uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q55.1361 | Q55 | Based on Hypothalamus eQTL data, what is the top SNP in RP11-707O23.5 that is associated with Parkinson's Disease (PD), and what is its adjusted SMR p-value? | RP11-707O23.5's most significantly associated SNP with Parkinson's Disease in the Hypothalamus eQTL is rs55974014, with adjusted SMR multi-SNP P-value of 1.27e-11 and a HEIDI value of 8.5301e-01. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-707O23.5' AND LOWER(Omic_type) LIKE "%hypothalamus eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_mul... | [{'UUID': 'NDD_SMR_genes_all_update_text_1462891', 'topRSID': 'rs55974014', 'Disease': 'PD', 'Gene': 'RP11-707O23.5', 'p_SMR_multi': 1.274776e-11, 'p_HEIDI': 0.8530115, 'Omic_tissue': 'Hypothalamus', 'Omic_type': 'Hypothalamus eQTL'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1291 | Q55 | Based on Caudate Basal Ganglia eQTL data, what is the top SNP in INPP5D that is associated with Amyotrophic Lateral Sclerosis, and what is its adjusted SMR p-value? | INPP5D has no SNPs significantly associated with Amyotrophic Lateral Sclerosis in the Caudate Basal Ganglia eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'INPP5D' AND LOWER(Omic_type) LIKE "%caudate basal ganglia eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1969 | Q55 | Based on Nucleus Accumbens Basal Ganglia data, what is the top SNP in POLR2E that is associated with Parkinson's Disease, and what is its adjusted SMR p-value? | POLR2E has no SNPs significantly associated with Parkinson's Disease in the Nucleus Accumbens Basal Ganglia. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'POLR2E' AND LOWER(Omic_type) LIKE "%nucleus accumbens basal ganglia%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.935 | Q55 | Based on Skeletal Muscle eQTL data, what is the top SNP in CCNE2 that is associated with Parkinson's Disease, and what is its adjusted SMR p-value? | CCNE2 has no SNPs significantly associated with Parkinson's Disease in the Skeletal Muscle eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CCNE2' AND LOWER(Omic_type) LIKE "%skeletal muscle eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
L... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.989 | Q55 | Based on Prefrontal Cortex eQTL data, what is the top SNP in SFTA2 that is associated with Alzheimer's Disease, and what is its adjusted SMR p-value? | SFTA2 has no SNPs significantly associated with Alzheimer's Disease in the Prefrontal Cortex eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SFTA2' AND LOWER(Omic_type) LIKE "%prefrontal cortex eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1965 | Q55 | Based on Whole Brain meta-analysis mQTL data, what is the top SNP in REXO1 that is associated with Alzheimer's Disease (AD), and what is its adjusted SMR p-value? | REXO1's most significantly associated SNP with Alzheimer's Disease in the Whole Brain meta-analysis mQTL is rs12976128, with adjusted SMR multi-SNP P-value of 1.23e-06 and a HEIDI value of 1.0811e-02. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'REXO1' AND LOWER(Omic_type) LIKE "%whole brain meta-analysis mqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SM... | [{'UUID': 'NDD_SMR_genes_all_update_text_119552', 'topRSID': 'rs12976128', 'Disease': 'AD', 'Gene': 'REXO1', 'p_SMR_multi': 1.225713e-06, 'p_HEIDI': 0.01081071, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain meta-analysis mQTL'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.193 | Q55 | Based on Substantia nigra eQTL data, what is the top SNP in RAB8B that is associated with Amyotrophic Lateral Sclerosis, and what is its adjusted SMR p-value? | RAB8B has no SNPs significantly associated with Amyotrophic Lateral Sclerosis in the Substantia nigra eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RAB8B' AND LOWER(Omic_type) LIKE "%substantia nigra eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1149 | Q55 | Based on Whole Blood eQTL eQTLgen data, what is the top SNP in GATS that is associated with Amyotrophic Lateral Sclerosis, and what is its adjusted SMR p-value? | GATS has no SNPs significantly associated with Amyotrophic Lateral Sclerosis in the Whole Blood eQTL eQTLgen. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'GATS' AND LOWER(Omic_type) LIKE "%whole blood eqtl eqtlgen%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_mult... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1001 | Q55 | Based on Cerebellar Hemisphere eQTL data, what is the top SNP in EPHA1 that is associated with Amyotrophic Lateral Sclerosis, and what is its adjusted SMR p-value? | EPHA1 has no SNPs significantly associated with Amyotrophic Lateral Sclerosis in the Cerebellar Hemisphere eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'EPHA1' AND LOWER(Omic_type) LIKE "%cerebellar hemisphere eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_m... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1956 | Q55 | Based on Prefrontal Cortex eQTL data, what is the top SNP in GATS that is associated with Parkinson's Disease, and what is its adjusted SMR p-value? | GATS has no SNPs significantly associated with Parkinson's Disease in the Prefrontal Cortex eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GATS' AND LOWER(Omic_type) LIKE "%prefrontal cortex eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1657 | Q55 | Based on Liver eQTL data, what is the top SNP in APOC4 that is associated with Alzheimer's Disease (AD), and what is its adjusted SMR p-value? | APOC4's most significantly associated SNP with Alzheimer's Disease in the Liver eQTL is rs73045691, with adjusted SMR multi-SNP P-value of 3.17e-11 and a HEIDI value of 4.6883e-01. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'APOC4' AND LOWER(Omic_type) LIKE "%liver eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LIMIT 1 | [{'UUID': 'NDD_SMR_genes_all_update_text_1466879', 'topRSID': 'rs73045691', 'Disease': 'AD', 'Gene': 'APOC4', 'p_SMR_multi': 3.171686e-11, 'p_HEIDI': 0.4688313, 'Omic_tissue': 'Liver', 'Omic_type': 'Liver eQTL'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.613 | Q55 | Based on Whole Brain eQTL data, what is the top SNP in C16orf93 that is associated with Parkinson's Disease (PD), and what is its adjusted SMR p-value? | C16orf93's most significantly associated SNP with Parkinson's Disease in the Whole Brain eQTL is rs885107, with adjusted SMR multi-SNP P-value of 1.69e-07 and a HEIDI value of 1.8775e-01. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'C16orf93' AND LOWER(Omic_type) LIKE "%whole brain eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LI... | [{'UUID': 'NDD_SMR_genes_all_update_text_1639759', 'topRSID': 'rs885107', 'Disease': 'PD', 'Gene': 'C16orf93', 'p_SMR_multi': 1.689818e-07, 'p_HEIDI': 0.1877494, 'Omic_tissue': 'Whole Brain', 'Omic_type': 'Whole Brain eQTL'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.183 | Q55 | Based on Amygdala eQTL data, what is the top SNP in ZNF646 that is associated with Amyotrophic Lateral Sclerosis, and what is its adjusted SMR p-value? | ZNF646 has no SNPs significantly associated with Amyotrophic Lateral Sclerosis in the Amygdala eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ZNF646' AND LOWER(Omic_type) LIKE "%amygdala eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LIMIT ... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.305 | Q55 | Based on Whole Brain eQTL data, what is the top SNP in DCAKD that is associated with Lewy Body Dementia, and what is its adjusted SMR p-value? | DCAKD has no SNPs significantly associated with Lewy Body Dementia in the Whole Brain eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'DCAKD' AND LOWER(Omic_type) LIKE "%whole brain eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LIMI... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.502 | Q55 | Based on Hippocampus eQTL data, what is the top SNP in KLHL7-AS1 that is associated with Parkinson's Disease (PD), and what is its adjusted SMR p-value? | KLHL7-AS1's most significantly associated SNP with Parkinson's Disease in the Hippocampus eQTL is rs6978827, with adjusted SMR multi-SNP P-value of 5.03e-07 and a HEIDI value of 1.5816e-02. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KLHL7-AS1' AND LOWER(Omic_type) LIKE "%hippocampus eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
L... | [{'UUID': 'NDD_SMR_genes_all_update_text_1386053', 'topRSID': 'rs6978827', 'Disease': 'PD', 'Gene': 'KLHL7-AS1', 'p_SMR_multi': 5.026324e-07, 'p_HEIDI': 0.01581612, 'Omic_tissue': 'Hippocampus', 'Omic_type': 'Hippocampus eQTL'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1696 | Q55 | Based on Whole Blood eQTL GTEx data, what is the top SNP in ZNF668 that is associated with Parkinson's Disease (PD), and what is its adjusted SMR p-value? | ZNF668's most significantly associated SNP with Parkinson's Disease in the Whole Blood eQTL GTEx is rs4889530, with adjusted SMR multi-SNP P-value of 1.74e-07 and a HEIDI value of 1.1136e-02. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZNF668' AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
... | [{'UUID': 'NDD_SMR_genes_all_update_text_1679160', 'topRSID': 'rs4889530', 'Disease': 'PD', 'Gene': 'ZNF668', 'p_SMR_multi': 1.736465e-07, 'p_HEIDI': 0.01113564, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL GTEx'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1721 | Q55 | Based on Putamen Basal Ganglia eQTL data, what is the top SNP in FNBP4 that is associated with Progressive supranuclear palsy, and what is its adjusted SMR p-value? | FNBP4 has no SNPs significantly associated with Progressive supranuclear palsy in the Putamen Basal Ganglia eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FNBP4' AND LOWER(Omic_type) LIKE "%putamen basal ganglia eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_m... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1662 | Q55 | Based on Whole Blood eQTL GTEx data, what is the top SNP in RP11-707O23.5 that is associated with Alzheimer's Disease (AD), and what is its adjusted SMR p-value? | RP11-707O23.5's most significantly associated SNP with Alzheimer's Disease in the Whole Blood eQTL GTEx is rs55974014, with adjusted SMR multi-SNP P-value of 1.54e-06 and a HEIDI value of 6.6050e-01. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-707O23.5' AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR... | [{'UUID': 'NDD_SMR_genes_all_update_text_1652496', 'topRSID': 'rs55974014', 'Disease': 'AD', 'Gene': 'RP11-707O23.5', 'p_SMR_multi': 1.540988e-06, 'p_HEIDI': 0.6604964, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL GTEx'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1639 | Q55 | Based on Whole Blood eQTL GTEx data, what is the top SNP in LRRC37A that is associated with Alzheimer's Disease (AD), and what is its adjusted SMR p-value? | LRRC37A's most significantly associated SNP with Alzheimer's Disease in the Whole Blood eQTL GTEx is rs4510068, with adjusted SMR multi-SNP P-value of 1.61e-06 and a HEIDI value of 8.1075e-02. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LRRC37A' AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi... | [{'UUID': 'NDD_SMR_genes_all_update_text_1652503', 'topRSID': 'rs4510068', 'Disease': 'AD', 'Gene': 'LRRC37A', 'p_SMR_multi': 1.613978e-06, 'p_HEIDI': 0.08107542, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood eQTL GTEx'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.523 | Q55 | Based on Cortex eQTL metaBrain data, what is the top SNP in AP001257.1 that is associated with Progressive supranuclear palsy, and what is its adjusted SMR p-value? | AP001257.1 has no SNPs significantly associated with Progressive supranuclear palsy in the Cortex eQTL metaBrain. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AP001257.1' AND LOWER(Omic_type) LIKE "%cortex eqtl metabrain%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_m... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1985 | Q55 | Based on Whole Brain eQTL data, what is the top SNP in GATS that is associated with Progressive supranuclear palsy, and what is its adjusted SMR p-value? | GATS has no SNPs significantly associated with Progressive supranuclear palsy in the Whole Brain eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'GATS' AND LOWER(Omic_type) LIKE "%whole brain eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LIMIT... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1078 | Q55 | Based on Substantia nigra eQTL data, what is the top SNP in TMEM175 that is associated with Lewy Body Dementia, and what is its adjusted SMR p-value? | TMEM175 has no SNPs significantly associated with Lewy Body Dementia in the Substantia nigra eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TMEM175' AND LOWER(Omic_type) LIKE "%substantia nigra eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_mult... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.482 | Q55 | Based on Caudate Basal Ganglia eQTL data, what is the top SNP in LRRC37A that is associated with Parkinson's Disease, and what is its adjusted SMR p-value? | LRRC37A has no SNPs significantly associated with Parkinson's Disease in the Caudate Basal Ganglia eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LRRC37A' AND LOWER(Omic_type) LIKE "%caudate basal ganglia eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.160 | Q55 | Based on Amygdala eQTL data, what is the top SNP in BTNL2 that is associated with Alzheimer's Disease, and what is its adjusted SMR p-value? | BTNL2 has no SNPs significantly associated with Alzheimer's Disease in the Amygdala eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'BTNL2' AND LOWER(Omic_type) LIKE "%amygdala eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LIMIT 1 | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1253 | Q55 | Based on Tibial Nerve eQTL data, what is the top SNP in RP11-707O23.5 that is associated with Progressive supranuclear palsy, and what is its adjusted SMR p-value? | RP11-707O23.5 has no SNPs significantly associated with Progressive supranuclear palsy in the Tibial Nerve eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-707O23.5' AND LOWER(Omic_type) LIKE "%tibial nerve eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_mu... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1205 | Q55 | Based on Frontal Cortex BA9 eQTL data, what is the top SNP in RP11-259G18.2 that is associated with Parkinson's Disease (PD), and what is its adjusted SMR p-value? | RP11-259G18.2's most significantly associated SNP with Parkinson's Disease in the Frontal Cortex BA9 eQTL is rs55974014, with adjusted SMR multi-SNP P-value of 5.84e-11 and a HEIDI value of 3.2943e-01. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-259G18.2' AND LOWER(Omic_type) LIKE "%frontal cortex ba9 eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_S... | [{'UUID': 'NDD_SMR_genes_all_update_text_1168836', 'topRSID': 'rs55974014', 'Disease': 'PD', 'Gene': 'RP11-259G18.2', 'p_SMR_multi': 5.837979e-11, 'p_HEIDI': 0.3294297, 'Omic_tissue': 'Frontal Cortex', 'Omic_type': 'Frontal Cortex BA9 eQTL'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.17 | Q55 | Based on Cerebellum eQTL data, what is the top SNP in TRIM31 that is associated with Progressive supranuclear palsy, and what is its adjusted SMR p-value? | TRIM31 has no SNPs significantly associated with Progressive supranuclear palsy in the Cerebellum eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'TRIM31' AND LOWER(Omic_type) LIKE "%cerebellum eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LIMI... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1550 | Q55 | Based on Whole Blood eQTL GTEx data, what is the top SNP in SNCA that is associated with Parkinson's Disease, and what is its adjusted SMR p-value? | SNCA has no SNPs significantly associated with Parkinson's Disease in the Whole Blood eQTL GTEx. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SNCA' AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
L... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1081 | Q55 | Based on Whole Blood eQTL GTEx data, what is the top SNP in RP11-137H2.4 that is associated with Alzheimer's Disease, and what is its adjusted SMR p-value? | RP11-137H2.4 has no SNPs significantly associated with Alzheimer's Disease in the Whole Blood eQTL GTEx. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-137H2.4' AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1972 | Q55 | Based on Cortex eQTL GTEx data, what is the top SNP in STK39 that is associated with Amyotrophic Lateral Sclerosis, and what is its adjusted SMR p-value? | STK39 has no SNPs significantly associated with Amyotrophic Lateral Sclerosis in the Cortex eQTL GTEx. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'STK39' AND LOWER(Omic_type) LIKE "%cortex eqtl gtex%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LIMI... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.552 | Q55 | Based on Substantia nigra eQTL data, what is the top SNP in RP11-455F5.3 that is associated with Amyotrophic Lateral Sclerosis, and what is its adjusted SMR p-value? | RP11-455F5.3 has no SNPs significantly associated with Amyotrophic Lateral Sclerosis in the Substantia nigra eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-455F5.3' AND LOWER(Omic_type) LIKE "%substantia nigra eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1554 | Q55 | Based on Hypothalamus eQTL data, what is the top SNP in RP11-448P19.1 that is associated with Amyotrophic Lateral Sclerosis, and what is its adjusted SMR p-value? | RP11-448P19.1 has no SNPs significantly associated with Amyotrophic Lateral Sclerosis in the Hypothalamus eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-448P19.1' AND LOWER(Omic_type) LIKE "%hypothalamus eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_mu... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.665 | Q55 | Based on Amygdala eQTL data, what is the top SNP in RP11-196G11.4 that is associated with Progressive supranuclear palsy, and what is its adjusted SMR p-value? | RP11-196G11.4 has no SNPs significantly associated with Progressive supranuclear palsy in the Amygdala eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-196G11.4' AND LOWER(Omic_type) LIKE "%amygdala eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1626 | Q55 | Based on Cortex eQTL metaBrain data, what is the top SNP in FAM215B that is associated with Progressive supranuclear palsy, and what is its adjusted SMR p-value? | FAM215B has no SNPs significantly associated with Progressive supranuclear palsy in the Cortex eQTL metaBrain. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FAM215B' AND LOWER(Omic_type) LIKE "%cortex eqtl metabrain%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_mult... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1028 | Q55 | Based on Basal Ganglia eQTL data, what is the top SNP in CTD-2020K17.1 that is associated with Progressive supranuclear palsy, and what is its adjusted SMR p-value? | CTD-2020K17.1 has no SNPs significantly associated with Progressive supranuclear palsy in the Basal Ganglia eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTD-2020K17.1' AND LOWER(Omic_type) LIKE "%basal ganglia eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_m... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1994 | Q55 | Based on Skeletal Muscle eQTL data, what is the top SNP in GATS that is associated with Alzheimer's Disease (AD), and what is its adjusted SMR p-value? | GATS's most significantly associated SNP with Alzheimer's Disease in the Skeletal Muscle eQTL is rs1727133, with adjusted SMR multi-SNP P-value of 6.13e-07 and a HEIDI value of 2.1806e-01. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GATS' AND LOWER(Omic_type) LIKE "%skeletal muscle eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LI... | [{'UUID': 'NDD_SMR_genes_all_update_text_1340318', 'topRSID': 'rs1727133', 'Disease': 'AD', 'Gene': 'GATS', 'p_SMR_multi': 6.128731e-07, 'p_HEIDI': 0.2180583, 'Omic_tissue': 'Skeletal Muscle', 'Omic_type': 'Skeletal Muscle eQTL'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1519 | Q55 | Based on Whole Blood eQTL GTEx data, what is the top SNP in ADORA2B that is associated with Lewy Body Dementia, and what is its adjusted SMR p-value? | ADORA2B has no SNPs significantly associated with Lewy Body Dementia in the Whole Blood eQTL GTEx. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ADORA2B' AND LOWER(Omic_type) LIKE "%whole blood eqtl gtex%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_mult... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.968 | Q55 | Based on Whole Blood mQTL data, what is the top SNP in SPI1 that is associated with Alzheimer's Disease (AD), and what is its adjusted SMR p-value? | SPI1's most significantly associated SNP with Alzheimer's Disease in the Whole Blood mQTL is rs12801188, with adjusted SMR multi-SNP P-value of 2.27e-06 and a HEIDI value of 5.0728e-02. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SPI1' AND LOWER(Omic_type) LIKE "%whole blood mqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_multi
LIMIT ... | [{'UUID': 'NDD_SMR_genes_all_update_text_608486', 'topRSID': 'rs12801188', 'Disease': 'AD', 'Gene': 'SPI1', 'p_SMR_multi': 2.26569e-06, 'p_HEIDI': 0.05072849, 'Omic_tissue': 'Whole Blood', 'Omic_type': 'Whole Blood mQTL'}] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.1883 | Q55 | Based on Frontal Cortex BA9 eQTL data, what is the top SNP in PMS2P1 that is associated with Progressive supranuclear palsy, and what is its adjusted SMR p-value? | PMS2P1 has no SNPs significantly associated with Progressive supranuclear palsy in the Frontal Cortex BA9 eQTL. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'PMS2P1' AND LOWER(Omic_type) LIKE "%frontal cortex ba9 eqtl%" AND p_SMR_multi < 2.95e-6 AND p_HEIDI > 0.01
ORDER BY p_SMR_mul... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q55.287 | Q55 | Based on Anterior Cingulate Cortex BA24 eQTL data, what is the top SNP in PLEKHM1 that is associated with Progressive supranuclear palsy (PSP), and what is its adjusted SMR p-value? | PLEKHM1's most significantly associated SNP with Progressive supranuclear palsy in the Anterior Cingulate Cortex BA24 eQTL is rs11012, with adjusted SMR multi-SNP P-value of 8.50e-08 and a HEIDI value of 4.8750e-01. | SELECT UUID, topRSID, Disease, Gene, p_SMR_multi, p_HEIDI, Omic_tissue, Omic_type
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'Progressive supranuclear palsy (PSP)' AND Gene = 'PLEKHM1' AND LOWER(Omic_type) LIKE "%anterior cingulate cortex ba24 eqtl%" AND p_SMR_multi < ... | [] | refined | Select, Multi-Filter, Similarity Search, Order By, Threshold | Functional Significance |
Q58.589 | Q58 | How many genes does the drug Infigratinib target and what are they? | There are 4 gene targets for the drug Infigratinib: FGFR3, FGFR1, FGFR4, and FGFR2. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%infigratinib%" OR LOWER(tradeNames_string) LIKE ... | [{'UUID': 'DrugGeneTargets_v2_1239', 'drugName': 'Infigratinib', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG00000066468)', 'numberLinkedTargets': 4, 'yearOfFirstApproval': 2021, 'maxClinicalTrialPhase': 4, 'dru... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1868 | Q58 | How many genes does the drug Inamrinone Lactate target and what are they? | PDE3A is the only gene target of drug Inamrinone Lactate. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%inamrinone lactate%" OR LOWER(tradeNames_string)... | [{'UUID': 'DrugGeneTargets_v2_4359', 'drugName': 'Inamrinone Lactate', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'PDE3A (ENSG00000172572)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1984, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1061 | Q58 | How many genes does the drug Orantinib target and what are they? | The drug Orantinib is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 7 genes: FGFR3, FGFR1, FGFR4, FGFR2, KDR, PDGFRB, and PDGFRA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%orantinib%" OR LOWER(tradeNames_string) LIKE "%o... | [{'UUID': 'DrugGeneTargets_v2_1789', 'drugName': 'Orantinib', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG00000066468), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853)', 'numberLinkedTa... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1084 | Q58 | How many genes does the drug Amitriptyline target and what are they? | There are 2 gene targets for the drug Amitriptyline: SLC6A2 and SLC6A4. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%amitriptyline%" OR LOWER(tradeNames_string) LIKE... | [{'UUID': 'DrugGeneTargets_v2_598', 'drugName': 'Nortriptyline', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'SLC6A4 (ENSG00000108576), SLC6A2 (ENSG00000103546)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 1964, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.925 | Q58 | How many genes does the drug Febuxostat target and what are they? | XDH is the only gene target of drug Febuxostat. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%febuxostat%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_1230', 'drugName': 'Febuxostat', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'XDH (ENSG00000158125)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2009, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.73 | Q58 | How many genes does the drug Daunorubicin target and what are they? | TOP2A is the only gene target of drug Daunorubicin. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%daunorubicin%" OR LOWER(tradeNames_string) LIKE ... | [{'UUID': 'DrugGeneTargets_v2_1919', 'drugName': 'Daunorubicin Hydrochloride', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'TOP2A (ENSG00000131747)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1979, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_484', 'drug... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.435 | Q58 | How many genes does the drug Rwj-67657 target and what are they? | The drug Rwj-67657 is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 2 genes: MAPK11 and MAPK14. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%rwj-67657%" OR LOWER(tradeNames_string) LIKE "%r... | [{'UUID': 'DrugGeneTargets_v2_4135', 'drugName': 'Rwj-67657', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'MAPK11 (ENSG00000185386), MAPK14 (ENSG00000112062)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 1, 'drugIsApproved': False}, {'UUID': 'DrugGeneTargets_v2_413... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.911 | Q58 | How many genes does the drug Tebentafusp target and what are they? | PMEL is the only gene target of drug Tebentafusp. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%tebentafusp%" OR LOWER(tradeNames_string) LIKE "... | [{'UUID': 'DrugGeneTargets_v2_5977', 'drugName': 'Tebentafusp', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'PMEL (ENSG00000185664)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2022, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.922 | Q58 | How many genes does the drug Diphenhydramine Hydrochloride target and what are they? | HRH1 is the only gene target of drug Diphenhydramine Hydrochloride. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%diphenhydramine hydrochloride%" OR LOWER(tradeNa... | [{'UUID': 'DrugGeneTargets_v2_2888', 'drugName': 'Diphenhydramine Hydrochloride', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'HRH1 (ENSG00000196639)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1946, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_1015', 'd... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1679 | Q58 | How many genes does the drug Benztropine target and what are they? | CHRM1 is the only gene target of drug Benztropine. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%benztropine%" OR LOWER(tradeNames_string) LIKE "... | [{'UUID': 'DrugGeneTargets_v2_321', 'drugName': 'Benztropine Mesylate', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'CHRM1 (ENSG00000168539)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1954, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_2039', 'drugName':... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1272 | Q58 | How many genes does the drug Bupivacaine target and what are they? | SCN4A is the only gene target of drug Bupivacaine. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%bupivacaine%" OR LOWER(tradeNames_string) LIKE "... | [{'UUID': 'DrugGeneTargets_v2_5747', 'drugName': 'Bupivacaine', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'SCN4A (ENSG00000007314)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1972, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_1687', 'drugName': 'Bupiva... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1094 | Q58 | How many genes does the drug Galeterone target and what are they? | The drug Galeterone is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 2 genes: AR and CYP17A1. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%galeterone%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_1889', 'drugName': 'Galeterone', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'AR (ENSG00000169083), CYP17A1 (ENSG00000148795)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 3, 'drugIsApproved': False}, {'UUID': 'DrugGeneTargets_v2_1890'... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.389 | Q58 | How many genes does the drug Pseudoephedrine Sulfate target and what are they? | SLC6A2 is the only gene target of drug Pseudoephedrine Sulfate. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%pseudoephedrine sulfate%" OR LOWER(tradeNames_st... | [{'UUID': 'DrugGeneTargets_v2_1353', 'drugName': 'Pseudoephedrine Sulfate', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'SLC6A2 (ENSG00000103546)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1963, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.841 | Q58 | How many genes does the drug Gonadorelin target and what are they? | GNRHR is the only gene target of drug Gonadorelin. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%gonadorelin%" OR LOWER(tradeNames_string) LIKE "... | [{'UUID': 'DrugGeneTargets_v2_515', 'drugName': 'Gonadorelin', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'GNRHR (ENSG00000109163)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1982, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_3355', 'drugName': 'Gonadorelin Ac... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.774 | Q58 | How many genes does the drug Ibandronate Sodium target and what are they? | FDPS is the only gene target of drug Ibandronate Sodium. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%ibandronate sodium%" OR LOWER(tradeNames_string)... | [{'UUID': 'DrugGeneTargets_v2_2230', 'drugName': 'Ibandronate Sodium', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'FDPS (ENSG00000160752)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2003, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1805 | Q58 | How many genes does the drug Pasireotide Diaspartate target and what are they? | There are 4 gene targets for the drug Pasireotide Diaspartate: SSTR3, SSTR2, SSTR1, and SSTR5. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%pasireotide diaspartate%" OR LOWER(tradeNames_st... | [{'UUID': 'DrugGeneTargets_v2_1407', 'drugName': 'Pasireotide Diaspartate', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'SSTR3 (ENSG00000278195), SSTR2 (ENSG00000180616), SSTR1 (ENSG00000139874), SSTR5 (ENSG00000162009)', 'numberLinkedTargets': 4, 'yearOfFirstApproval': 2012, 'maxClinicalTrialPhase': 4, ... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1992 | Q58 | How many genes does the drug Rosmantuzumab target and what are they? | The drug Rosmantuzumab is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 2 genes: RSPO3 and LGR4. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%rosmantuzumab%" OR LOWER(tradeNames_string) LIKE... | [{'UUID': 'DrugGeneTargets_v2_5619', 'drugName': 'Rosmantuzumab', 'drugMolecularType': 'Antibody', 'newLinkedTargets_string': 'RSPO3 (ENSG00000146374), LGR4 (ENSG00000205213)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 3, 'drugIsApproved': False}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1066 | Q58 | How many genes does the drug Rimexolone target and what are they? | NR3C1 is the only gene target of drug Rimexolone. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%rimexolone%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_5317', 'drugName': 'Rimexolone', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'NR3C1 (ENSG00000113580)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1994, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.58 | Q58 | How many genes does the drug Tarloxotinib target and what are they? | The drug Tarloxotinib is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 4 genes: ERBB2, EGFR, ERBB4, and ERBB3. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%tarloxotinib%" OR LOWER(tradeNames_string) LIKE ... | [{'UUID': 'DrugGeneTargets_v2_418', 'drugName': 'Tarloxotinib', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361)', 'numberLinkedTargets': 4, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 2, 'drugIsAp... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1688 | Q58 | How many genes does the drug Ebrotidine target and what are they? | HRH2 is the only gene target of drug Ebrotidine. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%ebrotidine%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_4636', 'drugName': 'Ebrotidine', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'HRH2 (ENSG00000113749)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_4637', 'drugName': 'Ebrotidine'... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1955 | Q58 | How many genes does the drug Setmelanotide Acetate target and what are they? | MC4R is the only gene target of drug Setmelanotide Acetate. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%setmelanotide acetate%" OR LOWER(tradeNames_stri... | [{'UUID': 'DrugGeneTargets_v2_2878', 'drugName': 'Setmelanotide Acetate', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'MC4R (ENSG00000166603)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2020, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1218 | Q58 | How many genes does the drug Primidone target and what are they? | There are 26 gene targets for the drug Primidone: SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, SCN9A, SCN3A, SCN11A, SCN8A, SCN10A, GABRA1, GABRB2, GABRG2, GABRB3, GABRA4, GABRG3, GABRQ, GABRA3, GABRP, GABRD, GABRG1, GABRB1, GABRE, GABRA2, GABRA5, and GABRA6. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%primidone%" OR LOWER(tradeNames_string) LIKE "%p... | [{'UUID': 'DrugGeneTargets_v2_1073', 'drugName': 'Primidone', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG0000... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1680 | Q58 | How many genes does the drug Hydroxychloroquine target and what are they? | There are 2 gene targets for the drug Hydroxychloroquine: TLR7 and TLR9. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%hydroxychloroquine%" OR LOWER(tradeNames_string)... | [{'UUID': 'DrugGeneTargets_v2_963', 'drugName': 'Hydroxychloroquine', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'TLR7 (ENSG00000196664), TLR9 (ENSG00000239732)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 1955, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1975 | Q58 | How many genes does the drug Linzagolix target and what are they? | GNRHR is the only gene target of drug Linzagolix. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%linzagolix%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_628', 'drugName': 'Linzagolix', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'GNRHR (ENSG00000109163)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.213 | Q58 | How many genes does the drug Valdecoxib target and what are they? | PTGS2 is the only gene target of drug Valdecoxib. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%valdecoxib%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_5955', 'drugName': 'Valdecoxib', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2001, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1534 | Q58 | How many genes does the drug Fosaprepitant target and what are they? | TACR1 is the only gene target of drug Fosaprepitant. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%fosaprepitant%" OR LOWER(tradeNames_string) LIKE... | [{'UUID': 'DrugGeneTargets_v2_5495', 'drugName': 'Fosaprepitant Dimeglumine', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'TACR1 (ENSG00000115353)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2008, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_542', 'drugN... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1135 | Q58 | How many genes does the drug Dextromethorphan target and what are they? | There are 2 gene targets for the drug Dextromethorphan: GRIN2A and SIGMAR1. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%dextromethorphan%" OR LOWER(tradeNames_string) L... | [{'UUID': 'DrugGeneTargets_v2_3605', 'drugName': 'Dextromethorphan Polistirex', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'GRIN2A (ENSG00000183454), SIGMAR1 (ENSG00000147955)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 1982, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'D... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.131 | Q58 | How many genes does the drug Rafabegron target and what are they? | The drug Rafabegron is not approved by the FDA. However, it is currently undergoing clinical trials and indecated to target the gene ADRB3. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%rafabegron%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_2385', 'drugName': 'Rafabegron', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'ADRB3 (ENSG00000188778)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 2, 'drugIsApproved': False}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.819 | Q58 | How many genes does the drug Calcitonin Salmon Recombinant target and what are they? | CALCR is the only gene target of drug Calcitonin Salmon Recombinant. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%calcitonin salmon recombinant%" OR LOWER(tradeNa... | [{'UUID': 'DrugGeneTargets_v2_4748', 'drugName': 'Calcitonin Salmon Recombinant', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'CALCR (ENSG00000004948)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2005, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1282 | Q58 | How many genes does the drug Ramelteon target and what are they? | There are 2 gene targets for the drug Ramelteon: MTNR1A and MTNR1B. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%ramelteon%" OR LOWER(tradeNames_string) LIKE "%r... | [{'UUID': 'DrugGeneTargets_v2_5938', 'drugName': 'Ramelteon', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'MTNR1A (ENSG00000168412), MTNR1B (ENSG00000134640)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 2005, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1872 | Q58 | How many genes does the drug Guanethidine Monosulfate target and what are they? | SLC6A2 is the only gene target of drug Guanethidine Monosulfate. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%guanethidine monosulfate%" OR LOWER(tradeNames_s... | [{'UUID': 'DrugGeneTargets_v2_2340', 'drugName': 'Guanethidine Monosulfate', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'SLC6A2 (ENSG00000103546)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1960, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.438 | Q58 | How many genes does the drug Mecasermin target and what are they? | IGF1R is the only gene target of drug Mecasermin. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%mecasermin%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_672', 'drugName': 'Mecasermin Rinfabate', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'IGF1R (ENSG00000140443)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2005, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_2750', 'drugName': 'Mecas... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.417 | Q58 | How many genes does the drug Ketamine target and what are they? | There are 7 gene targets for the drug Ketamine: GRIN1, GRIN2A, GRIN2B, GRIN2D, GRIN3B, GRIN2C, and GRIN3A. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%ketamine%" OR LOWER(tradeNames_string) LIKE "%ke... | [{'UUID': 'DrugGeneTargets_v2_2915', 'drugName': 'Ketamine', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785)', 'numberLin... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1504 | Q58 | How many genes does the drug Hepalatide target and what are they? | The drug Hepalatide is not approved by the FDA. However, it is currently undergoing clinical trials and indecated to target the gene SLC10A1. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%hepalatide%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_6299', 'drugName': 'Hepalatide', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'SLC10A1 (ENSG00000100652)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 2, 'drugIsApproved': False}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.234 | Q58 | How many genes does the drug Mexiletine target and what are they? | There are 10 gene targets for the drug Mexiletine: SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, SCN9A, SCN3A, SCN11A, SCN8A, and SCN10A. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%mexiletine%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_485', 'drugName': 'Mexiletine', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG0000... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1708 | Q58 | How many genes does the drug Cp-459632 target and what are they? | The drug Cp-459632 is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 8 genes: TIE1, FLT1, FLT4, KDR, FGFR3, FGFR1, FGFR4, and FGFR2. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%cp-459632%" OR LOWER(tradeNames_string) LIKE "%c... | [{'UUID': 'DrugGeneTargets_v2_1414', 'drugName': 'Cp-459632', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'TIE1 (ENSG00000066056), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG0000006646... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.895 | Q58 | How many genes does the drug Labetalol Hydrochloride target and what are they? | There are 9 gene targets for the drug Labetalol Hydrochloride: ADRA1A, ADRA2A, ADRB1, ADRB2, ADRA2C, ADRA1D, ADRA1B, ADRA2B, and ADRB3. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%labetalol hydrochloride%" OR LOWER(tradeNames_st... | [{'UUID': 'DrugGeneTargets_v2_5404', 'drugName': 'Labetalol Hydrochloride', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'ADRA1A (ENSG00000120907), ADRA2A (ENSG00000150594), ADRB1 (ENSG00000043591), ADRB2 (ENSG00000169252), ADRA2C (ENSG00000184160), ADRA1D (ENSG00000171873), ADRA1B (ENSG00000170214... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1625 | Q58 | How many genes does the drug Danicamtiv target and what are they? | The drug Danicamtiv is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 7 genes: MYH7, MYH6, MYH7B, MYL3, MYL2, MYL7, and MYL4. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%danicamtiv%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_2405', 'drugName': 'Danicamtiv', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'MYH7 (ENSG00000092054), MYH6 (ENSG00000197616), MYH7B (ENSG00000078814), MYL3 (ENSG00000160808), MYL2 (ENSG00000111245), MYL7 (ENSG00000106631), MYL4 (ENSG00000198336)', 'numberLinkedTargets... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.699 | Q58 | How many genes does the drug Chlorothiazide target and what are they? | SLC12A3 is the only gene target of drug Chlorothiazide. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%chlorothiazide%" OR LOWER(tradeNames_string) LIK... | [{'UUID': 'DrugGeneTargets_v2_4705', 'drugName': 'Chlorothiazide', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'SLC12A3 (ENSG00000070915)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1958, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_1678', 'drugName': 'H... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1769 | Q58 | How many genes does the drug Bazedoxifene Acetate target and what are they? | There are 2 gene targets for the drug Bazedoxifene Acetate: ESR2 and ESR1. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%bazedoxifene acetate%" OR LOWER(tradeNames_strin... | [{'UUID': 'DrugGeneTargets_v2_1341', 'drugName': 'Bazedoxifene Acetate', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 2009, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.301 | Q58 | How many genes does the drug Anagrelide Hydrochloride target and what are they? | There are 2 gene targets for the drug Anagrelide Hydrochloride: PDE3A and PDE3B. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%anagrelide hydrochloride%" OR LOWER(tradeNames_s... | [{'UUID': 'DrugGeneTargets_v2_350', 'drugName': 'Anagrelide Hydrochloride', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'PDE3A (ENSG00000172572), PDE3B (ENSG00000152270)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 1997, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1399 | Q58 | How many genes does the drug Ketotifen target and what are they? | HRH1 is the only gene target of drug Ketotifen. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%ketotifen%" OR LOWER(tradeNames_string) LIKE "%k... | [{'UUID': 'DrugGeneTargets_v2_5638', 'drugName': 'Ketotifen Fumarate', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'HRH1 (ENSG00000196639)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1999, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_5435', 'drugName': '... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1987 | Q58 | How many genes does the drug Berotralstat target and what are they? | KLKB1 is the only gene target of drug Berotralstat. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%berotralstat%" OR LOWER(tradeNames_string) LIKE ... | [{'UUID': 'DrugGeneTargets_v2_1536', 'drugName': 'Berotralstat', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'KLKB1 (ENSG00000164344)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2020, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_4296', 'drugName': 'Berot... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.102 | Q58 | How many genes does the drug Reboxetine target and what are they? | SLC6A2 is the only gene target of drug Reboxetine. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%reboxetine%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_2138', 'drugName': 'Reboxetine', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'SLC6A2 (ENSG00000103546)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_1202', 'drugName': 'Esreboxet... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.831 | Q58 | How many genes does the drug Treprostinil target and what are they? | PTGIR is the only gene target of drug Treprostinil. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%treprostinil%" OR LOWER(tradeNames_string) LIKE ... | [{'UUID': 'DrugGeneTargets_v2_1758', 'drugName': 'Treprostinil', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'PTGIR (ENSG00000160013)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2002, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_2433', 'drugName': 'Trepr... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.359 | Q58 | How many genes does the drug Balsalazide target and what are they? | There are 4 gene targets for the drug Balsalazide: PPARG, PTGS2, PTGS1, and ALOX5. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%balsalazide%" OR LOWER(tradeNames_string) LIKE "... | [{'UUID': 'DrugGeneTargets_v2_1298', 'drugName': 'Balsalazide Disodium', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'PPARG (ENSG00000132170), PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303), ALOX5 (ENSG00000012779)', 'numberLinkedTargets': 4, 'yearOfFirstApproval': 2000, 'maxClinicalTrialPhase':... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.114 | Q58 | How many genes does the drug Plx-7486 target and what are they? | The drug Plx-7486 is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 4 genes: CSF1R, NTRK2, NTRK1, and NTRK3. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%plx-7486%" OR LOWER(tradeNames_string) LIKE "%pl... | [{'UUID': 'DrugGeneTargets_v2_5730', 'drugName': 'Plx-7486', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'CSF1R (ENSG00000182578), NTRK2 (ENSG00000148053), NTRK1 (ENSG00000198400), NTRK3 (ENSG00000140538)', 'numberLinkedTargets': 4, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 1, 'drugIsAppr... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1440 | Q58 | How many genes does the drug Estetrol target and what are they? | There are 2 gene targets for the drug Estetrol: ESR2 and ESR1. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%estetrol%" OR LOWER(tradeNames_string) LIKE "%es... | [{'UUID': 'DrugGeneTargets_v2_4568', 'drugName': 'Estetrol', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 2021, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1840 | Q58 | How many genes does the drug Gsk2982772 target and what are they? | The drug Gsk2982772 is not approved by the FDA. However, it is currently undergoing clinical trials and indecated to target the gene RIPK1. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%gsk2982772%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_4958', 'drugName': 'Gsk2982772', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'RIPK1 (ENSG00000137275)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 2, 'drugIsApproved': False}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.952 | Q58 | How many genes does the drug Cetuximab target and what are they? | EGFR is the only gene target of drug Cetuximab. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%cetuximab%" OR LOWER(tradeNames_string) LIKE "%c... | [{'UUID': 'DrugGeneTargets_v2_1080', 'drugName': 'Cetuximab', 'drugMolecularType': 'Antibody', 'newLinkedTargets_string': 'EGFR (ENSG00000146648)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2004, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_3231', 'drugName': 'Cetuximab Sarot... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1186 | Q58 | How many genes does the drug Enpatoran target and what are they? | The drug Enpatoran is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 2 genes: TLR8 and TLR7. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%enpatoran%" OR LOWER(tradeNames_string) LIKE "%e... | [{'UUID': 'DrugGeneTargets_v2_2098', 'drugName': 'Enpatoran', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'TLR8 (ENSG00000101916), TLR7 (ENSG00000196664)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 2, 'drugIsApproved': False}, {'UUID': 'DrugGeneTargets_v2_2099', ... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.456 | Q58 | How many genes does the drug Tilpisertib target and what are they? | The drug Tilpisertib is not approved by the FDA. However, it is currently undergoing clinical trials and indecated to target the gene MAP3K8. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%tilpisertib%" OR LOWER(tradeNames_string) LIKE "... | [{'UUID': 'DrugGeneTargets_v2_6134', 'drugName': 'Tilpisertib', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'MAP3K8 (ENSG00000107968)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 2, 'drugIsApproved': False}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.876 | Q58 | How many genes does the drug Moexipril target and what are they? | ACE is the only gene target of drug Moexipril. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%moexipril%" OR LOWER(tradeNames_string) LIKE "%m... | [{'UUID': 'DrugGeneTargets_v2_4629', 'drugName': 'Moexipril', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'ACE (ENSG00000159640)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1995, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_517', 'drugName': 'Moexipril H... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1545 | Q58 | How many genes does the drug Eteplirsen target and what are they? | DMD is the only gene target of drug Eteplirsen. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%eteplirsen%" OR LOWER(tradeNames_string) LIKE "%... | [{'UUID': 'DrugGeneTargets_v2_3184', 'drugName': 'Eteplirsen', 'drugMolecularType': 'Oligonucleotide', 'newLinkedTargets_string': 'DMD (ENSG00000198947)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2016, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1701 | Q58 | How many genes does the drug Gonadorelin Acetate target and what are they? | GNRHR is the only gene target of drug Gonadorelin Acetate. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%gonadorelin acetate%" OR LOWER(tradeNames_string... | [{'UUID': 'DrugGeneTargets_v2_3355', 'drugName': 'Gonadorelin Acetate', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'GNRHR (ENSG00000109163)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 1989, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}] | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1436 | Q58 | How many genes does the drug Bremelanotide target and what are they? | MC4R is the only gene target of drug Bremelanotide. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%bremelanotide%" OR LOWER(tradeNames_string) LIKE... | [{'UUID': 'DrugGeneTargets_v2_177', 'drugName': 'Bremelanotide Acetate', 'drugMolecularType': 'Protein', 'newLinkedTargets_string': 'MC4R (ENSG00000166603)', 'numberLinkedTargets': 1, 'yearOfFirstApproval': 2019, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2_4990', 'drugName': 'Breme... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.915 | Q58 | How many genes does the drug Aminophylline target and what are they? | There are 10 gene targets for the drug Aminophylline: PDE4A, PDE4D, PDE4B, PDE4C, PDE3A, PDE3B, ADORA1, ADORA2B, ADORA3, and ADORA2A. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%aminophylline%" OR LOWER(tradeNames_string) LIKE... | [{'UUID': 'DrugGeneTargets_v2_5470', 'drugName': 'Aminophylline', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), ADORA1 (ENSG00000163485), ADORA2B (EN... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.310 | Q58 | How many genes does the drug Lemborexant target and what are they? | There are 2 gene targets for the drug Lemborexant: HCRTR2 and HCRTR1. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%lemborexant%" OR LOWER(tradeNames_string) LIKE "... | [{'UUID': 'DrugGeneTargets_v2_1217', 'drugName': 'Lemborexant', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'HCRTR2 (ENSG00000137252), HCRTR1 (ENSG00000121764)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 2020, 'maxClinicalTrialPhase': 4, 'drugIsApproved': True}, {'UUID': 'DrugGeneTargets_v2... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1257 | Q58 | How many genes does the drug Muraglitazar target and what are they? | The drug Muraglitazar is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 2 genes: PPARA and PPARG. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%muraglitazar%" OR LOWER(tradeNames_string) LIKE ... | [{'UUID': 'DrugGeneTargets_v2_6342', 'drugName': 'Muraglitazar', 'drugMolecularType': 'Small molecule', 'newLinkedTargets_string': 'PPARA (ENSG00000186951), PPARG (ENSG00000132170)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 3, 'drugIsApproved': False}, {'UUID': 'DrugGeneTargets_v2_63... | general | Distinct, Order By, Similarity Search | Genetic Target |
Q58.1409 | Q58 | How many genes does the drug Vanucizumab target and what are they? | The drug Vanucizumab is not approved by the FDA. However, it is currently undergoing clinical trials and indicated to target 2 genes: ANGPT2 and VEGFA. | SELECT DISTINCT UUID, drugName, drugMolecularType, newLinkedTargets_string, numberLinkedTargets, yearOfFirstApproval, maxClinicalTrialPhase, drugIsApproved
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE (LOWER(drugName) LIKE "%vanucizumab%" OR LOWER(tradeNames_string) LIKE "... | [{'UUID': 'DrugGeneTargets_v2_2714', 'drugName': 'Vanucizumab', 'drugMolecularType': 'Antibody', 'newLinkedTargets_string': 'ANGPT2 (ENSG00000091879), VEGFA (ENSG00000112715)', 'numberLinkedTargets': 2, 'yearOfFirstApproval': 0, 'maxClinicalTrialPhase': 2, 'drugIsApproved': False}, {'UUID': 'DrugGeneTargets_v2_2715', '... | general | Distinct, Order By, Similarity Search | Genetic Target |
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