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Sensor - augmented pump systems provide insulin delivery and continuous glucose monitoring therapies that can improve the management of diabetes . The minimed paradigm veo and minimed 530 g systems (medtronic, northridge, ca) are capable of suspending insulin delivery in response to sensor glucose (sg) values at or bel...
Several groups in canada and the us have recently pondered disastrous scenarios where demand for hospital admission and critical care resources would vastly outstrip supply in an influenza pandemic or other health emergency . Rather than leave wrenching prioritization decisions to exhausted, frontline health profession...
Experimental evidence indicates a critical role of cyclic guanosine monophosphate (cgmp) in antinociception . This evidence is in line with the observation that local administration of l - arginine produces antinociception in rats with carrageenin - induced hyperalgesia, the effect being blocked by nitric oxide (no) in...
Nursing forms the backbone of patient care management in an intensive care setting . The overall care, including patient comfort and sedation, is provided by the nursing personnel . Because of lack of scientific sedation practices in the intensive care unit (icu), patients usually face over- or undersedation . The resu...
Central corneal thickness (cct) measurement plays a major role in diagnostic and therapeutic approaches to corneal pathology and has an important impact on intraocular pressure readings . An ideal method of corneal thickness measurement should be accurate, repeatable, reproducible, and safe, as well as easy and quick t...
Eligible schools were participants in the epipen4schools program, which provides epipen (epinephrine injection) auto - injectors (mylan specialty l.p .) And training materials to qualifying public and private kindergarten, elementary, middle, and high schools in the us . Participating schools received two epipen auto -...
Small cell carcinomas (scc) are the most frequent subtype among them and account for approximately 0.51% of all primary neoplasms of the urinary bladder . Pure scc of the bladder is known to be of high metastatic potential with lymph nodes, viscera, and vertebral bones being the most common sites of secondary deposits ...
The tropical medicine foundation of amazonas is a tertiary care center for infectious diseases in manaus (38s, 601w). In 2001 and 2002, a total of 13,056 cases of malaria were diagnosed in this institution (11,251 p. vivax), representing 65.1% of the total cases from manaus . During the same period, 358 (3.2%) a retros...
Charles darwin suffered illness for most of his adult life with many very differing symptoms . Some of these symptoms were present when he was a university student, both in edinburgh and cambridge . In edinburgh he was known to have a weak stomach and was unable to watch surgical operations; at cambridge he suffered fr...
Microvascular decompression (mvd) was introduced in the late 1960s and is a widely accepted treatment for neurovascular compression, including hemifacial spasm (hfs), trigeminal neuralgia (tn), and glossopharyngeal neuralgia . Technological advances, combined with microsurgical innovations, make this procedure effectiv...
As narms participants, 17 state and local public health laboratories representing 40% of the us population submitted every tenth non - typhi salmonella isolate, every tenth shigella isolate, and every fifth e. coli o157 isolate received in 2000 to cdc for antimicrobial susceptibility testing . The mic was determined fo...
. Characterized by a combination of hyper cellular stroma and cleft - like spaces lined by epithelium, phyllodes tumor was classically known as cystosarcoma phyllodes because of the leaf - like projections . Renamed phyllodes tumor in the early 1980s, these tumors vary greatly in size and the histological characteristi...
A notice in diabetes forecast inviting participants to evaluate bgathome.com resulted in 210 individuals completing an online screening in 10 days . Participants were the first 40 individuals who, by telephone interviews, met the following inclusion criteria: type 1 diabetes, routinely measuring blood glucose levels mo...
Clinically, the side effects of lasers on the skin include blistering, fine epidermal crusting and erosion, resulting from epidermal injury in the early stage after laser radiation . In the late stage, hyperpigmentation, hypopigmentation, scar or keloid formation this report describes peculiar clinical and histopatholo...
Benign prostatic hyperplasia (bph) is one of the most common chronic diseases in aging men . The most potent androgen in men, 5-dihydrotestosterone (dht), is widely accepted to be more essential than testosterone for prostatic epithelial cell proliferation and function . It is believed to be largely converted from test...
Pseudomonas oryzihabitans, previously known as flavimonas oryzihabitans has been placed in cdc (cdc: centers for disease control) group ve-2 . P. oryzihabitans has been recovered from various clinical samples, including wound swab, sputum, ear swab, conjunctival scrapings, urine, peritoneal fluid, and blood . We report...
With penetrating trauma reaching epidemic proportions in the caribbean, emergency room (er) thoracotomies are performed regularly . It may be life - saving by achieving four goals: (i) releasing cardiac tamponade, (ii) controlling haemorrhage, (iii) allowing access for internal cardiac massage and (iv) clamping the des...
Patients were selected by purposive sampling technique from department of psychiatry bokaro general hospital bokaro steel city, psychiatric unit and private clinics of bokaro . Only right - handed patients having basic reading and writing ability to understand the instructions given were included in the study . Patient...
Evidence suggests that the glucagon - like peptide-1 receptor (glp-1r) agonist exendin-4 (ex-4), used in the treatment of type 2 diabetes mellitus, also displays neuroprotective properties in multiple cellular and in vivo models of neurodegenerative disorders . Evidence of its potential for the treatment of these neuro...
There are various body fluids, of which saliva is the most valuable oral fluid that can aid in the diagnosis of various diseases such as hiv, hepatitis, renal disease, and detection of apoptotic cells in saliva of patients with oral carcinoma . Saliva has also become useful as a non - invasive systemic sampling measure...
Ulcerative colitis (uc) is a major type of inflammatory bowel disease characterized by chronic, relapsing intestinal inflammation with extensive damage of colonic mucosa . It is presented by a variety of clinical manifestations, including attacks of abdominal cramps, pain, bloody diarrhea, bleed per rectum, weight loss...
Metastases of breast carcinoma are commonly found in the bone, liver, lungs and the brain . Gastrointestinal (gi) involvement is rare, with only few cases of such metastases reported in the literature . Invasive lobular carcinoma (ilc) accounts for 510% of invasive breast carcinomas . Of the various histological subtyp...
In addressing issues for translational medicine, we categorize the hurdles faced by our colleagues as follows: therefore, it may behoove us to establish a common understanding of the definition of " translational medicine " to frame our expectations or frustrations . For most, " translational medicine " (or " translati...
Atrial fibrillation (af) is the most common cardiac arrhythmia, affecting 1% of the general population and with its prevalence increasing with age . Most important, af has well - documented consequences as disabling symptoms, elevated stroke risk and major risk of congestive cardiac failure, being an independent predic...
Staphylococcus aureus could be considered a major cause of human diseases, particularly in the hospital setting . It is one of the most feared pathogens because of its ability to cause overwhelming sepsis and death (1). Methicillin - resistant staphylococcus aureus (mrsa) is a bacterial pathogen frequently isolated and...
As of january 2011, peruvian migrants represent the largest latin american community in italy with 101,711 documented residents accounting for 2.9% of migrant population, corresponding to about 30% of latin americans in italy . The number of peruvian citizens in italy has increased 30 folds since the early nineties . T...
Erdheim - chester disease (ecd) is a rare non - langerhans cell histiocytosis that affects multiple organ and systems . Since the first description by chester in 1930, the disease is characterized by xanthogranulomatous infiltrates of foamy cd68/cd1a histiocytes usually surrounded by fibrosis . The etiology and pathoge...
Proteus syndrome is a hamartomatous disorder consisting of disproportionate, asymmetric overgrowth of body parts, malformations of the capillary, venous and lymphatic types, and dysregulated adipose tissue . Disproportionate overgrowth and giant hemangiomas have also been reported to involve the viscera such as spleen ...
The pathogenesis of iga nephropathy (igan) involves multiple hits [1, 2]. It is thought that increased levels of circulating galactose - deficient iga1 in association with the production of unique anti - glycan antibodies leads to the formation of pathogenic iga1 containing circulating immune complexes that are deposit...
On a glass slide, freshly cut surface of the specimen is gently pressed, misrepresentation of the cell's shape can be prevented by restricting a gliding movement . Then the slide is stained with hematoxylin and eosin stain before that it is fixed with 95% of ethyl alcohol for 56 s. however, it is extensively used in th...
The clinical protocol was approved by the human research committees at massachusetts general hospital (mgh) and boston university ., subjects were required to be aged 18 years, to have had type 1 diabetes for at least 1 year, and to have a stimulated c - peptide level in response to a mixed - meal tolerance test 0.1 nm...
In our daily lives we are surrounded by animals and plants that belong to distinct and quite clearly demarcated species . Even little children know that dogs and cats, or apples and pears, are different, and so we come to expect that different species should look different . Yet there is no biological imperative dictat...
Epidermoid and dermoid cysts are benign lesions encountered throughout the body that are derived from abnormally situated ectodermal tissue . Histologically, epidermoid cyst is a cyst lined by stratified squamous epithelium and lumen is filled with lamellated keratin while dermoid cyst contains skin adnexal structures ...
Taking drug is one of the rings of the treatment chain, while self - medication is one of the problems in treatment cycle . Self - medication without prescription is the main problem of the drug culture that, in addition, to disturb the treatment process and incidence of side effects; it imposes huge costs of the drugs...
Praxis is ability to formulate skilled movements in a nonparetic limb by planning a schema based on stored complex representations and previously learned movements and apraxia is inability to carry out a learned motor act in the absence of motor, sensory or cerebellar deficit on command . According to geshwind, apraxia...
Injection drug is one of the main modes of hiv transmission in many parts of the world, particularly in industrialized and middle - income countries, including many countries in asia (1, 2). The recent global estimation in 2014 indicates that there are 12.7 million injecting drug users (idus), and 13.1% of them are liv...
Bilateral cystic adrenal neuroblastoma with cystic liver and lymph nodal metastases and generalized intratumoral hemorrhage is extremely rare . A 6-month - old boy presented with abdominal discomfort of 15 days duration and a mass noticed for the past 2 days . He was born at term by caesarean section for fetal bradycar...
Spatial navigation is the ability to determine and maintain a route from one place to another (gallistel, 1990). It consists of phylogenetically old cognitive functions allowing animals and humans to remember important locations and their mutual relations as well as their relation to the organism itself . Spatial navig...
It is often referred to as a group of diseases because of the varied spectrum of clinical manifestations, which range from small cutaneous nodules to gross mucosal tissue destruction . Cutaneous leishmaniasis can be caused by several leishmania spp and is transmitted to humans and animals by sandflies . Zoonotic cutane...
Ribosomes catalyze protein synthesis but have only a few characterized roles in regulating it (mauro and edelman, 2002, xue and barna, 2012). Rather, the most - studied molecular regulatory mechanisms of translation are mediated by eukaryotic initiation factors, rna binding proteins, and micrornas (hendrickson et al .,...
Breast cancer evolves from normal epithelium of the terminal duct or lobular unit through a series of increasingly abnormal proliferative lesions beginning with atypical hyperplasia, to premalignant in situ disease, to malignant and increasingly invasive neoplasia [13]. In situ carcinoma is characteristically contained...
Between 25% and 40% of childhood epilepsies are caused by malformations of cortical development (mcds).1 mcds result from abnormal neuronal and glial proliferation or differentiation (tuberous sclerosis, focal cortical dysplasia [fcd], hemimegalencephaly), anomalous neuronal migration (subcortical band heterotopia, per...
Microarray expression analysis has become one of the most widely used techniques for the assessment of gene expression on a genomic scale, allowing tens of thousands of genes to be assayed in a single experiment . Although the results that have emerged from microarray profiling have been impressive, as the technique ha...
When managing chronic diseases, understanding the patients perspective in terms of expectations, concerns, and beliefs about their disease could result in better patient physician communications and consequently improve management of the disease.1 personality traits and health care beliefs are likely to affect patient ...
Although the prevalence of tobacco use is decreasing, one of five adults in the u.s . Still smokes, and cigarette smoking continues to be the leading cause of preventable illness and death . The highest rates of tobacco use occur among people with the lowest levels of income and education . Low socioeconomic status (se...
Tumors on the surface of the skin are generally visible and considered to be easily recognizable both for health - care professionals and for the patients themselves . However, people with neglected advanced skin neoplasms are still encountered in dermatological practice in the 21st century . There can be numerous caus...
Cell contacts with the extracellular matrix (ecm) provide both cohesive and functional properties in a variety of tissues, such as epithelia, nerves, muscle, and stroma, through specific interactions with cell membrane receptors [1, 2]. All ecms are made up of collagen fibrils and/or networks, proteoglycans as well as ...
A first depressive episode at older age is defined as late onset depressive symptoms (lodss). Lodss are usually defined by their occurrence after the age of 60 years, while early onset depressive symptoms (eodss) appear before . The prevalence of lods and eods ranges from 10% to 32% [14] in the elderly population . Pat...
As bariatric surgery becomes one of the most common general surgical procedures, a concomitant increase in revisional bariatric surgery is also being seen . Patients who have had a vertical banded gastroplasty (vbg), non - adjustable gastric banding (sometimes known as the molina band), and laparoscopic adjustable band...
This antigen belongs to the cancer - testis antigens, all of which are absent in normal tissues, but are detected in cancers, including melanoma, breast cancer, lung carcinoma, renal cell carcinoma, and leukemia . Unlike other cancer - testis antigens, prame shows some expression in normal tissues, such as testis, ovar...
A 70-year - old male was admitted to our hospital primarily due to pain and swelling of the left knee that had been present for more than 1 month . He had no specific diseases except for diabetes and was transferred to our institution due to signs of inflammation observed in a fine needle aspiration biopsy performed at...
Pancreatic oxidative stress occurs during an early stage of pancreatitis.1 - 3 scavenger therapy for reactive oxygen species (ros) showed some success in experimental pancreatitis models, including cerulein pancreatitis.4,5 in human acute pancreatitis, the increased levels of lipid peroxide in the bile or pancreatic ti...
Baboon syndrome or symmetrical drug .- related intertriginous and flexural exanthema . May be induced by systemic administration of substances including contact allergens such as mercury and nickel, and multiple drugs . Baboon syndrome (or systemically induced allergic contact dermatitis) is characterized by the occurr...
The association between ebv and human malignancies, including endemic burkitt s lymphoma, hodgkin lymphoma and non - hodgkin s lymphoma (nhl) of either b- or t - immunophenotypes, has been reported . Subsequent study revealed the constant association of nktcl with ebv in the world (fig . Sino - nasal lymphomas are immu...
Melioidosis is a disease caused by the pathogen burkholderia pseudomallei and the classical endemic regions are southeast asia and territory of northern australia . Outside these regions the disease is uncommon, but b. pseudomallei is a facultative gram - negative bacillus found in soil and surface water in the endemic...
Ischemic preconditioning (ipc) is a phenomenon during which transient sub lethal episodes of ischemia before a prolonged ischemia / reperfusion injury provide cardioprotection for subsequent longer duration ischemic events.1 hearts exposed to ipc have a better metabolic and ionic status during prolonged ischemia compar...
Medical treatment is the main strategy to control secondary hyperparathyroidism in patients with end - stage renal disease (esrd). For this reason, invasive procedures such as intranodular ethanol injection (percutaneous ethanol injection therapy, peit) or parathyroidectomy have been proposed [2, 3]. The type of proced...
Sickle cell anemia inherits as an autosomal recessive disorder that was first described by herrick in 1910 and its alleles are frequent in regions where malaria is endemic . A homozygote a to t transversion results in the substitution of glutamic acid by valine in the sixth amino acid of the human -globin chain . Inher...
First described by hungarian dermatologist kaposi in 1872, kaposi's sarcoma (ks) is a rare low - grade, vascular tumor associated with the human herpes virus 8 (hhv-8). Ks is divided into four epidemiological subtypes: (a) classic (indolent cutaneous proliferative disease affecting older men of mediterranean and jewish...
Ever since the first human cardiac transplant was performed in1967 by christian bernard, now, the average frequency of this procedure is approximately 1% of the population with heart failure . With improved graft function and survival, these patients are now presenting to hospitals for various non - cardiac procedures ...
A 28-year - old female patient presented to the department of oral medicine and radiology of the institute for technology and sciences dental college, muradnagar, ghaziabad, india with a chief complaint of inability to open her mouth for 23 years . The patient's history revealed that ulceration on the tongue occurred w...
The surface cap - sular polysaccharide of s. pneumoniae initiates a type - specific protective immune response and provides the basis for serotyping of this organism . Currently, more than 90 different pneumococcal serotypes have been identified . Among the various serotypes and according to 60 - 80 percent of the worl...
Graves disease is a prevalent autoimmune disease that affects approximately 0.5% of the population and is the most common cause (50% to 80%) of hyperthyroidism . Antithyroid drugs have been used as standard therapy for graves disease and interfere with thyroid hormone synthesis . These drugs, however, have various side...
Asthma, a chronic inflammatory respiratory disease, is highly prevalent in the us and associated with major health burden worldwide . The goal of therapy is to achieve long - term control of asthma symptoms while minimizing treatment side effects . Current guidelines recommend a stepwise approach to pharmacologic thera...
For many patients, chronic kidney disease (ckd) is a progressive condition marked by deteriorating renal function ultimately leading to end - stage renal disease (esrd). Ckd is reported to affect 15.1% of the population and is associated with a substantial disease burden as evidenced by increased morbidity and mortalit...
Prostacyclin synthase (pgis) is an atypical cytochrome p450 enzyme, which generates prostacyclin (pgi2) from prostaglandin h2 (pgh2), provided by cyclooxygenase-1 (cox1) or cox2 . Prostaglandin - i synthase is expressed constitutively, consistent with its tata - less and gc - rich promoter . However, in vitro studies h...
All three cases were transferred to our hospital after elective spine surgery under general anesthesia in a local hospital . After induction of anesthesia with propofol and vecuronium, orotracheal intubation was performed without any difficulty (cormack 1, 1st attempt) using a single lumen internal diameter (i d) 7.0 m...
Over the past several decades, research on health literacy has become increasingly relevant to gerontologists, as studies have shown that older adults' health literacy is an important factor in their health status and service utilization [14]. Health literacy has been defined as the degree to which individuals have the...
Dentures as an indwelling medical device in an individual s mouth, prepare an optimal environment for adhesion and colonization of both pathogenic and non - pathogenic organisms, and can cause inflammatory lesion of the oral mucosa (1). Denture stomatitis known as a chronic inflammatory condition of the palatal and alv...
The importance of the morphological properties of materials can be evidenced by the large number of publications on their synthesis . The development of new synthesis methods may lead to materials, such as catalysts, with superior performance . It is interesting to produce materials with nanometric - scale structures t...
The phosphorylation of specific protein residues is a crucial event in the regulation of several cellular processes, operating on activation, deactivation or recognition of the target protein . A great deal of eukaryotic proteins (30% in the human genome) undergo this reversible post - translational modification (1). P...
The first four knees in three patients received a press fit condylar ps implant (depuy inc ., warsaw, in, usa); the remainder of the cohort was implanted with a nexgen legacy ps prosthesis (zimmer inc ., knee rom data included passive flexion contracture, further flexion, and total knee arc rom (knee flexion minus flex...
Salinity continues to be a major factor in reduced crop productivity and profit in many arid and semi - arid regions, despite the advanced management techniques developed in recent decades . For example, yeo (1999) estimates that> 20% of the irrigated land worldwide has been seriously affected by salinity . Attempts to...
Cosmetics refer to all of the products used to care for and clean the human skin and make it more beautiful . The intentions of using cosmetic products is to maintain the body in a good condition, protect it from the effects of the environment and aging processes, change the appearance, and make the body smell nicer . ...
In malaysia, up to 60% of schooling adolescents suffer from different degrees of anemia based on hemoglobin concentration (1). In respect to the escalating trend of anemia among adolescents in this country, and scanty data on this nutritional problem among this age group, thus, this interventional study was carried out...
Posttranslational modification of proteins by phosphorylation plays a complex and critical role in the regulation of numerous biological processes . In recent years, large efforts have been devoted to global - scale analysis of protein phosphorylation sites using various phosphoproteomics methodologies [1, 2]. These ph...
Knee oa is one of the most common joint disorders and causes considerable pain and immobility . The initial treatment is nonoperative and consists of patient education, weight reduction, physical therapy, and, if needed, medication . Drugs rarely relieve the symptoms entirely and mainly act as a palliative agent . Othe...
Adverse events (aes) caused by medication errors (mes) continue to be one of the great challenges in acute care settings . Recent data suggest that each year more than 1.5 million patients are harmed by me in the united states . According to the report preventing medication errors, me affect approximately 5% to 10% of ...
Vitamin d is important for human health, and lower serum 25-hydroxyvitamin d [25(oh)d] has been associated with increased mortality . Moreover, a high prevalence of vitamin d deficiency has been identified worldwide in recent years . . As vitamin d is liposoluble, its oral absorption could increase if ingested with a f...
Post - activation potentiation (pap) is a neuromuscular phenomenon in which the force and power output of a muscle is immediately enhanced after heavy resistance exercise (9). The underlying principle of the ability of pap to increase force and power output of muscle is theorized to be a result of phosphorylation of my...
5-amp - activated protein kinase (ampk), a key regulator of cellular energy homeostasis, is activated in response to various metabolic stresses including starvation, hypoxia, and ischemia . Ampk is a heterotrimeric enzyme, which is activated by phosphorylation of thr172 on its subunit . Several upstream kinases can mod...
Hiv / aids has been recognized as one of the most important public health problems in the recent past, especially in asian countries such as malaysia, china, thailand, and iran . According to the world health organization's (who's) report of hiv, iran is categorized as one among the countries with gradually accumulatin...
Diabetes is a major cause of health concern in the world and is growing in epidemic proportions . It is assumed that in the next ten years it will become number one disease of the world1 . Type-1 diabetes mellitus (t1 dm) is an autoimmune disease while type 2 is mostly a lifestyle disease . Majority of people suffer ma...
Tremor is the most common movement disorder which is defined as a compulsively, rhythmic, shaking movement of a body part . One of the most general reasons for tremor is idiopathic parkinson's disease (pd), a progressive neurodegenerative disease . The core clinical features of idiopathic pd include bradykinesia, follo...
In 2002, the national institute for health and clinical excellence (nice) recommended that provided choice was offered to all those clinically suitable, up to 15% of dialysis patients might choose to undertake hhd . This seemed an attractive option, offering the potential to supplement a declining uk peritoneal dialysi...
Eukaryotic cell membranes are rich in cholesterol . Because this sterol is thought to play a major role in determining the structure and function of these life - sustaining enclosures, it has been the subject of numerous investigations . One of the long - standing issues surrounding cholesterol relates to its two - fac...
Malignant tumors metastatic to the oral cavity are uncommon, comprising about 1% of newly diagnosed oral malignancies . The mandible is affected more frequently than the maxilla, with a predilection for the areas distal to the canines, including the body and ramus . Cancers from almost any primary site can metastasize ...
Palmaris longus (pl) is a thin, tendinous superficial flexor of forearm, functionally more active in non - human primates . In humans, pl is a weak flexor of the hand at wrist, tenses the palmar aponeurosis and is one of the most variable muscles in the body . The variation includes unilateral or bilateral agenesis, du...
Breast cancer rates are increasing in developing countries, including egypt, and are largely attributed to aging of the population, delay in time of first pregnancy, decrease in number of children and in breastfeeding, and a move toward high - calorie western diets [14]. Although breast cancer incidence rates in egypt ...
A 65-year - old male who was a chronic smoker for the last 30 years presented with generalized weakness, breathlessness, occasional hemoptysis, and multiple cutaneous nodules (8 in number) all over the body since two months . The nodules were present over the chest (2), abdomen (1), back (2), face (1), and both the ext...
A 70-years - old woman visited the department with a complaint of discomfort on the left preauricular area during mastication and mouth opening, which had occurred 3 or 4 months before . On the clinical examination additionally, a well - formed, impacted tooth was found in the right condylar head of the mandible . 1). ...
In contrast to crohn s disease, the immunopathogenesis of ulcerative colitis (uc) has been a more difficult disease to ascertain . This owing to the fact that it did not fit neatly into a niche of the th1/th2 paradigm . In particular, it was evident that cells from this disease produced neither excessive ifn- (th1), no...
The incidence and prevalence rates for these tumors are double in men than in women . Cancers of the oral cavity rank as the eighth most common cancer among men, being responsible for 3% of the cancers diagnosed in this gender . Mortality rates are substantially lower than incidence rates . According to the world healt...
Skeletal muscle atrophy results from a variety of conditions such as hindlimb unloading [1, 2], joint immobilization [3, 4], denervation [5, 6], and spinal cord injury [79]. Generally resistance exercise training is performed as an effective therapeutic intervention to prevent muscle atrophy induced by these diverse co...
In addition, the costs associated with the long - term care of these chronic wounds are substantial . Conventional therapies such as dressings, surgical debridement, compression bandage and even skin grafting cannot provide satisfactory healing since these treatments are not able to provide necessary growth factors tha...