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The use of metals in orthopedics is widespread, and there has been increasing concern with regards to the possibility of developing cutaneous and systemic hypersensitivity reactions to constituent metals in implant devices . Although hypersensitivity reactions to metals are not common, they require evaluation and manag...
The ichd - ii divides headache attributed to infection into four categories: (1) headache attributed to intracranial infection, (2) headache attributed to systemic infection, (3) headache attributed to hiv / aids, and (4) chronic post - infection headache . A diagnosis of headache attributed to an infection usually bec...
There is a scanty literature support describing the incidence, mechanism of lateral dislocations of thoracolumbar spine and its management describing the reduction techniques . Hereby we present an interesting case of extruded disc acting as buttonhole preventing the reduction of lateral dislocation of l1-l2 vertebrae ...
Am fungi and their cmns play a significant role in plant ecosystems and control the fitness and competitiveness of the plant individuals within their cmns . Our current understanding about resource exchange in the am symbiosis is primarily based on experiments with root organ cultures or with single plants that are col...
All of the archival hematoxylin and eosin (h&e) stained slides for each patient were reviewed . The nuclear grades and histologic grades were evaluated according to the nottingham grading system.9 the tumor stages were evaluated according to the 7th edition of the american joint committee on cancer (ajcc) criteria . Th...
The vascular endothelium provides a cellular interface between the circulating blood and the vascular smooth muscle of the blood vessel walls . It also has an important role in maintaining the balance of the endovascular environment . Many factors, such as peroxide, ox - low density lipoprotein (ldl), angiotensin i, an...
It mostly develops in early childhood and is characterized by recurrent episodes of wheezing, breathlessness, and coughing due to airway inflammation and airway hyperresponsiveness . However, in the majority of children symptoms are virally induced and transient (so - called transient wheezers). So, the associated airw...
In contrast to genome sequences, which are quickly becoming a commodity, the functional connectivity within a proteome is a much more challenging problem . The various protein complexes, transient interactions and functional pathways are all context - dependent, and the experimental techniques for their elucidation are...
The study was approved by the local ethics committee and written informed consent was obtained from all study participants . All procedures involving animals were authorized by the local institutional ethical animal committee and by the italian general direction for animal health at the ministry for health . Blood was ...
The treatment of primary and metastatic human brain tumors (hbts) faces important challenges due to the presence of the blood brain barrier that limits the diffusion of anticancer drugs . For instance, while the serum concentrations of etoposide after a dose of 50 mg / m can reach values> 1 mg / l (~1.7 m), the average...
The aim of this report is to present a previously unreported causative organism associated with brown - pigmented hypopyon in a patient with endophthalmitis . Vitreous cultures demonstrated streptococcus bovis infection resulting in a brown - pigmented hypopyon, with uveal pigment found intra- and extracellularly on pa...
Oocyte growth is accompanied by follicular growth . Once the primordial follicle is activated, a few flattened granulosa cells become cuboidal and increase in number, while the oocytes increase in size . Follicles are classified based on morphology and size: primary follicles are surrounded by a single layer of columna...
Hepatitis c virus (hcv) is the most common blood - borne infection and a major cause of chronic liver disease, cirrhosis, and primary hepatocellular carcinoma and one of the leading indications for liver transplant . The current standard therapy for chronic hcv (pegylated - interferon- (pegifn-) combined with ribavirin...
Multiple chemical sensitivity (mcs), also known as chemical intolerance (ci) or chemical hypersensitivity, is an emerging disabling illness characterized by chronic adverse effects from exposure to low levels of chemicals in the modern human environment . Symptoms can range from mild to disabling and commonly include f...
A brain computer interface (bci) provides an alternative communication channel for healthy or disabled users from their brains to external environment . A bci system can detect changes of the state of mind from the on - going eeg and control an external device (e.g., text - entry system, prosthesis, and computer game)....
Zotepine is being marketed in india since september 2010 for the treatment of schizophrenia . By presenting this report, our aim is to share our clinical experience regarding the tolerability and the side effects of zotepine treatment in schizophrenia patients . To our knowledge, there has been no study conducted to as...
All animal care and experiments conformed to the guidelines for animal experiments of ahe university of tokyo and were approved by the animal research committee of the university of tokyo . The left and right zfn plasmids were constructed by the overlap extension pcr and ta cloning (olta) method according to a previous...
The keystone to improving disease management and health outcomes remains the early and accurate diagnosis of the predisposition to, or onset of, disease . Early detection of disease risk and onset is the first step in implementing efficacious treatment and improving patient outcomes . In the context of screening for pr...
The pectoralis major muscle in humans is a large fan shaped muscle situated at the anterior upper part of the chest . It is complex in that it has two separate muscular bellies and a dual nerve supply . The clavicular portion of the pectoralis major muscle arises from the medial one half to two thirds of the clavicle, ...
Most obstetrical inpatient stays are short often no more than one or two days and the involvement of the inpatient consultation - liaison (c - l) psychiatry service, when required, is necessarily brief . Regardless of its compendious quality, however, its impact can have significance for the patient . We have previousl...
Functional gastrointestinal disorders (fgids) are chronic conditions that are considered to have no structural or biochemical abnormalities that account for the symptoms.1 fgids are not life threatening conditions, however, they significantly could impair the quality of life (qol). Fgids are important to public health ...
The pandemic of obesity is one of the greatest public health risks in industrialized countries . In australia, for instance, the prevalence of obesity (body mass index> 30) has more than doubled in the past 25 years . Bariatric surgery is now proven to be the most effective means of achieving sustainable weight loss fr...
Cancer is a complicated disease that develops slowly due to gradual accumulation of genetic and epigenetic alterations over time [1, 2]. Tumor cells often harbor mutations followed by activated oncogene expression and inactivated tumor - suppressor expression . These alterations combined with dysregulation of cell divi...
Cochlear implantation outcomes are dependent on several factors that lead to a good prognosis, such as early diagnosis and intervention, systematic rehabilitation, family permeability, and type of communication, as well as other factors related to hearing loss including etiology, period of deafness, and the presence of...
In the current guidelines for treatment of pulmonary arterial hypertension (pah), therapeutic options for hiv - related pulmonary hypertension (hrph) are less well established as compared to other forms of pah, and there are still controversial data on the role of the antiretroviral therapy (art) in the management of p...
In the previous issue of critical care, osuka and colleagues from the osaka university hospital and school of medicine examine fecal ph as a proxy for composition and functional alterations in the gut flora that predict outcome in critically ill patients . This work builds on and extends their previous work examining t...
Myopic eyes are often accompanied by tilted optic discs, which are associated with a series of findings, including a vertically oval optic disc,13 nasally undermined cupping, 1,4 nasally displaced vessels in the cupping,1,3,4 and the presence of a temporal crescent.13,5 in our clinical practice in japan, we observed th...
Ceftriaxone is a widely used third - generation semi synthetic cephalosporin commonly administrated for treatment of different bacterial infections in children . Due to its broad spectrum against bacteria, long half - life and single daily dosing, physicians prefer to use it more frequently . Ceftriaxone is mostly elim...
Volatile agents have cardioprotective properties that might result in a reduction of postoperative mortality in cardiac surgery . Successful inhalation induction for adults in non - cardiac surgery is well established and requires poorly soluble, reasonably potent and minimally irritant agent . Because sevoflurane has ...
The successes of these procedures depend on the effective removal of infected dentin, prior to the placement of the restorative material . Any leftover bacterial remnants during and after the cavity preparation pose one of the major problem in restorative dentistry . Failure to mechanically remove the infected tooth st...
Rnai - based library screening has become a powerful in vitro tool to identify drug targets that play a role in disease development and progression (martin and caplen, 2007). Successful screening experiments using sirna require efficient delivery of highly functional and specific sirna molecules into appropriate cells ...
A 54-year - old african - american male with an unremarkable past medical and family history presented with a gradually worsening and painful swelling of his right middle finger, which severely impaired the use of his hand over several months . On physical examination, a mass was palpated on the proximal phalanx withou...
Most people employed in economic activities complain neck, shoulders, and lower back disease . In particular, when one uses a computer in an inappropriate posture for a long time, the centerline of the head moves forward and upward, which causes an increase in the weight of the head supported by the neck, ultimately re...
Head and neck cancer is the sixth most common human cancer, representing 3% of all types of cancer . They are located in the oral cavity in 48% of cases, and 90% of these are oral squamous cell carcinoma . More than 300,000 new cases worldwide are being diagnosed with oral squamous cell carcinoma annually . Approximate...
A novel class a serine carbapenemase detected in north carolina in 1996 was given the designation kpc-1 because it was first identified in klebsiella pneumoniae . Since then, a number of variants of this enzyme (currently up to kpc-8) have been identified and have spread globally . The mobile nature of the genetic elem...
Nowadays, there are many patients who want to restore their teeth more esthetically not only for the origin such as dental caries or tooth fracture but also for diastema . As the interests of patients in esthetics increased, a number of reports over the porcelain laminate veneer increased.1,2 interdental spacing in the...
Asterospicularia laurae utinomi is a moderately abundant soft coral species found in well lit areas of the great barrier reef, especially on reef flats . Fabricius and alderslade have remarked upon the similarity between the polyp structure of asterospicularia and those of the genera xenia and sympodium . The chemistry...
One of the most popular approaches for identifying loci recently impacted by positive selection is known as hitchhiking mapping this approach involves scanning across a large number of regions in order to determine the average levels of variability that are characteristic of the genomic environment . Regions that show ...
As ppos become the dominant model of managed health care in the private sector, policymakers have increasingly viewed ppos as an attractive option for medicare . As part of a larger effort to modernize medicare by adopting strategies widely used in the private sector, the 2003 medicare prescription drug, improvement, a...
Stricture dilatation is the primary method of management, but patients with strictures not amenable or responsive to dilatation require esophageal replacement . Failure of esophageal dilatation may be related to the severity of luminal narrowing or stricture length . Esophageal replacement with reinstitution of oral fe...
Tissue microarrays (tmas) are the perfect tools in pathology and beyond to analyze the abundance and spatial distribution of proteins in well - defined tissue sections by immunohistochemical means.14 the tma block can include up to many hundred or even more patient samples originating from a certain physiological state...
Adnexal masses can be benign or malignant and the benign masses greatly outnumber malignant ones.1 ovarian cancer is one of the most common gynecological malignancies and cause of death in the western world and the usa . It is also one of the most prevalent cancers in pakistan.2,3 precise characterization of an adnexal...
Fever is the most frequent presenting symptom in many ambulatory health care settings.1 the evaluation of a child with a fever is one of the primary - care physician's most perplexing clinical situations . Fever may herald the onset of a serious and life - threatening disease such as meningitis, or it may be the sole m...
Since the advent of highly active antiretroviral therapy (now referred to as combination antiretroviral therapy [cart]), high levels of adherence are requisite to achieve maximal viral control and to improve immunologic status, which results in fewer acquired immunodeficiency syndrome defining events and lower mortalit...
The tumor suppressor protein p53 is a transcription factor that, among other functions, up - regulates the expression of genes involved in cell - cycle arrest, senescence, and apoptosis in response to cellular stress . Its activity is modulated through key interactions with coactivators that control its stability and t...
Malaria, a vector borne infectious disease caused by the protozoan parasites (plasmodium) and transmitted to humans by the female anopheles mosquito, has remained a real and longstanding cause for concern, mainly in the tropical world . Malaria has now extended to areas that cover more than 40% of the world's populatio...
The study was performed in accordance with a protocol approved by the institutional review board of the noguchi memorial institute for medical research, and the institutional review board and institutional animal care and use committee of the us naval medical research unit no . 3 . Seven sites were selected from areas ...
The integrity of the genome is crucial for the correct functioning of the individual organism . Any perturbation that results in a loss of genomic integrity is likely to result in disregulation and consequent uncontrolled cellular proliferation . Maintenance of genomic integrity is orchestrated by a number of different...
Patients undergoing gynaecological surgery utilising transverse lower abdominal incisions experience severe pain during the first 48 h postoperatively, thus requiring a well - planned analgesia regimen in the post - operative period . Total abdominal hysterectomy (tah) is a commonly performed major surgical procedure w...
Olfactory disturbances significantly impair the patient's quality of life1 2 3 4 . The perception of smell occurs when odorant particles are inhaled and bind to olfactory receptors located in the olfactory neuroepithelium (on)5 . The nerve endings in this tissue have a unique capacity to regenerate5 6, which makes on a...
The enlargement usually leads to lower urinary tract symptoms,1 irrespective of whether it is benign or malignant . With wide acceptance of serum prostate - specific antigen (psa) estimation,2 the ability to differentiate malignant from benign prostatic enlargement with or without symptoms before instituting definitive...
Obesity is a major worldwide problem, over 30% of adults in western populations are obese, and there is growing evidence of the associated health risks associated [15]. The link between obesity and cancer risk has been studied extensively, but the results of individual studies do not suggest a consistent association [1...
Ghrelin is a peptide hormone that is secreted from stomach and circulates in the blood to activate the release of growth hormone from pituitary and stimulate appetite by acting on hypothalamic arcuate nucleus [1, 2]. Ghrelin is distributed in several tissues, such as gastrointestinal organs, pancreas, and brain, and st...
In the united states, 26 million people suffer from diabetes with 1.3 million more being diagnosed with the disease each year.1,2 an aging population, rising obesity rates, and an increasingly sedentary lifestyle have been attributed to the increase in the incidence and prevalence rates . Ten percent of adults and more...
Individuals with diabetes do not realize the consequences of poorly controlled blood sugars until injury occur [14]. The diabetes control and complications trial (dcct) showed that glycemic control delays the onset of microvascular and macrovascular complications . Glucose monitoring allows individuals with diabetes th...
The short qt syndrome (sqts) is linked to abbreviated qt intervals on the electrocardiogram and to an increased incidence of cardiac arrhythmias and of sudden death . The sqt3 variant was identified in an asymptomatic child with an abnormal electrocardiogram and in her father who had a history of presyncopal events and...
Acinetobacter baumannii is a non fermentative gram - negative coccobacillus that is emerged as opportunistic nosocomial pathogen . A variety of human infections caused by acinetobacter species have been reviewed including pneumonia (most often related to endotracheal tubes or tracheostomies), endocarditis, meningitis, ...
Thrombotic thrombocytopenic purpura (ttp) is associated with a decrease in the activity of the von willebrand factor - cleaving protease adamts13 . This decrease can be due to a congenital deficiency or the presence of an inhibitor . The treatment of ttp in the presence of an inhibitor is plasmapheresis to remove the i...
Perioperative myocardial ischaemia (pmi) is a serious complication of cardiac surgery, which considerably increases the risk of mortality and morbidity . Patients with a history of pmi are at a higher risk of experiencing early complications than others . The probability of remaining free of newer cardiac events in tho...
Sea buckthorn (hippophae rhamnoides l., elaeagnaceae) constitutes a thorny nitrogen fixing deciduous shrub which cultivated various parts of the world for its nutritional and medicinal values . A sea buckthorn fruits (figure 1), seed (figure 2) and other parts is primarily valued for its very rich vitamins a, b1, b12, ...
Empowerment appears to mainly affect the use of prenatal care services and with the promotion of empowerment during pregnancy, we can improve mothers reproductive health (1). It is necessary for all women to make proactive decisions about their health and pregnancy in order to demonstrate their many capabilities and co...
Type 2 diabetes mellitus is one of the most common and disabling metabolic diseases; its increasing incidence has become a serious threat to human health . Increasing evidence suggests that hyperuricemia is an independent risk factor for impaired fasting glucose (ifg) and type 2 diabetes . Patients with hyperuricemia a...
It helps by killing microorganisms, flushing debris, and removing the smear layer from the root canal system . Smear layer prevents the penetration of intracanal medicaments into dentinal tubules and influences the adaptation of filling materials to canal walls . It consists of organic and inorganic substances, includi...
Selective laser trabeculoplasty (slt) was considered as an effective and safe surgery for lowering intraocular pressure (iop) [13] since it has initially been described in 1995 . Slt, a 532 nm frequency - doubled and q - switched neodymium (nd): yttrium - aluminum - garnet (yag) laser, is capable of targeting pigmented...
Granular cell tumor also known as abrikossoff's tumor or granular cell myoblastoma was variably considered as being a true neoplasm, degenerative metabolic process or trauma - induced lesion . A 9-year - old female patient presented to the dental clinic with a chief complaint of a swelling on the left side of her tongu...
Advances in minimally invasive surgery have led to the development of many novel surgical techniques . Single - incision laparoscopic surgery (sils) and natural orifice transluminal endoscopic surgery (notes) are among the techniques that are designed to further reduce surgical trauma and enhance postoperative recovery...
The aim of every dentist is to fabricate restorations in harmony with the patient's functional movements, to avoid interferences and subsequent disharmony in the stomatognathic system . Dental articulators accurately simulate patient's mandibular movements and aid in restoring occlusion . Programming semi - adjustable ...
Magnesium (mg) is the fourth most abundant cation in the human body and is a critical cofactor in many enzymatic reactions [1, 2]. An australian study demonstrated that hypomagnesaemia was 10.51-fold more common between patients with new diabetes and 8.63-fold more common between patients with known diabetes as compare...
The local inflammatory response to pathogenic bacteria or bacterial products is characterized by infiltration of the periodontal tissues of inflammatory cells including polymorphonuclear neutrophils, macrophages, lymphocytes, and plasma cells . The acute - phase response is a nonspecific process, initiated and coordina...
The sternocleidomastoid (scm) is a long neck muscle with two bellies, a medially located sternomastoid (sm) and laterally positioned cleidomastoid (cm). The sm is involved in the control of head movements and causes cranial displacement of the sternum and ribcage during conscious respiratory efforts [26]. It has been w...
Excess body weight, from overweight to overt obesity, is associated with adverse health outcomes . In view of the time - trends of the obesity epidemic and the related cost burden, the search for effective strategies for weight reduction and long - term maintenance of weight loss (wl) is at the top of the agenda of pub...
Elderly people experience rapid physical aging and deterioration of physical function as they get older1 . Depression in senescence, in particular, is known to not only decrease life satisfaction, but to also increase the potential mortality rate due to increased occurrence rate of physical disease and greater risk of ...
Non melanoma skin cancer is 1820 times more frequent than cutaneous malignant melanoma (mm). Although mortality from basal cell carcinoma (bcc) and squamous cell carcinoma (scc) is low but there may be a substantial morbidity from disfigurement as the lesions tend to be located on the skin of the head and neck . Accord...
The semibead - like single - crystalline pt electrodes were purchased from icryst . The electrolyte solutions of hclo4 and h2so4 were prepared by hclo4 (70%, suprapur, merck) and h2so4 (96%, suprapur, merck). The ultrapure water (resistivity> 18.2 mcm) was produced by a milli - q gradient a10 system . The gases of h2, ...
Hemangiopericytoma is a rare tumor, first described in 1942, mostly composed of pericytes of ramified appearance that are normally found all along the venules and capillaries . The adult form is most common in the lower extremities, but also occurs in the pelvis or retroperitoneum or other sites . The development of he...
We measured drug inhibition of hiv-1 infection using a single round infectivity assay as previously described . We chose a single round assay because complex factors such as growth and death of target cells distort m in multiround assays . To accurately mimic infection events in vivo, we carried out infections in prima...
Verrucous hemangioma is a rare variety of angiomatous nevi usually involving the, lower extremities . It has been reported under a diversity of names such as angiokeratoma circum - scriptum neviforme, unilateral verrucous heman - gioma, keratotic hemangioma etc . They are best treated by excision while still small, as ...
Most women in menopause report at least one symptom, such as hot flashes, night sweats, or sleep disturbances.1 the prevalence of these symptoms varies widely and is likely to be influenced by a range of factors, including climate, diet, lifestyle, women s roles and attitudes regarding aging, and the end of reproductiv...
This study was conducted at a large midwestern academic institution . The pediatric residency program at our institution trains over 40 residents per year, with modules in general pediatrics and combined medicine - pediatric pathways . The hospital also supports one of the largest nicus in the country, with 168 neonata...
For decades, scientists have collated data from the collection of semen samples from the world over to establish norms for use by the wider scientific community . Some standardization in the collection process has been guided by the world health organization s various published guidelines for semen management and resul...
The prevalence of cardiovascular disease (cvd) in rural india is 7.4%, and in urban india, it is 11% . The incidence of ischaemic heart disease (ihd) and coronary heart disease (chd) is steadily increasing in the indian subcontinent . According to world health report 2002 this number will represent 54.1% of all cvd dea...
The placement of central venous catheter using seldinger's technique, though a commonly performed procedure in the intensive care unit, has its own risks and complications . Various complications have been reported with the use of guide wire as well as catheter . Both malposition and entrapment of guidewire are known t...
The food practices of humans are determined by values, attitudes, beliefs, and environmental and religious circumstances; all of which are the products of tradition, culture, and contacts (onuorah and ayo, 2003). Knowledge and culture affect the intake of a particular food (asp, 1999). The success in understanding the ...
Dereplication of an active etoac - soluble fraction obtained from liquid liquid partition of the extract (100 mg) as previously described indicated that it contained at least one new bioactive compound, so a larger sample was investigated . Fractionation of this extract yielded an antiproliferative etoac fraction, whic...
Shock is a condition in which tissue perfusion is inadequate to maintain the normal oxygen demand . Cardiovascular adaptation during blood loss is under the control of the sympathetic and parasympathetic divisions . Hypotension during hemorrhage is associated with complications such as multiple organ failure, including...
The major causes of morbidity and mortality in western societies have been associated with cardiac hypertrophy and heart failure, which are influenced by several factors [1, 2]. In this context, the cardiomyocytes are known to play important role in the adaptation of myocardial structure and function during cardiac hyp...
Glaucoma is a group of diseases characterized by chronic progressive optic neuropathy caused by degeneration of retinal ganglion cells and their axons, resulting in the typical appearance of the optic disc, which differentiates it from other optic neuropathies and their visual - field defects [14]. There is thinning of...
Mucoepidermoid carcinoma is the most common malignancy of the salivary gland, accounts for about 34% of the malignant epithelial tumor . More than eight potential variants of mucoepidermoid carcinoma have been introduced, which includes unicystic, sclerosing, oncocytic, clear cell, spindle cell, goblet cell aggressive,...
There are many studies confirming the presence of helicobacter pylori in the saliva, oral cavity, nose, and mucus of the sinuses,[46] middle ear, dental plaques, tonsils, and adenoid glands . H. pylori has the potential to induce systemic inflammatory reactions through the immunological processes leading to the develop...
Her blood counts were as follows: hemoglobin, 18.2 g / dl; hematocrit, 55.1%; platelets, 36110/l; and leukocytes, 6.8210/l . Serum chemistry values were as follows: creatinine, 0.9 mg / dl (normal range, 0.5 - 1.3); albumin, 5.4 g / dl (4.0 - 5.2); ldh, 359 iu / l (180 - 460); alp, 62 iu / l (104 - 338); calcium, 12.6 ...
Breast cancer is the second leading cause of death among women in the united states.1 the increasing use of mammography and increased awareness of breast cancer among women has resulted in early detection of localized breast cancer . This has led to marked improvement in the cure rate for the disease, which is rapidly ...
Most tumours are sporadic, but as many as one third occur in the course of the hereditary disorder - von hippel - lindau disease (vhl). Vhl disease is a rare autosomal dominant disorder characterized by a predisposition to hemangioblastomas of the central nervous system (chab) and retina, renal cell carcinomas and pheo...
The sedatives and analgesics used during anesthetic procedures are known to produce undesirable effects on cardiac hemodynamics . But there is no other diagnostic test to evaluate this emergency situation except a meticulous clinical observation of sustained hypotension with tissue hypoperfusion despite adequate left v...
Primary cardiac lymphoma (pcl) is a rare malignancy.1)2) furthermore, bi - atrial involvement is extremely rare, and most of the previous cases have been b - cell lymphomas.3) we report here a case of pcl with involvement of both atria and the atrial septum . A 63 year old female without any previous medical history pr...
A 34-year - old woman with obesity (height, 150 cm; weight, 65 kg; and body mass index, 28.8 kg / m) and a short neck (fig . 1) suddenly developed dyspnea, seizure, and drowsy change of mental status and was transferred to our hospital for management . Her diagnosis was spontaneous subarachnoid hemorrhage due to left m...
Cleidocranial dysplasia (ccd) is a rare developmental disease with skeletal dysplasia and is considered to be of autosomal dominant inheritance (1). Individuals with ccd are typically of short stature, with brachycephalic skull and bossing of the parietal and frontal bones (2). Hypoplasia of the mid - face in patients ...
Recent developments in optical coherence tomography (oct) technology have now enabled clinicians to visualize vascular flow within the retina and choroid and around the optic disc [1, 2]. Optical coherence tomography angiography (octa) detects blood flow by analyzing signal decorrelation or phase deviations between ult...
Gestational diabetes mellitus (gdm) occurs in 25% of all pregnancies and is known to be associated with poor maternal and fetal outcomes . Apart from being implicated as a risk factor for future type 2 diabetes in the mother, gdm also leads to several adverse fetal outcomes such as macrosomia, shoulder dystocia and oth...
The occurrence and progression of nervous system injury and related diseases is a process involving changes in synapse number, structure and function . Therefore, the effective regulation of synapse formation and function is important for the treatment of nervous system diseases . Recent evidence indicates that astrocy...