcriptional Regulation by TP53, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8BKH7
Entrez ID: 227743
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Phf21a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Phf21a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Phf21a (PHD finger protein 21A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of transcription by RNA polymerase II, suckling behavior; MF: DNA binding, chromatin binding, metal ion binding, zinc ion binding; CC: DNA repair complex, histone deacetylase complex, male germ cell nucleus, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Factors involved in megakaryocyte development and platelet production, HDACs deacetylate histones, Hemostasis
UniProt: Q6ZPK0
Entrez ID: 192285
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Timm9
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Timm9 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Timm9 (translocase of inner mitochondrial membrane 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein transport; MF: membrane insertase activity, metal ion binding, protein homodimerization activity, protein transporter activity, protein-folding chaperone binding; CC: TIM22 mitochondrial import inner membrane insertion complex, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial intermembrane space chaperone complex, mitochondrion
Pathways:
UniProt: Q9WV98
Entrez ID: 30056
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Smc1a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Smc1a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Smc1a (structural maintenance of chromosomes 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cell division, chromosome organization, meiotic cell cycle, mitotic spindle assembly, response to DNA damage checkpoint signaling, response to radiation, sister chromatid cohesion, somatic stem cell population maintenance; MF: ATP binding, ATP hydrolysis activity, DNA binding, chromatin binding, mediator complex binding, nucleotide binding, protein binding, protein heterodimerization activity; CC: chromosome, chromosome, centromeric region, cohesin complex, cytosol, kinetochore, lateral element, meiotic cohesin complex, mitotic cohesin complex, mitotic spindle pole, nuclear matrix, nucleoplasm, nucleus, synaptonemal complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cohesin Loading onto Chromatin, Establishment of Sister Chromatid Cohesion, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Telophase/Cytokinesis, Oocyte meiosis - Mus musculus (mouse), Post-translational protein modification, Resolution of Sister Chromatid Cohesion, S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, Separation of Sister Chromatids
UniProt: Q9CU62
Entrez ID: 24061
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Sf3b6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Sf3b6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Sf3b6 (splicing factor 3B, subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst formation, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding; CC: U12-type spliceosomal complex, U2-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Spliceosome - Mus musculus (mouse)
UniProt: P59708
Entrez ID: 66055
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nutf2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nutf2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nutf2 (nuclear transport factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA transport, negative regulation of vascular endothelial growth factor production, nucleocytoplasmic transport, positive regulation of protein import into nucleus, protein export from nucleus, protein import into nucleus, protein localization to nuclear pore, protein transport; MF: identical protein binding, nuclear import signal receptor activity, small GTPase binding; CC: cytoplasm, cytosol, membrane, nuclear inner membrane, nuclear membrane, nuclear outer membrane, nuclear pore, nuclear pore central transport channel, nucleoplasm, nucleus
Pathways:
UniProt: P61971
Entrez ID: 68051
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Eif4ebp3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Eif4ebp3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Eif4ebp3 (eukaryotic translation initiation factor 4E binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of translation, negative regulation of translational initiation, regulation of translation; MF: eukaryotic initiation factor 4E binding, translation repressor activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q80VV3
Entrez ID: 108112
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Glrx5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Glrx5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Glrx5 (glutaredoxin 5)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in the human gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: [2Fe-2S] cluster assembly, hemopoiesis, protein maturation; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding; CC: dendrite, iron-sulfur cluster assembly complex, mitochondrial matrix, mitochondrion, neuronal cell body
Pathways: Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q80Y14
Entrez ID: 73046
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nhp2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nhp2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nhp2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis, snoRNA guided rRNA pseudouridine synthesis, telomere maintenance via telomerase; MF: RNA binding, U3 snoRNA binding, box H/ACA snoRNA binding, mRNA 3'-UTR binding, protein binding, telomerase RNA binding; CC: Cajal body, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, nucleolus, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q9CRB2
Entrez ID: 52530
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rsl24d1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rsl24d1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rsl24d1 (ribosomal L24 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosome - Mus musculus (mouse)
UniProt: Q99L28
Entrez ID: 225215
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Psmg4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Psmg4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Psmg4 (proteasome (prosome, macropain) assembly chaperone 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, proteasome assembly; MF: molecular_function, protein binding, protein-containing complex binding; CC: cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Proteasome assembly
UniProt: P0C7N9
Entrez ID: 69666
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Atg9a
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Atg9a in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Atg9a (autophagy related 9A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagy, bone morphogenesis, innate immune response, lipid transport, mitophagy, negative regulation of interferon-beta production, negative regulation of macrophage cytokine production, piecemeal microautophagy of the nucleus, plasma membrane phospholipid scrambling, programmed necrotic cell death, protein localization to Golgi apparatus, protein localization to phagophore assembly site, reticulophagy; MF: phospholipid scramblase activity; CC: Golgi apparatus, Golgi membrane, autophagosome, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, late endosome, late endosome membrane, membrane, mitochondrial membrane, mitochondrion, phagophore assembly site, phagophore assembly site membrane, recycling endosome, recycling endosome membrane, synaptic membrane, synaptic vesicle, trans-Golgi network
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), Macroautophagy, Mitophagy, Mitophagy - animal - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, Selective autophagy
UniProt: Q68FE2
Entrez ID: 245860
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Seh1l
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Seh1l in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Seh1l (SEH1-like (S. cerevisiae)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cell division, cellular response to amino acid starvation, cellular response to nutrient levels, chromosome segregation, defense response to Gram-positive bacterium, mRNA transport, mitotic metaphase chromosome alignment, nuclear pore organization, nucleocytoplasmic transport, positive regulation of TORC1 signaling, protein transport, protein-containing complex localization; CC: GATOR2 complex, Seh1-associated complex, chromosome, chromosome, centromeric region, kinetochore, lysosomal membrane, lysosome, membrane, nuclear envelope, nuclear pore, nuclear pore outer ring, nucleus
Pathways: Amino acids regulate mTORC1, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mTOR signaling pathway - Mus musculus (mouse), snRNP Assembly
UniProt: Q8R2U0
Entrez ID: 72124
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Caap1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Caap1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Caap1 (caspase activity and apoptosis inhibitor 1)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of apoptotic process. Orthologous to human CAAP1 (caspase activity and apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, regulation of apoptotic process
Pathways:
UniProt: Q8VDY9
Entrez ID: 67770
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Supt20
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Supt20 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Supt20 (SPT20 SAGA complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gastrulation, positive regulation of DNA-templated transcription, positive regulation of gluconeogenesis, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of RNA splicing, regulation of transcription by RNA polymerase II; MF: transcription coregulator activity; CC: SAGA complex, SAGA-type complex
Pathways: Autophagy - animal - Mus musculus (mouse)
UniProt: Q7TT00
Entrez ID: 56790
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Plekhh3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Plekhh3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Plekhh3 (pleckstrin homology domain containing, family H (with MyTH4 domain) member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8VCE9
Entrez ID: 217198
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pdss2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pdss2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pdss2 (prenyl (solanesyl) diphosphate synthase, subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellum development, isoprenoid biosynthetic process, lipid metabolic process, regulation of body fluid levels, ubiquinone biosynthetic process; MF: all-trans-decaprenyl-diphosphate synthase activity, all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity, prenyltransferase activity, protein binding, protein heterodimerization activity, transferase activity; CC: cytosol, heterotetrameric polyprenyl diphosphate synthase complex, mitochondrion, polyprenyl diphosphate synthase complex, transferase complex, ubiquinone biosynthesis complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Terpenoid backbone biosynthesis - Mus musculus (mouse), Ubiquinol biosynthesis, nonaprenyl diphosphate biosynthesis I
UniProt: Q33DR3
Entrez ID: 71365
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl14
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl14 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl14 (mitochondrial ribosomal protein L14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9D1I6
Entrez ID: 68463
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ddx54
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ddx54 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ddx54 (DEAD box helicase 54)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA metabolic process, RNA processing, negative regulation of DNA-templated transcription, rRNA processing; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nuclear estrogen receptor binding, nucleic acid binding, nucleotide binding, signaling receptor binding, transcription corepressor activity; CC: Golgi apparatus, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8K4L0
Entrez ID: 71990
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Eif3e
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Eif3e in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Eif3e (eukaryotic translation initiation factor 3, subunit E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of translation, translation, translational initiation; MF: translation initiation factor activity, transmembrane transporter binding; CC: PML body, cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3e, nucleus, postsynaptic density
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Hepatitis C - Mus musculus (mouse), L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: P60229
Entrez ID: 16341
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Wdr75
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Wdr75 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Wdr75 (WD repeat domain 75)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in pancreas epithelium. Orthologous to human WDR75 (WD repeat domain 75). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding; CC: nucleolus, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q3U821
Entrez ID: 73674
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nol6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nol6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nol6 (nucleolar protein family 6 (RNA-associated))
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be involved in rRNA processing; ribosomal small subunit biogenesis; and tRNA export from nucleus. Located in condensed nuclear chromosome and nucleolus. Is expressed in several structures, including cerebral cortex; gut; liver; spleen; and testis. Orthologous to human NOL6 (nucleolar protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, tRNA export from nucleus; CC: CURI complex, UTP-C complex, chromosome, condensed nuclear chromosome, mitochondrion, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8R5K4
Entrez ID: 230082
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nol12
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nol12 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nol12 (nucleolar protein 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, identical protein binding, rRNA binding, single-stranded DNA binding; CC: cytoplasm, nucleolus, nucleus
Pathways:
UniProt: Q8BG17
Entrez ID: 97961
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Slc38a2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Slc38a2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Slc38a2 (solute carrier family 38, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-glutamine import across plasma membrane, L-proline import across plasma membrane, L-serine import across plasma membrane, L-serine transport, acidic amino acid transport, alanine transport, amino acid import, amino acid transmembrane transport, amino acid transport, cellular response to amino acid starvation, cellular response to arsenite(3-), cellular response to mechanical stimulus, cerebral cortex development, female pregnancy, glutamine transport, glycine betaine transport, monoatomic ion transport, neutral amino acid transport, positive regulation of RNA splicing, positive regulation of gene expression, proline transport, regulation of cellular response to stress, regulation of glutamate secretion, neurotransmission, response to muscle activity, sodium ion transmembrane transport, sodium ion transport; MF: L-glutamine transmembrane transporter activity, L-serine transmembrane transporter activity, acidic amino acid transmembrane transporter activity, alanine:sodium symporter activity, amino acid transmembrane transporter activity, amino acid:sodium symporter activity, neutral L-amino acid transmembrane transporter activity, neutral L-amino acid:sodium symporter activity, proline:sodium symporter activity, symporter activity; CC: axon, brush border, cytoplasm, dendrite, membrane, neuronal cell body, plasma membrane, sarcolemma
Pathways: Amino acid transport across the plasma membrane, GABAergic synapse - Mus musculus (mouse), Glutamate Neurotransmitter Release Cycle, Glutamatergic synapse - Mus musculus (mouse), Neuronal System, Neurotransmitter release cycle, Protein digestion and absorption - Mus musculus (mouse), SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Transmission across Chemical Synapses, Transport of small molecules
UniProt: Q8CFE6
Entrez ID: 67760
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pop7
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pop7 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pop7 (processing of precursor 7, ribonuclease P family, (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: nucleic acid binding, ribonuclease P RNA binding, ribonuclease P activity; CC: cytoplasm, multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleus, ribonuclease MRP complex
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9DCH2
Entrez ID: 74097
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mcrs1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mcrs1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mcrs1 (microspherule protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin organization, chromatin remodeling, negative regulation of telomere maintenance via telomere lengthening, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleolus, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, regulation of telomere maintenance, telomere maintenance; MF: G-quadruplex RNA binding, poly(G) binding, poly(U) RNA binding, telomerase inhibitor activity; CC: Ino80 complex, MLL1 complex, NSL complex, centriolar satellite, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, dendrite, histone acetyltransferase complex, kinetochore, lysosome, nuclear body, nucleolus, nucleoplasm, nucleus, perikaryon, spindle pole
Pathways: Chromatin modifying enzymes, Chromatin organization, DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Global Genome Nucleotide Excision Repair (GG-NER), HATs acetylate histones, Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q99L90
Entrez ID: 51812
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rai1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rai1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rai1 (retinoic acid induced 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: circadian regulation of gene expression, negative regulation of multicellular organism growth, positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, rhythmic process, skeletal system development; MF: metal ion binding, zinc ion binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: Q61818
Entrez ID: 19377
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Hnrnpl
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Hnrnpl in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Hnrnpl (heterogeneous nuclear ribonucleoprotein L)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to amino acid starvation, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of mRNA splicing, via spliceosome, positive regulation of translation, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA 3'-UTR binding, mRNA CDS binding, mRNA binding, nucleic acid binding, pre-mRNA intronic binding, protein binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm, pronucleus, ribonucleoprotein complex, ribonucleoprotein granule, synapse
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8R081
Entrez ID: 15388
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Get4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Get4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Get4 (golgi to ER traffic protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, maintenance of unfolded protein, post-translational protein targeting to endoplasmic reticulum membrane, protein insertion into ER membrane, regulation of protein stability, tail-anchored membrane protein insertion into ER membrane, ubiquitin-dependent protein catabolic process; MF: protein carrier chaperone, protein-folding chaperone binding; CC: BAT3 complex, chromosome, cytoplasm, cytosol, nucleolus, nucleoplasm
Pathways:
UniProt: Q9D1H7
Entrez ID: 67604
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Bptf
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Bptf in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Bptf (bromodomain PHD finger transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior/posterior pattern specification, brain development, cellular response to nerve growth factor stimulus, chromatin organization, chromatin remodeling, embryonic placenta development, endoderm development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: ATP-dependent activity, acting on DNA, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding; CC: ATPase complex, NURF complex, cell body, chromatin, dendrite, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q6P9L3, E9Q6A7, A2A654, A2A652, A0A140LHY5, A2A653, A2A655
Entrez ID: 207165
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nup43
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nup43 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nup43 (nucleoporin 43)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromosome segregation, mRNA transport, nucleocytoplasmic transport, protein transport; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, nuclear envelope, nuclear pore, nuclear pore outer ring, nuclear speck, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Mus musculus (mouse), Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, EML4 and NUDC in mitotic spindle formation, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, Inositol phosphate metabolism, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, snRNP Assembly
UniProt: P59235
Entrez ID: 69912
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Zdhhc16
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Zdhhc16 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Zdhhc16 (zinc finger, DHHC domain containing 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, apoptotic process, eye development, fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment, heart development, protein palmitoylation, telencephalon development; MF: acyltransferase activity, palmitoyltransferase activity, protein binding, protein-cysteine S-palmitoyltransferase activity, transferase activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9ESG8
Entrez ID: 74168
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Fgfr1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Fgfr1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Fgfr1 (fibroblast growth factor receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, auditory receptor cell development, biomineral tissue development, blood vessel morphogenesis, brain development, branching involved in salivary gland morphogenesis, calcium ion homeostasis, cell maturation, cell projection assembly, cellular response to fibroblast growth factor stimulus, cementum mineralization, central nervous system neuron development, chondrocyte differentiation, diphosphate metabolic process, ear development, embryonic limb morphogenesis, epidermis development, epithelial cell differentiation, epithelial to mesenchymal transition, fibroblast growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development, forebrain generation of neurons, gene expression, generation of neurons, in utero embryonic development, inner ear morphogenesis, lung development, lung-associated mesenchyme development, mesenchymal cell differentiation, midbrain development, middle ear morphogenesis, negative regulation of fibroblast growth factor production, negative regulation of gene expression, negative regulation of macromolecule biosynthetic process, negative regulation of osteoblast differentiation, negative regulation of transcription by RNA polymerase II, neuroblast proliferation, neuron projection development, orbitofrontal cortex development, organ induction, outer ear morphogenesis, paraxial mesoderm development, positive regulation of MAPK cascade, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of blood vessel endothelial cell migration, positive regulation of cardiac muscle cell proliferation, positive regulation of cell communication, positive regulation of cell cycle, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of endothelial cell chemotaxis, positive regulation of fibroblast migration, positive regulation of hepatic stellate cell activation, positive regulation of macromolecule metabolic process, positive regulation of mesenchymal cell proliferation, positive regulation of mitotic cell cycle DNA replication, positive regulation of neuron differentiation, positive regulation of neuron projection development, positive regulation of parathyroid hormone secretion, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of signaling, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial cell proliferation, postnatal olfactory bulb interneuron migration, protein autophosphorylation, regulation of apoptotic process, regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling, regulation of cell cycle process, regulation of cell population proliferation, regulation of epithelial cell proliferation, regulation of extrinsic apoptotic signaling pathway in absence of ligand, regulation of gene expression, regulation of lateral mesodermal cell fate specification, regulation of mitotic cell cycle, regulation of phosphate transport, regulation of phosphorus metabolic process, regulation of postsynaptic density assembly, regulation of primary metabolic process, regulation of stem cell proliferation, response to sodium phosphate, salivary gland morphogenesis, sensory perception of sound, stem cell differentiation, stem cell population maintenance, tangential migration from the subventricular zone to the olfactory bulb, ureteric bud development, vasculogenesis involved in coronary vascular morphogenesis, ventricular zone neuroblast division, vitamin D3 metabolic process; MF: ATP binding, SH2 domain binding, cell adhesion molecule binding, fibroblast growth factor binding, fibroblast growth factor receptor activity, heparin binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein tyrosine kinase activity, protein-containing complex binding, receptor-receptor interaction, signaling receptor binding, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, glutamatergic synapse, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynapse, receptor complex
Pathways: Adherens junction - Mus musculus (mouse), Axon guidance, Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Developmental Biology, Downstream signaling of activated FGFR1, FGFR1 ligand binding and activation, FGFR1b ligand binding and activation, FGFR1c and Klotho ligand binding and activation, FGFR1c ligand binding and activation, FRS-mediated FGFR1 signaling, IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, L1CAM interactions, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Negative regulation of FGFR1 signaling, Negative regulation of the PI3K/AKT network, Nervous system development, PI-3K cascade:FGFR1, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade: FGFR1, Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR1, Signal Transduction, Signal transduction by L1, Signaling by FGFR, Signaling by FGFR1, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse)
UniProt: P16092
Entrez ID: 14182
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lrrc69
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lrrc69 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lrrc69 (leucine rich repeat containing 69)
Type: protein-coding
Summary: Predicted to be involved in intracellular signal transduction. Orthologous to human LRRC69 (leucine rich repeat containing 69). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q9D9Q0
Entrez ID: 73314
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Imp4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Imp4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Imp4 (IMP4, U3 small nucleolar ribonucleoprotein)
Type: protein-coding
Summary: Predicted to enable snoRNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit biogenesis. Predicted to be located in fibrillar center. Predicted to be part of Mpp10 complex and small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including axial musculature; extraembryonic component; submandibular gland primordium; thymus primordium; and vibrissa. Orthologous to human IMP4 (IMP U3 small nucleolar ribonucleoprotein 4). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: rRNA binding, rRNA primary transcript binding, snoRNA binding; CC: Mpp10 complex, fibrillar center, nucleolus, nucleoplasm, nucleus, preribosome, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8VHZ7
Entrez ID: 27993
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Wdr73
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Wdr73 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Wdr73 (WD repeat domain 73)
Type: protein-coding
Summary: Predicted to be involved in cytoplasmic microtubule organization; negative regulation of apoptotic process; and nucleus organization. Predicted to colocalize with cleavage furrow; cytosol; and spindle pole. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 1. Orthologous to human WDR73 (WD repeat domain 73). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cytoplasmic microtubule organization, nucleus organization; MF: molecular_function, protein-macromolecule adaptor activity; CC: cleavage furrow, cytoplasm, cytoskeleton, cytosol, spindle, spindle pole
Pathways:
UniProt: Q9CWR1
Entrez ID: 71968
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Xrn2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Xrn2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Xrn2 (5'-3' exoribonuclease 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA recombination, DNA repair, DNA-templated transcription termination, RNA metabolic process, hippocampus development, mRNA processing, microtubule-based process, neuron differentiation, nuclear-transcribed mRNA catabolic process, nucleobase-containing compound metabolic process, retina development in camera-type eye, spermatogenesis, termination of RNA polymerase II transcription; MF: 3'-5'-RNA exonuclease activity, 5'-3' RNA exonuclease activity, 5'-3' exonuclease activity, DNA binding, RNA binding, exonuclease activity, hydrolase activity, identical protein binding, metal ion binding, nuclease activity, nucleic acid binding, protein binding, transcription termination site sequence-specific DNA binding, zinc ion binding; CC: aggresome, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, RNA degradation - Mus musculus (mouse), Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DBR1
Entrez ID: 24128
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Surf6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Surf6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Surf6 (surfeit gene 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosomal small subunit biogenesis, ribosome assembly, ribosome biogenesis; MF: DNA binding, RNA binding, molecular condensate scaffold activity; CC: chromosome, granular component, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: P70279
Entrez ID: 20935
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Itgb1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Itgb1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Itgb1 (integrin beta 1 (fibronectin receptor beta))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD40 signaling pathway, G1/S transition of mitotic cell cycle, angiogenesis, axon extension, basement membrane organization, bicellular tight junction assembly, calcium-independent cell-matrix adhesion, cardiac cell fate specification, cardiac muscle cell differentiation, cardiac muscle cell myoblast differentiation, cardiac muscle tissue development, cell adhesion, cell adhesion mediated by integrin, cell migration, cell migration involved in sprouting angiogenesis, cell projection organization, cell-cell adhesion, cell-cell adhesion mediated by integrin, cell-matrix adhesion, cell-substrate adhesion, cellular response to low-density lipoprotein particle stimulus, central nervous system neuron differentiation, dendrite morphogenesis, endocytosis, establishment of mitotic spindle orientation, fibroblast migration, formation of radial glial scaffolds, germ cell migration, heterotypic cell-cell adhesion, in utero embryonic development, integrin-mediated signaling pathway, lamellipodium assembly, leukocyte cell-cell adhesion, leukocyte tethering or rolling, maintenance of postsynaptic specialization structure, mesodermal cell differentiation, modulation of chemical synaptic transmission, muscle organ development, myoblast differentiation, myoblast fate specification, myoblast fusion, negative regulation of Rho protein signal transduction, negative regulation of anoikis, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of cell population proliferation, negative regulation of cell projection organization, negative regulation of neuron differentiation, negative regulation of vasoconstriction, neuron projection development, phagocytosis, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of cell-substrate adhesion, positive regulation of developmental process, positive regulation of endocytosis, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of fibroblast migration, positive regulation of glutamate uptake involved in transmission of nerve impulse, positive regulation of neuroblast proliferation, positive regulation of neuron differentiation, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to plasma membrane, positive regulation of vascular endothelial growth factor signaling pathway, positive regulation of wound healing, protein transport within lipid bilayer, reactive gliosis, receptor internalization, regulation of G protein-coupled receptor signaling pathway, regulation of biological quality, regulation of cell cycle, regulation of cell population proliferation, regulation of collagen catabolic process, regulation of neurotransmitter uptake, regulation of postsynaptic neurotransmitter receptor diffusion trapping, regulation of spontaneous synaptic transmission, regulation of synapse pruning, response to activity, response to muscle activity, response to radiation, sarcomere organization, stress fiber assembly, tissue development, tissue homeostasis, transforming growth factor beta receptor signaling pathway, visual learning; MF: C-X3-C chemokine binding, actin binding, alpha-actinin binding, calcium ion binding, cell adhesion molecule binding, collagen binding, collagen binding involved in cell-matrix adhesion, fibronectin binding, integrin binding, integrin binding involved in cell-matrix adhesion, kinase binding, laminin binding, magnesium ion binding, metal ion binding, protease binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein kinase binding, protein tyrosine kinase binding, protein-containing complex binding, signaling receptor activity, signaling receptor binding; CC: Schaffer collateral - CA1 synapse, acrosomal vesicle, adherens junction, anchoring junction, basement membrane, cell projection, cell surface, cell-cell junction, cerebellar climbing fiber to Purkinje cell synapse, cytoplasm, cytoplasmic vesicle, dendritic spine, endosome, external side of plasma membrane, filopodium, focal adhesion, glial cell projection, glutamatergic synapse, glycinergic synapse, hemidesmosome, integrin alpha1-beta1 complex, integrin alpha10-beta1 complex, integrin alpha11-beta1 complex, integrin alpha2-beta1 complex, integrin alpha3-beta1 complex, integrin alpha4-beta1 complex, integrin alpha5-beta1 complex, integrin alpha6-beta1 complex, integrin alpha7-beta1 complex, integrin alpha9-beta1 complex, integrin alphav-beta1 complex, integrin complex, intercalated disc, lamellipodium, melanosome, membrane, membrane raft, myelin sheath abaxonal region, neuromuscular junction, perinuclear region of cytoplasm, plasma membrane, postsynaptic membrane, receptor complex, recycling endosome, ruffle, ruffle membrane, sarcolemma, synapse, synaptic membrane
Pathways: Adaptive Immune System, Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Basigin interactions, Cell adhesion molecules - Mus musculus (mouse), Cell junction organization, Cell surface interactions at the vascular wall, Cell-Cell communication, Cell-extracellular matrix interactions, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Developmental Biology, Dilated cardiomyopathy - Mus musculus (mouse), ECM proteoglycans, ECM-receptor interaction - Mus musculus (mouse), Elastic fibre formation, Extracellular matrix organization, Fibronectin matrix formation, Focal adhesion - Mus musculus (mouse), G alpha (s) signalling events, GPCR downstream signalling, GPER1 signaling, Hemostasis, Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions, L1CAM interactions, Laminin interactions, Leishmaniasis - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Localization of the PINCH-ILK-PARVIN complex to focal adhesions, MET activates PTK2 signaling, MET interacts with TNS proteins, MET promotes cell motility, Molecules associated with elastic fibres, Nervous system development, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Platelet activation - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Response of endothelial cells to shear stress, Signal Transduction, Signal transduction by L1, Signaling by GPCR, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Small cell lung cancer - Mus musculus (mouse), Syndecan interactions, TGF-beta receptor signaling activates SMADs, Tight junction - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Yersinia infection - Mus musculus (mouse)
UniProt: P09055
Entrez ID: 16412
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ccdc86
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ccdc86 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ccdc86 (coiled-coil domain containing 86)
Type: protein-coding
Summary: Located in nucleus. Is expressed in urinary system. Orthologous to human CCDC86 (coiled-coil domain containing 86). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: chromosome segregation, mitotic nuclear division; CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9JJ89
Entrez ID: 108673
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Wdr27
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Wdr27 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Wdr27 (WD repeat domain 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C5V5
Entrez ID: 71682
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Myt1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Myt1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Myt1 (myelin transcription factor 1)
Type: protein-coding
Summary: This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: cell differentiation, diaphragm development, endocrine pancreas development, intracellular glucose homeostasis, negative regulation of gene expression, nervous system development, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of DNA-templated transcription, regulation of hormone metabolic process, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8CFC2
Entrez ID: 17932
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ppp4r2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ppp4r2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ppp4r2 (protein phosphatase 4, regulatory subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, hematopoietic progenitor cell differentiation, mRNA processing, regulation of double-strand break repair, regulation of double-strand break repair via homologous recombination; MF: protein binding, protein phosphatase regulator activity, protein-macromolecule adaptor activity; CC: centrosome, chromatin, cytoplasm, cytoskeleton, nucleoplasm, nucleus, protein phosphatase 4 complex
Pathways: DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends
UniProt: Q0VGB7
Entrez ID: 232314
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Vac14
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Vac14 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Vac14 (Vac14 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: phosphatidylinositol biosynthetic process, regulation of postsynaptic neurotransmitter receptor internalization, response to osmotic stress; MF: identical protein binding, kinase activator activity; CC: PAS complex, cytosol, endoplasmic reticulum, endosome, endosome membrane, membrane, presynaptic endosome, vacuolar membrane
Pathways: Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, Phospholipid metabolism, Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q80WQ2
Entrez ID: 234729
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nckap1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nckap1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nckap1 (NCK-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rac protein signal transduction, apical protein localization, basal protein localization, cell migration, cell migration involved in gastrulation, cell morphogenesis, cell projection assembly, cortical actin cytoskeleton organization, embryonic body morphogenesis, embryonic foregut morphogenesis, embryonic heart tube development, endoderm development, establishment or maintenance of actin cytoskeleton polarity, in utero embryonic development, lamellipodium assembly, mesodermal cell migration, neural tube closure, neuron projection morphogenesis, notochord development, notochord morphogenesis, paraxial mesoderm development, paraxial mesoderm morphogenesis, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of actin filament polymerization, positive regulation of lamellipodium assembly, protein stabilization, regulation of protein localization, somitogenesis, zygotic determination of anterior/posterior axis, embryo; MF: protein binding, small GTPase binding; CC: SCAR complex, cell projection, cytoplasm, filamentous actin, glutamatergic synapse, lamellipodium, lamellipodium membrane, membrane, plasma membrane, postsynapse, postsynaptic density, ruffle
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, VEGFA-VEGFR2 Pathway
UniProt: P28660
Entrez ID: 50884
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
BC005624
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of BC005624 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: BC005624 (cDNA sequence BC005624)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, chromosome segregation, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, regulation of homologous chromosome segregation; MF: RNA binding, U5 snRNA binding, molecular_function; CC: chromosome, chromosome, centromeric region, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q3TQI7
Entrez ID: 227707
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Brix1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Brix1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Brix1 (BRX1, biogenesis of ribosomes)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal large subunit assembly, ribosome biogenesis; MF: RNA binding, rRNA binding; CC: chromosome, nucleolus, nucleus
Pathways:
UniProt: Q9DCA5
Entrez ID: 67832
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Olig2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Olig2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Olig2 (oligodendrocyte transcription factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, central nervous system neuron differentiation, myelination, negative regulation of neuron differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, neuron differentiation, neuron fate commitment, oligodendrocyte cell fate specification, oligodendrocyte differentiation, positive regulation of oligodendrocyte differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, sensory organ development, spinal cord motor neuron differentiation, spinal cord oligodendrocyte cell differentiation, spinal cord oligodendrocyte cell fate specification, thalamus development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, HMG box domain binding, identical protein binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q9EQW6
Entrez ID: 50913
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Syt3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Syt3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Syt3 (synaptotagmin III)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, chemical synaptic transmission, exocytosis, positive regulation of dendrite extension, positive regulation of vesicle fusion, regulation of calcium ion-dependent exocytosis, regulation of postsynaptic membrane neurotransmitter receptor levels, response to calcium ion, vesicle-mediated transport; MF: SNARE binding, calcium ion sensor activity, calcium-dependent phospholipid binding, clathrin binding, identical protein binding, metal ion binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylserine binding, phospholipid binding, protein binding, protein heterodimerization activity, protein homodimerization activity, syntaxin binding; CC: cytoplasmic vesicle, endosome, exocytic vesicle, membrane, plasma membrane, postsynapse, synaptic membrane, transport vesicle membrane
Pathways:
UniProt: O35681
Entrez ID: 20981
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pdss1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pdss1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pdss1 (prenyl (solanesyl) diphosphate synthase, subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: isoprenoid biosynthetic process, lipid metabolic process, ubiquinone biosynthetic process; MF: all-trans-decaprenyl-diphosphate synthase activity, all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity, metal ion binding, prenyltransferase activity, protein binding, protein heterodimerization activity, transferase activity; CC: heterotetrameric polyprenyl diphosphate synthase complex, mitochondrion, polyprenyl diphosphate synthase complex, transferase complex, ubiquinone biosynthesis complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Terpenoid backbone biosynthesis - Mus musculus (mouse), Ubiquinol biosynthesis
UniProt: Q33DR2
Entrez ID: 56075
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Atp6v0b
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Atp6v0b in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Atp6v0b (ATPase, H+ transporting, lysosomal V0 subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport; MF: P-type proton-exporting transporter activity, proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: clathrin-coated vesicle membrane, cytoplasmic vesicle, endosome, membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, proton-transporting two-sector ATPase complex, proton-transporting domain, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Human papillomavirus infection - Mus musculus (mouse), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Phagosome - Mus musculus (mouse), ROS and RNS production in phagocytes, Rheumatoid arthritis - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Mus musculus (mouse), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Mus musculus (mouse)
UniProt: Q91V37
Entrez ID: 114143
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Coq5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Coq5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Coq5 (coenzyme Q5 methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, ubiquinone biosynthetic process; MF: 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity, methyltransferase activity, transferase activity; CC: extrinsic component of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, protein-containing complex, ubiquinone biosynthesis complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Ubiquinol biosynthesis, Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse)
UniProt: Q9CXI0
Entrez ID: 52064
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Supt6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Supt6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Supt6 (SPT6, histone chaperone and transcription elongation factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, blastocyst formation, mRNA processing, mRNA transport, nucleobase-containing compound metabolic process, nucleosome organization, positive regulation of transcription elongation by RNA polymerase II, regulation of isotype switching, regulation of muscle cell differentiation, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling; MF: DNA binding, histone binding, nucleic acid binding, nucleosome binding, protein binding; CC: nucleus, transcription elongation factor complex
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q62383
Entrez ID: 20926
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Uba5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Uba5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Uba5 (ubiquitin-like modifier activating enzyme 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: erythrocyte differentiation, megakaryocyte differentiation, neuromuscular process, protein K69-linked ufmylation, protein ufmylation, regulation of intracellular estrogen receptor signaling pathway, regulation of type II interferon production, response to endoplasmic reticulum stress, reticulophagy; MF: ATP binding, UFM1 activating enzyme activity, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, ubiquitin-like modifier activating enzyme activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q8VE47
Entrez ID: 66663
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Syvn1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Syvn1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Syvn1 (synovial apoptosis inhibitor 1, synoviolin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, immature B cell differentiation, in utero embryonic development, negative regulation of T-helper 1 type immune response, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein catabolic process, protein stabilization, protein ubiquitination, response to unfolded protein, retrograde protein transport, ER to cytosol, ubiquitin-dependent protein catabolic process; MF: ATPase binding, DNA-binding transcription factor binding, metal ion binding, protein binding, protein-folding chaperone binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-specific protease binding, unfolded protein binding, zinc ion binding; CC: Derlin-1 retrotranslocation complex, Hrd1p ubiquitin ligase ERAD-L complex, Hrd1p ubiquitin ligase complex, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane, nucleoplasm, smooth endoplasmic reticulum, ubiquitin ligase complex
Pathways: Hedgehog ligand biogenesis, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Signal Transduction, Signaling by Hedgehog, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9DBY1
Entrez ID: 74126
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Magoh
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Magoh in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Magoh (mago homolog, exon junction complex core component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, female gamete generation, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of alternative mRNA splicing, via spliceosome, regulation of mRNA processing, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation; CC: catalytic step 2 spliceosome, cytoplasm, cytosol, exon-exon junction complex, exon-exon junction subcomplex mago-y14, nuclear speck, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Mus musculus (mouse), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: P61327
Entrez ID: 17149
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Nars2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Nars2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Nars2 (asparaginyl-tRNA synthetase 2 (mitochondrial)(putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: asparaginyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, asparagine-tRNA ligase activity, ligase activity, nucleic acid binding, nucleotide binding; CC: cytosol, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8BGV0
Entrez ID: 244141
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl3
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl3 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl3 (mitochondrial ribosomal protein L3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q99N95
Entrez ID: 94062
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Usp36
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Usp36 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Usp36 (ubiquitin specific peptidase 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, negative regulation of macroautophagy, nucleolus organization, protein deubiquitination, protein stabilization, proteolysis, regulation of apoptotic process, regulation of protein stability, regulation of rRNA processing; MF: K48-linked deubiquitinase activity, RNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2B deubiquitinase activity, hydrolase activity, peptidase activity, transferase activity; CC: cytoplasm, cytosol, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: B1AQJ2
Entrez ID: 72344
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl15
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl15 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl15 (mitochondrial ribosomal protein L15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, mitochondrial translation, mitochondrion organization, translation; MF: structural constituent of ribosome; CC: large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CPR5
Entrez ID: 27395
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Btaf1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Btaf1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Btaf1 (B-TFIID TATA-box binding protein associated factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, DNA binding, TBP-class protein binding, helicase activity, hydrolase activity, nucleotide binding, transcription coregulator activity; CC: nucleoplasm, nucleus
Pathways:
UniProt: E9QAE3
Entrez ID: 107182
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gpr160
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gpr160 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gpr160 (G protein-coupled receptor 160)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in trigeminal ganglion. Orthologous to human GPR160 (G protein-coupled receptor 160). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; CC: membrane, plasma membrane, receptor complex
Pathways:
UniProt: Q3U3F9
Entrez ID: 71862
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrpl54
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrpl54 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrpl54 (mitochondrial ribosomal protein L54)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including brain; brown fat; early conceptus; gonad; and skeleton. Orthologous to human MRPL54 (mitochondrial ribosomal protein L54). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CPW3
Entrez ID: 66047
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ei24
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ei24 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ei24 (etoposide induced 2.4 mRNA)
Type: protein-coding
Summary: Predicted to enable importin-alpha family protein binding activity. Acts upstream of or within several processes, including cellular response to UV-C; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of protein import into nucleus. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human EI24 (EI24 autophagy associated transmembrane protein). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, autophagy, cellular response to UV-C, intrinsic apoptotic signaling pathway in response to DNA damage, macroautophagy, negative regulation of cell growth, negative regulation of protein import into nucleus, neuromuscular process controlling balance, positive regulation of intrinsic apoptotic signaling pathway, response to xenobiotic stimulus; MF: importin-alpha family protein binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear membrane, nucleus
Pathways: p53 signaling pathway - Mus musculus (mouse)
UniProt: Q61070
Entrez ID: 13663
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Chmp6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Chmp6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Chmp6 (charged multivesicular body protein 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of mitotic spindle assembly, regulation of protein catabolic process, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: protein-containing complex binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, endomembrane system, endosome, endosome membrane, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, midbody, multivesicular body, multivesicular body membrane, nuclear pore, plasma membrane
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport
UniProt: P0C0A3
Entrez ID: 208092
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ppp1r10
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ppp1r10 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ppp1r10 (protein phosphatase 1, regulatory subunit 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, negative regulation of cardiac muscle cell apoptotic process, negative regulation of mitotic DNA damage checkpoint, negative regulation of transcription elongation by RNA polymerase II, positive regulation of telomere maintenance, positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled, positive regulation of transcription elongation by RNA polymerase II, protein stabilization, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: DNA binding, RNA binding, enzyme-substrate adaptor activity, metal ion binding, protein binding, protein phosphatase 1 binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, zinc ion binding; CC: PTW/PP1 phosphatase complex, chromatin, chromosome, chromosome, telomeric region, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q80W00
Entrez ID: 52040
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Fdxr
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Fdxr in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Fdxr (ferredoxin reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol metabolic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, ubiquinone biosynthetic process; MF: ferredoxin-NADP+ reductase activity, oxidoreductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Biological oxidations, Cytochrome P450 - arranged by substrate type, Electron transport from NADPH to Ferredoxin, Endogenous sterols, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Mitochondrial iron-sulfur cluster biogenesis, Phase I - Functionalization of compounds, Pregnenolone biosynthesis
UniProt: Q61578
Entrez ID: 14149
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Lin54
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Lin54 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Lin54 (lin-54 DREAM MuvB core complex component)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome organization, regulation of DNA-templated transcription; MF: DNA binding, metal ion binding, minor groove of adenine-thymine-rich DNA binding, transcription regulatory region nucleic acid binding; CC: RNA polymerase II transcription repressor complex, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cellular senescence - Mus musculus (mouse), G0 and Early G1, Mitotic G1 phase and G1/S transition
UniProt: Q571G4
Entrez ID: 231506
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Trmt6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Trmt6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Trmt6 (tRNA methyltransferase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA processing, tRNA methylation, tRNA processing; CC: nucleus, tRNA (m1A) methyltransferase complex
Pathways:
UniProt: Q8CE96
Entrez ID: 66926
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gm13057
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gm13057 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gm13057 (predicted gene 13057)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation; MF: molecular_function, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cellular_component
Pathways:
UniProt:
Entrez ID: 100040861
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Itga6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Itga6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Itga6 (integrin alpha 6)
Type: protein-coding
Summary: This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 4 to bind laminin and to form the main component of hemidesmosomes, which mediate attachment of epithelia to basement membranes. In mouse, deficiency of this gene is associated with absence of hemidesmosomes, severe skin blistering, and early post-natal death. In humans mutations of this gene are associated with epidermolysis bullosa. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013].
Gene Ontology: BP: brown fat cell differentiation, cell adhesion, cell adhesion mediated by integrin, cell-cell adhesion, cell-matrix adhesion, cell-substrate adhesion, filopodium assembly, integrin-mediated signaling pathway, leukocyte migration, lymphoid lineage cell migration, nail development, negative regulation of extrinsic apoptotic signaling pathway, odontogenesis of dentin-containing tooth, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of cell-cell adhesion, positive regulation of cell-substrate adhesion, positive regulation of neuron projection development, positive regulation of transcription by RNA polymerase II, skin morphogenesis; MF: insulin-like growth factor I binding, integrin binding, laminin binding, metal ion binding, neuregulin binding, protein binding, protein-containing complex binding, signaling receptor activity; CC: adherens junction, basal part of cell, basal plasma membrane, basement membrane, basolateral plasma membrane, cell surface, external side of plasma membrane, filopodium, hemidesmosome, integrin alpha6-beta1 complex, integrin alpha6-beta4 complex, integrin complex, membrane, plasma membrane
Pathways: Arrhythmogenic right ventricular cardiomyopathy - Mus musculus (mouse), Basigin interactions, Cell adhesion molecules - Mus musculus (mouse), Cell junction organization, Cell surface interactions at the vascular wall, Cell-Cell communication, Dilated cardiomyopathy - Mus musculus (mouse), ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Focal adhesion - Mus musculus (mouse), Hematopoietic cell lineage - Mus musculus (mouse), Hemostasis, Human papillomavirus infection - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Integrin cell surface interactions, Laminin interactions, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Syndecan interactions, Toxoplasmosis - Mus musculus (mouse), Type I hemidesmosome assembly
UniProt: Q61739
Entrez ID: 16403
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cdk7
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cdk7 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cdk7 (cyclin dependent kinase 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II promoter clearance, RNA polymerase II transcription initiation surveillance, cell division, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription pausing by RNA polymerase II; MF: ATP binding, ATP-dependent activity, acting on DNA, RNA polymerase II CTD heptapeptide repeat S5 kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: CAK-ERCC2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, fibrillar center, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, transcription factor TFIIH core complex, transcription factor TFIIH holo complex, transcription factor TFIIK complex
Pathways: Basal transcription factors - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Repair, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, G1 Phase, G1/S Transition, G2/M Transition, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, RUNX1 regulates transcription of genes involved in differentiation of HSCs, S Phase, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, mRNA Capping
UniProt: Q03147
Entrez ID: 12572
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ints6
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ints6 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ints6 (integrator complex subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, protein localization to chromatin, snRNA 3'-end processing, snRNA processing, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: protein-macromolecule adaptor activity; CC: INTAC complex, actin cytoskeleton, chromatin, chromosome, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q6PCM2
Entrez ID: 18130
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Slc29a4
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Slc29a4 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Slc29a4 (solute carrier family 29 (nucleoside transporters), member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adenosine transport, cellular detoxification, dopamine transport, dopamine uptake, epinephrine transport, epinephrine uptake, export across plasma membrane, histamine transport, histamine uptake, monoamine transport, monoatomic cation transmembrane transport, neurotransmitter transport, norepinephrine transport, norepinephrine uptake, nucleoside transmembrane transport, organic acid transmembrane transport, organic cation transport, serotonin transport, serotonin uptake, xenobiotic transport; MF: efflux transmembrane transporter activity, monoamine transmembrane transporter activity, monoatomic cation transmembrane transporter activity, neurotransmitter transmembrane transporter activity, nucleoside transmembrane transporter activity, organic acid transmembrane transporter activity, organic cation transmembrane transporter activity, toxin transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane, presynapse
Pathways: SLC-mediated transmembrane transport, Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q8R139
Entrez ID: 243328
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Cox15
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Cox15 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Cox15 (cytochrome c oxidase assembly protein 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytochrome complex assembly, heme A biosynthetic process, heme biosynthetic process; MF: heme A synthase activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor, oxidoreductase activity, acting on the CH-CH group of donors; CC: cytochrome complex, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Heme biosynthesis, Metabolism, Metabolism of porphyrins, Oxidative phosphorylation - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: Q8BJ03
Entrez ID: 226139
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Polr3c
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Polr3c in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Polr3c (polymerase (RNA) III (DNA directed) polypeptide C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production; MF: DNA binding, nucleotidyltransferase activity, single-stranded DNA binding, transferase activity; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway - Mus musculus (mouse), Gene expression (Transcription), RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase - Mus musculus (mouse)
UniProt: Q9D483
Entrez ID: 74414
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rtcb
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rtcb in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rtcb (RNA 2',3'-cyclic phosphate and 5'-OH ligase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, in utero embryonic development, placenta development, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: GTP binding, RNA ligase (GTP) activity, ligase activity, ligase activity, forming phosphoric ester bonds, metal ion binding, nucleotide binding, vinculin binding; CC: cytoplasm, cytosol, endoplasmic reticulum membrane, nuclear envelope, nucleoplasm, nucleus, tRNA-splicing ligase complex
Pathways:
UniProt: Q99LF4
Entrez ID: 28088
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Rexo2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Rexo2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Rexo2 (RNA exonuclease 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA metabolic process, mitochondrial RNA surveillance, nucleobase-containing compound metabolic process; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, 3'-5'-RNA exonuclease activity, exonuclease activity, hydrolase activity, magnesium ion binding, metal ion binding, nuclease activity, nucleic acid binding; CC: cytoplasm, focal adhesion, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion, nucleolus, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: Q9D8S4
Entrez ID: 104444
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Ddx10
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Ddx10 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Ddx10 (DEAD box helicase 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anterior head development, rRNA processing; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: cytoplasm, nucleolus, nucleus
Pathways:
UniProt: Q80Y44
Entrez ID: 77591
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Wars2
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Wars2 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Wars2 (tryptophanyl tRNA synthetase 2 (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial tryptophanyl-tRNA aminoacylation, positive regulation of angiogenesis, tRNA aminoacylation for protein translation, translation, tryptophanyl-tRNA aminoacylation, vasculogenesis; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, tryptophan-tRNA ligase activity; CC: mitochondrial matrix, mitochondrion, nucleoplasm, plasma membrane
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q9CYK1
Entrez ID: 70560
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mvk
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mvk in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mvk (mevalonate kinase)
Type: protein-coding
Summary: This gene encodes mevalonate kinase, a key enzyme involved in the biosynthesis of cholesterol and non-sterol isoprenes. The complete lack of encoded protein is lethal to mouse embryos. Mice lacking one allele of this gene exhibit increased levels of mevalonate in spleen, heart and kidney, as well as increased levels of serum immunoglobulins A and D. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, isopentenyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid metabolic process, negative regulation of inflammatory response, negative regulation of translation, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: ATP binding, identical protein binding, kinase activity, mRNA binding, magnesium ion binding, metal ion binding, mevalonate kinase activity, nucleotide binding, sequence-specific mRNA binding, transferase activity; CC: cytoplasm, cytosol, peroxisome
Pathways: Cholesterol biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroids, Peroxisome - Mus musculus (mouse), Terpenoid backbone biosynthesis - Mus musculus (mouse), mevalonate pathway I, superpathway of cholesterol biosynthesis
UniProt: Q9R008
Entrez ID: 17855
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Pga5
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Pga5 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Pga5 (pepsinogen 5, group I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: aspartic-type endopeptidase activity, hydrolase activity, peptidase activity; CC: cellular_component, extracellular region
Pathways: Protein digestion and absorption - Mus musculus (mouse)
UniProt: Q9D106
Entrez ID: 58803
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Clp1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Clp1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Clp1 (CLP1, cleavage and polyadenylation factor I subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RISC complex assembly, RNA processing, cerebellar cortex development, global gene silencing by mRNA cleavage, mRNA 3'-end processing, mRNA processing, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: ATP binding, ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity, ATP-dependent polynucleotide 5'-hydroxyl-kinase activity, ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity, kinase activity, nucleotide binding, polynucleotide 5'-hydroxyl-kinase activity, transferase activity; CC: cytosol, mRNA cleavage factor complex, nucleoplasm, nucleus, tRNA-intron endonuclease complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q99LI9
Entrez ID: 98985
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Adamdec1
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Adamdec1 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Adamdec1 (ADAM-like, decysin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, extracellular matrix organization, inflammatory response, proteolysis, tissue remodeling, wound healing; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: cellular_component, extracellular region
Pathways:
UniProt: Q9R0X2
Entrez ID: 58860
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Gm10408
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Gm10408 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Gm10408 (predicted gene 10408)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: K7N693
Entrez ID: 100041840
|
SCREEN_18_HITS_ONLY_FOR_INVERSE.tsv
|
mouse
|
knockout
|
Mrps17
|
NG2-3112 mouse glioblastoma cells
|
decreased sensitivity to gliocidin and subsequently glioblastoma cell survival
| 1
|
difficult
|
Does knockout of Mrps17 in NG2-3112 mouse glioblastoma cells causally result in decreased sensitivity to gliocidin and subsequently glioblastoma cell survival?
|
Gene: Mrps17 (mitochondrial ribosomal protein S17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CQE3
Entrez ID: 66258
|
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