screen_file string | organism string | perturbation string | gene string | cell string | phenotype string | hit int64 | benchmark_type string | prompt string | gene_context string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Uqcrc1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Uqcrc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Uqcrc1 (ubiquinol-cytochrome c reductase core protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, mitochondrial respiratory chain complex III assembly, response to activity, re... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Mrpl39 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Mrpl39 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Mrpl39 (mitochondrial ribosomal protein L39)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, mitochondrion organization, translation; MF: nucleotide binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondri... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Manf | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Manf in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Manf (mesencephalic astrocyte-derived neurotrophic factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATF6-mediated unfolded protein response, regulation of response to endoplasmic reticulum stress, response to unfolded protein, vasoconstriction of artery invol... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Map3k15 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Map3k15 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Map3k15 (mitogen-activated protein kinase kinase kinase 15)
Type: protein-coding
Summary: Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in JNK cascade and p38MAPK cascade. Is expressed in pancreas. Orthologous to human MAP3K15 (mitogen-activated protein kinase kin... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gfm2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Gfm2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gfm2 (G elongation factor, mitochondrial 2)
Type: protein-coding
Summary: Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Located in mitochondrion. Is expressed in brain; dorsal root ganglion; liver lobe; spinal cord; and thymus ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gtf2f1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Gtf2f1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gtf2f1 (general transcription factor IIF, polypeptide 1)
Type: protein-coding
Summary: Predicted to enable several functions, including RNA polymerase II general transcription initiation factor activity; TFIIF-class transcription factor complex binding activity; and promoter-specific chromatin bin... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Zfp628 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Zfp628 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Zfp628 (zinc finger protein 628)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: developmental process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatoge... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Psmd4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Psmd4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Psmd4 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular adaptor activity, polyubiquitin modification-dependent protein binding; CC: cytosol, nucleoplasm, nucleus, proteas... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Pigk | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Pigk in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Pigk (phosphatidylinositol glycan anchor biosynthesis, class K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, GPI anchored protein biosynthesis, attachment of GPI anchor to protein, proteolysis; MF: GPI-anchor transamidase activity... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rmnd5a | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Rmnd5a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rmnd5a (required for meiotic nuclear division 5 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein l... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Smad4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Smad4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Smad4 (SMAD family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, DNA-templated transcription, ERK1 and ERK2 cascade, SMAD protein signal transduction, activin receptor signaling pathway, adrenal gland development, anatomical struct... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cap2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Cap2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cap2 (cyclase associated actin cytoskeleton regulatory protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, cAMP-mediated signaling, cell morphogenesis, cytoskeleton organization, presynaptic actin ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Wbp4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Wbp4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Wbp4 (WW domain binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, metal ion binding, nucleic acid binding, proline-rich region bindin... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Huwe1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Huwe1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Huwe1 (HECT, UBA and WWE domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, Golgi organization, base-excision repair, canonical NF-kappaB signal transduction, cell differentiation, chromatin remodeling, circadian re... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Smg7 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Smg7 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Smg7 (SMG7 nonsense mediated mRNA decay factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; MF: protein phosphatase 2A binding, telomerase RNA binding, telomeric DNA binding; CC: cytoplasm, cyt... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Aadac | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Aadac in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Aadac (arylacetamide deacetylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, positive regulation of triglyceride catabolic process; MF: carboxylic ester hydrolase activity, catalytic activity, deacetylase activity, hydrolase activity, l... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Zbtb11 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Zbtb11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Zbtb11 (zinc finger and BTB domain containing 11)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DN... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ttc39d | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Ttc39d in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ttc39d (tetratricopeptide repeat domain 39D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, negative regulation of cholesterol storage, regulation of cholesterol efflux, regulation of cholesterol metabolic process
Pathways:
... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Birc6 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Birc6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Birc6 (baculoviral IAP repeat-containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cell division, labyrinthine layer development, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, plac... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Trappc4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Trappc4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Trappc4 (trafficking protein particle complex 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, autophagy, dendrite development, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated t... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ogt | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Ogt in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ogt (O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, apoptotic process, cellular response to glucose stimulus, cellular respons... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gigyf2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Gigyf2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gigyf2 (GRB10 interacting GYF protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, feeding behavior, homeostasis of number of cells within a tissue, insulin-like growth factor receptor signaling pathway, mRNA destabilization, mitotic... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rrm2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Rrm2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rrm2 (ribonucleotide reductase M2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2'-deoxyribonucleotide biosynthetic process, blastocyst development, deoxyribonucleotide biosynthetic process, deoxyribonucleotide metabolic process, positive regulation of G1/S trans... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Lztr1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Lztr1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Lztr1 (leucine-zipper-like transcriptional regulator, 1)
Type: protein-coding
Summary: This gene encodes a member of the BR-C, ttk and bab-kelch superfamily that, in humans, localizes to the Golgi network and is associated with the ras / mitogen-activated protein kinase pathway. Loss-of-function m... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Zfp937 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Zfp937 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Zfp937 (zinc finger protein 937)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Hira | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Hira in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Hira (histone cell cycle regulator)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and histone binding activity. Predicted to contribute to nucleosome binding activity. Acts upstream of or within gastrulation; muscle c... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ccnf | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Ccnf in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ccnf (cyclin F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cell division, negative regulation of centrosome duplication, placenta development, protei... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Meaf6 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Meaf6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Meaf6 (MYST/Esa1-associated factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, re... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Pold1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Pold1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Pold1 (polymerase (DNA directed), delta 1, catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-template... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gps2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Gps2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gps2 (G protein pathway suppressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, negative regulation of B cell receptor signaling pathway, negative regulation of JNK cascade, negative regulation of fat cell differentiation, negative regu... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Zc3h7b | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Zc3h7b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Zc3h7b (zinc finger CCCH type containing 7B)
Type: protein-coding
Summary: Predicted to enable miRNA binding activity. Predicted to be involved in miRNA processing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Orthologous to human ZC3H7... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Snip1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Snip1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Snip1 (Smad nuclear interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, miRNA processing, negative regulation of canonical NF-kappaB signal transduction, positive regulation of transcr... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Nfib | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Nfib in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Nfib (nuclear factor I/B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, anterior commissure morphogenesis, brain development, cell differentiation involved in salivary gland development, cell proliferation in forebrain, chondrocyte differentiation... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Usp19 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Usp19 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Usp19 (ubiquitin specific peptidase 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, negative regulation of proteasomal protein catabolic process, negative regulation of skeletal muscle tissue development, positive regulation of cell cycle process, ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gbp10 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Gbp10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gbp10 (guanylate-binding protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipopolysaccharide, cellular response to type II interferon, defense response to Gram-positive bacterium, defense response to protozoan, immune system process, ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ube2a | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Ube2a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ube2a (ubiquitin-conjugating enzyme E2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, G2/M transition of mitotic cell cycle, blastocyst hatching, chromatin remodeling, in utero embryonic development, maternal process involved in f... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Lsm1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Lsm1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Lsm1 (LSM1 homolog, mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, deadenylation-dependent decapping of nuclear-transcribed mRNA, histone mRNA catabolic process, mRNA processing, negative regulation of neuron differentiati... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Lpgat1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Lpgat1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Lpgat1 (lysophosphatidylglycerol acyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, phosphatidylethanolamine acyl-chain remodeling, phosphatidylinositol acyl-chain remodeling, phospholipid biosynthetic process, positive regul... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cbl | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Cbl in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cbl (Casitas B-lineage lymphoma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, bone resorption, cell surface receptor signaling pathway, cellular response to hypoxia, cellular response to nerve growth factor stimulus, cellular response to plat... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cwc27 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Cwc27 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cwc27 (CWC27 spliceosome-associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein folding; CC: U2-type precatalytic spliceosome, catalytic step 2 spliceosome, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-C... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rnf40 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Rnf40 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rnf40 (ring finger protein 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of proteasomal protein catabolic process, positive regulation of protein polyubiquitination, positive regulation of transcription by RNA polyme... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Mitd1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Mitd1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Mitd1 (MIT, microtubule interacting and transport, domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, midbody abscission, mitotic cytokinesis; MF: identical protein binding, phosphatidylinositol binding, protein domain specific bindi... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Mier3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Mier3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Mier3 (MIER family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: histone deacetylase binding, transcription corepressor activity; CC: nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q3UHF3
Entrez ID: 218613 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Zfx | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Zfx in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Zfx (zinc finger protein X-linked)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin insulator sequence binding activity. Acts ups... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Chek1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Chek1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Chek1 (checkpoint kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, G2/M transition of mitotic cell cycle, apoptotic process, apoptotic process involved in development, cellular response to me... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Otud5 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Otud5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Otud5 (OTU domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation, T-helper 17 cell lineage commitment, cell differentiation, negative regulation of canonical Wnt signaling pathway, negative regulation of... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Kpna2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Kpna2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Kpna2 (karyopherin subunit alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, entry of viral genome into host nucleus through nuclear pore complex via importin, non-canonical NF-kappaB signal transduction, positive regu... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ranbp9 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Ranbp9 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ranbp9 (RAN binding protein 9)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in cytoskeleton organization and negative regulation of ERK1 and ERK2 cascade. Located in cytoplasm. Is expressed in cerebral cortex intermediate zone; cerebral ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Hdac8 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Hdac8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Hdac8 (histone deacetylase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to forskolin, cellular response to trichostatin A, chromatin organization, heterochromatin formation, mitotic sister chromatid cohesion, negative regulation of gene expre... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Brap | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Brap in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Brap (BRCA1 associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, Ras protein signal transduction, negative regulation of signal transduction, protein ubiquitination; MF: identical protein binding, metal ion binding, nuclear localization ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Tfpt | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Tfpt in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Tfpt (TCF3 (E2A) fusion partner)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, apoptotic process, apoptotic signaling pathway, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-t... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Nosip | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Nosip in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Nosip (nitric oxide synthase interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination, regulation of nitric oxide biosynthetic process; MF: molecular sequestering activity, transferase activity, ubiquitin protein ligase activity; C... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ubr5 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Ubr5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ubr5 (ubiquitin protein ligase E3 component n-recognin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, cytoplasm protein quality control, cytoplasm protein quality control by the ubiquiti... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cadm1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Cadm1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cadm1 (cell adhesion molecule 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, bone development, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, cell differentiation, cell recognition, detection... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Maea | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Maea in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Maea (macrophage erythroblast attacher)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell division, cytoskeleton organization, enucleate erythrocyte development, erythrocyte development, erythrocyte maturation, negative regulation of myeloid cell a... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Kpnb1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Kpnb1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Kpnb1 (karyopherin subunit beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, RNA import into nucleus, astral microtubule organization, establishment of mitotic spindle localization, intracellular protein transport, mito... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Nprl2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Nprl2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Nprl2 (NPR2 like, GATOR1 complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid starvation, cellular response to methionine, cellular response to nutrient levels, cytoplasmic translation, negative regulation... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ezh2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Ezh2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: Enables several functions, including DNA binding activity; RNA binding activity; and transcription corepressor activity. Involved in B cell differentiation; facultative heterochromatin formation; and reg... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Zfp36l2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Zfp36l2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Zfp36l2 (zinc finger protein 36, C3H type-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, ERK1 and ERK2 cascade, MAPK cascade, T cell differentiation in thymus, cellular response to epidermal growth factor stimulus, cell... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rest | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Rest in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rest (RE1-silencing transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: auditory receptor cell stereocilium organization, cardiac muscle cell myoblast differentiation, cellular response to electrical stimulus, cellular response to glucocorticoid st... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Lig1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Lig1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Lig1 (ligase I, DNA, ATP-dependent)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA recombination, DNA repair, DNA replication, Okazaki fragment processing involved in mitotic DNA replication, base-excision repair, ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Sf3b5 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Sf3b5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Sf3b5 (splicing factor 3b, subunit 5)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and splicing factor binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U12-type spliceosomal compl... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rnf146 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Rnf146 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rnf146 (ring finger protein 146)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, cellular response to hydrogen peroxide, negative regulation of cellular response to oxidative stress, positive regulation of canonical Wnt signaling pathway, prot... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cyp51 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Cyp51 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cyp51 (cytochrome P450, family 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via 24,25-dihydrolanosterol, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Tsc2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Tsc2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Tsc2 (TSC complex subunit 2)
Type: protein-coding
Summary: Enables 14-3-3 protein binding activity and GTPase activator activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several process... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Vcpip1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Vcpip1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Vcpip1 (valosin containing protein (p97)/p47 complex interacting protein 1)
Type: protein-coding
Summary: This gene encodes a deubiquitinating enzyme that interacts with valosin containing protein p97 and plays a role in the assembly of Golgi apparatus during mitosis. [provided by RefSeq, Dec 2014... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Abcc1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Abcc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Abcc1 (ATP-binding cassette, sub-family C member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ube2h | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Ube2h in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ube2h (ubiquitin-conjugating enzyme E2H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein polyubiquitination, protein ubiq... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gid8 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Gid8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gid8 (GID complex subunit 8)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; and proteasome-mediated ubiquitin-dependent protein catabo... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Nprl3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Nprl3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Nprl3 (nitrogen permease regulator-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta morphogenesis, cardiac muscle tissue development, cellular response to amino acid starvation, negative regulation of TOR signaling, negative regulation of TORC1 signalin... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Upf1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Upf1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Upf1 (UPF1 RNA helicase and ATPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, DNA repair, DNA replication, cell cycle phase transition, cellular response to interleukin-1, cellular response to lipopolysaccharide, histone m... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Usp18 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Usp18 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Usp18 (ubiquitin specific peptidase 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, negative regulation of type I interferon-mediated signaling pathway, protein deubiquitination, proteolysis, regulation of inflammatory response,... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Morf4l1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Morf4l1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Morf4l1 (mortality factor 4 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell population proliferation, chromatin organization, chromatin remodeling, double-strand break repair via homologous recombinati... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Trip12 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Trip12 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Trip12 (thyroid hormone receptor interactor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, heterochromatin boundary formation, proteasome-mediated ubiquitin-dependent protein catabolic ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Upf2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Upf2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Upf2 (UPF2 regulator of nonsense transcripts homolog (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ regeneration, liver development, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, response to unfolded protein; MF: RNA bin... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Sumo2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Sumo2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Sumo2 (small ubiquitin-like modifier 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, protein sumoylation; MF: SUMO transfe... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Wdr26 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Wdr26 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Wdr26 (WD repeat domain 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: GID complex, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cdyl | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Cdyl in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cdyl (chromodomain protein, Y chromosome-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of peptidyl-lysine crotonylation, random inactivation of X chromosome, sperma... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Spop | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Spop in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Spop (speckle-type BTB/POZ protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose homeostasis, negative regulation of transcription by RNA polymerase II, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, pos... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Sox6 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Sox6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Sox6 (SRY (sex determining region Y)-box 6)
Type: protein-coding
Summary: This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alterna... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Nt5c3b | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 1 | difficult | Does knockout of Nt5c3b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Nt5c3b (5'-nucleotidase, cytosolic IIIB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 5'-nucleotidase activity, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding; CC: cytoplasm
Pathways: Deadenylation-dependent mRNA decay, ... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Stk11 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Stk11 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Stk11 (serine/threonine kinase 11)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. ... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | H2-K1 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of H2-K1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: H2-K1 (histocompatibility 2, K1, K region)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation, antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent, antigen processing and pr... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Keap1 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Keap1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Keap1 (kelch-like ECH-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to carbohydrate stimulus, cellular response to interleukin-4, cellular response to oxidative stress, in utero embryonic development, negative regulation of ... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Pcna | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Pcna in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Pcna (proliferating cell nuclear antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, base-excision repair, gap-filling, cellular response to UV, cellular response to hydrogen peroxide, cellular response to xenob... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Top1 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Top1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Top1 (topoisomerase (DNA) I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA topological change, animal organ regeneration, cellular response to luteinizing hormone stimulus, chromatin remodeling, chromosome segregation, circadian regulation of ... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Setdb1 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Setdb1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Setdb1 (SET domain, bifurcated 1)
Type: protein-coding
Summary: Enables DNA binding activity; histone H3K9 methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation-dependent constitutive heterochromatin formation; negative regulation of single stran... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Map3k1 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Map3k1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Map3k1 (mitogen-activated protein kinase kinase kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, MAPK cascade, apoptotic mitochondrial changes, camera-type eye development, cell surface receptor signaling pathway, epithelial cell morphogenesis,... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Egfr | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Egfr in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Egfr (epidermal growth factor receptor)
Type: protein-coding
Summary: Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in ERBB2-EGFR signaling pathway; cellular response to amino acid stimulus; and positive regulation of fibroblast proliferat... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Tsc2 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Tsc2 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Tsc2 (TSC complex subunit 2)
Type: protein-coding
Summary: Enables 14-3-3 protein binding activity and GTPase activator activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several process... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Setd2 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Setd2 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Setd2 (SET domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, angiogenesis, autophagosome assembly, cell differentiation, cell migration involved in vasculogenesis, chromatin organization, coronary vasculature morph... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Tap1 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Tap1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Tap1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP))
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Casp8 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Casp8 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Casp8 (caspase 8)
Type: protein-coding
Summary: This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis f... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Rps6 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Rps6 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Rps6 (ribosomal protein S6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, T cell differentiation in thymus, T cell proliferation involved in immune response, TOR signaling, activation-induced cell death of T cells, cellular r... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Men1 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Men1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Men1 (multiple endocrine neoplasia 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, MAPK cascade, T-helper 2 cell differentiation, chromatin organization, chromatin remodeling, embryonic skeletal system morphogenesis, hemopoiesis, leukocyte ho... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Cd47 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Cd47 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Cd47 (CD47 antigen (Rh-related antigen, integrin-associated signal transducer))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP export, angiogenesis, apoptotic process, cell adhesion, cell migration, cell-cell adhesion, cellular response to interleukin-1, cellul... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Asxl1 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Asxl1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Asxl1 (ASXL transcriptional regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, bone development, bone marrow development, cell morphogenesis, chromatin organization, heart morphogenesis, hematopoietic or lymphoid organ developme... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Sufu | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Sufu in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Sufu (SUFU negative regulator of hedgehog signaling)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, coronary vasculature development, determination of left/right symmetry, dorsal/ventral neural tube patterning, heart looping, maintenance of prote... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | B2m | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of B2m in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: B2m (beta-2 microglobulin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation in thymus, amyloid fibril formation, antibacterial humoral response, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processi... |
SCREEN_17_HITS_ONLY.tsv | mouse | knockout | Stat1 | 3LL Lewis lung carcinoma cells | increased resistance to PD1 blockade and lung carcinoma cell survival | 1 | difficult | Does knockout of Stat1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival? | Gene: Stat1 (signal transducer and activator of transcription 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, blood circulation, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor sign... |
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