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vitamin\tC,\tbeta-carotene,\ncalcium,\tiron,\tand\nmagnesium\nOnly\tthose\tfoods\tthat\tcause\tsymptoms\tshould\nbe\texcluded,\tensuring\tthat\ta\tvariety\tof\nother\tplant\tfoods\tare\tconsumed.\nIndividuals\twith\tPFAS\tcan\tusually\ttolerate\nproblematic\tfoods\twhen\tthey\tcooked\nor\tprocessed.\nSeafood\nProtein,\... | [
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Protein,\tcalcium\t(fish\tbones),\niodine,\tvitamins\tA\tand\tD,\nvitamin\tB\n12\n,\tomega-3\tfatty\nacids\nIndividuals\twith\tseafood\tallergy\tare\trarely\nallergic\tto\tall\tseafood.\tPeople\twith\tfish\nallergy\tmay\tbe\table\tto\teat\tshellfish,\tand\nthose\tallergic\tto\tshellfish\tmay\ttolerate\tfin\nfish.\tEven... | [
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be\ttolerant\tof\tother\ttypes\tof\n\tshellfish\t(e.g.,\nan\tindividual\tallergic\tto\tprawns\n[crustaceans]\tmay\tbe\table\tto\teat\tmollusks,\ne.g.\tclams,\tmussels,\tscallops,\tor\toysters).\nFlaxseeds/linseeds\tare\talso\ta\tsource\tof\nomega-3\tfatty\tacids,\tas\tare\tsome\nanimal\tproducts\tto\ta\tlimited\textent... | [
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Iodine\tis\tadded\tto\tiodized\ttable\tsalt.\tSea\ngreens,\tmilk,\tand\teggs\tare\tother\nsources\tof\tiodine.\nSoy\tand\nother\nlegumes\nEnergy,\tprotein,\tfiber,\tB\nvitamins,\n\tcalcium,\nmagnesium,\tiron,\tand\tzinc\nSoy\tand\tother\tlegumes,\talong\twith\tnuts,\tare\nsignificant\tsources\tof\tprotein\tin\tplant-\n... | [
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based\tdiets.\tWhole\tgrains\tare\talso\tan\nimportant\tsource.\tIt\tis\timportant\tthat\tonly\nthose\tfoods\tcausing\tsymptoms\tare\navoided.\nWheat\nEnergy,\tprotein,\tfiber,\tB\nvitamins\t(folic\tacid,\nniacin,\tpantothenic\tacid,\nriboflavin,\tthiamin,\tB\n6\n),\niron,\tmagnesium,\nphosphorous,\tselenium,\nzinc\nA\... | [
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zinc\nA\tvariety\tof\tnonwheat\tflours\tare\tavailable\tfor\ncooking\tand\tbaking,\tsuch\tas\toat,\tbarley,\nrye,\tamaranth,\tbuckwheat,\tmillet,\tquinoa,\nrice,\tsorghum,\ttapioca,\tand\tteff.\nMilk\tand\teggs\tprovide\tenergy,\tprotein,\ncalcium,\tand\tB\tvitamins.\nFiber\tcan\tbe\tobtained\tfrom\tother\tplant\nfoods... | [
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foods.\nGood\tsources\tof\tiron\tare\nmeat/fish/poultry\tand\tsome\tplant\nfoods.\tIron\tsupplementation\tmay\tbe\nThe\tgrains\tbarley,\noat,\tand\trye\nmust\talso\tbe\navoided\twhen\ngluten\talso\nneeds\tto\tbe\talso\nbe\teliminated.\nFiber\tcan\tbe\nobtained\nfrom\tother\nwhole\tgrains | [
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necessary.\nThose\tavoiding\tboth\n\tmilk\tand\twheat,\nespecially\tif\tvegetarian\tor\tvegan,\tmay\nneed\tsupplements\tof\tB\tvitamins,\ncalcium,\tiron,\tand\ttrace\tminerals.\nand\tplant\nfoods.\nBecause\tfood\tis\tan\timportant\tpart\tof\ta\tperson’s\tculture,\tthe\tsocial\taspects\tof\teating\tcan\tmake\nadherence | [
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adherence\n\tto\tan\telimination\tdiet\tchallenging.\tNutritional\tissues\tcan\talso\tarise\tdue\tto\tincreased\tanxiety\nand\tstress\tencountered\twith\tchanges\tin\tlifestyle\tassociated\twith\telimination\tdiets.\tIn\taddition,\tthe\nplethora\tof\tonline\tsources\tof\tinformation\tand\tsocial\tmedia\tnow\tavailable\... | [
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confusion\tabout\twhat\tis\tbest\tto\teat\t(\nSkypala\tand\tMcKenzie,\t2018\n).\tContinued\tpersonalized\tdietary\nsupport\n\tfrom\tan\texperienced\tregistered\tdietitian\tnutritionist\t(RDN)\tis\tneeded\tto\toptimally\tguide\tpatients\nmanaging\tfood\tallergies\tand\tintolerances\tand\tto\tminimize\tthe\teffect\tof\td... | [
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family\tand\tsocial\tlife.\tStrategies\tlisted\tin\t\nBox\t25.8\n\tcan\thelp\tfamilies\tand\tindividuals\tcope\twith\tadverse\nfood\treactions\tand\tstill\tmaintain\tquality\tof\tlife.\nBOX\t25.8\nStrategies\tfor\tCoping\twith\n\t\nFood\tAllergy\nFood\tsubstitutions\nTry\tto\tsubstitute\titem-for-item\tat\tmeals.\tFor\... | [
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substitution\tof\ta\tgluten-free\tpasta\tmay\tbe\tbetter\taccepted\tfor\tthe\tgluten-sensitive\tor\twheat-allergic\nperson\tthan\ta\tdissimilar\titem.\nDining\tout\tand\teating\taway\tfrom\thome\nEating\tmeals\taway\tfrom\thome\tcan\tbe\trisky\tfor\tindividuals\twith\tfood\tallergies.\tWhether\tat\ta\n\tfancy | [
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fancy\nrestaurant\tor\ta\tfast-food\testablishment,\tinadvertent\texposure\tto\tan\tallergen\tcan\toccur,\teven\tamong\nthe\tmost\tknowledgeable\tindividuals.\tHere\tare\tsome\tprecautions\tto\ttake:\n•\t\nBring\t“safe”\tfoods\talong\tto\tmake\teating\tout\teasier.\tFor\tbreakfast,\tbring\talong\tan\tappropriate\nmilk\... | [
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milk\tif\tothers\twill\tbe\thaving\tcereal\twith\tmilk.\n•\t\nAlert\tthe\twait\tstaff\tto\tthe\tpotential\tseverity\tof\tthe\tfood\tallergy\tor\n\tallergies.\n•\t\nQuestion\tthe\twait\tstaff\tcarefully\tabout\tingredients.\n•\t\nAlways\tcarry\tmedications.\nSpecial\toccasions\nCall\tthe\thost\tfamily\tin\tadvance\tto\t... | [
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acceptable\tdish\tthat\tall\tcan\tenjoy.\nGrocery\tshopping\nBe\tinformed\tabout\twhat\tfoods\tare\tacceptable\tand\tread\tlabels\tcarefully.\tProduct\tingredients\tchange\nover\ttime;\tcontinue\tto\tread\tthe\tlabels\n\ton\tfoods,\teven\tif\tthey\twere\tpreviously\tdetermined\tto\tbe\t“safe”\nfoods.\tAllow\tfor\tthe\t... | [
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Label\treading\nLabeling\tlegislation\t(see\t\nBox\t25.7\n)\tmakes\tit\teasier\tto\tidentify\tcertain\tpotential\tallergens\tfrom\tthe\ningredient\tlist\ton\tfood\tlabels.\tFor\texample,\twhen\tfood\tmanufacturers\tuse\tprotein\thydrolysates\tor\nhydrolyzed\tvegetable\tprotein,\tthey\tmust\tnow\tspecify\tthe\tsource\n\... | [
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0.0126853... |
of\tprotein\tused\t(e.g.,\thydrolyzed\tsoy\nor\thydrolyzed\tcorn).\tAlthough\treactions\tto\tfood\tcolors\tor\tfood\tdyes\tare\trare,\tindividuals\twho\tsuspect\nan\tintolerance\twill\tfind\tthem\tlisted\tseparately\ton\tthe\tfood\tlabel,\trather\tthan\tcategorized\tsimply\tas\n“food\tcolor.”\nEarly\tfeeding\n•\tExclus... | [
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Early\tfeeding\n•\tExclusive\tbreastfeeding\tfor\t4\tto\t6\tmonths\n•\tIf\texclusive\tbreastfeeding\tis\tnot\tpossible,\tuse\twhey-based,\tpartially\thydrolyzed\n\tformula\nIntroduction\tof\tcomplementary\tfoods\n•\t\nFrom\t4\tmonths,\tearly\tintroduction\tof\tpotential\tfood\tallergens\t(peanut,\tegg,\tand\tothers)\ti... | [
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at\thigh\trisk\tof\tdeveloping\tfood\tallergies\nMicrobiome-modifying\tinterventions\n•\t\nHuman\tmilk\toligosaccharides\n•\t\nPrebiotics\t(e.g.,\tfructo-oligosaccharides\tand\tgalacto-oligosaccharides)\n•\t\nProbiotics\t(e.g.,\t\nLactobacillus\trhamnosus\n)\nImmune\tmodulating\n\tnutrients\n• | [
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Lactobacillus\trhamnosus\n)\nImmune\tmodulating\n\tnutrients\n•\t\nMaternal\tomega-3\tpolyunsaturated\tfatty\tacid\tsupplementation\t(docosahexaenoic\tacid\t(DHA)\tand\neicosapentaenoic\tacid\t(EPA)\n•\t\nVitamin\tD\nGeneral\n•\t\nStrengthen\timmunity\tby\tincreasing\tconnection\tto\tnatural\tenvironments,\tpets,\tand\... | [
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•\t\nStrengthen\timmunity\tby\tregular\texercise\n•\t\nConsume\tfermented\tfood\tor\tother\tprobiotic\tpreparations\tto\tstrengthen\timmune\tsystem\n•\t\nUse\tantibiotics\n\tonly\twhen\tnecessary;\tthe\tmajority\tof\tmicrobes\tare\tuseful\tand\thelp\tbuild\thealthy\nimmune\tfunction\n•\t\nDo\tnot\tsmoke;\tparental\tand... | [
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asthma\nSources:\tHeine\tRG:\tFood\tallergy\tprevention\tand\ttreatment\tby\ttargeted\tnutrition,\t\nAnn\tNutr\tMetabol\n\t72(suppl\n3):34,\t2018.\t\nHaahtela\tT\tet\tal:\tThe\tbiodiversity\thypothesis\tand\tallergic\tdisease:\tworld\tallergy\n\torganization\tposition\nstatement,\t\nWorld\tAllergy\tOrgan\n\tJ\t6:3,\t20... | [
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World\tAllergy\tOrgan\n\tJ\t6:3,\t2013.\nPrevention\tof\tfood\tallergies\nIntensive\tresearch\tis\tbeing\tfocused\ton\tprevention\tstrategies\tfor\tallergic\tdisease,\twith\temphasis\ton\npotential\tgenetic,\tepigenetic,\tenvironmental,\tand\tmodifiable\tlifestyle\trisk\tfactors.\tThere\tis\tgrowing | [
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interest\tin\tthe\trole\tof\tmicrobiome-based\ttherapies\tin\tan\tattempt\tto\tpromote\timmunologic\n\ttolerance\tand\nthe\tcentral\trole\tthat\tnutritional\tinterventions\tplay\tin\tmanipulating\tthe\tmicrobiome.\tPrimary\tfood\tallergy\nprevention\taims\tto\treduce\tthe\tinfant’s\trisk\tof\tsensitization\tto\tfood\ta... | [
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prevention\taims\tto\tprevent\tthe\tclinical\texpression\tof\tallergic\tdisease\tin\tindividuals\twho\tare\teither\nallergen\tsensitized\tor\twho\talready\tmanifest\tother\tallergic\tdisorders\tsuch\n\tas\teczema\tor\tasthma.\tAllergy\nprevention\tguidelines\thave\tgradually\tshifted\taway\tfrom\tprolonged\tallergen\ta... | [
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0.05934473127126694,
0.0... |
on\tthe\tearly\tintroduction\tof\tcomplementary\tor\t“solid\tfoods”\tinto\tthe\tdiets\tof\tinfants\t(\nHeine,\t2018\n;\t\nWest,\n2017\n).\nThe\tCanadian\tHealthy\tInfant\tLongitudinal\tDevelopment\t(CHILD)\tstudy\tis\tone\tof\tthe\tlargest\tlongitudinal\nstudies,\tinvolving\tmore\tthan\t1000\tCanadian\tmothers\n\tand\t... | [
-0.01115410216152668,
-0.014252247288823128,
0.05855301767587662,
-0.05839657783508301,
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0.03621836379170418,
0.055508747696876526,
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0.0646195039153099,
0.1167670413851738,
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0.02142452448606491,
0.006827... |
and\tinfants,\tto\tadvance\tknowledge\tabout\tthe\ngenetic\tand\tenvironmental\tdeterminants\tof\tatopic\tdiseases\t(\nCHILD\tstudy,\t2018\n).\tData\tfrom\tthis\tstudy\tand\nothers\thave\tcontributed\tto\tguidelines\ton\tprevention\tand\tinterventions\tthat\tappear\tto\treduce\tthe\trisk\tof\ndeveloping\tfood\tallergy\... | [
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0.058966729789972305,
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0.06520935893058777,
0.10343829542398453,
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0.02820619009435177,
-0.0... |
developing\tfood\tallergy\t(\nBox\t25.9\n).\tA\tnumber\tof\thypotheses\thave\tbeen\tproposed\tfor\tthe\tprevention\tof\nfood\tallergy\tthat\twarrant\tfurther\texamination.\nBOX\t25.9\nRecommendations\tto\tPromote\tOral\tTolerance\tand\tPrevent\tAllergy\n•\t\nSupport\tbreastfeeding\tand\tdelay\tintroduction\tof\tsolid\t... | [
0.014975673519074917,
-0.025258556008338928,
0.0020143878646194935,
-0.008000095374882221,
-0.02792242169380188,
0.026161301881074905,
-0.00013912940630689263,
0.025134915485978127,
-0.05121895298361778,
0.05203630030155182,
0.1702573299407959,
-0.03535362333059311,
0.014063997194170952,
-... |
•\t\nStrengthen\timmunity\tby\tincreasing\tconnection\tto\tnatural\tenvironments,\tpets,\tand\tfarms.\n•\t\nStrengthen\timmunity\tby\tregular\tphysical\texercise.\n•\t\nUse\tantibiotics\tonly\twhen\tnecessary;\tthe\tmajority\tof\tmicrobes\tare\tuseful\tand\thelp\tbuild\n\thealthy\nimmune\tfunction.\n•\t\nConsume\tferme... | [
0.013146620243787766,
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0.05335608497262001,
-0.007146481424570084,
-0.11039701849222183,
0.01517600566148758,
0.08376321196556091,
0.04657674580812454,
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0.04836472496390343,
0.10928206145763397,
-0.06643263250589371,
0.02855386771261692,
0.0431116... |
•\t\nDo\tnot\tsmoke:\tparental\tand\tfamily\tsmoking\taround\tinfants\tand\tchildren\tcan\tincrease\trisk\tof\nasthma.\nFrom\tHaahtela\tT\tet\tal:\tThe\tbiodiversity\thypothesis\tand\tallergic\tdisease:\tworld\tallergy\torganization\tposition\nstatement,\t\nWorld\tAllergy\tOrgan\tJ\n\t6:3,\t2013.\nMicrobial\texposure\n... | [
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0.04598144069314003,
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0.08720466494560242,
0.09785211831331253,
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0.015378451906144619,
0.00943... |
World\tAllergy\tOrgan\tJ\n\t6:3,\t2013.\nMicrobial\texposure\n\thypotheses\nThe\tinterplay\tbetween\tthe\tgut\tmicrobiome\tand\tenvironmental\tmicrobial\tburden\tplays\ta\tmajor\trole\tin\tthe\nimmunologic\tevents\tthat\tlead\tto\tfood\tallergy\t(\nHeine,\t2018\n).\tThe\tmicrobial\thypothesis\tproposes\tthat\ta | [
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0.10470663756132126,
0.1022309884428978,
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0.0187... |
Heine,\t2018\n).\tThe\tmicrobial\thypothesis\tproposes\tthat\ta\ndecrease\tin\tearly\tchildhood\texposure\tto\tmicrobes\timpairs\tthe\tdevelopment\tof\timmune\tregulation\tand\toral\ntolerance.\tIt\tincorporates\ttwo\tearlier\tconcepts\treferred\tto\tas\tthe\t“hygiene\thypothesis”\n\tand\tthe\t“old | [
0.020029647275805473,
0.016098886728286743,
0.04292900487780571,
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0.06702138483524323,
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0.09620727598667145,
0.08397360146045685,
-0.04378912225365639,
0.026130616664886475,
0.038617... |
and\tthe\t“old\nfriends\thypothesis.”\tThese\thypotheses\tassume\tthat\timmune\tdysregulation\tis\tdue\tto\treduced\tmicrobial\nexposure\tand\ta\tlack\tof\tfecal\tmicrobial\tdiversity.\nThe\thygiene\thypothesis\twas\tproposed\tby\tDr.\tDavid\tStrachan\tin\t1989\tand\tposits\tthat\tthe\tincreasing | [
0.012655211612582207,
0.028375819325447083,
0.08507640659809113,
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0.030746974050998688,
0.04079166799783707,
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0.09214629977941513,
0.09472745656967163,
-0.058586250990629196,
0.021453777328133583,
0.0220... |
incidence\tof\tboth\tallergic\tand\tautoimmune\tdiseases\tcould\tbe\texplained\tby\ta\tlack\tof\tearly\tchildhood\nexposure\tto\tinfectious\tagents\twhich\tsuppressed\n\timmune\tsystem\tdevelopment.\tA\tprotective\teffect\tagainst\ndeveloping\tallergic\trhinitis\twas\tobserved\twith\tan\tincreasing\tnumber\tof\tsibling... | [
0.047072410583496094,
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0.00200029113329947,
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0.017507297918200493,
0.0936637744307518,
0.022427398711442947,
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0.10144397616386414,
0.1138686016201973,
-0.02625030092895031,
0.05922193452715874,
0.069791726... |
related\tto\tthe\tshared\texposure\tof\tcommon\tpathogens\ttransmitted\tthrough\tdirect\tcontact\twith\tother\nsiblings.\tHowever,\tthe\tInternational\tScientific\tForum\ton\tHome\tHygiene\t(IFH;\t\nhttps://www.ifh-\nhomehygiene.org\n)\tproposes\tthat\tthe\tterm\thygiene\n\thypothesis\tbe\tabandoned\tand\tinstead\treco... | [
0.0035679563879966736,
-0.004862988367676735,
0.032374702394008636,
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-0.0812036544084549,
0.02112131007015705,
0.01694859005510807,
-0.03930647671222687,
0.02776402235031128,
0.06312555074691772,
0.10263469815254211,
-0.030613506212830544,
0.0792214572429657,
-0.008167... |
hypothesis\tbe\tabandoned\tand\tinstead\trecommends\ta\n“targeted\thygiene”\tframework\tto\tmaximize\tprotection\tagainst\tpathogen\texposure\twhile\tallowing\tthe\nspread\tof\tessential\tmicrobes\tbetween\tfamily\tmembers\t(\nBloomfield\tet\tal,\t2016\n).\nThe\told\tfriends\thypothesis,\tproposed\tby\tDr.\tGraham\tRoo... | [
-0.011415146291255951,
0.008644239977002144,
0.05106645077466965,
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0.013364369049668312,
0.03374651446938515,
0.06309931725263596,
0.025295983999967575,
0.07095374912023544,
0.07271353155374527,
-0.014204653911292553,
0.0864362046122551,
-0.01410... |
present\tin\tprimate\tevolution\tand\thunter-gatherer\ttimes\twas\tvital\tto\tkeeping\n\tthe\thuman\timmune\tsystem\nin\tbalance\tand\tpreventing\toverreactions,\twhich\tis\tan\tunderlying\tcause\tof\tallergies.\tIt\tis\thypothesized\tthat\nanother\tprotective\teffect\tin\treducing\tthe\trisk\tof\tasthma\tand\tallergic... | [
0.005100196693092585,
0.01833467371761799,
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0.04508540406823158,
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0.11664213985204697,
0.07618748396635056,
-0.09376224875450134,
0.012163919396698475,
0.01975... |
environment\twith\texposure\tto\tpets\tand\tanimals\tversus\turban\tliving,\talthough\tresults\texamining\tthe\nrelationship\tbetween\tanimal\texposure\tand\tfood\tallergies\tare\tinconsistent.\n\tChanges\tin\tlifestyle\tand\nenvironment,\tsuch\tas\trapid\turbanization,\thighly\tprocessed\tdiet,\tand\texcessive\tantibi... | [
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0.10515505075454712,
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0.05357350409030914,
0.05388393625617027,
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0.045410700142383575,
0.0100... |
profound\teffects\tthat\tlikely\tcontribute\tto\tthe\tonset\tand\trise\tin\tallergic\tdisease\tdue\tto\timmune\tsystem\naberrations\tfrom\ta\tlack\tof\tearly\tmicrobial\texposure\tand\tdiversity.\tOther\tenvironmental\tfactors\ncontributing\tto\tthe\tmicrobial\texposure\thypothesis\tinclude\troute\tof\n\tdelivery\tat\t... | [
0.03069930151104927,
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0.09625297039747238,
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0.05417294055223465,
0.003461443819105625,
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0.09847960621118546,
0.0729893371462822,
-0.07207120209932327,
-0.017868151888251305,
0.0526... |
(\nBloomfield\tet\tal,\t2016\n).\nRoute\tof\tdelivery\nWhen\tan\tinfant\tis\tborn\tby\tcesarean\tdelivery,\tthe\tinfant\tis\tnot\texposed\tto\tthe\tmicrobial\twash\tof\tthe\nmother’s\tvagina.\tVaginally\tdelivered\tinfants\thave\tbacterial\tcommunities\treflecting\tthe\tmother’s\tvaginal | [
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0.028510702773928642,
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0.06083645671606064,
0.09046640247106552,
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... |
microbiota,\twhereas\tinfants\tborn\tby\tcesarean\tdelivery\thave\tbacterial\tcommunities\tsimilar\tto\tthose\tfound\non\tthe\n\tskin\t(\nDominguez-Bello\tet\tal,\t2010\n).\tStudies\texamining\tmode\tof\tdelivery\tand\trisk\tof\tfood\tallergy\nhave\tyielded\tconflicting\tresults,\talthough\tone\tsystematic\treview\tdid... | [
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0.0946568176150322,
0.1353062242269516,
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0.019708357751369476,
0.05198... |
increased\trisk\tof\tdeveloping\tfood\tallergy\tor\tfood\tsensitization\tin\tchildren\tdelivered\tby\tcesarean\tsection\n(\nMarrs\tet\tal.\t2013\n).\nAntibiotic\tuse\nIt\tis\twell\testablished\tthat\tantibiotics\tcan\tcause\tperturbations\n\tin\tthe\tgut\tmicrobiota.\tInfants\tcan\tbe | [
-0.007125165779143572,
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0.023563826456665993,
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0.07628320157527924,
0.1390381157398224,
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0.0018732581520453095,
0.0601... |
in\tthe\tgut\tmicrobiota.\tInfants\tcan\tbe\nexposed\tto\tantibiotics\tprenatally,\tat\tbirth,\tor\tpostnatally.\tSome\tinfants\tmay\thave\tmultiple\texposures\tover\ntime,\twhen\ttheir\tmicrobiome\tis\tstill\tbeing\tshaped.\tA\tlink\tbetween\tantibiotic\tuse\tin\tearly\tlife\tand\tfood | [
0.02112749218940735,
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0.031747136265039444,
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0.003308324608951807,
0.039431679993867874,
0.003414381295442581,
0.02431974932551384,
0.037988368421792984,
0.130082368850708,
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0.028130335733294487,
0.04821... |
allergies\thas\tbeen\tdemonstrated\talthough\tthe\trelationship,\tincluding\ttiming\tand\tfrequency\tof\texposure,\nneeds\tfurther\texploration\t(\nNASEM,\t2017\n).\nPrebiotics\tand\tprobiotics\nConsidering\tthe\timportance\tof\tthe\tmicrobiome\tin\timmune\tsystem\tregulation,\tthe\trole\tof\tprebiotics\tand | [
0.024546146392822266,
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0.08657363802194595,
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0.026875171810388565,
0.0999966636300087,
0.03168226778507233,
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0.05491900444030762,
0.08680882304906845,
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0.011879048310220242,
0.0523305... |
probiotics\tin\tallergy\tprevention\tcontinues\tto\tbe\tan\texploding\tarea\tof\tinvestigation.\tA\t\nprebiotic\n\tis\ta\nsubstrate\tthat\tis\tselectively\tutilized\tby\thost\tmicroorganisms\tconferring\ta\thealth\tbenefit\t(\nHill\tet\tal,\t2014\n).\nBreastmilk\tcontains\thuman\tmilk\toligosaccharides\t(HMO),\twhich\n... | [
-0.018367920070886612,
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0.0298539400100708,
0.003730041440576315,
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0.02736949361860752,
0.06549367308616638,
0.024232741445302963,
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0.06006709113717079,
0.12057483196258545,
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0.03006431832909584,
0.02120221... |
are\tnondigestible\tcarbohydrates\twith\nprebiotic\tproperties\tthat\tprovide\tthe\tsubstrate\tfor\tspecific\tearly\tmicrobial\tcolonization.\tPrebiotics\thave\nbeen\tadded\tto\tinfant\tformulas,\twhich\twere\tpreviously\tdevoid\tof\toligosaccharides,\tas\tthey\tmay\tdecrease\nthe\tincidence\tof\tatopic\tdermatitis.\tT... | [
0.022098448127508163,
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0.05087538808584213,
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0.026250705122947693,
0.04989628121256828,
0.040109775960445404,
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0.07210057228803635,
0.06591375172138214,
-0.04030952975153923,
0.05149433761835098,
0.07611... |
Heine,\t2018\n).\nProbiotics\n\tare\tlive\tmicroorganisms\tthat,\twhen\n\tadministered\tin\tadequate\tamounts,\tconfer\ta\thealth\nbenefit\ton\tthe\thost\t(\nHill\tet\tal,\t2014\n).\tInfants\twith\tallergies\thave\tbeen\tshown\tto\thave\ta\tmicrobial\ncomposition\twith\tlower\tnumbers\tof\t\nBifidobacteria\n\tcompared\... | [
0.004933612886816263,
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0.03553365170955658,
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0.0515030138194561,
0.012926449999213219,
0.04279031604528427,
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0.09304936230182648,
0.09861636161804199,
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0.049007341265678406,
0.07737... |
Bifidobacteria\n\tcompared\twith\thealthy\tinfants\t(\nHeine,\t2018\n).\tThe\nadministration\tof\tprobiotics\tin\tthe\tlast\tweeks\tof\tpregnancy\tand\tto\tinfants\tduring\tthe\tfirst\tfew\tmonths\tof\nlife\tis\tassociated\twith\ta\tsignificant\treduction\n\tin\tatopic\teczema.\tHowever,\tthe\teffect\tof\tthe\tindividu... | [
0.0025814282707870007,
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0.052193399518728256,
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0.058079928159713745,
0.04015393555164337,
0.030776847153902054,
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0.08495058864355087,
0.12524069845676422,
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0.009707663208246231,
0.024... |
in\tatopic\teczema.\tHowever,\tthe\teffect\tof\tthe\tindividual\nprobiotic\tstrain,\tdose,\ttiming,\tfood\tmatrix,\tand\tenvironmental\tfactors\tthat\taffect\tcolonization\tneed\tto\tbe\nexplored\tfurther\tsince\tresults\thave\tbeen\tvaried\t(\nInternational\tScientific\tAssociation\tfor\tProbiotics\tand\nPrebiotics,\t... | [
0.043047476559877396,
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0.00741209089756012,
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0.023711204528808594,
0.020058799535036087,
0.008284909650683403,
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0.06113464757800102,
0.10302611440420151,
-0.0469537191092968,
0.005868807900696993,
0.06371... |
Prebiotics,\t2016\n).\nThe\tSynergy\tin\tMicrobiota\tResearch\t(SyMBIOTA)\tproject\tis\tone\tof\tthe\tlargest\tinfant\tmicrobiome\nstudies\tin\tthe\n\tworld\t(\nCHILD\tstudy,\t2018\n).\tIt\texamines\trelationships\tbetween\tthe\tinfant\tmicrobiome\tand\nvariations\tin\tthis\tinternal\tecosystem\tsuch\tas\tantibiotic\tu... | [
-0.003400188172236085,
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0.012613429687917233,
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0.015281868167221546,
0.039539068937301636,
0.002213503001257777,
0.07499337196350098,
0.14144879579544067,
-0.06993842869997025,
0.013553106226027012,
0.060... |
affect\thealth\tand\tdisease\t(\nKozyrskyj,\t2015\n;\t\nNASEM,\t2017\n).\tThe\tdata\tsuggest\tthat\tlower\tspecies\trichness\nin\tmicrobiota\tof\tinfants\tmight\tbe\ta\tpredictor\tof\tfood\tsensitization\t(i.e.,\tmilk,\tegg,\tpeanut)\teven\n\twhen\nadjustments\tfor\tdelivery\tmode,\tantibiotic\tuse,\tand\tbreastfeeding... | [
0.004332531243562698,
0.008204234763979912,
0.03641894832253456,
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0.04863276705145836,
0.06248803064227104,
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0.059863973408937454,
0.08895339071750641,
-0.01434137299656868,
0.05874893441796303,
0.06210405... |
Azad\tet\tal,\t2015\n).\tThey\nalso\tfound\tthat\tsensitization\toccurred\tafter\tchanges\tin\tmicrobiota\tdiversity\tand\trichness\tand\tthat\tthis\nratio\tcould\tbe\ta\tpotential\tpredictor\tof\tfood\tsensitization.\nAllergen\tavoidance\thypothesis\nAllergen\texposure\tat\tconception\tand\tduring\tpregnancy\tand\tlac... | [
0.013103080913424492,
-0.013791426084935665,
0.021980302408337593,
-0.0077856676653027534,
-0.0683140829205513,
0.029062451794743538,
0.09853015840053558,
0.009639665484428406,
0.013158110901713371,
0.08670509606599808,
0.11753526329994202,
-0.03926132619380951,
0.05055135861039162,
0.0201... |
of\tresearch\nsince\tthis\tis\tthe\ttime\tof\tthe\torigin\tof\tthe\tinfant’s\timmune\tsystem\tdevelopment.\tMaternal\tdiet\tduring\npregnancy\tand\tlactation\thas\ta\tprofound\tinfluence\ton\tthe\tchild’s\thealth\t(\nVenter\tet\tal,\t2017\n).\tAvoidance\tof\nallergenic\tfoods\tduring\tpregnancy\tand\tthe\tearly\tpostna... | [
0.0209111999720335,
-0.02467542141675949,
0.06589587032794952,
-0.021116428077220917,
-0.08466070890426636,
0.04930413141846657,
0.07089565694332123,
0.01374933309853077,
0.005198011174798012,
0.10344219207763672,
0.15332981944084167,
-0.05720836669206619,
0.03525041043758392,
-0.000728431... |
prevention.\tHowever,\thigh-quality\tstudies\ton\tmaternal\tdiets\tconclude\tthat\n\tthe\tevidence\tis\tnot\tstrong\nenough\tto\trecommend\tchanging\tthe\tdiet\tof\tpregnant\tand\tbreastfeeding\twomen\tto\tprevent\tfood\tallergies\nin\tinfants\tat\tnormal\tor\thigh\trisk\tof\tfood\tallergies\t(\nNASEM,\t2017\n).\tThus\... | [
0.025719398632645607,
0.00343940663151443,
0.09559669345617294,
-0.04281206056475639,
-0.08542501926422119,
0.018067272379994392,
0.07516606152057648,
0.0066786715760827065,
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0.1137833520770073,
0.1300908923149109,
-0.029862694442272186,
0.017778899520635605,
-0.016793... |
NASEM,\t2017\n).\tThus\telimination\tdiets\tduring\npregnancy\tand\tlactation\tfor\tthe\tpurpose\tof\tallergy\tprevention\tare\tnot\twarranted.\nBreastfeeding\nBreastfeeding\tis\tone\tof\tthe\tmain\tinfluences\ton\tthe\tinfant\tgut\tmicrobiota\n\tdevelopment.\tHuman\tmilk\tis\ta\nnutritional\tmatrix\twith\ta\thost\tof\... | [
0.019349370151758194,
-0.016027159988880157,
0.032406143844127655,
-0.02201135829091072,
-0.07205314934253693,
0.029513483867049217,
-0.0019683961290866137,
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0.10349701344966888,
0.15074968338012695,
-0.0636506900191307,
-0.002793618943542242,
0.0... |
that\timpact\timmune\tresponses.\tThere\tare\tmany\twell-documented\tbenefits\tof\tbreastfeeding\tincluding\nprotection\tagainst\tinfections,\tobesity,\tand\tchronic\tdiseases,\tand\tit\tis\tassociated\twith\ta\tfecal\tmicrobiota\nhigh\tin\tbeneficial\t\nBifidobacteria\n.\tMany\tstudies\thave\texamined\n\tthe\tassociat... | [
0.034854989498853683,
-0.04437623545527458,
0.07802076637744904,
-0.0060651120729744434,
-0.07510670274496078,
0.026151251047849655,
0.0865151435136795,
-0.007238074671477079,
0.010252024047076702,
0.10061720758676529,
0.08705060929059982,
-0.09240793436765671,
0.019879251718521118,
0.0430... |
the\tassociation\tbetween\tbreastfeeding\tand\nthe\tdevelopment\tof\tfood\tallergy\tand\tthe\tdata\tis\tinconsistent.\tInfants\twho\tare\texclusively\tbreastfed\tcan\nexpress\tclinical\tmanifestations\tof\tfood\tallergy,\tincluding\tFPIES\tas\talready\tdescribed,\tand\tmultiple\tfood\nintolerances\tof\tinfancy\t(\nHein... | [
0.0366375707089901,
-0.05351041257381439,
0.07486539334058762,
-0.011692279018461704,
-0.07336818426847458,
0.020947521552443504,
0.0882541760802269,
-0.015300840139389038,
0.012041204608976841,
0.09194490313529968,
0.13965991139411926,
-0.07076115161180496,
0.0022083777002990246,
0.036939... |
intolerances\tof\tinfancy\t(\nHeine,\t2018\n).\tThe\tuse\tof\ta\thypoallergenic\tmaternal\telimination\tdiet\tthat\neliminates\tallergens\tsuch\tas\tcow’s\tmilk\tcan\tbe\n\thelpful\tif\tallergic\tsymptoms\tare\tpresent\tin\tthe\tinfant.\nHowever,\tmaternal\tdietary\trestrictions\tduring\tpregnancy\tand\tlactation\tfor\... | [
0.030234139412641525,
-0.022633476182818413,
0.07553841173648834,
-0.01921546645462513,
-0.08926432579755783,
0.025406507775187492,
0.061986666172742844,
0.02787807770073414,
0.006474684923887253,
0.08717844635248184,
0.11547393351793289,
-0.03727254644036293,
0.01491941325366497,
0.005849... |
prevention\tare\tnot\trecommended\t(\nHeine,\t2018\n).\tThe\texact\trole\tof\tbreastfeeding\tin\tallergy\tprevention\nremains\tunclear,\tand\tit\tappears\tthat\tit\tmay\tnot\treliably\tconfer\ta\tprotective\teffect\tagainst\tfood\tallergies,\nalthough\tmore\tresearch\tis\tneeded.\n\tAt\tleast\t6\tmonths\tof\texclusive\... | [
0.007201093249022961,
0.0038680066354572773,
0.0776347666978836,
-0.037904541939496994,
-0.024567753076553345,
0.06749923527240753,
0.056643854826688766,
0.031740520149469376,
-0.0276613961905241,
0.06762035191059113,
0.11901521682739258,
0.0022976058535277843,
0.0749049037694931,
0.016268... |
At\tleast\t6\tmonths\tof\texclusive\tbreastfeeding\tis\trecommended\tfor\tall\ninfants\tregardless\tof\tfamily\tallergy\trisk\t(see\t\nBox\t25.9\n).\nInfant\tformulas\nThe\tuse\tof\tinfant\tformulas\tto\tprevent\tallergy\tin\thigh-risk\tinfants\twho\tare\tunable\tto\texclusively\tbreastfeed | [
0.014280642382800579,
-0.036975957453250885,
0.03236730396747589,
-0.030602728947997093,
-0.06614350527524948,
0.04559827595949173,
-0.008632052689790726,
0.05502944812178612,
-0.008475509472191334,
0.05157744884490967,
0.09607964754104614,
-0.03993822634220123,
0.02996467426419258,
-0.015... |
is\tbeing\texplored.\tA\tsystematic\treview\tand\tmeta-analysis\twas\tconducted\tby\tBoyle\tet\tal.\tto\tdetermine\nwhether\tuse\tof\ta\thydrolyzed\tformula\treduces\n\tthe\trisk\tof\tallergic\tdisease\tin\thigh-risk\tinfants\t(\nBoyle\tet\tal,\n2016\n).\tTheir\tconclusion,\talong\twith\tother\tsystematic\treviews,\tfo... | [
0.023415036499500275,
-0.039739906787872314,
0.03535732626914978,
-0.04289654269814491,
-0.06705468147993088,
-0.009511679410934448,
0.06400049477815628,
0.026522304862737656,
-0.02614036574959755,
0.07229400426149368,
0.08441472053527832,
-0.023352935910224915,
0.03091205470263958,
0.0421... |
to\tsupport\tthe\tuse\tof\thydrolyzed\tcow’s\tmilk\tformulas—partially\thydrolyzed\tformulas\t(PHF)\tor\tEHF—over\nbreastmilk\tfor\tthe\tprevention\tof\tfood\tallergy\tand\tfood\tsensitization.\tIn\taddition,\tthe\tevidence\tis\tnot\nstrong\tenough\tto\tconclude\n\tthat\thydrolyzed\tformulas\treduce\tthe\trisk\tof\tfoo... | [
-0.026716649532318115,
-0.029851876199245453,
0.045380689203739166,
-0.037265896797180176,
-0.05181487649679184,
0.011203144676983356,
0.039718806743621826,
0.01492451410740614,
0.019970959052443504,
0.06543079763650894,
0.12465094774961472,
-0.01274534035474062,
0.034503135830163956,
-0.0... |
compared\twith\tstandard\tformulas\t(\nNASEM,\t2017\n).\nDual\tallergen\thypothesis\nThe\t\ndual\tallergen\thypothesis\n\tproposes\tthat\tallergic\tsensitization\tto\tfoods\tmay\toccur\tfrom\ta\tdisrupted\nskin\tbarrier\tearly\tin\tlife,\tas\toccurs\tin\tinfantile\teczema.\tThe\tloss\tof\tskin\tbarrier\tintegrity\tincr... | [
0.020835474133491516,
-0.012497496791183949,
0.04336144030094147,
-0.07137075811624527,
-0.10028694570064545,
-0.000765609263908118,
-0.01920308545231819,
0.014812405221164227,
-0.00822387170046568,
0.07384002208709717,
0.10152549296617508,
-0.04635230824351311,
0.04691183567047119,
0.0279... |
environmental\texposure\tto\tlow\tdoses\n\tof\tfood\tallergens\tthrough\tthe\tskin.\tData\tsuggests\tthat\tloss\tof\nfunction\tof\tfilaggrin,\ta\tprotein\timportant\tfor\tepithelial\tstructure,\talong\twith\ta\tcompromised\tskin\tbarrier,\nincreases\tthe\trisk\tfor\tfood\tsensitization\tfrom\tthe\tenvironment\t(\nRenz\... | [
0.028729038313031197,
-0.027755776420235634,
0.022294018417596817,
-0.05230952054262161,
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0.06797432154417038,
0.007547320332378149,
-0.0025889223907142878,
0.08507511019706726,
0.103003591299057,
-0.08582468330860138,
0.0525650680065155,
0.02920... |
Renz\tet\tal,\t2018\n).\nThe\thypothesis\talso\tpostulates\tthat\toral\texposure\tto\tthese\tsame\tallergens\tthrough\tconsumption\tof\tthe\nallergenic\tfoods\tearly\tin\tlife\tleads\tto\n\toral\ttolerance\tand\tprevents\tthe\tdevelopment\tof\tsensitization\tand\nallergy\teven\twith\tsubsequent\texposures\t(\nRenz\tet\... | [
-0.02695591188967228,
0.026241380721330643,
0.08300592750310898,
-0.04960693418979645,
-0.06344044953584671,
0.0407709926366806,
0.05010088533163071,
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0.010327586904168129,
0.1055247113108635,
0.10777771472930908,
-0.01616821065545082,
0.04703587293624878,
0.01827947981... |
Renz\tet\tal,\t2018\n).\tThis\thypothesis\tis\talso\tthought\tto\texplain\tthe\n“atopic\tmarch,”\n\ta\tpattern\tthat\tdescribes\ta\tprocess\tin\twhich\tatopic\tdisorders\tprogress\tover\ttime\tfrom\neczema\t(i.e.,\tatopic\tdermatitis)\tto\tasthma\tto\tmultiple\tallergic\tdisorders\tincluding\tfood\tallergy\t(\nNASEM,\n... | [
-0.020017972216010094,
0.0022921827621757984,
0.07549042999744415,
-0.0666990801692009,
-0.08785168081521988,
-0.0001877935865195468,
0.058037176728248596,
-0.0009082044125534594,
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0.07728509604930878,
0.1063590720295906,
-0.0479578822851181,
0.050613049417734146,
0.00... |
NASEM,\n2017\n).\nThe\tdual\tallergen\n\thypothesis\twas\tborn\tout\tof\tthe\tobservation\tthat\tinfants\twith\teczema\thave\ta\thigh\trisk\nof\tdeveloping\tIgE-mediated\tfood\tallergies.\tSupporting\tthis\thypothesis\tare\tdata\tsuggesting\tthat\tearly\ndietary\tintroduction\tof\tpeanut\tproducts\tmay\tconfer\tprotect... | [
0.006613580975681543,
0.010821918025612831,
0.09594862163066864,
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0.037593428045511246,
0.045541901141405106,
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0.11563125997781754,
0.10246384143829346,
-0.029697775840759277,
0.024023553356528282,
-0.00... |
However,\tmany\tquestions\tremain\tabout\tthe\tmechanisms\tby\twhich\tsensitization\tand\ttolerance\toccur,\nand\tabout\tthe\telements\tof\tthe\n\timmune\tsystem\tthat\trepresent\tthe\tmost\timportant\tcontributors\tto\tthe\nseverity\tof\tfood\tallergy\tor\tthe\testablishment\tof\ttolerance.\nTiming\tof\tintroduction\t... | [
0.057020653039216995,
-0.038500603288412094,
0.04604119062423706,
-0.058599866926670074,
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0.05264630913734436,
-0.021985407918691635,
0.014799281023442745,
0.09119229018688202,
0.1017991304397583,
-0.020065059885382652,
0.05170038715004921,
0.0352... |
Timing\tof\tintroduction\tof\tsolids\tand\tinfant\tfeeding\nEarlier\tfood\tallergy\tprevention\tstrategies\trecommended\tdelayed\tintroduction\tof\tcommon\tallergenic\tfoods\ninto\tthe\tinfant’s\tdiet.\tThere\tis\tnow\tdirect\tevidence\tfrom\trandomized\tcontrolled\ttrials\tthat\tthe\tparadigm\tis\nshifting\n\tfrom\tav... | [
0.006433154921978712,
-0.05795513838529587,
0.0560271181166172,
-0.02852887287735939,
-0.06947550922632217,
0.0024252207949757576,
0.042132794857025146,
0.00960545614361763,
0.015699129551649094,
0.04748644679784775,
0.11724138259887695,
-0.061444249004125595,
0.03633951395750046,
-0.00020... |
shifting\n\tfrom\tavoidance\tto\tcontrolled\texposure\t(\nWest,\t2017\n).\tAlthough\tthe\t“optimal”\tperiod\tfor\nintroduction\tof\tcomplementary\tfoods\tfor\tallergy\tprevention\tis\tnot\tknown,\ta\t“window\tperiod”\tbetween\t4\tto\n6\tmonths\tof\tage\twhen\tsolids\tare\tintroduced\tis\trecommended\tby\tmost\tinternat... | [
-0.021903574466705322,
-0.02761066146194935,
0.04396564140915871,
-0.06505532562732697,
-0.05995054915547371,
0.00888131745159626,
0.031887784600257874,
0.0029335087165236473,
0.025229046121239662,
0.05823862925171852,
0.0743037760257721,
0.0009401130955666304,
0.060531165450811386,
0.0122... |
induction\tof\ttolerance\t(\nHeine,\t2018\n;\t\nWest,\t2017\n).\tThe\tAustralian\tHealthNuts\tstudy,\tthe\tLearning\tEarly\nAbout\n\tPeanut\t(LEAP),\tand\tEnquiring\tAbout\tTolerance\t(EAT)\tare\tsome\tof\tthe\tkey\tstudies\tthat\tassess\tearly\nversus\tlate\tintroduction\tof\tcomplementary\tfoods\tfor\tallergy\tpreven... | [
0.012025576084852219,
-0.027987152338027954,
0.06305759400129318,
-0.012283780612051487,
-0.07840517163276672,
0.028517302125692368,
0.04642783850431442,
-0.006094774696975946,
-0.002004855079576373,
0.08969482779502869,
0.12114285677671432,
-0.02382299304008484,
0.04851637780666351,
0.005... |
timing\tof\tthe\tdietary\tintroduction\tof\tfood\tallergens\tin\thigh-risk\tinfants\t(\nFleischer\tet\tal,\t2015\n;\t\nHeine,\n2018\n;\t\nWest,\t2017\n;\t\nDuToit\tet\tal,\t2015\n)\t(see\t\nBox\t25.9\n).\nThe\tpivotal\tLEAP\ttrial\tprovides\tstrong\n\tevidence\tthat\tearly\tintroduction\tof\tpeanuts\t(from\t4\tto\t11\t... | [
-0.01635121740400791,
-0.02529209852218628,
0.054089341312646866,
-0.04416681081056595,
-0.05965045467019081,
0.05078321322798729,
0.050025030970573425,
0.01981867104768753,
0.016506971791386604,
0.03482065722346306,
0.09602439403533936,
-0.022870035842061043,
0.0302635058760643,
0.0015891... |
evidence\tthat\tearly\tintroduction\tof\tpeanuts\t(from\t4\tto\t11\tmonths\nof\tage)\tincreases\tprotection\tagainst\tpeanut\tallergy\tin\tinfants\twho\tare\tat\thigh\trisk\t(defined\tby\tearly-onset\neczema\tand/or\tegg\tallergy)\t(\nNASEM,\t2017\n;\t\nWest,\t2017\n;\t\nHeine,\t2018\n;\t\nTogias\tet\tal,\t2017\n). | [
-0.03898818790912628,
0.03587695583701134,
0.1171967014670372,
-0.055315978825092316,
0.000590199779253453,
0.052943743765354156,
0.019402742385864258,
0.033290036022663116,
-0.011958478949964046,
0.12159445136785507,
0.10219749808311462,
-0.05606852471828461,
0.0006240357761271298,
0.0353... |
NASEM,\t2017\n;\t\nWest,\t2017\n;\t\nHeine,\t2018\n;\t\nTogias\tet\tal,\t2017\n).\nThe\trole\tof\tdiet\tdiversity\tin\tearly\tlife\tfeeding\tpractices\tmay\tbe\tanother\tinfluential\tfactor\tin\tfood\tallergy\nprevention.\tIncreased\tdiversity\n\tof\tcomplementary\tfoods,\tincreased\tvegetables\tand\tfruit,\tand\tmore\... | [
0.021164605394005775,
-0.02400672622025013,
0.0533127635717392,
0.013603156432509422,
-0.07349810749292374,
0.021397406235337257,
0.06161612272262573,
-0.009304995648562908,
-0.02701869234442711,
0.03800986334681511,
0.13864289224147797,
-0.04579690843820572,
0.028477633371949196,
-0.01048... |
prepared\tmeals\tin\tthe\tfirst\tyear\tof\tlife\thave\tbeen\tassociated\twith\ta\treduced\trisk\tof\tfood\tallergy\t(\nNASEM,\n2017\n;\t\nDu\tToit\tet\tal,\t2018\n).\nMany\tquestions\tremain\ton\tthe\tbest\tstrategies\tto\toptimize\tinfant\tfeeding\tregimens\tand\tsupport\tthe\tmost\nfavorable\t“tolerogenic”\tmicroenvi... | [
0.018435265868902206,
0.0066110254265367985,
0.028621969744563103,
-0.017928538843989372,
-0.08366307616233826,
-0.007395455613732338,
0.0035229779314249754,
-0.0071116420440375805,
-0.028266064822673798,
0.07352635264396667,
0.12541767954826355,
-0.0818842425942421,
0.08689562231302261,
-... |
since\tthe\timmunomodulatory\tcapacity\tof\tthe\tGI\ttract\tis\tinfluenced\tby\tmultiple\tfactors\t(\nWest,\t2017\n;\t\nRenz\net\tal,\t2017\n).\nNutritional\timmunomodulation\nA\tbalanced\timmune\tsystem\tis\tessential\tto\thealth,\tand\tnutrition\tis\ta\tmajor\tfactor\tthat\timpacts\nimmunocompetence.\tThe\timmunoregu... | [
0.032606735825538635,
-0.022727081552147865,
0.08808410912752151,
-0.013014919124543667,
-0.12253201007843018,
0.07094281911849976,
0.07741430401802063,
-0.01417656522244215,
-0.009087768383324146,
0.09571415185928345,
0.12499555200338364,
-0.07993749529123306,
0.010422002524137497,
0.0492... |
vitamin\tD,\tfolate,\tand\tomega-3\tfatty\tacids,\tand\tis\tinfluenced\n\tnot\tonly\tby\tdietary\tintake\tbut\talso\tby\ndigestive\tdynamics\tand\tmicrobial\tinterplay.\nVitamin\tD\nVitamin\tD\thas\treceived\tincreased\trecognition\tfor\tits\trole\tin\timmune\tregulation,\tas\tseveral\tstudies\thave | [
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0.05153178796172142,
0.07052292674779892,
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-0.02216688171029091,
-0.008... |
provided\tevidence\tthat\tvitamin\tD\tdeficiency\tis\tassociated\twith\tfood\tallergy.\tEvidence\tsuggests\tvitamin\tD\nhelps\tpromote\timmunoregulation\tthrough\tinduction\tof\tT\nreg\n\tcells\tand\tT-cell\tdifferentiation.\n\tA\tshift\tto\tTh2\nresponses\toccurs\twith\tlow\tor\tvitamin\tD–deficient\tconditions\t(\nRe... | [
-0.0050730942748487,
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0.04757087677717209,
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0.09825246036052704,
0.1288882941007614,
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0.018362058326601982,
0.06316068... |
Renz\tet\tal,\t2018\n).\tA\tfew\tstudies\thave\talso\nexamined\tthe\teffect\tof\tmaternal\tvitamin\tD\tstatus,\tcord\tblood,\t25(OH)D\n3\n\tlevels,\tand\tthe\tdevelopment\tof\nfood\tallergy,\twith\tconflicting\treports.\tMultiple\tgenes\tare\tinvolved\tin\tvitamin\tD\tmetabolism\tand\tregulatory\npathways,\tand\tfuture... | [
0.004540093708783388,
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0.08867552876472473,
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0.009108689613640308,
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0.10315451771020889,
0.1319401115179062,
-0.03056180477142334,
0.032455991953611374,
0.0500379... |
pathways,\tand\tfuture\tstudies\tthat\tconsider\tgenetic\tpolymorphisms\twill\n\thelp\tclarify\tthe\trelationship\nbetween\tvitamin\tD\tand\tfood\tallergy\t(\nJones\tet\tal,\t2015\n;\t\nNASEM,\t2017\n).\nFatty\tacids\nThe\trole\tof\tdietary\tfats\tin\tallergy\tdevelopment\thas\tbeen\tthe\tsubject\tof\tinvestigation,\tw... | [
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0.09093338996171951,
0.14931075274944305,
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0.04... |
fatty\tacids\tbeing\tthe\tmost\textensively\tstudied.\tThe\tamount\tof\tomega\t3-fatty\tacids\tin\tthe\tU.S.\tdiet\thas\ndecreased\tover\ttime\talong\twith\ta\tcorresponding\tincrease\tin\tomega-6\tfatty\tacids\n\tintake,\tand\tthis\nimbalance\tis\tthought\tto\tbe\ta\tcritical\tnutrition\tfactor\tin\tthe\tprevalence\to... | [
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0.04194100946187973,
0.11458445340394974,
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0.018369993194937706,
0.005... |
allergic\tdisorders\t(\nHeine,\t2018\n).\nOmega-3\tfatty\tacids\thave\tantiinflammatory\tand\timmunomodulatory\teffects.\tSome\tstudies\tsuggest\tthat\nmaternal\tconsumption\tof\tfish\toil\t(a\tsource\tof\tomega-3\tfatty\tacids)\tin\tpregnancy\tprotects\tagainst\tthe\ndevelopment\tof\tasthma,\teczema,\tand\tallergic\n\... | [
-0.01486150175333023,
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0.037441596388816833,
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0.03663426637649536,
0.11014015972614288,
0.058776240795850754,
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0.077559694647789,
0.11369156092405319,
-0.07212111353874207,
0.0305382888764143,
0.0417106... |
sensitization\tin\tthe\tinfant,\twhereas\tothers\tdo\tnot\tshow\nthese\tresults\t(\nPalmer\tet\tal,\t2013\n).\tControversy\tand\tquestions\tremain\tregarding\tthe\trelationship\tbetween\nomega-3\tfatty\tacid\tcontent\tof\tthe\tmaternal\tdiet\tand\twhether\tthis\tconfers\ta\tprotective\teffect\tagainst | [
0.007476337719708681,
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0.053238701075315475,
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0.05148763209581375,
0.12215478718280792,
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0.04422777146100998,
0.033105... |
development\tof\tchildhood\tfood\tallergy.\tFurther\tstudies\tare\tneeded\tto\telucidate\tthe\trole\tof\tfatty\tacids\tin | [
0.019213002175092697,
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0.09515390545129776,
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allergy\tprevention\tand\ttheir\n\trole\tin\tthe\tinflammatory\tcascade\t(see\t\nChapter\t7\n).\nFolate\nThere\tis\trenewed\tinterest\tin\tfolate\tas\ta\tdietary\tmethyl\tdonor\tthat\talters\tgene\texpression\tand\timpacts\nimmune\tfunction\tthrough\tepigenetic\tmechanisms\t(\nBrown\tet\tal,\t2014\n).\tFolate\texposure... | [
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0.10485627502202988,
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0.021224306896328926,
0.03967049... |
Brown\tet\tal,\t2014\n).\tFolate\texposure\tin\tutero\tcan\taffect\nDNA\tmethylation\tduring\tfetal\tdevelopment\tand\tinfluence\ttranscriptional\tactivity\tand\tmay\tbe\tinvolved\tin\nT-cell\tdifferentiation.\tMost\n\tstudies\tto\tdate\thave\tfocused\ton\tasthma,\twith\ta\tvery\tlimited\tnumber\texamining | [
0.0017803461523726583,
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0.... |
the\trelationship\tof\tfolate\tto\tfood\tallergy\tand\tfood\tsensitization.\tThe\tsignificant\trole\tthat\tfolate\tplays\tin\nmethylation\tof\tkey\tregulatory\tgenes\tand\tits\tpotential\tin\tallergic\tpredisposition\twarrants\tfurther\ninvestigation.\nOther\tnutrients\nFew\tstudies\thave\texamined\tthe\trelationship\t... | [
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0.00012150451220804825,
-0.002... |
intake\t(beta-carotene,\nvitamins\tC\tand\tE,\tcopper,\tand\tzinc)\tduring\tpregnancy\tand\tthe\trisk\tof\tdeveloping\tfood\tallergy.\tIn\taddition,\nnutrient\tassessment\tof\tindividuals\twith\tfood\tallergies\tand\tintolerances\thas\tnot\tbeen\tthoroughly\texamined\nin\tresearch\tand\tis\tan\tavenue\tripe\tfor\texplo... | [
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NASEM,\t2017\n).\nFuture\tdirections\nThere\tare\ta\tnumber\tof\tareas\tthat\tare\tbeing\tintensely\tstudied\tas\tpotential\n\ttherapeutics\tfor\tfood\tallergy.\nImmunotherapy\nThe\tconcept\tof\t\nallergen\timmunotherapy\t(AIT)\n,\twhich\taims\tto\tprovide\tdesensitization\tin\ta\tsystematic | [
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0.08870494365692139,
0.0874330922961235,
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0.05694... |
,\twhich\taims\tto\tprovide\tdesensitization\tin\ta\tsystematic\nstepwise\tprocess,\twas\tfirst\tdescribed\tin\tthe\tearly\t1900s.\tIt\tis\ta\tprocedure\tinducing\ttolerance\tto\ta\tspecific\nallergen\tby\trepetitive\tadministration\tof\tsmall\tamounts\tof\tan\tallergen,\tand\tit\thas\tbeen\teffective\tin\nrespiratory\... | [
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0.089197538793087,
0.10636771470308304,
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0.05448409169912338,
0.05380535870... |
respiratory\tallergy\tand\tvenom\thypersensitivity.\n\tThree\tmain\tclinical\timmunotherapy\tconcepts\thave\nemerged\tsince\tthen,\tincluding\toral\timmune\ttherapy\t(OIT),\tsublingual\timmune\ttherapy\t(SLIT)\tand\nepicutaneous\timmunotherapy\t(EPIT).\tOngoing\tstudies\tof\tthese\tmethods\thave\tidentified\tbenefits\t... | [
-0.009717842563986778,
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0.08649229258298874,
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0.10449907183647156,
0.10455086827278137,
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0.020021114498376846,
0.04587... |
limitations\tof\teach,\tincluding\tside\teffects\tand\tadverse\treactions.\nThe\teffectiveness\tof\tthe\ttherapies\tin\tfood\tallergy\tremains\tunder\tinvestigation,\tincluding\n\tthe\tpotential\tof\ncombination\ttherapies\tsuch\tas\tOIT\tplus\timmune\tmodulation\twith\tprobiotics\tor\ttraditional\tChinese\nmedicine\t(... | [
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0.05298972874879837,
0.0722949206829071,
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0.028184112161397934,
0.0658152... |
medicine\t(\nSicherer\tand\tSampson,\t2018\n).\tA\tgrowing\tbody\tof\tevidence\tsupports\tthe\tuse\tof\tAIT\tfor\tsubsets\nof\tpatients\twith\tfood\tallergies;\thowever,\tbiomarkers\tthat\tare\tpredictive\tof\tfavorable\toutcomes\tand\nstrategies\tto\timprove\tthe\tsafety\tand\tefficacy\tof\tAIT\tare\tneeded\t(\nFeuill... | [
0.027348089963197708,
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0.05815330520272255,
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0.03265135735273361,
0.08944785594940186,
0.035283204168081284,
0.02682649716734886,
0.022100206464529037,
0.0908619612455368,
-0.014221983030438423,
0.05423809587955475,
0.0270300... |
Feuille\tand\tNowak-Węgrzyn,\t2018\n).\nGenetics\tand\tomics\nThe\tpotential\tof\tgenetic\tdata\tand\t“omics”\ttechnologies\tsuch\tas\tepigenomics,\tproteomics,\ttranscriptomics,\nmetabolomics,\tmicrobiomics,\tand\texposomics\tis\tnow\tbeing\trecognized\t(see\t\nChapter\t6\n).\tFor\texample, | [
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0.012062719091773033,
0.05551797151565552,
-0.001240766723640263,
-0.051262784749269485,
0... |
Chapter\t6\n).\tFor\texample,\nmetabolomics\tcan\tprovide\tdata\ton\tthe\tmetabolic\tpathway\tactivity\tassociated\twith\tegg\tand\tpeanut\tallergy,\nwhereas\tmicrobiomics\tcan\tidentify\tmicrobial\trisk\tfactors\tthat\tare\n\tinfluencing\tgut\tphysiology.\tOther\n“omics”\tapproaches\tcan\tprovide\tmeasurements\tof\tpr... | [
-0.006047703791409731,
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0.012017796747386456,
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0.04423058032989502,
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0.06857556104660034,
0.1034918799996376,
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0.011452329345047474,
0.016... |
and\tenvironmental\texposures\t(exposomics)\tcontributing\tto\tfood\tallergy\tprevalence.\tData\tderived\tfrom\n“omics”\tapproaches\twill\tprovide\trobust\tsets\tof\tbiological\tand\tenvironmental\tdata\tthat\twill\tbe\tused\tto\nbetter\tinform\tour\tunderstanding\tof\tfood\tallergy,\tand\topen\tnew\tavenues\n\tfor\tbo... | [
0.04212581738829613,
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0.07534471899271011,
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0.07146397233009338,
0.09917096793651581,
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0.02999490685760975,
0.00800971... |
for\tboth\tthe\tprevention\tand\ntreatment\tof\tthis\tdisease\t(\nDhondalay\tet\tal,\t2018\n).\nFuture\tinnovations\nInnovative\tapproaches\tsuch\tas\tmodification\tof\trelevant\tfood\tallergens\t(to\tmake\tthem\tless\tallergenic\twhile\nmaintaining\ttheir\timmunogenicity)\tor\tcombining\tother\ttherapies\t(e.g.,\tprob... | [
0.006027265917509794,
-0.05482548847794533,
0.039288267493247986,
-0.013889990746974945,
-0.06812065839767456,
0.02745766192674637,
0.05926577374339104,
0.05093097686767578,
-0.0047129373997449875,
0.052323587238788605,
0.12654735147953033,
-0.02899055741727352,
0.02209465764462948,
0.0369... |
food\tchallenges)\tto\tincrease\tefficacy\tand/or\tsafety\twill\tcontinue\tto\tdominate\tthe\tfood\n\tallergy\tlandscape\n(\nNeerven\tand\tSavelkoul,\t2017\n).\nUseful\twebsites\nAllergy\tAware\tCanada\nAmerican\tAcademy\tof\tAllergy,\tAsthma\tand\tImmunology\nThe\tAsthma\tand\tAllergy\tFoundation\tof\tAmerica\nFood\tA... | [
0.02143026702105999,
0.0017667458159849048,
0.07164046913385391,
-0.026741333305835724,
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0.05880282446742058,
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0.10805901139974594,
0.13698089122772217,
-0.1026921197772026,
0.023979632183909416,
-0.018356... |
Food\tAllergy\tResearch\tEducation\nInternational\tNetwork\tfor\tDiet\tand\tNutrition\tin\tAllergy\nReferences\nAlhmoud\tT,\tHanson\tJA,\tParasher\tG.\t\nEosinophilic\tgastroenteritis:\tan\tunderdiagnosed\tcondition\n\tDig\nDis\tSci\n\t2016;61:\t2585-2592.\nAli\tA,\tWeiss\tTR,\tMcKee\tD.\tet\tal.\t\nEfficacy\tof\tindiv... | [
0.02358621545135975,
0.006958954036235809,
0.05860079452395439,
0.005569234490394592,
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0.06730081886053085,
0.033372994512319565,
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0.0851840004324913,
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0.0360078327357769,
0.0210403... |
Efficacy\tof\tindividualized\tdiets\tin\tpatients\twith\tirritable\tbowel\nsyndrome:\ta\trandomized\tcontrolled\ttrial\n\tBMJ\tOpen\tGastroenterol\t2017;4:\te000164.\nAmerican\tLatex\tAllergy\tAssociation:\t\nWhat\tis\ta\tlatex\tallergy?\n\tAvailable\tat:\nhttps://www.allergyhome.org/\n.\nAppel\tMY,\tNachshon\tL,\tEliz... | [
0.05041719973087311,
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0.022892490029335022,
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0.0016014993889257312,
0.05999678373336792,
0.17942936718463898,
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-0.0030115293338894844,
0.05083825811743736,
0.05859104171395302,
0.04611377790570259,
0.0891... |
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