screen_file
string | organism
string | perturbation
string | gene
string | cell
string | phenotype
string | hit
int64 | benchmark_type
string | prompt
string | gene_context
string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Uqcrc1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Uqcrc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Uqcrc1 (ubiquinol-cytochrome c reductase core protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, mitochondrial respiratory chain complex III assembly, response to activity, response to alkaloid; MF: metal ion binding, protein binding, protein-containing complex binding, ubiquitin protein ligase binding; CC: membrane, mitochondrial inner membrane, mitochondrion, myelin sheath, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex III assembly, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CZ13
Entrez ID: 22273
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl39
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl39 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl39 (mitochondrial ribosomal protein L39)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, mitochondrion organization, translation; MF: nucleotide binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9JKF7
Entrez ID: 27393
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Manf
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Manf in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Manf (mesencephalic astrocyte-derived neurotrophic factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATF6-mediated unfolded protein response, regulation of response to endoplasmic reticulum stress, response to unfolded protein, vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure; MF: growth factor activity, lipid binding, sulfatide binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen, extracellular region, extracellular space, perinuclear region of cytoplasm, sarcoplasmic reticulum, sarcoplasmic reticulum lumen
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q9CXI5
Entrez ID: 74840
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Map3k15
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Map3k15 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Map3k15 (mitogen-activated protein kinase kinase kinase 15)
Type: protein-coding
Summary: Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in JNK cascade and p38MAPK cascade. Is expressed in pancreas. Orthologous to human MAP3K15 (mitogen-activated protein kinase kinase kinase 15). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: JNK cascade, MAPK cascade, p38MAPK cascade; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: A2AQW0
Entrez ID: 270672
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gfm2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gfm2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gfm2 (G elongation factor, mitochondrial 2)
Type: protein-coding
Summary: Predicted to enable GTPase activity. Predicted to be involved in mitochondrial translation and ribosome disassembly. Located in mitochondrion. Is expressed in brain; dorsal root ganglion; liver lobe; spinal cord; and thymus primordium. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 39. Orthologous to human GFM2 (GTP dependent ribosome recycling factor mitochondrial 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, ribosome disassembly, translation; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: mitochondrial matrix, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial translation, Mitochondrial translation termination, Translation
UniProt: Q8R2Q4
Entrez ID: 320806
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gtf2f1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gtf2f1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gtf2f1 (general transcription factor IIF, polypeptide 1)
Type: protein-coding
Summary: Predicted to enable several functions, including RNA polymerase II general transcription initiation factor activity; TFIIF-class transcription factor complex binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cell junction and nucleoplasm. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIF complex. Is expressed in genitourinary system. Orthologous to human GTF2F1 (general transcription factor IIF subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of protein binding, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, response to virus, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, TFIIF-class transcription factor complex binding, phosphatase activator activity, promoter-specific chromatin binding, protein binding, protein domain specific binding, protein phosphatase binding; CC: cell junction, nucleoplasm, nucleus, protein-containing complex, transcription factor TFIID complex, transcription factor TFIIF complex
Pathways: Basal transcription factors - Mus musculus (mouse), ESR-mediated signaling, Estrogen-dependent gene expression, FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q3THK3
Entrez ID: 98053
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zfp628
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Zfp628 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zfp628 (zinc finger protein 628)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: developmental process, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8CJ78
Entrez ID: 232816
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Psmd4
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Psmd4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Psmd4 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding, molecular adaptor activity, polyubiquitin modification-dependent protein binding; CC: cytosol, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism of proteins, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Prion disease - Mus musculus (mouse), Proteasome - Mus musculus (mouse), Proteasome assembly, Spinocerebellar ataxia - Mus musculus (mouse), Targeted protein degradation
UniProt: O35226
Entrez ID: 19185
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pigk
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Pigk in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pigk (phosphatidylinositol glycan anchor biosynthesis, class K)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, GPI anchored protein biosynthesis, attachment of GPI anchor to protein, proteolysis; MF: GPI-anchor transamidase activity, metal ion binding, peptidase activity, transferase activity; CC: GPI-anchor transamidase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Attachment of GPI anchor to uPAR, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9CXY9
Entrez ID: 329777
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rmnd5a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Rmnd5a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rmnd5a (required for meiotic nuclear division 5 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: GID complex, cytoplasm, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q80YQ8
Entrez ID: 68477
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Smad4
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Smad4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Smad4 (SMAD family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: BMP signaling pathway, DNA-templated transcription, ERK1 and ERK2 cascade, SMAD protein signal transduction, activin receptor signaling pathway, adrenal gland development, anatomical structure morphogenesis, anterior/posterior pattern specification, atrioventricular canal development, atrioventricular valve formation, axon guidance, brainstem development, branching involved in ureteric bud morphogenesis, cardiac muscle hypertrophy in response to stress, cardiac septum development, cell differentiation, cell population proliferation, cellular response to glucose stimulus, cellular response to transforming growth factor beta stimulus, developmental growth, embryonic digit morphogenesis, endocardial cell differentiation, endoderm development, endothelial cell activation, epithelial cell migration, epithelial to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, extrinsic apoptotic signaling pathway, female gonad development, female gonad morphogenesis, formation of anatomical boundary, gastrulation, gastrulation with mouth forming second, in utero embryonic development, interleukin-6-mediated signaling pathway, intracellular iron ion homeostasis, intracellular signal transduction, kidney development, left ventricular cardiac muscle tissue morphogenesis, male gonad development, mesendoderm development, mesoderm development, metanephric mesenchyme morphogenesis, negative regulation of DNA-templated transcription, negative regulation of ERK1 and ERK2 cascade, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle hypertrophy, negative regulation of cardiac myofibril assembly, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of protein catabolic process, negative regulation of transcription by RNA polymerase II, nephrogenic mesenchyme morphogenesis, neural crest cell differentiation, neuron fate commitment, neuron fate specification, osteoblast differentiation, outflow tract septum morphogenesis, ovarian follicle development, positive regulation of DNA-templated transcription, positive regulation of SMAD protein signal transduction, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cell proliferation involved in heart valve morphogenesis, positive regulation of epithelial to mesenchymal transition, positive regulation of extracellular matrix assembly, positive regulation of follicle-stimulating hormone secretion, positive regulation of gene expression, positive regulation of luteinizing hormone secretion, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of hair follicle development, regulation of macromolecule metabolic process, regulation of primary metabolic process, regulation of transcription by RNA polymerase II, regulation of transforming growth factor beta2 production, response to hypoxia, response to transforming growth factor beta, sebaceous gland development, secondary palate development, seminiferous tubule development, single fertilization, somite rostral/caudal axis specification, spermatogenesis, tissue morphogenesis, transforming growth factor beta receptor signaling pathway, ureteric bud development, uterus development, ventricular septum morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, I-SMAD binding, R-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, chromatin binding, collagen binding, filamin binding, identical protein binding, metal ion binding, protein binding, protein homodimerization activity, protein-containing complex binding, sequence-specific DNA binding, sulfate binding, transcription cis-regulatory region binding, transcription coactivator binding, transcription corepressor binding; CC: RNA polymerase II transcription regulator complex, SMAD protein complex, activin responsive factor complex, centrosome, chromatin, ciliary basal body, cytoplasm, cytosol, heteromeric SMAD protein complex, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adherens junction - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Cell cycle - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Deubiquitination, Developmental Biology, Downregulation of SMAD2/3:SMAD4 transcriptional activity, FOXO-mediated transcription, FOXO-mediated transcription of cell cycle genes, FoxO signaling pathway - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Hepatitis B - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Hippo signaling pathway - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Metabolism of proteins, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, RNA Polymerase II Transcription, RUNX2 regulates bone development, RUNX3 regulates CDKN1A transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by Activin, Signaling by BMP, Signaling by NODAL, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TGF-beta receptor signaling activates SMADs, TGF-beta signaling pathway - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Ub-specific processing proteases, Wnt signaling pathway - Mus musculus (mouse)
UniProt: P97471
Entrez ID: 17128
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cap2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Cap2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cap2 (cyclase associated actin cytoskeleton regulatory protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, cAMP-mediated signaling, cell morphogenesis, cytoskeleton organization, presynaptic actin cytoskeleton organization, regulation of modification of postsynaptic actin cytoskeleton; MF: actin binding, adenylate cyclase binding, identical protein binding; CC: cytoplasm, glutamatergic synapse, membrane, plasma membrane, postsynapse, postsynaptic density
Pathways:
UniProt: Q9CYT6
Entrez ID: 67252
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Wbp4
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Wbp4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Wbp4 (WW domain binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, metal ion binding, nucleic acid binding, proline-rich region binding, protein binding, zinc ion binding; CC: U2-type precatalytic spliceosome, nuclear speck, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q61048
Entrez ID: 22380
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Huwe1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Huwe1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Huwe1 (HECT, UBA and WWE domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, Golgi organization, base-excision repair, canonical NF-kappaB signal transduction, cell differentiation, chromatin remodeling, circadian regulation of gene expression, defense response to bacterium, membrane fusion, negative regulation of canonical NF-kappaB signal transduction, negative regulation of mitochondrial fusion, negative regulation of peroxisome proliferator activated receptor signaling pathway, peroxisome proliferator activated receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein ubiquitination, positive regulation of type 2 mitophagy, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein branched polyubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, rhythmic process, ubiquitin-dependent protein catabolic process; MF: DNA binding, histone ubiquitin ligase activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: Golgi membrane, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Innate Immune System, Neutrophil degranulation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q7TMY8
Entrez ID: 59026
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Smg7
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Smg7 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Smg7 (SMG7 nonsense mediated mRNA decay factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; MF: protein phosphatase 2A binding, telomerase RNA binding, telomeric DNA binding; CC: cytoplasm, cytosol, nucleus, telomerase holoenzyme complex
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q5RJH6
Entrez ID: 226517
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Aadac
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Aadac in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Aadac (arylacetamide deacetylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, positive regulation of triglyceride catabolic process; MF: carboxylic ester hydrolase activity, catalytic activity, deacetylase activity, hydrolase activity, lipase activity, serine hydrolase activity, triacylglycerol lipase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biological oxidations, Metabolism, Phase I - Functionalization of compounds
UniProt: Q99PG0
Entrez ID: 67758
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zbtb11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Zbtb11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zbtb11 (zinc finger and BTB domain containing 11)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in central nervous system; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 69. Orthologous to human ZBTB11 (zinc finger and BTB domain containing 11). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: G5E8B9
Entrez ID: 271377
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ttc39d
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Ttc39d in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ttc39d (tetratricopeptide repeat domain 39D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, negative regulation of cholesterol storage, regulation of cholesterol efflux, regulation of cholesterol metabolic process
Pathways:
UniProt: Q0VF76
Entrez ID: 67737
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Birc6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Birc6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Birc6 (baculoviral IAP repeat-containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, cell division, labyrinthine layer development, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, placenta development, positive regulation of cell population proliferation, protein ubiquitination, regulation of cell population proliferation, regulation of cytokinesis, spongiotrophoblast layer development; MF: cysteine-type endopeptidase inhibitor activity, metal ion binding, peptidase inhibitor activity, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity; CC: Flemming body, Golgi apparatus, centrosome, cytoplasm, cytoskeleton, endosome, membrane, microtubule organizing center, midbody, nucleus, spindle pole, trans-Golgi network
Pathways: Apoptosis - multiple species - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: O88738
Entrez ID: 12211
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Trappc4
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Trappc4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Trappc4 (trafficking protein particle complex 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: COPII vesicle coating, autophagy, dendrite development, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, Golgi stack, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, cytoplasm, dendrite, endoplasmic reticulum, membrane, plasma membrane, postsynaptic density membrane, postsynaptic membrane, presynaptic active zone, synapse, synaptic vesicle, vesicle
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9ES56
Entrez ID: 60409
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ogt
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Ogt in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ogt (O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, apoptotic process, cellular response to glucose stimulus, cellular response to lipopolysaccharide, cellular response to nutrient levels, chromatin organization, circadian regulation of gene expression, cytoplasmic translation, glucosamine metabolic process, hemopoiesis, intracellular distribution of mitochondria, membraneless organelle assembly, mitophagy, negative regulation of cell migration, negative regulation of cellular response to hypoxia, negative regulation of non-canonical inflammasome complex assembly, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein targeting to membrane, negative regulation of protein ubiquitination, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of translation, negative regulation of translational initiation, non-canonical inflammasome complex assembly, positive regulation of DNA-templated transcription, positive regulation of TORC1 signaling, positive regulation of cell size, positive regulation of cold-induced thermogenesis, positive regulation of gene expression, positive regulation of lipid biosynthetic process, positive regulation of protein localization to nucleus, positive regulation of proteolysis, positive regulation of reactive oxygen species biosynthetic process, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription from RNA polymerase II promoter by glucose, positive regulation of translation, positive regulation of translational initiation, protein O-linked glycosylation, protein glycosylation, protein localization to lysosome, protein maturation, protein processing, pyroptotic inflammatory response, regulation of Rac protein signal transduction, regulation of gluconeogenesis, regulation of glycolytic process, regulation of insulin receptor signaling pathway, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of protein localization to membrane, regulation of synapse assembly, regulation of transcription by RNA polymerase II, response to insulin, rhythmic process; MF: N-acetyltransferase activity, catalytic activity, chromatin DNA binding, glycosyltransferase activity, identical protein binding, lipid binding, peptide binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein O-acetylglucosaminyltransferase activity, protein binding, protein domain specific binding, protein-containing complex binding, transferase activity; CC: GABA-ergic synapse, NSL complex, Sin3-type complex, cell projection, cerebellar granule cell to Purkinje cell synapse, cytoplasm, cytosol, euchromatin, glutamatergic synapse, histone acetyltransferase complex, membrane, mitochondrial membrane, mitochondrion, neuronal cell body, nucleoplasm, nucleus, plasma membrane, postsynaptic cytosol, presynaptic cytosol, protein N-acetylglucosaminyltransferase complex, protein-containing complex, synapse, zymogen granule
Pathways: Insulin resistance - Mus musculus (mouse), Other types of O-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q8CGY8
Entrez ID: 108155
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gigyf2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Gigyf2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gigyf2 (GRB10 interacting GYF protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult locomotory behavior, feeding behavior, homeostasis of number of cells within a tissue, insulin-like growth factor receptor signaling pathway, mRNA destabilization, mitotic G1 DNA damage checkpoint signaling, multicellular organism growth, musculoskeletal movement, negative regulation of translation, negative regulation of translational initiation, negative regulation of type I interferon-mediated signaling pathway, neuromuscular process controlling balance, post-embryonic development, post-transcriptional gene silencing, rescue of stalled ribosome, spinal cord motor neuron differentiation; MF: molecular adaptor activity, proline-rich region binding, protein binding; CC: Golgi apparatus, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum, endosome, membrane, perikaryon, protein-containing complex, proximal dendrite, vesicle
Pathways:
UniProt: Q6Y7W8
Entrez ID: 227331
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rrm2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Rrm2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rrm2 (ribonucleotide reductase M2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 2'-deoxyribonucleotide biosynthetic process, blastocyst development, deoxyribonucleotide biosynthetic process, deoxyribonucleotide metabolic process, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of cell population proliferation, protein heterotetramerization, ribonucleoside diphosphate metabolic process; MF: ferric iron binding, identical protein binding, metal ion binding, oxidoreductase activity, protein binding, protein homodimerization activity, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; CC: cytoplasm, cytosol, nuclear envelope, nucleoplasm, nucleus, ribonucleoside-diphosphate reductase complex
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Glutathione metabolism - Mus musculus (mouse), Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), adenosine nucleotides <i>de novo</i> biosynthesis, p53 signaling pathway - Mus musculus (mouse), pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I
UniProt: P11157
Entrez ID: 20135
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Lztr1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Lztr1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Lztr1 (leucine-zipper-like transcriptional regulator, 1)
Type: protein-coding
Summary: This gene encodes a member of the BR-C, ttk and bab-kelch superfamily that, in humans, localizes to the Golgi network and is associated with the ras / mitogen-activated protein kinase pathway. Loss-of-function mutations in the human ortholog are associated with glioblastoma multiforme, schwannomatosis, Noonan syndrome, and DiGeorge syndrome. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: negative regulation of Ras protein signal transduction, protein ubiquitination; MF: small GTPase binding; CC: Cul3-RING ubiquitin ligase complex, Golgi apparatus, endomembrane system, endosome, membrane, recycling endosome, recycling endosome membrane
Pathways:
UniProt: Q9CQ33
Entrez ID: 66863
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zfp937
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Zfp937 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zfp937 (zinc finger protein 937)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF880 (zinc finger protein 880). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: A2ANU7
Entrez ID: 245174
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hira
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Hira in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hira (histone cell cycle regulator)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and histone binding activity. Predicted to contribute to nucleosome binding activity. Acts upstream of or within gastrulation; muscle cell differentiation; and osteoblast differentiation. Located in chromatin. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; limb bud; and sensory organ. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, chromatin organization, chromatin remodeling, gastrulation, muscle cell differentiation, nucleosome assembly, osteoblast differentiation, regulation of DNA-templated transcription; MF: RNA polymerase II-specific DNA-binding transcription factor binding, histone binding, histone chaperone activity, nucleosome binding, protein binding; CC: HIR complex, PML body, chromatin, nucleoplasm, nucleus, protein-containing complex
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, DNA Damage/Telomere Stress Induced Senescence, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
UniProt: Q61666
Entrez ID: 15260
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ccnf
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Ccnf in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ccnf (cyclin F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cell division, negative regulation of centrosome duplication, placenta development, protein ubiquitination, re-entry into mitotic cell cycle, regulation of cell cycle; MF: anaphase-promoting complex binding, cyclin-dependent protein serine/threonine kinase regulator activity; CC: SCF ubiquitin ligase complex, centriole, centrosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytoskeleton, microtubule organizing center, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: P51944
Entrez ID: 12449
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Meaf6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Meaf6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Meaf6 (MYST/Esa1-associated factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA biosynthetic process, regulation of DNA replication, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of cell growth, regulation of developmental process, regulation of double-strand break repair, regulation of hemopoiesis; MF: histone H3K14 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity; CC: MOZ/MORF histone acetyltransferase complex, NuA4 histone acetyltransferase complex, chromosome, chromosome, centromeric region, histone acetyltransferase complex, kinetochore, nucleolus, nucleoplasm, nucleosome, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Transcriptional Regulation by TP53
UniProt: Q2VPQ9
Entrez ID: 70088
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pold1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Pold1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pold1 (polymerase (DNA directed), delta 1, catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-templated DNA replication, base-excision repair, gap-filling, cellular response to UV, error-free translesion synthesis, fatty acid homeostasis, nucleotide-excision repair, DNA gap filling; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, catalytic activity, acting on a nucleic acid, chromatin binding, damaged DNA binding, enzyme binding, exonuclease activity, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, transferase activity, zinc ion binding; CC: aggresome, chromosome, telomeric region, cytosol, delta DNA polymerase complex, nucleoplasm, nucleotide-excision repair complex, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P52431
Entrez ID: 18971
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gps2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Gps2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gps2 (G protein pathway suppressor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, negative regulation of B cell receptor signaling pathway, negative regulation of JNK cascade, negative regulation of fat cell differentiation, negative regulation of inflammatory response, negative regulation of protein K63-linked ubiquitination, negative regulation of toll-like receptor signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of cholesterol efflux, positive regulation of peroxisome proliferator activated receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of fat cell differentiation, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II, response to mitochondrial depolarisation; MF: cyclin binding, protein binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), HDACs deacetylate histones, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q921N8
Entrez ID: 56310
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zc3h7b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Zc3h7b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zc3h7b (zinc finger CCCH type containing 7B)
Type: protein-coding
Summary: Predicted to enable miRNA binding activity. Predicted to be involved in miRNA processing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Orthologous to human ZC3H7B (zinc finger CCCH-type containing 7B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: miRNA processing, post-transcriptional regulation of gene expression; MF: metal ion binding, miRNA binding, zinc ion binding; CC: cellular_component, nucleus
Pathways:
UniProt: A0A2R8VHI0, F8VPP8
Entrez ID: 20286
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Snip1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Snip1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Snip1 (Smad nuclear interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, miRNA processing, negative regulation of canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulatory ncRNA-mediated gene silencing; MF: mRNA binding, transcription regulator inhibitor activity; CC: U2-type precatalytic spliceosome, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8BIZ6
Entrez ID: 76793
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nfib
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Nfib in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nfib (nuclear factor I/B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, anterior commissure morphogenesis, brain development, cell differentiation involved in salivary gland development, cell proliferation in forebrain, chondrocyte differentiation, club cell differentiation, commissural neuron axon guidance, exit from mitosis, forebrain development, gene expression, generation of neurons, glandular epithelial cell differentiation, glial cell differentiation, glial cell fate specification, glial cell proliferation, hindbrain development, lung ciliated cell differentiation, lung development, negative regulation of epithelial cell proliferation involved in lung morphogenesis, negative regulation of mesenchymal cell proliferation involved in lung development, negative regulation of miRNA transcription, negative regulation of stem cell proliferation, negative regulation of transcription by RNA polymerase II, neural precursor cell proliferation, neurogenesis, neuron fate specification, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, principal sensory nucleus of trigeminal nerve development, regeneration, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to bacterium, response to wounding, retina development in camera-type eye, salivary gland cavitation, stem cell population maintenance, tissue homeostasis, type I pneumocyte differentiation, type II pneumocyte differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, sequence-specific double-stranded DNA binding; CC: cerebellar mossy fiber, fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: P97863
Entrez ID: 18028
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Usp19
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Usp19 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Usp19 (ubiquitin specific peptidase 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, negative regulation of proteasomal protein catabolic process, negative regulation of skeletal muscle tissue development, positive regulation of cell cycle process, protein K48-linked deubiquitination, protein deubiquitination, protein stabilization, proteolysis, regulation of ERAD pathway, regulation of cellular response to hypoxia, regulation of protein stability, response to endoplasmic reticulum stress; MF: Hsp90 protein binding, K48-linked deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, protein binding, ubiquitin protein ligase binding, zinc ion binding; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q3UJD6
Entrez ID: 71472
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gbp10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Gbp10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gbp10 (guanylate-binding protein 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to lipopolysaccharide, cellular response to type II interferon, defense response to Gram-positive bacterium, defense response to protozoan, immune system process, innate immune response; MF: GTP binding, GTPase activity, hydrolase activity; CC: cytoplasmic vesicle
Pathways:
UniProt: Q000W5
Entrez ID: 626578
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ube2a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Ube2a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ube2a (ubiquitin-conjugating enzyme E2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, G2/M transition of mitotic cell cycle, blastocyst hatching, chromatin remodeling, in utero embryonic development, maternal process involved in female pregnancy, positive regulation of mitophagy, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein polyubiquitination, protein ubiquitination, response to UV; MF: ATP binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity; CC: HULC complex, XY body, chromatin, endosome, late endosome, lysosome
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, E3 ubiquitin ligases ubiquitinate target proteins, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9Z255
Entrez ID: 22209
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Lsm1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Lsm1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Lsm1 (LSM1 homolog, mRNA degradation associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, deadenylation-dependent decapping of nuclear-transcribed mRNA, histone mRNA catabolic process, mRNA processing, negative regulation of neuron differentiation, nuclear-transcribed mRNA catabolic process, stem cell population maintenance; MF: RNA binding, mRNA binding, pre-mRNA binding, protein binding; CC: Lsm1-7-Pat1 complex, P-body, axon, cytoplasm, dendrite, neuronal cell body, nucleus, ribonucleoprotein complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, RNA degradation - Mus musculus (mouse), mRNA decay by 5' to 3' exoribonuclease
UniProt: Q8VC85
Entrez ID: 67207
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Lpgat1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Lpgat1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Lpgat1 (lysophosphatidylglycerol acyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, phosphatidylethanolamine acyl-chain remodeling, phosphatidylinositol acyl-chain remodeling, phospholipid biosynthetic process, positive regulation of fatty acid biosynthetic process, triglyceride biosynthetic process; MF: 2-acylglycerol O-acyltransferase activity, 2-acylglycerophosphocholine O-acyltransferase activity, acyltransferase activity, lysophosphatidylethanolamine acyltransferase activity, lysophospholipid acyltransferase activity, transferase activity; CC: cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Acyl chain remodelling of PG, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Phospholipid metabolism
UniProt: Q91YX5
Entrez ID: 226856
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cbl
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Cbl in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cbl (Casitas B-lineage lymphoma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, bone resorption, cell surface receptor signaling pathway, cellular response to hypoxia, cellular response to nerve growth factor stimulus, cellular response to platelet-derived growth factor stimulus, male gonad development, mast cell degranulation, negative regulation of apoptotic process, negative regulation of epidermal growth factor receptor signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of receptor-mediated endocytosis, protein autoubiquitination, protein monoubiquitination, protein phosphorylation, protein polyubiquitination, protein ubiquitination, regulation of Rap protein signal transduction, regulation of intracellular signal transduction, regulation of platelet-derived growth factor receptor-alpha signaling pathway, regulation of signaling, response to activity, response to ethanol, response to gamma radiation, response to starvation, response to testosterone, signal transduction, ubiquitin-dependent endocytosis, ubiquitin-dependent protein catabolic process; MF: SH3 domain binding, calcium ion binding, ephrin receptor binding, metal ion binding, phosphatidylinositol 3-kinase regulatory subunit binding, phosphotyrosine residue binding, protein binding, protein kinase binding, protein tyrosine kinase binding, receptor tyrosine kinase binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Golgi apparatus, axon, cell projection, cilium, cytoplasm, cytosol, flotillin complex, focal adhesion, growth cone, membrane, membrane raft, perinuclear region of cytoplasm, plasma membrane
Pathways: Bacterial invasion of epithelial cells - Mus musculus (mouse), Cargo recognition for clathrin-mediated endocytosis, Chronic myeloid leukemia - Mus musculus (mouse), Clathrin-mediated endocytosis, Cytokine Signaling in Immune system, EGFR downregulation, Endocytosis - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), FLT3 Signaling, Immune System, Insulin signaling pathway - Mus musculus (mouse), Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-6 family signaling, Interleukin-6 signaling, Membrane Trafficking, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of FLT3, Negative regulation of MET activity, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Pathways in cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Regulation of KIT signaling, Regulation of signaling by CBL, Signal Transduction, Signaling by EGFR, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Interleukins, Signaling by MET, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Spry regulation of FGF signaling, TGF-beta receptor signaling activates SMADs, Ubiquitin mediated proteolysis - Mus musculus (mouse), Vesicle-mediated transport
UniProt: P22682
Entrez ID: 12402
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cwc27
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Cwc27 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cwc27 (CWC27 spliceosome-associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein folding; CC: U2-type precatalytic spliceosome, catalytic step 2 spliceosome, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q3TKY6
Entrez ID: 67285
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rnf40
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Rnf40 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rnf40 (ring finger protein 40)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, positive regulation of proteasomal protein catabolic process, positive regulation of protein polyubiquitination, positive regulation of transcription by RNA polymerase II, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: mRNA 3'-UTR binding, metal ion binding, protein binding, protein homodimerization activity, syntaxin-1 binding, transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: HULC complex, nucleoplasm, nucleus, protein-containing complex, ubiquitin ligase complex
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination
UniProt: Q3U319
Entrez ID: 233900
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mitd1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Mitd1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mitd1 (MIT, microtubule interacting and transport, domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, midbody abscission, mitotic cytokinesis; MF: identical protein binding, phosphatidylinositol binding, protein domain specific binding; CC: endosome, late endosome membrane, membrane, midbody
Pathways:
UniProt: Q8VDV8
Entrez ID: 69028
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mier3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Mier3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mier3 (MIER family member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: histone deacetylase binding, transcription corepressor activity; CC: nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q3UHF3
Entrez ID: 218613
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zfx
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Zfx in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zfx (zinc finger protein X-linked)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin insulator sequence binding activity. Acts upstream of or within several processes, including oocyte development; ovarian follicle development; and parental behavior. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be active in chromosome. Is expressed in several structures, including 4-cell stage embryo; central nervous system; genitourinary system; ileum; and spleen. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human ZFX (zinc finger protein X-linked). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: fertilization, germ cell development, homeostasis of number of cells, multicellular organism growth, oocyte development, ovarian follicle development, parental behavior, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin insulator sequence binding, metal ion binding, zinc ion binding; CC: chromatin, chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: P17012
Entrez ID: 22764
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Chek1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Chek1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Chek1 (checkpoint kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, G2/M transition of mitotic cell cycle, apoptotic process, apoptotic process involved in development, cellular response to mechanical stimulus, chromatin remodeling, inner cell mass cell proliferation, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, mitotic nuclear membrane disassembly, negative regulation of DNA biosynthetic process, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of cell cycle phase transition, negative regulation of gene expression, epigenetic, negative regulation of mitotic nuclear division, nuclear envelope organization, nucleus organization, peptidyl-threonine phosphorylation, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell cycle, regulation of cell population proliferation, regulation of double-strand break repair via homologous recombination, regulation of gene expression, regulation of mitotic centrosome separation, signal transduction in response to DNA damage; MF: ATP binding, histone H3T11 kinase activity, kinase activity, nucleotide binding, protein binding, protein domain specific binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, chromatin, chromosome, chromosome, telomeric region, condensed nuclear chromosome, cytoplasm, cytoskeleton, nucleoplasm, nucleus, protein-containing complex, replication fork
Pathways: Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), DNA Double-Strand Break Repair, DNA Repair, G1/S DNA Damage Checkpoints, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Transcriptional Regulation by E2F6, Transcriptional Regulation by TP53, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Viral carcinogenesis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse), p53-Independent G1/S DNA Damage Checkpoint
UniProt: O35280
Entrez ID: 12649
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Otud5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Otud5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Otud5 (OTU domain containing 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, alpha-beta T cell differentiation, T-helper 17 cell lineage commitment, cell differentiation, negative regulation of canonical Wnt signaling pathway, negative regulation of cytokine production, negative regulation of interleukin-17 production, neural crest cell differentiation, positive regulation of TORC1 signaling, positive regulation of TORC2 signaling, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked deubiquitination, protein K63-linked deubiquitination, protein deubiquitination, proteolysis, regulation of T-helper 17 type immune response, regulation of immune response, regulation of protein stability, response to lipopolysaccharide; MF: K48-linked deubiquitinase activity, K63-linked deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, peptidase activity, protein binding; CC: nucleus
Pathways: RIG-I-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q3U2S4
Entrez ID: 54644
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Kpna2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Kpna2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Kpna2 (karyopherin subunit alpha 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, entry of viral genome into host nucleus through nuclear pore complex via importin, non-canonical NF-kappaB signal transduction, positive regulation of DNA-templated transcription, positive regulation of type I interferon production, positive regulation of viral life cycle, postsynapse to nucleus signaling pathway, protein import into nucleus, protein transport, regulation of transcription by glucose; MF: DNA-binding transcription factor binding, histone deacetylase binding, nuclear import signal receptor activity, nuclear localization sequence binding, protein binding; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytoplasmic stress granule, cytosol, glutamatergic synapse, host cell, nuclear membrane, nucleoplasm, nucleus, postsynaptic density
Pathways: Chemical carcinogenesis - receptor activation - Mus musculus (mouse), DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Influenza A - Mus musculus (mouse), Nucleocytoplasmic transport - Mus musculus (mouse), Sensing of DNA Double Strand Breaks
UniProt: P52293
Entrez ID: 16647
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ranbp9
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Ranbp9 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ranbp9 (RAN binding protein 9)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in cytoskeleton organization and negative regulation of ERK1 and ERK2 cascade. Located in cytoplasm. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and palatal shelf. Orthologous to human RANBP9 (RAN binding protein 9). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoskeleton organization, negative regulation of ERK1 and ERK2 cascade, positive regulation of amyloid precursor protein catabolic process; MF: enzyme binding, protein binding, small GTPase binding; CC: cytoplasm, cytosol, membrane, nuclear body, nucleoplasm, nucleus, plasma membrane, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Axon guidance, Developmental Biology, L1CAM interactions, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MET activates RAS signaling, Metabolism, Nervous system development, Pyruvate metabolism, RAF/MAP kinase cascade, Regulation of pyruvate metabolism, Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: P69566
Entrez ID: 56705
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Hdac8
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Hdac8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Hdac8 (histone deacetylase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to forskolin, cellular response to trichostatin A, chromatin organization, heterochromatin formation, mitotic sister chromatid cohesion, negative regulation of gene expression, negative regulation of osteoblast differentiation, negative regulation of protein ubiquitination, regulation of protein stability, regulation of telomere maintenance, response to 11-deoxycorticosterone; MF: DNA-binding transcription factor binding, Hsp70 protein binding, Hsp90 protein binding, chromatin binding, deacetylase activity, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, histone decrotonylase activity, hydrolase activity, metal ion binding, protein decrotonylase activity, protein lysine deacetylase activity; CC: chromosome, cytoplasm, histone deacetylase complex, nucleus
Pathways: Alcoholism - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Neutrophil extracellular trap formation - Mus musculus (mouse), Notch-HLH transcription pathway, RNA Polymerase II Transcription, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q8VH37
Entrez ID: 70315
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Brap
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Brap in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Brap (BRCA1 associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, Ras protein signal transduction, negative regulation of signal transduction, protein ubiquitination; MF: identical protein binding, metal ion binding, nuclear localization sequence binding, nucleic acid binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nuclear membrane, nucleoplasm, ubiquitin ligase complex
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, RAF activation, RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Signal Transduction
UniProt: Q99MP8
Entrez ID: 72399
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tfpt
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Tfpt in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tfpt (TCF3 (E2A) fusion partner)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, apoptotic process, apoptotic signaling pathway, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, telomere maintenance; MF: DNA binding, protein kinase binding, protein-containing complex binding; CC: Ino80 complex, actin filament, cytoplasm, nucleoplasm, nucleus
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q3U1J1
Entrez ID: 69714
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nosip
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Nosip in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nosip (nitric oxide synthase interacting protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein ubiquitination, regulation of nitric oxide biosynthetic process; MF: molecular sequestering activity, transferase activity, ubiquitin protein ligase activity; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism, Metabolism of nitric oxide: NOS3 activation and regulation, NOSIP mediated eNOS trafficking, citrulline-nitric oxide cycle, superpathway of citrulline metabolism
UniProt: Q9D6T0
Entrez ID: 66394
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ubr5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Ubr5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ubr5 (ubiquitin protein ligase E3 component n-recognin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, cytoplasm protein quality control, cytoplasm protein quality control by the ubiquitin-proteasome system, estrogen receptor signaling pathway, heterochromatin boundary formation, negative regulation of interleukin-17 production, negative regulation of smoothened signaling pathway, nuclear protein quality control by the ubiquitin-proteasome system, positive regulation of canonical Wnt signaling pathway, positive regulation of gene expression, positive regulation of protein import into nucleus, progesterone receptor signaling pathway, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein polyubiquitination, protein ubiquitination, regulation of protein stability, response to oxidative stress, retinoic acid receptor signaling pathway, ubiquitin-dependent protein catabolic process via the N-end rule pathway, vitamin D receptor signaling pathway; MF: RNA binding, metal ion binding, protein binding, protein domain specific binding, transferase activity, ubiquitin binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q80TP3
Entrez ID: 70790
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cadm1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Cadm1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cadm1 (cell adhesion molecule 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, bone development, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, cell differentiation, cell recognition, detection of stimulus, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, homophilic cell adhesion via plasma membrane adhesion molecules, immune system process, liver development, lymphocyte migration into lymphoid organs, maintenance of postsynaptic specialization structure, negative regulation of ERBB4 signaling pathway, positive regulation of cytokine production, positive regulation of natural killer cell mediated cytotoxicity, presynapse assembly, retrograde trans-synaptic signaling by trans-synaptic protein complex, spermatogenesis, susceptibility to natural killer cell mediated cytotoxicity, synapse assembly, synaptic membrane adhesion, unidimensional cell growth; MF: PDZ domain binding, cell adhesion molecule binding, protein binding, protein homodimerization activity, signaling receptor binding; CC: Schaffer collateral - CA1 synapse, axon, basolateral plasma membrane, cell body fiber, cell-cell junction, dendrite, glutamatergic synapse, membrane, neuron projection, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic membrane, synapse, synaptic membrane, synaptic vesicle, varicosity
Pathways: Adherens junctions interactions, Cell adhesion molecules - Mus musculus (mouse), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Nectin/Necl trans heterodimerization
UniProt: Q8R5M8
Entrez ID: 54725
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Maea
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Maea in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Maea (macrophage erythroblast attacher)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell division, cytoskeleton organization, enucleate erythrocyte development, erythrocyte development, erythrocyte maturation, negative regulation of myeloid cell apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: actin binding, metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: GID complex, actin cytoskeleton, actomyosin contractile ring, cytoplasm, cytoskeleton, membrane, nuclear matrix, nucleoplasm, nucleus, plasma membrane, spindle, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q4VC33
Entrez ID: 59003
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Kpnb1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Kpnb1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Kpnb1 (karyopherin subunit beta 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NLS-bearing protein import into nucleus, RNA import into nucleus, astral microtubule organization, establishment of mitotic spindle localization, intracellular protein transport, mitotic chromosome movement towards spindle pole, mitotic metaphase chromosome alignment, mitotic spindle assembly, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, positive regulation of cholesterol biosynthetic process, positive regulation of hippo signaling, protein import into nucleus, protein transport, ribosomal protein import into nucleus; MF: Hsp90 protein binding, enzyme binding, importin-alpha family protein binding, kinesin binding, nuclear import signal receptor activity, nuclear localization sequence binding, protein binding, protein domain specific binding, protein-containing complex binding, small GTPase binding; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum tubular network, nuclear envelope, nuclear membrane, nuclear pore, nucleoplasm, nucleus, protein-containing complex
Pathways: Apoptosis, Apoptosis induced DNA fragmentation, Apoptotic execution phase, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Immune System, Initiation of Nuclear Envelope (NE) Reformation, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, M Phase, Metabolism, Metabolism of lipids, Metabolism of steroids, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Neutrophil degranulation, Nuclear Envelope (NE) Reassembly, Nucleocytoplasmic transport - Mus musculus (mouse), Programmed Cell Death, Regulation of cholesterol biosynthesis by SREBP (SREBF)
UniProt: P70168
Entrez ID: 16211
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nprl2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Nprl2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nprl2 (NPR2 like, GATOR1 complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid starvation, cellular response to methionine, cellular response to nutrient levels, cytoplasmic translation, negative regulation of TORC1 signaling, negative regulation of translational initiation, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of translational initiation, protein localization to lysosome; MF: GTPase activator activity; CC: GATOR1 complex, lysosomal membrane, lysosome, membrane, vacuolar membrane
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9WUE4
Entrez ID: 56032
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ezh2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Ezh2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit)
Type: protein-coding
Summary: Enables several functions, including DNA binding activity; RNA binding activity; and transcription corepressor activity. Involved in B cell differentiation; facultative heterochromatin formation; and regulation of circadian rhythm. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; negative regulation of cell differentiation; and regulation of DNA-templated transcription. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell differentiation, DNA methylation-dependent constitutive heterochromatin formation, G1 to G0 transition, cardiac muscle hypertrophy in response to stress, cellular response to hydrogen peroxide, cellular response to trichostatin A, cerebellar cortex development, chromatin organization, chromatin remodeling, constitutive heterochromatin formation, facultative heterochromatin formation, hemopoiesis, hepatocyte homeostasis, heterochromatin formation, hippocampus development, immunoglobulin heavy chain V-D-J recombination, liver regeneration, methylation, negative regulation of DNA-templated transcription, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of cytokine production involved in inflammatory response, negative regulation of epidermal cell differentiation, negative regulation of gene expression, negative regulation of gene expression, epigenetic, negative regulation of keratinocyte differentiation, negative regulation of retinoic acid receptor signaling pathway, negative regulation of stem cell differentiation, negative regulation of striated muscle cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of GTPase activity, positive regulation of MAP kinase activity, positive regulation of cell cycle G1/S phase transition, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of dendrite development, positive regulation of epithelial to mesenchymal transition, positive regulation of protein serine/threonine kinase activity, protein localization to chromatin, regulation of cell population proliferation, regulation of circadian rhythm, regulation of gene expression, regulation of gliogenesis, regulation of kidney development, regulation of neurogenesis, regulation of transcription by RNA polymerase II, regulatory ncRNA-mediated heterochromatin formation, response to estradiol, response to tetrachloromethane, rhythmic process, skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration, subtelomeric heterochromatin formation, synaptic transmission, GABAergic; MF: DNA binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, chromatin DNA binding, chromatin binding, histone H3K27 methyltransferase activity, histone H3K27 trimethyltransferase activity, histone binding, histone methyltransferase activity, lncRNA binding, methyltransferase activity, nucleosome binding, primary miRNA binding, promoter-specific chromatin binding, protein binding, protein-lysine N-methyltransferase activity, ribonucleoprotein complex binding, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription corepressor activity, transcription corepressor binding, transferase activity; CC: ESC/E(Z) complex, chromatin, chromatin silencing complex, chromosomal region, chromosome, chromosome, telomeric region, heterochromatin, nucleoplasm, nucleus, pericentric heterochromatin, pronucleus, synapse
Pathways: Lysine degradation - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse)
UniProt: Q61188
Entrez ID: 14056
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Zfp36l2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Zfp36l2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Zfp36l2 (zinc finger protein 36, C3H type-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, ERK1 and ERK2 cascade, MAPK cascade, T cell differentiation in thymus, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to glucocorticoid stimulus, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, definitive hemopoiesis, hemopoiesis, mRNA catabolic process, negative regulation of fat cell differentiation, negative regulation of mitotic cell cycle phase transition, negative regulation of stem cell differentiation, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, regulation of B cell differentiation, regulation of mRNA stability, response to wounding, somatic stem cell division, somatic stem cell population maintenance; MF: RNA binding, mRNA 3'-UTR AU-rich region binding, mRNA binding, metal ion binding, zinc ion binding; CC: cytoplasm, cytosol, nucleus, ribonucleoprotein complex
Pathways: Cellular senescence - Mus musculus (mouse)
UniProt: P23949
Entrez ID: 12193
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rest
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Rest in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rest (RE1-silencing transcription factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: auditory receptor cell stereocilium organization, cardiac muscle cell myoblast differentiation, cellular response to electrical stimulus, cellular response to glucocorticoid stimulus, cellular response to stress, chromatin remodeling, detection of mechanical stimulus involved in sensory perception of sound, hematopoietic progenitor cell differentiation, host-mediated suppression of viral transcription, modification of synaptic structure, negative regulation of DNA-templated transcription, negative regulation of aldosterone biosynthetic process, negative regulation of amniotic stem cell differentiation, negative regulation of calcium ion-dependent exocytosis, negative regulation of cortisol biosynthetic process, negative regulation of dense core granule biogenesis, negative regulation of gene expression, negative regulation of insulin secretion, negative regulation of mesenchymal stem cell differentiation, negative regulation of miRNA transcription, negative regulation of neurogenesis, negative regulation of neuron differentiation, negative regulation of transcription by RNA polymerase II, nervous system process, neuromuscular process controlling balance, neuronal stem cell population maintenance, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of neuron differentiation, positive regulation of programmed cell death, positive regulation of stem cell population maintenance, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome, regulation of gene expression, regulation of osteoblast differentiation, response to hypoxia, response to ischemia, response to stress, somatic stem cell population maintenance; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, identical protein binding, metal ion binding, promoter-specific chromatin binding, protein binding, protein-containing complex binding, sequence-specific DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, protein-containing complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HDACs deacetylate histones, Huntington disease - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: Q8VIG1
Entrez ID: 19712
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Lig1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Lig1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Lig1 (ligase I, DNA, ATP-dependent)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA recombination, DNA repair, DNA replication, Okazaki fragment processing involved in mitotic DNA replication, base-excision repair, cell division, double-strand break repair via nonhomologous end joining, lagging strand elongation, response to hydrogen peroxide; MF: ATP binding, DNA binding, DNA ligase (ATP) activity, DNA ligase activity, ligase activity, metal ion binding, nucleotide binding; CC: nucleoplasm, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in TC-NER, Lagging Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, POLB-Dependent Long Patch Base Excision Repair, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Transcription-Coupled Nucleotide Excision Repair (TC-NER)
UniProt: P37913
Entrez ID: 16881
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sf3b5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Sf3b5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sf3b5 (splicing factor 3b, subunit 5)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and splicing factor binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U12-type spliceosomal complex; U2 snRNP; and U2-type precatalytic spliceosome. Is expressed in embryo; midbrain ventricular layer; olfactory cortex ventricular layer; orbito-sphenoid; and telencephalon ventricular layer. Orthologous to human SF3B5 (splicing factor 3b subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: RNA binding, splicing factor binding; CC: SAGA complex, U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q923D4
Entrez ID: 66125
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rnf146
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Rnf146 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rnf146 (ring finger protein 146)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, cellular response to hydrogen peroxide, negative regulation of cellular response to oxidative stress, positive regulation of canonical Wnt signaling pathway, protein K48-linked ubiquitination, protein autoubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: enzyme binding, metal ion binding, poly-ADP-D-ribose binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways: Degradation of AXIN, Deubiquitination, Intracellular signaling by second messengers, Metabolism of proteins, PIP3 activates AKT signaling, PTEN Regulation, Post-translational protein modification, Regulation of PTEN stability and activity, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Ub-specific processing proteases
UniProt: Q9CZW6
Entrez ID: 68031
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cyp51
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Cyp51 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cyp51 (cytochrome P450, family 51)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via 24,25-dihydrolanosterol, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, lipid metabolic process, negative regulation of amyloid-beta clearance, negative regulation of protein catabolic process, negative regulation of protein secretion, positive regulation of oocyte development, response to human chorionic gonadotropin, response to insulin, response to lead ion, spermatogenesis, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, zymosterol biosynthetic process; MF: heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, sterol 14-demethylase activity; CC: acrosomal vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biological oxidations, Cholesterol biosynthesis, Cytochrome P450 - arranged by substrate type, Endogenous sterols, Metabolism, Metabolism of lipids, Metabolism of steroids, Phase I - Functionalization of compounds, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, cholesterol biosynthesis III (via desmosterol), superpathway of cholesterol biosynthesis
UniProt: Q8K0C4
Entrez ID: 13121
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tsc2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Tsc2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tsc2 (TSC complex subunit 2)
Type: protein-coding
Summary: Enables 14-3-3 protein binding activity and GTPase activator activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several processes, including intracellular protein transport; negative regulation of lymphocyte proliferation; and regulation of signal transduction. Located in cytoplasm. Part of TSC1-TSC2 complex. Is active in lysosomal membrane and synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: D-glucose import, TORC1 signaling, anoikis, cell projection organization, cellular response to insulin stimulus, cellular response to nutrient levels, cellular response to starvation, connective tissue replacement, cytoplasmic translation, establishment of cell polarity, excitatory chemical synaptic transmission, heart development, inhibitory chemical synaptic transmission, intracellular protein localization, kidney development, myofibroblast differentiation, negative regulation of B cell proliferation, negative regulation of T cell proliferation, negative regulation of TOR signaling, negative regulation of TORC1 signaling, negative regulation of Wnt signaling pathway, negative regulation of axonogenesis, negative regulation of cell population proliferation, negative regulation of cell size, negative regulation of epithelial cell proliferation, negative regulation of epithelial to mesenchymal transition, negative regulation of fibroblast proliferation, negative regulation of insulin receptor signaling pathway, negative regulation of macroautophagy, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of pinocytosis, negative regulation of translational initiation, negative regulation of vascular endothelial cell proliferation, neural tube closure, positive chemotaxis, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of cell adhesion, positive regulation of dendritic spine development, positive regulation of fibroblast migration, positive regulation of insulin receptor signaling pathway, positive regulation of macroautophagy, positive regulation of neuron projection development, positive regulation of transcription by RNA polymerase II, positive regulation of translational initiation, protein import into nucleus, protein localization to cell surface, protein transport into plasma membrane raft, proximal tubule development, regulation of cell cycle, regulation of endocytosis, regulation of insulin receptor signaling pathway, regulation of macroautophagy, regulation of postsynapse organization, regulation of small GTPase mediated signal transduction, response to hypoxia, social behavior, tissue remodeling; MF: 14-3-3 protein binding, GTPase activator activity, Hsp90 protein binding, phosphatase binding, protein binding, protein homodimerization activity, protein-containing complex binding, small GTPase binding; CC: Golgi apparatus, TSC1-TSC2 complex, caveola, cell projection, cytoplasm, cytosol, dendrite, glutamatergic synapse, growth cone, lysosomal membrane, lysosome, membrane, neuronal cell body, nucleus, perinuclear region of cytoplasm, postsynaptic density, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q3UHB2, Q7TT21, Q3TQ10, A0A2I3BRT5, Q3UGI8, A0A2I3BPP1, Q3UG88, A0A2I3BPR7, A0A2I3BRA1, A0A2I3BPE9
Entrez ID: 22084
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Vcpip1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Vcpip1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Vcpip1 (valosin containing protein (p97)/p47 complex interacting protein 1)
Type: protein-coding
Summary: This gene encodes a deubiquitinating enzyme that interacts with valosin containing protein p97 and plays a role in the assembly of Golgi apparatus during mitosis. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: DNA damage response, DNA repair, Golgi organization, Golgi reassembly, endoplasmic reticulum membrane fusion, protein K11-linked deubiquitination, protein K48-linked deubiquitination, protein deubiquitination, protein ubiquitination, protein-DNA covalent cross-linking repair, proteolysis, regulation of protein localization to chromatin; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: Golgi apparatus, Golgi stack, cytoplasm, endoplasmic reticulum, nucleus, synapse
Pathways: Deubiquitination, Metabolism of proteins, Ovarian tumor domain proteases, Post-translational protein modification
UniProt: Q8CDG3
Entrez ID: 70675
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Abcc1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Abcc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Abcc1 (ATP-binding cassette, sub-family C member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: NK T cell activation, amygdala development, amyloid-beta clearance, amyloid-beta metabolic process, antigen processing and presentation of lipid antigen via MHC class Ib, astrocyte differentiation, bilirubin transport, blood vessel diameter maintenance, carboxylic acid transmembrane transport, cell chemotaxis, cell redox homeostasis, cellular response to amyloid-beta, cellular response to type II interferon, cobalamin transport, cyclic nucleotide transport, defense response to Gram-positive bacterium, endothelial cell apoptotic process, endothelium development, establishment of localization in cell, exploration behavior, export across plasma membrane, export from cell, gene expression, glial cell differentiation, glucocorticoid metabolic process, glutathione metabolic process, glutathione transmembrane transport, granuloma formation, hippocampus development, hydrogen peroxide biosynthetic process, immune response, inflammatory response, inflammatory response to antigenic stimulus, intracellular chemical homeostasis, intracellular nitrogen homeostasis, leukotriene biosynthetic process, leukotriene metabolic process, leukotriene transport, lipid transport, long-chain fatty acid import across plasma membrane, lymphocyte migration, macrophage activation, memory, multicellular organism growth, neural tissue regeneration, neurogenesis, phospholipid efflux, phospholipid translocation, pigment accumulation, positive regulation of cell migration, positive regulation of inflammatory response, protein localization to cell surface, reactive oxygen species biosynthetic process, regulation of cellular response to drug, regulation of membrane potential, response to fluid shear stress, response to glucocorticoid, response to oxidative stress, response to toxic substance, response to type II interferon, response to xenobiotic stimulus, sphingolipid translocation, superoxide anion generation, tissue homeostasis, transepithelial transport, transmembrane transport, xenobiotic detoxification by transmembrane export across the plasma membrane, xenobiotic transmembrane transport, xenobiotic transport, xenobiotic transport across blood-brain barrier; MF: ABC-type glutathione S-conjugate transporter activity, ABC-type transporter activity, ABC-type vitamin B12 transporter activity, ABC-type xenobiotic transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled carboxylic acid transmembrane transporter activity, ATPase-coupled lipid transmembrane transporter activity, amide transmembrane transporter activity, bilirubin transmembrane transporter activity, carboxylic acid transmembrane transporter activity, efflux transmembrane transporter activity, glutathione transmembrane transporter activity, hydrolase activity, long-chain fatty acid transmembrane transporter activity, nucleotide binding, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: apical plasma membrane, basal plasma membrane, basolateral plasma membrane, lateral plasma membrane, membrane, plasma membrane
Pathways: ABC transporters - Mus musculus (mouse), ABC-family proteins mediated transport, Arachidonate metabolism, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cobalamin (Cbl, vitamin B12) transport and metabolism, Cytoprotection by HMOX1, Drug ADME, Fatty acid metabolism, Heme degradation, Metabolism, Metabolism of lipids, Metabolism of porphyrins, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, MicroRNAs in cancer - Mus musculus (mouse), Paracetamol ADME, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid signaling pathway - Mus musculus (mouse), Synthesis of Leukotrienes (LT) and Eoxins (EX), Transport of RCbl within the body, Transport of small molecules, Vitamin digestion and absorption - Mus musculus (mouse)
UniProt: O35379
Entrez ID: 17250
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ube2h
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Ube2h in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ube2h (ubiquitin-conjugating enzyme E2H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, nucleotide binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P62257
Entrez ID: 22214
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gid8
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Gid8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gid8 (GID complex subunit 8)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; CC: cell junction, cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q9D7M1
Entrez ID: 76425
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nprl3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Nprl3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nprl3 (nitrogen permease regulator-like 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta morphogenesis, cardiac muscle tissue development, cellular response to amino acid starvation, negative regulation of TOR signaling, negative regulation of TORC1 signaling, positive regulation of autophagy, roof of mouth development, ventricular septum development; CC: GATOR1 complex, lysosomal membrane, lysosome, membrane
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8VIJ8
Entrez ID: 17168
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Upf1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Upf1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Upf1 (UPF1 RNA helicase and ATPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, DNA repair, DNA replication, cell cycle phase transition, cellular response to interleukin-1, cellular response to lipopolysaccharide, histone mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of mRNA catabolic process, positive regulation of mRNA cis splicing, via spliceosome, positive regulation of mRNA metabolic process, random inactivation of X chromosome, regulation of gene expression, regulation of telomere maintenance, regulation of translational termination, telomere maintenance via semi-conservative replication; MF: ATP binding, ATP hydrolysis activity, DNA binding, RNA binding, RNA helicase activity, chromatin binding, double-stranded DNA helicase activity, helicase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein-containing complex binding, telomeric DNA binding, zinc ion binding; CC: P-body, chromatin, chromosome, telomeric region, cytoplasm, cytosol, exon-exon junction complex, nucleoplasm, nucleus, perinuclear region of cytoplasm, supraspliceosomal complex
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q9EPU0
Entrez ID: 19704
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Usp18
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Usp18 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Usp18 (ubiquitin specific peptidase 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, negative regulation of type I interferon-mediated signaling pathway, protein deubiquitination, proteolysis, regulation of inflammatory response, regulation of protein stability, response to bacterium, response to other organism, response to stilbenoid; MF: ISG15-specific peptidase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, molecular adaptor activity, peptidase activity, protein binding; CC: cytosol, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Deubiquitination, ISG15 antiviral mechanism, Immune System, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Post-translational protein modification, Regulation of IFNA/IFNB signaling, Regulation of NF-kappa B signaling, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ub-specific processing proteases
UniProt: Q9WTV6
Entrez ID: 24110
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Morf4l1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Morf4l1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Morf4l1 (mortality factor 4 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell population proliferation, chromatin organization, chromatin remodeling, double-strand break repair via homologous recombination, fibroblast proliferation, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair; MF: chromatin binding, protein binding; CC: NuA4 histone acetyltransferase complex, Sin3-type complex, nuclear speck, nucleosome, nucleus
Pathways:
UniProt: P60762
Entrez ID: 21761
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Trip12
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Trip12 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Trip12 (thyroid hormone receptor interactor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, heterochromatin boundary formation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of embryonic development, ubiquitin-dependent protein catabolic process; MF: nuclear thyroid hormone receptor binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: G5E870
Entrez ID: 14897
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Upf2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Upf2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Upf2 (UPF2 regulator of nonsense transcripts homolog (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ regeneration, liver development, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, response to unfolded protein; MF: RNA binding, telomeric DNA binding; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, exon-exon junction complex, nucleus, perinuclear region of cytoplasm
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nucleocytoplasmic transport - Mus musculus (mouse), mRNA surveillance pathway - Mus musculus (mouse)
UniProt: A2AT37
Entrez ID: 326622
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sumo2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Sumo2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sumo2 (small ubiquitin-like modifier 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, protein sumoylation; MF: SUMO transferase activity, nuclear retinoid X receptor binding, protein binding, protein tag activity, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding; CC: GABA-ergic synapse, PML body, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, nucleoplasm, nucleus, postsynapse, postsynaptic cytosol, presynapse, presynaptic cytosol
Pathways: DNA Double-Strand Break Repair, DNA Repair, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Nucleocytoplasmic transport - Mus musculus (mouse), Nucleotide Excision Repair, Post-translational protein modification, Processing and activation of SUMO, Processing of DNA double-strand break ends, SUMO E3 ligases SUMOylate target proteins, SUMO is proteolytically processed, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of intracellular receptors, SUMOylation of transcription cofactors, SUMOylation of transcription factors, Vitamin D (calciferol) metabolism
UniProt: P61957
Entrez ID: 170930
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Wdr26
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Wdr26 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Wdr26 (WD repeat domain 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: GID complex, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q8C6G8
Entrez ID: 226757
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cdyl
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Cdyl in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cdyl (chromodomain protein, Y chromosome-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of peptidyl-lysine crotonylation, random inactivation of X chromosome, spermatid development, spermatogenesis; MF: acyltransferase activity, chromatin binding, crotonyl-CoA hydratase activity, histone acetyltransferase activity, identical protein binding, lyase activity, protein binding, protein-lysine-acetyltransferase activity, protein-macromolecule adaptor activity, transcription corepressor activity, transferase activity; CC: chromosome, cytoplasm, nuclear speck, nucleus
Pathways:
UniProt: Q9WTK2
Entrez ID: 12593
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Spop
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Spop in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Spop (speckle-type BTB/POZ protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: glucose homeostasis, negative regulation of transcription by RNA polymerase II, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of type B pancreatic cell apoptotic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of proteolysis, ubiquitin-dependent protein catabolic process; MF: RNA polymerase II-specific DNA-binding transcription factor binding, identical protein binding, molecular function inhibitor activity, protein binding, ubiquitin protein ligase binding; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, nuclear speck, nucleus
Pathways: Adaptive Immune System, Co-inhibition by PD-1, Hedgehog 'on' state, Hedgehog signaling pathway - Mus musculus (mouse), Immune System, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SPOP-mediated proteasomal degradation of PD-L1(CD274), Signal Transduction, Signaling by Hedgehog
UniProt: Q6ZWS8
Entrez ID: 20747
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sox6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Sox6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sox6 (SRY (sex determining region Y)-box 6)
Type: protein-coding
Summary: This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: astrocyte differentiation, brain development, cardiac muscle cell differentiation, cartilage condensation, cartilage development, cell differentiation, cell fate commitment, cell morphogenesis, cellular response to transforming growth factor beta stimulus, central nervous system development, chondrocyte differentiation, erythrocyte development, erythrocyte differentiation, gene expression, hemopoiesis, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of cardiac muscle cell differentiation, negative regulation of transcription by RNA polymerase II, oligodendrocyte cell fate specification, oligodendrocyte differentiation, positive regulation of DNA-templated transcription, positive regulation of cartilage development, positive regulation of cell differentiation, positive regulation of chondrocyte differentiation, positive regulation of mesenchymal stem cell differentiation, positive regulation of transcription by RNA polymerase II, post-embryonic development, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II, spinal cord oligodendrocyte cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, protein binding, protein homodimerization activity, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: cytoplasm, nucleoplasm, nucleus, transcription regulator complex
Pathways: Deactivation of the beta-catenin transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: P40645
Entrez ID: 20679
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nt5c3b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 1
|
difficult
|
Does knockout of Nt5c3b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nt5c3b (5'-nucleotidase, cytosolic IIIB)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 5'-nucleotidase activity, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding; CC: cytoplasm
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Purine metabolism - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), mRNA decay by 3' to 5' exoribonuclease
UniProt: Q3UFY7
Entrez ID: 68106
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Stk11
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Stk11 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Stk11 (serine/threonine kinase 11)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: DNA damage response, G1 to G0 transition, Golgi localization, T cell receptor signaling pathway, anoikis, apoptotic process, autophagy, axonogenesis, cell differentiation, cellular response to UV-B, dendrite extension, establishment of cell polarity, glucose homeostasis, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of TORC1 signaling, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of cold-induced thermogenesis, negative regulation of epithelial cell proliferation involved in prostate gland development, positive regulation of autophagy, positive regulation of axonogenesis, positive regulation of gluconeogenesis, positive regulation of protein localization to nucleus, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of vesicle transport along microtubule, positive thymic T cell selection, protein autophosphorylation, protein dephosphorylation, protein phosphorylation, regulation of Wnt signaling pathway, regulation of cell growth, regulation of dendrite morphogenesis, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, response to ionizing radiation, response to lipid, signal transduction, spermatid development, spermatogenesis, tissue homeostasis, vasculature development; MF: ATP binding, LRR domain binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, p53 binding, protein binding, protein kinase activator activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, transferase activity; CC: Z disc, centrosome, cilium, cytoplasm, cytosol, intracellular protein-containing complex, membrane, mitochondrion, nucleoplasm, nucleus, protein-containing complex, serine/threonine protein kinase complex
Pathways: AMPK signaling pathway - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Energy dependent regulation of mTOR by LKB1-AMPK, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Longevity regulating pathway - Mus musculus (mouse), MTOR signalling, PI3K-Akt signaling pathway - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, Tight junction - Mus musculus (mouse), Transcriptional Regulation by TP53, mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q9WTK7
Entrez ID: 20869
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
H2-K1
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of H2-K1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: H2-K1 (histocompatibility 2, K1, K region)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antigen processing and presentation, antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent, antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, antigen processing and presentation of exogenous peptide antigen via MHC class I, antigen processing and presentation of peptide antigen via MHC class I, defense response to bacterium, immune response, immune system process, inner ear development, negative regulation of neuron projection development, positive regulation of T cell mediated cytotoxicity; MF: 14-3-3 protein binding, CD8 receptor binding, MHC class I protein binding, T cell receptor binding, TAP binding, TAP complex binding, TAP1 binding, TAP2 binding, beta-2-microglobulin binding, identical protein binding, natural killer cell lectin-like receptor binding, peptide antigen binding, protein binding, protein homodimerization activity, protein-folding chaperone binding, receptor ligand activity, signaling receptor binding; CC: Golgi apparatus, Golgi medial cisterna, Golgi membrane, MHC class I peptide loading complex, MHC class I protein complex, MHC class Ib protein complex, cell surface, cis-Golgi network membrane, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum exit site, external side of plasma membrane, extracellular space, lumenal side of endoplasmic reticulum membrane, lysosomal membrane, membrane, phagocytic vesicle membrane, plasma membrane
Pathways: Adaptive Immune System, Allograft rejection - Mus musculus (mouse), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Autoimmune thyroid disease - Mus musculus (mouse), Cell adhesion molecules - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, DAP12 interactions, ER-Phagosome pathway, Endocytosis - Mus musculus (mouse), Endosomal/Vacuolar pathway, Epstein-Barr virus infection - Mus musculus (mouse), Graft-versus-host disease - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Neutrophil degranulation, Phagosome - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse)
UniProt: P01901
Entrez ID: 14972
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Keap1
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Keap1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Keap1 (kelch-like ECH-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to carbohydrate stimulus, cellular response to interleukin-4, cellular response to oxidative stress, in utero embryonic development, negative regulation of gene expression, negative regulation of response to oxidative stress, negative regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein ubiquitination, regulation of DNA-templated transcription, regulation of autophagy, regulation of epidermal cell differentiation, response to oxidative stress, ubiquitin-dependent protein catabolic process; MF: RNA polymerase II-specific DNA-binding transcription factor binding, disordered domain specific binding, identical protein binding, protein binding, transcription regulator inhibitor activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, actin filament, adherens junction, centriolar satellite, cytoplasm, cytosol, endoplasmic reticulum, focal adhesion, inclusion body, midbody, nucleoplasm, nucleus, protein-containing complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Deubiquitination, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Immune System, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9Z2X8
Entrez ID: 50868
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pcna
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Pcna in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Pcna (proliferating cell nuclear antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, base-excision repair, gap-filling, cellular response to UV, cellular response to hydrogen peroxide, cellular response to xenobiotic stimulus, chromatin organization, epithelial cell differentiation, estrous cycle, heart development, leading strand elongation, liver regeneration, mismatch repair, mitotic telomere maintenance via semi-conservative replication, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA replication, positive regulation of deoxyribonuclease activity, regulation of DNA replication, replication fork processing, response to L-glutamate, response to cadmium ion, response to dexamethasone, response to estradiol, response to lipid, response to oxidative stress, translesion synthesis; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, MutLalpha complex binding, chromatin binding, damaged DNA binding, dinucleotide insertion or deletion binding, enzyme binding, histone acetyltransferase binding, identical protein binding, nuclear estrogen receptor binding, protein binding, protein-containing complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, receptor tyrosine kinase binding; CC: PCNA complex, PCNA-p21 complex, centrosome, chromatin, cyclin-dependent protein kinase holoenzyme complex, male germ cell nucleus, nuclear body, nuclear lamina, nuclear replication fork, nucleoplasm, nucleus, replication fork
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatitis B - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Metabolism of proteins, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Post-translational protein modification, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Protein ubiquitination, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Synthesis of DNA, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Tight junction - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P17918
Entrez ID: 18538
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Top1
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Top1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Top1 (topoisomerase (DNA) I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA topological change, animal organ regeneration, cellular response to luteinizing hormone stimulus, chromatin remodeling, chromosome segregation, circadian regulation of gene expression, circadian rhythm, embryonic cleavage, rRNA transcription, response to cAMP, response to gamma radiation, response to temperature stimulus, response to xenobiotic stimulus, rhythmic process; MF: ATP binding, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, isomerase activity, protein domain specific binding, protein serine/threonine kinase activity, protein-containing complex binding, single-stranded DNA binding, supercoiled DNA binding; CC: P-body, chromosome, cytoplasm, dense fibrillar component, fibrillar center, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, perikaryon, protein-DNA complex
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: Q04750
Entrez ID: 21969
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Setdb1
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Setdb1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Setdb1 (SET domain, bifurcated 1)
Type: protein-coding
Summary: Enables DNA binding activity; histone H3K9 methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation-dependent constitutive heterochromatin formation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and transposable element silencing by heterochromatin formation. Acts upstream of or within bone development; inner cell mass cell proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including 1-cell stage embryo; central nervous system; heart; long bone; and oocyte. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, bone development, chromatin organization, heterochromatin organization, inner cell mass cell proliferation, methylation, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of transcription by RNA polymerase II, transposable element silencing by heterochromatin formation; MF: DNA binding, chromatin binding, histone H3K9 dimethyltransferase activity, histone H3K9 methyltransferase activity, histone H3K9 monomethyltransferase activity, histone H3K9 trimethyltransferase activity, histone H3K9me2 methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, promoter-specific chromatin binding, protein binding, transferase activity, zinc ion binding; CC: chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Lysine degradation - Mus musculus (mouse), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: G5E8N3, D3YYC3
Entrez ID: 84505
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Map3k1
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Map3k1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Map3k1 (mitogen-activated protein kinase kinase kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, MAPK cascade, apoptotic mitochondrial changes, camera-type eye development, cell surface receptor signaling pathway, epithelial cell morphogenesis, eyelid development in camera-type eye, morphogenesis of an epithelial sheet, negative regulation of actin filament bundle assembly, positive regulation of DNA-templated transcription, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of actin filament polymerization, positive regulation of apoptotic process, positive regulation of canonical Wnt signaling pathway, positive regulation of transcription by RNA polymerase II, positive regulation of viral transcription, protein polyubiquitination, regulation of actin filament organization, regulation of cell migration, transforming growth factor beta receptor signaling pathway, ubiquitin-dependent protein catabolic process, wound healing; MF: ATP binding, JUN kinase binding, JUN kinase kinase kinase activity, MAP kinase kinase activity, MAP kinase kinase kinase activity, cytoskeletal protein binding, kinase activity, metal ion binding, mitogen-activated protein kinase binding, mitogen-activated protein kinase kinase binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, protein-containing complex binding, sphingolipid binding, transferase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, filamentous actin, tight junction
Pathways: GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: D3YVX9, F8VQ72
Entrez ID: 26401
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Egfr
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Egfr in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Egfr (epidermal growth factor receptor)
Type: protein-coding
Summary: Enables epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in ERBB2-EGFR signaling pathway; cellular response to amino acid stimulus; and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including eyelid development in camera-type eye; protein modification process; and regulation of epidermal growth factor receptor signaling pathway. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and sensory organ. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung cancer (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: ERBB2-EGFR signaling pathway, astrocyte activation, cell morphogenesis, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, cell-cell adhesion, cellular response to amino acid stimulus, cellular response to epidermal growth factor stimulus, cellular response to estradiol stimulus, cellular response to growth factor stimulus, cerebral cortex cell migration, digestive tract morphogenesis, embryonic placenta development, epidermal growth factor receptor signaling pathway, epidermis development, eyelid development in camera-type eye, gene expression, hair follicle development, intracellular signal transduction, learning or memory, liver regeneration, morphogenesis of an epithelial fold, negative regulation of apoptotic process, negative regulation of cardiocyte differentiation, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of mitotic cell cycle, negative regulation of protein catabolic process, neuron differentiation, neuron projection morphogenesis, ovulation cycle, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of DNA repair, positive regulation of DNA replication, positive regulation of ERK1 and ERK2 cascade, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of MAPK cascade, positive regulation of bone resorption, positive regulation of canonical Wnt signaling pathway, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of epithelial cell proliferation, positive regulation of fibroblast proliferation, positive regulation of glial cell proliferation, positive regulation of miRNA transcription, positive regulation of mucus secretion, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phosphorylation, positive regulation of prolactin secretion, positive regulation of protein kinase C signaling, positive regulation of protein localization to early endosome, positive regulation of protein localization to plasma membrane, positive regulation of protein phosphorylation, positive regulation of smooth muscle cell proliferation, positive regulation of superoxide anion generation, positive regulation of synaptic transmission, glutamatergic, positive regulation of transcription by RNA polymerase II, positive regulation of vasoconstriction, protein ubiquitination, regulation of cell population proliferation, response to UV-A, response to calcium ion, salivary gland morphogenesis, signal transduction, telencephalon development, translation, ubiquitin-dependent endocytosis, ubiquitin-dependent protein catabolic process, vasodilation, xenobiotic transport; MF: ATP binding, actin filament binding, calmodulin binding, chromatin binding, enzyme binding, epidermal growth factor binding, epidermal growth factor receptor activity, identical protein binding, integrin binding, kinase activity, kinase binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein phosphatase binding, protein tyrosine kinase activator activity, protein tyrosine kinase activity, protein-containing complex binding, signaling receptor binding, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane signaling receptor activity, ubiquitin protein ligase binding; CC: Golgi apparatus, Golgi membrane, apical plasma membrane, basal plasma membrane, basolateral plasma membrane, cell junction, cell surface, ciliary basal body, cilium, cytoplasm, cytosol, early endosome membrane, endocytic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, glutamatergic synapse, intracellular vesicle, membrane, membrane raft, multivesicular body, internal vesicle lumen, nuclear membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, protein-containing complex, receptor complex, ruffle membrane, synaptic membrane
Pathways: Adherens junction - Mus musculus (mouse), Axon guidance, Bladder cancer - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cargo recognition for clathrin-mediated endocytosis, Central carbon metabolism in cancer - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Clathrin-mediated endocytosis, Colorectal cancer - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cushing syndrome - Mus musculus (mouse), Developmental Biology, Downregulation of ERBB2 signaling, EGFR Transactivation by Gastrin, EGFR downregulation, EGFR interacts with phospholipase C-gamma, ERBB2 Activates PTK6 Signaling, ERBB2 Regulates Cell Motility, ESR-mediated signaling, Endocytosis - Mus musculus (mouse), Endometrial cancer - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GAB1 signalosome, GPCR downstream signalling, GRB2 events in EGFR signaling, Gap junction - Mus musculus (mouse), Gastric cancer - Mus musculus (mouse), Gastrin-CREB signalling pathway via PKC and MAPK, Glioma - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), L1CAM interactions, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Membrane Trafficking, MicroRNAs in cancer - Mus musculus (mouse), NOTCH3 Activation and Transmission of Signal to the Nucleus, Negative regulation of the PI3K/AKT network, Nervous system development, Non-small cell lung cancer - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K events in ERBB2 signaling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PTK6 promotes HIF1A stabilization, Pancreatic cancer - Mus musculus (mouse), Parathyroid hormone synthesis, secretion and action - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), SHC1 events in EGFR signaling, SHC1 events in ERBB2 signaling, Signal Transduction, Signal transduction by L1, Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by GPCR, Signaling by NOTCH, Signaling by NOTCH3, Signaling by Non-Receptor Tyrosine Kinases, Signaling by Nuclear Receptors, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Vesicle-mediated transport
UniProt: Q01279
Entrez ID: 13649
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tsc2
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Tsc2 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Tsc2 (TSC complex subunit 2)
Type: protein-coding
Summary: Enables 14-3-3 protein binding activity and GTPase activator activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several processes, including intracellular protein transport; negative regulation of lymphocyte proliferation; and regulation of signal transduction. Located in cytoplasm. Part of TSC1-TSC2 complex. Is active in lysosomal membrane and synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: D-glucose import, TORC1 signaling, anoikis, cell projection organization, cellular response to insulin stimulus, cellular response to nutrient levels, cellular response to starvation, connective tissue replacement, cytoplasmic translation, establishment of cell polarity, excitatory chemical synaptic transmission, heart development, inhibitory chemical synaptic transmission, intracellular protein localization, kidney development, myofibroblast differentiation, negative regulation of B cell proliferation, negative regulation of T cell proliferation, negative regulation of TOR signaling, negative regulation of TORC1 signaling, negative regulation of Wnt signaling pathway, negative regulation of axonogenesis, negative regulation of cell population proliferation, negative regulation of cell size, negative regulation of epithelial cell proliferation, negative regulation of epithelial to mesenchymal transition, negative regulation of fibroblast proliferation, negative regulation of insulin receptor signaling pathway, negative regulation of macroautophagy, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of pinocytosis, negative regulation of translational initiation, negative regulation of vascular endothelial cell proliferation, neural tube closure, positive chemotaxis, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of cell adhesion, positive regulation of dendritic spine development, positive regulation of fibroblast migration, positive regulation of insulin receptor signaling pathway, positive regulation of macroautophagy, positive regulation of neuron projection development, positive regulation of transcription by RNA polymerase II, positive regulation of translational initiation, protein import into nucleus, protein localization to cell surface, protein transport into plasma membrane raft, proximal tubule development, regulation of cell cycle, regulation of endocytosis, regulation of insulin receptor signaling pathway, regulation of macroautophagy, regulation of postsynapse organization, regulation of small GTPase mediated signal transduction, response to hypoxia, social behavior, tissue remodeling; MF: 14-3-3 protein binding, GTPase activator activity, Hsp90 protein binding, phosphatase binding, protein binding, protein homodimerization activity, protein-containing complex binding, small GTPase binding; CC: Golgi apparatus, TSC1-TSC2 complex, caveola, cell projection, cytoplasm, cytosol, dendrite, glutamatergic synapse, growth cone, lysosomal membrane, lysosome, membrane, neuronal cell body, nucleus, perinuclear region of cytoplasm, postsynaptic density, synapse
Pathways: AMPK signaling pathway - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: Q3UHB2, Q7TT21, Q3TQ10, A0A2I3BRT5, Q3UGI8, A0A2I3BPP1, Q3UG88, A0A2I3BPR7, A0A2I3BRA1, A0A2I3BPE9
Entrez ID: 22084
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Setd2
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Setd2 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Setd2 (SET domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, angiogenesis, autophagosome assembly, cell differentiation, cell migration involved in vasculogenesis, chromatin organization, coronary vasculature morphogenesis, defense response to virus, embryonic cranial skeleton morphogenesis, embryonic organ development, embryonic placenta morphogenesis, endodermal cell differentiation, forebrain development, immune system process, innate immune response, mesoderm morphogenesis, methylation, microtubule cytoskeleton organization involved in mitosis, mismatch repair, morphogenesis of a branching structure, neural tube closure, nucleosome organization, peptidyl-lysine trimethylation, pericardium development, positive regulation of autophagy, positive regulation of interferon-alpha production, positive regulation of ossification, proteasomal protein catabolic process, protein K48-linked ubiquitination, regulation of DNA-templated transcription, regulation of cytokinesis, regulation of double-strand break repair via homologous recombination, regulation of gene expression, regulation of mRNA export from nucleus, regulation of protein localization to chromatin, response to type I interferon, stem cell development, stem cell differentiation, transcription elongation by RNA polymerase II, vasculogenesis; MF: alpha-tubulin binding, histone H3K36 methyltransferase activity, histone H3K36 trimethyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity; CC: chromosome, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Lysine degradation - Mus musculus (mouse), PKMTs methylate histone lysines
UniProt: E9Q5F9
Entrez ID: 235626
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tap1
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Tap1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Tap1 (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP))
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: adaptive immune response, antigen processing and presentation of endogenous peptide antigen via MHC class I, cytosol to endoplasmic reticulum transport, defense response, immune system process, peptide antigen assembly with MHC class I protein complex, peptide transport, protection from natural killer cell mediated cytotoxicity, protein transport, transmembrane transport; MF: ABC-type peptide antigen transporter activity, ABC-type transporter activity, ADP binding, ATP binding, ATP hydrolysis activity, MHC class I protein binding, MHC class Ib protein binding, TAP1 binding, TAP2 binding, metal ion binding, nucleotide binding, peptide antigen binding, peptide transmembrane transporter activity, protein homodimerization activity, protein-containing complex binding, tapasin binding; CC: MHC class I peptide loading complex, TAP complex, centriolar satellite, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, organelle membrane, phagocytic vesicle membrane
Pathways: ABC transporters - Mus musculus (mouse), Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, ER-Phagosome pathway, Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Phagosome - Mus musculus (mouse), Primary immunodeficiency - Mus musculus (mouse)
UniProt: P21958
Entrez ID: 21354
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Casp8
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Casp8 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Casp8 (caspase 8)
Type: protein-coding
Summary: This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: TRAIL-activated apoptotic signaling pathway, angiogenesis, animal organ development, apoptotic process, apoptotic signaling pathway, cardiac muscle tissue development, cell differentiation, chordate embryonic development, execution phase of apoptosis, extrinsic apoptotic signaling pathway, extrinsic apoptotic signaling pathway via death domain receptors, heart development, hepatocyte apoptotic process, macrophage differentiation, negative regulation of canonical NF-kappaB signal transduction, negative regulation of necroptotic process, neural tube formation, positive regulation of apoptotic process, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of execution phase of apoptosis, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of interleukin-1 beta production, positive regulation of macrophage differentiation, positive regulation of neuron apoptotic process, positive regulation of proteolysis, positive regulation of pyroptotic inflammatory response, positive regulation of signal transduction, protein maturation, protein processing, proteolysis, proteolysis involved in protein catabolic process, pyroptotic inflammatory response, regulation of apoptotic process, regulation of apoptotic signaling pathway, regulation of cytokine production, regulation of immune system process, regulation of innate immune response, regulation of thymocyte apoptotic process, response to ethanol, response to tumor necrosis factor, self proteolysis; MF: cysteine-type endopeptidase activator activity involved in apoptotic process, cysteine-type endopeptidase activity, cysteine-type peptidase activity, death effector domain binding, death receptor binding, endopeptidase activity, hydrolase activity, identical protein binding, peptidase activity, protein binding, protein-containing complex binding, scaffold protein binding, tumor necrosis factor receptor binding, ubiquitin protein ligase binding; CC: CD95 death-inducing signaling complex, Noc1p-Noc2p complex, cell body, cytoplasm, cytosol, death-inducing signaling complex, lamellipodium, mitochondrion, nucleus, plasma membrane, protein-containing complex, ripoptosome
Pathways: Activation, myristolyation of BID and translocation to mitochondria, Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apoptosis, Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), Apoptotic cleavage of cellular proteins, Apoptotic execution phase, C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CASP8 activity is inhibited, CLEC7A (Dectin-1) signaling, CLEC7A/inflammasome pathway, Caspase activation via Death Receptors in the presence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Caspase-mediated cleavage of cytoskeletal proteins, Chagas disease - Mus musculus (mouse), Cytokine Signaling in Immune system, Death Receptor Signaling, Dimerization of procaspase-8, Epstein-Barr virus infection - Mus musculus (mouse), FasL/ CD95L signaling, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Influenza A - Mus musculus (mouse), Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intrinsic Pathway for Apoptosis, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD-like receptor signaling pathway - Mus musculus (mouse), NOD1/2 Signaling Pathway, Necroptosis - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Programmed Cell Death, RIG-I-like receptor signaling pathway - Mus musculus (mouse), RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation by c-FLIP, Regulation of NF-kappa B signaling, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TNF signaling, TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAIL signaling, TRIF (TICAM1)-mediated TLR4 signaling , TRIF-mediated programmed cell death, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: O89110
Entrez ID: 12370
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps6
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Rps6 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Rps6 (ribosomal protein S6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, T cell differentiation in thymus, T cell proliferation involved in immune response, TOR signaling, activation-induced cell death of T cells, cellular response to ethanol, cytoplasmic translation, erythrocyte development, gastrulation, glucose homeostasis, mammalian oogenesis stage, mitotic cell cycle, negative regulation of apoptotic process, negative regulation of bicellular tight junction assembly, placenta development, positive regulation of apoptotic process, positive regulation of cell population proliferation, rRNA processing, response to insulin, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis, translation; MF: mRNA binding, protein binding, protein kinase binding, structural constituent of ribosome; CC: GABA-ergic synapse, cell body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, dendrite, endoplasmic reticulum, nucleolus, nucleus, perinuclear region of cytoplasm, presynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Apelin signaling pathway - Mus musculus (mouse), Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, HIF-1 signaling pathway - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), L13a-mediated translational silencing of Ceruloplasmin expression, MTOR signalling, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, PI3K-Akt signaling pathway - Mus musculus (mouse), Post-translational protein modification, Protein hydroxylation, Proteoglycans in cancer - Mus musculus (mouse), Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Signal Transduction, Thermogenesis - Mus musculus (mouse), Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62754
Entrez ID: 20104
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Men1
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Men1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Men1 (multiple endocrine neoplasia 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, MAPK cascade, T-helper 2 cell differentiation, chromatin organization, chromatin remodeling, embryonic skeletal system morphogenesis, hemopoiesis, leukocyte homeostasis, maternal process involved in female pregnancy, negative regulation of DNA-templated transcription, negative regulation of JNK cascade, negative regulation of cell cycle, negative regulation of cell cycle G1/S phase transition, negative regulation of cell population proliferation, negative regulation of cell-substrate adhesion, negative regulation of epithelial cell proliferation, negative regulation of fibroblast proliferation, negative regulation of organ growth, negative regulation of osteoblast differentiation, negative regulation of stem cell proliferation, negative regulation of transcription by RNA polymerase II, negative regulation of type B pancreatic cell proliferation, ossification, osteoblast development, osteoblast fate commitment, positive regulation of DNA-templated transcription, positive regulation of cell division, positive regulation of fibroblast apoptotic process, positive regulation of gene expression, positive regulation of osteoblast differentiation, positive regulation of stem cell differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, regulation of G1/S transition of mitotic cell cycle, regulation of activin receptor signaling pathway, regulation of gene expression, regulation of transcription by RNA polymerase II, regulation of type B pancreatic cell proliferation, response to UV, response to gamma radiation, response to transforming growth factor beta, roof of mouth development, transcription initiation-coupled chromatin remodeling, type B pancreatic cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, R-SMAD binding, Y-form DNA binding, chromatin binding, double-stranded DNA binding, four-way junction DNA binding, phosphoprotein binding, protein binding, protein-macromolecule adaptor activity, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: MLL1 complex, MLL1/2 complex, chromatin, chromosome, telomeric region, cleavage furrow, cytoplasm, cytosol, histone methyltransferase complex, nuclear matrix, nucleoplasm, nucleus, protein-containing complex, transcription repressor complex
Pathways: Cushing syndrome - Mus musculus (mouse), Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Formation of the beta-catenin:TCF transactivating complex, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, RHO GTPase Effectors, RHO GTPases activate IQGAPs, RNA Polymerase II Transcription, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, TCF dependent signaling in response to WNT, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: O88559
Entrez ID: 17283
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cd47
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Cd47 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Cd47 (CD47 antigen (Rh-related antigen, integrin-associated signal transducer))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP export, angiogenesis, apoptotic process, cell adhesion, cell migration, cell-cell adhesion, cellular response to interleukin-1, cellular response to interleukin-12, cellular response to type II interferon, inflammatory response, monocyte aggregation, negative regulation of phagocytosis, opsonization, positive regulation of T cell activation, positive regulation of activation-induced cell death of T cells, positive regulation of cell population proliferation, positive regulation of cell-cell adhesion, positive regulation of immune system process, positive regulation of inflammatory response, positive regulation of monocyte extravasation, positive regulation of phagocytosis, positive regulation of stress fiber assembly, regulation of Fc receptor mediated stimulatory signaling pathway, regulation of interleukin-10 production, regulation of interleukin-12 production, regulation of interleukin-6 production, regulation of nitric oxide biosynthetic process, regulation of synapse pruning, regulation of tumor necrosis factor production, regulation of type II interferon production, response to bacterium; MF: cell-cell adhesion mediator activity, fibrinogen binding, protein binding, protein binding involved in heterotypic cell-cell adhesion, thrombospondin receptor activity; CC: cell surface, extracellular exosome, glutamatergic synapse, membrane, plasma membrane, presynapse
Pathways: Cell surface interactions at the vascular wall, Cell-Cell communication, ECM-receptor interaction - Mus musculus (mouse), Extracellular matrix organization, Hemostasis, Immune System, Innate Immune System, Integrin cell surface interactions, Neutrophil degranulation, Signal regulatory protein family interactions
UniProt: Q61735
Entrez ID: 16423
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Asxl1
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Asxl1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Asxl1 (ASXL transcriptional regulator 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ morphogenesis, bone development, bone marrow development, cell morphogenesis, chromatin organization, heart morphogenesis, hematopoietic or lymphoid organ development, hemopoiesis, homeostasis of number of cells, lung saccule development, negative regulation of fat cell differentiation, negative regulation of lipid storage, negative regulation of peroxisome proliferator activated receptor signaling pathway, podocyte development, positive regulation of retinoic acid receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of kidney size, response to retinoic acid, thymus development; MF: DNA binding, chromatin binding, metal ion binding, nuclear retinoic acid receptor binding, peroxisome proliferator activated receptor binding, protein binding, transcription coactivator activity, zinc ion binding; CC: PR-DUB complex, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, UCH proteinases
UniProt: P59598
Entrez ID: 228790
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sufu
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Sufu in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Sufu (SUFU negative regulator of hedgehog signaling)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, coronary vasculature development, determination of left/right symmetry, dorsal/ventral neural tube patterning, heart looping, maintenance of protein localization in organelle, negative regulation of smoothened signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of ubiquitin-dependent protein catabolic process, neural tube closure, positive regulation of cellular response to drug, regulation of DNA-templated transcription, signal transduction, skin development, smoothened signaling pathway, smoothened signaling pathway involved in spinal cord motor neuron cell fate specification, smoothened signaling pathway involved in ventral spinal cord interneuron specification, spermatid development, spinal cord dorsal/ventral patterning, spinal cord motor neuron cell fate specification, ventral spinal cord interneuron specification, ventricular septum development; MF: beta-catenin binding, protein binding, protein kinase binding, protein sequestering activity; CC: GLI-SUFU complex, cilium, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Basal cell carcinoma - Mus musculus (mouse), Degradation of GLI1 by the proteasome, GLI3 is processed to GLI3R by the proteasome, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Signal Transduction, Signaling by Hedgehog
UniProt: Q9Z0P7
Entrez ID: 24069
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
B2m
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of B2m in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: B2m (beta-2 microglobulin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell differentiation in thymus, amyloid fibril formation, antibacterial humoral response, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent, antigen processing and presentation of peptide antigen via MHC class I, antimicrobial humoral immune response mediated by antimicrobial peptide, cellular defense response, cellular response to iron ion, cellular response to iron(III) ion, cellular response to lipopolysaccharide, cellular response to nicotine, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, immune response, immune system process, innate immune response, intracellular iron ion homeostasis, iron ion transport, learning or memory, multicellular organismal-level iron ion homeostasis, negative regulation of epithelial cell proliferation, negative regulation of forebrain neuron differentiation, negative regulation of iron ion transport, negative regulation of neurogenesis, negative regulation of neuron projection development, negative regulation of receptor-mediated endocytosis, peptide antigen assembly with MHC class I protein complex, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of T cell cytokine production, positive regulation of T cell mediated cytotoxicity, positive regulation of cellular senescence, positive regulation of immune response, positive regulation of receptor-mediated endocytosis, protein homotetramerization, protein refolding, regulation of erythrocyte differentiation, regulation of iron ion transport, regulation of membrane depolarization, response to metal ion, response to molecule of bacterial origin, sensory perception of smell, transferrin transport; MF: MHC class II protein complex binding, identical protein binding, peptide antigen binding, protein binding, protein homodimerization activity, structural molecule activity; CC: Golgi apparatus, HFE-transferrin receptor complex, MHC class I peptide loading complex, MHC class I protein complex, MHC class II protein complex, cytosol, external side of plasma membrane, extracellular region, extracellular space, late endosome membrane, lysosomal membrane, phagocytic vesicle membrane, plasma membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Mus musculus (mouse), Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, DAP12 interactions, DAP12 signaling, ER-Phagosome pathway, Endosomal/Vacuolar pathway, Epstein-Barr virus infection - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Neutrophil degranulation
UniProt: P01887
Entrez ID: 12010
|
SCREEN_17_HITS_ONLY.tsv
|
mouse
|
knockout
|
Stat1
|
3LL Lewis lung carcinoma cells
|
increased resistance to PD1 blockade and lung carcinoma cell survival
| 1
|
difficult
|
Does knockout of Stat1 in 3LL Lewis lung carcinoma cells causally result in increased resistance to PD1 blockade and lung carcinoma cell survival?
|
Gene: Stat1 (signal transducer and activator of transcription 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, blood circulation, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, cellular response to cytokine stimulus, cellular response to interferon-beta, cellular response to lipopolysaccharide, cellular response to type II interferon, cytokine-mediated signaling pathway, defense response, defense response to virus, interleukin-27-mediated signaling pathway, interleukin-7-mediated signaling pathway, interleukin-9-mediated signaling pathway, lipopolysaccharide-mediated signaling pathway, metanephric mesenchymal cell differentiation, metanephric mesenchymal cell proliferation involved in metanephros development, negative regulation by virus of viral protein levels in host cell, negative regulation of angiogenesis, negative regulation of canonical NF-kappaB signal transduction, negative regulation of developmental process, negative regulation of endothelial cell proliferation, negative regulation of macrophage fusion, negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, negative regulation of metanephric nephron tubule epithelial cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of defense response to virus by host, positive regulation of erythrocyte differentiation, positive regulation of interferon-alpha production, positive regulation of mesenchymal cell proliferation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of smooth muscle cell proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, renal tubule development, response to bacterium, response to cAMP, response to cytokine, response to exogenous dsRNA, response to interferon-beta, response to lipopolysaccharide, response to peptide hormone, response to type I interferon, response to type II interferon, signal transduction, tumor necrosis factor-mediated signaling pathway, type I interferon-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: CCR5 chemokine receptor binding, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, enzyme binding, histone acetyltransferase binding, histone binding, identical protein binding, promoter-specific chromatin binding, protein binding, protein homodimerization activity, protein phosphatase 2A binding, sequence-specific DNA binding, transcription coactivator binding, transcription corepressor binding, tumor necrosis factor receptor binding, ubiquitin-like protein ligase binding; CC: ISGF3 complex, RNA polymerase II transcription regulator complex, axon, chromatin, cytoplasm, cytosol, dendrite, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), Inflammatory bowel disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Measles - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q8C3V4, Q99K94, Q8CFQ1, Q8C8M3, Q8C497, A0A087WSP5, A0A087WRI1, A0A087WSQ5
Entrez ID: 20846
|
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