uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q40.1055 | Q40 | Are there any specific alleles within the gene ARL17B associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | Yes, there are 3 alleles within the gene ARL17B that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy:
• rs169201
• Cortex: Adjusted SMR multi-SNP P-value: 4.47e-42; b: 1.4509e+00
• Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.06e-13; b: 1.7210e+00
... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ARL17B' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1154399', 'Gene': 'ARL17B', 'Omic_tissue': 'Cortex', 'topSNP': '17:46712837:rs169201:A_G', 'A1': 'A', 'A2': 'G', 'Freq': 0.780164, 'p_SMR_multi': 4.4691469999999997e-42, 'Disease': 'PSP', 'b_SMR': 1.45093, 'p_HEIDI': 3.22368e-33}, {'UUID': 'NDD_SMR_genes_all_update_text_22219', ... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.777 | Q40 | Are there any specific alleles within the gene CTGF associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene CTGF that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTGF' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1289 | Q40 | Are there any specific alleles within the gene HSDL1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene HSDL1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HSDL1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1946 | Q40 | Are there any specific alleles within the gene NSFP1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene NSFP1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs17698176
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.33e-10; b: 6.1903e-02
• rs151267673
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 7.31e-07; b:... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NSFP1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1564791', 'Gene': 'NSFP1', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs17698176', 'A1': 'G', 'A2': 'T', 'Freq': 0.228016, 'p_SMR_multi': 9.333059e-10, 'Disease': 'PD', 'b_SMR': 0.0619032, 'p_HEIDI': 5.118198e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1242284', 'Gene': 'NSFP1',... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1581 | Q40 | Are there any specific alleles within the gene FAM227A associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested, there are no alleles w... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM227A' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1490 | Q40 | Are there any specific alleles within the gene ZC3H10 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene ZC3H10 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZC3H10' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.410 | Q40 | Are there any specific alleles within the gene CNPY4 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene CNPY4 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs7457787
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.33e-08; b: 6.6429e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CNPY4' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1392619', 'Gene': 'CNPY4', 'Omic_tissue': 'Multi Ancestry Whole Brain', 'topSNP': 'rs7457787', 'A1': 'C', 'A2': 'A', 'Freq': 0.132924, 'p_SMR_multi': 8.325836e-08, 'Disease': 'AD', 'b_SMR': 0.0664292, 'p_HEIDI': 4.508875e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1728 | Q40 | Are there any specific alleles within the gene RP11-120K18.3 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene RP11-120K18.3 that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs11150614
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.67e-07; b: 6.0167e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-120K18.3' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563821', 'Gene': 'RP11-120K18.3', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs11150614', 'A1': 'A', 'A2': 'G', 'Freq': 0.316973, 'p_SMR_multi': 3.669227e-07, 'Disease': 'PD', 'b_SMR': 0.0601668, 'p_HEIDI': 0.1276231}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1298 | Q40 | Are there any specific alleles within the gene STAG3L5P associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene STAG3L5P that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs6975660
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 5.47e-08; b: 6.2993e-03
• rs73401443
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-val... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'STAG3L5P' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1198851', 'Gene': 'STAG3L5P', 'Omic_tissue': 'Prefrontal Cortex', 'topSNP': 'rs6975660', 'A1': 'G', 'A2': 'A', 'Freq': 0.180982, 'p_SMR_multi': 5.468728e-08, 'Disease': 'AD', 'b_SMR': 0.00629933, 'p_HEIDI': 4.271835e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1392627', 'Gene':... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1665 | Q40 | Are there any specific alleles within the gene LETM1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood and Tibial Nerve samples tested, there are no alleles within the gene LETM1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LETM1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.107 | Q40 | Are there any specific alleles within the gene C2orf73 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Prefrontal Cortex samples tested, there are no alleles within the gene C2orf73 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C2orf73' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.695 | Q40 | Are there any specific alleles within the gene RP11-105C19.2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Whole Blood and Cerebellum samples tested, there are no alleles within the gene RP11-105C19.2 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-105C19.2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1305 | Q40 | Are there any specific alleles within the gene OR6C3 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene OR6C3 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR6C3' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.833 | Q40 | Are there any specific alleles within the gene SLC39A1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene SLC39A1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC39A1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.64 | Q40 | Are there any specific alleles within the gene RP11-98D18.9 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Whole Blood and Nucleus Accumbens Basal samples tested, there are no alleles within the gene RP11-98D18.9 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-98D18.9' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.859 | Q40 | Are there any specific alleles within the gene MMAB associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene MMAB that are significantly associated with an increased susceptibility to dev... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MMAB' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1355 | Q40 | Are there any specific alleles within the gene LOC100133545 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene LOC100133545 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LOC100133545' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.226 | Q40 | Are there any specific alleles within the gene TFR2 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Liver samples tested, there are no alleles within the gene TFR2 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TFR2' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.148 | Q40 | Are there any specific alleles within the gene NSF associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene NSF that is significantly associated with an increased susceptibility to developing Progressive supranuclear palsy:
• rs2074404
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.62e-21; b: 6.4434e+00 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NSF' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579432', 'Gene': 'NSF', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs2074404', 'A1': 'G', 'A2': 'T', 'Freq': 0.263804, 'p_SMR_multi': 1.6166329999999999e-21, 'Disease': 'PSP', 'b_SMR': 6.4434, 'p_HEIDI': 8.793892e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1097 | Q40 | Are there any specific alleles within the gene SLC35E4 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene SLC35E4 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC35E4' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.379 | Q40 | Are there any specific alleles within the gene CTB-171A8.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 3 alleles within the gene CTB-171A8.1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs79638902
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 4.04e-14; b: 9.5707e-02
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.69e-11; b: 7.3989... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTB-171A8.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203797', 'Gene': 'CTB-171A8.1', 'Omic_tissue': 'Prefrontal Cortex', 'topSNP': 'rs79638902', 'A1': 'T', 'A2': 'C', 'Freq': 0.146217, 'p_SMR_multi': 4.039964e-14, 'Disease': 'AD', 'b_SMR': 0.0957066, 'p_HEIDI': 1.189533e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1611533', 'Gen... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1422 | Q40 | Are there any specific alleles within the gene SLC35E1P1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Liver and Cerebellum samples tested, there are no alleles within the gene SLC35E1P1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC35E1P1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1152 | Q40 | Are there any specific alleles within the gene RP1-152L7.5 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus, Substantia nigra, Whole Blood and Cerebellum samples tested, there are no alleles within the gene RP1-152L7.5 that are significantly associated with an increased susceptibili... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP1-152L7.5' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1828 | Q40 | Are there any specific alleles within the gene HIST2H2BA associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested, there are no alleles within the gene HIST2H2BA that are signi... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HIST2H2BA' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1496 | Q40 | Are there any specific alleles within the gene SLC25A37 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene SLC25A37 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC25A37' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1602 | Q40 | Are there any specific alleles within the gene PM20D1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 3 alleles within the gene PM20D1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs9438393
• Cortex: Adjusted SMR multi-SNP P-value: 6.36e-07; b: 2.8054e-02
• rs823080
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.08e-07; b: 2.0235e-02
• ... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PM20D1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1142766', 'Gene': 'PM20D1', 'Omic_tissue': 'Cortex', 'topSNP': '1:205813590:rs9438393:A_G', 'A1': 'A', 'A2': 'G', 'Freq': 0.605317, 'p_SMR_multi': 6.359165e-07, 'Disease': 'PD', 'b_SMR': 0.0280542, 'p_HEIDI': 1.943967e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_944692', 'Gene'... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1759 | Q40 | Are there any specific alleles within the gene CHST4 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene CHST4 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CHST4' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.10 | Q40 | Are there any specific alleles within the gene MKL2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested, there are no alleles within the gene MKL2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'MKL2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.455 | Q40 | Are there any specific alleles within the gene WWTR1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene WWTR1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'WWTR1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.715 | Q40 | Are there any specific alleles within the gene OGFR-AS1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood and Liver samples tested, there are no alleles within the gene OGFR-AS1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OGFR-AS1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.258 | Q40 | Are there any specific alleles within the gene GDPD1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Multi Ancestry Whole Brain samples tested, there are no alleles within the gene GDPD1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'GDPD1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.889 | Q40 | Are there any specific alleles within the gene CHRNA2 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene CHRNA2 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs2472554
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.13e-07; b: 9.3418e-03 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CHRNA2' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_3683', 'Gene': 'CHRNA2', 'Omic_tissue': 'Cerebellum', 'topSNP': '8:27470837:rs2472554:G_C', 'A1': 'G', 'A2': 'C', 'Freq': 0.280164, 'p_SMR_multi': 1.132264e-07, 'Disease': 'AD', 'b_SMR': 0.00934178, 'p_HEIDI': 0.001579673}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.395 | Q40 | Are there any specific alleles within the gene TRIM40 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain and Whole Blood samples tested, there are no alleles within the gene TRIM40 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TRIM40' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.916 | Q40 | Are there any specific alleles within the gene RP11-1023L17.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene RP11-1023L17.1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-1023L17.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.932 | Q40 | Are there any specific alleles within the gene TNXB associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene TNXB that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs34214527
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.41e-08; b: 1.0707e-02
• rs17201588
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.06e-07; b: 1.6256e... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TNXB' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621344', 'Gene': 'TNXB', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs34214527', 'A1': 'T', 'A2': 'C', 'Freq': 0.095092, 'p_SMR_multi': 6.412823e-08, 'Disease': 'AD', 'b_SMR': 0.010707, 'p_HEIDI': 0.0002807721}, {'UUID': 'NDD_SMR_genes_all_update_text_621377', 'Gene': 'TNXB', 'Omi... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1704 | Q40 | Are there any specific alleles within the gene RNA5SP311 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene RNA5SP311 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RNA5SP311' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1231 | Q40 | Are there any specific alleles within the gene LINC00905 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene LINC00905 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LINC00905' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.466 | Q40 | Are there any specific alleles within the gene PHLDA2 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene PHLDA2 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PHLDA2' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1967 | Q40 | Are there any specific alleles within the gene C14orf1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene C14orf1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C14orf1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1178 | Q40 | Are there any specific alleles within the gene BLOC1S1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Skeletal Muscle, Multi Ancestry Whole Brain, Putamen Basal Ganglia, Whole Brain and Nucleus Accumbens Basal samples tested, there are no alleles within the gene BLOC1S1 that are significantly associated with an i... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'BLOC1S1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.967 | Q40 | Are there any specific alleles within the gene L47234.1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Prefrontal Cortex samples tested, there are no alleles within the gene L47234.1 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'L47234.1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.507 | Q40 | Are there any specific alleles within the gene ABL1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene ABL1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ABL1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.746 | Q40 | Are there any specific alleles within the gene ANKRD62 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cortex, Prefrontal Cortex and Whole Brain samples tested, there are no alleles within the gene ANKRD62 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ANKRD62' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1851 | Q40 | Are there any specific alleles within the gene FLJ36777 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene FLJ36777 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FLJ36777' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.875 | Q40 | Are there any specific alleles within the gene RP11-152F13.3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Liver, Whole Blood and Cerebellum samples tested, there are no alleles within the gene RP11-152F13.3 that are significantly associated with an increased susceptibility to... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-152F13.3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.738 | Q40 | Are there any specific alleles within the gene VASP associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene VASP that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs7252959
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.47e-07; b: 2.5076e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'VASP' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503927', 'Gene': 'VASP', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs7252959', 'A1': 'A', 'A2': 'G', 'Freq': 0.296524, 'p_SMR_multi': 4.468401e-07, 'Disease': 'AD', 'b_SMR': 0.0250761, 'p_HEIDI': 0.001260265}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.545 | Q40 | Are there any specific alleles within the gene DCD associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene DCD that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DCD' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1211 | Q40 | Are there any specific alleles within the gene ZMYND15 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene ZMYND15 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZMYND15' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.704 | Q40 | Are there any specific alleles within the gene RAB11FIP4 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene RAB11FIP4 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RAB11FIP4' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1394 | Q40 | Are there any specific alleles within the gene PYROXD2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Ba... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PYROXD2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1783 | Q40 | Are there any specific alleles within the gene CXCR4 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Skeletal Muscle and Whole Blood samples tested, there are no alleles within the gene CXCR4 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CXCR4' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1155 | Q40 | Are there any specific alleles within the gene CTB-113D17.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples ... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTB-113D17.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1040 | Q40 | Are there any specific alleles within the gene CTD-2571E19.3 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene CTD-2571E19.3 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CTD-2571E19.3' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.378 | Q40 | Are there any specific alleles within the gene TUBBP1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Tibial Nerve samples tested, there are no alleles within the gene TUBBP1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TUBBP1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.674 | Q40 | Are there any specific alleles within the gene RP11-360L9.4 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-360L9.4 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-360L9.4' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1527 | Q40 | Are there any specific alleles within the gene CASS4 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene CASS4 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs6014722
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.72e-09; b: 7.9104e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CASS4' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504670', 'Gene': 'CASS4', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs6014722', 'A1': 'A', 'A2': 'T', 'Freq': 0.0879346, 'p_SMR_multi': 9.717309e-09, 'Disease': 'AD', 'b_SMR': 0.791037, 'p_HEIDI': 0.03044452}, {'UUID': 'NDD_SMR_genes_all_update_text_1653496', 'Gene': 'CASS4', 'O... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.362 | Q40 | Are there any specific alleles within the gene PI4KAP2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested,... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PI4KAP2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.976 | Q40 | Are there any specific alleles within the gene PAXX associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum and Cortex samples tested, there are no alleles within the gene PAXX that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PAXX' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.790 | Q40 | Are there any specific alleles within the gene NEK11 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene NEK11 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NEK11' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.742 | Q40 | Are there any specific alleles within the gene RP11-474D1.2 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-474D1.2 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-474D1.2' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1044 | Q40 | Are there any specific alleles within the gene C4orf36 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood and Cortex samples tested, there are no alleles within the gene C4orf36 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C4orf36' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.979 | Q40 | Are there any specific alleles within the gene HMGB1P1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Caudate Basal Ganglia samples tested, there are no alleles within the gene HMGB1P1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HMGB1P1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1526 | Q40 | Are there any specific alleles within the gene VSTM2B associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood and Cerebellar Hemisphere samples tested, there are no alleles within the gene VSTM2B that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'VSTM2B' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1488 | Q40 | Are there any specific alleles within the gene PTP4A1 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene PTP4A1 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'PTP4A1' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1525 | Q40 | Are there any specific alleles within the gene A2MP1 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Whole Blood and Nucleus Accumbens Basal samples tested, there are no alleles within the gene A2MP1 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'A2MP1' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1492 | Q40 | Are there any specific alleles within the gene ZNF462 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex, Frontal Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Putamen Basal Ganglia and Whole Brain samples tested, there are no alleles within the gene ZNF462 that are significantly associated with an increased susceptibili... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF462' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1694 | Q40 | Are there any specific alleles within the gene QARS associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain samples tested, there are no alleles within the gene QARS that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'QARS' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1716 | Q40 | Are there any specific alleles within the gene TUBB8P7 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene TUBB8P7 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs112089506
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 6.61e-07; b: 1.1531e-01 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TUBB8P7' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1202665', 'Gene': 'TUBB8P7', 'Omic_tissue': 'Prefrontal Cortex', 'topSNP': 'rs112089506', 'A1': 'T', 'A2': 'C', 'Freq': 0.0858896, 'p_SMR_multi': 6.611364e-07, 'Disease': 'AD', 'b_SMR': 0.115312, 'p_HEIDI': 0.1987472}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1246 | Q40 | Are there any specific alleles within the gene NFKBIE associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested, there are no alleles within the gene NFKBIE that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'NFKBIE' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.892 | Q40 | Are there any specific alleles within the gene LRRK2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene LRRK2 that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs4363681
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.07e-07; b: 2.4581e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LRRK2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1561430', 'Gene': 'LRRK2', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs4363681', 'A1': 'T', 'A2': 'C', 'Freq': 0.448875, 'p_SMR_multi': 9.070753e-07, 'Disease': 'PD', 'b_SMR': 0.0245815, 'p_HEIDI': 1.978415e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.82 | Q40 | Are there any specific alleles within the gene RP11-141J13.3 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene RP11-141J13.3 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-141J13.3' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1182 | Q40 | Are there any specific alleles within the gene INSYN2A associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cortex samples tested, there are no alleles within the gene INSYN2A that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'INSYN2A' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.821 | Q40 | Are there any specific alleles within the gene C7orf59 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 2 alleles within the gene C7orf59 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs11771139
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.98e-13; b: 5.7578e-02
• rs60458236
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.31e-09; b: 3.74... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'C7orf59' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_585977', 'Gene': 'C7orf59', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs11771139', 'A1': 'A', 'A2': 'G', 'Freq': 0.271984, 'p_SMR_multi': 3.977226e-13, 'Disease': 'AD', 'b_SMR': 0.0575781, 'p_HEIDI': 8.913888e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_74040', 'Gene': 'C7orf59'... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1283 | Q40 | Are there any specific alleles within the gene RP1-71H24.1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Caudate Basal Ganglia, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested, there are no alleles within the gene RP1-71H24.1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP1-71H24.1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.678 | Q40 | Are there any specific alleles within the gene ZSWIM7 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there are 3 alleles within the gene ZSWIM7 that are significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs1860643
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.55e-07; b: 9.8383e-02
• rs2535614
• Cortex: Adjusted SMR multi-SNP P-value: 2.31e-06; b: 1.1837e-01
•... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZSWIM7' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1640053', 'Gene': 'ZSWIM7', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs1860643', 'A1': 'T', 'A2': 'C', 'Freq': 0.42229, 'p_SMR_multi': 6.546399e-07, 'Disease': 'PD', 'b_SMR': 0.0983835, 'p_HEIDI': 0.2378725}, {'UUID': 'NDD_SMR_genes_all_update_text_1147084', 'Gene': 'ZSWIM7', 'O... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1533 | Q40 | Are there any specific alleles within the gene RP11-1260E13.2 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Liver samples tested, there are no alleles within the gene RP11-1260E13.2 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-1260E13.2' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.59 | Q40 | Are there any specific alleles within the gene POLR2L associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene POLR2L that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'POLR2L' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.136 | Q40 | Are there any specific alleles within the gene ALOX15P2 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene ALOX15P2 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ALOX15P2' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1150 | Q40 | Are there any specific alleles within the gene RP11-666A8.9 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Tibial Nerve, Skeletal Muscle and Whole Blood samples tested, there are no alleles within the gene RP11-666A8.9 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-666A8.9' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.942 | Q40 | Are there any specific alleles within the gene ZNF311 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene ZNF311 that is significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs142403264
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.47e-07; b: 4.7304e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZNF311' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_619798', 'Gene': 'ZNF311', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs142403264', 'A1': 'C', 'A2': 'T', 'Freq': 0.517382, 'p_SMR_multi': 2.474527e-07, 'Disease': 'AD', 'b_SMR': 0.0473044, 'p_HEIDI': 0.1408498}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1685 | Q40 | Are there any specific alleles within the gene TSPAN14 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 4 alleles within the gene TSPAN14 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs7086627
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.79e-08; b: 8.0927e-02
• rs10749609
• Cortex: Adjusted SMR multi-SNP P-value: 1.59e-07; b: 1.9052e-01... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TSPAN14' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_85783', 'Gene': 'TSPAN14', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs7086627', 'A1': 'T', 'A2': 'C', 'Freq': 0.747444, 'p_SMR_multi': 2.786675e-08, 'Disease': 'AD', 'b_SMR': 0.0809267, 'p_HEIDI': 0.001397175}, {'UUID': 'NDD_SMR_genes_all_update_text_1105563', 'Gene': 'TSPAN14',... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.830 | Q40 | Are there any specific alleles within the gene CD1B associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene CD1B that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'CD1B' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1224 | Q40 | Are there any specific alleles within the gene LRIG1 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Hypothalamus samples tested, there are no alleles within the gene LRIG1 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'LRIG1' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.510 | Q40 | Are there any specific alleles within the gene POGLUT1 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Liver, Whole Blood, Putamen Basal Ganglia, Whole Brain and Nucleus Accumbens Basal samples tested, there are no alle... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'POGLUT1' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1776 | Q40 | Are there any specific alleles within the gene DES associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene DES that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DES' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.351 | Q40 | Are there any specific alleles within the gene AP002954.4 associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene AP002954.4 that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'AP002954.4' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.392 | Q40 | Are there any specific alleles within the gene ZRANB1 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested, there are no alleles within the gene ZRANB1 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ZRANB1' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1033 | Q40 | Are there any specific alleles within the gene DOT1L associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Caudate Basal Ganglia, Multi Ancestry Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested, there are no alleles within the gene DOT1L that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'DOT1L' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.901 | Q40 | Are there any specific alleles within the gene SLC52A1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Cortex samples tested, there are no alleles within the gene SLC52A1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SLC52A1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.835 | Q40 | Are there any specific alleles within the gene RP11-433P17.3 associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Tibial Nerve samples tested, there are no alleles within the gene RP11-433P17.3 that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-433P17.3' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1894 | Q40 | Are there any specific alleles within the gene FAM57B associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | Yes, there are 4 alleles within the gene FAM57B that are significantly associated with an increased susceptibility to developing Alzheimer's Disease:
• rs11642399
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.64e-08; b: 8.5481e-02
• rs4788213
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.65e-07; b: 9.1714... | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'FAM57B' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_577429', 'Gene': 'FAM57B', 'Omic_tissue': 'Whole Blood', 'topSNP': 'rs11642399', 'A1': 'G', 'A2': 'T', 'Freq': 0.465235, 'p_SMR_multi': 2.638529e-08, 'Disease': 'AD', 'b_SMR': 0.0854811, 'p_HEIDI': 0.06960655}, {'UUID': 'NDD_SMR_genes_all_update_text_109463', 'Gene': 'FAM57B', '... | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.481 | Q40 | Are there any specific alleles within the gene OR2L3 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Cerebellum, Basal Ganglia, Hippocampus, Cortex, Cerebellar Hemisphere and Prefrontal Cortex samples tested, there are no alleles within the gene OR2L3 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR2L3' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1472 | Q40 | Are there any specific alleles within the gene SIPA1 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene SIPA1 that are significantly associated with an increased susceptibility to developing Parkinson's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'SIPA1' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1887 | Q40 | Are there any specific alleles within the gene RP4-583P15.15 associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested, there are no alleles within the gene RP4-583P15.15 that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP4-583P15.15' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1398 | Q40 | Are there any specific alleles within the gene RP11-1029J19.4 associated with increased susceptibility to developing Frontotemporal Dementia, as determined by significant SMR analysis? | No, based on the Whole Blood samples tested, there are no alleles within the gene RP11-1029J19.4 that are significantly associated with an increased susceptibility to developing Frontotemporal Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RP11-1029J19.4' AND Disease = 'FTD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.659 | Q40 | Are there any specific alleles within the gene TET3 associated with increased susceptibility to developing Progressive supranuclear palsy, as determined by significant SMR analysis? | No, based on the Whole Brain and Whole Blood samples tested, there are no alleles within the gene TET3 that are significantly associated with an increased susceptibility to developing Progressive supranuclear palsy. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'TET3' AND Disease = 'PSP' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.175 | Q40 | Are there any specific alleles within the gene ELOVL7 associated with increased susceptibility to developing Parkinson's Disease, as determined by significant SMR analysis? | Yes, there is 1 allele within the gene ELOVL7 that is significantly associated with an increased susceptibility to developing Parkinson's Disease:
• rs34741733
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.23e-07; b: 8.0660e-02 | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'ELOVL7' AND Disease = 'PD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_435605', 'Gene': 'ELOVL7', 'Omic_tissue': 'Whole Brain', 'topSNP': 'rs34741733', 'A1': 'T', 'A2': 'C', 'Freq': 0.400818, 'p_SMR_multi': 3.228168e-07, 'Disease': 'PD', 'b_SMR': 0.0806597, 'p_HEIDI': 1.693944e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.1159 | Q40 | Are there any specific alleles within the gene OR2I1P associated with increased susceptibility to developing Amyotrophic Lateral Sclerosis, as determined by significant SMR analysis? | No, based on the Whole Brain, Whole Blood, Cortex and Liver samples tested, there are no alleles within the gene OR2I1P that are significantly associated with an increased susceptibility to developing Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'OR2I1P' AND Disease = 'ALS' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.39 | Q40 | Are there any specific alleles within the gene RFLNB associated with increased susceptibility to developing Lewy Body Dementia, as determined by significant SMR analysis? | No, based on the Cerebellum, Hippocampus and Cortex samples tested, there are no alleles within the gene RFLNB that are significantly associated with an increased susceptibility to developing Lewy Body Dementia. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'RFLNB' AND Disease = 'LBD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
Q40.720 | Q40 | Are there any specific alleles within the gene HHAT associated with increased susceptibility to developing Alzheimer's Disease, as determined by significant SMR analysis? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested, there are no alleles within the gene HHAT that are significantly associated with an increased susceptibility to developing Alzheimer's Disease. | SELECT UUID, Gene, Omic_tissue, topSNP, A1, A2, Freq, p_SMR_multi, Disease, b_SMR, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Gene = 'HHAT' AND Disease = 'AD' AND p_SMR_multi < 2.95e-6 AND b_SMR > 0
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance, Effect |
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