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An enzyme s ability to change conformations in response to substrate binding is fundamentally important to efficient catalysis . For example, a number of enzymes (to name a few, adenylate kinase,(1) the pbcv-1 mrna capping enzyme,(2) and dna ligase(3)) have large accessory domains, which are covalently linked via short... |
Retinochoroiditis is a common intraocular manifestation of ocular toxoplasmosis.1 in the last decade, several manifestations of ocular toxoplasmosis have been reported,15 including optic neuropathy and retinal vascular occlusion . Wong et al reported a rare case of optic disc swelling and hemispherical retinal vein occ... |
The 2013 youth risk behavior survey found that 34.9% of high school students had used alcohol and 23% used marijuana in the 30 days prior to the survey; among the 73.9% of high school students who had dated in the 12 months prior to the survey, 10.3% experienced prior - year physical dating violence and 10.4% experienc... |
The kdoqi recommended order of preference for placement of fistulae in patients with chronic kidney disease should be a forearm (radiocephalic) primary fistula, an elbow (brachiocephalic) primary fistula, a transposed brachial - basilic vein fistula, followed by arteriovenous graft (avg) of synthetic or biological mate... |
Recent experimental progress has made it possible to study light - matter interactions in the regime of strong and ultrastrong light - matter coupling . Experiments from exciton - polariton condensates, near - field spectroscopy, plasmon - mediated single - molecule strong coupling, superconducting qubit circuits, quan... |
Lipocalins family encompasses more than twenty different proteins . Theses mall, soluble protein shave different sequences with only 20% similarity to each other . However, all of them composed of 8 antiparallel beta - barrels . Lipophilic substances such as free fatty acids, retinoids, arachidonic acid and steroids pa... |
In 1992, the us centers for disease control (cdc) revised its definition of wound infection, creating the definition surgical site infection (ssi) to prevent confusion between the infection of a surgical incision and the infection of a traumatic wound . Surgical wound infection is a serious hazard to patients, with inc... |
Some papers report acute dysautonomia involving the parasympathetic and sympathetic system, like a paraneoplastic syndrome, in hodgkin lymphoma and others describe improvements after the treatment of the disease . Some studies suggest that such autonomic changes are related to the malignant disease, but others claim th... |
Ischemic stroke is the second leading cause of death in major industrialized countries, with a mortality rate of around 30%, and the major cause of long - lasting disabilities . Ischemic stroke results from a transient or permanent reduction in cerebral blood flow which is, in most cases, caused by the occlusion of a m... |
Coconuts (cocos nucifera linn .) Belonging to the family arecaceae are cultivated mainly in the tropical areas of high humidity, regular rainfall, and sandy soil . Countries such as india, sri lanka, indonesia, and philippines have major share in the global production of coconuts . India is the largest producer of coco... |
Polypoidal choroidal vasculopathy (pcv), which was first described by yannuzzi et al, is characterized by numerous recurrent, bilateral, asymmetric, serosanguinous detachments in the retinal pigment epithelium.1 several treatment strategies have been reported for pcv.2 among them, photodynamic therapy3 and intravitreal... |
Phenylketonuria (pku; omim 261600) is an inborn error of metabolism caused by deficiency of hepatic phenylalanine hydroxylase (pah; ec 1.14.16.1) due to autosomal recessively inherited mutations in the pah gene . Pah catalyzes the conversion of l - phenylalanine (l - phe) to l - tyrosine using molecular oxygen and the ... |
Health spending in the united states reached $425 billion in 1985, up 8.9 percent from the previous year . This growth was the slowest in two decades, but the slowdown was attributable almost entirely to lower growth of prices . Person, but rather a commitment of resources on a national level . Of the funding for healt... |
The most common surgical techniques are discectomy with or without fusing the two adjacent intervertebral bodies . Robinson and smith [3, 33, 34, 38] introduced the anterior cervical decompression technique without microscope, but with fusion by inserting a bone graft harvested from the iliac crest of the patient . Han... |
The prosthodontic rehabilitation of edentulous patients has been used over the years primarily for esthetics purposes after mandible resection . The development of osseointegrated implants allowed the production of more stable overdentures, improving retention and stability, thereby improving prosthetic rehabilitation ... |
A growing body of empirical evidence suggests that the origins of obesity and metabolic dysfunction can be traced back to the intrauterine period of life, at which time the developing fetus is acted upon by and responds to suboptimal conditions during critical periods of cellular proliferation, differentiation, and mat... |
We simulated data with alf (dalquen et al . 2012) using the same basic setup as in a previous simulation - based benchmarking study of orthology prediction (dalquen et al . 2013): we used a topology with 30 species sampled from the tree of 224 -proteobacteria as estimated by the oma project (altenhoff et al . The ances... |
Alcohol dependence causes physical and emotional problems and has a huge impact on family life, employment, violence, and crime.13 families and society are disrupted . Abuse of alcohol affects nearly every bodily system and increases the risk of certain types of cancer (ie, oral, pharyngeal, liver, and lung cancers).4,... |
According to estimates from the unaids global report 2010, at the end of the year 2009 the prevalence of hiv worldwide was around 30.8 million in adults and 2.5 million in children . Aids killed 2.1 million people in the course of that year, including 3,30,000 children, and 76% of those deaths occurred in sub - saharan... |
Helicobacter pylori (hp) is an important etiologic cause of diseases such as chronic gastritis, duodenal and gastric ulcers, atrophic gastritis, intestinal metaplasia, and gastric lymphoma (mucosa - associated lymphoid tissue, malt lymphoma type) [1, 2]. Many studies suggest a relationship between iron deficiency anemi... |
Apart from an esthetic concern, excessive gingival exposure with lip incompetence is considered an instigation factor for gingivitis in anterior maxillary region.1,2 osteotomy surgery combined with orthodontic therapy is considered the standard treatment in the management of maxillary excess . But this treatment modali... |
Proton - coupled electron transfer (pcet) reactions encompass a broad spectrum of mechanisms . For example, such reactions may be sequential or concerted, depending on the existence of a stable intermediate . If a stable intermediate is observed, then the reaction is clearly sequential, but detection of the intermediat... |
Fruits of citrus aurantifolia (christm) were collected from gardens near the shiraz city, fars province, iran in summer of 2008, and identified by a botanist at the biology department, science faculty of isfahan university, isfahan, iran . A voucher specimen (5527) the whole peal of fruits was dried at room, pulverized... |
Transcription factors (tfs) are key regulators for transcriptional expression in biological processes (1). During the past years, several databases of plant tfs and other transcription regulators have been publicly available, such as plntfdb (2), planttapdb (3), grassius (4), datfap (5), agris (6), rartf (7), legumetfd... |
As student travel to malaria - risk regions increases, malaria education becomes a more pressing need because infection can rapidly lead to permanent disability or death . Many travelers have limited knowledge of malaria despite it being a leading cause of death worldwide, with 200 - 300 million infections and nearly o... |
Multiple classification schemes exist for rotator cuff tears; morphologically, the type (partial or full thickness), size (small, medium, large or massive), geometry (crescent, l - shaped, u - shaped), and level of retraction, have been used to describe various tear patterns . In addition to the morphology, rotator cuf... |
The ability to treat bacterial infection is critical to modern medicine, from abdominal surgery to transplants to cancer management . Without antibiotics, these procedures would be unthinkable owing to the infection risk . Yet this ability to beat infection has existed for only a brief fraction of human history, beginn... |
One of the key features of the adaptive immune system is the formation of immune memory upon infection . When edward jenner back in 1796 observed that milkmaids were protected against smallpox due to their exposure to the pus in the blisters from cowpox, he did not know that his discovery would lead to one of the first... |
The precise identification of some fungal species is often very difficult when using only biochemical or phenotypic methods (dooley et al ., 1994; fenn et al ., 1994 however, the advent of dna - based methods largely overcame the limitations of traditional methods and studies using molecular approaches revealed a great... |
In the past, protein crystallization was mainly used for protein structure determination . To date, about 90% of all protein structures have been determined by employing protein crystals for x - ray crystallography . On the basis of their three - dimensional (3d) structure, protein crystals are considered fragile since... |
Lercanidipine (ler), () 2-[(3,3-diphenylpropyl)methylamine]-1,1-dimethylethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5 pyridinedicarboxylic ester (figure 1), is a dihydropyridine type calcium - channel blocker known to effectively and safely reduce high levels of blood pressure, with a low adverse effect [... |
In canada, physicians are responsible for assessing medical fitness to operate a motor vehicle; however, guidelines for reporting medical fitness to local licensing authorities vary by province and territory . Nova scotia is one of three provinces where the reporting of potentially unsafe drivers is at the discretion o... |
Aneurysms of the ductus arteriosus in adults are rare findings and the true incidence is unknown . Previously, most cases were discovered at autopsy or in those undergoing cardiac surgery for another indication . Widespread use of cross - sectional imaging in the adult population has led to increased diagnosis of this ... |
Patient 1, a 36-year - old woman who worked as a technician in a clinical laboratory, was admitted to bordeaux hospital, france, on june 2, 2009 . She had a 7-day history of high fever (up to 395 c), rigors, headache, and jaundice . Hematologic tests showed decreased platelets (33,000 10 platelets / l) and increased se... |
You grew up in new york state and stayed for college, graduate school, and your postdoc . I had a pretty strong case of insecurity and the imposter syndrome until i was about 45 . I liken it to the scene in a beautiful mind, in which the economist john nash realizes that the little girl in his life is a delusion becaus... |
Limbic encephalitis (le) is an uncommon neurological disorder characterized by a subacute and progressive altered consciousness, memory disturbance, and recurrent seizures . Antibodies including anti - hu, anti - yo, anti - cv2/crmp5, anti - ri, anti - ma2, and anti - amphiphysin are associated with paraneoplastic le .... |
Our work is supported by the state committee for scientific research, grant numbers 6 p04a 025 - 18 and 6 p04a 016 20 . The continuous line is the dna strand replicated as the leading strand; the dashed line is the dna strand replicated as the lagging strand; ori, the origin of replication; ter, the terminus of replica... |
It is well known that serum calcium (ca) level is regulated within a narrow range by actions of two calcium - regulating hormones, parathyroid hormone (pth) and 1,25-dihydroxyvitamin d [1,25(oh)2d]. In contrast, while derangements in serum phosphate level result in rickets / osteomalacia or ectopic calcification, the r... |
Tumor - to - tumor metastasis, although uncommon, is not as rare as once thought . Since berent's first documentation of a case in 1902, over 150 cases the most commonly reported recipient tumor is a renal cell carcinoma and there are several theories to support this phenomenon . Pulmonary carcinoma is noted to be the ... |
A large number of patients with depression have incorrect and negative views not only toward antidepressants but depression itself.16 the most common misperception among these patients is that depression is caused only by nonbiological or environmental factors, such as stress or family problems.79 patients also believe... |
Field - cultivated ginseng roots were collected 20 different plots growing ginsengs from 1 to 5 year - old plants in geumsan - gun, korea (n 3603'~05', e 12732'~33'), with 4 replicate plots for each age . A root sample was used for each plot in this study, making a total of 20 samples . To examine amf colonization rate... |
Since its inception in 1999, the stanford microarray database [, (1)] has grown in its size and scope . It has become a research tool for a large scientific community that is no longer restricted to stanford researchers and smd now supports the research of over 1200 active users in close to 300 laboratories around the ... |
Sarcopenia, defined as an age - related loss of muscle mass and low muscle function, may be the most prominent component of frailty, disability, and morbidity in older people.1,2 although this relatively new geriatric syndrome3 represents a challenging burden for health care systems not only, but particularly, in devel... |
Feline leukaemia virus (felv) is a gammaretrovirus, first described in 1964 at the university of glasgow . Since the 1980s, significant decreases have been observed in countries with testing and vaccination programmes, while prevalence remains high in some regions . In europe, a belgian study in 2002 calculated a preva... |
Extrinsic factors, such as genetics, race, and age, [13] or intrinsic factors, such as trauma, intraocular surgery, ultraviolet radiation, and infection [46] are responsible for maintaining the structural and functional integrity of the corneal endothelium . Clinical observations indicate that an endothelial cell densi... |
On august 19, 2013, two persons from sancaktepe village, turkey, sought care for influenza - like symptoms, tonsillitis, and swollen neck lymph nodes . Clinicians treating the patients did not perform lymph node biopsies or conduct pcr testing of blood specimens to identify f. tularensis . Over the following weeks, we ... |
A self - expandable metal stent (sems) is an efficient and established tool for solution of biliary obstruction due to both benign and malignant diseases . Meanwhile, there have been some reports regarding adverse events by a sems: migration, dislocation, ulceration, perforation of the bowel and so on.1 we sometimes en... |
Immunoglobulin g4-related disease (igg4-rd) is a very recently defined emerging entity characterized by a diffuse or mass forming inflammatory reaction rich in igg4-positive plasma cells associated with fibrosclerosis and obliterative phlebitis, and it is found to affect an increasing number of organs or systems (1, 2)... |
Pulmonary artery (pa) dilatation associated with severe pulmonary hypertension is a rare condition . Despite its rarity however, unexpected deaths may result more frequently than commonly believed.1)2) possible mechanisms of sudden death include left main coronary artery (lmca) compression by a markedly dilated pa and ... |
Primary anterior teeth are the most commonly affected teeth due to early childhood caries and trauma . According to huber et al ., they are called the social six as they are the most prominent teeth in a smile . Loss of primary anterior teeth leads to mastication problems, speech disorders such as difficulty in pronunc... |
Randomized controlled trials (rcts) provide the best evidence to support the efficacy and safety of therapies and form the basis for regulatory approval of treatment for all diseases, including chronic obstructive pulmonary disease (copd). A well - designed rct has a high degree of internal validity and allows for data... |
Treatments for intratumoral hemorrhage in renal angiomyolipoma (aml) include nephron - sparing surgery, radical nephrectomy, and transcatheter arterial embolization . Superselective coil embolization is an effective, minimally invasive procedure for the treatment of intratumoral hemorrhage in aml from the perspectives ... |
In the previous issue of critical care, lorente and coworkers reported the results of a prospective cohort study evaluating matrix metalloproteinases (mmps) and tissue inhibitors of metalloproteinases (timps) as potential biomarkers for the determination of sepsis severity and for the prediction of mortality in septic ... |
The genetic events and their relationship to the complex interaction with the microenvironment transforming normal melanocytes into melanoma are under intensive investigation . In the last decade melanoma was dissected into several molecular subgroups on the basis of genomic alterations, including mutations, deletions ... |
Although in the adult central nervous system (cns) some potential for neurogenesis (in the gray matter) and axonal regrowth (in the white matter) exists, the response to stimulation (neuroplasticity) and injury (neuroregeneration) in the cns is mainly based on a synaptic reorganization of the existing / surviving neuro... |
Pneumocystis jirovecii pneumonia (pjp) is one of the most life - threatening infections in immunocompromised patients . Typical computed tomography (ct) findings of pjp include diffuse ground glass opacity in both lungs, but cystic formation or pneumothorax can also be seen, and nodules are found on rare occasion (1, 2... |
Ectopic thyroid may occur in four general locations based on the natural descent of the thyroid tissue from its embryologic starting point at the base of the tongue to its final resting position anterior to the trachea: lingual, sublingual, pre - laryngeal, and substernal (in the mediastinum) (1). The base of the tongu... |
When the vaginal bleeding is cyclic and lasts for two to five days, isolated menses should be considered . The first menstruation normally appears approximately two and a half years after the onset of breast development . The occurrence of a menstrual - like bleeding before telarche is very rare and has also been defin... |
Carbon quantum dots or carbon dots (c - dots) have become a colossal designation in the field of material science, since its serendipitous inception in 2004 during separation of multiwalled carbon nanotubes under electrical influence . In medicine and theranostics, c - dots have emerged as new advancement owing to thei... |
Traditional medicines derived from botanical products have been used in regions such as africa, asia, and india for many years . The use of herbal materials in medicines, food supplements, and teas has increased substantially in western countries in recent years, leading to concerns about safety assessment of these pro... |
Emergency medicine is the specialty that cares for the care seeker, at the most vulnerable moments of their life . It faces the challenge of evaluating the early phases of the biological behavior in diseases . Urgency, unpredictability and the need to acquire skills of the entire spectrum of age, gender and the patholo... |
Rag2c mice were backcrossed onto the balb / c background and balb / c rag2c mice on a nude background were bred and maintained in isolators with autoclaved food and water under a protocol approved by the amc - uva . Mice with a his were generated as previously described (15, 16). In brief, newborn (35-d - old) rag2c mi... |
Insulin resistance is a disorder characterized by the improper utilization of glucose by the cells . This is because of an existing and/or acquired impairment of the cell's ability to respond to exogenous or endogenous insulin . This, in turn, results in -cell compensation failure and excessive blood glucose levels in ... |
Papillary carcinoma is the most common type of thyroidal malignancy (1). Within variable morphologic variants of papillary thyroid carcinoma (ptc), follicular variant of ptc comprises 15%-20% of ptc, which is the second most common variant following the conventional ptc (2). Among the various subtypes of follicular var... |
Breast surgeries are commonly performed under general anaesthesia . Concomitant use of interpleural block can help to minimize pain and narcotic requirement during the perioperative period. [13] interpleural block is the technique of injecting a local anaesthetic into the space between the parietal and the visceral ple... |
Primitive neuroectodermal tumor (pnet)/ewing s sarcoma (ews) belongs to a family of neoplasms that are presumed to originate from the neuroectodermal crest . Pnet / ewss are highly aggressive malignancies that usually present in the form of bone or soft tissue masses and usually affect adolescents and young adults . We... |
Prone positioning is widely used to improve oxygenation of patients with acute respiratory distress syndrome (ards). In the previous issue, robak and colleagues report the short - term impact of combining two positioning strategies, prone and upright positioning . Although randomized controlled trials failed to demonst... |
Clinical investigations comprised detailed neurologic examination, mri at 1.5 t, 3 t, and 7 t, magnetic resonance (mr) spectroscopy at 3 t, and longitudinal csf analysis . Written informed consent was obtained from the patient for all procedures . Clinical routine mri at 1.5 t and 3 t included t1-weighted (t1w), t2-wei... |
Nitric oxide (no) is a diatomic free radical synthesized from the conversion of l - arginine to l - citrulline by nitric oxide synthase (nos). No is relatively unstable in the presence of oxygen and quickly auto - oxidized to produce nitrogen oxides . Because of no s reactivity and short - life, direct measurements of ... |
Endodontic infections present a polymicrobial nature, which include the presence of fungal species . Enterococcus faecalis has been frequently isolated among the microorganisms of endodontic infections, even in persistent infections after root canal treatment . The predominance of anaerobic bacteria within this microbi... |
The liver plays an important role in human metabolism and detoxification of endogenous and exogenous chemicals . Especially acute and chronic liver injuries resulted from the exposure to toxic chemicals, drugs, and virus infiltration from ingestion or infection, have gained more attention in recent years.2, 3, 4 cortic... |
Intravenous recombinant tissue plasminogen activator (rtpa) infusion was the first approved treatment for acute ischemic stroke . However, this treatment has limited efficacy in patients with intracranial large artery occlusion, and only a subset of patients experience recanalization . In patients with underlying intra... |
Asian faces tend to scar badly after burn injury and despite the best of efforts, results are not satisfactory . Compared with caucasian patients, asian burn wounds tend to scar much worse because of increased skin thickness and sebaceous gland activity . Chemical burns to the head and neck are recognised to be a parti... |
The revival of off - pump cardiac surgery and the exploration of less invasive techniques for coronary artery bypass grafting, have lead to an increasing technical difficulty, as compared to conventional surgery using cardiopulmonary bypass . The moving target vessel in off - pump coronary artery bypass surgery, as wel... |
Cyclosporin a (csa) is one of the basic immunosuppressive drugs widely used to prevent organ transplant rejection and for the treatment of other immune diseases, such as behet's disease, rheumatoid arthritis, systemic lupus erythematosus, crohn's disease, ulcerative colitis and insulin dependent diabetes mellitus . The... |
Multiple myeloma (mm) is a human b - cell neoplasm characterized by the clonal expansion of malignant plasma cells in the bone marrow . The cause of this disease is only partially understood, but the production of soluble factors by the myeloma cells is likely to be involved . The most important complications are hyper... |
They occur following motor vehicular accidents, falls, and stabs or after laparoscopic upper abdominal surgeries . Though penetrating chest and abdominal injuries have higher chances of causing diaphragmatic hernias, it is well known that blunt trauma is associated with the condition . The diagnosis of a diaphragmatic ... |
The university of pittsburgh medical center (upmc) operates 20 hospitals throughout western pennsylvania . When a patient passes away, the decedent requires extensive paperwork, transportation, and, occasionally, an autopsy . The pathology department is often involved in managing these cases, including performing all m... |
Inappropriate use of acute headache medications by patients with frequent migraine or tension - type headache may contribute to the development of a chronic, daily (or almost daily) headache that is induced and maintained by the use of the painkilling drugs . This very aggressive and disabling type of headache, now lab... |
Piroxicam (pir) (4-hydroxy-2-methyl - n-(pyridine-2-yl)-2h-1,2-benzothiazine-3-carboxamide-1,2-dioxide) is a well - known nonsteroidal anti - inflammatory and analgesic drug, indicated for acute or long - term treatment of inflammation associated with musculoskeletal and joint disorders, such as osteoarthritis, rheumat... |
This was surprising because he had had no interest in such materials up to that point in his life . He also found himself attracted to his 12-year - old stepdaughter, with whom he and his wife lived . The judge gave michael the option of avoiding jail time should he pass successfully through a treatment program . Micha... |
Muscle atrophy is characterized by a reduction in muscle protein synthesis or an increase in protein degradation [14] that results in decreased fiber diameter, force production, and fatigue resistance . Muscle atrophy is often caused by injury, fasting [711], disease [1221], or immobilization [1, 8, 10, 11, 2227]. In a... |
Embryos derived from parthenogenetic activation of in vitro matured porcine oocytes were produced, transferred into recipient females, and harvested on day 14 of gestation as described elsewhere . The ivv embryos were produced by artificial insemination according to standard industry practices, and were harvested by ut... |
Solute carrier (slc) transporters are increasingly recognized as essential for ion, molecule, and other solute transport to support lysosomal function . To date, more than 30 lysosomal slc transporters have been genetically identified, molecularly characterized, and investigated for a role in health and disease . Despi... |
Micrornas (mirnas) play a key role in the posttranscriptional regulation of gene expression by guiding the association between the rna - induced silencing complex (risc) and target rnas (reviewed in fabian et al ., 2010). Human cells express more than 1,000 mirnas, each potentially binding to hundreds of messenger rnas... |
Cisplatin - based combination chemotherapy protocols such as methotrexate, vinblastine, doxorubicin and cisplatin, or gemcitabine and cisplatin have been a mainstay for advanced (or metastatic) bladder cancer (bc) treatment for a number of years and have prolonged the survival of these patients by up to 19 months . How... |
Recent experimental and in silico studies have resulted in a much better understanding of the principles and mechanisms of prokaryotic signal transduction (16). The list of recognized environmental sensors has been dramatically expanded and now includes, in addition to two - component histidine kinases and methyl - acc... |
Lauralyn mcintyre and colleagues have neatly used a septic shock scenario - based survey to highlight considerable variations within canadian critical care practice . They acknowledge the potential pitfalls of translating survey results into' real life'; however, my own experience of the diversities within uk practice ... |
Sequencing the mrna in a cell has been used as a high - throughput method for finding genes since the early days of the human genome project . Beginning in the early 1990s, the expressed sequence tag (est) method was used to capture fragments of thousands of human genes prior to the sequencing of the genome . Est seque... |
Over time, the goal of aging in place has become a focal concept by policy makers as well as researchers in their collective efforts to create communities that facilitate the widely recognized preference by a majority of older adults to remain in their homes and communities as long as possible [14]. Efforts to reform h... |
Patients with c1 nerve root schwannomas usually present with signs relating to nerve root compression . However, asymptomatic presentations have never been reported . A healthy, 37-year - old female was referred in view of a slow - growing lump in the left posterosuperior aspect of the neck . Magnetic resonance imaging... |
Clinical clues apparent on examination can expand or narrow the differential diagnosis substantially, even when the patient is seen first for management of a life - threatening condition in the intensive care unit (icu). We present a female patient with presumed chronic inflammatory demyelinating polyneuropathy (cidp) ... |
The size of the hiv - infected population and the longevity of hiv - affected patients is increasing due to the highly active anti - retroviral therapy (haart). As a result a lot of diseases affecting various organ systems in the normal population are becoming manifest in these hiv patients . Previously, only few disea... |
A national cohort of veterans with type 2 diabetes was created by linking patient and administrative files from the veterans health administration (vha) national patient care and pharmacy benefits management databases . Veterans were included in the cohort if they had 1) type 2 diabetes defined by two or more icd-9 cod... |
Chronic pelvic pain (cpp) is defined as non - menstrual or non - cyclic pelvic pain lasting for at least 6 months that interferes with normal activities and requires medical or surgical treatment . According to gelbaya and el - halwagy, cpp is considered a major health problem for women . In the u.s.a ., cpp is respons... |
Prostate cancer is a major health problem in the male population both in poland and europe . In 2012, with the number of new cases in europe up to 416,730 (representing 22.8% of all cancer cases in male population), pca placed first in terms of highest incidence of malignancy in men . The awareness of suffering from pr... |
Glaucoma with both its entities, open angle glaucoma (oag) and angle closure glaucoma (acg), affected about 60.5 million people worldwide back in 2010 . There are many topical antiglaucoma medications, and most of them work through lowering intraocular pressure, the only treatable risk factor of glaucoma . Poor complia... |
Chordoma is a low - grade malignant tumor that arises from the remnants of notochord . They account for 1 - 4% of malignant bone tumors and most commonly present after the age of 30 years . Majority occur in sacrum or in the clivus (a bony surface in the posterior cranial fossa sloping upward from foramen magnum to dor... |
Aav2/8 was produced by transient transfection and purification from culture supernatant by peg precipitation and cesium chloride ultracentrifugation . Virus was quantified by qpcr against cmv sequences and functionally validated in vitro to confirm gene expression prior to use in vivo . Antibody concentration in the se... |
In general, there are two categories of geometric quantities and their corresponding two kinds of flows: intrinsic quantities, such as the metric of a manifold, and the extrinsic quantities such as the embedding of a manifold in some ambient space . The ricci flow, the calabi flow, and the yamabe flow belong to the fir... |
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