uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q40.1481 | Q40 | Are there any specific alleles within the gene TPD52L2 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene TPD52L2 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TPD52L2' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.109 | Q40 | Are there any specific alleles within the gene RP11-561C5.5 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex, Tibial Nerve, Substantia nigra and Amygdala samples tested, there are no alleles within the gene RP11-561C5.5 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-561C5.5' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.353 | Q40 | Are there any specific alleles within the gene RPL19 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RPL19 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RPL19' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.241 | Q40 | Are there any specific alleles within the gene GOSR2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested, there are no alleles within the gene GOSR2 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GOSR2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.216 | Q40 | Are there any specific alleles within the gene JAM2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene JAM2 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'JAM2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1827 | Q40 | Are there any specific alleles within the gene RIPK1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene RIPK1 that are significantly associated with an increased susceptibility to developing Lewy Body D... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RIPK1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1138 | Q40 | Are there any specific alleles within the gene CABP4 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum samples tested, there are no alleles within the gene CABP4 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CABP4' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.800 | Q40 | Are there any specific alleles within the gene FHOD3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Blood, Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Putamen Basal Ganglia and Whole Brain samples tested, there are no alleles within the gene FHOD3 that are significantly associated with an increased susceptibility to de... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FHOD3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1123 | Q40 | Are there any specific alleles within the gene RP11-98I9.4 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum a... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-98I9.4' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1583 | Q40 | Are there any specific alleles within the gene RP11-8P11.3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Caudate Basal Ganglia, Anterior Cingulate Cortex BA24, Cerebellum and Nucleus Accumbens Basal samples tested, there are no alleles within the gene RP11-8P11.3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-8P11.3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1672 | Q40 | Are there any specific alleles within the gene TREML5P associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene TREML5P that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs6458200
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.12e-10; b: 8.1232e-03 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TREML5P' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494872', 'Gene': 'TREML5P', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs6458200', 'A1': 'T', 'A2': 'G', 'Freq': 0.232106, 'p_SMR_multi': 1.116296e-10, 'Disease': 'AD', 'b_SMR': 0.0081232, 'p_HEIDI': 0.0002742431}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.529 | Q40 | Are there any specific alleles within the gene OR13D1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene OR13D1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR13D1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.235 | Q40 | Are there any specific alleles within the gene NDST3 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex and Tibial Nerve samples tested, there are no alleles within the gene NDST3 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NDST3' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.651 | Q40 | Are there any specific alleles within the gene OR2B7P associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene OR2B7P that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR2B7P' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1509 | Q40 | Are there any specific alleles within the gene CCL11 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene CCL11 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CCL11' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.539 | Q40 | Are there any specific alleles within the gene RP11-156P1.3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum a... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-156P1.3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1753 | Q40 | Are there any specific alleles within the gene RP11-271C24.2 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene RP11-271C24.2 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-271C24.2' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.610 | Q40 | Are there any specific alleles within the gene PLAC9 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene PLAC9 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs745182
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.90e-07; b: 2.8735e-02
• rs2784768
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.14e-06; b: 2.8469e-0... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PLAC9' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_572609', 'Gene': 'PLAC9', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs745182', 'A1': 'C', 'A2': 'T', 'Freq': 0.384458, 'p_SMR_multi': 1.896037e-07, 'Disease': 'AD', 'b_SMR': 0.028735, 'p_HEIDI': 0.0007834608}, {'UUID': 'NDD_SMR_genes_all_update_text_572608', 'Gene': 'PLAC9', 'Omi... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1780 | Q40 | Are there any specific alleles within the gene RRM1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucl... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RRM1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1083 | Q40 | Are there any specific alleles within the gene CTC-559E9.10 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellar Hemisphere and Cerebellum samples tested, there are no alleles within the gene CTC-559E9.10 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTC-559E9.10' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1407 | Q40 | Are there any specific alleles within the gene BCAP29 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cortex, Multi Ancestry Whole Brain, Whole Blood and Putamen Basal Ganglia samples tested, there are no alleles within the gene BCAP29 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'BCAP29' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.62 | Q40 | Are there any specific alleles within the gene RNA5SP122 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellar Hemisphere and Cerebellum samples tested, there are no alleles within the gene RNA5SP122 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RNA5SP122' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1643 | Q40 | Are there any specific alleles within the gene NUCB1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Cerebellum samples tested, there are no alleles within the gene NUCB1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NUCB1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.95 | Q40 | Are there any specific alleles within the gene ARHGAP5-AS1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene ARHGAP5-AS1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ARHGAP5-AS1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.673 | Q40 | Are there any specific alleles within the gene ZNF85 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Cerebellum, Basal Ganglia, Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Skeletal Muscle, Multi Ancestry Whole Brain, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene ZNF85 that are s... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF85' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.284 | Q40 | Are there any specific alleles within the gene RP11-364L4.3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-364L4.3 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-364L4.3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1796 | Q40 | Are there any specific alleles within the gene CTD-2587H24.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Skeletal Muscle samples tested, there are no alleles within the gene CTD-2587H24.1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTD-2587H24.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.364 | Q40 | Are there any specific alleles within the gene DNAJB13 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene DNAJB13 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DNAJB13' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1468 | Q40 | Are there any specific alleles within the gene S100A10 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Hypothalamus, Liver, Anterior Cingulate Cortex BA24 and Nucleus Accumbens Basal samples tested, there are no alleles within the gene S100A10 that are significantly associate... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'S100A10' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1169 | Q40 | Are there any specific alleles within the gene TREML3P associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene TREML3P that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs12529029
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.24e-12; b: 5.4664e-03 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TREML3P' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494870', 'Gene': 'TREML3P', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs12529029', 'A1': 'C', 'A2': 'G', 'Freq': 0.232106, 'p_SMR_multi': 4.235785e-12, 'Disease': 'AD', 'b_SMR': 0.0054664, 'p_HEIDI': 0.005011636}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.854 | Q40 | Are there any specific alleles within the gene RP11-167N24.6 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene RP11-167N24.6 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-167N24.6' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1379 | Q40 | Are there any specific alleles within the gene KIF28P associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene KIF28P that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'KIF28P' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.113 | Q40 | Are there any specific alleles within the gene EPHA1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene EPHA1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'EPHA1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.43 | Q40 | Are there any specific alleles within the gene RP5-1022P6.2 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene RP5-1022P6.2 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP5-1022P6.2' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.128 | Q40 | Are there any specific alleles within the gene PRSS12 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene PRSS12 that are significantly associated with an increased susceptibility to developing Lewy ... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PRSS12' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.207 | Q40 | Are there any specific alleles within the gene DHDH associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Blood, Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene DHDH that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DHDH' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.53 | Q40 | Are there any specific alleles within the gene ZSCAN18 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene ZSCAN18 that are significantly associated with an increased susceptibility to developing Progressive supranuclea... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZSCAN18' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.551 | Q40 | Are there any specific alleles within the gene LRRC37A associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene LRRC37A that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs17698176
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.68e-07; b: 7.4373e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LRRC37A' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564789', 'Gene': 'LRRC37A', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs17698176', 'A1': 'G', 'A2': 'T', 'Freq': 0.228016, 'p_SMR_multi': 9.67693e-07, 'Disease': 'PD', 'b_SMR': 0.0743727, 'p_HEIDI': 5.914575e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.71 | Q40 | Are there any specific alleles within the gene POMGNT1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene POMGNT1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'POMGNT1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1816 | Q40 | Are there any specific alleles within the gene TMEM236 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex, Prefrontal Cortex, Skeletal Muscle and Whole Blood samples tested, there are no alleles within the gene TMEM236 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TMEM236' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1745 | Q40 | Are there any specific alleles within the gene SVIL associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Skeletal Muscle samples tested, there are no alleles within the gene SVIL that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SVIL' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.186 | Q40 | Are there any specific alleles within the gene RP11-342K6.4 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Caudate Basal Ganglia and Putamen Basal Ganglia samples tested, there are no alleles within the gene RP11-342K6.4 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-342K6.4' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.140 | Q40 | Are there any specific alleles within the gene FUT5 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Cortex samples tested, there are no alleles within the gene FUT5 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FUT5' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.907 | Q40 | Are there any specific alleles within the gene ZNF222 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene ZNF222 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF222' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.803 | Q40 | Are there any specific alleles within the gene RP11-1334A24.6 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-1334A24.6 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-1334A24.6' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.135 | Q40 | Are there any specific alleles within the gene SAP18 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood, Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Whole Brain samples tested, there are no alleles within the gene SAP18 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SAP18' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.83 | Q40 | Are there any specific alleles within the gene CCNE1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene CCNE1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CCNE1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1541 | Q40 | Are there any specific alleles within the gene OR2L5 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene OR2L5 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR2L5' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.547 | Q40 | Are there any specific alleles within the gene TRIM10 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene TRIM10 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs116187716
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.11e-06; b: 1.3123e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TRIM10' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620311', 'Gene': 'TRIM10', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs116187716', 'A1': 'A', 'A2': 'G', 'Freq': 0.104294, 'p_SMR_multi': 2.109493e-06, 'Disease': 'AD', 'b_SMR': 0.0131228, 'p_HEIDI': 0.4693696}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1596 | Q40 | Are there any specific alleles within the gene PMS2P1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene PMS2P1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs7384878
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.42e-15; b: 6.6801e-02
• rs2405442
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.21e-13; b: 7.7281e... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PMS2P1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_74053', 'Gene': 'PMS2P1', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs7384878', 'A1': 'T', 'A2': 'C', 'Freq': 0.675869, 'p_SMR_multi': 6.417134e-15, 'Disease': 'AD', 'b_SMR': 0.0668012, 'p_HEIDI': 1.79595e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_585989', 'Gene': 'PMS2P1', 'O... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.992 | Q40 | Are there any specific alleles within the gene XKR8 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene XKR8 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'XKR8' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.168 | Q40 | Are there any specific alleles within the gene GPR148 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene GPR148 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GPR148' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.251 | Q40 | Are there any specific alleles within the gene RBL2 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Whole Brain a... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RBL2' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.452 | Q40 | Are there any specific alleles within the gene RP11-65J21.3 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene RP11-65J21.3 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-65J21.3' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1148 | Q40 | Are there any specific alleles within the gene RP11-491F9.5 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex and Cerebellum samples tested, there are no alleles within the gene RP11-491F9.5 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-491F9.5' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.865 | Q40 | Are there any specific alleles within the gene CTD-2517O10.6 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested, there are no alleles within the gene CTD-2517O10.6 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTD-2517O10.6' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1233 | Q40 | Are there any specific alleles within the gene ZNF532 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene ZNF532 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF532' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.100 | Q40 | Are there any specific alleles within the gene GSDMD associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbe... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GSDMD' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1974 | Q40 | Are there any specific alleles within the gene CRHR1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 10 alleles within the gene CRHR1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs17689882
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.63e-15; b: 2.7361e-01
• rs112746008
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.74e-13; b: 3.87... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CRHR1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_948861', 'Gene': 'CRHR1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs17689882', 'A1': 'A', 'A2': 'G', 'Freq': 0.234151, 'p_SMR_multi': 8.633399e-15, 'Disease': 'PD', 'b_SMR': 0.273609, 'p_HEIDI': 7.397796e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_948860', 'Gene': 'CRHR1', 'O... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.744 | Q40 | Are there any specific alleles within the gene RN7SK associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene RN7SK that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RN7SK' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1252 | Q40 | Are there any specific alleles within the gene RP11-592B15.4 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene RP11-592B15.4 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-592B15.4' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.105 | Q40 | Are there any specific alleles within the gene MRPL35 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Hypothalamus, Whole Blood, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested, there are no alleles within the gene MRPL35 that are significantly associated with an incr... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MRPL35' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.440 | Q40 | Are there any specific alleles within the gene TBC1D28 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene TBC1D28 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TBC1D28' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.77 | Q40 | Are there any specific alleles within the gene AUTS2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene AUTS2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AUTS2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1793 | Q40 | Are there any specific alleles within the gene FCRLB associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Cerebellum, Hippocampus, Whole Brain, Whole Blood, Cortex, Liver and Nucleus Accumbens Basal samples tested, there are no alleles within the gene FCRLB that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FCRLB' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1462 | Q40 | Are there any specific alleles within the gene RP11-977B10.2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene RP11-977B10.2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-977B10.2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.926 | Q40 | Are there any specific alleles within the gene HSD3B7 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene HSD3B7 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs8060857
• Whole Brain: Adjusted SMR multi-SNP P-value: 8.00e-08; b: 2.1607e-01
• rs4889606
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.67e-07; b: 4.3491e... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HSD3B7' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_485447', 'Gene': 'HSD3B7', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs8060857', 'A1': 'G', 'A2': 'A', 'Freq': 0.361963, 'p_SMR_multi': 7.997804e-08, 'Disease': 'PD', 'b_SMR': 0.216066, 'p_HEIDI': 0.00668826}, {'UUID': 'NDD_SMR_genes_all_update_text_1563808', 'Gene': 'HSD3B7', 'O... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1712 | Q40 | Are there any specific alleles within the gene ASPRV1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene ASPRV1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ASPRV1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1671 | Q40 | Are there any specific alleles within the gene CDSN associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Cortex samples tested, there are no alleles within the gene CDSN that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CDSN' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1621 | Q40 | Are there any specific alleles within the gene RP11-378J18.3 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hypothalamus, Anterior Cingulate Cortex BA24, Amygdala and Nucleus Accumbens Basal samples tested, there are no alleles within the gene RP11-378J18.3 that ar... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-378J18.3' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.769 | Q40 | Are there any specific alleles within the gene TRAV22 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene TRAV22 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TRAV22' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.998 | Q40 | Are there any specific alleles within the gene C17orf49 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene C17orf49 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C17orf49' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.394 | Q40 | Are there any specific alleles within the gene ZNF646 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene ZNF646 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs750952
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.55e-06; b: 7.0724e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF646' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_577503', 'Gene': 'ZNF646', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs750952', 'A1': 'T', 'A2': 'C', 'Freq': 0.364008, 'p_SMR_multi': 2.551509e-06, 'Disease': 'AD', 'b_SMR': 0.0707243, 'p_HEIDI': 0.0004571813}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.238 | Q40 | Are there any specific alleles within the gene TRIAP1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene TRIAP1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TRIAP1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1508 | Q40 | Are there any specific alleles within the gene RELB associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene RELB that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs75654248
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.19e-10; b: 2.7803e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RELB' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637442', 'Gene': 'RELB', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs75654248', 'A1': 'G', 'A2': 'T', 'Freq': 0.0173824, 'p_SMR_multi': 3.188959e-10, 'Disease': 'AD', 'b_SMR': 0.278028, 'p_HEIDI': 0.0005592422}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.270 | Q40 | Are there any specific alleles within the gene HERC2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene HERC2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HERC2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1187 | Q40 | Are there any specific alleles within the gene CTD-2561B21.3 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene CTD-2561B21.3 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTD-2561B21.3' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.120 | Q40 | Are there any specific alleles within the gene PHYHIP associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Multi Ancestry Whole Brain and Cerebellum samples tested, there are no alleles within the gene PHYHIP that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PHYHIP' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1607 | Q40 | Are there any specific alleles within the gene FGFRL1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene FGFRL1 that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs74921869
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.86e-07; b: 2.0617e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FGFRL1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_996326', 'Gene': 'FGFRL1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs74921869', 'A1': 'A', 'A2': 'G', 'Freq': 0.199387, 'p_SMR_multi': 1.862031e-07, 'Disease': 'PD', 'b_SMR': 0.0206173, 'p_HEIDI': 1.496361e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.680 | Q40 | Are there any specific alleles within the gene MNF1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene MNF1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MNF1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.252 | Q40 | Are there any specific alleles within the gene RNU7-45P associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RNU7-45P that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RNU7-45P' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1958 | Q40 | Are there any specific alleles within the gene AP4M1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 4 alleles within the gene AP4M1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs999886
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.38e-12; b: 9.7779e-02
• rs6960432
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.38e-08; b: 1.0241e-0... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AP4M1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495792', 'Gene': 'AP4M1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs999886', 'A1': 'A', 'A2': 'G', 'Freq': 0.40184, 'p_SMR_multi': 3.380562e-12, 'Disease': 'AD', 'b_SMR': 0.0977794, 'p_HEIDI': 1.2004e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_585973', 'Gene': 'AP4M1', 'Omic... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1995 | Q40 | Are there any specific alleles within the gene TMBIM6 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Liver samples tested, there are no alleles within the gene TMBIM6 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TMBIM6' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.97 | Q40 | Are there any specific alleles within the gene RTCA associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested, there are no alleles within the gene RTCA that are significantly associated with an increased susceptibility to developing Lewy Body Demen... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RTCA' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.34 | Q40 | Are there any specific alleles within the gene AP000442.1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene AP000442.1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AP000442.1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1465 | Q40 | Are there any specific alleles within the gene CARD11 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene CARD11 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CARD11' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1668 | Q40 | Are there any specific alleles within the gene LINC00211 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene LINC00211 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LINC00211' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.454 | Q40 | Are there any specific alleles within the gene METTL27 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Hippocampus and Cortex samples tested, there are no alleles within the gene METTL27 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'METTL27' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.723 | Q40 | Are there any specific alleles within the gene C5orf34 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Anterior Cingulate Cortex BA24, Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene C5orf34 that are significantly associated with an increased susceptibility to de... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C5orf34' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1261 | Q40 | Are there any specific alleles within the gene OMD associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene OMD that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OMD' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1598 | Q40 | Are there any specific alleles within the gene SLC6A17 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene SLC6A17 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC6A17' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1 | Q40 | Are there any specific alleles within the gene MGC2889 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene MGC2889 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MGC2889' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1377 | Q40 | Are there any specific alleles within the gene MIR329-1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene MIR329-1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MIR329-1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1110 | Q40 | Are there any specific alleles within the gene NFYA associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 3 alleles within the gene NFYA that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs72856298
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.34e-10; b: 1.1186e-02
• rs62396353
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.60e-10; b: 1.0143e... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NFYA' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_622639', 'Gene': 'NFYA', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs72856298', 'A1': 'C', 'A2': 'T', 'Freq': 0.132924, 'p_SMR_multi': 3.336665e-10, 'Disease': 'AD', 'b_SMR': 0.0111859, 'p_HEIDI': 1.123977e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_622641', 'Gene': 'NFYA', 'Om... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1117 | Q40 | Are there any specific alleles within the gene PADI3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene PADI3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PADI3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1591 | Q40 | Are there any specific alleles within the gene LARP6 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Hippocampus, Multi Ancestry Whole Brain and Putamen Basal Ganglia samples tested, there are no alleles within the gene LARP6 that are significantly associated with an increased susceptibility to developing Lewy Body... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LARP6' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.85 | Q40 | Are there any specific alleles within the gene AC092620.3 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene AC092620.3 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AC092620.3' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1294 | Q40 | Are there any specific alleles within the gene ST6GAL1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene ST6GAL1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ST6GAL1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.683 | Q40 | Are there any specific alleles within the gene LRRC37A4P associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene LRRC37A4P that is significantly associated with an increased susceptibility to developing Progressive supranuclear palsy:
• rs11012
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.48e-39; b: 1.4369e+00 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LRRC37A4P' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1444269', 'Gene': 'LRRC37A4P', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs11012', 'A1': 'T', 'A2': 'C', 'Freq': 0.191207, 'p_SMR_multi': 4.478326e-39, 'Disease': 'PSP', 'b_SMR': 1.4369, 'p_HEIDI': 4.006733e-41}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1677 | Q40 | Are there any specific alleles within the gene CTC-429P9.2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene CTC-429P9.2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTC-429P9.2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
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