uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q40.1928 | Q40 | Are there any specific alleles within the gene RP1-90J20.8 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene RP1-90J20.8 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP1-90J20.8' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.614 | Q40 | Are there any specific alleles within the gene FAM234B associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cortex samples tested, there are no alleles within the gene FAM234B that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM234B' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.372 | Q40 | Are there any specific alleles within the gene RP11-60L3.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-60L3.1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-60L3.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1756 | Q40 | Are there any specific alleles within the gene FAM115D associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene FAM115D that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs2949770
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.24e-06; b: 2.2755e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM115D' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496074', 'Gene': 'FAM115D', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2949770', 'A1': 'C', 'A2': 'A', 'Freq': 0.345603, 'p_SMR_multi': 1.235843e-06, 'Disease': 'AD', 'b_SMR': 0.0227548, 'p_HEIDI': 0.0009931984}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1669 | Q40 | Are there any specific alleles within the gene RESP18 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Basal Ganglia, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested, there are no alleles within the... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RESP18' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.533 | Q40 | Are there any specific alleles within the gene KRT17P1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Prefrontal Cortex, Whole Blood and Whole Brain samples tested, there are no alleles within the gene KRT17P1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'KRT17P1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1821 | Q40 | Are there any specific alleles within the gene TSPAN15 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested, there are no alleles within the gene TSPAN15 that are signifi... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TSPAN15' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1442 | Q40 | Are there any specific alleles within the gene KRTAP10-7 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene KRTAP10-7 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'KRTAP10-7' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.302 | Q40 | Are there any specific alleles within the gene MOB3C associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Liver, Whole Blood and Whole Brain samples tested, there are no alleles within the gene MOB3C that are significantly associated with an increased susceptibility to developing Progressive supranuclear p... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MOB3C' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1016 | Q40 | Are there any specific alleles within the gene GBP1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene GBP1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GBP1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1417 | Q40 | Are there any specific alleles within the gene FAM117B associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene FAM117B that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM117B' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1567 | Q40 | Are there any specific alleles within the gene PAQR4 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene PAQR4 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PAQR4' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1311 | Q40 | Are there any specific alleles within the gene MS4A4A associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 4 alleles within the gene MS4A4A that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs1562990
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.70e-19; b: 3.0438e-01
• rs1947360
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.96e-10; b: 2.5460e... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MS4A4A' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498263', 'Gene': 'MS4A4A', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs1562990', 'A1': 'C', 'A2': 'A', 'Freq': 0.400818, 'p_SMR_multi': 4.704043999999999e-19, 'Disease': 'AD', 'b_SMR': 0.304375, 'p_HEIDI': 0.01116266}, {'UUID': 'NDD_SMR_genes_all_update_text_608697', 'Gene': 'MS... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.862 | Q40 | Are there any specific alleles within the gene BRICD5 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Caudate Basal Ganglia, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene BRICD5 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'BRICD5' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.591 | Q40 | Are there any specific alleles within the gene C8orf88 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene C8orf88 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C8orf88' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.485 | Q40 | Are there any specific alleles within the gene RABEP1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene RABEP1 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs1065483
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.90e-09; b: 2.6696e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RABEP1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501933', 'Gene': 'RABEP1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs1065483', 'A1': 'A', 'A2': 'G', 'Freq': 0.456033, 'p_SMR_multi': 8.895786e-09, 'Disease': 'AD', 'b_SMR': 0.0266958, 'p_HEIDI': 0.01261482}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1473 | Q40 | Are there any specific alleles within the gene TNFAIP8L2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene TNFAIP8L2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TNFAIP8L2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1784 | Q40 | Are there any specific alleles within the gene DSC2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene DSC2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DSC2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.644 | Q40 | Are there any specific alleles within the gene ANXA8L1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene ANXA8L1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ANXA8L1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.357 | Q40 | Are there any specific alleles within the gene PLAAT3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum and Cortex samples tested, there are no alleles within the gene PLAAT3 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PLAAT3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1128 | Q40 | Are there any specific alleles within the gene PSMD12 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Skeletal Muscle and Whole Blood samples tested, there are no alleles within the gene PSMD12 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PSMD12' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.439 | Q40 | Are there any specific alleles within the gene AC015971.2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Skeletal Muscle samples tested, there are no alleles within the gene AC015971.2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC015971.2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1121 | Q40 | Are there any specific alleles within the gene DGKQ associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 10 alleles within the gene DGKQ that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs6814642
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.42e-09; b: 2.5936e-01
• rs4690163
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: ... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DGKQ' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1236185', 'Gene': 'DGKQ', 'Omic_tissue': 'Prefrontal Cortex', 'topSNP': 'rs6814642', 'A1': 'G', 'A2': 'A', 'Freq': 0.643149, 'p_SMR_multi': 1.423406e-09, 'Disease': 'PD', 'b_SMR': 0.259356, 'p_HEIDI': 1.355011e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1430184', 'Gene': 'DGKQ... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1103 | Q40 | Are there any specific alleles within the gene SLC52A2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Putamen Basal Ganglia samples tested, there are no alleles within the gene SLC52A2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC52A2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1348 | Q40 | Are there any specific alleles within the gene EGFR associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene EGFR that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs74504435
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 7.01e-07; b: 2.3180e-01
• rs77126132
• Cortex: Adjusted SMR multi-SNP P-value: 9.98e-07; b: 1.5402... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'EGFR' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1198690', 'Gene': 'EGFR', 'Omic_tissue': 'Prefrontal Cortex', 'topSNP': 'rs74504435', 'A1': 'G', 'A2': 'A', 'Freq': 0.119632, 'p_SMR_multi': 7.014161e-07, 'Disease': 'AD', 'b_SMR': 0.231802, 'p_HEIDI': 0.2365376}, {'UUID': 'NDD_SMR_genes_all_update_text_1105868', 'Gene': 'EGFR',... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.597 | Q40 | Are there any specific alleles within the gene AC073842.19 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene AC073842.19 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs11771139
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.47e-09; b: 1.1076e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC073842.19' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_585976', 'Gene': 'AC073842.19', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs11771139', 'A1': 'A', 'A2': 'G', 'Freq': 0.271984, 'p_SMR_multi': 1.466512e-09, 'Disease': 'AD', 'b_SMR': 0.110756, 'p_HEIDI': 0.005393742}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1368 | Q40 | Are there any specific alleles within the gene COL6A5 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene COL6A5 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'COL6A5' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1401 | Q40 | Are there any specific alleles within the gene RP11-148O21.6 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-148O21.6 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-148O21.6' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.753 | Q40 | Are there any specific alleles within the gene LOC402644 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene LOC402644 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LOC402644' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.259 | Q40 | Are there any specific alleles within the gene AP001257.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene AP001257.1 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs620368
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.20e-10; b: 9.1723e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AP001257.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498261', 'Gene': 'AP001257.1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs620368', 'A1': 'C', 'A2': 'T', 'Freq': 0.0368098, 'p_SMR_multi': 3.201054e-10, 'Disease': 'AD', 'b_SMR': 0.0917232, 'p_HEIDI': 0.03320265}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1687 | Q40 | Are there any specific alleles within the gene MYB associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene MYB that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MYB' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1723 | Q40 | Are there any specific alleles within the gene CLASRP associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene CLASRP that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs1560725
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.09e-14; b: 5.0973e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CLASRP' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637443', 'Gene': 'CLASRP', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs1560725', 'A1': 'C', 'A2': 'T', 'Freq': 0.457055, 'p_SMR_multi': 2.085517e-14, 'Disease': 'AD', 'b_SMR': 0.0509733, 'p_HEIDI': 7.727262e-12}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.544 | Q40 | Are there any specific alleles within the gene ANXA2R associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene ANXA2R that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ANXA2R' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.792 | Q40 | Are there any specific alleles within the gene RP11-405F3.4 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-405F3.4 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-405F3.4' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1484 | Q40 | Are there any specific alleles within the gene ATP13A5-AS1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Skeletal Muscle samples tested, there are no alleles within the gene ATP13A5-AS1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ATP13A5-AS1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.420 | Q40 | Are there any specific alleles within the gene BLID associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene BLID that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'BLID' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1849 | Q40 | Are there any specific alleles within the gene OXR1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene OXR1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OXR1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1920 | Q40 | Are there any specific alleles within the gene RP11-114N19.3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Prefrontal Cortex samples tested, there are no alleles within the gene RP11-114N19.3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-114N19.3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1099 | Q40 | Are there any specific alleles within the gene PHACTR2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene PHACTR2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PHACTR2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.845 | Q40 | Are there any specific alleles within the gene HSD3B7 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene HSD3B7 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs4889606
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.59e-07; b: 1.7771e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HSD3B7' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501472', 'Gene': 'HSD3B7', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs4889606', 'A1': 'G', 'A2': 'A', 'Freq': 0.380368, 'p_SMR_multi': 9.58512e-07, 'Disease': 'AD', 'b_SMR': 0.17771, 'p_HEIDI': 0.004832233}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.68 | Q40 | Are there any specific alleles within the gene RP11-511B23.2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Cortex, Tibial Nerve and Skeletal Muscle samples tested, there are no alleles within the gene RP11-511B23.2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-511B23.2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1698 | Q40 | Are there any specific alleles within the gene USP6NL associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene USP6NL that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs12356673
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.39e-06; b: 1.7194e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'USP6NL' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1497347', 'Gene': 'USP6NL', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs12356673', 'A1': 'C', 'A2': 'A', 'Freq': 0.221881, 'p_SMR_multi': 2.391135e-06, 'Disease': 'AD', 'b_SMR': 0.171939, 'p_HEIDI': 0.1233345}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1733 | Q40 | Are there any specific alleles within the gene RP11-476D10.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene RP11-476D10.1 that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs2638222
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.85e-07; b: 2.7070e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-476D10.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1561428', 'Gene': 'RP11-476D10.1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2638222', 'A1': 'T', 'A2': 'C', 'Freq': 0.266871, 'p_SMR_multi': 7.845953e-07, 'Disease': 'PD', 'b_SMR': 0.02707, 'p_HEIDI': 0.0002787799}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.380 | Q40 | Are there any specific alleles within the gene AC009229.5 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood and Tibial Nerve samples tested, there are no alleles within the gene AC009229.5 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC009229.5' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.240 | Q40 | Are there any specific alleles within the gene LAMTOR4 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene LAMTOR4 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs12878
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.04e-12; b: 1.4646e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LAMTOR4' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495796', 'Gene': 'LAMTOR4', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs12878', 'A1': 'G', 'A2': 'A', 'Freq': 0.366053, 'p_SMR_multi': 2.035005e-12, 'Disease': 'AD', 'b_SMR': 0.146456, 'p_HEIDI': 7.438358e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1172870', 'Gene': 'LAMTOR4',... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.257 | Q40 | Are there any specific alleles within the gene AC007283.5 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene AC007283.5 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC007283.5' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1032 | Q40 | Are there any specific alleles within the gene FMO3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene FMO3 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FMO3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.30 | Q40 | Are there any specific alleles within the gene XAF1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene XAF1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'XAF1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.293 | Q40 | Are there any specific alleles within the gene ATP5F1D associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cortex samples tested, there are no alleles within the gene ATP5F1D that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ATP5F1D' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1886 | Q40 | Are there any specific alleles within the gene RP11-944L7.4 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene RP11-944L7.4 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-944L7.4' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1823 | Q40 | Are there any specific alleles within the gene NDUFAB1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene NDUFAB1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NDUFAB1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.620 | Q40 | Are there any specific alleles within the gene KIF3C associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested, there are no alleles within the gene KIF3C that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'KIF3C' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1667 | Q40 | Are there any specific alleles within the gene GTF2IRD2 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumben... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GTF2IRD2' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.850 | Q40 | Are there any specific alleles within the gene RP11-161D15.3 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene RP11-161D15.3 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-161D15.3' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.215 | Q40 | Are there any specific alleles within the gene C10orf91 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene C10orf91 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C10orf91' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.524 | Q40 | Are there any specific alleles within the gene PDHA2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene PDHA2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PDHA2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.477 | Q40 | Are there any specific alleles within the gene CCDC91 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene CCDC91 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CCDC91' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1327 | Q40 | Are there any specific alleles within the gene USP7 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene USP7 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'USP7' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1433 | Q40 | Are there any specific alleles within the gene RP11-170N11.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Frontal Cortex, Prefrontal Cortex, Cortex and Anterior Cingulate Cortex BA24 samples tested, there are no alleles within the gene RP11-170N11.1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-170N11.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.123 | Q40 | Are there any specific alleles within the gene RP5-1160K1.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Tibial Nerve samples tested, there are no alleles within the gene RP5-1160K1.1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP5-1160K1.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1351 | Q40 | Are there any specific alleles within the gene RUFY3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Tibial Nerve, Skeletal Muscle and Whole Blood samples tested, there are no alleles within the gene RUFY3 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RUFY3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1942 | Q40 | Are there any specific alleles within the gene ODCP associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene ODCP that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ODCP' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1371 | Q40 | Are there any specific alleles within the gene NSMCE1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene NSMCE1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NSMCE1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1171 | Q40 | Are there any specific alleles within the gene LINC00271 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene LINC00271 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LINC00271' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.138 | Q40 | Are there any specific alleles within the gene MDFIC associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood, Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene MDFIC that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MDFIC' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1134 | Q40 | Are there any specific alleles within the gene BST2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene BST2 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'BST2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1874 | Q40 | Are there any specific alleles within the gene LZTS2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene LZTS2 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LZTS2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1241 | Q40 | Are there any specific alleles within the gene PI4KA associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Cerebellum samples tested, there are no alleles within the gene PI4KA that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PI4KA' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1338 | Q40 | Are there any specific alleles within the gene PPP1R26 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene PPP1R26 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PPP1R26' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.958 | Q40 | Are there any specific alleles within the gene SMAD4 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Tibial Nerve, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene SMAD4 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SMAD4' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.929 | Q40 | Are there any specific alleles within the gene MAG associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Liver samples tested, there are no alleles within the gene MAG that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MAG' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.112 | Q40 | Are there any specific alleles within the gene RP11-798G7.5 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene RP11-798G7.5 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.36e-11; b: 3.8054e-01
• rs112995313
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.39e-07; b:... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-798G7.5' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564776', 'Gene': 'RP11-798G7.5', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2532233', 'A1': 'T', 'A2': 'C', 'Freq': 0.238241, 'p_SMR_multi': 2.359444e-11, 'Disease': 'PD', 'b_SMR': 0.380543, 'p_HEIDI': 8.217541e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1640213', 'Gene': 'RP... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1240 | Q40 | Are there any specific alleles within the gene MNDA associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene MNDA that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MNDA' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1921 | Q40 | Are there any specific alleles within the gene DAW1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene DAW1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DAW1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1963 | Q40 | Are there any specific alleles within the gene FUZ associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Whole Blood and Cerebellum samples tested, there are no alleles within the gene FUZ that are significantly associated with an increased susceptibility to developing Alzheimer's Dise... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FUZ' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.214 | Q40 | Are there any specific alleles within the gene AL137059.1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene AL137059.1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AL137059.1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.999 | Q40 | Are there any specific alleles within the gene RP11-119H12.4 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Cortex, Hippocampus, Hypothalamus, Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene RP11-119H12.4 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-119H12.4' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1269 | Q40 | Are there any specific alleles within the gene YIPF3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene YIPF3 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'YIPF3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.592 | Q40 | Are there any specific alleles within the gene NANOG associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene NANOG that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NANOG' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1391 | Q40 | Are there any specific alleles within the gene UBTFL1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene UBTFL1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'UBTFL1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1450 | Q40 | Are there any specific alleles within the gene TRIM9 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Liver samples tested, there are no alleles within the gene TRIM9 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TRIM9' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.279 | Q40 | Are there any specific alleles within the gene HEXB associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene HEXB that are significantly associated with an increased susceptibil... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HEXB' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1507 | Q40 | Are there any specific alleles within the gene OGN associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Brain samples tested, there are no alleles within the gene OGN that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OGN' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1328 | Q40 | Are there any specific alleles within the gene SECISBP2L associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Tibial Nerve and Whole Blood samples tested, there are no alleles within the gene SECISBP2L that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SECISBP2L' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1271 | Q40 | Are there any specific alleles within the gene AC004837.5 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene AC004837.5 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC004837.5' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1820 | Q40 | Are there any specific alleles within the gene BCAS2P2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene BCAS2P2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'BCAS2P2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.273 | Q40 | Are there any specific alleles within the gene TATDN2P3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Skeletal Muscle samples tested, there are no alleles within the gene TATDN2P3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TATDN2P3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1863 | Q40 | Are there any specific alleles within the gene ZNF35 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene ZNF35 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF35' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.578 | Q40 | Are there any specific alleles within the gene C22orf43 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Cerebellum and Nucleus Accumbens Basal samples tes... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C22orf43' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.638 | Q40 | Are there any specific alleles within the gene CCDC33 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene CCDC33 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CCDC33' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.713 | Q40 | Are there any specific alleles within the gene AC019118.2 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene AC019118.2 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC019118.2' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1529 | Q40 | Are there any specific alleles within the gene TMEM175 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 5 alleles within the gene TMEM175 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs11248057
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.33e-11; b: 4.9539e-01
• rs11248059
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.26e-11; b: 2.36... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TMEM175' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_996290', 'Gene': 'TMEM175', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs11248057', 'A1': 'G', 'A2': 'C', 'Freq': 0.285276, 'p_SMR_multi': 4.328358e-11, 'Disease': 'PD', 'b_SMR': 0.495391, 'p_HEIDI': 0.6479261}, {'UUID': 'NDD_SMR_genes_all_update_text_996291', 'Gene': 'TMEM175', '... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.627 | Q40 | Are there any specific alleles within the gene UHRF1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene UHRF1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'UHRF1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1991 | Q40 | Are there any specific alleles within the gene CTB-31O20.6 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene CTB-31O20.6 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTB-31O20.6' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.813 | Q40 | Are there any specific alleles within the gene RP11-567L7.5 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene RP11-567L7.5 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-567L7.5' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.309 | Q40 | Are there any specific alleles within the gene MMRN1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 11 alleles within the gene MMRN1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. Here are the top 10:
• rs79093919
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.45e-15; b: 1.5153e-01
• Prefrontal Cortex: Adjusted SMR multi-SN... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MMRN1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1430395', 'Gene': 'MMRN1', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs79093919', 'A1': 'G', 'A2': 'T', 'Freq': 0.0388548, 'p_SMR_multi': 8.451387e-15, 'Disease': 'PD', 'b_SMR': 0.151526, 'p_HEIDI': 1.293812e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1140477', '... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.550 | Q40 | Are there any specific alleles within the gene RSPH4A associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Tibial Nerve and Skeletal Muscle samples tested, there are no alleles within the gene RSPH4A that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RSPH4A' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1606 | Q40 | Are there any specific alleles within the gene AC016717.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Skeletal Muscle samples tested, there are no alleles within the gene AC016717.1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC016717.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1743 | Q40 | Are there any specific alleles within the gene TRIM35 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene TRIM35 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs7830415
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.29e-07; b: 1.1015e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TRIM35' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496304', 'Gene': 'TRIM35', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs7830415', 'A1': 'A', 'A2': 'T', 'Freq': 0.443763, 'p_SMR_multi': 2.29082e-07, 'Disease': 'AD', 'b_SMR': 0.0110148, 'p_HEIDI': 4.343769e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.50 | Q40 | Are there any specific alleles within the gene GRIN3A associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain and Whole Blood samples tested, there are no alleles within the gene GRIN3A that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GRIN3A' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
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