uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q4.129 | Q4 | What drugs target the gene C5AR1? | The drug that targets C5AR1 is Avacopan. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%C5AR1 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_5921', 'drugName': 'Avacopan', 'newLinkedTargets_string': 'C5AR1 (ENSG00000197405)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4794', 'drugName': 'Avdoralimab', 'newLinkedTargets_string': 'C5AR1 (ENSG00000197405)', 'drugIsApproved': False, 'maxClinic... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1512 | Q4 | What drugs target the gene TXNRD1? | The drugs that target TXNRD1 are Arsenic Trioxide and Aurothioglucose. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%TXNRD1 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_975', 'drugName': 'Arsenic Trioxide', 'newLinkedTargets_string': 'TXNRD1 (ENSG00000198431)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5394', 'drugName': 'Aurothioglucose', 'newLinkedTargets_string': 'TXNRD1 (ENSG00000198431)', 'drugIsApproved': True... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.932 | Q4 | What drugs target the gene NCBP1? | There are no approved drugs targeting NCBP1, but the drug Obefazimod, which potentially targets this gene, is currently undergoing clinical trials. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%NCBP1 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_3077', 'drugName': 'Obefazimod', 'newLinkedTargets_string': 'NCBP2 (ENSG00000114503), NCBP1 (ENSG00000136937)', 'drugIsApproved': False, 'maxClinicalTrialPhase': 2}] | general | Select, Similarity Search, Order By | Genetic Target |
Q4.986 | Q4 | What drugs target the gene NOS1? | There are no FDA approved drugs targeting the gene NOS1. However, the following drugs, which potentially target this gene, are currently in various clinical trial stages: Tilarginine and Tilarginine Acetate. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%NOS1 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_890', 'drugName': 'Tilarginine', 'newLinkedTargets_string': 'NOS1 (ENSG00000089250), NOS2 (ENSG00000007171), NOS3 (ENSG00000164867)', 'drugIsApproved': False, 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1662', 'drugName': 'Tilarginine Acetate', 'newLinkedTargets_string': 'NOS... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1507 | Q4 | What drugs target the gene TUBB6? | The drugs that target TUBB6 are Polatuzumab Vedotin, Cabazitaxel, Vinflunine, Brentuximab Vedotin, Docetaxel, Belantamab Mafodotin, Paclitaxel, Vinorelbine, Ixabepilone, Enfortumab Vedotin, Eribulin Mesylate, Vincristine Sulfate, Tisotumab Vedotin, Vinblastine, Colchicine, Vincristine, Eribulin, Trastuzumab Emtansine, ... | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%TUBB6 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_1084', 'drugName': 'Brentuximab Vedotin', 'newLinkedTargets_string': 'TNFRSF8 (ENSG00000120949), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.192 | Q4 | What drugs target the gene CCND1? | The drug that targets CCND1 is Palbociclib. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%CCND1 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_2461', 'drugName': 'Palbociclib', 'newLinkedTargets_string': 'CCND1 (ENSG00000110092), CDK6 (ENSG00000105810), CDK4 (ENSG00000135446)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2460', 'drugName': 'Palbociclib', 'newLinkedTargets_string': 'CCND1 (ENS... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1147 | Q4 | What drugs target the gene PSCA? | There are no approved drugs targeting PSCA, but the drug Mk-4721, which potentially targets this gene, is currently undergoing clinical trials. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%PSCA %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_5916', 'drugName': 'Mk-4721', 'newLinkedTargets_string': 'PSCA (ENSG00000167653)', 'drugIsApproved': False, 'maxClinicalTrialPhase': 2}] | general | Select, Similarity Search, Order By | Genetic Target |
Q4.998 | Q4 | What drugs target the gene NPR1? | The drug that targets NPR1 is Nesiritide. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%NPR1 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_3389', 'drugName': 'Nesiritide', 'newLinkedTargets_string': 'NPR1 (ENSG00000169418)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2532', 'drugName': 'Carperitide', 'newLinkedTargets_string': 'NPR2 (ENSG00000159899), NPR1 (ENSG00000169418), NPR3 (ENSG00... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1500 | Q4 | What drugs target the gene TUBB? | The drugs that target TUBB are Polatuzumab Vedotin, Cabazitaxel, Vinflunine, Brentuximab Vedotin, Docetaxel, Belantamab Mafodotin, Paclitaxel, Vinorelbine, Ixabepilone, Enfortumab Vedotin, Eribulin Mesylate, Vincristine Sulfate, Tisotumab Vedotin, Vinblastine, Colchicine, Vincristine, Eribulin, Trastuzumab Emtansine, V... | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%TUBB %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_1084', 'drugName': 'Brentuximab Vedotin', 'newLinkedTargets_string': 'TNFRSF8 (ENSG00000120949), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1283 | Q4 | What drugs target the gene RPS18? | The drug that targets RPS18 is Ataluren. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%RPS18 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.610 | Q4 | What drugs target the gene HSP90AB1? | There are no FDA approved drugs targeting the gene HSP90AB1. However, the following drugs, which potentially target this gene, are currently in various clinical trial stages: Onalespib, Retaspimycin Hydrochloride, Ganetespib, Tanespimycin, Snx 5422, Biib021, Retaspimycin, Luminespib, Alvespimycin, and Cd24Fc. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%HSP90AB1 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_1279', 'drugName': 'Retaspimycin Hydrochloride', 'newLinkedTargets_string': 'HSP90AA1 (ENSG00000080824), HSP90AB1 (ENSG00000096384)', 'drugIsApproved': False, 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2657', 'drugName': 'Tanespimycin', 'newLinkedTargets_string': 'HSP90AA1 (... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.182 | Q4 | What drugs target the gene CASP7? | There are no approved drugs targeting CASP7, but the drug Emricasan, which potentially targets this gene, is currently undergoing clinical trials. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%CASP7 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_45', 'drugName': 'Emricasan', 'newLinkedTargets_string': 'CASP4 (ENSG00000196954), CASP9 (ENSG00000132906), CASP3 (ENSG00000164305), CASP5 (ENSG00000137757), CASP6 (ENSG00000138794), CASP7 (ENSG00000165806), CASP8 (ENSG00000064012), CASP1 (ENSG00000137752), CASP2 (ENSG00000106144), CASP10 ... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.303 | Q4 | What drugs target the gene COL5A2? | The drugs that target COL5A2 are Collagenase Clostridium Histolyticum and Ocriplasmin. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%COL5A2 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_5818', 'drugName': 'Ocriplasmin', 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156), COL11A1 (ENSG0000006071... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.499 | Q4 | What drugs target the gene GABRB1? | The drugs that target GABRB1 are Meprobamate, Acamprosate Calcium, Enflurane, Methohexital, Metharbital, Butabarbital, Flurazepam Hydrochloride, Pentobarbital Sodium, Acamprosate, Primidone, Temazepam, Flunitrazepam, Ganaxolone, Diazepam, Methyprylon, Thiopental, Clonazepam, Topiramate, Remimazolam Besylate, Brexanolon... | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%GABRB1 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_3142', 'drugName': 'Lorazepam', 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677), GABRP (ENSG00000094755)... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1324 | Q4 | What drugs target the gene RYR3? | The drugs that target RYR3 are Dantrolene and Dantrolene Sodium. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%RYR3 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_4505', 'drugName': 'Dantrolene Sodium', 'newLinkedTargets_string': 'RYR3 (ENSG00000198838), RYR1 (ENSG00000196218)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4504', 'drugName': 'Dantrolene Sodium', 'newLinkedTargets_string': 'RYR3 (ENSG00000198838),... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1288 | Q4 | What drugs target the gene RPS23? | The drug that targets RPS23 is Ataluren. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%RPS23 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1268 | Q4 | What drugs target the gene RPL7? | The drug that targets RPL7 is Ataluren. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%RPL7 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG00000083845), RPS7 (ENSG... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.520 | Q4 | What drugs target the gene GIPR? | The drug that targets GIPR is Tirzepatide. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%GIPR %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_5134', 'drugName': 'Tirzepatide', 'newLinkedTargets_string': 'GIPR (ENSG00000010310), GLP1R (ENSG00000112164)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5135', 'drugName': 'Tirzepatide', 'newLinkedTargets_string': 'GIPR (ENSG00000010310), GLP1R (ENS... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1075 | Q4 | What drugs target the gene PIK3CA? | The drugs that target PIK3CA are Alpelisib, Copanlisib Hydrochloride, and Copanlisib. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%PIK3CA %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_722', 'drugName': 'Alpelisib', 'newLinkedTargets_string': 'PIK3CA (ENSG00000121879)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1214', 'drugName': 'Copanlisib Hydrochloride', 'newLinkedTargets_string': 'PIK3CA (ENSG00000121879), PIK3CD (ENSG000001716... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.478 | Q4 | What drugs target the gene FOLH1? | The drugs that target FOLH1 are Vipivotide Tetraxetan Lutetium and Lutetium Lu 177 Vipivotide Tetraxetan. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%FOLH1 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_5876', 'drugName': 'Lutetium Lu 177 Vipivotide Tetraxetan', 'newLinkedTargets_string': 'FOLH1 (ENSG00000086205)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5373', 'drugName': 'Vipivotide Tetraxetan Lutetium', 'newLinkedTargets_string': 'FOLH1 (ENSG00... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.159 | Q4 | What drugs target the gene CACNB4? | The drugs that target CACNB4 are Gabapentin, Terodiline Hydrochloride, Phloroglucinol, Suloctidil, Pregabalin, Gabapentin Enacarbil, Bepridil Hydrochloride, Bepridil, and Terodiline. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%CACNB4 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_142', 'drugName': 'Gabapentin', 'newLinkedTargets_string': 'CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067), CACNA2D3 (ENSG00000157445), CACNA1S (ENSG00000081248), CACNA2D2 (ENSG00000007402), CACNA1D (ENSG00000157388), CACNA1A (ENSG00000141837), CACNA1B (EN... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1204 | Q4 | What drugs target the gene PTPN11? | There are no approved drugs targeting PTPN11, but the drug Batoprotafib, which potentially targets this gene, is currently undergoing clinical trials. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%PTPN11 %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_6363', 'drugName': 'Batoprotafib', 'newLinkedTargets_string': 'PTPN11 (ENSG00000179295)', 'drugIsApproved': False, 'maxClinicalTrialPhase': 1}] | general | Select, Similarity Search, Order By | Genetic Target |
Q4.17 | Q4 | What drugs target the gene ADA? | The drug that targets ADA is Pentostatin. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%ADA %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_251', 'drugName': 'Pentostatin', 'newLinkedTargets_string': 'ADA (ENSG00000196839)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5186', 'drugName': 'Coformycin', 'newLinkedTargets_string': 'ADA (ENSG00000196839)', 'drugIsApproved': False, 'maxClinicalT... | general | Select, Similarity Search, Order By | Genetic Target |
Q4.1078 | Q4 | What drugs target the gene PIK3CG? | The drug that targets PIK3CG is Duvelisib. | SELECT DISTINCT UUID, drugName, newLinkedTargets_string, drugIsApproved, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE '%PIK3CG %'
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100 | [{'UUID': 'DrugGeneTargets_v2_1892', 'drugName': 'Duvelisib', 'newLinkedTargets_string': 'PIK3CG (ENSG00000105851), PIK3CD (ENSG00000171608)', 'drugIsApproved': True, 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1893', 'drugName': 'Duvelisib', 'newLinkedTargets_string': 'PIK3CG (ENSG00000105851), PIK3CD (E... | general | Select, Similarity Search, Order By | Genetic Target |
Q40.589 | Q40 | Are there any specific alleles within the gene PKD1P6 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene PKD1P6 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PKD1P6' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1868 | Q40 | Are there any specific alleles within the gene RBIS associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cortex samples tested, there are no alleles within the gene RBIS that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RBIS' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1061 | Q40 | Are there any specific alleles within the gene PRSS29P associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene PRSS29P that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PRSS29P' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1084 | Q40 | Are there any specific alleles within the gene SLC44A4 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene SLC44A4 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs2242664
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.27e-08; b: 1.2421e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC44A4' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621257', 'Gene': 'SLC44A4', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2242664', 'A1': 'C', 'A2': 'T', 'Freq': 0.424335, 'p_SMR_multi': 9.265856e-08, 'Disease': 'AD', 'b_SMR': 0.0124207, 'p_HEIDI': 0.2009325}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.925 | Q40 | Are there any specific alleles within the gene YWHAH associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene YWHAH that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'YWHAH' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.73 | Q40 | Are there any specific alleles within the gene LYRM1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene LYRM1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LYRM1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.435 | Q40 | Are there any specific alleles within the gene TENM3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene TENM3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TENM3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.911 | Q40 | Are there any specific alleles within the gene STX12 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene STX12 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'STX12' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.922 | Q40 | Are there any specific alleles within the gene RIMKLB associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood, Tibial Nerve and Skeletal Muscle samples tested, there are no alleles within the gene RIMKLB that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RIMKLB' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1679 | Q40 | Are there any specific alleles within the gene CTB-23I7.1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene CTB-23I7.1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTB-23I7.1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1272 | Q40 | Are there any specific alleles within the gene FAM215B associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | Yes, there are 4 alleles within the gene FAM215B that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy:
• rs17692129
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.76e-17; b: 1.0838e+00
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.73e-12; b: 1.278... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM215B' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579431', 'Gene': 'FAM215B', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs17692129', 'A1': 'T', 'A2': 'C', 'Freq': 0.340491, 'p_SMR_multi': 1.7603150000000002e-17, 'Disease': 'PSP', 'b_SMR': 1.08383, 'p_HEIDI': 3.359908e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1714165', 'Gene... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1094 | Q40 | Are there any specific alleles within the gene TRAJ2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene TRAJ2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TRAJ2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.389 | Q40 | Are there any specific alleles within the gene MESP2 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested, there are no alleles within the gene MESP2 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MESP2' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.841 | Q40 | Are there any specific alleles within the gene SGTB associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cortex, Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested, there are no alleles within the gene SGTB that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SGTB' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.774 | Q40 | Are there any specific alleles within the gene RYR3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene RYR3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RYR3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1805 | Q40 | Are there any specific alleles within the gene AC009487.5 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene AC009487.5 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC009487.5' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1992 | Q40 | Are there any specific alleles within the gene TRIM40 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene TRIM40 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs115938232
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.57e-07; b: 5.3831e-02
• rs114882073
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.83e-07; b: 5.2... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TRIM40' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620281', 'Gene': 'TRIM40', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs115938232', 'A1': 'G', 'A2': 'A', 'Freq': 0.0490798, 'p_SMR_multi': 3.571278e-07, 'Disease': 'AD', 'b_SMR': 0.0538314, 'p_HEIDI': 0.7820669}, {'UUID': 'NDD_SMR_genes_all_update_text_620283', 'Gene': 'TRIM40', ... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1066 | Q40 | Are there any specific alleles within the gene RP11-20I23.8 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Tibial Nerve, Skeletal Muscle and Cerebellum samples tested, there are no alleles within the gene RP11-20I23.8 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-20I23.8' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.58 | Q40 | Are there any specific alleles within the gene RABL3 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RABL3 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RABL3' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1688 | Q40 | Are there any specific alleles within the gene SNORA73 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex and Whole Brain samples tested, there are no alleles within the gene SNORA73 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SNORA73' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1955 | Q40 | Are there any specific alleles within the gene IGF2BP1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene IGF2BP1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'IGF2BP1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1218 | Q40 | Are there any specific alleles within the gene IGFN1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene IGFN1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'IGFN1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1680 | Q40 | Are there any specific alleles within the gene POU2AF1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene POU2AF1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'POU2AF1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1975 | Q40 | Are there any specific alleles within the gene GIF associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene GIF that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GIF' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.213 | Q40 | Are there any specific alleles within the gene JAZF1-AS1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene JAZF1-AS1 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs73300665
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.61e-06; b: 7.0809e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'JAZF1-AS1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1198595', 'Gene': 'JAZF1-AS1', 'Omic_tissue': 'Prefrontal Cortex', 'topSNP': 'rs73300665', 'A1': 'A', 'A2': 'G', 'Freq': 0.0879346, 'p_SMR_multi': 1.608877e-06, 'Disease': 'AD', 'b_SMR': 0.0708091, 'p_HEIDI': 0.004842932}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1534 | Q40 | Are there any specific alleles within the gene RP11-200A1.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Liver samples tested, there are no alleles within the gene RP11-200A1.1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-200A1.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1135 | Q40 | Are there any specific alleles within the gene SLC6A19 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Liver samples tested, there are no alleles within the gene SLC6A19 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC6A19' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.131 | Q40 | Are there any specific alleles within the gene C2orf66 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Blood, Cortex, Prefrontal Cortex and Tibial Nerve samples tested, there are no alleles within the gene C2orf66 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C2orf66' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.819 | Q40 | Are there any specific alleles within the gene RP11-10N16.3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene RP11-10N16.3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-10N16.3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1282 | Q40 | Are there any specific alleles within the gene RNF144A-AS1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Caudate Basal Ganglia, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested, there are no alleles within the gene RNF144A-AS1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RNF144A-AS1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1872 | Q40 | Are there any specific alleles within the gene JMJD7 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Whole Blood and Cerebellum samples tested, there are no alleles within the gene JMJD7 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'JMJD7' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.438 | Q40 | Are there any specific alleles within the gene TNPO1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene TNPO1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TNPO1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.417 | Q40 | Are there any specific alleles within the gene RASL11B associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene RASL11B that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RASL11B' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1504 | Q40 | Are there any specific alleles within the gene ISLR associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Skeletal Muscle samples tested, there are no alleles within the gene ISLR that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ISLR' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.234 | Q40 | Are there any specific alleles within the gene CRHR1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | Yes, there are 5 alleles within the gene CRHR1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.62e-23; b: 2.9865e+00
• rs393152
• Cortex: Adjusted SMR multi-SNP P-value: 1.15e-20; b: 4.14... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CRHR1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041720', 'Gene': 'CRHR1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs169201', 'A1': 'G', 'A2': 'A', 'Freq': 0.219836, 'p_SMR_multi': 5.624302000000001e-23, 'Disease': 'PSP', 'b_SMR': 2.98649, 'p_HEIDI': 4.073966e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1154394', 'Gene': 'C... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1708 | Q40 | Are there any specific alleles within the gene RP11-798K23.5 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellar Hemisphere, Whole Blood, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested, there are no alleles within the gene RP11-798K23.5 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-798K23.5' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.895 | Q40 | Are there any specific alleles within the gene PPP2R5D associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene PPP2R5D that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PPP2R5D' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1625 | Q40 | Are there any specific alleles within the gene UNC93B6 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Prefrontal Cortex, Cortex and Caudate Basal Ganglia samples tested, there are no alleles within the gene UNC93B6 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'UNC93B6' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.699 | Q40 | Are there any specific alleles within the gene RP11-1186N24.5 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene RP11-1186N24.5 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-1186N24.5' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1769 | Q40 | Are there any specific alleles within the gene ERBB2IP associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene ERBB2IP that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ERBB2IP' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.301 | Q40 | Are there any specific alleles within the gene IGLV2-34 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene IGLV2-34 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'IGLV2-34' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1399 | Q40 | Are there any specific alleles within the gene CLPTM1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene CLPTM1 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs112704499
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.72e-11; b: 8.1064e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CLPTM1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_122472', 'Gene': 'CLPTM1', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs112704499', 'A1': 'A', 'A2': 'G', 'Freq': 0.295501, 'p_SMR_multi': 2.721346e-11, 'Disease': 'AD', 'b_SMR': 0.0810636, 'p_HEIDI': 2.477034e-09}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1987 | Q40 | Are there any specific alleles within the gene FOXI2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene FOXI2 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FOXI2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.102 | Q40 | Are there any specific alleles within the gene AC004528.1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene AC004528.1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC004528.1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.831 | Q40 | Are there any specific alleles within the gene BST1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene BST1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'BST1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.359 | Q40 | Are there any specific alleles within the gene EZH2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Blood, Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene EZH2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'EZH2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.114 | Q40 | Are there any specific alleles within the gene AC080125.1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene AC080125.1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC080125.1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1440 | Q40 | Are there any specific alleles within the gene NAPSB associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum a... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NAPSB' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1840 | Q40 | Are there any specific alleles within the gene SLC18B1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene SLC18B1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC18B1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.952 | Q40 | Are there any specific alleles within the gene CLIC1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood and Cortex samples tested, there are no alleles within the gene CLIC1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CLIC1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1186 | Q40 | Are there any specific alleles within the gene PLCD4 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Liver samples tested, there are no alleles within the gene PLCD4 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PLCD4' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.456 | Q40 | Are there any specific alleles within the gene RP11-110I1.11 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-110I1.11 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-110I1.11' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.876 | Q40 | Are there any specific alleles within the gene MADD associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene MADD that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs35233100
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.67e-06; b: 6.4298e-03 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MADD' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1394231', 'Gene': 'MADD', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs35233100', 'A1': 'T', 'A2': 'C', 'Freq': 0.0490798, 'p_SMR_multi': 1.671309e-06, 'Disease': 'AD', 'b_SMR': 0.00642979, 'p_HEIDI': 0.0008438054}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1545 | Q40 | Are there any specific alleles within the gene PKD2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene PKD2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PKD2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1701 | Q40 | Are there any specific alleles within the gene AP001652.1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene AP001652.1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AP001652.1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1436 | Q40 | Are there any specific alleles within the gene NDUFB3 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene NDUFB3 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NDUFB3' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.915 | Q40 | Are there any specific alleles within the gene CR2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene CR2 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs1019830
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 8.03e-09; b: 1.4337e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CR2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1195475', 'Gene': 'CR2', 'Omic_tissue': 'Prefrontal Cortex', 'topSNP': 'rs1019830', 'A1': 'A', 'A2': 'T', 'Freq': 0.674847, 'p_SMR_multi': 8.027354e-09, 'Disease': 'AD', 'b_SMR': 0.143374, 'p_HEIDI': 0.0001062646}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.310 | Q40 | Are there any specific alleles within the gene CDKAL1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene CDKAL1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CDKAL1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1257 | Q40 | Are there any specific alleles within the gene SH2D4B associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene SH2D4B that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs34533074
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.23e-08; b: 2.5244e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SH2D4B' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_572663', 'Gene': 'SH2D4B', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs34533074', 'A1': 'A', 'A2': 'G', 'Freq': 0.0705521, 'p_SMR_multi': 4.234473e-08, 'Disease': 'AD', 'b_SMR': 0.0252438, 'p_HEIDI': 0.00900114}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1409 | Q40 | Are there any specific alleles within the gene RIN3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene RIN3 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs4904944
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.23e-06; b: 7.3004e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RIN3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1395551', 'Gene': 'RIN3', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs4904944', 'A1': 'C', 'A2': 'G', 'Freq': 0.351738, 'p_SMR_multi': 1.23213e-06, 'Disease': 'AD', 'b_SMR': 0.0730039, 'p_HEIDI': 4.214218e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.618 | Q40 | Are there any specific alleles within the gene DLEU2L associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve and Whole Brain samples tested, there are no alleles within the gene DLEU2L that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DLEU2L' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1479 | Q40 | Are there any specific alleles within the gene TSC22D4 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene TSC22D4 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs67163493
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.75e-11; b: 1.0754e-03 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TSC22D4' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_586004', 'Gene': 'TSC22D4', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs67163493', 'A1': 'T', 'A2': 'C', 'Freq': 0.197342, 'p_SMR_multi': 5.747145e-11, 'Disease': 'AD', 'b_SMR': 0.00107538, 'p_HEIDI': 0.0006834187}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.250 | Q40 | Are there any specific alleles within the gene ADORA2B associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene ADORA2B that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs1045599
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.44e-06; b: 1.3856e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ADORA2B' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1435715', 'Gene': 'ADORA2B', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs1045599', 'A1': 'C', 'A2': 'T', 'Freq': 0.428425, 'p_SMR_multi': 2.440225e-06, 'Disease': 'PD', 'b_SMR': 0.138559, 'p_HEIDI': 0.000119655}, {'UUID': 'NDD_SMR_genes_all_update_text_1370421', 'G... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.734 | Q40 | Are there any specific alleles within the gene CENPQ associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala a... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CENPQ' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.311 | Q40 | Are there any specific alleles within the gene ZNF716 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain and Cortex samples tested, there are no alleles within the gene ZNF716 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF716' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.236 | Q40 | Are there any specific alleles within the gene RPTOR associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene RPTOR that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RPTOR' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.72 | Q40 | Are there any specific alleles within the gene ADCY10P1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene ADCY10P1 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs78609059
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.61e-08; b: 1.5348e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ADCY10P1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_622643', 'Gene': 'ADCY10P1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs78609059', 'A1': 'A', 'A2': 'T', 'Freq': 0.137014, 'p_SMR_multi': 3.61254e-08, 'Disease': 'AD', 'b_SMR': 0.0153477, 'p_HEIDI': 8.750358e-10}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.896 | Q40 | Are there any specific alleles within the gene ZNF668 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene ZNF668 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs2303222
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.05e-08; b: 1.0960e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF668' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501476', 'Gene': 'ZNF668', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2303222', 'A1': 'C', 'A2': 'T', 'Freq': 0.397751, 'p_SMR_multi': 8.050569e-08, 'Disease': 'AD', 'b_SMR': 0.109599, 'p_HEIDI': 0.002467109}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1754 | Q40 | Are there any specific alleles within the gene CBLL1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene CBLL1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CBLL1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.712 | Q40 | Are there any specific alleles within the gene TIAM1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Multi Ancestry Whole Brain, Putamen Basal Ganglia and Cerebellum samples tested, there are no alleles within the gene TIAM1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TIAM1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1383 | Q40 | Are there any specific alleles within the gene ZNF432 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene ZNF432 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF432' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1329 | Q40 | Are there any specific alleles within the gene ADAM10 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene ADAM10 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs7161799
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.33e-06; b: 1.1895e-02
• rs1427280
• Cortex: Adjusted SMR multi-SNP P-value: 2.62e-06; b: 1.2361e-01
| SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ADAM10' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1500785', 'Gene': 'ADAM10', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs7161799', 'A1': 'T', 'A2': 'C', 'Freq': 0.0879346, 'p_SMR_multi': 1.325576e-06, 'Disease': 'AD', 'b_SMR': 0.0118947, 'p_HEIDI': 0.2374332}, {'UUID': 'NDD_SMR_genes_all_update_text_1109990', 'Gene': 'ADAM10', ... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.624 | Q40 | Are there any specific alleles within the gene OCIAD1-AS1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene OCIAD1-AS1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OCIAD1-AS1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1464 | Q40 | Are there any specific alleles within the gene RP13-98N21.3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex and Whole Brain samples tested, there are no alleles within the gene RP13-98N21.3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP13-98N21.3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1556 | Q40 | Are there any specific alleles within the gene CR1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 4 alleles within the gene CR1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs679515
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.09e-15; b: 1.4662e-01
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.08e-12; b: 2.... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CR1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1389608', 'Gene': 'CR1', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs679515', 'A1': 'T', 'A2': 'C', 'Freq': 0.171779, 'p_SMR_multi': 2.085436e-15, 'Disease': 'AD', 'b_SMR': 0.146622, 'p_HEIDI': 9.09245e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1105231', 'Gene':... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.708 | Q40 | Are there any specific alleles within the gene ART4 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood and Cortex samples tested, there are no alleles within the gene ART4 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ART4' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
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