screen_file string | organism string | perturbation string | gene string | cell string | phenotype string | hit int64 | benchmark_type string | prompt string | gene_context string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Eif3f | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Eif3f in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Eif3f (eukaryotic translation initiation factor 3, subunit F)
Type: protein-coding
Summary: Enables cysteine-type deubiquitinase activity and translation initiation factor binding activity. Contributes to translation initiation factor activity. Involved in translational initiation. Part of eukaryo... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | 2700062C07Rik | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of 2700062C07Rik in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: 2700062C07Rik (RIKEN cDNA 2700062C07 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, biological_process; CC: cellular_component, nucleus, ribonuclease MRP complex
Pathways:
UniProt: Q5XFZ0
Entrez ID: 68046 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Slc25a19 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Slc25a19 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Slc25a19 (solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: deoxynucleotide transport, thiamine diphosphate biosynthetic process, thiamine pyrophosphate transmembrane transport, thiami... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Mrpl53 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Mrpl53 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Mrpl53 (mitochondrial ribosomal protein L53)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondr... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Eif3a | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Eif3a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Eif3a (eukaryotic translation initiation factor 3, subunit A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, negative regul... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Mfn2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Mfn2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Mfn2 (mitofusin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, apoptotic process, autophagy, blastocyst formation, camera-type eye morphogenesis, intracellular distribution of mitochondria, mitochondrial calcium ion homeostasis, mitochondria... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Abce1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Abce1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Abce1 (ATP-binding cassette, sub-family E member 1)
Type: protein-coding
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cdkn2a | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Cdkn2a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cdkn2a (cyclin dependent kinase inhibitor 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid fibril formation, apoptotic process, apoptotic signaling pathway, autophagy of mitochondrion, cellular response to gamma radiation, cellular response to hydrogen pe... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cad | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Cad in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cad (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, UTP biosyntheti... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Psmd13 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Psmd13 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Psmd13 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiosis I, ubiquitin-dependent protein catabolic process; MF: endopeptidase activity, structural molecule activity; CC: cytosol, nucleus, proteasome ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cep55 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Cep55 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cep55 (centrosomal protein 55)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Located in intercellular bridge and midbody. Is expre... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Vps18 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Vps18 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Vps18 (VPS18 CORVET/HOPS core subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, endosome organization, endosome to lysosome transport, intracellular protein transport, lysosome organization, negative regulation of intracellular estrogen receptor si... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ttc14 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Ttc14 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ttc14 (tetratricopeptide repeat domain 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: nucleic acid binding, protein binding
Pathways:
UniProt: Q9CSP9
Entrez ID: 67120 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ptcd1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Ptcd1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ptcd1 (pentatricopeptide repeat domain 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, tRNA 3'-end processing, tRNA processing; MF: tRNA binding; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q8C2E4
... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Snx7 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Snx7 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Snx7 (sorting nexin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endocytic recycling, mitophagy, piecemeal microautophagy of the nucleus, positive regulation of autophagosome assembly, protein transport, reticulophagy; MF: lipid binding, phosphatidylinositol b... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Chmp3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Chmp3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Chmp3 (charged multivesicular body protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, cell division, endosome to lysosome transport, endosome transport via multivesicular body sorting pathway, late endosome to lysosome tr... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Nudc | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Nudc in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Nudc (nudC nuclear distribution protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, establishment of organelle localization, mitotic metaphase chromosome alignment, mitotic spindle organization, nuclear migration, protein folding, response to pep... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Igf1r | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Igf1r in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Igf1r (insulin-like growth factor I receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adrenal gland development, amyloid-beta clearance, animal organ morphogenesis, axonogenesis, brain development, cell surface receptor protein tyrosine kinase signaling path... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Exosc3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Exosc3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Exosc3 (exosome component 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CUT catabolic process, DNA deamination, DNA metabolic process, RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, U4 snRNA 3'-end processing, exonucleolytic t... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cenpp | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Cenpp in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cenpp (centromere protein P)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CENP-A containing chromatin assembly, biological_process, chromosome segregation; CC: chromosome, chromosome, centromeric region, inner kinetochore, nucleolus, nucleoplasm, nucleus
... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rps20 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Rps20 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rps20 (ribosomal protein S20)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Kti12 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Kti12 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Kti12 (KTI12 homolog, chromatin associated)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, molecular_function, nucleotide binding
Pathways:
UniProt: Q9D1R2
Entrez ID: 100087 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Srsf5 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Srsf5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Srsf5 (serine and arginine-rich splicing factor 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gigyf1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Gigyf1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gigyf1 (GRB10 interacting GYF protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: insulin-like growth factor receptor signaling pathway; CC: cytosol, protein-containing complex
Pathways:
UniProt: Q99MR1
Entrez ID: 57330 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rrp36 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Rrp36 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rrp36 (ribosomal RNA processing 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; CC: 90S preribosom... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Tomm70a | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Tomm70a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Tomm70a (translocase of outer mitochondrial membrane 70A)
Type: protein-coding
Summary: Predicted to enable mitochondrion targeting sequence binding activity and molecular adaptor activity. Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in several p... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Pik3c2a | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Pik3c2a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Pik3c2a (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome organization, cell migration, cellular response to starvation, endocytosis, exocytosis, lipid metabolic process, macroaut... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Sdhc | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Sdhc in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Sdhc (succinate dehydrogenase complex, subunit C, integral membrane protein)
Type: protein-coding
Summary: Predicted to enable heme binding activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Located in mitochondrion. Part of respiratory chain complex I... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Fus | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Fus in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Fus (fused in sarcoma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, amyloid fibril formation, gene expression, mRNA stabilization, membraneless organelle assembly, positive regulation of DNA-templated transcription, positive regulation of double-str... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Acly | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Acly in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Acly (ATP citrate lyase)
Type: protein-coding
Summary: Enables ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and carboxylic acid metabolic process. Located in mitochondrion. Is active in cytosol. Is expressed in several structures, including alimentary ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rapgef1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Rapgef1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rapgef1 (Rap guanine nucleotide exchange factor (GEF) 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rap protein signal transduction, Ras protein signal transduction, blood vessel development, cell-cell adhesion, cellular response to cAMP, cellular response to n... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Pnpt1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Pnpt1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Pnpt1 (polyribonucleotide nucleotidyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA catabolic process, RNA import into mitochondrion, RNA processing, cellular response to interferon-beta, cellular response to oxidative stress, liver regeneration,... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Bri3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Bri3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Bri3 (brain protein I3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: identical protein binding; CC: cytoplasm, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm
Pathways: Immune System, Innate Immune System, Neutrophil degranulation... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Nsun4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Nsun4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Nsun4 (NOL1/NOP2/Sun domain family, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial RNA catabolic process, mitochondrial RNA modification, rRNA methylation, tRNA methylation; MF: RNA methyltransferase activity, mRNA (cytidine-5-)-methyltransf... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Bcl7a | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Bcl7a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Bcl7a (B cell CLL/lymphoma 7A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin remodeling, motor behavior, negative regulation of cell differentiation, neuron projection arborization, positive regulation of cell population proliferation, positive regulatio... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gm15127 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Gm15127 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gm15127 (predicted gene 15127)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: E9Q1L3, B1AVZ5
Entrez ID: 434866 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Med13 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Med13 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Med13 (mediator complex subunit 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cholesterol homeostasis, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA po... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Mbip | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Mbip in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Mbip (MAP3K12 binding inhibitory protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of JNK cascade, positive regulation of gene expression, regulation of DNA-templated transcripti... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Sptlc1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Sptlc1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Sptlc1 (serine palmitoyltransferase, long chain base subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, regulation of fat cell apoptotic process, sphinganine biosynthet... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Tmprss4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Tmprss4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Tmprss4 (transmembrane protease, serine 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of growth rate, positive regulation of viral entry into host cell, protein processing, proteolysis, regulation of gene expression, response to wounding; MF... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Lig3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Lig3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Lig3 (ligase III, DNA, ATP-dependent)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA recombination, DNA repair, DNA replication, base-excision repair, cell division, double-strand break repair, double-strand break ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Scd3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Scd3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Scd3 (stearoyl-coenzyme A desaturase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, monounsaturated fatty acid biosynthetic process, response to fatty acid, unsaturated fatty... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Atp1b3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Atp1b3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Atp1b3 (ATPase, Na+/K+ transporting, beta 3 polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular potassium ion homeostasis, intracellular sodium ion homeostasis, membrane repolarization, metal ion transport, monoatomic ion transport, positive r... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Dhx16 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Dhx16 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Dhx16 (DEAH-box helicase 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, antiviral innate immune response, immune system process, innate immune response, mRNA processing, mRNA splicing, via spliceosome; MF: ATP binding, ATP-dependent activity, acti... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Plrg1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Plrg1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Plrg1 (pleiotropic regulator 1)
Type: protein-coding
Summary: Acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle and protein localization to nucleus. Predicted to be located in fibrillar center; nuclear membrane; and nuclear speck. Predicted to be part of DNA r... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ifna12 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Ifna12 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ifna12 (interferon alpha 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, defense response, defense response to virus, humoral immune response,... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Edc3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Edc3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Edc3 (enhancer of mRNA decapping 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: P-body assembly, deadenylation-independent decapping of nuclear-transcribed mRNA; MF: RNA binding, identical protein binding, mRNA binding; CC: P-body, cytoplasm, cytoplasmic ribonuc... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cmpk1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Cmpk1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cmpk1 (cytidine/uridine monophosphate kinase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' pyrimidine nucleobase biosynthetic process, CDP biosynthetic process, UDP biosynthetic process, dCDP biosynthetic process, dUDP biosynthetic process, nucleobase... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cdh2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Cdh2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cdh2 (cadherin 2)
Type: protein-coding
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Mrpl45 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Mrpl45 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Mrpl45 (mitochondrial ribosomal protein L45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gstcd | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Gstcd in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gstcd (glutathione S-transferase, C-terminal domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, respiratory system development, response to lipopolysaccharide; MF: molecular_function, protein binding; CC: cytoplasm
Pathwa... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Actr10 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Actr10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Actr10 (ARP10 actin-related protein 10)
Type: protein-coding
Summary: Acts upstream of or within microtubule-based movement. Part of dynactin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Prpf18 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Prpf18 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Prpf18 (pre-mRNA processing factor 18)
Type: protein-coding
Summary: Predicted to be involved in generation of catalytic spliceosome for second transesterification step and negative regulation of protein metabolic process. Predicted to be located in nuclear speck. Predicted to be part of U2-type p... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Pkm | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Pkm in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Pkm (pyruvate kinase, muscle)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical glycolysis, cellular response to insulin stimulus, chromatin remodeling, glucose metabolic process, glycolytic process, positive regulation of cytoplasmic translation, positive r... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Tbcc | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Tbcc in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Tbcc (tubulin-specific chaperone C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: post-chaperonin tubulin folding pathway, protein folding, tubulin complex assembly; MF: GTPase activity, tubulin binding; CC: cytoplasm, cytosol, endoplasmic reticulum, photoreceptor... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Usp8 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Usp8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Usp8 (ubiquitin specific peptidase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Ras protein signal transduction, cellular response to dexamethasone stimulus, cellular response to nerve growth factor stimulus, endosome organization, mitotic cytokinesis, negativ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ssbp1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Ssbp1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ssbp1 (single-stranded DNA binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, mitochondrion organization, positive regulation of mitochondrial DNA replication, protein homotetramerization; MF: DNA bindi... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Chchd3 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Chchd3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Chchd3 (coiled-coil-helix-coiled-coil-helix domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cristae formation, inner mitochondrial membrane organization, mitochondrial fusion; MF: molecular adaptor activity, phosphatase binding, protein binding;... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Tectb | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Tectb in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Tectb (tectorin beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: extracellular matrix structural constituent, protein binding; CC: cell periphery, cell surface, extracellular matrix, extracellular region, extracellular space, membrane, plasma membrane, side of ... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ccl19 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Ccl19 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ccl19 (C-C motif chemokine ligand 19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CCL19-activated CCR7 signaling pathway, T cell costimulation, antimicrobial humoral immune response mediated by antimicrobial peptide, cell maturation, cell migration, cellular res... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Sp2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Sp2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Sp2 (Sp2 transcription factor)
Type: protein-coding
Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc fin... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Dcaf13 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Dcaf13 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Dcaf13 (DDB1 and CUL4 associated factor 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: decidualization, epigenetic programming in the zygotic pronuclei, female gamete generation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gm17019 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Gm17019 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gm17019 (predicted gene 17019)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: K7N6W5
Entrez ID: 66773 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Serpine1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Serpine1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Serpine1 (serine (or cysteine) peptidase inhibitor, clade E, member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to transforming growth factor beta stimulus, cellula... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Yae1d1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Yae1d1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Yae1d1 (Yae1 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein maturation; CC: cellular_component, cytoplasm, nucleus
Pathways:
UniProt: A0A1Y7VLX4, Q9DAY6
Entrez ID: 67008 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Paqr5 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Paqr5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Paqr5 (progestin and adipoQ receptor family member V)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in oogenesis. Predicted to be located in plasma membrane. Is expressed in bladder; late tubule; urinary system; and urothelium of bladder. O... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Tmem186 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Tmem186 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Tmem186 (transmembrane protein 186)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transpor... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Dna2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Dna2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Dna2 (DNA replication helicase/nuclease 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, DNA replication, DNA replication checkpoint signaling, DNA replication, Okazaki fragment processing, DNA r... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Jun | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Jun in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Jun (jun proto-oncogene)
Type: protein-coding
Summary: Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to anisomycin and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processe... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Smu1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Smu1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Smu1 (smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, regulation of alternative mRNA splicing, via spliceosome; CC: U2-type precatalytic spliceo... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cherp | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Cherp in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cherp (calcium homeostasis endoplasmic reticulum protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, intracellular calcium ion homeostasis, negative regulation of cell population proliferation, positive regulation of calcineurin-NFAT signaling c... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Gtpbp4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Gtpbp4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Gtpbp4 (GTP binding protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of DNA replication, negative regulation of G2/M transition of mitotic cell cy... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Abcf2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Abcf2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Abcf2 (ATP-binding cassette, sub-family F member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, nucleotide binding, protein binding
Pathways:
UniProt: Q99LE6
Entrez ID: 27407 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Sptlc2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Sptlc2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Sptlc2 (serine palmitoyltransferase, long chain base subunit 2)
Type: protein-coding
Summary: This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis.... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Irf9 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Irf9 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Irf9 (interferon regulatory factor 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to protozoan, dendritic cell differentiation, immune system process, lymphocyte activation involved in immune response, lymphocyte differentiation, myeloid cell di... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Sdhd | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Sdhd in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Sdhd (succinate dehydrogenase complex, subunit D, integral membrane protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to hypoxia, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthes... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ten1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Ten1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ten1 (TEN1 telomerase capping complex subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of telomere maintenance via telomerase; MF: DNA binding, single-stranded DNA binding, telomerase inhibitor activity, telomeric DNA binding; CC: CST com... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Tprkb | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Tprkb in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Tprkb (Tp53rk binding protein)
Type: protein-coding
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cyt... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Sirt6 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Sirt6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Sirt6 (sirtuin 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, Ras protein signal transduction, base-excision repair, cardiac muscle cell differentiation, cellular response to angiotensin... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Med4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Med4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Med4 (mediator complex subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive reg... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ipo11 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Ipo11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ipo11 (importin 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport, nucleocytoplasmic transport, protein import into nucleus, protein transport, ribosomal protein import into nucleus; MF: nuclear import signal receptor activity, prot... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Mrpl19 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Mrpl19 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Mrpl19 (mitochondrial ribosomal protein L19)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial riboso... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rabggta | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Rabggta in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rabggta (Rab geranylgeranyl transferase, a subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: Rab geranylgeranyltransferase activity, prenyltransferase activity, protein geranylgeranyltransferase activity, protein prenyltransferase activity, small GTPase bindi... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rpl7l1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Rpl7l1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rpl7l1 (ribosomal protein L7-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: RNA binding, structural constituent of ribosome; CC: cytosol, cyt... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Coq4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Coq4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Coq4 (coenzyme Q4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ubiquinone biosynthetic process; MF: 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity, carboxy-lyase activity, lyase activity, metal ion binding, molecular_function; CC: extrinsic comp... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Camk1d | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Camk1d in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Camk1d (calcium/calmodulin-dependent protein kinase ID)
Type: protein-coding
Summary: Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Involved in positive regulation of neuron projection development and positive regulation of neutrophil che... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Ints5 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Ints5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Ints5 (integrator complex subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, snRNA 3'-end processing, snRNA processing; CC: INTAC complex, cytoplasm, cytosol, integrator complex, membrane, nuclear memb... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Lsm12 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Lsm12 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Lsm12 (LSM12 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, molecular_function; CC: cellular_component, cytoplasm
Pathways:
UniProt: Q9D0R8
Entrez ID: 268490 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Dctn5 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Dctn5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Dctn5 (dynactin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, coronary vasculature development, ventricular septum development; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, dynactin complex, kinetochore... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rpa2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Rpa2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rpa2 (replication protein A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA replication, base-excision repair, double-strand break repair via homologous recombination, mismatch repair, mitotic G1 DNA damage c... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Pbrm1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Pbrm1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Pbrm1 (polybromo 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst formation, blood vessel remodeling, cardiac vascular smooth muscle cell development, chromatin organization, chromatin remodeling, epicardium-derived cardiac endothelial cell differentiat... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Dhx38 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Dhx38 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Dhx38 (DEAH-box helicase 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: 3'-5' RNA helicase activity, ATP binding, ATP-dependent activity, acting on RNA, RNA binding, RNA helicase activity, helic... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Riok1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Riok1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Riok1 (RIO kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the RIO family of atypical serine protein kinases. A similar protein in humans is a component of the protein arginine methyltransferase 5 complex that specifically recruits the RNA-binding protein nucleolin as a methy... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Rprd1b | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Rprd1b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Rprd1b (regulation of nuclear pre-mRNA domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, mRNA 3'-end processing, positive regulation of cell population proliferation, positive regulation of transcription by R... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Cdk4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Cdk4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Cdk4 (cyclin dependent kinase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to p... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Vmn2r42 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Vmn2r42 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Vmn2r42 (vomeronasal 2, receptor 42)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: D3YZ9... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Kdm2a | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Kdm2a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Kdm2a (lysine (K)-specific demethylase 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, circadian regulation of gene expression, double-strand break repair via nonhomologous end joining, embryonic organ morphogenesis,... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Krtap5-4 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Krtap5-4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Krtap5-4 (keratin associated protein 5-4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q62220
Entrez ID: 50775 |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Mybl2 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Mybl2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Mybl2 (myeloblastosis oncogene-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, mitotic cell cycle, mitotic spindle assembly, positive regulation of neuron apoptotic process, positive regulation of transcriptio... |
SCREEN_18_HITS_ONLY.tsv | mouse | knockout | Lonp1 | NG2-3112 mouse glioblastoma cells | increased sensitivity to gliocidin and subsequently glioblastoma cell death | 0 | difficult | Does knockout of Lonp1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death? | Gene: Lonp1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: Enables several functions, including ATP hydrolysis activity; ATP-dependent peptidase activity; and DNA binding activity. Acts upstream of or within negative regulation of insulin receptor signaling pathway; proteolysis; and regu... |
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